ODF3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)7.90638408
2cilium movement (GO:0003341)7.49081858
3axoneme assembly (GO:0035082)6.19776332
4epithelial cilium movement (GO:0003351)5.84566707
5cilium or flagellum-dependent cell motility (GO:0001539)5.81767076
6GTP biosynthetic process (GO:0006183)5.62515918
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.55036308
8ribosomal small subunit assembly (GO:0000028)5.42839978
9definitive hemopoiesis (GO:0060216)5.22102575
10UTP metabolic process (GO:0046051)4.96935203
11platelet dense granule organization (GO:0060155)4.93601787
12UTP biosynthetic process (GO:0006228)4.93150052
13motile cilium assembly (GO:0044458)4.75840099
14polyketide metabolic process (GO:0030638)4.68369751
15doxorubicin metabolic process (GO:0044598)4.68369751
16daunorubicin metabolic process (GO:0044597)4.68369751
17regulation of skeletal muscle contraction (GO:0014819)4.59822607
18response to peptidoglycan (GO:0032494)4.50468006
19protein carboxylation (GO:0018214)4.35416047
20peptidyl-glutamic acid carboxylation (GO:0017187)4.35416047
21negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.33165737
22nucleoside diphosphate phosphorylation (GO:0006165)4.32123655
23CTP metabolic process (GO:0046036)4.25353840
24CTP biosynthetic process (GO:0006241)4.25353840
25DNA deamination (GO:0045006)4.23206040
26guanosine-containing compound biosynthetic process (GO:1901070)4.14758638
27regulation of cytokine production involved in inflammatory response (GO:1900015)4.12735281
28viral transcription (GO:0019083)4.11884635
29regulation of triglyceride catabolic process (GO:0010896)4.07934192
30GDP-mannose metabolic process (GO:0019673)4.07669288
31regulation of interferon-beta biosynthetic process (GO:0045357)4.06907958
32antigen processing and presentation of endogenous antigen (GO:0019883)4.04313953
33tolerance induction (GO:0002507)4.04292045
34detection of bacterium (GO:0016045)4.03063638
35detection of other organism (GO:0098543)4.02034943
36response to interferon-beta (GO:0035456)4.01304565
37antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.99558162
38pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.93313564
39ventricular system development (GO:0021591)3.91712674
40adenosine receptor signaling pathway (GO:0001973)3.90310756
41translational termination (GO:0006415)3.90091250
42negative regulation of interleukin-8 production (GO:0032717)3.89384885
43positive regulation of respiratory burst (GO:0060267)3.88727375
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.85917581
45negative regulation of cell killing (GO:0031342)3.85917581
46pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.83629678
47detection of molecule of bacterial origin (GO:0032490)3.79470170
48negative regulation of erythrocyte differentiation (GO:0045647)3.77922287
49detection of external biotic stimulus (GO:0098581)3.76948932
50mitotic cell cycle arrest (GO:0071850)3.74623260
51G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.72307515
52negative regulation of toll-like receptor signaling pathway (GO:0034122)3.65937390
53blood coagulation, intrinsic pathway (GO:0007597)3.65001203
54macrophage activation involved in immune response (GO:0002281)3.61413640
55cysteine metabolic process (GO:0006534)3.54313881
56mannose metabolic process (GO:0006013)3.53225053
57L-phenylalanine metabolic process (GO:0006558)3.48903257
58erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.48903257
59positive regulation of heat generation (GO:0031652)3.48770951
60positive regulation by symbiont of host defense response (GO:0052509)3.48221225
61modulation by symbiont of host defense response (GO:0052031)3.48221225
62modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.48221225
63modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.48221225
64positive regulation by organism of defense response of other organism involved in symbiotic interact3.48221225
65modulation by symbiont of host immune response (GO:0052553)3.48221225
66immunoglobulin mediated immune response (GO:0016064)3.47241132
67left/right axis specification (GO:0070986)3.47055459
68erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.46639322
69L-phenylalanine catabolic process (GO:0006559)3.46639322
70regulation of tolerance induction (GO:0002643)3.44903582
71flavonoid metabolic process (GO:0009812)3.44740475
72antigen processing and presentation via MHC class Ib (GO:0002475)3.44667130
73regulation of synapse structural plasticity (GO:0051823)3.44503002
74response to type I interferon (GO:0034340)3.44488815
75cellular response to ATP (GO:0071318)3.43834407
76positive regulation of tolerance induction (GO:0002645)3.42209570
77neutrophil activation involved in immune response (GO:0002283)3.39462328
78aromatic amino acid family catabolic process (GO:0009074)3.38772474
79regulation of plasminogen activation (GO:0010755)3.37981058
80cellular response to type I interferon (GO:0071357)3.37933624
81type I interferon signaling pathway (GO:0060337)3.37933624
82positive regulation of gamma-delta T cell activation (GO:0046645)3.37364651
83positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.35642925
84ribosomal small subunit biogenesis (GO:0042274)3.35552161
85translational elongation (GO:0006414)3.34175870
86S-adenosylmethionine metabolic process (GO:0046500)3.31325076
87pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.30660524
88negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.29943171
89tryptophan catabolic process (GO:0006569)3.27741716
90indole-containing compound catabolic process (GO:0042436)3.27741716
91indolalkylamine catabolic process (GO:0046218)3.27741716
92bile acid biosynthetic process (GO:0006699)3.27641403
93response to muramyl dipeptide (GO:0032495)3.27546063
94intraciliary transport (GO:0042073)3.24629545
95regulation of dendritic cell antigen processing and presentation (GO:0002604)3.24366411
96detection of biotic stimulus (GO:0009595)3.24326184
97transepithelial transport (GO:0070633)3.23851507
98fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.22746172
99pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.22013114
100sulfur amino acid catabolic process (GO:0000098)3.17855333
101hydrogen peroxide biosynthetic process (GO:0050665)3.17813009
102mature B cell differentiation involved in immune response (GO:0002313)3.17776235
103response to interferon-alpha (GO:0035455)3.16782776
104SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.16577805
105negative regulation of lymphocyte mediated immunity (GO:0002707)3.15976383
106secretory granule organization (GO:0033363)3.15532332
107purinergic nucleotide receptor signaling pathway (GO:0035590)3.15127696
108regulation of germinal center formation (GO:0002634)3.13186560
109pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.12754292
110phosphatidylglycerol biosynthetic process (GO:0006655)3.10440770
111triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.09929265
112cotranslational protein targeting to membrane (GO:0006613)3.09784684
113germinal center formation (GO:0002467)3.09373791
114negative regulation of interleukin-12 production (GO:0032695)3.09358176
115tryptophan metabolic process (GO:0006568)3.09331336
116protein targeting to ER (GO:0045047)3.07375727
117positive regulation of antigen processing and presentation (GO:0002579)3.04412071
118regulation of respiratory burst (GO:0060263)3.03829872
119regulation of regulatory T cell differentiation (GO:0045589)3.03553695
120imidazole-containing compound metabolic process (GO:0052803)3.03198068
121negative regulation of cell aging (GO:0090344)3.02518298
122lens fiber cell differentiation (GO:0070306)3.02476860
123negative regulation of innate immune response (GO:0045824)3.00319598
124respiratory chain complex IV assembly (GO:0008535)3.00172363
125protein localization to endoplasmic reticulum (GO:0070972)3.00047438
126semaphorin-plexin signaling pathway (GO:0071526)2.96916826
127nucleoside diphosphate metabolic process (GO:0009132)2.93771658
128amino-acid betaine metabolic process (GO:0006577)2.93178736
129positive regulation of interferon-alpha production (GO:0032727)2.92856604
130pyrimidine nucleoside biosynthetic process (GO:0046134)2.91792114
131antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.91776668
132antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91776668
133negative regulation of immunoglobulin mediated immune response (GO:0002890)2.91246810
134negative regulation of B cell mediated immunity (GO:0002713)2.91246810
135megakaryocyte development (GO:0035855)2.91146816
136establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90378936
137regulation of toll-like receptor signaling pathway (GO:0034121)2.90000320
138regulation of interleukin-6 biosynthetic process (GO:0045408)2.89851730
139interferon-gamma-mediated signaling pathway (GO:0060333)2.89678936
140pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.89300733
141regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.89116464
142purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.88958343
143regulation of cilium movement (GO:0003352)2.88379037
144positive regulation of T cell mediated cytotoxicity (GO:0001916)2.88358699
145pyrimidine ribonucleotide metabolic process (GO:0009218)2.87953737
146regulation of mast cell degranulation (GO:0043304)2.86961167
147aminoglycoside antibiotic metabolic process (GO:0030647)2.86608955
148myeloid cell activation involved in immune response (GO:0002275)2.86390144
149viral life cycle (GO:0019058)2.86145758
150reactive oxygen species biosynthetic process (GO:1903409)2.85952622
151glyoxylate metabolic process (GO:0046487)2.84214246
152negative regulation of tumor necrosis factor production (GO:0032720)2.83891120
153regulation of antigen processing and presentation (GO:0002577)2.83765092
154G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.82693076
155phosphatidylethanolamine biosynthetic process (GO:0006646)2.82254485
156alpha-linolenic acid metabolic process (GO:0036109)2.80630909
157regulation of interferon-alpha production (GO:0032647)2.80489781
158negative regulation of leukocyte mediated immunity (GO:0002704)2.79922118
159coenzyme catabolic process (GO:0009109)2.79445200
160pseudouridine synthesis (GO:0001522)2.79186924
161regulation of interferon-beta production (GO:0032648)2.78868032
162response to nitrosative stress (GO:0051409)2.78850448
163response to xenobiotic stimulus (GO:0009410)2.78571308
164regulation of gamma-delta T cell activation (GO:0046643)2.76401768
165regulation of type I interferon-mediated signaling pathway (GO:0060338)2.75819769
166negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.75640562
167endosome to pigment granule transport (GO:0043485)2.75201473
168endosome to melanosome transport (GO:0035646)2.75201473
169lipoxygenase pathway (GO:0019372)2.73589016
170nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.73400825
171granulocyte differentiation (GO:0030851)2.72786299
172kynurenine metabolic process (GO:0070189)2.72727330
173regulation of myeloid leukocyte mediated immunity (GO:0002886)2.72282652
174regulation of cholesterol esterification (GO:0010872)2.72191070
175heparin biosynthetic process (GO:0030210)2.70844598
176heparin metabolic process (GO:0030202)2.70844598
177NAD biosynthetic process (GO:0009435)2.69732955
178purinergic receptor signaling pathway (GO:0035587)2.69679691
179left/right pattern formation (GO:0060972)2.68726448
180cellular protein complex disassembly (GO:0043624)2.68676086
181AMP metabolic process (GO:0046033)2.67700198
182macrophage activation (GO:0042116)2.65782902
183leukocyte aggregation (GO:0070486)2.65193291
184primary alcohol catabolic process (GO:0034310)2.64444374
185cellular response to thyroid hormone stimulus (GO:0097067)2.61296855
186nitrogen cycle metabolic process (GO:0071941)2.59976171
187positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59277283
188respiratory burst (GO:0045730)2.59165325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.72900918
2SCL_19346495_ChIP-Seq_HPC-7_Human5.25704741
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.26258799
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.04969681
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.36149708
6GATA1_22025678_ChIP-Seq_K562_Human3.25486628
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.14044288
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.13165125
9RBPJ_22232070_ChIP-Seq_NCS_Mouse3.12436978
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.10629096
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.06055216
12LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.00965285
13NOTCH1_21737748_ChIP-Seq_TLL_Human3.00080792
14LXR_22292898_ChIP-Seq_THP-1_Human2.98942013
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.91233618
16P68_20966046_ChIP-Seq_HELA_Human2.58196205
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.45681985
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44924916
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.39625731
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.39605442
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.34677340
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30664512
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23160148
24RACK7_27058665_Chip-Seq_MCF-7_Human2.22320364
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.22027750
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.21933101
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.20669667
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.20330488
29KDM2B_26808549_Chip-Seq_SUP-B15_Human2.19950827
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14742200
31GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.09913495
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08413840
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06122143
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.01522804
35E2F1_20622854_ChIP-Seq_HELA_Human2.00877300
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.98906575
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96963361
38UTX_26944678_Chip-Seq_JUKART_Human1.96464481
39* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.94520743
40CTCF_27219007_Chip-Seq_ERYTHROID_Human1.87317313
41SMC4_20622854_ChIP-Seq_HELA_Human1.87284694
42KDM2B_26808549_Chip-Seq_DND41_Human1.86887090
43SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.85090170
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.85050946
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82828070
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82790501
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.79642513
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79421813
49PHF8_20622854_ChIP-Seq_HELA_Human1.78911585
50TCF7_22412390_ChIP-Seq_EML_Mouse1.77413640
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.77214176
52MYC_22102868_ChIP-Seq_BL_Human1.73855335
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.67861487
54YY1_22570637_ChIP-Seq_MALME-3M_Human1.64380641
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.64186751
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63806034
57CTCF_27219007_Chip-Seq_Bcells_Human1.62118633
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.60279360
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58036456
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57336793
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56913057
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.55705801
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55666509
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.54997359
65CTCF_20526341_ChIP-Seq_ESCs_Human1.52835649
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52097801
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.51483701
68* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50089158
69CREB1_26743006_Chip-Seq_LNCaP_Human1.49763209
70SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49158993
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49117122
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47127894
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.46848554
74SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44785190
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43711108
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43647286
77CTCF_21964334_Chip-Seq_Bcells_Human1.43349078
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42200160
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.41243446
80MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.40757764
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.38981987
82SA1_27219007_Chip-Seq_Bcells_Human1.37646678
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37177391
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36883020
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36467944
86CTCF_21964334_ChIP-Seq_BJAB-B_Human1.35113640
87TP53_22127205_ChIP-Seq_IMR90_Human1.34753289
88ERG_20517297_ChIP-Seq_VCAP_Human1.34245379
89IRF8_27001747_Chip-Seq_BMDM_Mouse1.33590462
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31198316
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30728838
92* RARA_24833708_ChIP-Seq_LIVER_Mouse1.30304052
93NANOG_20526341_ChIP-Seq_ESCs_Human1.30207733
94* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30173839
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.29845160
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29843427
97SOX2_22085726_ChIP-Seq_NPCs_Mouse1.29588828
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29547027
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29125209
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29052807
101RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28728155
102EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26206267
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24550983
104STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24113336
105HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23716349
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21554922
107EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21239291
108TP63_22573176_ChIP-Seq_HFKS_Human1.21116141
109* MAF_26560356_Chip-Seq_TH1_Human1.20950259
110P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20829697
111NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20792465
112BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.20392607
113AR_20517297_ChIP-Seq_VCAP_Human1.19888210
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19652923
115KAP1_22055183_ChIP-Seq_ESCs_Mouse1.18066160
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15888115
117* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15061066
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14360991
119DROSHA_22980978_ChIP-Seq_HELA_Human1.14136275
120MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13756942
121NCOR1_26117541_ChIP-Seq_K562_Human1.13686112
122RUNX1_22412390_ChIP-Seq_EML_Mouse1.13554952
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13447320
124KDM2B_26808549_Chip-Seq_JURKAT_Human1.13353498
125DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12279704
126MYC_18555785_ChIP-Seq_MESCs_Mouse1.11866349
127CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08372995
128BCL6_27268052_Chip-Seq_Bcells_Human1.07986793
129MYB_26560356_Chip-Seq_TH1_Human1.07941696
130GATA2_21666600_ChIP-Seq_HMVEC_Human1.07317486
131STAT1_20625510_ChIP-Seq_HELA_Human1.06515787
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06002704
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05745478
134VDR_24763502_ChIP-Seq_THP-1_Human1.05130739
135SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03310738
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02557278
137LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02543525
138SPI1_23547873_ChIP-Seq_NB4_Human1.01833797
139* VDR_21846776_ChIP-Seq_THP-1_Human0.99959685
140P53_21459846_ChIP-Seq_SAOS-2_Human0.98883933
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98809511
142SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98506580
143GATA1_19941826_ChIP-Seq_K562_Human0.97828337
144HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96864165
145CTCF_26484167_Chip-Seq_Bcells_Mouse0.95519922
146RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95299441
147* MYB_26560356_Chip-Seq_TH2_Human0.94210864
148P300_27268052_Chip-Seq_Bcells_Human0.93793318
149TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93263244
150THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92659891
151* GATA3_21867929_ChIP-Seq_CD8_Mouse0.90312045
152STAT1_17558387_ChIP-Seq_HELA_Human0.89928342
153VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89757869
154CEBPB_22108803_ChIP-Seq_LS180_Human0.89441102
155FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.88814596
156ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88246461
157PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87574214
158STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.87166796
159GATA2_19941826_ChIP-Seq_K562_Human0.85566311
160FOXP3_21729870_ChIP-Seq_TREG_Human0.85357851
161GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83973654
162BCOR_27268052_Chip-Seq_Bcells_Human0.83853501
163SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83763837
164HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82482023
165SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81519704
166TAF2_19829295_ChIP-Seq_ESCs_Human0.80894498
167NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80041790
168MAF_26560356_Chip-Seq_TH2_Human0.79838441
169* RARB_24833708_ChIP-Seq_LIVER_Mouse0.79491593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.65056757
2MP0005360_urolithiasis4.20672132
3MP0005085_abnormal_gallbladder_physiolo4.06879658
4MP0005365_abnormal_bile_salt3.93990465
5MP0008875_abnormal_xenobiotic_pharmacok3.86622255
6MP0003303_peritoneal_inflammation3.68429279
7MP0003136_yellow_coat_color3.27606300
8MP0005171_absent_coat_pigmentation3.25062025
9MP0006082_CNS_inflammation2.78648125
10MP0003806_abnormal_nucleotide_metabolis2.67809712
11MP0009697_abnormal_copulation2.64113684
12MP0005075_abnormal_melanosome_morpholog2.58589370
13MP0009379_abnormal_foot_pigmentation2.54931596
14MP0004147_increased_porphyrin_level2.51849587
15MP0002396_abnormal_hematopoietic_system2.41813848
16MP0010329_abnormal_lipoprotein_level2.34173888
17MP0005387_immune_system_phenotype2.33404753
18MP0003724_increased_susceptibility_to2.28970608
19MP0005058_abnormal_lysosome_morphology2.26998856
20MP0003453_abnormal_keratinocyte_physiol2.12780750
21MP0003252_abnormal_bile_duct2.12302699
22MP0005174_abnormal_tail_pigmentation2.11650107
23MP0000685_abnormal_immune_system2.07461567
24MP0005464_abnormal_platelet_physiology2.02007810
25MP0004808_abnormal_hematopoietic_stem2.00277002
26MP0003011_delayed_dark_adaptation1.95990544
27MP0003172_abnormal_lysosome_physiology1.92150129
28MP0001764_abnormal_homeostasis1.85739497
29MP0001666_abnormal_nutrient_absorption1.82913672
30MP0005000_abnormal_immune_tolerance1.80412212
31MP0001545_abnormal_hematopoietic_system1.79067202
32MP0005397_hematopoietic_system_phenotyp1.79067202
33MP0002277_abnormal_respiratory_mucosa1.79042121
34MP0003878_abnormal_ear_physiology1.67306551
35MP0005377_hearing/vestibular/ear_phenot1.67306551
36MP0001873_stomach_inflammation1.66913011
37MP0002095_abnormal_skin_pigmentation1.65861984
38MP0009785_altered_susceptibility_to1.61225098
39MP0009278_abnormal_bone_marrow1.60975001
40MP0002132_abnormal_respiratory_system1.59985267
41MP0003656_abnormal_erythrocyte_physiolo1.55113081
42MP0002254_reproductive_system_inflammat1.55046650
43MP0003868_abnormal_feces_composition1.55046240
44MP0003943_abnormal_hepatobiliary_system1.54874296
45MP0005423_abnormal_somatic_nervous1.53543390
46MP0005409_darkened_coat_color1.53457003
47MP0003191_abnormal_cellular_cholesterol1.53071461
48MP0000751_myopathy1.48561908
49MP0003866_abnormal_defecation1.44062082
50MP0004947_skin_inflammation1.42562631
51MP0005319_abnormal_enzyme/_coenzyme1.42372892
52MP0001533_abnormal_skeleton_physiology1.42285001
53MP0008004_abnormal_stomach_pH1.40250182
54MP0000858_altered_metastatic_potential1.39619968
55MP0004019_abnormal_vitamin_homeostasis1.38392940
56MP0004381_abnormal_hair_follicle1.38374798
57MP0001986_abnormal_taste_sensitivity1.37332963
58MP0005330_cardiomyopathy1.37285389
59MP0001835_abnormal_antigen_presentation1.37167352
60MP0005332_abnormal_amino_acid1.36767209
61MP0006054_spinal_hemorrhage1.36671152
62MP0005025_abnormal_response_to1.36561084
63MP0000465_gastrointestinal_hemorrhage1.34526097
64MP0001853_heart_inflammation1.33938224
65MP0005410_abnormal_fertilization1.33156958
66MP0002653_abnormal_ependyma_morphology1.31556584
67MP0003763_abnormal_thymus_physiology1.30729653
68MP0006036_abnormal_mitochondrial_physio1.30311246
69MP0002249_abnormal_larynx_morphology1.29370277
70MP0004043_abnormal_pH_regulation1.29064368
71MP0009840_abnormal_foam_cell1.27589707
72MP0003186_abnormal_redox_activity1.25875280
73MP0004510_myositis1.25124947
74MP0010155_abnormal_intestine_physiology1.24926279
75MP0001756_abnormal_urination1.24679527
76MP0000609_abnormal_liver_physiology1.23528184
77MP0005083_abnormal_biliary_tract1.23344363
78MP0005584_abnormal_enzyme/coenzyme_acti1.23023934
79MP0001765_abnormal_ion_homeostasis1.22844021
80MP0005084_abnormal_gallbladder_morpholo1.21079481
81MP0005671_abnormal_response_to1.20270144
82MP0003448_altered_tumor_morphology1.20074531
83MP0002928_abnormal_bile_duct1.19113835
84MP0002118_abnormal_lipid_homeostasis1.16697462
85MP0008469_abnormal_protein_level1.16492532
86MP0006292_abnormal_olfactory_placode1.13420842
87MP0001663_abnormal_digestive_system1.12491716
88MP0008995_early_reproductive_senescence1.10346319
89MP0009333_abnormal_splenocyte_physiolog1.09317833
90MP0010368_abnormal_lymphatic_system1.07704750
91MP0000750_abnormal_muscle_regeneration1.07633560
92MP0003436_decreased_susceptibility_to1.07400864
93MP0002933_joint_inflammation1.06521987
94MP0005310_abnormal_salivary_gland1.06310868
95MP0005076_abnormal_cell_differentiation1.03815742
96MP0004130_abnormal_muscle_cell1.02502104
97MP0005636_abnormal_mineral_homeostasis1.02090784
98MP0005166_decreased_susceptibility_to1.01276542
99MP0001188_hyperpigmentation1.00285079
100MP0009763_increased_sensitivity_to0.99479506
101MP0000689_abnormal_spleen_morphology0.97420105
102MP0009765_abnormal_xenobiotic_induced0.97378396
103MP0009643_abnormal_urine_homeostasis0.95853859
104MP0001800_abnormal_humoral_immune0.95541519
105MP0000598_abnormal_liver_morphology0.95484905
106MP0001661_extended_life_span0.95098001
107MP0003300_gastrointestinal_ulcer0.94577831
108MP0001502_abnormal_circadian_rhythm0.94268963
109MP0009764_decreased_sensitivity_to0.93765599
110MP0001958_emphysema0.93127903
111MP0000490_abnormal_crypts_of0.92282909
112MP0002398_abnormal_bone_marrow0.92027314
113MP0002723_abnormal_immune_serum0.90920122
114MP0005023_abnormal_wound_healing0.90609117
115MP0005647_abnormal_sex_gland0.90164926
116MP0002722_abnormal_immune_system0.90003628
117MP0003705_abnormal_hypodermis_morpholog0.89446019
118MP0002998_abnormal_bone_remodeling0.88870393
119MP0001845_abnormal_inflammatory_respons0.88606153
120MP0002405_respiratory_system_inflammati0.87795354
121MP0002160_abnormal_reproductive_system0.87679800
122MP0000015_abnormal_ear_pigmentation0.84372636
123MP0004782_abnormal_surfactant_physiolog0.84102416
124MP0008260_abnormal_autophagy0.83366598
125MP0002148_abnormal_hypersensitivity_rea0.83275273
126MP0002136_abnormal_kidney_physiology0.83021112
127MP0003638_abnormal_response/metabolism_0.82556471
128MP0001879_abnormal_lymphatic_vessel0.81701559
129MP0003091_abnormal_cell_migration0.81580422
130MP0009642_abnormal_blood_homeostasis0.80655829
131MP0002429_abnormal_blood_cell0.80219782
132MP0000470_abnormal_stomach_morphology0.79594606
133MP0000716_abnormal_immune_system0.79133643
134MP0001664_abnormal_digestion0.77884063
135MP0005646_abnormal_pituitary_gland0.77861793
136MP0003075_altered_response_to0.76523988
137MP0002419_abnormal_innate_immunity0.76476887
138MP0002452_abnormal_antigen_presenting0.76188068
139MP0005167_abnormal_blood-brain_barrier0.76132384
140MP0002420_abnormal_adaptive_immunity0.76060245
141MP0001819_abnormal_immune_cell0.73367768
142MP0000747_muscle_weakness0.72642637
143MP0001929_abnormal_gametogenesis0.72609516
144MP0000343_altered_response_to0.71715622
145MP0004883_abnormal_blood_vessel0.70165464
146MP0002166_altered_tumor_susceptibility0.69057925
147MP0003698_abnormal_male_reproductive0.68854158
148MP0001790_abnormal_immune_system0.65154366

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.25006023
2Abnormal respiratory motile cilium physiology (HP:0012261)7.87421997
3Abnormal ciliary motility (HP:0012262)7.66187175
4Rhinitis (HP:0012384)7.01655002
5Abnormal respiratory epithelium morphology (HP:0012253)6.32404378
6Abnormal respiratory motile cilium morphology (HP:0005938)6.32404378
7Dynein arm defect of respiratory motile cilia (HP:0012255)5.42744722
8Absent/shortened dynein arms (HP:0200106)5.42744722
9Nasal polyposis (HP:0100582)4.91582409
10Abnormality of the nasal mucosa (HP:0000433)4.80846572
11Chronic bronchitis (HP:0004469)4.73591911
12Bronchiectasis (HP:0002110)4.58420453
13Dyschromatopsia (HP:0007641)4.41852396
14Hemorrhage of the eye (HP:0011885)4.30098935
15Testicular atrophy (HP:0000029)4.29567752
16Mesangial abnormality (HP:0001966)4.01696863
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.56383045
18Rib fusion (HP:0000902)3.50086884
19Thin bony cortex (HP:0002753)3.43531529
20Bronchitis (HP:0012387)3.28906598
21Choroideremia (HP:0001139)3.26549397
22Chronic sinusitis (HP:0011109)3.24587938
23Popliteal pterygium (HP:0009756)3.23507106
24True hermaphroditism (HP:0010459)3.18528443
25Chronic hepatic failure (HP:0100626)3.17116690
26Intrahepatic cholestasis (HP:0001406)3.16796464
27Pancreatic fibrosis (HP:0100732)3.16001435
28Attenuation of retinal blood vessels (HP:0007843)3.15920437
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.09473238
30Aplastic anemia (HP:0001915)3.04722995
31Facial diplegia (HP:0001349)3.02871516
32Decreased central vision (HP:0007663)3.01348645
33Eczematoid dermatitis (HP:0000976)2.98229406
34Recurrent sinusitis (HP:0011108)2.93255605
35Fetal akinesia sequence (HP:0001989)2.90801439
36Thrombocytosis (HP:0001894)2.89851360
37Molar tooth sign on MRI (HP:0002419)2.85997503
38Abnormality of midbrain morphology (HP:0002418)2.85997503
39Abnormal number of erythroid precursors (HP:0012131)2.85804889
40Prolonged partial thromboplastin time (HP:0003645)2.84755164
41Male infertility (HP:0003251)2.84748816
42Aplasia of the musculature (HP:0100854)2.84625340
43Abnormality of cells of the erythroid lineage (HP:0012130)2.82757633
44Prolonged bleeding time (HP:0003010)2.78815633
45Annular pancreas (HP:0001734)2.77862169
46Pancreatic cysts (HP:0001737)2.77620521
47Akinesia (HP:0002304)2.77175899
48Myositis (HP:0100614)2.77084261
49Recurrent abscess formation (HP:0002722)2.74385924
50Recurrent bacterial skin infections (HP:0005406)2.72307640
51Abnormality of the heme biosynthetic pathway (HP:0010472)2.68300773
52Malnutrition (HP:0004395)2.66644353
53Abnormality of monocarboxylic acid metabolism (HP:0010996)2.65625903
54Spontaneous abortion (HP:0005268)2.64010709
55Hypobetalipoproteinemia (HP:0003563)2.60315414
56Vaginal fistula (HP:0004320)2.58999911
57Epistaxis (HP:0000421)2.56477569
58Abnormality of macrophages (HP:0004311)2.53028629
59Bile duct proliferation (HP:0001408)2.52825791
60Abnormal biliary tract physiology (HP:0012439)2.52825791
61Ulnar bowing (HP:0003031)2.52261610
62Tubulointerstitial nephritis (HP:0001970)2.46080027
63Recurrent gram-negative bacterial infections (HP:0005420)2.46032484
64Gastrointestinal infarctions (HP:0005244)2.45959524
65Decreased electroretinogram (ERG) amplitude (HP:0000654)2.44989150
66Rectovaginal fistula (HP:0000143)2.44451594
67Rectal fistula (HP:0100590)2.44451594
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.44234975
69Abnormality of polysaccharide metabolism (HP:0011012)2.44234975
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.44234975
71Renal Fanconi syndrome (HP:0001994)2.43929478
72Median cleft lip (HP:0000161)2.42886432
73Petechiae (HP:0000967)2.38826214
74Poikiloderma (HP:0001029)2.37339151
75Intestinal fistula (HP:0100819)2.35442693
76Oral leukoplakia (HP:0002745)2.35432006
77Increased hepatocellular lipid droplets (HP:0006565)2.34576351
78Recurrent bronchitis (HP:0002837)2.32449724
79Abnormal albumin level (HP:0012116)2.30626892
80Hypoalbuminemia (HP:0003073)2.30626892
81Reduced antithrombin III activity (HP:0001976)2.29212048
82Atrioventricular block (HP:0001678)2.29047796
83Mucopolysacchariduria (HP:0008155)2.28814877
84Urinary glycosaminoglycan excretion (HP:0003541)2.28814877
85Atelectasis (HP:0100750)2.28412374
86Infertility (HP:0000789)2.27054944
87Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26043229
88Orchitis (HP:0100796)2.26038764
89Chronic mucocutaneous candidiasis (HP:0002728)2.23466291
90Recurrent cutaneous fungal infections (HP:0011370)2.23466291
91IgM deficiency (HP:0002850)2.23249541
92Neoplasm of head and neck (HP:0012288)2.21411588
93Esophageal neoplasm (HP:0100751)2.21411588
94Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21096030
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21096030
96Purpura (HP:0000979)2.20461804
97Xanthomatosis (HP:0000991)2.20070905
98Joint hemorrhage (HP:0005261)2.19030460
99Zonular cataract (HP:0010920)2.18511585
100Abnormality of the costochondral junction (HP:0000919)2.17227448
101Congenital hepatic fibrosis (HP:0002612)2.16950086
102Lipid accumulation in hepatocytes (HP:0006561)2.16572436
103Impaired platelet aggregation (HP:0003540)2.16424736
104Abnormal platelet function (HP:0011869)2.16424736
105Joint stiffness (HP:0001387)2.15650310
106Menorrhagia (HP:0000132)2.14690078
107Gingival bleeding (HP:0000225)2.14686922
108Supernumerary spleens (HP:0009799)2.14521159
109Occipital encephalocele (HP:0002085)2.12253368
110Recurrent otitis media (HP:0000403)2.11993409
111Pancytopenia (HP:0001876)2.10983618
112Deep venous thrombosis (HP:0002625)2.08697425
113Delayed epiphyseal ossification (HP:0002663)2.07788969
114Recurrent skin infections (HP:0001581)2.06645672
115Retrobulbar optic neuritis (HP:0100654)2.06488656
116Optic neuritis (HP:0100653)2.06488656
117Nephronophthisis (HP:0000090)2.05526855
118Turricephaly (HP:0000262)2.04845259
119Exertional dyspnea (HP:0002875)2.04406863
120Ketosis (HP:0001946)2.03974663
121Cystic liver disease (HP:0006706)2.03451960
122Bony spicule pigmentary retinopathy (HP:0007737)2.00812785
123Recurrent fungal infections (HP:0002841)2.00666556
124Hyperbilirubinemia (HP:0002904)1.98327283
125Hyperammonemia (HP:0001987)1.97603766
126Widely patent fontanelles and sutures (HP:0004492)1.97215425
127Hyperglycinemia (HP:0002154)1.97058391
128Hyperlipoproteinemia (HP:0010980)1.96869028
129Microcytic anemia (HP:0001935)1.96449851
130Cheilitis (HP:0100825)1.94392401
131Reticulocytopenia (HP:0001896)1.94353102
132Macular degeneration (HP:0000608)1.92696110
133Increased muscle lipid content (HP:0009058)1.91998965
134Type II lissencephaly (HP:0007260)1.91441984
135Colitis (HP:0002583)1.91128447
136Facial hemangioma (HP:0000329)1.89629860
137Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.89352352
138Respiratory difficulties (HP:0002880)1.89174135
139Abnormality of the intrinsic pathway (HP:0010989)1.88270159
140Fat malabsorption (HP:0002630)1.87138563
141Abnormality of glycine metabolism (HP:0010895)1.86495285
142Abnormality of serine family amino acid metabolism (HP:0010894)1.86495285
143Obstructive lung disease (HP:0006536)1.86308065
144Chronic obstructive pulmonary disease (HP:0006510)1.86308065
145Systemic lupus erythematosus (HP:0002725)1.85826467
14611 pairs of ribs (HP:0000878)1.84818452
147Decreased circulating renin level (HP:0003351)1.84816978
148Squamous cell carcinoma (HP:0002860)1.84490575
149Elevated erythrocyte sedimentation rate (HP:0003565)1.82967285
150Conjugated hyperbilirubinemia (HP:0002908)1.81322211
151Dysostosis multiplex (HP:0000943)1.81206140
152Abnormality of the common coagulation pathway (HP:0010990)1.80527842
153Abnormality of the axillary hair (HP:0100134)1.79007368
154Abnormality of secondary sexual hair (HP:0009888)1.79007368
155Dicarboxylic aciduria (HP:0003215)1.78440072
156Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78440072
157Hyperglycinuria (HP:0003108)1.77357100
158Enlarged epiphyses (HP:0010580)1.76109399
159Abnormality of pyrimidine metabolism (HP:0004353)1.75758874
160Postaxial foot polydactyly (HP:0001830)1.75253237
161Hepatic necrosis (HP:0002605)1.74662265
162Delayed CNS myelination (HP:0002188)1.71630695
163Hepatocellular necrosis (HP:0001404)1.71518201
164Chronic otitis media (HP:0000389)1.69211877
165Abnormality of glutamine family amino acid metabolism (HP:0010902)1.69197645
166Portal hypertension (HP:0001409)1.68496509
167Asplenia (HP:0001746)1.68253671
168Acute myeloid leukemia (HP:0004808)1.67387198
169Metabolic acidosis (HP:0001942)1.67300654
170Abnormal spermatogenesis (HP:0008669)1.66300989
171Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.65852978
172Increased intramyocellular lipid droplets (HP:0012240)1.63471755
173Hypolipoproteinemia (HP:0010981)1.62631003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.71067721
2MUSK3.78861864
3BLK3.43567173
4STK163.17418699
5RIPK42.81679367
6CSK2.64558183
7TGFBR12.55346166
8BCKDK2.53729508
9KIT2.53422299
10PIK3CG2.51224719
11FLT32.44220592
12WEE12.28872779
13TNIK2.23255015
14VRK12.17176819
15TGFBR22.14548871
16PIM22.08877007
17TEC1.96406175
18TIE11.94171987
19TYK21.86891799
20BTK1.76743670
21MAP3K31.71956656
22MAP2K61.71006802
23NLK1.68656497
24MAP2K31.66552431
25CAMKK21.66480049
26TRIB31.64943835
27PRKG21.64674895
28TLK11.63258963
29NME21.62133947
30MAPKAPK51.57240395
31MAP3K121.46868129
32MAP4K11.44623448
33MATK1.43644535
34MAP2K71.40392237
35EPHA21.36028838
36EEF2K1.34939059
37ADRBK21.34398268
38CDK81.30096969
39MAP3K111.27041941
40TNK21.25649347
41GRK11.24346221
42CSF1R1.24183690
43WNK41.23682068
44CDK191.22616381
45SIK21.21208000
46PDPK11.19301634
47MAP3K141.18176763
48RPS6KB21.15776006
49SIK11.14971695
50DYRK31.14963649
51JAK31.13264238
52ACVR1B1.12943625
53BRSK21.11148435
54TESK21.11133666
55SMG11.07689503
56IRAK11.06768940
57MAP2K21.06662984
58PRKD21.05640716
59KDR1.05120652
60IRAK31.04902315
61TAOK11.03208517
62PNCK1.00972421
63PRPF4B0.99751514
64FES0.99090860
65MAP3K100.96151013
66LRRK20.95457451
67MYLK0.95428496
68MARK20.95334460
69MKNK10.90007639
70CDC42BPA0.89834207
71SIK30.87547578
72PINK10.87348652
73TAOK30.86063343
74DYRK1B0.85462626
75CSNK1G10.82727974
76IRAK20.82365342
77BMX0.79548122
78PAK20.79463397
79MAP3K10.79435236
80HCK0.77899906
81TBK10.77813212
82CAMK10.77388067
83MAP3K130.75680807
84FGR0.75104017
85RIPK10.74570343
86ERN10.74097504
87EPHA30.71787955
88MAP3K60.71011565
89MAPK40.68310237
90JAK10.66190457
91FGFR40.64912999
92PTK60.61983349
93SYK0.60967088
94PRKD10.58794897
95IKBKE0.58670517
96MST1R0.58445785
97CSNK1G30.57573071
98RPS6KA20.57153959
99LCK0.56303334
100JAK20.55931828
101ADRBK10.55456231
102NEK90.55371201
103CDK60.55191359
104LYN0.55020902
105TAOK20.54773183
106GRK60.53283282
107PDK10.52430526
108IRAK40.52100832
109CCNB10.51851210
110IKBKB0.51698538
111PDK30.51010952
112PDK40.51010952
113PAK10.50479099
114CDK30.50103366
115STK100.49888162
116MAP2K40.49742224
117TXK0.49577671
118MAPK110.48015026
119RPS6KA50.47289366
120MKNK20.46120111
121ARAF0.45535484
122MAP3K20.44890716
123EPHB10.44559778
124PRKCD0.43966628
125MAPKAPK30.43621205
126CDK40.43021462
127YES10.42736707
128CHUK0.42681034
129MAPK70.42337942
130MAPK120.41535068
131RPS6KA60.41504686
132STK110.41480151
133PTK2B0.41114794
134MST40.40713616
135HIPK20.40118902
136STK380.39670275
137ICK0.39498499
138RPS6KL10.38326246
139RPS6KC10.38326246
140PRKCQ0.36341752
141MAP3K70.35686881
142NEK20.35608431
143GRK70.35232889
144MAPK30.34840184
145PIM10.34496136
146PRKAA20.34341972
147SRPK10.34323721
148ZAP700.33718379
149FYN0.33169587
150DAPK10.30510058
151CASK0.30253785
152MARK30.29520563
153ATR0.28881426
154NME10.28792508
155RAF10.27143579
156LMTK20.26329524

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.77412867
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.43973175
3Ribosome_Homo sapiens_hsa030103.21476061
4Caffeine metabolism_Homo sapiens_hsa002322.94522285
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.94039786
6Nitrogen metabolism_Homo sapiens_hsa009102.75126897
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51600670
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.45811717
9Other glycan degradation_Homo sapiens_hsa005112.42766827
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.35725449
11Leishmaniasis_Homo sapiens_hsa051402.16724813
12Allograft rejection_Homo sapiens_hsa053302.13704784
13Tryptophan metabolism_Homo sapiens_hsa003802.12097278
14Osteoclast differentiation_Homo sapiens_hsa043802.05264439
15Complement and coagulation cascades_Homo sapiens_hsa046102.03006038
16Histidine metabolism_Homo sapiens_hsa003402.01811147
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.01228487
18Fatty acid degradation_Homo sapiens_hsa000712.00959246
19Graft-versus-host disease_Homo sapiens_hsa053321.98193051
20DNA replication_Homo sapiens_hsa030301.94687388
21Folate biosynthesis_Homo sapiens_hsa007901.89113548
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88679650
23Autoimmune thyroid disease_Homo sapiens_hsa053201.88356600
24Peroxisome_Homo sapiens_hsa041461.86376314
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.85758746
26Mismatch repair_Homo sapiens_hsa034301.82610546
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.78797147
28Pyrimidine metabolism_Homo sapiens_hsa002401.78643364
29Chemical carcinogenesis_Homo sapiens_hsa052041.77791010
30Sphingolipid metabolism_Homo sapiens_hsa006001.76746699
31Tuberculosis_Homo sapiens_hsa051521.70458407
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70382295
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68698784
34Sulfur relay system_Homo sapiens_hsa041221.68679201
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.68667048
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.65378214
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65007044
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65000358
39Lysosome_Homo sapiens_hsa041421.63895634
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63429891
41Arginine biosynthesis_Homo sapiens_hsa002201.63316586
42Propanoate metabolism_Homo sapiens_hsa006401.59929929
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59123250
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.57136495
45PPAR signaling pathway_Homo sapiens_hsa033201.56829371
46Retinol metabolism_Homo sapiens_hsa008301.54430956
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53823725
48Fructose and mannose metabolism_Homo sapiens_hsa000511.53152411
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50538860
50Asthma_Homo sapiens_hsa053101.50167639
51Type I diabetes mellitus_Homo sapiens_hsa049401.46864971
52Fatty acid elongation_Homo sapiens_hsa000621.45558574
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42261519
54beta-Alanine metabolism_Homo sapiens_hsa004101.41670558
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38283700
56Butanoate metabolism_Homo sapiens_hsa006501.28799795
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.28398903
58Malaria_Homo sapiens_hsa051441.27751392
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27437723
60Influenza A_Homo sapiens_hsa051641.27105059
61Hepatitis C_Homo sapiens_hsa051601.25239419
62NF-kappa B signaling pathway_Homo sapiens_hsa040641.24100485
63Pertussis_Homo sapiens_hsa051331.23378338
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19708067
65Toxoplasmosis_Homo sapiens_hsa051451.19561283
66ABC transporters_Homo sapiens_hsa020101.18117082
67Pentose phosphate pathway_Homo sapiens_hsa000301.17595846
68Pyruvate metabolism_Homo sapiens_hsa006201.15731592
69Purine metabolism_Homo sapiens_hsa002301.13576075
70Nucleotide excision repair_Homo sapiens_hsa034201.12795146
71TNF signaling pathway_Homo sapiens_hsa046681.10791906
72Starch and sucrose metabolism_Homo sapiens_hsa005001.10380880
73Homologous recombination_Homo sapiens_hsa034401.06954252
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05995028
75Vitamin digestion and absorption_Homo sapiens_hsa049771.04870183
76Selenocompound metabolism_Homo sapiens_hsa004501.03786704
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03541785
78Glutathione metabolism_Homo sapiens_hsa004801.03261337
79Herpes simplex infection_Homo sapiens_hsa051681.03166339
80Rheumatoid arthritis_Homo sapiens_hsa053231.03012564
81Sulfur metabolism_Homo sapiens_hsa009200.99013711
82Fatty acid metabolism_Homo sapiens_hsa012120.98618228
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98106187
84Measles_Homo sapiens_hsa051620.97749952
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97357935
86Base excision repair_Homo sapiens_hsa034100.97219402
87Phagosome_Homo sapiens_hsa041450.94037425
88Staphylococcus aureus infection_Homo sapiens_hsa051500.93548859
89Bile secretion_Homo sapiens_hsa049760.91487618
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91059526
91Notch signaling pathway_Homo sapiens_hsa043300.90640128
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90464453
93Viral myocarditis_Homo sapiens_hsa054160.89417335
94Chemokine signaling pathway_Homo sapiens_hsa040620.89127970
95Legionellosis_Homo sapiens_hsa051340.84144471
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.83454545
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82274784
98Galactose metabolism_Homo sapiens_hsa000520.82102259
99Fat digestion and absorption_Homo sapiens_hsa049750.81486566
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.80579172
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79372932
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79150653
103Biosynthesis of amino acids_Homo sapiens_hsa012300.78059740
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76037445
105Metabolic pathways_Homo sapiens_hsa011000.76021688
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75551658
107Salmonella infection_Homo sapiens_hsa051320.73830881
108Endocytosis_Homo sapiens_hsa041440.73651602
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.71812397
110Carbon metabolism_Homo sapiens_hsa012000.71339403
111One carbon pool by folate_Homo sapiens_hsa006700.70470374
112VEGF signaling pathway_Homo sapiens_hsa043700.70238956
113African trypanosomiasis_Homo sapiens_hsa051430.69064142
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.68527477
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67281356
116Apoptosis_Homo sapiens_hsa042100.62654086
117Arginine and proline metabolism_Homo sapiens_hsa003300.62326087
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62178055
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61735031
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.61482299
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.61335423
122Insulin resistance_Homo sapiens_hsa049310.60645231
123mTOR signaling pathway_Homo sapiens_hsa041500.59048904
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57435700
125Primary immunodeficiency_Homo sapiens_hsa053400.55266912
126T cell receptor signaling pathway_Homo sapiens_hsa046600.55192616
127Ovarian steroidogenesis_Homo sapiens_hsa049130.55047618
128Arachidonic acid metabolism_Homo sapiens_hsa005900.53312741
129Huntingtons disease_Homo sapiens_hsa050160.52801963
130Circadian rhythm_Homo sapiens_hsa047100.52600876
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50460544
132Vitamin B6 metabolism_Homo sapiens_hsa007500.49533101
133Inositol phosphate metabolism_Homo sapiens_hsa005620.49178613
134Tyrosine metabolism_Homo sapiens_hsa003500.48136726
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.47505545
136Hepatitis B_Homo sapiens_hsa051610.47161396
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46114579
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45077977
139Bladder cancer_Homo sapiens_hsa052190.44969797
140Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44745363
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43547385
142RNA degradation_Homo sapiens_hsa030180.42039261
143Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41883925
144B cell receptor signaling pathway_Homo sapiens_hsa046620.40720893
145SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40411190
146Phenylalanine metabolism_Homo sapiens_hsa003600.39671074
1472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38916457
148Fanconi anemia pathway_Homo sapiens_hsa034600.37397123
149Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36983832
150Platelet activation_Homo sapiens_hsa046110.36637582
151Hematopoietic cell lineage_Homo sapiens_hsa046400.36286393
152Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35613000
153N-Glycan biosynthesis_Homo sapiens_hsa005100.35342207
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.34763424
155Antigen processing and presentation_Homo sapiens_hsa046120.34655447
156Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33172156
157Glycerolipid metabolism_Homo sapiens_hsa005610.32988486
158Amoebiasis_Homo sapiens_hsa051460.32692117
159Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27806834
160Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27350277
161RNA polymerase_Homo sapiens_hsa030200.27040300
162alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26680156
163Systemic lupus erythematosus_Homo sapiens_hsa053220.26397667
164Linoleic acid metabolism_Homo sapiens_hsa005910.25409628
165Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24102328
166Acute myeloid leukemia_Homo sapiens_hsa052210.23983016
167Olfactory transduction_Homo sapiens_hsa047400.23389000

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