ODF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ODF3 is a component of sperm flagella outer dense fibers, which add stiffness, elastic recoil, and protection against shearing forces during sperm movement. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.97381072
2axonemal dynein complex assembly (GO:0070286)9.90455515
3motile cilium assembly (GO:0044458)9.85556732
4spermatid development (GO:0007286)9.80835058
5epithelial cilium movement (GO:0003351)9.73355843
6cilium or flagellum-dependent cell motility (GO:0001539)9.29060403
7reproduction (GO:0000003)9.19784981
8adenosine receptor signaling pathway (GO:0001973)8.97440267
9regulation of cilium movement (GO:0003352)8.95880037
10negative regulation of cell aging (GO:0090344)8.88565361
11cellular response to ATP (GO:0071318)8.78422352
12DNA strand renaturation (GO:0000733)8.44868892
13cilium movement (GO:0003341)7.88796344
14G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)7.86333900
15peptidyl-glutamic acid carboxylation (GO:0017187)7.78799522
16protein carboxylation (GO:0018214)7.78799522
17purinergic nucleotide receptor signaling pathway (GO:0035590)7.67132254
18GDP-mannose metabolic process (GO:0019673)7.63897764
19mitotic cell cycle arrest (GO:0071850)7.63365459
20regulation of synapse structural plasticity (GO:0051823)7.48175916
21meiotic chromosome segregation (GO:0045132)7.44300458
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.42909725
23single fertilization (GO:0007338)7.28804509
24sperm capacitation (GO:0048240)7.25039376
25piRNA metabolic process (GO:0034587)7.23679370
26negative regulation of inclusion body assembly (GO:0090084)7.22725382
27synaptonemal complex organization (GO:0070193)6.96542424
28lens fiber cell differentiation (GO:0070306)6.92761141
29organic cation transport (GO:0015695)6.86247546
30microtubule depolymerization (GO:0007019)6.84175785
31synaptonemal complex assembly (GO:0007130)6.79197644
32male meiosis (GO:0007140)6.77400845
33* spermatogenesis (GO:0007283)6.70194701
34* male gamete generation (GO:0048232)6.67705556
35transepithelial transport (GO:0070633)6.37954806
36detection of light stimulus involved in visual perception (GO:0050908)6.29088709
37detection of light stimulus involved in sensory perception (GO:0050962)6.29088709
38fertilization (GO:0009566)6.22488619
39* gamete generation (GO:0007276)6.14182736
40regulation of cytokine production involved in inflammatory response (GO:1900015)6.02692968
41regulation of inclusion body assembly (GO:0090083)6.02097984
42calcium ion-dependent exocytosis (GO:0017156)5.77996355
43purinergic receptor signaling pathway (GO:0035587)5.66550535
44germ cell development (GO:0007281)5.46746877
45cellular process involved in reproduction in multicellular organism (GO:0022412)5.41075469
46negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.40317858
47chromosome condensation (GO:0030261)5.37645615
48regulation of microtubule-based movement (GO:0060632)5.23551330
49positive regulation of protein kinase C signaling (GO:0090037)5.21399710
50DNA packaging (GO:0006323)5.15377620
51urinary tract smooth muscle contraction (GO:0014848)5.11950036
52ventricular system development (GO:0021591)5.09091423
53cell recognition (GO:0008037)5.07287403
54response to ATP (GO:0033198)4.97281134
55microtubule severing (GO:0051013)4.88904039
56male meiosis I (GO:0007141)4.84104254
57* multicellular organismal reproductive process (GO:0048609)4.83886802
58estrogen biosynthetic process (GO:0006703)4.82768697
59granulocyte differentiation (GO:0030851)4.81510860
60G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.78260705
61glycerol ether metabolic process (GO:0006662)4.77512813
62behavioral response to nicotine (GO:0035095)4.71515193
63spermatid nucleus differentiation (GO:0007289)4.66975874
64triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.65358703
65positive regulation of heat generation (GO:0031652)4.65332160
66chromosome organization involved in meiosis (GO:0070192)4.64585987
67DNA methylation involved in gamete generation (GO:0043046)4.64070947
68regulation of phospholipid biosynthetic process (GO:0071071)4.62430919
69left/right pattern formation (GO:0060972)4.59363516
70seminiferous tubule development (GO:0072520)4.59306961
71rRNA methylation (GO:0031167)4.53867966
72ether metabolic process (GO:0018904)4.40974650
73sensory perception of taste (GO:0050909)4.40491061
74cardiolipin metabolic process (GO:0032048)4.21985287
75meiotic nuclear division (GO:0007126)4.17460567
76negative regulation of interleukin-8 production (GO:0032717)4.15882249
77chaperone-mediated protein complex assembly (GO:0051131)4.07035506
78single strand break repair (GO:0000012)4.04577064
79sulfur amino acid catabolic process (GO:0000098)3.94962841
80* multicellular organismal development (GO:0007275)3.90734471
81phosphatidylglycerol biosynthetic process (GO:0006655)3.89844580
82UV protection (GO:0009650)3.83542224
83meiosis I (GO:0007127)3.82877856
84sphingosine metabolic process (GO:0006670)3.79926623
85sexual reproduction (GO:0019953)3.79342942
86purine ribonucleotide transport (GO:0015868)3.79294103
87nucleotide-sugar biosynthetic process (GO:0009226)3.77589829
88nucleotide transmembrane transport (GO:1901679)3.76129234
89adenine nucleotide transport (GO:0051503)3.76095798
90regulation of cell aging (GO:0090342)3.72506336
91rRNA modification (GO:0000154)3.72047729
92cellular anion homeostasis (GO:0030002)3.69037078
93protein insertion into membrane (GO:0051205)3.66011074
94peristalsis (GO:0030432)3.64440895
95protein polyglutamylation (GO:0018095)3.62642985
96diol metabolic process (GO:0034311)3.61126478
97sphingomyelin metabolic process (GO:0006684)3.59246651
98regulation of heat generation (GO:0031650)3.58446846
99meiotic cell cycle (GO:0051321)3.57378704
100microtubule polymerization or depolymerization (GO:0031109)3.49835262
101sequestering of actin monomers (GO:0042989)3.49071953
102nucleoside transmembrane transport (GO:1901642)3.46640538
103negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.45112066
104grooming behavior (GO:0007625)3.43693677
105genitalia morphogenesis (GO:0035112)3.42457320
106regulation of spindle checkpoint (GO:0090231)3.42302545
107response to gravity (GO:0009629)3.42102938
108sialylation (GO:0097503)3.40344267
109mannose metabolic process (GO:0006013)3.39766111
110phosphate ion homeostasis (GO:0055062)3.38651632
111trivalent inorganic anion homeostasis (GO:0072506)3.38651632
112neuromuscular synaptic transmission (GO:0007274)3.37203995
113protein localization to cilium (GO:0061512)3.36605559
1143-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.34664697
115purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.34664697
116amino-acid betaine transport (GO:0015838)3.32754566
117carnitine transport (GO:0015879)3.32754566
118melanin biosynthetic process (GO:0042438)3.30752748
119endocytic recycling (GO:0032456)3.30710552
120DNA replication checkpoint (GO:0000076)3.29904088
121semaphorin-plexin signaling pathway (GO:0071526)3.18934453
122RNA localization (GO:0006403)3.18749431
123mitotic sister chromatid cohesion (GO:0007064)3.17990735
124carnitine transmembrane transport (GO:1902603)3.15856361
125sex determination (GO:0007530)3.15843623
126protein refolding (GO:0042026)3.15548134
127protein K11-linked deubiquitination (GO:0035871)3.14464087
128type B pancreatic cell proliferation (GO:0044342)3.13448629
129RNA destabilization (GO:0050779)3.08332155
130activation of adenylate cyclase activity (GO:0007190)3.08010641
131interferon-gamma secretion (GO:0072643)3.06438093
132polyol catabolic process (GO:0046174)3.05765143
133glycolytic process (GO:0006096)3.04959724
134nucleus organization (GO:0006997)3.03514828
135regulation of protein kinase A signaling (GO:0010738)3.02862607
136muscle fiber development (GO:0048747)3.01826645
137positive regulation of macrophage activation (GO:0043032)2.98109216
138melanin metabolic process (GO:0006582)2.96889668
139positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.95958259
140alditol metabolic process (GO:0019400)2.94437472
141polyamine biosynthetic process (GO:0006596)2.92733117
142sphingoid metabolic process (GO:0046519)2.90155241
143phosphate ion transmembrane transport (GO:0035435)2.89329508
144proline biosynthetic process (GO:0006561)2.85547711
145heme transport (GO:0015886)2.85537279
146mitochondrion distribution (GO:0048311)2.85090275
147positive regulation of blood pressure (GO:0045777)2.84492325
148monoubiquitinated protein deubiquitination (GO:0035520)2.84298808
149DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.83502606
150cilium morphogenesis (GO:0060271)2.82887554
151histone phosphorylation (GO:0016572)2.81419648
152nucleoside diphosphate phosphorylation (GO:0006165)2.80852214
153purine nucleotide transport (GO:0015865)2.79866588
154cilium organization (GO:0044782)2.79475673
155microtubule-based movement (GO:0007018)2.76152678
156regulation of meiosis (GO:0040020)2.74214746
157regulation of cilium assembly (GO:1902017)2.72716648
158reciprocal DNA recombination (GO:0035825)2.71282678
159reciprocal meiotic recombination (GO:0007131)2.71282678
160mitochondrial genome maintenance (GO:0000002)2.70953538
161meiotic cell cycle process (GO:1903046)2.70640343
162thrombin receptor signaling pathway (GO:0070493)2.70287047
163axoneme assembly (GO:0035082)2.70217228
164iron coordination entity transport (GO:1901678)2.69957356
165positive regulation of systemic arterial blood pressure (GO:0003084)2.69851578
166cilium assembly (GO:0042384)2.69732942
167synapsis (GO:0007129)2.67139925
168cellular component assembly involved in morphogenesis (GO:0010927)2.66198693
169secondary metabolite biosynthetic process (GO:0044550)2.62934572
170phosphatidylethanolamine biosynthetic process (GO:0006646)2.62553268
171keratan sulfate biosynthetic process (GO:0018146)2.62199914
172folic acid metabolic process (GO:0046655)2.61826650
173peptidyl-glutamic acid modification (GO:0018200)2.61439330
174negative regulation of organelle assembly (GO:1902116)2.61038333
175positive regulation of adenylate cyclase activity (GO:0045762)2.60813485
176regulation of nuclear cell cycle DNA replication (GO:0033262)2.60555061
177gonadal mesoderm development (GO:0007506)2.58984437
178chromatin silencing (GO:0006342)2.58969591
179intraciliary transport (GO:0042073)2.57875728
180regulation of guanylate cyclase activity (GO:0031282)2.57058386
181gene silencing by RNA (GO:0031047)2.56885887
182tRNA modification (GO:0006400)2.56535364
183dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.55727490
184glycerol metabolic process (GO:0006071)2.47975863
185mitochondrion degradation (GO:0000422)2.42930881
186gene silencing (GO:0016458)2.38973606
187GTP biosynthetic process (GO:0006183)2.36238052
188sperm motility (GO:0030317)13.8258385
189cell wall macromolecule catabolic process (GO:0016998)13.1454158
190cell wall macromolecule metabolic process (GO:0044036)13.1454158
191fusion of sperm to egg plasma membrane (GO:0007342)13.1103272
192acrosome reaction (GO:0007340)12.6636617
193sperm-egg recognition (GO:0035036)11.6095520
194acrosome assembly (GO:0001675)11.2744992
195multicellular organism reproduction (GO:0032504)10.7419699
196binding of sperm to zona pellucida (GO:0007339)10.5313066
197cell-cell recognition (GO:0009988)10.3842489
198regulation of skeletal muscle contraction (GO:0014819)10.2700360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.60370375
2EZH2_22144423_ChIP-Seq_EOC_Human4.45624418
3VDR_21846776_ChIP-Seq_THP-1_Human4.34205110
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.58690368
5* P68_20966046_ChIP-Seq_HELA_Human3.30633466
6CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.21306670
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.14862528
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.03644364
9LXR_22292898_ChIP-Seq_THP-1_Human2.89201365
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.87132533
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.80887810
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.76910404
13E2F1_20622854_ChIP-Seq_HELA_Human2.71682859
14* MAF_26560356_Chip-Seq_TH2_Human2.66328302
15XRN2_22483619_ChIP-Seq_HELA_Human2.56161523
16* BCL6_27268052_Chip-Seq_Bcells_Human2.50328073
17* BCOR_27268052_Chip-Seq_Bcells_Human2.47504281
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.44626869
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.40500593
20DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.39788350
21VDR_22108803_ChIP-Seq_LS180_Human2.36106346
22* CTCF_27219007_Chip-Seq_Bcells_Human2.32555272
23ERG_21242973_ChIP-ChIP_JURKAT_Human2.29883143
24VDR_24763502_ChIP-Seq_THP-1_Human2.26602307
25* PHF8_20622854_ChIP-Seq_HELA_Human2.25765062
26CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.23470794
27* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.23353807
28* CTCF_27219007_Chip-Seq_ERYTHROID_Human2.19299519
29GATA1_26923725_Chip-Seq_HPCs_Mouse2.18511080
30* MAF_26560356_Chip-Seq_TH1_Human2.12532610
31RARB_24833708_ChIP-Seq_LIVER_Mouse2.11345561
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.07175602
33RACK7_27058665_Chip-Seq_MCF-7_Human2.05962181
34CTCF_21964334_Chip-Seq_Bcells_Human2.02284734
35CREB1_26743006_Chip-Seq_LNCaP-abl_Human2.00961496
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.98433049
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93745464
38ZNF274_21170338_ChIP-Seq_K562_Hela1.91631678
39* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.91198694
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84551672
41UTX_26944678_Chip-Seq_JUKART_Human1.83134672
42SMC4_20622854_ChIP-Seq_HELA_Human1.80188593
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79800645
44ELK4_26923725_Chip-Seq_MESODERM_Mouse1.79464160
45CTCF_21964334_ChIP-Seq_BJAB-B_Human1.78686171
46* FOXP1_21924763_ChIP-Seq_HESCs_Human1.76483546
47STAT1_17558387_ChIP-Seq_HELA_Human1.75829469
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.75287111
49KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.74092458
50FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72918719
51MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.72715652
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.68598323
53TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.65129055
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.64861447
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.62388351
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61299750
57SOX2_22085726_ChIP-Seq_NPCs_Mouse1.61185958
58* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59871902
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59790408
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59126993
61TP53_22127205_ChIP-Seq_IMR90_Human1.57805245
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57237663
63ERA_21632823_ChIP-Seq_H3396_Human1.56216451
64GATA3_21867929_ChIP-Seq_CD8_Mouse1.55282020
65* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.54327711
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52984428
67KDM2B_26808549_Chip-Seq_DND41_Human1.52185326
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51406203
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50182980
70GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.49027290
71CREB1_26743006_Chip-Seq_LNCaP_Human1.47580292
72FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47516903
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42633991
74KDM2B_26808549_Chip-Seq_REH_Human1.42306571
75NANOG_20526341_ChIP-Seq_ESCs_Human1.41227698
76P300_27268052_Chip-Seq_Bcells_Human1.39063405
77* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38956195
78REST_21632747_ChIP-Seq_MESCs_Mouse1.38345554
79* SA1_27219007_Chip-Seq_Bcells_Human1.38059636
80* WDR5_24793694_ChIP-Seq_LNCAP_Human1.37461505
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.36999380
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.36320930
83CBP_20019798_ChIP-Seq_JUKART_Human1.35515121
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35515121
85LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34456721
86KAP1_22055183_ChIP-Seq_ESCs_Mouse1.33488117
87P53_21459846_ChIP-Seq_SAOS-2_Human1.33371651
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32413885
89CBX2_27304074_Chip-Seq_ESCs_Mouse1.29830615
90SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29724710
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29222910
92ETS1_21867929_ChIP-Seq_TH2_Mouse1.28412957
93RAD21_21589869_ChIP-Seq_MESCs_Mouse1.28096483
94OCT4_20526341_ChIP-Seq_ESCs_Human1.27978827
95TCF7_22412390_ChIP-Seq_EML_Mouse1.27345885
96GATA3_21867929_ChIP-Seq_TH1_Mouse1.25846056
97TAF2_19829295_ChIP-Seq_ESCs_Human1.25703141
98MYC_22102868_ChIP-Seq_BL_Human1.25564869
99* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25334958
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25306284
101GF1_26923725_Chip-Seq_HPCs_Mouse1.25145984
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25141747
103CIITA_25753668_ChIP-Seq_RAJI_Human1.23080479
104ELK3_25401928_ChIP-Seq_HUVEC_Human1.21817049
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.18015239
106SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17918637
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17785668
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.17573813
109TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17140160
110SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15951667
111PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15791496
112CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15585028
113CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14926276
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14618884
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13775644
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13479542
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13024177
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12636118
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12636118
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12397509
121DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12109135
122CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12028611
123MYC_27129775_Chip-Seq_CORNEA_Mouse1.11939400
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11106671
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11027059
126PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10902363
127NCOR1_26117541_ChIP-Seq_K562_Human1.10668712
128TP63_22573176_ChIP-Seq_HFKS_Human1.09749661
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09709435
130TET1_21451524_ChIP-Seq_MESCs_Mouse1.09616273
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09485679
132RUNX1_26923725_Chip-Seq_HPCs_Mouse1.09375537
133SPI1_26923725_Chip-Seq_HPCs_Mouse1.09372983
134RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09305641
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07117820
136NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07074604
137EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06474189
138ATF3_27146783_Chip-Seq_COLON_Human1.05988757
139OCT4_19829295_ChIP-Seq_ESCs_Human1.05642227
140JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05028856
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04887912
142CRX_20693478_ChIP-Seq_RETINA_Mouse1.04502813
143GATA1_19941827_ChIP-Seq_MEL86_Mouse1.04389955
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04385173
145RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03810211
146MYC_19829295_ChIP-Seq_ESCs_Human1.03478634
147RARA_24833708_ChIP-Seq_LIVER_Mouse1.03271815
148ESET_19884257_ChIP-Seq_ESCs_Mouse1.03192196
149CTCF_20526341_ChIP-Seq_ESCs_Human1.02113653
150SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01727994
151PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01638268
152ERG_20517297_ChIP-Seq_VCAP_Human1.01260410
153CTCF_26484167_Chip-Seq_Bcells_Mouse1.01188030
154SOX2_21211035_ChIP-Seq_LN229_Human1.00756403
155EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00563486
156CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98775704
157SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98480468
158NOTCH1_21737748_ChIP-Seq_TLL_Human0.97592810
159UBF1/2_26484160_Chip-Seq_HMECs_Human0.97486964
160ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97358484
161SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96375034
162PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95746415
163SOX11_22085726_ChIP-Seq_ESNs_Mouse0.95270889
164LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94506217
165NANOG_18555785_Chip-Seq_ESCs_Mouse0.94282261
166NFYB_21822215_ChIP-Seq_K562_Human0.92808345
167* ELF1_20517297_ChIP-Seq_JURKAT_Human0.91909501
168SMC3_22415368_ChIP-Seq_MEFs_Mouse0.91330754
169OCT4_18555785_Chip-Seq_ESCs_Mouse0.90987276
170FLI1_21867929_ChIP-Seq_CD8_Mouse0.89208641
171* YY1_22570637_ChIP-Seq_MALME-3M_Human0.88930984
172NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88784023
173OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87511920
174PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86628779
175STAT3_18555785_ChIP-Seq_MESCs_Mouse0.86442448
176GF1B_26923725_Chip-Seq_HPCs_Mouse0.86026075
177P53_22387025_ChIP-Seq_ESCs_Mouse0.85884375
178SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85794638
179TBL1_22424771_ChIP-Seq_293T_Human0.85551185
180RNF2_27304074_Chip-Seq_NSC_Mouse0.85472810

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation7.94600076
2MP0003698_abnormal_male_reproductive6.02968036
3MP0003136_yellow_coat_color5.57837069
4MP0001929_abnormal_gametogenesis5.50846194
5MP0008877_abnormal_DNA_methylation3.77001675
6MP0002210_abnormal_sex_determination3.35109028
7MP0002161_abnormal_fertility/fecundity3.29508661
8MP0005670_abnormal_white_adipose3.14209252
9MP0001188_hyperpigmentation3.13675202
10MP0005083_abnormal_biliary_tract3.13068643
11MP0008875_abnormal_xenobiotic_pharmacok3.05147352
12MP0005409_darkened_coat_color2.99176280
13MP0001145_abnormal_male_reproductive2.85180432
14MP0001756_abnormal_urination2.67462635
15MP0002638_abnormal_pupillary_reflex2.66124797
16MP0000653_abnormal_sex_gland2.46464090
17MP0002653_abnormal_ependyma_morphology2.34373581
18MP0005410_abnormal_fertilization16.6164407
19MP0003453_abnormal_keratinocyte_physiol1.76853185
20MP0004381_abnormal_hair_follicle1.73878050
21MP0004233_abnormal_muscle_weight1.72367641
22MP0000750_abnormal_muscle_regeneration1.66108374
23MP0002160_abnormal_reproductive_system1.64173353
24MP0005330_cardiomyopathy1.59863973
25MP0001919_abnormal_reproductive_system1.59331385
26MP0003646_muscle_fatigue1.53882757
27MP0002735_abnormal_chemical_nociception1.52839378
28MP0005623_abnormal_meninges_morphology1.37346416
29MP0005332_abnormal_amino_acid1.32156195
30MP0000538_abnormal_urinary_bladder1.31804895
31MP0005464_abnormal_platelet_physiology1.29567856
32MP0001984_abnormal_olfaction1.26756582
33MP0005501_abnormal_skin_physiology1.21573761
34MP0001664_abnormal_digestion1.16192458
35MP0002282_abnormal_trachea_morphology1.11758817
36MP0002234_abnormal_pharynx_morphology1.08718938
37MP0005084_abnormal_gallbladder_morpholo1.08445299
38MP0000013_abnormal_adipose_tissue1.07430502
39MP0001958_emphysema1.06344457
40MP0002254_reproductive_system_inflammat1.05379933
41MP0005365_abnormal_bile_salt1.04303035
42MP0004043_abnormal_pH_regulation1.03307230
43MP0001765_abnormal_ion_homeostasis1.03102656
44MP0010386_abnormal_urinary_bladder1.02675745
45MP0001873_stomach_inflammation0.93394503
46MP0000747_muscle_weakness0.90502637
47MP0000470_abnormal_stomach_morphology0.88903174
48MP0004215_abnormal_myocardial_fiber0.88061570
49MP0001970_abnormal_pain_threshold0.86444259
50MP0005058_abnormal_lysosome_morphology0.86201462
51MP0009046_muscle_twitch0.84906606
52MP0003115_abnormal_respiratory_system0.83214064
53MP0005647_abnormal_sex_gland0.82540340
54MP0003137_abnormal_impulse_conducting0.82055161
55MP0005584_abnormal_enzyme/coenzyme_acti0.81854477
56MP0005389_reproductive_system_phenotype0.80642504
57MP0002909_abnormal_adrenal_gland0.80355077
58MP0008058_abnormal_DNA_repair0.78774274
59MP0003303_peritoneal_inflammation0.77706007
60MP0005257_abnormal_intraocular_pressure0.76235698
61MP0009643_abnormal_urine_homeostasis0.72183898
62MP0001905_abnormal_dopamine_level0.71996437
63MP0000367_abnormal_coat/_hair0.71725748
64MP0008995_early_reproductive_senescence0.71319074
65MP0003806_abnormal_nucleotide_metabolis0.69695135
66MP0010771_integument_phenotype0.67275964
67MP0000230_abnormal_systemic_arterial0.63777610
68MP0003011_delayed_dark_adaptation0.62992774
69MP0005377_hearing/vestibular/ear_phenot0.62491057
70MP0003878_abnormal_ear_physiology0.62491057
71MP0003705_abnormal_hypodermis_morpholog0.62028271
72MP0003448_altered_tumor_morphology0.61573799
73MP0005666_abnormal_adipose_tissue0.60271758
74MP0005167_abnormal_blood-brain_barrier0.59212951
75MP0000003_abnormal_adipose_tissue0.56776252
76MP0005636_abnormal_mineral_homeostasis0.55354434
77MP0002136_abnormal_kidney_physiology0.55244503
78MP0002118_abnormal_lipid_homeostasis0.54653872
79MP0001191_abnormal_skin_condition0.54444779
80MP0002269_muscular_atrophy0.54206677
81MP0009931_abnormal_skin_appearance0.53063482
82MP0001324_abnormal_eye_pigmentation0.52598323
83MP0003091_abnormal_cell_migration0.52299923
84MP0008872_abnormal_physiological_respon0.51972736
85MP0003077_abnormal_cell_cycle0.51674564
86MP0002019_abnormal_tumor_incidence0.49237232
87MP0003283_abnormal_digestive_organ0.48948982
88MP0008874_decreased_physiological_sensi0.48176432
89MP0000534_abnormal_ureter_morphology0.47967742
90MP0005023_abnormal_wound_healing0.47947991
91MP0002736_abnormal_nociception_after0.47387347
92MP0001346_abnormal_lacrimal_gland0.47339497
93MP0005076_abnormal_cell_differentiation0.46444396
94MP0009384_cardiac_valve_regurgitation0.45630133
95MP0003699_abnormal_female_reproductive0.44848967
96MP0010329_abnormal_lipoprotein_level0.43891726
97MP0009278_abnormal_bone_marrow0.43196117
98MP0002933_joint_inflammation0.43083549
99MP0000358_abnormal_cell_content/0.42758081
100MP0001293_anophthalmia0.42471239
101MP0001784_abnormal_fluid_regulation0.42063784
102MP0003329_amyloid_beta_deposits0.41561192
103MP0002075_abnormal_coat/hair_pigmentati0.40915502
104MP0000569_abnormal_digit_pigmentation0.40872793
105MP0004133_heterotaxia0.40736168
106MP0002102_abnormal_ear_morphology0.40505402
107MP0010094_abnormal_chromosome_stability0.40212857
108MP0009115_abnormal_fat_cell0.39648679
109MP0009642_abnormal_blood_homeostasis0.39086073
110MP0010155_abnormal_intestine_physiology0.39074065
111MP0004147_increased_porphyrin_level0.39069516
112MP0005551_abnormal_eye_electrophysiolog0.38233132
113MP0003942_abnormal_urinary_system0.37928903
114MP0002928_abnormal_bile_duct0.37526887
115MP0003111_abnormal_nucleus_morphology0.37370232
116MP0005253_abnormal_eye_physiology0.36491661
117MP0004036_abnormal_muscle_relaxation0.35921919
118MP0001764_abnormal_homeostasis0.35893749
119MP0003950_abnormal_plasma_membrane0.34986507
120MP0001663_abnormal_digestive_system0.34731389
121MP0004197_abnormal_fetal_growth/weight/0.34354451
122MP0001545_abnormal_hematopoietic_system0.34000638
123MP0005397_hematopoietic_system_phenotyp0.34000638
124MP0006036_abnormal_mitochondrial_physio0.33739835
125MP0003632_abnormal_nervous_system0.33293377
126MP0003879_abnormal_hair_cell0.33068888
127MP0004811_abnormal_neuron_physiology0.32261062
128MP0009840_abnormal_foam_cell0.30717903
129MP0005391_vision/eye_phenotype0.30605178
130MP0003861_abnormal_nervous_system0.28948330
131MP0002971_abnormal_brown_adipose0.27667242
132MP0001119_abnormal_female_reproductive0.27129934
133MP0001968_abnormal_touch/_nociception0.27046963
134MP0005174_abnormal_tail_pigmentation0.26685968
135MP0002152_abnormal_brain_morphology0.26567506
136MP0004742_abnormal_vestibular_system0.26227078
137MP0008961_abnormal_basal_metabolism0.25526513
138MP0001661_extended_life_span0.24564456
139MP0003948_abnormal_gas_homeostasis0.23887417
140MP0003633_abnormal_nervous_system0.21801010
141MP0003045_fibrosis0.21424292
142MP0003959_abnormal_lean_body0.21330100
143MP0001730_embryonic_growth_arrest0.21207689
144MP0002169_no_abnormal_phenotype0.20965151
145MP0002873_normal_phenotype0.20707566
146MP0004019_abnormal_vitamin_homeostasis0.19716693
147MP0001986_abnormal_taste_sensitivity0.18952745
148MP0001502_abnormal_circadian_rhythm0.18125972
149MP0002092_abnormal_eye_morphology0.17786553
150MP0004130_abnormal_muscle_cell0.17507735
151MP0005423_abnormal_somatic_nervous0.16801841
152MP0003631_nervous_system_phenotype0.16478017
153MP0000015_abnormal_ear_pigmentation0.16166772
154MP0002295_abnormal_pulmonary_circulatio0.15635424
155MP0000604_amyloidosis0.15070459
156MP0005375_adipose_tissue_phenotype0.14880228
157MP0003936_abnormal_reproductive_system0.14760857
158MP0000751_myopathy0.14581722
159MP0005195_abnormal_posterior_eye0.14244213
160MP0001270_distended_abdomen0.13964764
161MP0000462_abnormal_digestive_system0.13446944
162MP0003786_premature_aging0.13392445
163MP0006035_abnormal_mitochondrial_morpho0.13276449
164MP0002572_abnormal_emotion/affect_behav0.12722861
165MP0008770_decreased_survivor_rate0.12455241
166MP0004808_abnormal_hematopoietic_stem0.12445016
167MP0000001_mammalian_phenotype0.12404040
168MP0004270_analgesia0.12051013
169MP0000313_abnormal_cell_death0.11686494
170MP0002229_neurodegeneration0.11229613
171MP0002752_abnormal_somatic_nervous0.10883706

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.24438342
2Abnormal respiratory motile cilium morphology (HP:0005938)9.24438342
3Abnormal respiratory motile cilium physiology (HP:0012261)9.13269502
4Rhinitis (HP:0012384)7.50940341
5Chronic bronchitis (HP:0004469)7.21272554
6Infertility (HP:0000789)6.98912377
7Abnormal ciliary motility (HP:0012262)6.98282962
8Nasal polyposis (HP:0100582)6.37148503
9Rib fusion (HP:0000902)6.35661979
10Testicular atrophy (HP:0000029)6.34233127
11Attenuation of retinal blood vessels (HP:0007843)5.75674742
12Abnormality of the nasal mucosa (HP:0000433)5.21713485
13Mesangial abnormality (HP:0001966)5.05030682
14Rectovaginal fistula (HP:0000143)5.01407348
15Rectal fistula (HP:0100590)5.01407348
16Poikiloderma (HP:0001029)4.70744582
17Thin bony cortex (HP:0002753)4.69070967
18Abnormality of the intrinsic pathway (HP:0010989)4.66202040
19Joint hemorrhage (HP:0005261)4.63007564
20Intestinal fistula (HP:0100819)4.61684315
21Male infertility (HP:0003251)4.59939532
22Bronchitis (HP:0012387)4.53312617
23Vaginal fistula (HP:0004320)4.49957307
24Facial diplegia (HP:0001349)4.48611724
25Popliteal pterygium (HP:0009756)4.48060886
26Prolonged partial thromboplastin time (HP:0003645)4.40917477
27Bronchiectasis (HP:0002110)4.39525864
28Annular pancreas (HP:0001734)4.33800019
29Facial hemangioma (HP:0000329)4.27883321
30Congenital stationary night blindness (HP:0007642)4.27351197
31Nephronophthisis (HP:0000090)4.17473622
32Akinesia (HP:0002304)4.16638705
33Ulnar bowing (HP:0003031)4.05377810
34Renal Fanconi syndrome (HP:0001994)3.97576343
35Aplasia of the musculature (HP:0100854)3.84755722
36Fetal akinesia sequence (HP:0001989)3.81455262
37Increased hepatocellular lipid droplets (HP:0006565)3.70814525
38Coronal craniosynostosis (HP:0004440)3.67847420
39Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.67652325
40Turricephaly (HP:0000262)3.64610090
41Abnormal spermatogenesis (HP:0008669)3.62379297
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.58832252
43Lipid accumulation in hepatocytes (HP:0006561)3.49848061
44Bony spicule pigmentary retinopathy (HP:0007737)3.48908158
45Chorioretinal atrophy (HP:0000533)3.47217391
46Delayed epiphyseal ossification (HP:0002663)3.45511744
47Squamous cell carcinoma (HP:0002860)3.39551026
48Hypoalbuminemia (HP:0003073)3.33603162
49Abnormal albumin level (HP:0012116)3.33603162
50Hypophosphatemic rickets (HP:0004912)3.30268136
51Recurrent otitis media (HP:0000403)3.25486821
52Short chin (HP:0000331)3.18257361
53Atrioventricular block (HP:0001678)3.16846497
54Patellar aplasia (HP:0006443)3.13563187
55Abnormality of the renal medulla (HP:0100957)3.13175506
56Amniotic constriction ring (HP:0009775)3.12785206
57Abnormality of placental membranes (HP:0011409)3.12785206
58Enlarged epiphyses (HP:0010580)3.12417417
59Recurrent sinusitis (HP:0011108)3.03125983
60Abnormality of the costochondral junction (HP:0000919)3.00773518
61Abnormality of the common coagulation pathway (HP:0010990)2.99584015
62Impulsivity (HP:0100710)2.96637085
63Myotonia (HP:0002486)2.95590136
64Exertional dyspnea (HP:0002875)2.95357399
65Anteriorly placed anus (HP:0001545)2.88926485
66Aplasia/Hypoplasia of the patella (HP:0006498)2.88805817
67Tubulointerstitial nephritis (HP:0001970)2.77395283
68Recurrent bronchitis (HP:0002837)2.74672660
69Increased intramyocellular lipid droplets (HP:0012240)2.69172399
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.63241466
71Tubular atrophy (HP:0000092)2.53824939
72Medial flaring of the eyebrow (HP:0010747)2.53486804
73Zonular cataract (HP:0010920)2.52947243
74Neonatal respiratory distress (HP:0002643)2.52661282
75Hyperlipoproteinemia (HP:0010980)2.51962620
76Increased muscle lipid content (HP:0009058)2.51359563
77Molar tooth sign on MRI (HP:0002419)2.47127199
78Abnormality of midbrain morphology (HP:0002418)2.47127199
79Cholecystitis (HP:0001082)2.43485228
80Abnormal gallbladder physiology (HP:0012438)2.43485228
81Flat occiput (HP:0005469)2.43447089
82Abnormality of renal resorption (HP:0011038)2.43238409
83Widely patent fontanelles and sutures (HP:0004492)2.42377290
84Gonadotropin excess (HP:0000837)2.39575960
85Capillary hemangiomas (HP:0005306)2.39393291
86Neonatal onset (HP:0003623)2.37935099
87Absent thumb (HP:0009777)2.37910230
88Tubulointerstitial abnormality (HP:0001969)2.35589402
89Azoospermia (HP:0000027)2.34003792
90Aplasia/Hypoplasia involving the musculature (HP:0001460)2.31857709
91Bowing of the arm (HP:0006488)2.31518178
92Bowed forearm bones (HP:0003956)2.31518178
93Abnormal epiphyseal ossification (HP:0010656)2.30219641
94Premature graying of hair (HP:0002216)2.26736870
95Joint stiffness (HP:0001387)2.25950231
96Increased number of teeth (HP:0011069)2.23570527
97Abnormal urine phosphate concentration (HP:0012599)2.19928990
98Choanal stenosis (HP:0000452)2.17352413
99Narrow nasal bridge (HP:0000446)2.16938729
100Cystic hygroma (HP:0000476)2.16689582
101Long clavicles (HP:0000890)2.15062834
102Birth length less than 3rd percentile (HP:0003561)2.11103082
103Dyschromatopsia (HP:0007641)2.09381588
104Abnormality of the hepatic vasculature (HP:0006707)2.05537007
105Spastic tetraparesis (HP:0001285)2.04956131
106Malignant hyperthermia (HP:0002047)2.03086637
107Short humerus (HP:0005792)2.02523730
108Respiratory difficulties (HP:0002880)2.02304430
109Heart block (HP:0012722)2.01956202
110Choroideremia (HP:0001139)2.00600954
111Epiphyseal stippling (HP:0010655)2.00522041
112Dynein arm defect of respiratory motile cilia (HP:0012255)13.2570501
113Absent/shortened dynein arms (HP:0200106)13.2570501
114Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9136120
115Epistaxis (HP:0000421)1.99726301
116Macular degeneration (HP:0000608)1.98291364
117Basal cell carcinoma (HP:0002671)1.96294852
118Thin ribs (HP:0000883)1.95810472
119Petechiae (HP:0000967)1.94682967
120Type 2 muscle fiber atrophy (HP:0003554)1.93222180
121Pterygium (HP:0001059)1.91965813
122Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91260917
123Tubulointerstitial fibrosis (HP:0005576)1.90077941
124Decreased central vision (HP:0007663)1.87518023
125Abnormal atrioventricular conduction (HP:0005150)1.86640218
126Breast hypoplasia (HP:0003187)1.84612812
127Aplasia/hypoplasia of the humerus (HP:0006507)1.81822303
128Stage 5 chronic kidney disease (HP:0003774)1.81583496
129Absent radius (HP:0003974)1.81184878
130Postaxial foot polydactyly (HP:0001830)1.81170117
131Heterotopia (HP:0002282)1.81162142
132Abnormal drinking behavior (HP:0030082)1.75135076
133Polydipsia (HP:0001959)1.75135076
134Hemorrhage of the eye (HP:0011885)1.67716666
135Congenital hepatic fibrosis (HP:0002612)1.66498339
136Renal dysplasia (HP:0000110)1.63798072
137Bile duct proliferation (HP:0001408)1.63409659
138Abnormal biliary tract physiology (HP:0012439)1.63409659
139Abnormality of the renal cortex (HP:0011035)1.62657826
140Short ribs (HP:0000773)1.62499443
141Aplasia/Hypoplasia of the lens (HP:0008063)1.62405861
142Congenital malformation of the right heart (HP:0011723)1.61553195
143Double outlet right ventricle (HP:0001719)1.61553195
144Abnormality of the lower motor neuron (HP:0002366)1.59942435
145Abnormality of the dental root (HP:0006486)1.58797590
146Taurodontia (HP:0000679)1.58797590
147Abnormality of permanent molar morphology (HP:0011071)1.58797590
148Decreased electroretinogram (ERG) amplitude (HP:0000654)1.54778514
149Abnormality of renal excretion (HP:0011036)1.53431326
150Bell-shaped thorax (HP:0001591)1.53306330
151Neurofibrillary tangles (HP:0002185)1.52379683
152Absent epiphyses (HP:0010577)1.49778477
153Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.49778477
154Abnormality of molar morphology (HP:0011070)1.48613866
155Abnormality of molar (HP:0011077)1.48613866
156Hypercholesterolemia (HP:0003124)1.47940554
157Oculomotor apraxia (HP:0000657)1.47421111
158Abnormality of the dental pulp (HP:0006479)1.46498811
159Sensory axonal neuropathy (HP:0003390)1.46159168
160Gait imbalance (HP:0002141)1.44795154
161Congenital primary aphakia (HP:0007707)1.44287505
162Postaxial hand polydactyly (HP:0001162)1.43238538
163Chronic sinusitis (HP:0011109)1.39460083
164Easy fatigability (HP:0003388)1.38663473
165Hemiparesis (HP:0001269)1.38105964
166Abnormality of dentin (HP:0010299)1.36969175
167Asymmetric septal hypertrophy (HP:0001670)1.35911836
168Deformed sella turcica (HP:0002681)1.35893496
169Cystic liver disease (HP:0006706)1.35817291
170Cerebellar dysplasia (HP:0007033)1.35311817
171Bundle branch block (HP:0011710)1.35036001
172Fatigable weakness (HP:0003473)1.31304556
173Abnormality of the neuromuscular junction (HP:0003398)1.31304556
174Facial cleft (HP:0002006)1.31142769
175Abnormal urine output (HP:0012590)1.30814439
176Fibular hypoplasia (HP:0003038)1.30587130
177Loss of speech (HP:0002371)1.29432645
178Exercise-induced myalgia (HP:0003738)1.26678287
179Retinal dysplasia (HP:0007973)1.26614159
180Hyporeflexia of lower limbs (HP:0002600)1.24520134
181Myoglobinuria (HP:0002913)1.22469666
182Cerebral inclusion bodies (HP:0100314)1.22128648
183Short femoral neck (HP:0100864)1.21501518
184Lissencephaly (HP:0001339)1.19902288
185Nephrogenic diabetes insipidus (HP:0009806)1.19875225
186Renovascular hypertension (HP:0100817)1.16888355
187Truncal obesity (HP:0001956)1.16852514
188Short thorax (HP:0010306)1.16581032
189Constricted visual fields (HP:0001133)1.16144931
190Broad distal phalanx of finger (HP:0009836)1.15978560

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.47819400
2PDK37.47819400
3TESK17.09803733
4PRKD35.76474955
5ICK4.91828205
6PDK24.84515809
7BLK3.50292667
8TLK13.39975567
9PTK2B2.29102363
10GRK62.28042919
11WNK42.14099647
12ACVR1B2.10289277
13STK382.06640582
14STK392.03259506
15ZAK1.98612508
16BMX1.97944518
17ADRBK21.90617953
18DYRK1B1.82692552
19PNCK1.82051671
20ADRBK11.81739459
21ZAP701.81042788
22STK161.71088270
23NEK21.63772419
24SIK21.57801509
25AKT31.29971744
26PIM21.29669498
27MAP2K31.24260107
28FRK1.22753487
29PDK11.15691487
30DAPK21.08833932
31TRIM281.04085118
32DYRK31.01851295
33GRK10.99696130
34MAPK150.92327409
35CSK0.92065180
36TYRO30.90512503
37PRKD10.87653674
38CDK40.83907757
39PASK0.80273777
40CHEK20.79625353
41WNK10.79364159
42TTK0.77834785
43PDPK10.76407571
44IRAK10.75153395
45IKBKB0.72078422
46TESK20.71920350
47BTK0.70948366
48RIPK40.70596706
49STK30.68529718
50MELK0.67218437
51PRKD20.67209215
52EEF2K0.67122548
53SYK0.66672192
54NUAK10.62075108
55CCNB10.61848534
56SIK10.59686593
57TBK10.59666630
58MAPK110.58932926
59CAMK1G0.54599484
60SGK4940.54409359
61SGK2230.54409359
62PINK10.53416327
63EPHB20.52636195
64MAPK120.51974557
65LYN0.51416529
66GRK50.50615745
67ERN10.50125206
68RPS6KA50.47899086
69CDK90.47036220
70MAP2K60.45225825
71TEC0.44020005
72CDK80.43809151
73NTRK20.43765295
74MUSK0.43276202
75MAPKAPK30.42420757
76MYLK0.42180454
77STK38L0.42103923
78PAK10.41038534
79RPS6KA60.40352011
80PRKCG0.40249897
81IRAK20.39769829
82LMTK20.39690226
83TRIB30.38431223
84RPS6KA20.38430728
85MARK20.38207112
86PIK3CG0.37666223
87MAP3K100.36899932
88CHEK10.36325928
89ARAF0.35985717
90TGFBR10.35131193
91IKBKE0.33475178
92DAPK30.33432849
93TAOK30.32542291
94CAMKK10.32440820
95MTOR0.31830614
96CAMKK20.31288874
97OXSR10.30956549
98ATM0.30250080
99SIK30.29395528
100PAK20.29166308
101ILK0.28964289
102ATR0.28011423
103MAPK130.25907480
104PRKACA0.24648896
105TNIK0.23980733
106RPS6KC10.23317649
107RPS6KL10.23317649
108PRKAA10.23033622
109MAPKAPK50.22391681
110PAK40.22268399
111PLK40.22010463
112ERBB20.21944092
113EPHA30.21658693
114MAP4K10.21142668
115NEK60.20822373
116PKN10.20221374
117PRKCZ0.19329319
118PLK10.18924149
119CDK150.12790284
120RPS6KA10.12284074
121PRKCQ0.12075285
122RPS6KB10.12011435
123YES10.09765860
124CDK180.09647331
125MAP3K40.09589330
126CDC70.09427059
127BRSK20.09123075
128BMPR1B0.09038584
129CDK120.09015247
130CDK11A0.08073145
131CLK10.07694299
132CSF1R0.07500537
133PIM10.06957101
134GSK3B0.06917361
135MAP3K20.05814071
136PDGFRB0.05777128
137WEE10.05759509
138CSNK2A10.05184249
139MAP2K70.05180732
140AURKA0.05079948
141PRKG10.03951857
142BRSK10.03702811
143CAMK2A0.03527528
144PRKCD0.03161649
145CDK140.03156429
146CDK10.02818180
147STK110.02797327
148PRKACG0.02680234
149PRKG20.02557068
150CDK60.02024942
151PRKCA0.01969039
152CDK30.01900528
153MAPK80.01277177
154CSNK1D0.01194521
155PRKCB0.00863740
156EGFR0.00821600
157CDK20.00590869
158RIPK1-0.0272190
159LATS1-0.0211533
160MARK1-0.0203264
161CSNK2A2-0.0164054
162TAOK1-0.0136615
163BRAF-0.0115160
164CAMK1-0.0071318

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001307.31406260
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006047.10581460
3Fatty acid biosynthesis_Homo sapiens_hsa000614.70187834
4Sulfur relay system_Homo sapiens_hsa041224.69703261
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.31331469
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.63974945
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.21154607
8Vitamin B6 metabolism_Homo sapiens_hsa007503.19955380
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.18243048
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.13071844
11Pyruvate metabolism_Homo sapiens_hsa006203.10620473
12Linoleic acid metabolism_Homo sapiens_hsa005913.05426300
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.65642935
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.57767234
15Glucagon signaling pathway_Homo sapiens_hsa049222.53719726
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.51662995
17Propanoate metabolism_Homo sapiens_hsa006402.44416195
18Sphingolipid metabolism_Homo sapiens_hsa006002.19990369
19Basal transcription factors_Homo sapiens_hsa030222.10890715
20Selenocompound metabolism_Homo sapiens_hsa004502.01834383
21Glycerolipid metabolism_Homo sapiens_hsa005611.96776098
22PPAR signaling pathway_Homo sapiens_hsa033201.95703577
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.88316868
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.87104449
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78486977
26Circadian rhythm_Homo sapiens_hsa047101.75888649
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.73483439
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.72672401
29Fructose and mannose metabolism_Homo sapiens_hsa000511.70886592
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69906900
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.68202043
32Oocyte meiosis_Homo sapiens_hsa041141.61064688
33Amphetamine addiction_Homo sapiens_hsa050311.60604752
34Dorso-ventral axis formation_Homo sapiens_hsa043201.60122562
35Pentose phosphate pathway_Homo sapiens_hsa000301.59728401
36Mineral absorption_Homo sapiens_hsa049781.50643060
37Ether lipid metabolism_Homo sapiens_hsa005651.49121898
38Fat digestion and absorption_Homo sapiens_hsa049751.47075853
39Fatty acid metabolism_Homo sapiens_hsa012121.46406354
40Fatty acid degradation_Homo sapiens_hsa000711.45001016
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.38590666
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37693023
43Fanconi anemia pathway_Homo sapiens_hsa034601.34321592
44Carbon metabolism_Homo sapiens_hsa012001.26806085
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25372556
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25187966
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23145324
48Cardiac muscle contraction_Homo sapiens_hsa042601.22897673
49Nitrogen metabolism_Homo sapiens_hsa009101.13074392
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09743347
51Renin secretion_Homo sapiens_hsa049241.06202286
52Phototransduction_Homo sapiens_hsa047441.04853322
53Hedgehog signaling pathway_Homo sapiens_hsa043401.04540515
54Nicotine addiction_Homo sapiens_hsa050331.04085769
55Antigen processing and presentation_Homo sapiens_hsa046121.00620543
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99936521
57Ovarian steroidogenesis_Homo sapiens_hsa049130.97170596
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.96469798
59Glutathione metabolism_Homo sapiens_hsa004800.96001337
60mRNA surveillance pathway_Homo sapiens_hsa030150.94307645
61Vitamin digestion and absorption_Homo sapiens_hsa049770.93905967
62Huntingtons disease_Homo sapiens_hsa050160.91013160
63Purine metabolism_Homo sapiens_hsa002300.87478459
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.86836629
65Platelet activation_Homo sapiens_hsa046110.86615551
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84811655
67Insulin secretion_Homo sapiens_hsa049110.84757015
68Collecting duct acid secretion_Homo sapiens_hsa049660.84573789
69Arachidonic acid metabolism_Homo sapiens_hsa005900.83707132
70Chemical carcinogenesis_Homo sapiens_hsa052040.83029734
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76565115
72Long-term potentiation_Homo sapiens_hsa047200.75533015
73Systemic lupus erythematosus_Homo sapiens_hsa053220.74386755
74Estrogen signaling pathway_Homo sapiens_hsa049150.73142897
75Bile secretion_Homo sapiens_hsa049760.71505190
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70826779
77RNA transport_Homo sapiens_hsa030130.70499736
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70494056
79Lysosome_Homo sapiens_hsa041420.69697004
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69016266
81Biosynthesis of amino acids_Homo sapiens_hsa012300.65856961
82Thyroid hormone synthesis_Homo sapiens_hsa049180.65574806
83ABC transporters_Homo sapiens_hsa020100.62308106
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62004045
85mTOR signaling pathway_Homo sapiens_hsa041500.59513398
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.58614508
87Other glycan degradation_Homo sapiens_hsa005110.56991208
88Hematopoietic cell lineage_Homo sapiens_hsa046400.56888669
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.56541569
90Gap junction_Homo sapiens_hsa045400.55764217
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54749546
92Calcium signaling pathway_Homo sapiens_hsa040200.53329697
93Hippo signaling pathway_Homo sapiens_hsa043900.52618574
94Protein digestion and absorption_Homo sapiens_hsa049740.52067268
95Lysine degradation_Homo sapiens_hsa003100.51567470
96Pancreatic secretion_Homo sapiens_hsa049720.51088062
97Salivary secretion_Homo sapiens_hsa049700.49932831
98Legionellosis_Homo sapiens_hsa051340.47495761
99Gastric acid secretion_Homo sapiens_hsa049710.47016454
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.46021446
101Renin-angiotensin system_Homo sapiens_hsa046140.45808120
102AMPK signaling pathway_Homo sapiens_hsa041520.45579287
103Endocytosis_Homo sapiens_hsa041440.43171576
104Synaptic vesicle cycle_Homo sapiens_hsa047210.42868120
105Alcoholism_Homo sapiens_hsa050340.42692481
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42367962
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40740381
108Melanogenesis_Homo sapiens_hsa049160.39512060
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.39130979
110Inositol phosphate metabolism_Homo sapiens_hsa005620.37426205
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37097965
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36223315
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36146400
114cAMP signaling pathway_Homo sapiens_hsa040240.34963284
115Morphine addiction_Homo sapiens_hsa050320.34137877
116Metabolic pathways_Homo sapiens_hsa011000.33874572
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32869692
118VEGF signaling pathway_Homo sapiens_hsa043700.31948768
119Taste transduction_Homo sapiens_hsa047420.31129726
120Bladder cancer_Homo sapiens_hsa052190.29191626
121Circadian entrainment_Homo sapiens_hsa047130.28879071
122Cocaine addiction_Homo sapiens_hsa050300.28244934
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27477068
124Cholinergic synapse_Homo sapiens_hsa047250.26469899
125Insulin resistance_Homo sapiens_hsa049310.26191341
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.25438432
127Homologous recombination_Homo sapiens_hsa034400.25396800
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.24322884
129Basal cell carcinoma_Homo sapiens_hsa052170.24100239
130Serotonergic synapse_Homo sapiens_hsa047260.23814956
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23632028
132MAPK signaling pathway_Homo sapiens_hsa040100.22854615
133ECM-receptor interaction_Homo sapiens_hsa045120.22585628
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20740122
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.19844494
136Type II diabetes mellitus_Homo sapiens_hsa049300.19734906
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17280366
138Wnt signaling pathway_Homo sapiens_hsa043100.16061772
139Primary immunodeficiency_Homo sapiens_hsa053400.15113521
140B cell receptor signaling pathway_Homo sapiens_hsa046620.14755659
141Intestinal immune network for IgA production_Homo sapiens_hsa046720.13876359
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13556471
143Sulfur metabolism_Homo sapiens_hsa009200.13428440
144Melanoma_Homo sapiens_hsa052180.13241781
145N-Glycan biosynthesis_Homo sapiens_hsa005100.12939986
146Retinol metabolism_Homo sapiens_hsa008300.12563890
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12235847
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11610308
149Pyrimidine metabolism_Homo sapiens_hsa002400.11517421
150HIF-1 signaling pathway_Homo sapiens_hsa040660.10758278
151Glutamatergic synapse_Homo sapiens_hsa047240.10320950
152RNA polymerase_Homo sapiens_hsa030200.10035508
153Jak-STAT signaling pathway_Homo sapiens_hsa046300.09988128
154Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.09368922
155Chemokine signaling pathway_Homo sapiens_hsa040620.09037375

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