ODF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.92387642
2axonemal dynein complex assembly (GO:0070286)9.68114409
3motile cilium assembly (GO:0044458)9.29645107
4cilium or flagellum-dependent cell motility (GO:0001539)9.20369280
5reproduction (GO:0000003)9.13464668
6regulation of cilium movement (GO:0003352)8.96582619
7cilium movement (GO:0003341)8.22074941
8sperm capacitation (GO:0048240)7.73154001
9negative regulation of inclusion body assembly (GO:0090084)7.52987390
10protein targeting to Golgi (GO:0000042)7.40520758
11rRNA methylation (GO:0031167)7.38990051
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.32464406
13single fertilization (GO:0007338)7.29765023
14response to pheromone (GO:0019236)7.24192267
15establishment of protein localization to Golgi (GO:0072600)7.09267140
16organic cation transport (GO:0015695)7.05791568
17phosphatidylethanolamine biosynthetic process (GO:0006646)6.97638588
18retrograde transport, vesicle recycling within Golgi (GO:0000301)6.92711787
19synaptonemal complex organization (GO:0070193)6.83693599
20synaptonemal complex assembly (GO:0007130)6.68392652
21male meiosis (GO:0007140)6.68051079
22* spermatogenesis (GO:0007283)6.64286598
23* male gamete generation (GO:0048232)6.61874993
24microtubule depolymerization (GO:0007019)6.60457994
25piRNA metabolic process (GO:0034587)6.59559414
26phosphatidylethanolamine metabolic process (GO:0046337)6.43795388
27regulation of inclusion body assembly (GO:0090083)6.25622928
28rRNA modification (GO:0000154)6.22600937
29fertilization (GO:0009566)6.20689488
30* gamete generation (GO:0007276)6.07967602
31calcium ion-dependent exocytosis (GO:0017156)5.63231104
32centriole replication (GO:0007099)5.59954817
33germ cell development (GO:0007281)5.47520611
34regulation of microtubule-based movement (GO:0060632)5.45797779
35cellular process involved in reproduction in multicellular organism (GO:0022412)5.41431771
36cellular ketone body metabolic process (GO:0046950)5.39837133
37ventricular system development (GO:0021591)5.31935671
38protein localization to Golgi apparatus (GO:0034067)5.29552863
39chromosome condensation (GO:0030261)5.23353889
40centriole assembly (GO:0098534)5.05082698
41glycerol ether metabolic process (GO:0006662)5.02189174
42DNA packaging (GO:0006323)5.02170339
43cell recognition (GO:0008037)5.00891135
44spermatid nucleus differentiation (GO:0007289)4.87338210
45* multicellular organismal reproductive process (GO:0048609)4.82186579
46ketone body metabolic process (GO:1902224)4.76001345
47regulation of Rab GTPase activity (GO:0032313)4.73848849
48positive regulation of Rab GTPase activity (GO:0032851)4.73848849
49male meiosis I (GO:0007141)4.70450293
50ether metabolic process (GO:0018904)4.63897852
51microtubule severing (GO:0051013)4.62602440
52regulation of centriole replication (GO:0046599)4.61966787
53seminiferous tubule development (GO:0072520)4.55003523
54left/right pattern formation (GO:0060972)4.52238107
55chromosome organization involved in meiosis (GO:0070192)4.45822857
56sexual reproduction (GO:0019953)4.30353056
57regulation of transcription involved in cell fate commitment (GO:0060850)4.26619360
58chaperone-mediated protein complex assembly (GO:0051131)4.15426514
59DNA methylation involved in gamete generation (GO:0043046)4.12235389
60meiotic nuclear division (GO:0007126)3.99255892
61musculoskeletal movement (GO:0050881)3.92641862
62multicellular organismal movement (GO:0050879)3.92641862
63single strand break repair (GO:0000012)3.91809939
64* multicellular organismal development (GO:0007275)3.83831080
65meiosis I (GO:0007127)3.73906950
66membrane protein intracellular domain proteolysis (GO:0031293)3.72906702
67genitalia morphogenesis (GO:0035112)3.70972332
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.65219524
69glomerular visceral epithelial cell development (GO:0072015)3.64782496
70nucleosome disassembly (GO:0006337)3.56628674
71protein-DNA complex disassembly (GO:0032986)3.56628674
72microtubule nucleation (GO:0007020)3.54526813
73protein polyglutamylation (GO:0018095)3.52940051
74glomerular epithelial cell development (GO:0072310)3.52911522
75response to acidic pH (GO:0010447)3.50007444
76protein refolding (GO:0042026)3.45105564
77microtubule polymerization or depolymerization (GO:0031109)3.38023111
78coenzyme catabolic process (GO:0009109)3.35726039
79negative regulation of Rho protein signal transduction (GO:0035024)3.35197909
80cellular response to pH (GO:0071467)3.33920462
81protein K11-linked deubiquitination (GO:0035871)3.33791181
82glycolytic process (GO:0006096)3.32130777
83homeostasis of number of cells within a tissue (GO:0048873)3.23873944
84regulation of interleukin-13 production (GO:0032656)3.23668466
85regulation of spindle checkpoint (GO:0090231)3.23215009
86peptidyl-threonine dephosphorylation (GO:0035970)3.23173348
87polyamine biosynthetic process (GO:0006596)3.18786554
88meiotic cell cycle (GO:0051321)3.18739045
89carnitine transport (GO:0015879)3.16477292
90amino-acid betaine transport (GO:0015838)3.16477292
91protein localization to cilium (GO:0061512)3.14961937
92protein depolymerization (GO:0051261)3.12026524
93nucleus organization (GO:0006997)3.11582934
94cerebral cortex neuron differentiation (GO:0021895)3.10702546
95monoubiquitinated protein deubiquitination (GO:0035520)3.09137157
96sequestering of actin monomers (GO:0042989)3.06607574
97cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.06079127
98histone H3-K9 demethylation (GO:0033169)3.05051603
99polyol catabolic process (GO:0046174)3.01978558
100regulation of T-helper 2 cell differentiation (GO:0045628)3.00629015
101RNA localization (GO:0006403)2.98751388
102alditol metabolic process (GO:0019400)2.96493419
103mitochondrial fission (GO:0000266)2.93861005
104mitotic sister chromatid cohesion (GO:0007064)2.93365531
105regulation of phosphoprotein phosphatase activity (GO:0043666)2.93136117
106DNA conformation change (GO:0071103)2.92406492
107carnitine transmembrane transport (GO:1902603)2.92405182
108nucleoside diphosphate phosphorylation (GO:0006165)2.92002609
109antigen processing and presentation via MHC class Ib (GO:0002475)2.91280275
110positive regulation of guanylate cyclase activity (GO:0031284)2.90444178
111nuclear pore complex assembly (GO:0051292)2.87758092
112RNA destabilization (GO:0050779)2.87633747
113negative regulation of gene expression, epigenetic (GO:0045814)2.87245341
114positive regulation of macrophage activation (GO:0043032)2.82561984
115regulation of cilium assembly (GO:1902017)2.79953800
116mitotic G1 DNA damage checkpoint (GO:0031571)2.78503754
117intra-Golgi vesicle-mediated transport (GO:0006891)2.77766805
118microtubule-based movement (GO:0007018)2.77193813
119cilium organization (GO:0044782)2.76473098
120interferon-gamma secretion (GO:0072643)2.75768401
121regulation of somitogenesis (GO:0014807)2.75231183
122positive regulation of glycolytic process (GO:0045821)2.74724509
123receptor recycling (GO:0001881)2.74251510
124regulation of acrosome reaction (GO:0060046)2.73876257
125cilium assembly (GO:0042384)2.66831971
126mitochondrion degradation (GO:0000422)2.63050573
127meiotic cell cycle process (GO:1903046)2.61955409
128chromatin silencing (GO:0006342)2.61372331
129cellular component assembly involved in morphogenesis (GO:0010927)2.59958817
130negative regulation of organelle assembly (GO:1902116)2.59119838
131peptidyl-glutamic acid modification (GO:0018200)2.59067305
132cilium morphogenesis (GO:0060271)2.58883237
133intraciliary transport (GO:0042073)2.57201733
134GTP biosynthetic process (GO:0006183)2.51638302
135axoneme assembly (GO:0035082)2.51200303
136synapsis (GO:0007129)2.45962604
137sperm motility (GO:0030317)14.6362626
138fusion of sperm to egg plasma membrane (GO:0007342)14.0494029
139cell wall macromolecule catabolic process (GO:0016998)12.5732120
140cell wall macromolecule metabolic process (GO:0044036)12.5732120
141acrosome reaction (GO:0007340)12.3497656
142sperm-egg recognition (GO:0035036)11.5707603
143acrosome assembly (GO:0001675)10.9424654
144plasma membrane fusion (GO:0045026)10.7005038
145binding of sperm to zona pellucida (GO:0007339)10.6235657
146multicellular organism reproduction (GO:0032504)10.5149655
147cell-cell recognition (GO:0009988)10.3543103
148epithelial cilium movement (GO:0003351)10.1306550

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.87507332
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.39179962
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.36430349
4EZH2_22144423_ChIP-Seq_EOC_Human4.28928168
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.75858085
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.55739060
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.30317259
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.93899557
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.81072473
10VDR_22108803_ChIP-Seq_LS180_Human2.66625588
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.53348889
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.47104215
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.24502243
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24267676
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.14315000
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12871153
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.12225894
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09407910
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08859445
20ZNF274_21170338_ChIP-Seq_K562_Hela2.07918290
21DROSHA_22980978_ChIP-Seq_HELA_Human1.95151501
22FUS_26573619_Chip-Seq_HEK293_Human1.94702417
23RAC3_21632823_ChIP-Seq_H3396_Human1.88707045
24ERA_21632823_ChIP-Seq_H3396_Human1.81823475
25FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80491114
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.79511467
27CTCF_27219007_Chip-Seq_Bcells_Human1.78484397
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.78459522
29RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.75326083
30EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.75135750
31MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.73351222
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70854211
33SOX2_22085726_ChIP-Seq_NPCs_Mouse1.69947821
34* STAT1_17558387_ChIP-Seq_HELA_Human1.67634400
35TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.67256641
36TAF2_19829295_ChIP-Seq_ESCs_Human1.63680254
37BCL6_27268052_Chip-Seq_Bcells_Human1.61228021
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59993759
39WDR5_24793694_ChIP-Seq_LNCAP_Human1.59091710
40TDRD3_21172665_ChIP-Seq_MCF-7_Human1.56576375
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.56071393
42SMC4_20622854_ChIP-Seq_HELA_Human1.56061897
43MYC_19829295_ChIP-Seq_ESCs_Human1.55413708
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.51607868
45ER_23166858_ChIP-Seq_MCF-7_Human1.51462838
46* GATA3_21867929_ChIP-Seq_CD8_Mouse1.48390228
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.47779521
48E2F1_20622854_ChIP-Seq_HELA_Human1.47195874
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46852199
50FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46835129
51CBP_20019798_ChIP-Seq_JUKART_Human1.46748813
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46748813
53PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45462622
54OCT4_20526341_ChIP-Seq_ESCs_Human1.45281611
55TP63_22573176_ChIP-Seq_HFKS_Human1.45091411
56P68_20966046_ChIP-Seq_HELA_Human1.44748706
57KDM2B_26808549_Chip-Seq_REH_Human1.44720613
58PHF8_20622854_ChIP-Seq_HELA_Human1.43006905
59RBPJ_21746931_ChIP-Seq_IB4_Human1.42012496
60AR_25329375_ChIP-Seq_VCAP_Human1.41996822
61CBX2_22325352_ChIP-Seq_293T-Rex_Human1.41727756
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41062724
63HNFA_21074721_ChIP-Seq_CACO-2_Human1.40539086
64P53_21459846_ChIP-Seq_SAOS-2_Human1.40532869
65PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.40141655
66CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.38759968
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.38327978
68LXR_22292898_ChIP-Seq_THP-1_Human1.35976217
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33955791
70REST_21632747_ChIP-Seq_MESCs_Mouse1.33194775
71ETV1_20927104_ChIP-Seq_GIST48_Human1.33080840
72TP53_18474530_ChIP-ChIP_U2OS_Human1.33072426
73LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32928389
74* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32133684
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31096608
76P300_27268052_Chip-Seq_Bcells_Human1.30841810
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.28922094
78KAP1_22055183_ChIP-Seq_ESCs_Mouse1.28820574
79SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26848365
80GATA3_21867929_ChIP-Seq_TH1_Mouse1.26417211
81RAD21_21589869_ChIP-Seq_MESCs_Mouse1.26303898
82CEBPB_22108803_ChIP-Seq_LS180_Human1.25918135
83P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.25700995
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24485292
85KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23542510
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23436171
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23356821
88CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23261073
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22915597
90CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21666631
91GF1_26923725_Chip-Seq_HPCs_Mouse1.20337944
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.19511316
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.19247651
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.18007300
95RUNX_20019798_ChIP-Seq_JUKART_Human1.17401844
96BP1_19119308_ChIP-ChIP_Hs578T_Human1.16357859
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.16333175
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16280546
99TAF15_26573619_Chip-Seq_HEK293_Human1.15957585
100SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15716670
101SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.15387091
102RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15335748
103PHF8_20622853_ChIP-Seq_HELA_Human1.14542091
104GATA6_21074721_ChIP-Seq_CACO-2_Human1.13892898
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13634273
106ERG_20517297_ChIP-Seq_VCAP_Human1.13607784
107* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13472829
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.12836627
109SPI1_26923725_Chip-Seq_HPCs_Mouse1.12717396
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11986086
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11986086
112* P300_19829295_ChIP-Seq_ESCs_Human1.11902879
113* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11876141
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11873299
115MYC_27129775_Chip-Seq_CORNEA_Mouse1.11665986
116GATA1_19941827_ChIP-Seq_MEL86_Mouse1.10751925
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10683356
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10478175
119EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07155161
120SA1_27219007_Chip-Seq_Bcells_Human1.06892917
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06171786
122CTCF_20526341_ChIP-Seq_ESCs_Human1.05648616
123NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05455739
124RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05087284
125PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04596012
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04160045
127GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04104412
128NFYA_21822215_ChIP-Seq_K562_Human1.03927698
129ESET_19884257_ChIP-Seq_ESCs_Mouse1.03270317
130RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03184812
131EZH2_27294783_Chip-Seq_ESCs_Mouse1.03138268
132RUNX2_22187159_ChIP-Seq_PCA_Human1.03012197
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02651467
134TET1_21451524_ChIP-Seq_MESCs_Mouse1.02280407
135* SMRT_27268052_Chip-Seq_Bcells_Human1.02148173
136YY1_22570637_ChIP-Seq_MALME-3M_Human1.02135826
137* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02077781
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01986430
139RARA_24833708_ChIP-Seq_LIVER_Mouse1.01668254
140SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01217125
141SOX2_19829295_ChIP-Seq_ESCs_Human1.01216858
142NANOG_19829295_ChIP-Seq_ESCs_Human1.01216858
143PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00939164
144STAT3_23295773_ChIP-Seq_U87_Human1.00416076
145* SMAD4_21741376_ChIP-Seq_HESCs_Human1.00339820
146SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99870215
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99286115
148* SMAD4_21799915_ChIP-Seq_A2780_Human0.99228729
149CRX_20693478_ChIP-Seq_RETINA_Mouse0.98868117
150* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98753421
151SOX11_22085726_ChIP-Seq_ESNs_Mouse0.97727960
152KLF4_19829295_ChIP-Seq_ESCs_Human0.97673966
153ELF1_20517297_ChIP-Seq_JURKAT_Human0.95355999
154PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94970387
155NANOG_20526341_ChIP-Seq_ESCs_Human0.94814475
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94583858
157NANOG_18555785_Chip-Seq_ESCs_Mouse0.94433767
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93972304
159NFYB_21822215_ChIP-Seq_K562_Human0.93920486
160BCOR_27268052_Chip-Seq_Bcells_Human0.92190552
161FLI1_21867929_ChIP-Seq_CD8_Mouse0.91983958
162SMAD4_21741376_ChIP-Seq_EPCs_Human0.91031337
163LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89947018
164SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88502932
165OCT4_18555785_Chip-Seq_ESCs_Mouse0.88133369
166SOX2_21211035_ChIP-Seq_LN229_Human0.87963986
167SMAD3_21741376_ChIP-Seq_ESCs_Human0.87703353
168TBL1_22424771_ChIP-Seq_293T_Human0.87063244
169CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86849753
170STAT3_18555785_ChIP-Seq_MESCs_Mouse0.85593636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.09393183
2MP0001929_abnormal_gametogenesis5.44235532
3MP0008877_abnormal_DNA_methylation3.68912001
4MP0002161_abnormal_fertility/fecundity3.32411527
5MP0001348_abnormal_lacrimal_gland3.30386918
6MP0002210_abnormal_sex_determination3.23040890
7MP0005670_abnormal_white_adipose3.16418647
8MP0001145_abnormal_male_reproductive2.75985062
9MP0000653_abnormal_sex_gland2.37813471
10MP0002653_abnormal_ependyma_morphology2.35171822
11MP0000678_abnormal_parathyroid_gland2.24456206
12MP0003718_maternal_effect2.15164129
13MP0005410_abnormal_fertilization16.6716169
14MP0002132_abnormal_respiratory_system1.78986170
15MP0005379_endocrine/exocrine_gland_phen1.64691343
16MP0001485_abnormal_pinna_reflex1.62412098
17MP0005423_abnormal_somatic_nervous1.60578665
18MP0005623_abnormal_meninges_morphology1.55156590
19MP0005310_abnormal_salivary_gland1.54531339
20MP0001486_abnormal_startle_reflex1.45710568
21MP0004233_abnormal_muscle_weight1.41009829
22MP0002160_abnormal_reproductive_system1.40633784
23MP0003646_muscle_fatigue1.37644020
24MP0002249_abnormal_larynx_morphology1.33404921
25MP0002282_abnormal_trachea_morphology1.32550276
26MP0005451_abnormal_body_composition1.30659050
27MP0001765_abnormal_ion_homeostasis1.22258254
28MP0004859_abnormal_synaptic_plasticity1.21973601
29MP0009053_abnormal_anal_canal1.20341118
30MP0002138_abnormal_hepatobiliary_system1.10115769
31MP0001963_abnormal_hearing_physiology1.08328950
32MP0002735_abnormal_chemical_nociception1.04988237
33MP0003878_abnormal_ear_physiology1.04421811
34MP0005377_hearing/vestibular/ear_phenot1.04421811
35MP0002822_catalepsy1.04220560
36MP0004510_myositis1.00415348
37MP0002127_abnormal_cardiovascular_syste0.98092988
38MP0005395_other_phenotype0.98087579
39MP0000026_abnormal_inner_ear0.93898299
40MP0008995_early_reproductive_senescence0.92435688
41MP0001984_abnormal_olfaction0.91010357
42MP0002234_abnormal_pharynx_morphology0.90455723
43MP0008569_lethality_at_weaning0.88044006
44MP0000955_abnormal_spinal_cord0.82262268
45MP0005647_abnormal_sex_gland0.81458532
46MP0005248_abnormal_Harderian_gland0.78825062
47MP0003115_abnormal_respiratory_system0.75960974
48MP0005636_abnormal_mineral_homeostasis0.75841807
49MP0009046_muscle_twitch0.75569239
50MP0005083_abnormal_biliary_tract0.73467788
51MP0002067_abnormal_sensory_capabilities0.73317654
52MP0005666_abnormal_adipose_tissue0.71105971
53MP0000681_abnormal_thyroid_gland0.69723747
54MP0002557_abnormal_social/conspecific_i0.66896082
55MP0005389_reproductive_system_phenotype0.66456656
56MP0000049_abnormal_middle_ear0.65743657
57MP0001905_abnormal_dopamine_level0.65542685
58MP0008058_abnormal_DNA_repair0.63399029
59MP0004085_abnormal_heartbeat0.62846831
60MP0009697_abnormal_copulation0.58869513
61MP0003329_amyloid_beta_deposits0.58398891
62MP0001324_abnormal_eye_pigmentation0.58083499
63MP0000569_abnormal_digit_pigmentation0.57984187
64MP0003011_delayed_dark_adaptation0.57690379
65MP0005167_abnormal_blood-brain_barrier0.56676274
66MP0002733_abnormal_thermal_nociception0.54878687
67MP0001879_abnormal_lymphatic_vessel0.54647981
68MP0004036_abnormal_muscle_relaxation0.54189426
69MP0002572_abnormal_emotion/affect_behav0.53617541
70MP0002736_abnormal_nociception_after0.52941079
71MP0001764_abnormal_homeostasis0.52485580
72MP0001270_distended_abdomen0.50285786
73MP0001293_anophthalmia0.50254845
74MP0001666_abnormal_nutrient_absorption0.49610622
75MP0002272_abnormal_nervous_system0.48502140
76MP0003077_abnormal_cell_cycle0.48489730
77MP0000358_abnormal_cell_content/0.48145726
78MP0002269_muscular_atrophy0.47517663
79MP0003699_abnormal_female_reproductive0.44742536
80MP0004484_altered_response_of0.43724847
81MP0001440_abnormal_grooming_behavior0.43633647
82MP0002928_abnormal_bile_duct0.43346838
83MP0003137_abnormal_impulse_conducting0.43258866
84MP0009745_abnormal_behavioral_response0.43031373
85MP0005367_renal/urinary_system_phenotyp0.42841851
86MP0000516_abnormal_urinary_system0.42841851
87MP0000534_abnormal_ureter_morphology0.42436121
88MP0000230_abnormal_systemic_arterial0.42107398
89MP0002734_abnormal_mechanical_nocicepti0.41025717
90MP0005535_abnormal_body_temperature0.40723353
91MP0003950_abnormal_plasma_membrane0.40564871
92MP0000249_abnormal_blood_vessel0.40462550
93MP0002139_abnormal_hepatobiliary_system0.40027725
94MP0000003_abnormal_adipose_tissue0.40016240
95MP0009115_abnormal_fat_cell0.39887574
96MP0000613_abnormal_salivary_gland0.39326167
97MP0001970_abnormal_pain_threshold0.38838770
98MP0001501_abnormal_sleep_pattern0.38669367
99MP0009278_abnormal_bone_marrow0.37682532
100MP0005084_abnormal_gallbladder_morpholo0.37533835
101MP0005397_hematopoietic_system_phenotyp0.36234735
102MP0001545_abnormal_hematopoietic_system0.36234735
103MP0005551_abnormal_eye_electrophysiolog0.35860477
104MP0004019_abnormal_vitamin_homeostasis0.35192991
105MP0005253_abnormal_eye_physiology0.34819006
106MP0003879_abnormal_hair_cell0.34545151
107MP0002971_abnormal_brown_adipose0.34272832
108MP0000470_abnormal_stomach_morphology0.33901276
109MP0005408_hypopigmentation0.33708568
110MP0000604_amyloidosis0.33338577
111MP0003635_abnormal_synaptic_transmissio0.32722078
112MP0003091_abnormal_cell_migration0.31645677
113MP0005391_vision/eye_phenotype0.30865872
114MP0003942_abnormal_urinary_system0.30571521
115MP0002295_abnormal_pulmonary_circulatio0.29919308
116MP0005375_adipose_tissue_phenotype0.29541025
117MP0003633_abnormal_nervous_system0.29333878
118MP0010094_abnormal_chromosome_stability0.29324149
119MP0001968_abnormal_touch/_nociception0.29130317
120MP0006036_abnormal_mitochondrial_physio0.27735150
121MP0004270_analgesia0.27500037
122MP0003631_nervous_system_phenotype0.25428555
123MP0004043_abnormal_pH_regulation0.24342647
124MP0004742_abnormal_vestibular_system0.24295850
125MP0004811_abnormal_neuron_physiology0.24117075
126MP0004133_heterotaxia0.23531057
127MP0003948_abnormal_gas_homeostasis0.22937675
128MP0003045_fibrosis0.22836152
129MP0001119_abnormal_female_reproductive0.22556483
130MP0002092_abnormal_eye_morphology0.21784956
131MP0003111_abnormal_nucleus_morphology0.21442271
132MP0005365_abnormal_bile_salt0.20675068
133MP0003861_abnormal_nervous_system0.20660555
134MP0002152_abnormal_brain_morphology0.19894754
135MP0002169_no_abnormal_phenotype0.19823376
136MP0001730_embryonic_growth_arrest0.19713481
137MP0008875_abnormal_xenobiotic_pharmacok0.19700277
138MP0002693_abnormal_pancreas_physiology0.19607088
139MP0002873_normal_phenotype0.19591629
140MP0000751_myopathy0.19262656
141MP0002118_abnormal_lipid_homeostasis0.18183188
142MP0003786_premature_aging0.17522227
143MP0002229_neurodegeneration0.17129535
144MP0004145_abnormal_muscle_electrophysio0.17117207
145MP0010329_abnormal_lipoprotein_level0.16854147
146MP0001661_extended_life_span0.16396594
147MP0001849_ear_inflammation0.16369845
148MP0005319_abnormal_enzyme/_coenzyme0.15710556
149MP0008961_abnormal_basal_metabolism0.15451737
150MP0003252_abnormal_bile_duct0.14162730
151MP0002108_abnormal_muscle_morphology0.14019729
152MP0001727_abnormal_embryo_implantation0.12930297
153MP0003787_abnormal_imprinting0.12847921
154MP0003632_abnormal_nervous_system0.12817489
155MP0002796_impaired_skin_barrier0.12383248
156MP0000001_mammalian_phenotype0.12344313
157MP0000462_abnormal_digestive_system0.12322600
158MP0003959_abnormal_lean_body0.12139631
159MP0006035_abnormal_mitochondrial_morpho0.12022511

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.13030341
2Abnormal respiratory motile cilium morphology (HP:0005938)9.13030341
3Abnormal respiratory motile cilium physiology (HP:0012261)9.12497094
4Severe visual impairment (HP:0001141)7.89849179
5Rhinitis (HP:0012384)7.36942467
6Infertility (HP:0000789)7.16074084
7Chronic bronchitis (HP:0004469)7.14702897
8Abnormal ciliary motility (HP:0012262)7.09928174
9Nasal polyposis (HP:0100582)6.43155302
10Chronic hepatic failure (HP:0100626)5.59877400
11Abnormality of the nasal mucosa (HP:0000433)5.29807073
12Male infertility (HP:0003251)4.97271628
13Attenuation of retinal blood vessels (HP:0007843)4.85758848
14Hyperkalemia (HP:0002153)4.83976258
15Bony spicule pigmentary retinopathy (HP:0007737)4.81124064
16Bronchitis (HP:0012387)4.69148555
17Resting tremor (HP:0002322)4.63023563
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.47535759
19Bronchiectasis (HP:0002110)4.40992822
20Cone-rod dystrophy (HP:0000548)4.28756370
21Abnormality of macular pigmentation (HP:0008002)4.26596369
22Nephronophthisis (HP:0000090)4.08890274
23Abnormal rod and cone electroretinograms (HP:0008323)3.77666779
24Hypoalphalipoproteinemia (HP:0003233)3.75471408
25Abnormal spermatogenesis (HP:0008669)3.68395569
26Progressive sensorineural hearing impairment (HP:0000408)3.60906108
27Hypoplasia of the thymus (HP:0000778)3.58358324
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.46589328
29Menstrual irregularities (HP:0000858)3.37884205
30Recurrent otitis media (HP:0000403)3.35247006
31Postural instability (HP:0002172)3.18869496
32Recurrent sinusitis (HP:0011108)3.18316376
33Abnormality of the renal medulla (HP:0100957)3.12682017
34Renovascular hypertension (HP:0100817)3.11752279
35Hypoplastic ischia (HP:0003175)3.11700344
36Enlarged epiphyses (HP:0010580)3.09307641
37Recurrent bronchitis (HP:0002837)3.05445661
38Amelogenesis imperfecta (HP:0000705)3.00948093
39Impulsivity (HP:0100710)2.98817263
40Insulin-resistant diabetes mellitus (HP:0000831)2.96806569
41Tubulointerstitial nephritis (HP:0001970)2.88834364
42Abnormality of the ischium (HP:0003174)2.79571685
43Portal hypertension (HP:0001409)2.79478620
44Abnormality of dental color (HP:0011073)2.74479406
45Progressive cerebellar ataxia (HP:0002073)2.73706613
46Abnormal gallbladder physiology (HP:0012438)2.69709330
47Cholecystitis (HP:0001082)2.69709330
48Generalized aminoaciduria (HP:0002909)2.66310886
49Abnormality of potassium homeostasis (HP:0011042)2.64470866
50Unilateral renal agenesis (HP:0000122)2.62929247
51Tubular atrophy (HP:0000092)2.57904156
52Abnormality of the hepatic vasculature (HP:0006707)2.56207311
53Tubulointerstitial abnormality (HP:0001969)2.55117954
54Dyschromatopsia (HP:0007641)2.54921069
55Abnormality of the aortic arch (HP:0012303)2.52456688
56Abnormality of the costochondral junction (HP:0000919)2.50466929
57Gonadotropin excess (HP:0000837)2.49186895
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.43970582
59Increased purine levels (HP:0004368)2.31634479
60Hyperuricemia (HP:0002149)2.31634479
61Abnormality of midbrain morphology (HP:0002418)2.30543617
62Molar tooth sign on MRI (HP:0002419)2.30543617
63Progressive hearing impairment (HP:0001730)2.29674478
64Choroideremia (HP:0001139)2.26023095
65Azoospermia (HP:0000027)2.25562889
66Myokymia (HP:0002411)2.23495739
67Decreased central vision (HP:0007663)2.18541981
68Medial flaring of the eyebrow (HP:0010747)2.15777911
69Abnormality of the parathyroid morphology (HP:0011766)2.15462043
70Osteomalacia (HP:0002749)2.14718780
71Spastic tetraparesis (HP:0001285)2.13500795
72Ventricular tachycardia (HP:0004756)2.12743445
73Flattened epiphyses (HP:0003071)2.12169448
74Tubulointerstitial fibrosis (HP:0005576)2.12100572
75Subcapsular cataract (HP:0000523)2.09545378
76Polyuria (HP:0000103)2.07300289
77Recurrent pneumonia (HP:0006532)2.07213032
78Focal segmental glomerulosclerosis (HP:0000097)2.06708615
79Absent/shortened dynein arms (HP:0200106)13.3167449
80Dynein arm defect of respiratory motile cilia (HP:0012255)13.3167449
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9697424
82Hyponatremia (HP:0002902)1.92631565
83Widely patent fontanelles and sutures (HP:0004492)1.90610381
84Heterotopia (HP:0002282)1.89274121
85Hypophosphatemic rickets (HP:0004912)1.89186250
86Intellectual disability, moderate (HP:0002342)1.88431588
87Optic nerve hypoplasia (HP:0000609)1.87456692
88Abnormality of the epiphysis of the femoral head (HP:0010574)1.86860938
89Hemorrhage of the eye (HP:0011885)1.86830845
90Bile duct proliferation (HP:0001408)1.85995743
91Abnormal biliary tract physiology (HP:0012439)1.85995743
92Hypolipoproteinemia (HP:0010981)1.85866053
93Renal Fanconi syndrome (HP:0001994)1.82228152
94Epiphyseal dysplasia (HP:0002656)1.80683583
95Neurofibrillary tangles (HP:0002185)1.80532058
96Insulin resistance (HP:0000855)1.77582567
97Bradycardia (HP:0001662)1.76982787
98Tetany (HP:0001281)1.74580939
99Bell-shaped thorax (HP:0001591)1.73758177
100Photophobia (HP:0000613)1.73504479
101Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.73111932
102Abnormality of femoral epiphyses (HP:0006499)1.73111932
103Stage 5 chronic kidney disease (HP:0003774)1.72254060
104Postaxial foot polydactyly (HP:0001830)1.71568227
105Upper limb muscle weakness (HP:0003484)1.71081258
106Abnormality of chloride homeostasis (HP:0011422)1.69494232
107Recurrent corneal erosions (HP:0000495)1.68778222
108Flat capital femoral epiphysis (HP:0003370)1.66933454
109Short ribs (HP:0000773)1.63311481
110Abnormal drinking behavior (HP:0030082)1.63028815
111Polydipsia (HP:0001959)1.63028815
112Congenital hepatic fibrosis (HP:0002612)1.60088716
113Abnormality of renal excretion (HP:0011036)1.59990965
114Hypoplasia of the capital femoral epiphysis (HP:0003090)1.58147301
115Decreased electroretinogram (ERG) amplitude (HP:0000654)1.57161042
116Asymmetric septal hypertrophy (HP:0001670)1.57053463
117Abnormality of the renal cortex (HP:0011035)1.56880715
118Double outlet right ventricle (HP:0001719)1.54246397
119Congenital malformation of the right heart (HP:0011723)1.54246397
120Abnormality of permanent molar morphology (HP:0011071)1.53783694
121Abnormality of the dental root (HP:0006486)1.53783694
122Taurodontia (HP:0000679)1.53783694
123Abnormality of dentin (HP:0010299)1.53667023
124Cerebral inclusion bodies (HP:0100314)1.50386982
125Hypercholesterolemia (HP:0003124)1.48146274
126Bundle branch block (HP:0011710)1.47713976
127Renal dysplasia (HP:0000110)1.44238602
128Hemiparesis (HP:0001269)1.43486546
129Fibular hypoplasia (HP:0003038)1.43348997
130Aplasia/Hypoplasia of the lens (HP:0008063)1.42434547
131Abnormality of the dental pulp (HP:0006479)1.42267162
132Abnormality of molar (HP:0011077)1.41575283
133Abnormality of molar morphology (HP:0011070)1.41575283
134Cystic liver disease (HP:0006706)1.41098657
135Oculomotor apraxia (HP:0000657)1.39116864
136Abnormality of the lower motor neuron (HP:0002366)1.35107910
137Postaxial hand polydactyly (HP:0001162)1.34977297
138Deformed sella turcica (HP:0002681)1.34395746
139Truncal obesity (HP:0001956)1.32641963
140Sensory axonal neuropathy (HP:0003390)1.32352116
141Abnormal urine output (HP:0012590)1.31720403
142Constricted visual fields (HP:0001133)1.30186868
143Exercise-induced myalgia (HP:0003738)1.29306914
144Easy fatigability (HP:0003388)1.29306789
145Broad distal phalanx of finger (HP:0009836)1.29175008
146Facial cleft (HP:0002006)1.27298892
147Myoglobinuria (HP:0002913)1.27142843
148Loss of speech (HP:0002371)1.26486386
149Absent frontal sinuses (HP:0002688)1.23990035
150Absent epiphyses (HP:0010577)1.23142232
151Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.23142232
152Neoplasm of the heart (HP:0100544)1.20621833
153Vascular calcification (HP:0004934)1.19565717
154Abnormality of the neuromuscular junction (HP:0003398)1.18433412
155Fatigable weakness (HP:0003473)1.18433412
156Amyotrophic lateral sclerosis (HP:0007354)1.18173236
157Hyporeflexia of lower limbs (HP:0002600)1.17921813
158Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.17534794
159Chronic sinusitis (HP:0011109)1.17470929
160Facial shape deformation (HP:0011334)1.16958240
161Potter facies (HP:0002009)1.16958240
162Short thorax (HP:0010306)1.16344160
163Cerebellar dysplasia (HP:0007033)1.14983950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.77144815
2PDK37.77144815
3TESK16.71999763
4PRKD35.44596245
5PDK25.02550786
6ICK4.78501730
7DDR24.09300155
8BRD43.88406524
9INSRR3.70266582
10MAP4K23.17645629
11PLK23.15387646
12WNK42.32322084
13PTK2B2.21414928
14STK392.14599433
15PNCK2.13863052
16DYRK1B1.96655229
17PIK3CG1.86166647
18STK381.82481246
19MST1R1.75092610
20NEK21.46366586
21PDK11.22067134
22CDK71.14778751
23KSR20.98432778
24SIK20.94189315
25WNK10.93701764
26TYRO30.93232057
27CAMK1D0.90224551
28MAP3K90.87484359
29MAPK150.85354204
30DYRK30.85138419
31LATS10.80767720
32PDPK10.80102158
33RIPK40.77814338
34CAMK1G0.74766484
35IRAK10.74444773
36BRAF0.72126604
37EEF2K0.70679185
38MAP3K110.69814555
39TESK20.68712362
40MAP2K20.67817544
41PASK0.65578289
42CCNB10.64738433
43MAP3K20.63319063
44RPS6KA20.62231561
45STK30.61556220
46MAP2K60.59984990
47LATS20.59258150
48UHMK10.57698060
49CAMK10.57479397
50TTK0.56263012
51SGK4940.55940316
52SGK2230.55940316
53CDK30.52864164
54LMTK20.51425444
55CHEK20.50669810
56ROCK10.50508956
57PINK10.50442977
58PRKAA20.48256122
59MAP3K80.47099681
60PAK10.46107185
61BMPR1B0.43709072
62PAK20.43593258
63NTRK20.43516953
64TIE10.42201302
65MAPK10.40553531
66IRAK20.40466126
67PRKCG0.36415327
68CHEK10.36081221
69MARK10.32669695
70MARK20.32441314
71MAPKAPK50.31766633
72MAP3K100.31752310
73STK38L0.31543188
74MUSK0.31295559
75MTOR0.31062581
76PAK40.30367130
77SGK10.30090151
78CAMK40.29586935
79RPS6KC10.29314121
80RPS6KL10.29314121
81NTRK30.26935773
82RPS6KA60.26772426
83NEK60.26724094
84ATM0.24866202
85CAMKK10.23403076
86MET0.23036967
87MAPK140.22904839
88ARAF0.22503611
89ATR0.21558778
90JAK30.21488472
91MAPK100.20768304
92PRKCZ0.20109636
93SGK20.19375519
94PRKAA10.18766358
95PRKCQ0.17793445
96WEE10.16476772
97CDK150.15809961
98AKT10.14193976
99TNIK0.13885818
100RPS6KB10.13464427
101CDK180.12856183
102PLK40.12807413
103ACVR1B0.12516896
104MAPK110.12492815
105CDK11A0.11939372
106MINK10.09874327
107PRKACA0.09576101
108BLK0.09560888
109BRSK20.09408810
110OXSR10.09388954
111CDK120.08883591
112GSK3B0.08372543
113CSNK1D0.07849556
114STK100.07789832
115RPS6KA10.07432758
116CDK140.07366160
117EPHB10.06849208
118SGK30.06840643
119PRKG20.06717673
120CDK60.06475726
121FER0.06145206
122PLK10.06079082
123CSNK2A10.04758505
124MAPK90.04501028
125BRSK10.03871400
126EGFR0.03682184
127AKT30.03578513
128CSF1R0.03535452
129PKN10.03463297
130CDC70.02844132
131PRKCB0.02622000
132PRKACG0.02422436
133CAMK2A0.02409645
134PRKCD0.02263654
135MAPK80.02181281
136CDK10.02103380
137PIM10.01832819
138PRKG10.01792662
139CDK20.01523245
140PRKCA0.01359855
141STK110.01055974
142MAP3K10.00903595
143PDGFRB0.00157998
144CSNK2A2-1.8602984
145FRK-0.0259914
146CDK4-0.0237182
147RPS6KA3-0.0185907
148PAK6-0.0121920
149MAP3K4-0.0113846
150PRKACB-0.0095279
151CLK1-0.0077316
152MARK3-0.0041129
153TRIB3-0.0040681
154RIPK1-0.0003131

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.43359109
2Fatty acid biosynthesis_Homo sapiens_hsa000614.87933258
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.51639614
4Olfactory transduction_Homo sapiens_hsa047403.47952895
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.22282799
6Pyruvate metabolism_Homo sapiens_hsa006203.09132092
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.01179284
8Linoleic acid metabolism_Homo sapiens_hsa005912.97561407
9Vitamin B6 metabolism_Homo sapiens_hsa007502.82149618
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.72600170
11Butanoate metabolism_Homo sapiens_hsa006502.50381345
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.49601783
13Glucagon signaling pathway_Homo sapiens_hsa049222.40241183
14Propanoate metabolism_Homo sapiens_hsa006402.32895357
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.15078409
16PPAR signaling pathway_Homo sapiens_hsa033202.05175682
17Glycerolipid metabolism_Homo sapiens_hsa005612.04031044
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.01252378
19Selenocompound metabolism_Homo sapiens_hsa004501.89630061
20Basal transcription factors_Homo sapiens_hsa030221.82030735
21Fructose and mannose metabolism_Homo sapiens_hsa000511.73504794
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.70753657
23Mineral absorption_Homo sapiens_hsa049781.70732363
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.69613352
25Fatty acid degradation_Homo sapiens_hsa000711.68834306
26Fatty acid metabolism_Homo sapiens_hsa012121.64599565
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58818113
28Dorso-ventral axis formation_Homo sapiens_hsa043201.58390023
29Phenylalanine metabolism_Homo sapiens_hsa003601.54003393
30Fat digestion and absorption_Homo sapiens_hsa049751.52560388
31Oocyte meiosis_Homo sapiens_hsa041141.46807993
32Carbon metabolism_Homo sapiens_hsa012001.36473589
33Amphetamine addiction_Homo sapiens_hsa050311.35713792
34Pentose phosphate pathway_Homo sapiens_hsa000301.34829123
35Ether lipid metabolism_Homo sapiens_hsa005651.34491441
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28365969
37Type I diabetes mellitus_Homo sapiens_hsa049401.27629291
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.23853148
39Cardiac muscle contraction_Homo sapiens_hsa042601.23508926
40Phototransduction_Homo sapiens_hsa047441.21092166
41Allograft rejection_Homo sapiens_hsa053301.16215452
42Autoimmune thyroid disease_Homo sapiens_hsa053201.14680615
43Antigen processing and presentation_Homo sapiens_hsa046121.13202425
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09284256
45ABC transporters_Homo sapiens_hsa020101.04121975
46Hedgehog signaling pathway_Homo sapiens_hsa043401.03603030
47Graft-versus-host disease_Homo sapiens_hsa053321.02280418
48Renin secretion_Homo sapiens_hsa049241.02132580
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.00349015
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00204462
51Arginine and proline metabolism_Homo sapiens_hsa003300.99571801
52Glutathione metabolism_Homo sapiens_hsa004800.96573951
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96176900
54Morphine addiction_Homo sapiens_hsa050320.95381733
55Fanconi anemia pathway_Homo sapiens_hsa034600.92940817
56Arginine biosynthesis_Homo sapiens_hsa002200.91937734
57Biosynthesis of amino acids_Homo sapiens_hsa012300.91046488
58Arachidonic acid metabolism_Homo sapiens_hsa005900.90139064
59Thyroid hormone synthesis_Homo sapiens_hsa049180.89610360
60Purine metabolism_Homo sapiens_hsa002300.89128569
61Bile secretion_Homo sapiens_hsa049760.88006197
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.87751760
63Chemical carcinogenesis_Homo sapiens_hsa052040.87246053
64Insulin secretion_Homo sapiens_hsa049110.87008085
65mRNA surveillance pathway_Homo sapiens_hsa030150.86814456
66Viral myocarditis_Homo sapiens_hsa054160.86562534
67Collecting duct acid secretion_Homo sapiens_hsa049660.86047248
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84402455
69Huntingtons disease_Homo sapiens_hsa050160.80705646
70Estrogen signaling pathway_Homo sapiens_hsa049150.78326482
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.70264965
72Influenza A_Homo sapiens_hsa051640.69550911
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68819259
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68409690
75Salivary secretion_Homo sapiens_hsa049700.66747769
76Nicotine addiction_Homo sapiens_hsa050330.66484892
77Tyrosine metabolism_Homo sapiens_hsa003500.66369365
78Glutamatergic synapse_Homo sapiens_hsa047240.66011533
79Long-term potentiation_Homo sapiens_hsa047200.64038248
80Protein digestion and absorption_Homo sapiens_hsa049740.63030396
81RNA transport_Homo sapiens_hsa030130.62945418
82Serotonergic synapse_Homo sapiens_hsa047260.60406604
83Legionellosis_Homo sapiens_hsa051340.59655225
84Pancreatic secretion_Homo sapiens_hsa049720.59237798
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58596355
86Renin-angiotensin system_Homo sapiens_hsa046140.57012615
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.56901655
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56560117
89Sulfur metabolism_Homo sapiens_hsa009200.54142261
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53105870
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53096743
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50805961
93Retinol metabolism_Homo sapiens_hsa008300.50803586
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.49822730
95Gastric acid secretion_Homo sapiens_hsa049710.49764544
96Calcium signaling pathway_Homo sapiens_hsa040200.49467544
97Nitrogen metabolism_Homo sapiens_hsa009100.48063821
98MAPK signaling pathway_Homo sapiens_hsa040100.47978036
99Tight junction_Homo sapiens_hsa045300.46015637
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45780214
101Endocytosis_Homo sapiens_hsa041440.45502884
102Synaptic vesicle cycle_Homo sapiens_hsa047210.44558728
103AMPK signaling pathway_Homo sapiens_hsa041520.42738311
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.41365828
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40607757
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40447355
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38899991
108Cholinergic synapse_Homo sapiens_hsa047250.35611859
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35403087
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35307841
111Inositol phosphate metabolism_Homo sapiens_hsa005620.34766809
112Metabolic pathways_Homo sapiens_hsa011000.34499798
113Systemic lupus erythematosus_Homo sapiens_hsa053220.33125494
114Taste transduction_Homo sapiens_hsa047420.33096720
115GABAergic synapse_Homo sapiens_hsa047270.32675158
116cAMP signaling pathway_Homo sapiens_hsa040240.32663239
117Acute myeloid leukemia_Homo sapiens_hsa052210.30680236
118Oxytocin signaling pathway_Homo sapiens_hsa049210.29204255
119VEGF signaling pathway_Homo sapiens_hsa043700.25737043
120Circadian entrainment_Homo sapiens_hsa047130.24199664
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23887197
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.23862467
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21821753
124Cocaine addiction_Homo sapiens_hsa050300.19943772
125ECM-receptor interaction_Homo sapiens_hsa045120.19728182
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17839036
127Pyrimidine metabolism_Homo sapiens_hsa002400.16972133
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.15883206
129Viral carcinogenesis_Homo sapiens_hsa052030.15437942
130Prolactin signaling pathway_Homo sapiens_hsa049170.14388168
131Type II diabetes mellitus_Homo sapiens_hsa049300.12648590
132Complement and coagulation cascades_Homo sapiens_hsa046100.11664436
133Alcoholism_Homo sapiens_hsa050340.10188377
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.10043576
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09714783
136Vitamin digestion and absorption_Homo sapiens_hsa049770.09550121
137HIF-1 signaling pathway_Homo sapiens_hsa040660.08051183
138Insulin resistance_Homo sapiens_hsa049310.06764198
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.06307724

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