ODF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.96750707
2epithelial cilium movement (GO:0003351)9.93288538
3axonemal dynein complex assembly (GO:0070286)9.89544139
4* spermatid development (GO:0007286)9.26118087
5motile cilium assembly (GO:0044458)9.11405531
6reproduction (GO:0000003)8.98969079
7regulation of cilium movement (GO:0003352)8.73810855
8cilium movement (GO:0003341)8.23974313
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.62361925
10piRNA metabolic process (GO:0034587)7.52578843
11male meiosis (GO:0007140)7.36030894
12single fertilization (GO:0007338)7.30131352
13synaptonemal complex organization (GO:0070193)7.27340352
14sperm capacitation (GO:0048240)7.23125545
15synaptonemal complex assembly (GO:0007130)7.07122101
16negative regulation of inclusion body assembly (GO:0090084)6.92780681
17microtubule depolymerization (GO:0007019)6.54785442
18spermatogenesis (GO:0007283)6.53438262
19male gamete generation (GO:0048232)6.51197284
20fertilization (GO:0009566)6.27745175
21organic cation transport (GO:0015695)6.11518642
22gamete generation (GO:0007276)5.99283651
23regulation of inclusion body assembly (GO:0090083)5.76654557
24ventricular system development (GO:0021591)5.43510869
25* cellular process involved in reproduction in multicellular organism (GO:0022412)5.28567302
26* germ cell development (GO:0007281)5.26238315
27calcium ion-dependent exocytosis (GO:0017156)5.24965774
28male meiosis I (GO:0007141)5.20489209
29regulation of microtubule-based movement (GO:0060632)5.20223536
30centriole replication (GO:0007099)5.16487959
31mitotic chromosome condensation (GO:0007076)5.14784153
32nucleosome disassembly (GO:0006337)5.04215885
33protein-DNA complex disassembly (GO:0032986)5.04215885
34chromosome condensation (GO:0030261)5.00009639
35chromosome organization involved in meiosis (GO:0070192)4.90140778
36cell recognition (GO:0008037)4.86041550
37DNA methylation involved in gamete generation (GO:0043046)4.80914831
38DNA packaging (GO:0006323)4.77254777
39multicellular organismal reproductive process (GO:0048609)4.72801086
40microtubule severing (GO:0051013)4.72771123
41seminiferous tubule development (GO:0072520)4.63190587
42mitotic sister chromatid segregation (GO:0000070)4.56882068
43glycerol ether metabolic process (GO:0006662)4.55585360
44meiotic nuclear division (GO:0007126)4.49399242
45spermatid nucleus differentiation (GO:0007289)4.47533365
46sister chromatid segregation (GO:0000819)4.47486176
47left/right pattern formation (GO:0060972)4.45288030
48meiosis I (GO:0007127)4.24835172
49DNA conformation change (GO:0071103)4.21277277
50ether metabolic process (GO:0018904)4.20568352
51chaperone-mediated protein complex assembly (GO:0051131)4.14214630
52pore complex assembly (GO:0046931)4.06728306
53DNA topological change (GO:0006265)4.02587396
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.82888912
55DNA unwinding involved in DNA replication (GO:0006268)3.78502326
56genitalia morphogenesis (GO:0035112)3.76973513
57monoubiquitinated protein deubiquitination (GO:0035520)3.76196410
58protein polyglutamylation (GO:0018095)3.72865368
59meiotic chromosome segregation (GO:0045132)3.72456511
60* multicellular organismal development (GO:0007275)3.71911707
61regulation of histone H3-K27 methylation (GO:0061085)3.71515069
62single strand break repair (GO:0000012)3.66691720
63meiotic cell cycle (GO:0051321)3.65485966
64regulation of mitotic spindle organization (GO:0060236)3.56386792
65mitotic nuclear envelope disassembly (GO:0007077)3.55778235
66nuclear envelope disassembly (GO:0051081)3.50804795
67membrane disassembly (GO:0030397)3.50804795
68phosphatidylethanolamine biosynthetic process (GO:0006646)3.48960080
69negative regulation of histone methylation (GO:0031061)3.48602591
70regulation of spindle checkpoint (GO:0090231)3.47771231
71sexual reproduction (GO:0019953)3.46255243
72protein localization to cilium (GO:0061512)3.46174494
73histone H3-K9 demethylation (GO:0033169)3.45093847
74DNA ligation (GO:0006266)3.39052047
75mitotic sister chromatid cohesion (GO:0007064)3.38731546
76protein refolding (GO:0042026)3.38333841
77microtubule polymerization or depolymerization (GO:0031109)3.35508151
78rRNA methylation (GO:0031167)3.34462869
79mitotic metaphase plate congression (GO:0007080)3.31226991
80glycolytic process (GO:0006096)3.29479654
81regulation of centrosome cycle (GO:0046605)3.27597143
82nucleus organization (GO:0006997)3.27170747
83protein depolymerization (GO:0051261)3.21137350
84establishment of mitotic spindle localization (GO:0040001)3.21012418
85regulation of centrosome duplication (GO:0010824)3.20941082
86spliceosomal tri-snRNP complex assembly (GO:0000244)3.18750077
87protein localization to chromosome, centromeric region (GO:0071459)3.17736157
88metaphase plate congression (GO:0051310)3.14223169
89DNA synthesis involved in DNA repair (GO:0000731)3.13806597
90nuclear pore complex assembly (GO:0051292)3.12614344
91negative regulation of organelle assembly (GO:1902116)3.09602465
92phosphatidylethanolamine metabolic process (GO:0046337)3.08791665
93meiotic cell cycle process (GO:1903046)3.08565885
94sequestering of actin monomers (GO:0042989)3.06826045
95DNA replication initiation (GO:0006270)3.05912618
96ATP-dependent chromatin remodeling (GO:0043044)3.05778474
97positive regulation of chromosome segregation (GO:0051984)3.05249788
98protein K11-linked deubiquitination (GO:0035871)3.05209056
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.04359195
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.04359195
101positive regulation of mitotic sister chromatid separation (GO:1901970)3.04359195
102histone exchange (GO:0043486)3.01794322
103chromosome segregation (GO:0007059)3.01511387
104microtubule-based movement (GO:0007018)3.01501348
105regulation of spindle organization (GO:0090224)3.00800811
106mitotic G1 DNA damage checkpoint (GO:0031571)3.00046169
107gene silencing by RNA (GO:0031047)2.98647900
108intraciliary transport (GO:0042073)2.97210280
109peptidyl-lysine dimethylation (GO:0018027)2.96864012
110DNA strand elongation involved in DNA replication (GO:0006271)2.96589002
111RNA localization (GO:0006403)2.94819634
112regulation of RNA export from nucleus (GO:0046831)2.94729792
113DNA strand elongation (GO:0022616)2.93254121
114centrosome duplication (GO:0051298)2.93125130
115regulation of histone H3-K9 methylation (GO:0051570)2.92036533
116nucleoside diphosphate phosphorylation (GO:0006165)2.90921768
117lactate metabolic process (GO:0006089)2.90632207
118carnitine transport (GO:0015879)2.90291563
119amino-acid betaine transport (GO:0015838)2.90291563
120rRNA modification (GO:0000154)2.88702274
121cilium organization (GO:0044782)2.87682811
122synapsis (GO:0007129)2.87287048
123chromosome organization (GO:0051276)2.86499685
124polyol catabolic process (GO:0046174)2.85626791
125G1 DNA damage checkpoint (GO:0044783)2.84859219
126regulation of chromosome segregation (GO:0051983)2.84383010
127regulation of translational fidelity (GO:0006450)2.83828818
128protein localization to kinetochore (GO:0034501)2.82025700
129regulation of centriole replication (GO:0046599)2.81744749
130axoneme assembly (GO:0035082)2.80451557
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.79275224
132establishment of chromosome localization (GO:0051303)2.78390530
133kinetochore organization (GO:0051383)2.78307140
134V(D)J recombination (GO:0033151)2.76879965
135carnitine transmembrane transport (GO:1902603)2.75629739
136cilium assembly (GO:0042384)2.74469072
137interferon-gamma secretion (GO:0072643)2.70022595
138alditol metabolic process (GO:0019400)2.68045309
139cellular component assembly involved in morphogenesis (GO:0010927)2.67534424
140gene silencing (GO:0016458)2.64567331
141cilium morphogenesis (GO:0060271)2.63189842
142positive regulation of macrophage activation (GO:0043032)2.60051991
143GTP biosynthetic process (GO:0006183)2.59129217
144RNA destabilization (GO:0050779)2.57370426
145chromatin silencing (GO:0006342)2.56800228
146centriole assembly (GO:0098534)2.55524507
147nuclear pore organization (GO:0006999)2.54399747
148sperm motility (GO:0030317)13.7514440
149fusion of sperm to egg plasma membrane (GO:0007342)13.0880723
150acrosome reaction (GO:0007340)11.5846229
151cell wall macromolecule catabolic process (GO:0016998)11.4441902
152cell wall macromolecule metabolic process (GO:0044036)11.4441902
153sperm-egg recognition (GO:0035036)11.2341432
154acrosome assembly (GO:0001675)11.0282372
155multicellular organism reproduction (GO:0032504)10.5688731
156cilium or flagellum-dependent cell motility (GO:0001539)10.4644622
157binding of sperm to zona pellucida (GO:0007339)10.2920147
158cell-cell recognition (GO:0009988)10.0547713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.89358753
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.64784748
3EZH2_22144423_ChIP-Seq_EOC_Human4.53303657
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.02433642
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.83963053
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.73670922
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.13756079
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.94585898
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91890911
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.85431034
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.72363049
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59788669
13* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.50291442
14VDR_22108803_ChIP-Seq_LS180_Human2.36108133
15MYC_22102868_ChIP-Seq_BL_Human2.31078842
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.23403900
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.21600539
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.21297010
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.19588573
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.18464909
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16818121
22ZNF274_21170338_ChIP-Seq_K562_Hela2.05586892
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00548437
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2982954
25* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.99072421
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.96894084
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.94470611
28XRN2_22483619_ChIP-Seq_HELA_Human1.94245777
29* ELF1_20517297_ChIP-Seq_JURKAT_Human1.91726287
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90842385
31PKCTHETA_26484144_Chip-Seq_BREAST_Human1.87375246
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.83051427
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82892560
34KDM5A_27292631_Chip-Seq_BREAST_Human1.79328988
35ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78972201
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.77578066
37FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77443768
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77338413
39AR_21909140_ChIP-Seq_LNCAP_Human1.71998014
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70884436
41KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.69722550
42TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.67579613
43* SMC4_20622854_ChIP-Seq_HELA_Human1.67096833
44* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.66546760
45CIITA_25753668_ChIP-Seq_RAJI_Human1.66181306
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65800808
47* P68_20966046_ChIP-Seq_HELA_Human1.65666993
48VDR_21846776_ChIP-Seq_THP-1_Human1.64705687
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.62461403
50STAT1_17558387_ChIP-Seq_HELA_Human1.61416142
51LXR_22292898_ChIP-Seq_THP-1_Human1.60445512
52* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59136037
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58659388
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58221740
55SOX2_22085726_ChIP-Seq_NPCs_Mouse1.58076561
56GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54364221
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52728141
58* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49215220
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47851607
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45952005
61GATA3_21867929_ChIP-Seq_CD8_Mouse1.45154547
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44388798
63* NCOR1_26117541_ChIP-Seq_K562_Human1.44276157
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.43260745
65CBP_20019798_ChIP-Seq_JUKART_Human1.40645735
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40645735
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40040132
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38375007
69FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37872371
70TTF2_22483619_ChIP-Seq_HELA_Human1.36532883
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33915409
72* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33741072
73GABP_19822575_ChIP-Seq_HepG2_Human1.33113460
74LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32465950
75* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30778873
76REST_21632747_ChIP-Seq_MESCs_Mouse1.30282999
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.30192131
78KDM2B_26808549_Chip-Seq_REH_Human1.29809366
79RUNX1_27514584_Chip-Seq_MCF-7_Human1.29759510
80P53_21459846_ChIP-Seq_SAOS-2_Human1.28157811
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24674923
82KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24314438
83PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24020068
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24012165
85E2F1_17053090_ChIP-ChIP_MCF-7_Human1.22729370
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21922534
87DCP1A_22483619_ChIP-Seq_HELA_Human1.20570878
88GATA3_21867929_ChIP-Seq_TH1_Mouse1.19865438
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18585440
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18243529
91JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18197801
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17366497
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17366497
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.16747431
95* E2F1_20622854_ChIP-Seq_HELA_Human1.16510967
96CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16476562
97SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16100982
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15790000
99GF1_26923725_Chip-Seq_HPCs_Mouse1.15190329
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15033601
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14775897
102* BCL6_27268052_Chip-Seq_Bcells_Human1.14325938
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.14020792
104RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13949474
105KDM2B_26808549_Chip-Seq_DND41_Human1.12502579
106* TCF7_22412390_ChIP-Seq_EML_Mouse1.12465125
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12448877
108MAF_26560356_Chip-Seq_TH2_Human1.11945075
109BCOR_27268052_Chip-Seq_Bcells_Human1.11666009
110UTX_26944678_Chip-Seq_JUKART_Human1.11489930
111RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10815724
112CBX2_27304074_Chip-Seq_ESCs_Mouse1.10778392
113RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10632440
114FOXP1_21924763_ChIP-Seq_HESCs_Human1.10037387
115SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09846220
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09470128
117SPI1_26923725_Chip-Seq_HPCs_Mouse1.09316332
118* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08751279
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08692632
120CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08227056
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07960639
122RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07924712
123ERG_20517297_ChIP-Seq_VCAP_Human1.07180798
124YY1_21170310_ChIP-Seq_MESCs_Mouse1.06758910
125ETS1_20019798_ChIP-Seq_JURKAT_Human1.05988032
126YY1_22570637_ChIP-Seq_MALME-3M_Human1.05983498
127CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05950491
128RAC3_21632823_ChIP-Seq_H3396_Human1.05344903
129CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05033941
130EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04930269
131TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04082796
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03843319
133TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03711106
134KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03645550
135ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03126296
136ELK3_25401928_ChIP-Seq_HUVEC_Human1.02024977
137CTCF_21964334_Chip-Seq_Bcells_Human1.01618207
138* P300_27268052_Chip-Seq_Bcells_Human1.01297508
139MYC_27129775_Chip-Seq_CORNEA_Mouse1.00634711
140TP53_22127205_ChIP-Seq_IMR90_Human1.00491231
141SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99588059
142RARA_24833708_ChIP-Seq_LIVER_Mouse0.99058825
143NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98969278
144RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98879769
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98858363
146SA1_27219007_Chip-Seq_ERYTHROID_Human0.97477977
147CTCF_20526341_ChIP-Seq_ESCs_Human0.96988615
148MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96464915
149GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96092773
150* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95776132
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95759719
152ESET_19884257_ChIP-Seq_ESCs_Mouse0.95754924
153ERA_21632823_ChIP-Seq_H3396_Human0.95543977
154MAF_26560356_Chip-Seq_TH1_Human0.95287495
155EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94762750
156CRX_20693478_ChIP-Seq_RETINA_Mouse0.94546594
157TP63_22573176_ChIP-Seq_HFKS_Human0.94185673
158CHD1_26751641_Chip-Seq_LNCaP_Human0.93464128
159SOX11_22085726_ChIP-Seq_ESNs_Mouse0.93463506
160TET1_21451524_ChIP-Seq_MESCs_Mouse0.92697903
161NANOG_18555785_Chip-Seq_ESCs_Mouse0.92657931
162TAF15_26573619_Chip-Seq_HEK293_Human0.91515783
163NFYB_21822215_ChIP-Seq_K562_Human0.91472079
164SOX9_26525672_Chip-Seq_HEART_Mouse0.91201804
165PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91200424
166NANOG_21062744_ChIP-ChIP_HESCs_Human0.91080916
167GATA1_19941826_ChIP-Seq_K562_Human0.90887696
168CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90577306
169EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90568997
170CTCF_27219007_Chip-Seq_Bcells_Human0.89961155
171STAT3_18555785_ChIP-Seq_MESCs_Mouse0.89665871
172SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89465698
173RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88930762
174SOX2_21211035_ChIP-Seq_LN229_Human0.88720306
175NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88663048
176SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87014691
177CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87009883
178PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86911077
179FLI1_21867929_ChIP-Seq_CD8_Mouse0.86860503
180OCT4_18555785_Chip-Seq_ESCs_Mouse0.86011131
181PHF8_20622854_ChIP-Seq_HELA_Human0.85607460
182TBL1_22424771_ChIP-Seq_293T_Human0.85346320
183RNF2_27304074_Chip-Seq_NSC_Mouse0.85133387
184* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.84434895
185RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84111025
186LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83221746

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.94572952
2* MP0001929_abnormal_gametogenesis5.40880090
3MP0008877_abnormal_DNA_methylation4.41833478
4MP0002210_abnormal_sex_determination3.49622917
5* MP0002161_abnormal_fertility/fecundity3.26664010
6MP0001145_abnormal_male_reproductive2.97014170
7MP0002653_abnormal_ependyma_morphology2.83727454
8MP0005670_abnormal_white_adipose2.58938298
9MP0000653_abnormal_sex_gland2.56278634
10MP0002132_abnormal_respiratory_system2.11918180
11MP0003718_maternal_effect2.05556037
12MP0000678_abnormal_parathyroid_gland2.05228313
13MP0005410_abnormal_fertilization15.9785032
14MP0002249_abnormal_larynx_morphology1.95690874
15MP0005451_abnormal_body_composition1.90828027
16MP0000566_synostosis1.83930960
17MP0005623_abnormal_meninges_morphology1.83406159
18MP0008932_abnormal_embryonic_tissue1.80035965
19MP0002160_abnormal_reproductive_system1.76108983
20MP0002822_catalepsy1.71774783
21MP0005499_abnormal_olfactory_system1.69490712
22MP0005394_taste/olfaction_phenotype1.69490712
23MP0001348_abnormal_lacrimal_gland1.66983914
24MP0008789_abnormal_olfactory_epithelium1.50954186
25MP0003315_abnormal_perineum_morphology1.50720159
26MP0003705_abnormal_hypodermis_morpholog1.50522214
27MP0004233_abnormal_muscle_weight1.43855397
28MP0009697_abnormal_copulation1.41434182
29MP0003646_muscle_fatigue1.39535433
30MP0005076_abnormal_cell_differentiation1.39469406
31MP0002282_abnormal_trachea_morphology1.36095889
32MP0009053_abnormal_anal_canal1.28432949
33MP0002396_abnormal_hematopoietic_system1.24099471
34MP0008058_abnormal_DNA_repair1.21201693
35MP0003656_abnormal_erythrocyte_physiolo1.18338335
36MP0010094_abnormal_chromosome_stability1.10879197
37MP0002877_abnormal_melanocyte_morpholog1.08630710
38MP0005409_darkened_coat_color1.05902724
39MP0002009_preneoplasia0.99650969
40MP0001765_abnormal_ion_homeostasis0.98042836
41MP0008995_early_reproductive_senescence0.96538709
42MP0003111_abnormal_nucleus_morphology0.95230300
43MP0005083_abnormal_biliary_tract0.93829109
44MP0009046_muscle_twitch0.93065495
45MP0002086_abnormal_extraembryonic_tissu0.93049230
46MP0005395_other_phenotype0.91787688
47MP0008057_abnormal_DNA_replication0.91321682
48MP0001984_abnormal_olfaction0.90611723
49MP0010030_abnormal_orbit_morphology0.90459473
50MP0005389_reproductive_system_phenotype0.89714765
51MP0000569_abnormal_digit_pigmentation0.88647530
52MP0002019_abnormal_tumor_incidence0.88427714
53MP0000703_abnormal_thymus_morphology0.87868050
54MP0005647_abnormal_sex_gland0.87445817
55MP0003385_abnormal_body_wall0.86500209
56MP0003878_abnormal_ear_physiology0.85892339
57MP0005377_hearing/vestibular/ear_phenot0.85892339
58MP0003115_abnormal_respiratory_system0.83102174
59MP0005248_abnormal_Harderian_gland0.81939067
60MP0005408_hypopigmentation0.81141999
61MP0002234_abnormal_pharynx_morphology0.73130284
62MP0001270_distended_abdomen0.72201562
63MP0000015_abnormal_ear_pigmentation0.70664817
64MP0003935_abnormal_craniofacial_develop0.69614547
65MP0000681_abnormal_thyroid_gland0.67433630
66MP0001879_abnormal_lymphatic_vessel0.67080652
67MP0001293_anophthalmia0.66154963
68MP0001529_abnormal_vocalization0.65149353
69MP0006292_abnormal_olfactory_placode0.64958409
70MP0008007_abnormal_cellular_replicative0.64565372
71MP0005621_abnormal_cell_physiology0.62951340
72MP0000428_abnormal_craniofacial_morphol0.62278216
73MP0002116_abnormal_craniofacial_bone0.61951857
74MP0000467_abnormal_esophagus_morphology0.61905290
75MP0000358_abnormal_cell_content/0.60455464
76MP0003937_abnormal_limbs/digits/tail_de0.60226490
77MP0001730_embryonic_growth_arrest0.60097294
78MP0003763_abnormal_thymus_physiology0.59752035
79MP0000049_abnormal_middle_ear0.59121729
80MP0009278_abnormal_bone_marrow0.56371667
81MP0003786_premature_aging0.55187136
82MP0003077_abnormal_cell_cycle0.55001505
83MP0003699_abnormal_female_reproductive0.53732843
84MP0005397_hematopoietic_system_phenotyp0.52572736
85MP0001545_abnormal_hematopoietic_system0.52572736
86MP0005666_abnormal_adipose_tissue0.52070697
87MP0004133_heterotaxia0.50214835
88MP0010307_abnormal_tumor_latency0.49999299
89MP0003950_abnormal_plasma_membrane0.49207043
90MP0002269_muscular_atrophy0.47413275
91MP0000534_abnormal_ureter_morphology0.43740623
92MP0005636_abnormal_mineral_homeostasis0.43653336
93MP0002084_abnormal_developmental_patter0.43356049
94MP0004036_abnormal_muscle_relaxation0.43248378
95MP0001324_abnormal_eye_pigmentation0.42789168
96MP0003861_abnormal_nervous_system0.42437618
97MP0003329_amyloid_beta_deposits0.42032774
98MP0003787_abnormal_imprinting0.41978026
99MP0002928_abnormal_bile_duct0.40317053
100MP0003011_delayed_dark_adaptation0.39282810
101MP0005253_abnormal_eye_physiology0.38566064
102MP0005391_vision/eye_phenotype0.38133081
103MP0001672_abnormal_embryogenesis/_devel0.37358985
104MP0005380_embryogenesis_phenotype0.37358985
105MP0003942_abnormal_urinary_system0.34605993
106MP0001697_abnormal_embryo_size0.34484850
107MP0001119_abnormal_female_reproductive0.34256276
108MP0002736_abnormal_nociception_after0.34204900
109MP0004811_abnormal_neuron_physiology0.33350472
110MP0002152_abnormal_brain_morphology0.33126077
111MP0004808_abnormal_hematopoietic_stem0.32861751
112MP0000313_abnormal_cell_death0.32474500
113MP0008961_abnormal_basal_metabolism0.31615869
114MP0004957_abnormal_blastocyst_morpholog0.31265118
115MP0001849_ear_inflammation0.31254497
116MP0002092_abnormal_eye_morphology0.30540701
117MP0009115_abnormal_fat_cell0.29579498
118MP0002085_abnormal_embryonic_tissue0.29499272
119MP0003879_abnormal_hair_cell0.29100995
120MP0003984_embryonic_growth_retardation0.28166398
121MP0003693_abnormal_embryo_hatching0.27654462
122MP0005551_abnormal_eye_electrophysiolog0.27298701
123MP0001727_abnormal_embryo_implantation0.26793970
124MP0004197_abnormal_fetal_growth/weight/0.26734179
125MP0001764_abnormal_homeostasis0.26192604
126MP0002088_abnormal_embryonic_growth/wei0.25905108
127* MP0002080_prenatal_lethality0.25346051
128MP0002169_no_abnormal_phenotype0.24175816
129MP0002873_normal_phenotype0.23927017
130MP0009672_abnormal_birth_weight0.23919678
131MP0006036_abnormal_mitochondrial_physio0.21615524
132MP0002102_abnormal_ear_morphology0.20342995
133MP0003633_abnormal_nervous_system0.20142860
134MP0003631_nervous_system_phenotype0.19792261
135MP0002971_abnormal_brown_adipose0.19492083
136MP0004742_abnormal_vestibular_system0.19225083
137MP0000751_myopathy0.18889334
138MP0003948_abnormal_gas_homeostasis0.18382377
139MP0000350_abnormal_cell_proliferation0.17320883
140MP0000001_mammalian_phenotype0.16770054
141MP0004145_abnormal_muscle_electrophysio0.16751815
142MP0000537_abnormal_urethra_morphology0.16453620
143MP0000432_abnormal_head_morphology0.16438781
144MP0009703_decreased_birth_body0.16384783
145MP0008770_decreased_survivor_rate0.16293524

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.17956994
2Abnormal respiratory epithelium morphology (HP:0012253)9.02374224
3Abnormal respiratory motile cilium morphology (HP:0005938)9.02374224
4Rhinitis (HP:0012384)7.50576588
5Abnormal ciliary motility (HP:0012262)7.26276489
6Chronic bronchitis (HP:0004469)7.10054042
7Infertility (HP:0000789)6.80073146
8Nasal polyposis (HP:0100582)6.28449050
9Abnormality of the nasal mucosa (HP:0000433)5.15613961
10Male infertility (HP:0003251)4.67296551
11Bronchitis (HP:0012387)4.58186936
12Bronchiectasis (HP:0002110)4.44408203
13Nephronophthisis (HP:0000090)4.41481714
14Abnormal spermatogenesis (HP:0008669)3.53506073
15Recurrent otitis media (HP:0000403)3.33322985
16Abnormality of the renal medulla (HP:0100957)3.32283045
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.23172156
18Recurrent sinusitis (HP:0011108)3.22645172
19Severe visual impairment (HP:0001141)3.16649731
20Impulsivity (HP:0100710)2.97314965
21Chromsome breakage (HP:0040012)2.96787278
22Tubulointerstitial nephritis (HP:0001970)2.93400520
23Recurrent bronchitis (HP:0002837)2.90275532
24Atelectasis (HP:0100750)2.85353890
25Chronic hepatic failure (HP:0100626)2.76756324
26Tubular atrophy (HP:0000092)2.66349959
27Molar tooth sign on MRI (HP:0002419)2.62729294
28Abnormality of midbrain morphology (HP:0002418)2.62729294
29Occipital encephalocele (HP:0002085)2.61273292
30Gonadotropin excess (HP:0000837)2.58070765
31Flattened epiphyses (HP:0003071)2.54515180
32Tubulointerstitial abnormality (HP:0001969)2.43450879
33Resting tremor (HP:0002322)2.37976645
34Renovascular hypertension (HP:0100817)2.35622841
35Duodenal stenosis (HP:0100867)2.31193727
36Small intestinal stenosis (HP:0012848)2.31193727
37Hand muscle atrophy (HP:0009130)2.30119098
38Facial hemangioma (HP:0000329)2.29633091
39Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.26086617
40Aplasia/Hypoplasia of the earlobes (HP:0009906)2.26034898
41Abnormality of the lower motor neuron (HP:0002366)2.25131345
42Abnormal gallbladder physiology (HP:0012438)2.21582164
43Cholecystitis (HP:0001082)2.21582164
44Azoospermia (HP:0000027)2.19655228
45Short nail (HP:0001799)2.18733991
46Medial flaring of the eyebrow (HP:0010747)2.18642645
4711 pairs of ribs (HP:0000878)2.18107809
48Increased nuchal translucency (HP:0010880)2.15474308
49Hyperacusis (HP:0010780)2.11860137
50High anterior hairline (HP:0009890)2.07254237
51Heterotopia (HP:0002282)2.06094771
52Hypoparathyroidism (HP:0000829)2.03660818
53Sloping forehead (HP:0000340)2.02421976
54Abnormality of DNA repair (HP:0003254)2.02311328
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.01537760
56Abnormality of the ileum (HP:0001549)2.01144379
57Self-mutilation (HP:0000742)2.00688402
58Absent/shortened dynein arms (HP:0200106)13.1387402
59Dynein arm defect of respiratory motile cilia (HP:0012255)13.1387402
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0407803
61Dyschromatopsia (HP:0007641)1.98061870
62Meckel diverticulum (HP:0002245)1.97350543
63Abnormality of the carotid arteries (HP:0005344)1.96245383
64Spastic tetraparesis (HP:0001285)1.94104856
65Reticulocytosis (HP:0001923)1.94074605
66Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92338606
67Postaxial foot polydactyly (HP:0001830)1.91653389
68Sandal gap (HP:0001852)1.91091065
69Tubulointerstitial fibrosis (HP:0005576)1.89441339
70Myelodysplasia (HP:0002863)1.89427733
71Short ribs (HP:0000773)1.86067157
72Bony spicule pigmentary retinopathy (HP:0007737)1.84626288
73Obsessive-compulsive behavior (HP:0000722)1.83472466
74Upper limb amyotrophy (HP:0009129)1.82689110
75Distal upper limb amyotrophy (HP:0007149)1.82689110
76Amyotrophic lateral sclerosis (HP:0007354)1.82491623
77Choroideremia (HP:0001139)1.81020706
78Stage 5 chronic kidney disease (HP:0003774)1.80696591
79Abnormality of the preputium (HP:0100587)1.78061465
80Upper limb muscle weakness (HP:0003484)1.77720811
81Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.73419302
82Fibular hypoplasia (HP:0003038)1.72993088
83Abnormal drinking behavior (HP:0030082)1.72102807
84Polydipsia (HP:0001959)1.72102807
85Congenital hepatic fibrosis (HP:0002612)1.71672567
86Abnormality of reticulocytes (HP:0004312)1.71004362
87Abnormality of chromosome segregation (HP:0002916)1.69701445
88Flared metaphyses (HP:0003015)1.69666060
89Patellar dislocation (HP:0002999)1.67284106
90Cone-rod dystrophy (HP:0000548)1.66912200
91Decreased central vision (HP:0007663)1.66629826
92Long eyelashes (HP:0000527)1.65882605
93Bowel incontinence (HP:0002607)1.65742069
94Abnormality of the duodenum (HP:0002246)1.65556760
95Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65458399
96Missing ribs (HP:0000921)1.65120890
97Abnormal biliary tract physiology (HP:0012439)1.64492051
98Bile duct proliferation (HP:0001408)1.64492051
99Broad face (HP:0000283)1.64343471
100Squamous cell carcinoma (HP:0002860)1.63850891
101Bell-shaped thorax (HP:0001591)1.63811075
102Polycystic kidney dysplasia (HP:0000113)1.63621139
103Oculomotor apraxia (HP:0000657)1.63278038
104Abnormality of the renal cortex (HP:0011035)1.61197429
105Abnormality of dentin (HP:0010299)1.61071950
106Attenuation of retinal blood vessels (HP:0007843)1.60764090
107Ectopic kidney (HP:0000086)1.60104371
108Abnormality of the aortic arch (HP:0012303)1.59727637
109Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59588704
110Short 4th metacarpal (HP:0010044)1.59588704
111Absent frontal sinuses (HP:0002688)1.59252346
112Aplasia/Hypoplasia of the thymus (HP:0010515)1.58623879
113Abnormality of chromosome stability (HP:0003220)1.57758357
114Overlapping toe (HP:0001845)1.57041076
115Deep palmar crease (HP:0006191)1.55641527
116Intellectual disability, moderate (HP:0002342)1.55188285
117Progressive hearing impairment (HP:0001730)1.52945587
118Abnormality of the dental root (HP:0006486)1.52514313
119Taurodontia (HP:0000679)1.52514313
120Abnormality of permanent molar morphology (HP:0011071)1.52514313
121Trigonocephaly (HP:0000243)1.51995850
122Absent epiphyses (HP:0010577)1.51494997
123Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.51494997
124Abnormal large intestine physiology (HP:0012700)1.51489202
125Abnormality of renal excretion (HP:0011036)1.50360850
126Hyperkalemia (HP:0002153)1.50271992
127Hyperthyroidism (HP:0000836)1.50157597
128Facial cleft (HP:0002006)1.48914558
129Renal dysplasia (HP:0000110)1.48783368
130Supernumerary spleens (HP:0009799)1.46479822
131Postaxial hand polydactyly (HP:0001162)1.45835040
132Broad distal phalanx of finger (HP:0009836)1.44918459
133Deformed sella turcica (HP:0002681)1.44899197
134Cystic liver disease (HP:0006706)1.42949666
135Hemorrhage of the eye (HP:0011885)1.42786269
136Abnormality of molar morphology (HP:0011070)1.39296432
137Abnormality of molar (HP:0011077)1.39296432
138Abnormality of the dental pulp (HP:0006479)1.39101295
139Hemiparesis (HP:0001269)1.38926456
140Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.37810839
141Microglossia (HP:0000171)1.35601403
142J-shaped sella turcica (HP:0002680)1.33857785
143Truncal obesity (HP:0001956)1.32609514
144Impaired proprioception (HP:0010831)1.31193778
145Short thorax (HP:0010306)1.30237050
146Abnormality of ocular smooth pursuit (HP:0000617)1.28002557
147Neurofibrillary tangles (HP:0002185)1.27835288
148Bundle branch block (HP:0011710)1.26831289
149Asymmetric septal hypertrophy (HP:0001670)1.25840239
150Decreased electroretinogram (ERG) amplitude (HP:0000654)1.25482566
151Aplasia/Hypoplasia of the lens (HP:0008063)1.25372375
152Congenital malformation of the right heart (HP:0011723)1.24429206
153Double outlet right ventricle (HP:0001719)1.24429206
154Abnormal urine output (HP:0012590)1.23943338
155Pancreatic fibrosis (HP:0100732)1.22992128
156Chronic sinusitis (HP:0011109)1.22364179
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.19289591
158Median cleft lip (HP:0000161)1.16954328
159Short femoral neck (HP:0100864)1.15708624
160Nephropathy (HP:0000112)1.14973215
161Cerebral inclusion bodies (HP:0100314)1.14190330
162Cerebellar dysplasia (HP:0007033)1.13298279
163Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.11779568
164Pachygyria (HP:0001302)1.10106552
165Easy fatigability (HP:0003388)1.09812582
166Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.09745792

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.97927599
2PDK37.97927599
3TESK16.05548981
4PDK25.11746398
5PRKD35.06370851
6ICK4.48173867
7TRIB32.95768426
8PNCK2.65227718
9PTK2B2.38099433
10BRD42.30331649
11SMG12.27899920
12WNK42.13308635
13NEK21.97391390
14STK391.95887807
15CDK71.92320943
16STK381.77118527
17DYRK1B1.57583409
18EIF2AK11.46495487
19SRPK11.38382818
20RPS6KB21.32334693
21PBK1.31626298
22MST1R1.29634821
23SCYL21.28382128
24KSR21.25593408
25NEK11.24621013
26MAP3K81.23489045
27CDK81.15887723
28DDR21.14583533
29SIK21.12470528
30TYRO31.07845224
31PKN21.07695086
32PDK11.07656166
33WNK10.98031478
34EEF2K0.94030328
35DYRK30.92675380
36TTK0.92442994
37PASK0.91622521
38LATS10.91048047
39RPS6KA40.87417860
40CDK30.82142802
41MAPK150.81952149
42CDC70.81531881
43CAMK1G0.79004463
44CCNB10.77088981
45CDK90.76960432
46RAF10.75779747
47PLK20.75493816
48TSSK60.75150215
49ZAK0.72282065
50TLK10.70451446
51CHEK20.69868877
52STK30.69187950
53WEE10.65970561
54TESK20.64926710
55LATS20.61673710
56MAPK110.61282954
57MAP2K20.61274105
58CHEK10.60293920
59NME20.59727433
60PDPK10.59682408
61MET0.57940168
62AKT20.56737015
63CDK120.53210723
64RET0.49813650
65STK40.49769311
66KSR10.49602662
67MAP2K60.49423706
68ATR0.49123796
69MAP4K20.48378101
70RPS6KA50.48350352
71INSRR0.48216681
72VRK20.48066076
73NTRK20.47219098
74IRAK10.47177776
75PAK10.46649587
76RIPK40.45975623
77ATM0.43789253
78MTOR0.41804256
79MELK0.40921648
80IRAK30.40605246
81SIK10.39270321
82MAP3K130.39163837
83MAP3K100.38429739
84PINK10.37745335
85AKT10.37230210
86PAK40.36630182
87MKNK10.36407239
88PLK10.35827069
89PAK20.35730582
90LMTK20.34868238
91STK38L0.34694110
92VRK10.34331139
93MAPKAPK30.34140882
94RPS6KA20.32739607
95RPS6KC10.32448932
96RPS6KL10.32448932
97LRRK20.31664122
98PRKCG0.30913544
99PLK40.30848447
100MARK20.27751296
101BRSK10.26214426
102BRSK20.24408254
103NEK60.24125455
104BUB10.21480980
105CAMKK10.21291039
106MUSK0.21003942
107RPS6KB10.20691177
108STK100.20645974
109PRKAA10.20390971
110CDK150.17688701
111CDK20.17342551
112IRAK20.16874216
113CSNK1D0.15490951
114CDK180.14842822
115CDK11A0.14549834
116MAPKAPK50.13748432
117CDK60.12975725
118CDK40.12612879
119* CDK10.10266380
120AURKA0.10125952
121PAK60.10107282
122BRAF0.10025504
123RPS6KA10.09822421
124PRKCZ0.09693898
125* GSK3B0.09423486
126CSNK2A10.08740204
127CDK140.08496127
128PRKDC0.07540186
129MAP3K40.07293909
130MAPK80.06619641
131CSNK2A20.06578569
132PRKCQ0.06345576
133MARK30.05722129
134AURKB0.05153737
135PIM10.05037887
136STK110.04030366
137CSF1R0.03360599
138CLK10.03299769
139PRKCB0.02884065
140MAPK10.01695914
141RPS6KA30.00984496
142PRKG10.00924450
143CSNK1E0.00207438
144WNK3-0.0262880
145PRKG2-0.0253231
146PDGFRB-0.0243936
147EGFR-0.0225124
148MAPK10-0.0170763
149MAPK14-0.0126753
150PRKACG-0.0085482
151PRKACB-0.0045442

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.58596567
2Fatty acid biosynthesis_Homo sapiens_hsa000614.26064739
3Pyruvate metabolism_Homo sapiens_hsa006203.35228346
4Vitamin B6 metabolism_Homo sapiens_hsa007503.24597413
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.75712141
6Glucagon signaling pathway_Homo sapiens_hsa049222.68770565
7Linoleic acid metabolism_Homo sapiens_hsa005912.65855017
8Basal transcription factors_Homo sapiens_hsa030222.48345568
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.47019329
10Nucleotide excision repair_Homo sapiens_hsa034202.46206251
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.44250452
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.34167597
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32213603
14Propanoate metabolism_Homo sapiens_hsa006402.28844466
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26307907
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.13284417
17Oocyte meiosis_Homo sapiens_hsa041142.10645751
18Mismatch repair_Homo sapiens_hsa034302.10063081
19Selenocompound metabolism_Homo sapiens_hsa004502.01419367
20Dorso-ventral axis formation_Homo sapiens_hsa043201.96330339
21Non-homologous end-joining_Homo sapiens_hsa034501.93895251
22Fanconi anemia pathway_Homo sapiens_hsa034601.92348819
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84495907
24Glycerolipid metabolism_Homo sapiens_hsa005611.75812685
25mRNA surveillance pathway_Homo sapiens_hsa030151.72578955
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.69302316
27Fructose and mannose metabolism_Homo sapiens_hsa000511.65544199
28Pentose phosphate pathway_Homo sapiens_hsa000301.62680012
29Non-small cell lung cancer_Homo sapiens_hsa052231.61965409
30Amphetamine addiction_Homo sapiens_hsa050311.60931797
31Chronic myeloid leukemia_Homo sapiens_hsa052201.60755620
32Acute myeloid leukemia_Homo sapiens_hsa052211.57837715
33RNA transport_Homo sapiens_hsa030131.57027308
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.54894015
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53452547
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.47816840
37One carbon pool by folate_Homo sapiens_hsa006701.45727543
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43771307
39PPAR signaling pathway_Homo sapiens_hsa033201.42386773
40Olfactory transduction_Homo sapiens_hsa047401.36308170
41Mineral absorption_Homo sapiens_hsa049781.34241167
42Antigen processing and presentation_Homo sapiens_hsa046121.33135927
43Thyroid cancer_Homo sapiens_hsa052161.29766601
44Carbon metabolism_Homo sapiens_hsa012001.26430096
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.24215514
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.23584907
47Cardiac muscle contraction_Homo sapiens_hsa042601.21358939
48Endometrial cancer_Homo sapiens_hsa052131.19368937
49Pancreatic cancer_Homo sapiens_hsa052121.19253570
50Ether lipid metabolism_Homo sapiens_hsa005651.17423330
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15227950
52Prostate cancer_Homo sapiens_hsa052151.12422537
53Renin secretion_Homo sapiens_hsa049241.08758107
54Purine metabolism_Homo sapiens_hsa002301.08622776
55Fat digestion and absorption_Homo sapiens_hsa049751.08190856
56Huntingtons disease_Homo sapiens_hsa050161.07338694
57Hedgehog signaling pathway_Homo sapiens_hsa043401.06304548
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.04447893
59MicroRNAs in cancer_Homo sapiens_hsa052061.03779968
60B cell receptor signaling pathway_Homo sapiens_hsa046620.99134963
61Gap junction_Homo sapiens_hsa045400.98675738
62Long-term potentiation_Homo sapiens_hsa047200.97551597
63Lysine degradation_Homo sapiens_hsa003100.97545197
64Bladder cancer_Homo sapiens_hsa052190.97500911
65Notch signaling pathway_Homo sapiens_hsa043300.96995891
66Fatty acid metabolism_Homo sapiens_hsa012120.95960709
67Apoptosis_Homo sapiens_hsa042100.95394627
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94382499
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93984543
70Estrogen signaling pathway_Homo sapiens_hsa049150.93390725
71Biosynthesis of amino acids_Homo sapiens_hsa012300.90197587
72Colorectal cancer_Homo sapiens_hsa052100.87313702
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85946955
74HTLV-I infection_Homo sapiens_hsa051660.85309982
75mTOR signaling pathway_Homo sapiens_hsa041500.84380301
76Choline metabolism in cancer_Homo sapiens_hsa052310.83317484
77Insulin secretion_Homo sapiens_hsa049110.82870622
78Fatty acid degradation_Homo sapiens_hsa000710.82482545
79Glioma_Homo sapiens_hsa052140.81800274
80ErbB signaling pathway_Homo sapiens_hsa040120.81733125
81Small cell lung cancer_Homo sapiens_hsa052220.80098029
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.79584739
83Hepatitis B_Homo sapiens_hsa051610.76566311
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73788509
85N-Glycan biosynthesis_Homo sapiens_hsa005100.73150798
86Thyroid hormone synthesis_Homo sapiens_hsa049180.72535913
87Adherens junction_Homo sapiens_hsa045200.70620710
88Glutathione metabolism_Homo sapiens_hsa004800.67193057
89Herpes simplex infection_Homo sapiens_hsa051680.66924892
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.66699614
91Prolactin signaling pathway_Homo sapiens_hsa049170.66063709
92Collecting duct acid secretion_Homo sapiens_hsa049660.65388164
93Phenylalanine metabolism_Homo sapiens_hsa003600.64703569
94Butanoate metabolism_Homo sapiens_hsa006500.63183506
95Legionellosis_Homo sapiens_hsa051340.62273401
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62053888
97DNA replication_Homo sapiens_hsa030300.61488559
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61213098
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60345616
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59228734
101p53 signaling pathway_Homo sapiens_hsa041150.58072829
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57560955
103Cell cycle_Homo sapiens_hsa041100.57233957
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55723080
105Renal cell carcinoma_Homo sapiens_hsa052110.55708622
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55190530
107Systemic lupus erythematosus_Homo sapiens_hsa053220.54896624
108Calcium signaling pathway_Homo sapiens_hsa040200.54287689
109Influenza A_Homo sapiens_hsa051640.53664900
110Endocytosis_Homo sapiens_hsa041440.53218886
111Arachidonic acid metabolism_Homo sapiens_hsa005900.53044598
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52169690
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.51830163
114Synaptic vesicle cycle_Homo sapiens_hsa047210.49636699
115AMPK signaling pathway_Homo sapiens_hsa041520.49285178
116Bile secretion_Homo sapiens_hsa049760.49248144
117Salivary secretion_Homo sapiens_hsa049700.49085042
118VEGF signaling pathway_Homo sapiens_hsa043700.48873345
119RNA degradation_Homo sapiens_hsa030180.48778133
120Inositol phosphate metabolism_Homo sapiens_hsa005620.48598072
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46398159
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45840574
123Pancreatic secretion_Homo sapiens_hsa049720.45478307
124Renin-angiotensin system_Homo sapiens_hsa046140.45442298
125Pyrimidine metabolism_Homo sapiens_hsa002400.44426598
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43525716
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43311895
128Focal adhesion_Homo sapiens_hsa045100.42757628
129T cell receptor signaling pathway_Homo sapiens_hsa046600.42604713
130Gastric acid secretion_Homo sapiens_hsa049710.41827289
131Taste transduction_Homo sapiens_hsa047420.40352087
132Hippo signaling pathway_Homo sapiens_hsa043900.39535730
133RNA polymerase_Homo sapiens_hsa030200.39445101
134Alcoholism_Homo sapiens_hsa050340.38717235
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.38636501
136Protein digestion and absorption_Homo sapiens_hsa049740.38352726
137Circadian entrainment_Homo sapiens_hsa047130.38283653
138Spliceosome_Homo sapiens_hsa030400.37749433
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36966939
140ABC transporters_Homo sapiens_hsa020100.36491650
141cAMP signaling pathway_Homo sapiens_hsa040240.36044128
142Melanoma_Homo sapiens_hsa052180.34554200
143Insulin signaling pathway_Homo sapiens_hsa049100.34398713
144Basal cell carcinoma_Homo sapiens_hsa052170.33712653
145Chemical carcinogenesis_Homo sapiens_hsa052040.33262284
146Type II diabetes mellitus_Homo sapiens_hsa049300.32135977
147Pathways in cancer_Homo sapiens_hsa052000.31214193
148Wnt signaling pathway_Homo sapiens_hsa043100.28540051
149Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28104764
150Viral carcinogenesis_Homo sapiens_hsa052030.27301305
151Base excision repair_Homo sapiens_hsa034100.26677012
152Homologous recombination_Homo sapiens_hsa034400.26148783
153Cocaine addiction_Homo sapiens_hsa050300.22092581
154HIF-1 signaling pathway_Homo sapiens_hsa040660.20867300
155Metabolic pathways_Homo sapiens_hsa011000.20398676
156Epstein-Barr virus infection_Homo sapiens_hsa051690.19741420

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