ODF2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)7.00037075
2axonemal dynein complex assembly (GO:0070286)6.38182534
3cilium movement (GO:0003341)6.37432987
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.92779407
5epithelial cilium movement (GO:0003351)5.45434561
6axoneme assembly (GO:0035082)5.44329496
7kinetochore organization (GO:0051383)4.89767160
8centriole replication (GO:0007099)4.71958711
9mitotic sister chromatid cohesion (GO:0007064)4.70589326
10motile cilium assembly (GO:0044458)4.68607028
11regulation of DNA endoreduplication (GO:0032875)4.67043892
12intraciliary transport (GO:0042073)4.38463756
13neural tube formation (GO:0001841)4.30205873
14polyketide metabolic process (GO:0030638)4.25234317
15doxorubicin metabolic process (GO:0044598)4.25234317
16daunorubicin metabolic process (GO:0044597)4.25234317
17centriole assembly (GO:0098534)4.17644363
18negative regulation of DNA-dependent DNA replication (GO:2000104)4.11833791
19establishment of protein localization to Golgi (GO:0072600)4.11066887
20kinetochore assembly (GO:0051382)4.07584231
21CENP-A containing nucleosome assembly (GO:0034080)4.03805538
22behavioral response to nicotine (GO:0035095)4.02516311
23indole-containing compound catabolic process (GO:0042436)3.94655997
24indolalkylamine catabolic process (GO:0046218)3.94655997
25tryptophan catabolic process (GO:0006569)3.94655997
26chromatin remodeling at centromere (GO:0031055)3.94517404
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.86780197
28indolalkylamine metabolic process (GO:0006586)3.84679587
29regulation of centriole replication (GO:0046599)3.84622476
30nuclear pore complex assembly (GO:0051292)3.82900216
31regulation of translation, ncRNA-mediated (GO:0045974)3.82857230
32negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.82857230
33negative regulation of translation, ncRNA-mediated (GO:0040033)3.82857230
34kynurenine metabolic process (GO:0070189)3.82493433
35pyrimidine dimer repair (GO:0006290)3.80609338
36nuclear pore organization (GO:0006999)3.80290745
37replicative senescence (GO:0090399)3.68571169
38metaphase plate congression (GO:0051310)3.63159567
39meiotic chromosome segregation (GO:0045132)3.60704251
40intra-S DNA damage checkpoint (GO:0031573)3.59820995
41regulation of pigment cell differentiation (GO:0050932)3.59138055
42histone exchange (GO:0043486)3.58937017
43histone H3-K9 methylation (GO:0051567)3.57008320
44male meiosis (GO:0007140)3.54010042
45ventricular system development (GO:0021591)3.52802977
46tryptophan metabolic process (GO:0006568)3.47249820
47interkinetic nuclear migration (GO:0022027)3.45838673
48sister chromatid segregation (GO:0000819)3.43442348
49mitotic metaphase plate congression (GO:0007080)3.42250370
50positive regulation of developmental pigmentation (GO:0048087)3.42030574
51detection of light stimulus involved in visual perception (GO:0050908)3.41337935
52detection of light stimulus involved in sensory perception (GO:0050962)3.41337935
53DNA topological change (GO:0006265)3.36467448
54DNA replication-independent nucleosome assembly (GO:0006336)3.34476491
55DNA replication-independent nucleosome organization (GO:0034724)3.34476491
56cilium organization (GO:0044782)3.31757496
57establishment of chromosome localization (GO:0051303)3.31461915
58tachykinin receptor signaling pathway (GO:0007217)3.30201351
59histone H3-K9 modification (GO:0061647)3.24944596
60meiotic cell cycle (GO:0051321)3.23592523
61monoubiquitinated protein deubiquitination (GO:0035520)3.21467627
62cilium assembly (GO:0042384)3.21400654
63piRNA metabolic process (GO:0034587)3.20132569
64regulation of centrosome cycle (GO:0046605)3.19911098
65regulation of establishment of cell polarity (GO:2000114)3.18233056
66cornea development in camera-type eye (GO:0061303)3.16226994
67regulation of centrosome duplication (GO:0010824)3.15962049
68regulation of nuclear cell cycle DNA replication (GO:0033262)3.15644837
69L-fucose catabolic process (GO:0042355)3.14890042
70fucose catabolic process (GO:0019317)3.14890042
71L-fucose metabolic process (GO:0042354)3.14890042
72snRNA transcription (GO:0009301)3.13668366
73left/right axis specification (GO:0070986)3.11808995
74DNA ligation (GO:0006266)3.10985633
75DNA double-strand break processing (GO:0000729)3.09761515
76protein K6-linked ubiquitination (GO:0085020)3.09259312
77histone H3-K4 trimethylation (GO:0080182)3.08362196
78microtubule depolymerization (GO:0007019)3.08260525
79regulation of development, heterochronic (GO:0040034)3.05113631
80protein targeting to Golgi (GO:0000042)3.04835506
81serotonin metabolic process (GO:0042428)3.04817914
82signal peptide processing (GO:0006465)3.04723306
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.04245936
84protein localization to cilium (GO:0061512)3.02747174
85cilium morphogenesis (GO:0060271)3.01894194
86indole-containing compound metabolic process (GO:0042430)3.01363777
87pore complex assembly (GO:0046931)3.01316053
88regulation of action potential (GO:0098900)3.01087043
89DNA synthesis involved in DNA repair (GO:0000731)3.00742695
90cytoplasmic mRNA processing body assembly (GO:0033962)3.00065974
91peptidyl-lysine trimethylation (GO:0018023)2.99593483
92regulation of gene silencing by RNA (GO:0060966)2.99037672
93regulation of posttranscriptional gene silencing (GO:0060147)2.99037672
94regulation of gene silencing by miRNA (GO:0060964)2.99037672
95nonmotile primary cilium assembly (GO:0035058)2.97638809
96regulation of hippo signaling (GO:0035330)2.96801193
97response to X-ray (GO:0010165)2.96675293
98male meiosis I (GO:0007141)2.96057814
99negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.96040280
100centrosome organization (GO:0051297)2.95494292
101cerebellar Purkinje cell differentiation (GO:0021702)2.95447221
102regulation of establishment or maintenance of cell polarity (GO:0032878)2.95016447
103regulation of cilium movement (GO:0003352)2.94514790
104sister chromatid cohesion (GO:0007062)2.93652373
105appendage development (GO:0048736)2.90888123
106limb development (GO:0060173)2.90888123
107regulation of mitotic spindle checkpoint (GO:1903504)2.90706986
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90706986
109gamma-aminobutyric acid transport (GO:0015812)2.88674134
110phospholipid translocation (GO:0045332)2.88502305
111lipid translocation (GO:0034204)2.88502305
112cellular component assembly involved in morphogenesis (GO:0010927)2.87650991
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87254004
114neuronal action potential (GO:0019228)2.85709954
115mitotic chromosome condensation (GO:0007076)2.85695766
116protein K48-linked deubiquitination (GO:0071108)2.85313004
117primary amino compound metabolic process (GO:1901160)2.84967433
118spinal cord motor neuron differentiation (GO:0021522)2.84898448
119mitotic sister chromatid segregation (GO:0000070)2.84727849
120retrograde transport, vesicle recycling within Golgi (GO:0000301)2.84228806
121paraxial mesoderm development (GO:0048339)2.83093325
122negative regulation of systemic arterial blood pressure (GO:0003085)2.81863148
123microtubule organizing center organization (GO:0031023)2.81152041
124reflex (GO:0060004)2.80383270
125behavioral response to ethanol (GO:0048149)2.80254361
126microtubule anchoring (GO:0034453)2.79319952
127mismatch repair (GO:0006298)2.78501010
128G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.78424146
129retinal cone cell development (GO:0046549)2.76835616
130spindle checkpoint (GO:0031577)2.74968840
131regulation of DNA-dependent DNA replication (GO:0090329)2.74757990
132central nervous system neuron axonogenesis (GO:0021955)2.74640200
133protein K11-linked deubiquitination (GO:0035871)2.73448831
134thyroid hormone metabolic process (GO:0042403)2.73419769
135poly(A)+ mRNA export from nucleus (GO:0016973)2.72872655
136replication fork processing (GO:0031297)2.71573911
137rRNA catabolic process (GO:0016075)2.71037577
138regulation of sarcomere organization (GO:0060297)2.70529387
139protein localization to microtubule cytoskeleton (GO:0072698)2.70436476
140regulation of mitotic metaphase/anaphase transition (GO:0030071)2.70205449
141negative regulation of cell cycle G2/M phase transition (GO:1902750)2.69046410
142positive regulation of action potential (GO:0045760)2.68889820
143meiotic nuclear division (GO:0007126)2.68034324
144spindle assembly checkpoint (GO:0071173)2.67181449
145regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.64713671
146negative regulation of sodium ion transport (GO:0010766)2.64340316
147membrane depolarization during action potential (GO:0086010)2.64128801
148positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.64041170
149positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.64041170
150positive regulation of mitotic sister chromatid separation (GO:1901970)2.64041170
151kidney morphogenesis (GO:0060993)2.63705516
152negative regulation of protein localization to cell surface (GO:2000009)2.63695101
153regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.62187866
154maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61427589
155regulation of histone H3-K9 methylation (GO:0051570)2.61309403
156photoreceptor cell maintenance (GO:0045494)2.61214779
157negative regulation of mitotic sister chromatid separation (GO:2000816)2.60154155
158negative regulation of mitotic sister chromatid segregation (GO:0033048)2.60154155
159negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.60154155
160negative regulation of sister chromatid segregation (GO:0033046)2.60154155
161regulation of RNA export from nucleus (GO:0046831)2.60033266
162positive regulation of DNA-dependent DNA replication (GO:2000105)2.59709727
163cellular ketone body metabolic process (GO:0046950)2.59494073
164cAMP catabolic process (GO:0006198)2.59135881
165protein localization to Golgi apparatus (GO:0034067)2.59026824
166DNA strand renaturation (GO:0000733)2.58238582
167regulation of sister chromatid segregation (GO:0033045)2.58192639
168regulation of mitotic sister chromatid segregation (GO:0033047)2.58192639
169oxidative demethylation (GO:0070989)2.58038517
170regulation of collateral sprouting (GO:0048670)2.57949165
171central nervous system projection neuron axonogenesis (GO:0021952)2.55112602
172protein K63-linked deubiquitination (GO:0070536)2.54862340
173regulation of short-term neuronal synaptic plasticity (GO:0048172)2.51268612
174cardiovascular system development (GO:0072358)2.50673834
175smoothened signaling pathway (GO:0007224)2.49920150
176photoreceptor cell development (GO:0042461)2.49900243
177sulfation (GO:0051923)2.49695508
178nucleus localization (GO:0051647)2.49671972
179transmission of nerve impulse (GO:0019226)2.47097652
180protein polyglutamylation (GO:0018095)2.45437978
181microtubule bundle formation (GO:0001578)2.43054991
182negative regulation of mast cell activation (GO:0033004)2.42768783
183benzene-containing compound metabolic process (GO:0042537)2.42537040

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.87374745
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.17338186
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.87446911
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.59483519
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51848200
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.13658461
7EZH2_22144423_ChIP-Seq_EOC_Human2.90246838
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.70390612
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.69167792
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.68046685
11ZNF274_21170338_ChIP-Seq_K562_Hela2.65721361
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.60963943
13FUS_26573619_Chip-Seq_HEK293_Human2.48040009
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40132131
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36829355
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.34524245
17EWS_26573619_Chip-Seq_HEK293_Human2.30816171
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25581725
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.06406758
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95534147
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94223944
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.93674187
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91170890
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.89901901
25GBX2_23144817_ChIP-Seq_PC3_Human1.88193732
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85808013
27NR3C1_21868756_ChIP-Seq_MCF10A_Human1.73567920
28P300_19829295_ChIP-Seq_ESCs_Human1.70241011
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67974109
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65979197
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64369036
32* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62359130
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61980706
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61704990
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61704990
36BCAT_22108803_ChIP-Seq_LS180_Human1.61685541
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.61019771
38AR_21909140_ChIP-Seq_LNCAP_Human1.58467421
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57395474
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.56612097
41AR_25329375_ChIP-Seq_VCAP_Human1.53208646
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52999094
43AR_21572438_ChIP-Seq_LNCaP_Human1.52614073
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.52515937
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.51097892
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49417789
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.48485915
48E2F1_18555785_Chip-Seq_ESCs_Mouse1.48198145
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.45553048
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44481412
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43919390
52SUZ12_18555785_Chip-Seq_ESCs_Mouse1.43683900
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43679648
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43390476
55AHR_22903824_ChIP-Seq_MCF-7_Human1.42066048
56ELK1_19687146_ChIP-ChIP_HELA_Human1.41805256
57STAT3_23295773_ChIP-Seq_U87_Human1.39930059
58DROSHA_22980978_ChIP-Seq_HELA_Human1.39749365
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.38936715
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.38388613
61* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38254882
62* P53_22387025_ChIP-Seq_ESCs_Mouse1.37239950
63* RUNX2_22187159_ChIP-Seq_PCA_Human1.36300735
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35674913
65TCF4_23295773_ChIP-Seq_U87_Human1.34270202
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34091533
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33267682
68TCF4_22108803_ChIP-Seq_LS180_Human1.31099214
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.30833118
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.29525892
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.29355835
72REST_21632747_ChIP-Seq_MESCs_Mouse1.29320056
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29170976
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29075981
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25659366
76SMAD4_21799915_ChIP-Seq_A2780_Human1.25557810
77EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25178234
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25086941
79OCT4_18555785_Chip-Seq_ESCs_Mouse1.24783493
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.23325108
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.22920507
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22504151
83ER_23166858_ChIP-Seq_MCF-7_Human1.22461580
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21458058
85STAT3_18555785_Chip-Seq_ESCs_Mouse1.20549120
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20290937
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.19994647
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19991286
89P300_18555785_Chip-Seq_ESCs_Mouse1.18262834
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17360698
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17314075
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17290525
93SOX2_21211035_ChIP-Seq_LN229_Gbm1.16464843
94LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15947072
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15838733
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15833650
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14070319
98TP53_16413492_ChIP-PET_HCT116_Human1.13952894
99RNF2_27304074_Chip-Seq_NSC_Mouse1.12791685
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12327278
101KDM2B_26808549_Chip-Seq_REH_Human1.10430107
102ZFX_18555785_Chip-Seq_ESCs_Mouse1.10005602
103* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09798671
104NMYC_18555785_Chip-Seq_ESCs_Mouse1.08952808
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.08184451
106* SOX2_18555785_Chip-Seq_ESCs_Mouse1.08022310
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07955410
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.07934488
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07485680
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06892086
111RXR_22108803_ChIP-Seq_LS180_Human1.05606085
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05395911
113RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05329324
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05229500
115BRD4_25478319_ChIP-Seq_HGPS_Human1.04254474
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04147173
117CBP_20019798_ChIP-Seq_JUKART_Human1.04147173
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03916797
119NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03916797
120PU1_27457419_Chip-Seq_LIVER_Mouse1.03268803
121SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03218183
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02982009
123SOX2_19829295_ChIP-Seq_ESCs_Human1.02851302
124NANOG_19829295_ChIP-Seq_ESCs_Human1.02851302
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02696845
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02695578
127JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01913931
128OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01069685
129TCF4_18268006_ChIP-ChIP_LS174T_Human1.00278120
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99881417
131PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99405018
132SOX9_26525672_Chip-Seq_HEART_Mouse0.99297450
133TAF15_26573619_Chip-Seq_HEK293_Human0.99101624
134CTCF_18555785_Chip-Seq_ESCs_Mouse0.98772403
135SMAD_19615063_ChIP-ChIP_OVARY_Human0.97416799
136KLF4_18555785_Chip-Seq_ESCs_Mouse0.97252848
137VDR_22108803_ChIP-Seq_LS180_Human0.96928439
138ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95994867
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94581504
140IGF1R_20145208_ChIP-Seq_DFB_Human0.94105912
141IRF1_19129219_ChIP-ChIP_H3396_Human0.93918972
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93197093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.06751645
2MP0000566_synostosis3.92588257
3MP0008057_abnormal_DNA_replication3.22417070
4MP0010094_abnormal_chromosome_stability3.09549509
5MP0009697_abnormal_copulation2.89817454
6MP0003787_abnormal_imprinting2.76608837
7MP0003195_calcinosis2.72594836
8MP0009046_muscle_twitch2.58429809
9MP0008058_abnormal_DNA_repair2.56734223
10MP0004043_abnormal_pH_regulation2.51160808
11MP0008877_abnormal_DNA_methylation2.35699150
12MP0003880_abnormal_central_pattern2.31653235
13MP0001968_abnormal_touch/_nociception2.27980809
14MP0002938_white_spotting2.26877737
15MP0002102_abnormal_ear_morphology2.18333372
16MP0003111_abnormal_nucleus_morphology2.17021368
17MP0003121_genomic_imprinting2.11228665
18MP0010386_abnormal_urinary_bladder2.07036476
19MP0001293_anophthalmia2.05916582
20MP0009745_abnormal_behavioral_response2.00671647
21MP0003077_abnormal_cell_cycle2.00289319
22MP0006292_abnormal_olfactory_placode1.93400108
23MP0002736_abnormal_nociception_after1.92685177
24MP0001984_abnormal_olfaction1.92021108
25MP0001501_abnormal_sleep_pattern1.84878392
26MP0003937_abnormal_limbs/digits/tail_de1.84685046
27MP0008004_abnormal_stomach_pH1.79932888
28MP0002928_abnormal_bile_duct1.78696491
29MP0003646_muscle_fatigue1.75923500
30MP0006276_abnormal_autonomic_nervous1.73379735
31MP0000427_abnormal_hair_cycle1.73054486
32MP0004142_abnormal_muscle_tone1.71060822
33MP0001486_abnormal_startle_reflex1.70765792
34MP0002735_abnormal_chemical_nociception1.69110149
35MP0002272_abnormal_nervous_system1.69078588
36MP0001188_hyperpigmentation1.67698417
37MP0003941_abnormal_skin_development1.65949675
38MP0003950_abnormal_plasma_membrane1.65077565
39MP0000778_abnormal_nervous_system1.64456532
40MP0003693_abnormal_embryo_hatching1.60106734
41MP0008007_abnormal_cellular_replicative1.57764314
42MP0003890_abnormal_embryonic-extraembry1.57263143
43MP0002572_abnormal_emotion/affect_behav1.51537735
44MP0002653_abnormal_ependyma_morphology1.51491709
45MP0005645_abnormal_hypothalamus_physiol1.50482722
46MP0002210_abnormal_sex_determination1.49818411
47MP0005386_behavior/neurological_phenoty1.49102506
48MP0004924_abnormal_behavior1.49102506
49MP0002064_seizures1.47117959
50MP0003123_paternal_imprinting1.43119340
51MP0006072_abnormal_retinal_apoptosis1.41674789
52MP0005646_abnormal_pituitary_gland1.40745505
53MP0001929_abnormal_gametogenesis1.40021741
54MP0000383_abnormal_hair_follicle1.38220300
55MP0002557_abnormal_social/conspecific_i1.38104070
56MP0003635_abnormal_synaptic_transmissio1.36570442
57MP0010307_abnormal_tumor_latency1.35172037
58MP0001970_abnormal_pain_threshold1.33033479
59MP0002734_abnormal_mechanical_nocicepti1.31791530
60MP0002067_abnormal_sensory_capabilities1.31393963
61MP0008961_abnormal_basal_metabolism1.30969994
62MP0003698_abnormal_male_reproductive1.30413971
63MP0008789_abnormal_olfactory_epithelium1.27848744
64MP0005503_abnormal_tendon_morphology1.27560581
65MP0005423_abnormal_somatic_nervous1.25701846
66MP0004264_abnormal_extraembryonic_tissu1.25645445
67MP0003183_abnormal_peptide_metabolism1.25007935
68MP0002876_abnormal_thyroid_physiology1.24881168
69MP0005551_abnormal_eye_electrophysiolog1.24376678
70MP0003136_yellow_coat_color1.23941653
71MP0005174_abnormal_tail_pigmentation1.23255954
72MP0002063_abnormal_learning/memory/cond1.22877464
73MP0001986_abnormal_taste_sensitivity1.21644125
74MP0001324_abnormal_eye_pigmentation1.20450788
75MP0002837_dystrophic_cardiac_calcinosis1.20266371
76MP0001286_abnormal_eye_development1.19906785
77MP0005391_vision/eye_phenotype1.19576622
78MP0005410_abnormal_fertilization1.19408906
79MP0002092_abnormal_eye_morphology1.17836170
80MP0004133_heterotaxia1.17276103
81MP0008872_abnormal_physiological_respon1.15060142
82MP0009703_decreased_birth_body1.14744394
83MP0002233_abnormal_nose_morphology1.14299733
84MP0002184_abnormal_innervation1.13757112
85MP0002109_abnormal_limb_morphology1.13567119
86MP0005253_abnormal_eye_physiology1.11570764
87MP0005187_abnormal_penis_morphology1.11046849
88MP0000432_abnormal_head_morphology1.10764210
89MP0004145_abnormal_muscle_electrophysio1.10640807
90MP0004147_increased_porphyrin_level1.09479597
91MP0001145_abnormal_male_reproductive1.08781695
92MP0002733_abnormal_thermal_nociception1.07944062
93MP0002396_abnormal_hematopoietic_system1.07696760
94MP0000955_abnormal_spinal_cord1.06907926
95MP0002095_abnormal_skin_pigmentation1.06274243
96MP0010030_abnormal_orbit_morphology1.06147370
97MP0003252_abnormal_bile_duct1.05947815
98MP0003755_abnormal_palate_morphology1.05632735
99MP0002009_preneoplasia1.05524420
100MP0002160_abnormal_reproductive_system1.05406274
101MP0000653_abnormal_sex_gland1.04253703
102MP0008932_abnormal_embryonic_tissue1.04040067
103MP0004957_abnormal_blastocyst_morpholog1.04019879
104MP0002752_abnormal_somatic_nervous1.03526038
105MP0003935_abnormal_craniofacial_develop1.02874990
106MP0010678_abnormal_skin_adnexa1.02433366
107MP0004885_abnormal_endolymph1.02281369
108MP0002234_abnormal_pharynx_morphology1.01466610
109MP0000428_abnormal_craniofacial_morphol1.01137880
110MP0002882_abnormal_neuron_morphology1.00470210
111MP0001879_abnormal_lymphatic_vessel1.00400961
112MP0003786_premature_aging0.99396550
113MP0003385_abnormal_body_wall0.99285979
114MP0004215_abnormal_myocardial_fiber0.96748868
115MP0003938_abnormal_ear_development0.95515047
116MP0003942_abnormal_urinary_system0.95398921
117MP0003119_abnormal_digestive_system0.94116505
118MP0004742_abnormal_vestibular_system0.94033077
119MP0005499_abnormal_olfactory_system0.93718428
120MP0005394_taste/olfaction_phenotype0.93718428
121MP0000538_abnormal_urinary_bladder0.92808130
122MP0005171_absent_coat_pigmentation0.91181165
123MP0008875_abnormal_xenobiotic_pharmacok0.90757414
124MP0002638_abnormal_pupillary_reflex0.90724516
125MP0002751_abnormal_autonomic_nervous0.90669037
126MP0004134_abnormal_chest_morphology0.90427897
127MP0004808_abnormal_hematopoietic_stem0.90256056
128MP0003137_abnormal_impulse_conducting0.89375240
129MP0002132_abnormal_respiratory_system0.87279358
130MP0002177_abnormal_outer_ear0.86761658
131MP0001672_abnormal_embryogenesis/_devel0.86070342
132MP0005380_embryogenesis_phenotype0.86070342
133MP0004130_abnormal_muscle_cell0.85979652
134MP0002098_abnormal_vibrissa_morphology0.85263794
135MP0002168_other_aberrant_phenotype0.85187491
136MP0000372_irregular_coat_pigmentation0.84460717
137MP0005257_abnormal_intraocular_pressure0.84078825
138MP0000647_abnormal_sebaceous_gland0.84069186
139MP0000350_abnormal_cell_proliferation0.83664588
140MP0001119_abnormal_female_reproductive0.83046164
141MP0004085_abnormal_heartbeat0.82878078
142MP0000026_abnormal_inner_ear0.80933390
143MP0003943_abnormal_hepatobiliary_system0.80605059
144MP0000230_abnormal_systemic_arterial0.79728574
145MP0003936_abnormal_reproductive_system0.79478348
146MP0002116_abnormal_craniofacial_bone0.78454776
147MP0005389_reproductive_system_phenotype0.78200713
148MP0002229_neurodegeneration0.78161629
149MP0000631_abnormal_neuroendocrine_gland0.77572067
150MP0009053_abnormal_anal_canal0.77332263
151MP0002085_abnormal_embryonic_tissue0.76983470
152MP0005408_hypopigmentation0.76087130
153MP0005310_abnormal_salivary_gland0.76037322
154MP0005195_abnormal_posterior_eye0.75193058
155MP0003984_embryonic_growth_retardation0.74730206
156MP0001963_abnormal_hearing_physiology0.74582387
157MP0005623_abnormal_meninges_morphology0.74388589
158MP0000462_abnormal_digestive_system0.73765550
159MP0002088_abnormal_embryonic_growth/wei0.72927884
160MP0003633_abnormal_nervous_system0.72425935
161MP0001186_pigmentation_phenotype0.71395631
162MP0000049_abnormal_middle_ear0.71072461
163MP0002152_abnormal_brain_morphology0.70568505
164MP0001440_abnormal_grooming_behavior0.70528619
165MP0001485_abnormal_pinna_reflex0.70378067
166MP0006054_spinal_hemorrhage0.69992095
167MP0002084_abnormal_developmental_patter0.69864823

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)6.33045889
2Abnormal respiratory motile cilium physiology (HP:0012261)6.23867026
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.02438904
4Abnormal respiratory epithelium morphology (HP:0012253)4.97094263
5Abnormal respiratory motile cilium morphology (HP:0005938)4.97094263
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.78029739
7Absent/shortened dynein arms (HP:0200106)4.78029739
8Genetic anticipation (HP:0003743)4.45695650
9Rhinitis (HP:0012384)4.38004204
10Hyperventilation (HP:0002883)4.36960313
11Chromsome breakage (HP:0040012)3.95129418
12Pancreatic fibrosis (HP:0100732)3.68863610
13Tubulointerstitial nephritis (HP:0001970)3.68578204
14Progressive cerebellar ataxia (HP:0002073)3.65106196
15Abnormality of midbrain morphology (HP:0002418)3.60247678
16Molar tooth sign on MRI (HP:0002419)3.60247678
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.59774088
18Gaze-evoked nystagmus (HP:0000640)3.57776470
19True hermaphroditism (HP:0010459)3.50307101
20Chronic hepatic failure (HP:0100626)3.43103417
21Protruding tongue (HP:0010808)3.35851309
22Medial flaring of the eyebrow (HP:0010747)3.34883194
23Nephronophthisis (HP:0000090)3.30101278
24Volvulus (HP:0002580)3.22709888
25Pancreatic cysts (HP:0001737)3.16503161
26Congenital stationary night blindness (HP:0007642)3.02397451
27Postaxial foot polydactyly (HP:0001830)3.01018221
28Abnormality of the renal medulla (HP:0100957)2.99047868
29Congenital primary aphakia (HP:0007707)2.97696348
30Cystic liver disease (HP:0006706)2.96433771
31Broad-based gait (HP:0002136)2.96405150
32Ectopic kidney (HP:0000086)2.95938616
33Aplasia/Hypoplasia of the tibia (HP:0005772)2.87979712
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.80469032
35Bronchiectasis (HP:0002110)2.79368996
36Facial cleft (HP:0002006)2.76132146
37Nephrogenic diabetes insipidus (HP:0009806)2.76015492
38Gait imbalance (HP:0002141)2.71832086
39Median cleft lip (HP:0000161)2.65900576
40Fair hair (HP:0002286)2.62222920
41Congenital hepatic fibrosis (HP:0002612)2.61105101
42Occipital encephalocele (HP:0002085)2.60494691
43Lip pit (HP:0100267)2.55937384
44Clumsiness (HP:0002312)2.54602821
45Absent speech (HP:0001344)2.54519784
46Febrile seizures (HP:0002373)2.51509595
47Supernumerary spleens (HP:0009799)2.46575539
48Furrowed tongue (HP:0000221)2.45734540
49Prostate neoplasm (HP:0100787)2.42513993
50Attenuation of retinal blood vessels (HP:0007843)2.42177544
51Sclerocornea (HP:0000647)2.41755939
52Genital tract atresia (HP:0001827)2.41038540
53Hypoplastic labia majora (HP:0000059)2.39663109
54Duplicated collecting system (HP:0000081)2.38083901
55Decreased circulating renin level (HP:0003351)2.35696999
56Inability to walk (HP:0002540)2.35082672
57Chronic bronchitis (HP:0004469)2.33948749
58Abnormality of the renal collecting system (HP:0004742)2.33347556
59Bifid tongue (HP:0010297)2.33238226
60Poor coordination (HP:0002370)2.30408807
61Fibular hypoplasia (HP:0003038)2.29248192
62Preaxial hand polydactyly (HP:0001177)2.29152855
63Vaginal atresia (HP:0000148)2.28968796
64Type II lissencephaly (HP:0007260)2.28804280
65Abnormality of the nasal septum (HP:0000419)2.26333170
66Abnormality of chromosome stability (HP:0003220)2.26170322
67Abnormal drinking behavior (HP:0030082)2.22223302
68Polydipsia (HP:0001959)2.22223302
69Postaxial hand polydactyly (HP:0001162)2.15514574
70Focal seizures (HP:0007359)2.14749401
71Abolished electroretinogram (ERG) (HP:0000550)2.11554286
72Abnormality of the labia majora (HP:0012881)2.09821885
73Abnormal biliary tract physiology (HP:0012439)2.09511846
74Bile duct proliferation (HP:0001408)2.09511846
75Drooling (HP:0002307)2.08919484
76Cerebellar dysplasia (HP:0007033)2.08632781
77Widely spaced teeth (HP:0000687)2.08583214
7811 pairs of ribs (HP:0000878)2.06891004
79Abnormality of the renal cortex (HP:0011035)2.05571365
80Sloping forehead (HP:0000340)2.04363065
81Progressive inability to walk (HP:0002505)2.03710549
82Generalized hypopigmentation of hair (HP:0011358)2.03417084
83Tubular atrophy (HP:0000092)2.02407826
84Patellar aplasia (HP:0006443)2.01588142
85Hypochromic microcytic anemia (HP:0004840)2.00732448
86Lissencephaly (HP:0001339)1.99619654
87Absent eyebrow (HP:0002223)1.99403495
88Short foot (HP:0001773)1.99083945
89Nephroblastoma (Wilms tumor) (HP:0002667)1.98496072
90Embryonal renal neoplasm (HP:0011794)1.97482912
91Stomach cancer (HP:0012126)1.96506105
92Dialeptic seizures (HP:0011146)1.96150335
93Decreased central vision (HP:0007663)1.95668322
94Bell-shaped thorax (HP:0001591)1.95502128
95Excessive salivation (HP:0003781)1.88981705
96Abnormality of the ischium (HP:0003174)1.86538606
97Microglossia (HP:0000171)1.85072128
98Aplasia/Hypoplasia of the patella (HP:0006498)1.84817068
99Hypoplastic ischia (HP:0003175)1.84579061
100Midline defect of the nose (HP:0004122)1.84036440
101Abnormality of macular pigmentation (HP:0008002)1.83848959
102Focal motor seizures (HP:0011153)1.82672767
103Impulsivity (HP:0100710)1.82403675
104Abnormality of the preputium (HP:0100587)1.82251831
105Anencephaly (HP:0002323)1.81724886
106Large for gestational age (HP:0001520)1.79708545
107Tubulointerstitial abnormality (HP:0001969)1.76808435
108Oculomotor apraxia (HP:0000657)1.75752076
109Abnormality of DNA repair (HP:0003254)1.74416119
110Aplasia/Hypoplasia of the lens (HP:0008063)1.73339593
111Central scotoma (HP:0000603)1.73006183
112Retinitis pigmentosa (HP:0000510)1.72261219
113Broad foot (HP:0001769)1.70765611
114Preaxial foot polydactyly (HP:0001841)1.70719590
115Small hand (HP:0200055)1.70663461
116Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70494814
117Short 4th metacarpal (HP:0010044)1.70494814
118Keratoconus (HP:0000563)1.70167611
119Increased corneal curvature (HP:0100692)1.70167611
120Dandy-Walker malformation (HP:0001305)1.69348166
121Capillary hemangiomas (HP:0005306)1.69175745
122Absence seizures (HP:0002121)1.69117738
123Abnormal rod and cone electroretinograms (HP:0008323)1.67943590
124Urinary bladder sphincter dysfunction (HP:0002839)1.67034366
125Renal cortical cysts (HP:0000803)1.66911973
126Increased nuchal translucency (HP:0010880)1.66899799
127Neoplasm of the oral cavity (HP:0100649)1.66409657
128Aganglionic megacolon (HP:0002251)1.64905801
129Abnormal spermatogenesis (HP:0008669)1.62912530
130Multicystic kidney dysplasia (HP:0000003)1.62822957
131Recurrent sinusitis (HP:0011108)1.62583062
132Optic nerve coloboma (HP:0000588)1.62275986
133Truncal obesity (HP:0001956)1.61390469
134Meckel diverticulum (HP:0002245)1.61371460
135Colon cancer (HP:0003003)1.60550494
136Infertility (HP:0000789)1.60417796
137Symptomatic seizures (HP:0011145)1.60341782
138Highly arched eyebrow (HP:0002553)1.59788006
139Bony spicule pigmentary retinopathy (HP:0007737)1.59707179
140Narrow forehead (HP:0000341)1.59685406
141Abnormal lung lobation (HP:0002101)1.59353248
142Portal hypertension (HP:0001409)1.59148646
143Abnormality of the hepatic vasculature (HP:0006707)1.58854700
144Absent frontal sinuses (HP:0002688)1.58526297
145Male pseudohermaphroditism (HP:0000037)1.58458945
146Congenital sensorineural hearing impairment (HP:0008527)1.57957132
147Chorioretinal atrophy (HP:0000533)1.57883002
148Abnormality of the parietal bone (HP:0002696)1.57740514
149Hypoglycemic seizures (HP:0002173)1.56909131
150Abnormality of permanent molar morphology (HP:0011071)1.56584106
151Taurodontia (HP:0000679)1.56584106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.99736822
2LATS13.91126103
3NUAK13.50023425
4CDC72.89753423
5INSRR2.76055591
6BRD42.47482909
7TTK2.44710991
8NEK22.24222486
9MAP3K42.17431152
10ZAK2.16454286
11ADRBK22.16245763
12BMPR1B2.06387717
13PRPF4B2.05395168
14MAPK131.98211855
15PNCK1.90624546
16STK31.88320962
17ATR1.82569451
18SIK31.78288619
19SRPK11.67018310
20STK38L1.65770003
21OXSR11.64130068
22PLK41.63063819
23YES11.54252118
24MKNK21.52801113
25CHEK21.50504423
26EPHA21.49868474
27CAMK1G1.46366253
28BRSK21.45371518
29MARK11.45112720
30AKT31.43595976
31PBK1.42447832
32MKNK11.41342975
33EIF2AK11.38325921
34FRK1.38003789
35CCNB11.37835410
36MAP4K21.36554194
37ERBB31.35463288
38ATM1.25202081
39ADRBK11.24588356
40NTRK31.23383249
41PLK11.19409698
42MELK1.19252678
43TRPM71.16612024
44WNK41.12581840
45PINK11.10633672
46VRK11.10481615
47AURKB1.09886827
48TLK11.08459642
49CAMK1D1.08065457
50PAK31.06988622
51CAMKK21.05131057
52PLK31.03566558
53SIK11.03240921
54PTK2B1.01807270
55CASK0.99313647
56CHEK10.98717054
57BUB10.98368460
58SGK20.96658866
59CDK80.96182971
60STK390.95962540
61SIK20.92997797
62WNK30.90392271
63CDK60.88593922
64BCR0.87875976
65CDK190.87716426
66DYRK30.86789079
67CDK30.86099306
68ERBB20.85606024
69PIK3CA0.85085217
70PRKCE0.84354692
71PDK40.84315326
72PDK30.84315326
73CDK70.83326952
74EIF2AK20.78823328
75WEE10.78619402
76PLK20.78330122
77LMTK20.75667312
78NTRK20.75501752
79MAP3K70.73995551
80EPHA30.73760029
81TEC0.73462198
82FGFR20.73431885
83EPHA40.73108215
84GRK10.72636185
85NLK0.71712357
86PASK0.70724993
87PRKCG0.70342777
88TXK0.69750091
89CSNK1A1L0.69696078
90RPS6KA40.68895566
91DAPK20.68223158
92MAPK150.67157729
93CDK10.65901788
94STK40.63383263
95TNIK0.62366240
96MST40.61824442
97MARK30.61658665
98STK110.61168891
99PRKDC0.60064709
100NEK60.59166319
101TAOK30.59030371
102MAP2K40.57331480
103CAMK2A0.55295017
104CHUK0.54774378
105ACVR1B0.53157923
106CDK20.52494573
107FER0.51816881
108NEK90.50336492
109TGFBR10.49405872
110MAP2K70.48538119
111TIE10.48081575
112CSNK1G20.47424267
113JAK30.47396208
114PRKAA20.45839793
115TRIM280.44716165
116MAP3K140.44680221
117PDGFRB0.44241356
118CAMK10.44231926
119CDK40.43640094
120SGK10.43255092
121PDK20.41620939
122CAMK40.40554497
123PKN10.40124002
124PIK3CG0.39925009
125STK380.39710430
126SGK2230.39157724
127SGK4940.39157724
128PRKG10.38291702
129PRKACA0.37993537
130GSK3B0.37587838
131TNK20.37437687
132MAPK140.37172381
133OBSCN0.37116481
134MAPK70.36964035
135CSNK1D0.36932589
136FLT30.36622467
137CSNK1G10.36487993
138RPS6KB10.36088636
139PRKAA10.35828352
140CDC42BPA0.35809473
141FGFR10.35803945
142AURKA0.35154592
143MAPKAPK30.34827173
144CDK90.33657386
145WNK10.33089873
146IRAK10.33086753
147PRKCH0.33019546
148MAPK100.33015890
149SGK30.32222405
150KIT0.32183332
151DYRK1A0.31928953
152DYRK20.31729823
153MAP3K60.30515758
154GRK70.29744034

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034504.33480394
2Homologous recombination_Homo sapiens_hsa034403.82496498
3Fanconi anemia pathway_Homo sapiens_hsa034603.80969554
4Mismatch repair_Homo sapiens_hsa034303.76995610
5Cell cycle_Homo sapiens_hsa041103.16544772
6Nicotine addiction_Homo sapiens_hsa050333.02180565
7DNA replication_Homo sapiens_hsa030302.65196184
8RNA degradation_Homo sapiens_hsa030182.52228541
9Nucleotide excision repair_Homo sapiens_hsa034202.44576896
10Basal transcription factors_Homo sapiens_hsa030222.43726265
11Base excision repair_Homo sapiens_hsa034102.30388860
12Phototransduction_Homo sapiens_hsa047442.28273210
13Spliceosome_Homo sapiens_hsa030402.13519519
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.07799920
15Nitrogen metabolism_Homo sapiens_hsa009101.97803044
16Butanoate metabolism_Homo sapiens_hsa006501.97482558
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95802319
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92130038
19Morphine addiction_Homo sapiens_hsa050321.88517812
20Lysine degradation_Homo sapiens_hsa003101.84444199
21RNA transport_Homo sapiens_hsa030131.81941380
22Glutamatergic synapse_Homo sapiens_hsa047241.79760561
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78341827
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73826354
25Tryptophan metabolism_Homo sapiens_hsa003801.71730016
26mRNA surveillance pathway_Homo sapiens_hsa030151.71715536
27Circadian entrainment_Homo sapiens_hsa047131.68016979
28p53 signaling pathway_Homo sapiens_hsa041151.65245617
29Serotonergic synapse_Homo sapiens_hsa047261.50544640
30GABAergic synapse_Homo sapiens_hsa047271.49149700
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.44792889
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43518779
33Histidine metabolism_Homo sapiens_hsa003401.39906451
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.39704133
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36317842
36One carbon pool by folate_Homo sapiens_hsa006701.36083566
37Insulin secretion_Homo sapiens_hsa049111.30436134
38Calcium signaling pathway_Homo sapiens_hsa040201.26996939
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26493019
40Salivary secretion_Homo sapiens_hsa049701.25147259
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24988081
42Systemic lupus erythematosus_Homo sapiens_hsa053221.23605658
43Herpes simplex infection_Homo sapiens_hsa051681.21927571
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16835185
45Basal cell carcinoma_Homo sapiens_hsa052171.16720989
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14991910
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14615680
48Dopaminergic synapse_Homo sapiens_hsa047281.14085392
49Long-term depression_Homo sapiens_hsa047301.12009647
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11764509
51Pyrimidine metabolism_Homo sapiens_hsa002401.11077576
52Small cell lung cancer_Homo sapiens_hsa052221.09950003
53Mineral absorption_Homo sapiens_hsa049781.09315096
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09300522
55Caffeine metabolism_Homo sapiens_hsa002321.08567064
56TGF-beta signaling pathway_Homo sapiens_hsa043501.08196298
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07188672
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06495604
59Fatty acid biosynthesis_Homo sapiens_hsa000611.05324301
60Vascular smooth muscle contraction_Homo sapiens_hsa042701.04957956
61Cholinergic synapse_Homo sapiens_hsa047251.04011655
62MicroRNAs in cancer_Homo sapiens_hsa052061.03340439
63HTLV-I infection_Homo sapiens_hsa051660.99221051
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97861528
65Cocaine addiction_Homo sapiens_hsa050300.97397857
66Circadian rhythm_Homo sapiens_hsa047100.95815508
67Purine metabolism_Homo sapiens_hsa002300.94128155
68cAMP signaling pathway_Homo sapiens_hsa040240.93869805
69Adherens junction_Homo sapiens_hsa045200.92107788
70Renin secretion_Homo sapiens_hsa049240.91900438
71Oxytocin signaling pathway_Homo sapiens_hsa049210.91499708
72beta-Alanine metabolism_Homo sapiens_hsa004100.90742963
73Sphingolipid metabolism_Homo sapiens_hsa006000.89129745
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88745035
75Retinol metabolism_Homo sapiens_hsa008300.88240220
76Propanoate metabolism_Homo sapiens_hsa006400.88152248
77Glycerolipid metabolism_Homo sapiens_hsa005610.87552720
78ABC transporters_Homo sapiens_hsa020100.82252336
79Ovarian steroidogenesis_Homo sapiens_hsa049130.81030316
80Amphetamine addiction_Homo sapiens_hsa050310.80711767
81Gastric acid secretion_Homo sapiens_hsa049710.79485518
82Viral carcinogenesis_Homo sapiens_hsa052030.78223626
83Regulation of autophagy_Homo sapiens_hsa041400.76070587
84Oocyte meiosis_Homo sapiens_hsa041140.74733990
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73800798
86Prostate cancer_Homo sapiens_hsa052150.73047141
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71811584
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71687194
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.70176428
90Notch signaling pathway_Homo sapiens_hsa043300.67308332
91Arachidonic acid metabolism_Homo sapiens_hsa005900.67261923
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66097975
93Wnt signaling pathway_Homo sapiens_hsa043100.66010732
94Glutathione metabolism_Homo sapiens_hsa004800.65523582
95Sulfur metabolism_Homo sapiens_hsa009200.64355687
96Vitamin B6 metabolism_Homo sapiens_hsa007500.64019951
97Protein export_Homo sapiens_hsa030600.62955753
98Hedgehog signaling pathway_Homo sapiens_hsa043400.62647409
99Peroxisome_Homo sapiens_hsa041460.62264064
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.61842965
101FoxO signaling pathway_Homo sapiens_hsa040680.60559816
102Epstein-Barr virus infection_Homo sapiens_hsa051690.59679330
103Hippo signaling pathway_Homo sapiens_hsa043900.58645127
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58289645
105Dorso-ventral axis formation_Homo sapiens_hsa043200.56921995
106Pathways in cancer_Homo sapiens_hsa052000.56497672
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56225996
108RNA polymerase_Homo sapiens_hsa030200.53638302
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53042300
110Ras signaling pathway_Homo sapiens_hsa040140.52618270
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52407527
112Selenocompound metabolism_Homo sapiens_hsa004500.52106774
113Vitamin digestion and absorption_Homo sapiens_hsa049770.51910890
114Melanoma_Homo sapiens_hsa052180.51409012
115Steroid biosynthesis_Homo sapiens_hsa001000.50357831
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49353553
117Ether lipid metabolism_Homo sapiens_hsa005650.48431293
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47202352
119Pancreatic secretion_Homo sapiens_hsa049720.47012562
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44474177
121Hepatitis B_Homo sapiens_hsa051610.43831033
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43706549
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42169190
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.42162813
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41881942
126MAPK signaling pathway_Homo sapiens_hsa040100.41822783
127Glucagon signaling pathway_Homo sapiens_hsa049220.40848624
128Type II diabetes mellitus_Homo sapiens_hsa049300.40430572
129Olfactory transduction_Homo sapiens_hsa047400.39608895
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39217790
131Linoleic acid metabolism_Homo sapiens_hsa005910.38812559
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38567619
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38359838
134Axon guidance_Homo sapiens_hsa043600.37388711
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37287063
136Taste transduction_Homo sapiens_hsa047420.37166189
137Measles_Homo sapiens_hsa051620.37053824
138Influenza A_Homo sapiens_hsa051640.36135541
139Renin-angiotensin system_Homo sapiens_hsa046140.35318477
140N-Glycan biosynthesis_Homo sapiens_hsa005100.34912069
141Chemical carcinogenesis_Homo sapiens_hsa052040.34903662
142Huntingtons disease_Homo sapiens_hsa050160.33307450
143ECM-receptor interaction_Homo sapiens_hsa045120.33218298
144Alcoholism_Homo sapiens_hsa050340.32938537
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31758507
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.31532593
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31383251
148Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31194916
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26199782
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26153201
151Hepatitis C_Homo sapiens_hsa051600.24357821
152Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23652816
153Intestinal immune network for IgA production_Homo sapiens_hsa046720.21068057
154Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20781825
155Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20666891
156Colorectal cancer_Homo sapiens_hsa052100.20537568

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