ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.63192894
2	response to pheromone (GO:0019236)	4.56896345
3	L-fucose catabolic process (GO:0042355)	4.15074811
4	fucose catabolic process (GO:0019317)	4.15074811
5	L-fucose metabolic process (GO:0042354)	4.15074811
6	DNA deamination (GO:0045006)	3.96967713
7	negative regulation of telomere maintenance (GO:0032205)	3.63741372
8	axoneme assembly (GO:0035082)	3.50884504
9	epithelial cilium movement (GO:0003351)	3.46602386
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.43302330
11	preassembly of GPI anchor in ER membrane (GO:0016254)	3.39995843
12	nonmotile primary cilium assembly (GO:0035058)	3.31219201
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.28917025
14	NADH dehydrogenase complex assembly (GO:0010257)	3.28917025
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.28917025
16	hindbrain development (GO:0030902)	3.27776308
17	cellular ketone body metabolic process (GO:0046950)	3.18577534
18	protein complex biogenesis (GO:0070271)	3.16169018
19	piRNA metabolic process (GO:0034587)	3.10845877
20	protein-cofactor linkage (GO:0018065)	3.10676474
21	somite development (GO:0061053)	3.05722776
22	protein localization to cilium (GO:0061512)	3.04397509
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.03718819
24	detection of light stimulus involved in sensory perception (GO:0050962)	3.02163292
25	detection of light stimulus involved in visual perception (GO:0050908)	3.02163292
26	pyrimidine nucleobase catabolic process (GO:0006208)	3.00548133
27	platelet dense granule organization (GO:0060155)	2.96282883
28	retinal cone cell development (GO:0046549)	2.94884651
29	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.93941995
30	ATP synthesis coupled proton transport (GO:0015986)	2.93614832
31	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.93614832
32	indolalkylamine metabolic process (GO:0006586)	2.90861616
33	kynurenine metabolic process (GO:0070189)	2.89843219
34	neural tube formation (GO:0001841)	2.88943980
35	water-soluble vitamin biosynthetic process (GO:0042364)	2.88634710
36	axonemal dynein complex assembly (GO:0070286)	2.87564407
37	protein K6-linked ubiquitination (GO:0085020)	2.86485731
38	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.86426103
39	regulation of cilium movement (GO:0003352)	2.86241725
40	mitochondrial respiratory chain complex assembly (GO:0033108)	2.84763984
41	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.84548109
42	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.84212505
43	mannosylation (GO:0097502)	2.83771115
44	adaptation of signaling pathway (GO:0023058)	2.82416177
45	ketone body metabolic process (GO:1902224)	2.81583428
46	cornea development in camera-type eye (GO:0061303)	2.81013750
47	cilium movement (GO:0003341)	2.80565422
48	replication fork processing (GO:0031297)	2.80134914
49	protein polyglutamylation (GO:0018095)	2.74770805
50	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.71904611
51	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.71339931
52	reciprocal DNA recombination (GO:0035825)	2.70014977
53	reciprocal meiotic recombination (GO:0007131)	2.70014977
54	GPI anchor metabolic process (GO:0006505)	2.69841695
55	tryptophan catabolic process (GO:0006569)	2.69467131
56	indole-containing compound catabolic process (GO:0042436)	2.69467131
57	indolalkylamine catabolic process (GO:0046218)	2.69467131
58	behavioral response to ethanol (GO:0048149)	2.68505991
59	endoderm formation (GO:0001706)	2.67197636
60	neuronal action potential (GO:0019228)	2.67064119
61	head development (GO:0060322)	2.66404815
62	gamma-aminobutyric acid transport (GO:0015812)	2.66224186
63	DNA methylation involved in gamete generation (GO:0043046)	2.63080868
64	positive regulation of meiosis (GO:0045836)	2.61838242
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.61303188
66	cilium morphogenesis (GO:0060271)	2.61258918
67	inner ear receptor stereocilium organization (GO:0060122)	2.60021616
68	regulation of telomere maintenance (GO:0032204)	2.59920366
69	auditory receptor cell stereocilium organization (GO:0060088)	2.59879085
70	cilium organization (GO:0044782)	2.56228664
71	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.55612051
72	centriole replication (GO:0007099)	2.55096291
73	kidney morphogenesis (GO:0060993)	2.52901752
74	regulation of mesoderm development (GO:2000380)	2.52729111
75	rRNA catabolic process (GO:0016075)	2.52248531
76	nucleobase catabolic process (GO:0046113)	2.51508296
77	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.50954579
78	photoreceptor cell development (GO:0042461)	2.50548355
79	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.49844892
80	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.49844892
81	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.49590845
82	respiratory chain complex IV assembly (GO:0008535)	2.49463731
83	cilium assembly (GO:0042384)	2.47737797
84	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.47525583
85	regulation of mitotic spindle checkpoint (GO:1903504)	2.47525583
86	regulation of action potential (GO:0098900)	2.45194375
87	tryptophan metabolic process (GO:0006568)	2.44847112
88	S-adenosylmethionine metabolic process (GO:0046500)	2.44418393
89	regulation of meiosis I (GO:0060631)	2.43433594
90	photoreceptor cell maintenance (GO:0045494)	2.43255294
91	positive regulation of meiotic cell cycle (GO:0051446)	2.42035005
92	startle response (GO:0001964)	2.41926358
93	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.41444621
94	recombinational repair (GO:0000725)	2.39954641
95	synaptic transmission, cholinergic (GO:0007271)	2.39146391
96	double-strand break repair via homologous recombination (GO:0000724)	2.37204653
97	male meiosis I (GO:0007141)	2.36326296
98	pseudouridine synthesis (GO:0001522)	2.36300235
99	reflex (GO:0060004)	2.35821571
100	regulation of collateral sprouting (GO:0048670)	2.35527428

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.04996422
2	VDR_22108803_ChIP-Seq_LS180_Human	3.69772636
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.86026417
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.60192587
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.57601071
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.49913350
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.38733297
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.32108849
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.31420247
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.25045705
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.24312153
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.22194012
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.19408100
14	EWS_26573619_Chip-Seq_HEK293_Human	2.18953338
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.18445813
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10545085
17	P300_19829295_ChIP-Seq_ESCs_Human	2.04144313
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.03873711
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.01423065
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.93156303
21	FUS_26573619_Chip-Seq_HEK293_Human	1.92439228
22	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.90771053
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.89411310
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.84058194
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.82102703
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.78323874
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.73025248
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.68555346
29	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.67330029
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.67089745
31	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64521987
32	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.64484612
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.63797065
34	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.61650528
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.61650528
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.56363385
37	RNF2_27304074_Chip-Seq_NSC_Mouse	1.56033746
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.50456484
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49794976
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.49794976
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49474104
42	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43427808
43	STAT3_23295773_ChIP-Seq_U87_Human	1.43044898
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.41513083
45	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.41074069
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39015914
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.38555028
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37046907
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37046907
50	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.36455104
51	SMAD4_21799915_ChIP-Seq_A2780_Human	1.35761749
52	AR_25329375_ChIP-Seq_VCAP_Human	1.35688962
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.35665950
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35539778
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35539778
56	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.34583686
57	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.32330878
58	ELK1_19687146_ChIP-ChIP_HELA_Human	1.31383994
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31102485
60	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.30444168
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30245822
62	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.29978330
63	VDR_23849224_ChIP-Seq_CD4+_Human	1.28949320
64	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28156048
65	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26581040
66	TCF4_23295773_ChIP-Seq_U87_Human	1.25998625
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25170524
68	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.24388333
69	NCOR_22424771_ChIP-Seq_293T_Human	1.22242089
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22091580
71	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.20908285
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.19994218
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19674710
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18614856
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18533356
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16654418
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16093393
78	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15670168
79	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.14547432
80	AR_21572438_ChIP-Seq_LNCaP_Human	1.11853871
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10826151
82	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09477337
83	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.09248360
84	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08842104
85	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.08483563
86	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.08189536
87	AR_20517297_ChIP-Seq_VCAP_Human	1.07084529
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05272367
89	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.04761402
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04481500
91	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04194179
92	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03886271
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03875535
94	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.01667411
95	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.01210961
96	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01152093
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00868250
98	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.95943403
99	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95782028
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95773085

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.66145730
2	MP0003787_abnormal_imprinting	2.75835863
3	MP0000569_abnormal_digit_pigmentation	2.51117718
4	MP0004885_abnormal_endolymph	2.45497941
5	MP0001968_abnormal_touch/_nociception	2.38164796
6	MP0002102_abnormal_ear_morphology	2.32864976
7	MP0002638_abnormal_pupillary_reflex	2.28907035
8	MP0005551_abnormal_eye_electrophysiolog	2.16786995
9	MP0003195_calcinosis	2.16560058
10	MP0004142_abnormal_muscle_tone	2.11185561
11	MP0006292_abnormal_olfactory_placode	1.99634567
12	MP0004133_heterotaxia	1.99490652
13	MP0006072_abnormal_retinal_apoptosis	1.98495305
14	MP0003880_abnormal_central_pattern	1.93776705
15	MP0002736_abnormal_nociception_after	1.86151341
16	MP0005645_abnormal_hypothalamus_physiol	1.83460692
17	MP0003122_maternal_imprinting	1.80634639
18	MP0004742_abnormal_vestibular_system	1.78781734
19	MP0005084_abnormal_gallbladder_morpholo	1.78225106
20	MP0001986_abnormal_taste_sensitivity	1.78078908
21	MP0002876_abnormal_thyroid_physiology	1.77538248
22	MP0006276_abnormal_autonomic_nervous	1.71305615
23	MP0002653_abnormal_ependyma_morphology	1.70192497
24	MP0004147_increased_porphyrin_level	1.68647325
25	MP0002837_dystrophic_cardiac_calcinosis	1.68087258
26	MP0009745_abnormal_behavioral_response	1.68081376
27	MP0005646_abnormal_pituitary_gland	1.64743776
28	MP0002928_abnormal_bile_duct	1.64094222
29	MP0003121_genomic_imprinting	1.61201771
30	MP0002272_abnormal_nervous_system	1.60545114
31	MP0000427_abnormal_hair_cycle	1.59753514
32	MP0002138_abnormal_hepatobiliary_system	1.58129754
33	MP0002938_white_spotting	1.54675696
34	MP0009046_muscle_twitch	1.52884383
35	MP0008872_abnormal_physiological_respon	1.51005798
36	MP0000372_irregular_coat_pigmentation	1.49621205
37	MP0008875_abnormal_xenobiotic_pharmacok	1.48848918
38	MP0002163_abnormal_gland_morphology	1.48652962
39	MP0001529_abnormal_vocalization	1.47298128
40	MP0005253_abnormal_eye_physiology	1.43300404
41	MP0008058_abnormal_DNA_repair	1.41624266
42	MP0002735_abnormal_chemical_nociception	1.40112380
43	MP0003011_delayed_dark_adaptation	1.39907425
44	MP0002160_abnormal_reproductive_system	1.36947100
45	MP0002733_abnormal_thermal_nociception	1.36858163
46	MP0001486_abnormal_startle_reflex	1.34786940
47	MP0002572_abnormal_emotion/affect_behav	1.32454947
48	MP0000566_synostosis	1.32106521
49	MP0003890_abnormal_embryonic-extraembry	1.30367891
50	MP0001485_abnormal_pinna_reflex	1.29986115
51	MP0001984_abnormal_olfaction	1.29333910
52	MP0005389_reproductive_system_phenotype	1.29280050
53	MP0002067_abnormal_sensory_capabilities	1.28366504
54	MP0008789_abnormal_olfactory_epithelium	1.28359764
55	MP0001970_abnormal_pain_threshold	1.27894243
56	MP0008995_early_reproductive_senescence	1.26434629
57	MP0004145_abnormal_muscle_electrophysio	1.23591396
58	MP0002234_abnormal_pharynx_morphology	1.23205782
59	MP0003283_abnormal_digestive_organ	1.23119604
60	MP0005423_abnormal_somatic_nervous	1.22701563
61	MP0002557_abnormal_social/conspecific_i	1.21500564
62	MP0001919_abnormal_reproductive_system	1.17677893
63	MP0000631_abnormal_neuroendocrine_gland	1.17213370
64	MP0002064_seizures	1.13592356
65	MP0000778_abnormal_nervous_system	1.10513953
66	MP0003136_yellow_coat_color	1.10088992
67	MP0001440_abnormal_grooming_behavior	1.09590279
68	MP0005379_endocrine/exocrine_gland_phen	1.09549626
69	MP0002063_abnormal_learning/memory/cond	1.08486500
70	MP0002734_abnormal_mechanical_nocicepti	1.06808777
71	MP0000647_abnormal_sebaceous_gland	1.04876696
72	MP0001501_abnormal_sleep_pattern	1.03820121
73	MP0005499_abnormal_olfactory_system	1.02556255
74	MP0005394_taste/olfaction_phenotype	1.02556255
75	MP0001502_abnormal_circadian_rhythm	1.01748920
76	MP0003646_muscle_fatigue	1.01528858
77	MP0010386_abnormal_urinary_bladder	1.00752065
78	MP0002751_abnormal_autonomic_nervous	0.99729945
79	MP0005386_behavior/neurological_phenoty	0.99478133
80	MP0004924_abnormal_behavior	0.99478133
81	MP0003878_abnormal_ear_physiology	0.98590503
82	MP0005377_hearing/vestibular/ear_phenot	0.98590503
83	MP0005195_abnormal_posterior_eye	0.98330168
84	MP0003635_abnormal_synaptic_transmissio	0.93922827
85	MP0002752_abnormal_somatic_nervous	0.93278288
86	MP0000383_abnormal_hair_follicle	0.92556911
87	MP0003937_abnormal_limbs/digits/tail_de	0.89273221
88	MP0001905_abnormal_dopamine_level	0.87366547
89	MP0005671_abnormal_response_to	0.86252999
90	MP0003119_abnormal_digestive_system	0.86105588
91	MP0000026_abnormal_inner_ear	0.84798665
92	MP0002210_abnormal_sex_determination	0.84477199
93	MP0005187_abnormal_penis_morphology	0.83899123
94	MP0003698_abnormal_male_reproductive	0.83209752
95	MP0001929_abnormal_gametogenesis	0.82937968
96	MP0004043_abnormal_pH_regulation	0.82571059
97	MP0002095_abnormal_skin_pigmentation	0.81177065
98	MP0001324_abnormal_eye_pigmentation	0.80744976
99	MP0001293_anophthalmia	0.79129433
100	MP0002184_abnormal_innervation	0.78926968

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.35420452
2	Abnormality of midbrain morphology (HP:0002418)	3.95667064
3	Molar tooth sign on MRI (HP:0002419)	3.95667064
4	Pancreatic fibrosis (HP:0100732)	3.79534759
5	True hermaphroditism (HP:0010459)	3.68118050
6	Congenital stationary night blindness (HP:0007642)	3.66756489
7	Nephronophthisis (HP:0000090)	3.44289108
8	Medial flaring of the eyebrow (HP:0010747)	3.40583552
9	Type II lissencephaly (HP:0007260)	3.19939570
10	Abnormality of the renal cortex (HP:0011035)	3.17544684
11	Abnormality of the renal medulla (HP:0100957)	3.09664028
12	Gait imbalance (HP:0002141)	2.88569897
13	Abnormality of the labia minora (HP:0012880)	2.80674131
14	Congenital primary aphakia (HP:0007707)	2.70691242
15	Abolished electroretinogram (ERG) (HP:0000550)	2.62164130
16	Congenital, generalized hypertrichosis (HP:0004540)	2.57962137
17	Lissencephaly (HP:0001339)	2.53446038
18	Nephrogenic diabetes insipidus (HP:0009806)	2.51130589
19	Chronic hepatic failure (HP:0100626)	2.51112086
20	Stomach cancer (HP:0012126)	2.48328659
21	Polydipsia (HP:0001959)	2.47081407
22	Abnormal drinking behavior (HP:0030082)	2.47081407
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.46626823
24	Pendular nystagmus (HP:0012043)	2.44394492
25	Hypoplasia of the pons (HP:0012110)	2.42262082
26	Sclerocornea (HP:0000647)	2.38920763
27	Polyuria (HP:0000103)	2.38579623
28	Abnormality of the pons (HP:0007361)	2.37997803
29	Abnormal respiratory motile cilium morphology (HP:0005938)	2.37832259
30	Abnormal respiratory epithelium morphology (HP:0012253)	2.37832259
31	Cystic liver disease (HP:0006706)	2.36568295
32	Hypothermia (HP:0002045)	2.31972313
33	Acute necrotizing encephalopathy (HP:0006965)	2.29312393
34	Attenuation of retinal blood vessels (HP:0007843)	2.29225181
35	Inability to walk (HP:0002540)	2.28802468
36	Concave nail (HP:0001598)	2.26362468
37	Hyperventilation (HP:0002883)	2.24630238
38	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.21233321
39	Genital tract atresia (HP:0001827)	2.21155960
40	Absent/shortened dynein arms (HP:0200106)	2.20946615
41	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.20946615
42	Mitochondrial inheritance (HP:0001427)	2.19349727
43	Renal cortical cysts (HP:0000803)	2.18977086
44	Progressive inability to walk (HP:0002505)	2.18974602
45	Vaginal atresia (HP:0000148)	2.17797113
46	Increased CSF lactate (HP:0002490)	2.17460466
47	Tubular atrophy (HP:0000092)	2.16930625
48	Asplenia (HP:0001746)	2.13162401
49	Retinal dysplasia (HP:0007973)	2.11969584
50	Optic disc pallor (HP:0000543)	2.10557673
51	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.09100993
52	Hypomagnesemia (HP:0002917)	2.07975642
53	Anencephaly (HP:0002323)	2.06963065
54	Congenital hepatic fibrosis (HP:0002612)	2.05458939
55	Acute encephalopathy (HP:0006846)	2.05381519
56	Cerebellar dysplasia (HP:0007033)	2.05154632
57	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04211129
58	Abnormality of alanine metabolism (HP:0010916)	2.04211129
59	Hyperalaninemia (HP:0003348)	2.04211129
60	Progressive macrocephaly (HP:0004481)	2.03876183
61	Keratoconus (HP:0000563)	2.03182777
62	Increased corneal curvature (HP:0100692)	2.03182777
63	Abnormal respiratory motile cilium physiology (HP:0012261)	2.02212914
64	Occipital encephalocele (HP:0002085)	2.01474941
65	Lipid accumulation in hepatocytes (HP:0006561)	2.01119597
66	Poor coordination (HP:0002370)	2.00401065
67	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.98428414
68	Stomatitis (HP:0010280)	1.96166844
69	Limb dystonia (HP:0002451)	1.95017684
70	Abnormal mitochondria in muscle tissue (HP:0008316)	1.94709776
71	Abnormal ciliary motility (HP:0012262)	1.94231352
72	Patellar aplasia (HP:0006443)	1.92046310
73	3-Methylglutaconic aciduria (HP:0003535)	1.90044691
74	Increased hepatocellular lipid droplets (HP:0006565)	1.89822464
75	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.89162345
76	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.88790330
77	Abnormal number of erythroid precursors (HP:0012131)	1.88132322
78	Aplasia/Hypoplasia of the patella (HP:0006498)	1.87288034
79	Oligodactyly (hands) (HP:0001180)	1.84984943
80	Abnormal urine output (HP:0012590)	1.84714327
81	Bony spicule pigmentary retinopathy (HP:0007737)	1.82811995
82	Thyroid-stimulating hormone excess (HP:0002925)	1.82328236
83	Absent speech (HP:0001344)	1.82291945
84	Tachypnea (HP:0002789)	1.80976362
85	Specific learning disability (HP:0001328)	1.80747259
86	Pachygyria (HP:0001302)	1.80529858
87	Furrowed tongue (HP:0000221)	1.80042239
88	Decreased circulating renin level (HP:0003351)	1.79844948
89	Colon cancer (HP:0003003)	1.79678333
90	Chorioretinal atrophy (HP:0000533)	1.79049465
91	Aplasia/hypoplasia of the uterus (HP:0008684)	1.78886610
92	Postaxial foot polydactyly (HP:0001830)	1.77866490
93	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.77736158
94	Broad-based gait (HP:0002136)	1.73898711
95	Febrile seizures (HP:0002373)	1.73287619
96	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.72909308
97	Focal motor seizures (HP:0011153)	1.72134965
98	Postaxial hand polydactyly (HP:0001162)	1.70887266
99	Methylmalonic acidemia (HP:0002912)	1.70651011
100	Polyphagia (HP:0002591)	1.69960377

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.03553281
2	BMPR1B	3.55858839
3	ZAK	3.17513174
4	ADRBK2	3.10244871
5	WNK3	2.61145506
6	INSRR	2.44201668
7	CASK	2.41018673
8	NUAK1	2.38400722
9	TLK1	2.36735914
10	TXK	2.31229599
11	GRK1	2.21183319
12	WNK4	2.15718032
13	MAPK13	2.15614327
14	PINK1	2.12164192
15	MKNK2	1.80645918
16	TAOK3	1.79437820
17	TRIM28	1.77435521
18	MAP4K2	1.72884211
19	DYRK2	1.65092486
20	PNCK	1.60900174
21	MARK1	1.49893948
22	TGFBR1	1.38335439
23	OXSR1	1.37494347
24	TIE1	1.37309611
25	NTRK3	1.34010888
26	MAP3K4	1.33341258
27	CDK8	1.27817583
28	VRK1	1.20102092
29	PAK3	1.12194525
30	DYRK3	1.09248644
31	TSSK6	1.08223179
32	STK39	1.07189164
33	BCR	1.07136988
34	PRKCG	1.03777486
35	MST4	1.03276507
36	WEE1	1.01563133
37	DAPK2	0.99079934
38	MAPK15	0.98964755
39	SIK2	0.96854963
40	MKNK1	0.95636228
41	PIK3CA	0.94850128
42	PRKCE	0.94080107
43	TNIK	0.93944753
44	BCKDK	0.91449941
45	ADRBK1	0.91091629
46	PLK2	0.91049604
47	TEC	0.89135160
48	CAMKK2	0.83318368
49	PLK3	0.80169314
50	IKBKB	0.79595327
51	IRAK1	0.79356035
52	MAP2K7	0.78890161
53	PHKG1	0.75085732
54	PHKG2	0.75085732
55	BRSK2	0.75031452
56	PLK4	0.72893020
57	MAP2K2	0.72784089
58	ACVR1B	0.67666916
59	MAPKAPK5	0.65441497
60	CSNK1G2	0.64957460
61	FGFR2	0.62820161
62	MAPKAPK3	0.61932571
63	NME1	0.61122826
64	DYRK1A	0.58464584
65	ERBB3	0.57228275
66	CHUK	0.56987106
67	RPS6KA5	0.55965307
68	TAF1	0.53697805
69	NLK	0.53208010
70	PRKCQ	0.51668954
71	AKT3	0.51104605
72	CAMK2A	0.49370477
73	STK38L	0.49280348
74	ITK	0.49256681
75	CSNK1G1	0.48489675
76	STK11	0.48272763
77	CSNK1A1L	0.47329081
78	PRKACA	0.47185935
79	CSNK1G3	0.46682168
80	EPHA3	0.46607646
81	CSNK1A1	0.46346095
82	PRKCI	0.44466632
83	CHEK2	0.44347080
84	PASK	0.43831362
85	ATR	0.40895082
86	STK16	0.40751227
87	CDK19	0.38275244
88	PKN1	0.37493509
89	PRKG1	0.35027024
90	SYK	0.34910385
91	KIT	0.34632944
92	FLT3	0.34367413
93	CAMK1	0.33656066
94	NTRK2	0.33139180
95	PTK2B	0.32998762
96	CDC7	0.32970244
97	PRKCZ	0.31648885
98	SRPK1	0.31543749
99	PRKCA	0.30202908
100	ERBB2	0.30104072

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.85397510
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.75835942
3	Selenocompound metabolism_Homo sapiens_hsa00450	2.60176246
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.58677221
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.57688893
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.54956651
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.32079703
8	Nicotine addiction_Homo sapiens_hsa05033	2.28597060
9	Butanoate metabolism_Homo sapiens_hsa00650	2.26605308
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.19411378
11	Linoleic acid metabolism_Homo sapiens_hsa00591	2.17594906
12	Homologous recombination_Homo sapiens_hsa03440	2.17195661
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.16608831
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.15276820
15	Protein export_Homo sapiens_hsa03060	2.14639739
16	Parkinsons disease_Homo sapiens_hsa05012	2.02884095
17	RNA polymerase_Homo sapiens_hsa03020	1.92805835
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.90299302
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.85919714
20	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.82238159
21	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.81604767
22	Basal transcription factors_Homo sapiens_hsa03022	1.81294085
23	RNA degradation_Homo sapiens_hsa03018	1.62833160
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.51777441
25	Caffeine metabolism_Homo sapiens_hsa00232	1.49688456
26	Huntingtons disease_Homo sapiens_hsa05016	1.43945055
27	Alzheimers disease_Homo sapiens_hsa05010	1.37922066
28	Olfactory transduction_Homo sapiens_hsa04740	1.37783491
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.35778330
30	Morphine addiction_Homo sapiens_hsa05032	1.34213262
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.32807430
32	Taste transduction_Homo sapiens_hsa04742	1.29954092
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.24689977
34	Propanoate metabolism_Homo sapiens_hsa00640	1.24587497
35	Regulation of autophagy_Homo sapiens_hsa04140	1.21626205
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.18916049
37	Primary immunodeficiency_Homo sapiens_hsa05340	1.15586804
38	Peroxisome_Homo sapiens_hsa04146	1.14716195
39	One carbon pool by folate_Homo sapiens_hsa00670	1.13086737
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.09155289
41	ABC transporters_Homo sapiens_hsa02010	1.03215043
42	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.02709633
43	Proteasome_Homo sapiens_hsa03050	0.98287298
44	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.98211983
45	Non-homologous end-joining_Homo sapiens_hsa03450	0.95696397
46	GABAergic synapse_Homo sapiens_hsa04727	0.93002466
47	Ribosome_Homo sapiens_hsa03010	0.92554745
48	Insulin secretion_Homo sapiens_hsa04911	0.91068133
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.90051761
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.88449122
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87533719
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.87119768
53	Steroid biosynthesis_Homo sapiens_hsa00100	0.86713461
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84645162
55	Serotonergic synapse_Homo sapiens_hsa04726	0.84056436
56	Purine metabolism_Homo sapiens_hsa00230	0.83649827
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.82926487
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82441264
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82359090
60	Pyrimidine metabolism_Homo sapiens_hsa00240	0.77813973
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.77495086
62	Circadian entrainment_Homo sapiens_hsa04713	0.76484015
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.74471621
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.73193734
65	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.70689201
66	Circadian rhythm_Homo sapiens_hsa04710	0.68114554
67	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66893785
68	Retinol metabolism_Homo sapiens_hsa00830	0.66861210
69	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.61860855
70	Metabolic pathways_Homo sapiens_hsa01100	0.60292275
71	Nucleotide excision repair_Homo sapiens_hsa03420	0.58374022
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58214303
73	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.57688436
74	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.53369806
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.53147140
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51796558
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50351901
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48448412
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.47949047
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.46423725
81	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45968856
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.45631692
83	Amphetamine addiction_Homo sapiens_hsa05031	0.41014128
84	Fatty acid metabolism_Homo sapiens_hsa01212	0.39650619
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39615395
86	RNA transport_Homo sapiens_hsa03013	0.39488835
87	Sulfur metabolism_Homo sapiens_hsa00920	0.39240441
88	Calcium signaling pathway_Homo sapiens_hsa04020	0.38955075
89	Type I diabetes mellitus_Homo sapiens_hsa04940	0.38877201
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38559370
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38048491
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37953998
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.36895085
94	Cocaine addiction_Homo sapiens_hsa05030	0.36341566
95	Salivary secretion_Homo sapiens_hsa04970	0.36051581
96	Base excision repair_Homo sapiens_hsa03410	0.34463387
97	Mismatch repair_Homo sapiens_hsa03430	0.33960994
98	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.32684845
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.31472053
100	Asthma_Homo sapiens_hsa05310	0.31161106

ODCP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »