ODF3L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.93383127
2plasma membrane fusion (GO:0045026)9.69589968
3spermatid development (GO:0007286)9.52432438
4motile cilium assembly (GO:0044458)9.13313233
5cilium movement (GO:0003341)9.09519649
6reproduction (GO:0000003)8.93020332
7regulation of cilium movement (GO:0003352)8.91025402
8sperm capacitation (GO:0048240)7.75873390
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.42715062
10single fertilization (GO:0007338)7.29357354
11negative regulation of inclusion body assembly (GO:0090084)6.91834790
12piRNA metabolic process (GO:0034587)6.87220805
13synaptonemal complex organization (GO:0070193)6.81654984
14organic cation transport (GO:0015695)6.58644717
15synaptonemal complex assembly (GO:0007130)6.55712668
16male meiosis (GO:0007140)6.54685120
17spermatogenesis (GO:0007283)6.49592084
18male gamete generation (GO:0048232)6.46989461
19fertilization (GO:0009566)6.15097416
20positive regulation of odontogenesis (GO:0042482)6.04640145
21gamete generation (GO:0007276)5.93052881
22ventricular system development (GO:0021591)5.90691237
23artery smooth muscle contraction (GO:0014824)5.77776135
24microtubule depolymerization (GO:0007019)5.73057817
25regulation of inclusion body assembly (GO:0090083)5.69497135
26cellular response to ATP (GO:0071318)5.53260583
27calcium ion-dependent exocytosis (GO:0017156)5.31015866
28basement membrane organization (GO:0071711)5.29395488
29germ cell development (GO:0007281)5.24893230
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.22636504
31regulation of microtubule-based movement (GO:0060632)5.22505034
32tonic smooth muscle contraction (GO:0014820)5.16373591
33tooth mineralization (GO:0034505)5.02966319
34microtubule severing (GO:0051013)4.92598138
35histamine secretion (GO:0001821)4.90198186
36cell recognition (GO:0008037)4.80893540
37male meiosis I (GO:0007141)4.76142872
38multicellular organismal reproductive process (GO:0048609)4.68851756
39glycerol ether metabolic process (GO:0006662)4.67872461
40chromosome condensation (GO:0030261)4.60278126
41seminiferous tubule development (GO:0072520)4.50253612
42spermatid nucleus differentiation (GO:0007289)4.46584669
43left/right pattern formation (GO:0060972)4.43967024
44DNA packaging (GO:0006323)4.37557980
45lymph vessel development (GO:0001945)4.37381404
46chromosome organization involved in meiosis (GO:0070192)4.34332801
47ether metabolic process (GO:0018904)4.32804757
48negative regulation of receptor activity (GO:2000272)4.32443490
49DNA methylation involved in gamete generation (GO:0043046)4.26533780
50nucleoside diphosphate phosphorylation (GO:0006165)3.96763461
51chaperone-mediated protein complex assembly (GO:0051131)3.95954573
52intestinal epithelial cell development (GO:0060576)3.94264253
53regulation of apoptotic process involved in morphogenesis (GO:1902337)3.93061262
54meiotic nuclear division (GO:0007126)3.90653946
55sexual reproduction (GO:0019953)3.88301011
56amino-acid betaine transport (GO:0015838)3.85302978
57carnitine transport (GO:0015879)3.85302978
58maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.79071120
59carnitine transmembrane transport (GO:1902603)3.77982832
60kidney mesenchyme development (GO:0072074)3.76626704
61multicellular organismal development (GO:0007275)3.74097277
62meiosis I (GO:0007127)3.73702187
63histamine transport (GO:0051608)3.71601652
64amyloid precursor protein catabolic process (GO:0042987)3.71222873
65neural crest cell development (GO:0014032)3.70653733
66uterus development (GO:0060065)3.70122499
67synaptic transmission, dopaminergic (GO:0001963)3.66085471
68genitalia morphogenesis (GO:0035112)3.64393317
69protein retention in ER lumen (GO:0006621)3.60170873
70protein polyglutamylation (GO:0018095)3.49755135
71single strand break repair (GO:0000012)3.49172017
72spinal cord development (GO:0021510)3.49100758
73regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.47363074
74axoneme assembly (GO:0035082)3.47006087
75negative regulation of axon extension involved in axon guidance (GO:0048843)3.43833226
76protein maturation by protein folding (GO:0022417)3.42474743
77muscle cell proliferation (GO:0033002)3.40578976
78neuron projection extension involved in neuron projection guidance (GO:1902284)3.38813312
79axon extension involved in axon guidance (GO:0048846)3.38813312
80aggressive behavior (GO:0002118)3.33618546
81platelet dense granule organization (GO:0060155)3.31887719
82pattern specification involved in kidney development (GO:0061004)3.31754117
83spinal cord association neuron differentiation (GO:0021527)3.30107819
84glycolytic process (GO:0006096)3.29643189
85alditol metabolic process (GO:0019400)3.28252767
86serine transport (GO:0032329)3.27546524
87negative regulation of homotypic cell-cell adhesion (GO:0034111)3.26386503
88lipopolysaccharide biosynthetic process (GO:0009103)3.26287689
89negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.26057534
90protein localization to cilium (GO:0061512)3.23780771
91meiotic cell cycle (GO:0051321)3.23095811
92cranial nerve morphogenesis (GO:0021602)3.22970332
93cochlea morphogenesis (GO:0090103)3.21249515
94negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.21103392
95negative regulation of chondrocyte differentiation (GO:0032331)3.19082501
96glomerular filtration (GO:0003094)3.18590695
97potassium ion import (GO:0010107)3.16864304
98negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.16794878
99GTP biosynthetic process (GO:0006183)3.16632013
100negative regulation of cartilage development (GO:0061037)3.15251426
101outflow tract septum morphogenesis (GO:0003148)3.13147007
102atrioventricular valve morphogenesis (GO:0003181)3.13046049
103protein refolding (GO:0042026)3.12799733
104peptidyl-arginine omega-N-methylation (GO:0035247)3.11299220
105behavioral response to ethanol (GO:0048149)3.11234628
106vascular smooth muscle contraction (GO:0014829)3.10410744
107L-serine transport (GO:0015825)3.09468963
108erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.08250726
109L-phenylalanine metabolic process (GO:0006558)3.08250726
110regulation of response to osmotic stress (GO:0047484)3.06020537
111chondrocyte development (GO:0002063)3.04169354
112microtubule-based movement (GO:0007018)3.03457305
113negative regulation of chemokine production (GO:0032682)3.02095683
114microtubule polymerization or depolymerization (GO:0031109)3.00767723
115establishment of endothelial barrier (GO:0061028)2.99701762
116cilium organization (GO:0044782)2.99263764
117mesenchymal cell development (GO:0014031)2.98298116
118positive regulation of macrophage activation (GO:0043032)2.97734644
119embryonic skeletal joint morphogenesis (GO:0060272)2.97370024
120renal filtration (GO:0097205)2.97016441
121RNA localization (GO:0006403)2.95396669
122regulation of spindle checkpoint (GO:0090231)2.95225657
123inositol metabolic process (GO:0006020)2.94197504
124azole transport (GO:0045117)2.92993574
125cellular extravasation (GO:0045123)2.91422261
126sequestering of actin monomers (GO:0042989)2.90383152
127monoubiquitinated protein deubiquitination (GO:0035520)2.89800433
128L-phenylalanine catabolic process (GO:0006559)2.88884632
129erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.88884632
130negative regulation of cell aging (GO:0090344)2.87886292
131endocardial cushion morphogenesis (GO:0003203)2.85924919
132intraciliary transport (GO:0042073)2.85759444
133polyol catabolic process (GO:0046174)2.85524193
134organ formation (GO:0048645)2.85067702
135apical protein localization (GO:0045176)2.84663880
136negative regulation of defense response to virus (GO:0050687)2.84126697
137UTP biosynthetic process (GO:0006228)2.84098954
138glycerol metabolic process (GO:0006071)2.83765913
139cellular component assembly involved in morphogenesis (GO:0010927)2.83469800
140cilium morphogenesis (GO:0060271)2.83396958
141protein K11-linked deubiquitination (GO:0035871)2.83159317
142chaperone-mediated protein transport (GO:0072321)2.82177822
143neuron fate specification (GO:0048665)2.81873940
144cilium assembly (GO:0042384)2.81776322
145protein heterotrimerization (GO:0070208)2.81448730
146cardiac epithelial to mesenchymal transition (GO:0060317)2.81271971
147histone arginine methylation (GO:0034969)2.80428490
148nucleus organization (GO:0006997)2.79794456
149embryonic forelimb morphogenesis (GO:0035115)2.77958267
150response to parathyroid hormone (GO:0071107)2.77063994
151pre-miRNA processing (GO:0031054)2.76778093
152negative regulation of axon guidance (GO:1902668)2.76708630
153proximal/distal pattern formation (GO:0009954)2.76612094
154negative regulation of response to biotic stimulus (GO:0002832)2.75611210
155embryonic viscerocranium morphogenesis (GO:0048703)2.73753027
156cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.73576864
157vascular endothelial growth factor signaling pathway (GO:0038084)2.73148881
158quaternary ammonium group transport (GO:0015697)2.72190130
159nucleoside diphosphate catabolic process (GO:0009134)2.72157875
160regulation of odontogenesis (GO:0042481)2.71680236
161rRNA methylation (GO:0031167)2.70433644
162lipopolysaccharide metabolic process (GO:0008653)2.69593569
163negative regulation of organelle assembly (GO:1902116)2.69423707
164negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.68970817
165cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.68792726
166regulation of metalloenzyme activity (GO:0048552)2.68499219
167UTP metabolic process (GO:0046051)2.67727474
168positive regulation of cartilage development (GO:0061036)2.67718992
169midgut development (GO:0007494)2.67434347
170galactose catabolic process (GO:0019388)2.66996296
171post-embryonic morphogenesis (GO:0009886)2.66854759
172peptidyl-arginine N-methylation (GO:0035246)2.64048604
173peptidyl-arginine methylation (GO:0018216)2.64048604
174negative regulation of JUN kinase activity (GO:0043508)2.61519381
175virion assembly (GO:0019068)2.60739490
176cellular response to estradiol stimulus (GO:0071392)2.60284434
177peptidyl-glutamic acid modification (GO:0018200)2.58836833
178GDP-mannose metabolic process (GO:0019673)2.56671844
179mitotic sister chromatid cohesion (GO:0007064)2.55683483
180vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.55488637
181RNA destabilization (GO:0050779)2.55450859
182wound healing, spreading of epidermal cells (GO:0035313)2.54614693
183regulation of cilium assembly (GO:1902017)2.54149022
184positive regulation of glycolytic process (GO:0045821)2.52529029
185cellular hyperosmotic response (GO:0071474)2.52090253
186interferon-gamma secretion (GO:0072643)2.50882228
187gene silencing by RNA (GO:0031047)2.46284123
188sperm motility (GO:0030317)13.7036626
189fusion of sperm to egg plasma membrane (GO:0007342)12.7214670
190acrosome reaction (GO:0007340)11.9236734
191cell wall macromolecule catabolic process (GO:0016998)11.8122311
192cell wall macromolecule metabolic process (GO:0044036)11.8122311
193sperm-egg recognition (GO:0035036)11.0792857
194acrosome assembly (GO:0001675)10.7566454
195cilium or flagellum-dependent cell motility (GO:0001539)10.5422976
196epithelial cilium movement (GO:0003351)10.4711794
197multicellular organism reproduction (GO:0032504)10.3722585
198binding of sperm to zona pellucida (GO:0007339)10.0879235
199axonemal dynein complex assembly (GO:0070286)10.0684336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.08971568
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.81079622
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.08434034
4EZH2_22144423_ChIP-Seq_EOC_Human3.91044366
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.58079606
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.10433287
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.96749684
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.95366877
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.77126449
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46867532
11ZNF263_19887448_ChIP-Seq_K562_Human2.39711578
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.38680781
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.37093933
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.36095204
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.35122018
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31928782
17LXR_22292898_ChIP-Seq_THP-1_Human2.31657895
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.21667045
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.20039718
20VDR_22108803_ChIP-Seq_LS180_Human2.17424673
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.13654998
22ELK4_26923725_Chip-Seq_MESODERM_Mouse2.09365829
23CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.07928940
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06581768
25RACK7_27058665_Chip-Seq_MCF-7_Human2.01999552
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.00966927
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.99706156
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.98085958
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.94918935
30TP53_20018659_ChIP-ChIP_R1E_Mouse1.93069087
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.91059239
32CLOCK_20551151_ChIP-Seq_293T_Human1.91052468
33ZNF274_21170338_ChIP-Seq_K562_Hela1.88168045
34* EZH2_27304074_Chip-Seq_ESCs_Mouse1.87533149
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85880205
36VDR_21846776_ChIP-Seq_THP-1_Human1.85519815
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.82495963
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.81497758
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.76525832
40* SA1_27219007_Chip-Seq_ERYTHROID_Human1.76017351
41FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75058192
42STAT1_17558387_ChIP-Seq_HELA_Human1.72021129
43KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70333469
44TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.70100336
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.68701863
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67764951
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66593198
48SOX2_22085726_ChIP-Seq_NPCs_Mouse1.61842270
49MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59926496
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.56487850
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55889127
52CBP_20019798_ChIP-Seq_JUKART_Human1.55889127
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55378796
54* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.55046265
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53122797
56GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.51588643
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48684883
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47403451
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46756722
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46367874
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43430859
62P53_21459846_ChIP-Seq_SAOS-2_Human1.42906642
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42841856
64GATA3_21867929_ChIP-Seq_CD8_Mouse1.41996757
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39783368
66RAD21_21589869_ChIP-Seq_MESCs_Mouse1.38993858
67FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38740224
68* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.38277933
69TAL1_26923725_Chip-Seq_HPCs_Mouse1.35685872
70KDM2B_26808549_Chip-Seq_REH_Human1.35176259
71SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.33460636
72LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.32727406
73RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32398790
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32398790
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32274636
76KDM2B_26808549_Chip-Seq_K562_Human1.31525504
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31343091
78* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30789944
79UBF1/2_26484160_Chip-Seq_HMECs_Human1.30656200
80P68_20966046_ChIP-Seq_HELA_Human1.30547593
81GF1_26923725_Chip-Seq_HPCs_Mouse1.29953612
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29691001
83CREB1_26743006_Chip-Seq_LNCaP_Human1.28660273
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27747566
85XRN2_22483619_ChIP-Seq_HELA_Human1.27703939
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26825184
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26817111
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26817111
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26516278
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26325262
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25140148
92CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24786098
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.24384273
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.23288473
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22694377
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22467860
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.22343707
98CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22211153
99* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.22051104
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22013472
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21804588
102* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21735472
103JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21155863
104ERG_20517297_ChIP-Seq_VCAP_Human1.20981026
105* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20187723
106* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19858687
107ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.19314552
108MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18969119
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17321276
110MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17006711
111EZH2_27294783_Chip-Seq_ESCs_Mouse1.16514493
112KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16110833
113TP63_19390658_ChIP-ChIP_HaCaT_Human1.16091704
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16064762
115GATA3_21867929_ChIP-Seq_TH1_Mouse1.15934850
116SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15757619
117* CTCF_21964334_Chip-Seq_Bcells_Human1.15684969
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15374844
119SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13561692
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12023563
121ATF3_27146783_Chip-Seq_COLON_Human1.11424248
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11368501
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11316509
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11255005
125STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.11161527
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.10754787
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09470566
128TP53_22127205_ChIP-Seq_IMR90_Human1.09447133
129RXR_22158963_ChIP-Seq_LIVER_Mouse1.08984052
130BCL6_27268052_Chip-Seq_Bcells_Human1.08701126
131YY1_22570637_ChIP-Seq_MALME-3M_Human1.08691675
132* SMC4_20622854_ChIP-Seq_HELA_Human1.08276547
133CTCF_27219007_Chip-Seq_Bcells_Human1.08181711
134FOXP1_21924763_ChIP-Seq_HESCs_Human1.07392975
135* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07340659
136THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07339882
137KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07307079
138ELF1_20517297_ChIP-Seq_JURKAT_Human1.07252030
139SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07228887
140MYC_27129775_Chip-Seq_CORNEA_Mouse1.07010113
141TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06759059
142GATA1_19941827_ChIP-Seq_MEL86_Mouse1.06720527
143RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06576929
144TET1_21490601_ChIP-Seq_MESCs_Mouse1.06394967
145MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06257173
146SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06047434
147TP63_17297297_ChIP-ChIP_HaCaT_Human1.05986894
148SPI1_26923725_Chip-Seq_HPCs_Mouse1.05746608
149KDM2B_26808549_Chip-Seq_DND41_Human1.05661825
150CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05394303
151NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05298719
152* REST_21632747_ChIP-Seq_MESCs_Mouse1.05189717
153RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05102495
154RARA_24833708_ChIP-Seq_LIVER_Mouse1.03906465
155SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03890716
156RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03318514
157CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03146138
158SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.02845861
159ESR2_21235772_ChIP-Seq_MCF-7_Human1.02665609
160RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02619044
161CRX_20693478_ChIP-Seq_RETINA_Mouse1.02267426
162SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01633581
163GABP_17652178_ChIP-ChIP_JURKAT_Human1.01477178
164ESET_19884257_ChIP-Seq_ESCs_Mouse1.00340926
165ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99405359
166PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98889742
167LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97938052
168SA1_22415368_ChIP-Seq_MEFs_Mouse0.97801619
169SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97780121
170TET1_21451524_ChIP-Seq_MESCs_Mouse0.97480426
171RING1B_27294783_Chip-Seq_NPCs_Mouse0.97090392
172VDR_24763502_ChIP-Seq_THP-1_Human0.97061417
173NANOG_20526341_ChIP-Seq_ESCs_Human0.96871052
174* SA1_27219007_Chip-Seq_Bcells_Human0.96861287
175CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96842026
176NFYB_21822215_ChIP-Seq_K562_Human0.96755578
177CTCF_20526341_ChIP-Seq_ESCs_Human0.96405721
178SMAD4_21741376_ChIP-Seq_EPCs_Human0.96032159
179JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94179648
180GF1B_26923725_Chip-Seq_HPCs_Mouse0.92969242
181SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92668474
182CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92176676
183* FLI1_21867929_ChIP-Seq_CD8_Mouse0.92014683
184* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92002114
185SOX11_22085726_ChIP-Seq_ESNs_Mouse0.90641202
186MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90483775
187TBL1_22424771_ChIP-Seq_293T_Human0.89743835
188NANOG_18555785_Chip-Seq_ESCs_Mouse0.89139716
189SOX2_21211035_ChIP-Seq_LN229_Human0.88914282
190CSB_26484114_Chip-Seq_FIBROBLAST_Human0.88872136
191* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88282149
192BCOR_27268052_Chip-Seq_Bcells_Human0.87312823
193TAF15_26573619_Chip-Seq_HEK293_Human0.84871435

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.56489606
2MP0006054_spinal_hemorrhage5.48798434
3MP0001929_abnormal_gametogenesis5.00559616
4MP0005670_abnormal_white_adipose4.17430679
5MP0003646_muscle_fatigue3.74515616
6MP0002009_preneoplasia3.62678351
7MP0003315_abnormal_perineum_morphology3.33720419
8MP0000049_abnormal_middle_ear3.31030599
9MP0008877_abnormal_DNA_methylation3.15565078
10MP0002210_abnormal_sex_determination3.03586054
11MP0002161_abnormal_fertility/fecundity3.01072595
12MP0001879_abnormal_lymphatic_vessel2.74520798
13MP0010030_abnormal_orbit_morphology2.69662060
14MP0003279_aneurysm2.67024225
15MP0000516_abnormal_urinary_system2.54495107
16MP0005367_renal/urinary_system_phenotyp2.54495107
17MP0001145_abnormal_male_reproductive2.49540950
18MP0000678_abnormal_parathyroid_gland2.35796375
19MP0004272_abnormal_basement_membrane2.29892122
20MP0002653_abnormal_ependyma_morphology2.25682166
21MP0000653_abnormal_sex_gland2.14053190
22MP0009053_abnormal_anal_canal2.12756908
23MP0005508_abnormal_skeleton_morphology2.12368125
24MP0005410_abnormal_fertilization15.5346841
25MP0005623_abnormal_meninges_morphology1.90899428
26MP0002166_altered_tumor_susceptibility1.86354938
27MP0002282_abnormal_trachea_morphology1.78677726
28MP0009384_cardiac_valve_regurgitation1.76515993
29MP0000537_abnormal_urethra_morphology1.73231657
30MP0002254_reproductive_system_inflammat1.60724735
31MP0000613_abnormal_salivary_gland1.57929327
32MP0005666_abnormal_adipose_tissue1.56114958
33MP0004233_abnormal_muscle_weight1.50572615
34MP0005187_abnormal_penis_morphology1.48944624
35MP0002160_abnormal_reproductive_system1.48840773
36MP0003938_abnormal_ear_development1.48790198
37MP0000767_abnormal_smooth_muscle1.42219970
38MP0002006_tumorigenesis1.42062718
39MP0005058_abnormal_lysosome_morphology1.36644747
40MP0002938_white_spotting1.30540311
41MP0000762_abnormal_tongue_morphology1.29452970
42MP0000003_abnormal_adipose_tissue1.28276374
43MP0004134_abnormal_chest_morphology1.22731157
44MP0002249_abnormal_larynx_morphology1.22421688
45MP0000751_myopathy1.22400993
46MP0005076_abnormal_cell_differentiation1.21185610
47MP0003122_maternal_imprinting1.20749107
48MP0005330_cardiomyopathy1.16122753
49MP0005503_abnormal_tendon_morphology1.13010247
50MP0008775_abnormal_heart_ventricle1.12182671
51MP0003755_abnormal_palate_morphology1.07067116
52MP0001765_abnormal_ion_homeostasis1.06376754
53MP0005332_abnormal_amino_acid1.03808649
54MP0003123_paternal_imprinting1.03284054
55MP0003935_abnormal_craniofacial_develop1.03167172
56MP0002116_abnormal_craniofacial_bone1.02331054
57MP0000343_altered_response_to0.99786379
58MP0000750_abnormal_muscle_regeneration0.98257257
59MP0002909_abnormal_adrenal_gland0.95818087
60MP0002971_abnormal_brown_adipose0.95726871
61MP0001915_intracranial_hemorrhage0.95651956
62MP0008875_abnormal_xenobiotic_pharmacok0.95635664
63MP0000681_abnormal_thyroid_gland0.95556101
64MP0001485_abnormal_pinna_reflex0.95343083
65MP0003385_abnormal_body_wall0.93732478
66MP0005390_skeleton_phenotype0.93583488
67MP0000538_abnormal_urinary_bladder0.91011041
68MP0003448_altered_tumor_morphology0.90476643
69MP0008004_abnormal_stomach_pH0.88935086
70MP0002114_abnormal_axial_skeleton0.88299118
71MP0002932_abnormal_joint_morphology0.87313674
72MP0003172_abnormal_lysosome_physiology0.86839814
73MP0002060_abnormal_skin_morphology0.86652082
74MP0003878_abnormal_ear_physiology0.83716794
75MP0005377_hearing/vestibular/ear_phenot0.83716794
76MP0003950_abnormal_plasma_membrane0.83456188
77MP0009250_abnormal_appendicular_skeleto0.83232370
78MP0005375_adipose_tissue_phenotype0.82967753
79MP0003879_abnormal_hair_cell0.82503600
80MP0000639_abnormal_adrenal_gland0.82248458
81MP0002132_abnormal_respiratory_system0.81063811
82MP0003705_abnormal_hypodermis_morpholog0.80798341
83MP0005083_abnormal_biliary_tract0.80528124
84MP0000569_abnormal_digit_pigmentation0.80516092
85MP0003828_pulmonary_edema0.80136515
86MP0004036_abnormal_muscle_relaxation0.79139532
87MP0009115_abnormal_fat_cell0.78758867
88MP0004130_abnormal_muscle_cell0.74766684
89MP0003075_altered_response_to0.72326051
90MP0008438_abnormal_cutaneous_collagen0.70711567
91MP0000428_abnormal_craniofacial_morphol0.70127333
92MP0003566_abnormal_cell_adhesion0.69890848
93MP0002877_abnormal_melanocyte_morpholog0.69367079
94MP0002177_abnormal_outer_ear0.69003745
95MP0001324_abnormal_eye_pigmentation0.67977214
96MP0002115_abnormal_skeleton_extremities0.67650236
97MP0002933_joint_inflammation0.67584667
98MP0001542_abnormal_bone_strength0.65649237
99MP0003329_amyloid_beta_deposits0.65202927
100MP0001340_abnormal_eyelid_morphology0.65193638
101MP0000026_abnormal_inner_ear0.65084812
102MP0003283_abnormal_digestive_organ0.64598590
103MP0002111_abnormal_tail_morphology0.64276057
104MP0002822_catalepsy0.63967215
105MP0001986_abnormal_taste_sensitivity0.63633041
106MP0009046_muscle_twitch0.62906595
107MP0005164_abnormal_response_to0.62157537
108MP0000372_irregular_coat_pigmentation0.61304669
109MP0005389_reproductive_system_phenotype0.61201652
110MP0001984_abnormal_olfaction0.60749949
111MP0001756_abnormal_urination0.60533428
112MP0005636_abnormal_mineral_homeostasis0.60262843
113MP0001614_abnormal_blood_vessel0.58724914
114MP0003115_abnormal_respiratory_system0.58305796
115MP0008961_abnormal_basal_metabolism0.57432159
116MP0002128_abnormal_blood_circulation0.57165214
117MP0000249_abnormal_blood_vessel0.55988305
118MP0003091_abnormal_cell_migration0.55417727
119MP0002108_abnormal_muscle_morphology0.54766063
120MP0001270_distended_abdomen0.54736998
121MP0005647_abnormal_sex_gland0.53415438
122MP0002109_abnormal_limb_morphology0.53055500
123MP0002269_muscular_atrophy0.50288735
124MP0001661_extended_life_span0.49836213
125MP0000358_abnormal_cell_content/0.49415123
126MP0002234_abnormal_pharynx_morphology0.47957188
127MP0002896_abnormal_bone_mineralization0.47762053
128MP0001849_ear_inflammation0.47143427
129MP0000163_abnormal_cartilage_morphology0.46942016
130MP0003011_delayed_dark_adaptation0.46890242
131MP0010329_abnormal_lipoprotein_level0.45234604
132MP0005275_abnormal_skin_tensile0.43988273
133MP0002970_abnormal_white_adipose0.43323304
134MP0005397_hematopoietic_system_phenotyp0.42804488
135MP0001545_abnormal_hematopoietic_system0.42804488
136MP0000604_amyloidosis0.42531846
137MP0001764_abnormal_homeostasis0.42031085
138MP0003948_abnormal_gas_homeostasis0.41604183
139MP0004084_abnormal_cardiac_muscle0.40707673
140MP0001293_anophthalmia0.39844522
141MP0002118_abnormal_lipid_homeostasis0.39276071
142MP0005423_abnormal_somatic_nervous0.39158611
143MP0003959_abnormal_lean_body0.38370646
144MP0009780_abnormal_chondrocyte_physiolo0.37921186
145MP0004087_abnormal_muscle_fiber0.37331857
146MP0001299_abnormal_eye_distance/0.37182207
147MP0003699_abnormal_female_reproductive0.36220059
148MP0006036_abnormal_mitochondrial_physio0.36014426
149MP0002295_abnormal_pulmonary_circulatio0.35142479
150MP0005334_abnormal_fat_pad0.35078278
151MP0001533_abnormal_skeleton_physiology0.34259833
152MP0003942_abnormal_urinary_system0.32508788
153MP0005171_absent_coat_pigmentation0.32504609
154MP0003045_fibrosis0.32492237
155MP0002089_abnormal_postnatal_growth/wei0.29932831
156MP0000013_abnormal_adipose_tissue0.29524299
157MP0000534_abnormal_ureter_morphology0.29317108
158MP0004133_heterotaxia0.29165097
159MP0000749_muscle_degeneration0.28391201
160MP0004185_abnormal_adipocyte_glucose0.28317921
161MP0005535_abnormal_body_temperature0.28023888
162MP0002113_abnormal_skeleton_development0.27717088
163MP0002998_abnormal_bone_remodeling0.26970458
164MP0005253_abnormal_eye_physiology0.26466255
165MP0002106_abnormal_muscle_physiology0.25909342
166MP0000462_abnormal_digestive_system0.25445993
167MP0001727_abnormal_embryo_implantation0.25075310
168MP0008995_early_reproductive_senescence0.24911649
169MP0000432_abnormal_head_morphology0.24282368
170MP0009278_abnormal_bone_marrow0.24126974
171MP0005257_abnormal_intraocular_pressure0.23623683
172MP0000759_abnormal_skeletal_muscle0.23314397
173MP0005408_hypopigmentation0.22983622

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.11273756
2Abnormal respiratory epithelium morphology (HP:0012253)8.44174563
3Abnormal respiratory motile cilium morphology (HP:0005938)8.44174563
4Rhinitis (HP:0012384)7.69340673
5Abnormal ciliary motility (HP:0012262)7.40604368
6Chronic bronchitis (HP:0004469)6.47031865
7Infertility (HP:0000789)6.30733620
8Nasal polyposis (HP:0100582)5.82293741
9Severe visual impairment (HP:0001141)4.94290553
10Septo-optic dysplasia (HP:0100842)4.78003929
11Abnormality of the nasal mucosa (HP:0000433)4.77570556
12Hyperthyroidism (HP:0000836)4.62026195
13Nausea (HP:0002018)4.29390202
14Bronchiectasis (HP:0002110)4.25317642
15Bronchitis (HP:0012387)4.19265806
16Male infertility (HP:0003251)4.19000927
17Premature rupture of membranes (HP:0001788)3.99998429
18Large for gestational age (HP:0001520)3.81872146
19Nephronophthisis (HP:0000090)3.66849926
20Amblyopia (HP:0000646)3.63275045
21Coronal craniosynostosis (HP:0004440)3.40475560
22Recurrent otitis media (HP:0000403)3.21248444
23Small epiphyses (HP:0010585)3.03874284
24Irregular epiphyses (HP:0010582)2.97445862
25Abnormal spermatogenesis (HP:0008669)2.92454175
26Recurrent sinusitis (HP:0011108)2.90238421
27Epiphyseal dysplasia (HP:0002656)2.88075000
28Hypoplastic left heart (HP:0004383)2.87595184
29Glossoptosis (HP:0000162)2.82657825
30Ulnar bowing (HP:0003031)2.79227898
31Ankyloglossia (HP:0010296)2.74820437
32Abnormality of the renal medulla (HP:0100957)2.72195434
33Delayed epiphyseal ossification (HP:0002663)2.69526333
34Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.68634500
35Recurrent bronchitis (HP:0002837)2.67421766
36Abnormality of the aortic arch (HP:0012303)2.64790490
37Short femoral neck (HP:0100864)2.63971616
38Increased number of teeth (HP:0011069)2.63552961
39Hypokinesia (HP:0002375)2.60759057
40Axonal loss (HP:0003447)2.57149661
41Tubulointerstitial nephritis (HP:0001970)2.56095630
42Short hallux (HP:0010109)2.55430293
43Absent septum pellucidum (HP:0001331)2.53556245
44Hypoplastic heart (HP:0001961)2.51181872
45Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.50981981
46Absent epiphyses (HP:0010577)2.50981981
47Soft skin (HP:0000977)2.50620252
48Testicular neoplasm (HP:0010788)2.49388854
49Nuclear cataract (HP:0100018)2.48990661
50Submucous cleft hard palate (HP:0000176)2.46513885
51Increased serum pyruvate (HP:0003542)2.44357240
52Abnormal vertebral ossification (HP:0100569)2.41237425
53Type I transferrin isoform profile (HP:0003642)2.38216574
54Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.38059940
55Tubular atrophy (HP:0000092)2.37739157
56Septate vagina (HP:0001153)2.37019185
57Myocardial infarction (HP:0001658)2.35895394
58Short ribs (HP:0000773)2.33976156
59Abnormality of glycolysis (HP:0004366)2.30487276
60Growth hormone excess (HP:0000845)2.29269324
61Tubulointerstitial abnormality (HP:0001969)2.28895484
62Seborrheic dermatitis (HP:0001051)2.28893756
63Diminished movement (HP:0002374)2.27958829
64Abnormal gallbladder physiology (HP:0012438)2.26871136
65Cholecystitis (HP:0001082)2.26871136
66Disproportionate short-trunk short stature (HP:0003521)2.24219118
67Impulsivity (HP:0100710)2.22304477
68Cerebral aneurysm (HP:0004944)2.22123773
69Akinesia (HP:0002304)2.21362701
70Elbow flexion contracture (HP:0002987)2.20845294
71Short nail (HP:0001799)2.19251052
72Abnormality of carpal bone ossification (HP:0006257)2.19152860
73Hyperparathyroidism (HP:0000843)2.17455663
74Ureteral duplication (HP:0000073)2.16097161
75Atelectasis (HP:0100750)2.15749004
76Bell-shaped thorax (HP:0001591)2.12897779
77Renal Fanconi syndrome (HP:0001994)2.11946716
78Abnormality of oral frenula (HP:0000190)2.11892101
79Hypoalphalipoproteinemia (HP:0003233)2.11837917
80Truncus arteriosus (HP:0001660)2.11333029
81Aplasia/Hypoplasia of the hallux (HP:0008362)2.10136417
82Congenital malformation of the right heart (HP:0011723)2.09578029
83Double outlet right ventricle (HP:0001719)2.09578029
84Ulnar claw (HP:0001178)2.08685545
85Molar tooth sign on MRI (HP:0002419)2.07287477
86Abnormality of midbrain morphology (HP:0002418)2.07287477
87Gonadotropin excess (HP:0000837)2.07079075
88Flattened epiphyses (HP:0003071)2.06642779
89Abnormal number of incisors (HP:0011064)2.06285506
90Irregular vertebral endplates (HP:0003301)2.05922684
91Increased muscle lipid content (HP:0009058)2.03318937
92Fibular hypoplasia (HP:0003038)2.01996005
93Abnormality of the epiphysis of the femoral head (HP:0010574)2.00380589
94Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.00091539
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.2336750
96Dynein arm defect of respiratory motile cilia (HP:0012255)11.8672327
97Absent/shortened dynein arms (HP:0200106)11.8672327
98Patchy hypopigmentation of hair (HP:0011365)1.98748445
99Exotropia (HP:0000577)1.98623455
100Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98554404
101Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98554404
102Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98395357
103Abnormal tarsal ossification (HP:0008369)1.98054832
104Duplicated collecting system (HP:0000081)1.97919761
105Abnormality of femoral epiphyses (HP:0006499)1.97635575
106Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.97635575
107Tubulointerstitial fibrosis (HP:0005576)1.94552505
108Medial flaring of the eyebrow (HP:0010747)1.94427761
109Prolonged neonatal jaundice (HP:0006579)1.93945503
110Metaphyseal cupping (HP:0003021)1.93165051
111Abnormality of macular pigmentation (HP:0008002)1.92183969
112High anterior hairline (HP:0009890)1.91681959
113Posterior subcapsular cataract (HP:0007787)1.91412457
114Knee flexion contracture (HP:0006380)1.89904091
115Abnormality of the septum pellucidum (HP:0007375)1.88174255
116Patellar dislocation (HP:0002999)1.88043090
117Prominent supraorbital ridges (HP:0000336)1.87725310
118Long palpebral fissure (HP:0000637)1.86309931
119Cupped ribs (HP:0000887)1.85201762
120Flat acetabular roof (HP:0003180)1.85088853
121Subcapsular cataract (HP:0000523)1.83062066
122Thoracolumbar scoliosis (HP:0002944)1.82557750
123Abnormality of the femoral head (HP:0003368)1.81331628
124Abnormality of monocarboxylic acid metabolism (HP:0010996)1.80499736
125Arterial tortuosity (HP:0005116)1.79799766
126Spinal rigidity (HP:0003306)1.77941876
127Short thorax (HP:0010306)1.77478913
128Postaxial foot polydactyly (HP:0001830)1.77364079
129Vacuolated lymphocytes (HP:0001922)1.76533535
130Metaphyseal dysplasia (HP:0100255)1.76200594
131Venous insufficiency (HP:0005293)1.75996220
132Aplasia/hypoplasia of the femur (HP:0005613)1.75769511
133Vascular tortuosity (HP:0004948)1.75054583
134Bradycardia (HP:0001662)1.74980603
135Ulnar deviation of the wrist (HP:0003049)1.73728209
136Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72747884
137Abnormal protein N-linked glycosylation (HP:0012347)1.72747884
138Abnormal protein glycosylation (HP:0012346)1.72747884
139Abnormal glycosylation (HP:0012345)1.72747884
140Azoospermia (HP:0000027)1.72615399
141Spastic tetraparesis (HP:0001285)1.72536095
142Venous abnormality (HP:0002624)1.72000367
143Amyloidosis (HP:0011034)1.69765190
144Abnormality of dentin (HP:0010299)1.69680950
145White forelock (HP:0002211)1.69615794
146Dyschromatopsia (HP:0007641)1.69359210
147Microglossia (HP:0000171)1.68203536
148Hand muscle atrophy (HP:0009130)1.68188164
149Pulmonary artery stenosis (HP:0004415)1.68021431
150Genu recurvatum (HP:0002816)1.67418794
151Myoglobinuria (HP:0002913)1.67336387
152Abnormality of the tricuspid valve (HP:0001702)1.67133574
153Insulin-resistant diabetes mellitus (HP:0000831)1.67109856
154Hemorrhage of the eye (HP:0011885)1.66176575
155Hypoplastic ischia (HP:0003175)1.65663969
156Abnormality of the vertebral endplates (HP:0005106)1.65102408
157Abnormality of the columella (HP:0009929)1.63880785
158Protrusio acetabuli (HP:0003179)1.63684553
159Absent frontal sinuses (HP:0002688)1.62199833
160Flat capital femoral epiphysis (HP:0003370)1.61562853
161Asymmetric septal hypertrophy (HP:0001670)1.60585201
162Increased intramyocellular lipid droplets (HP:0012240)1.60374645
163Acanthosis nigricans (HP:0000956)1.59006039
164Genu varum (HP:0002970)1.58769602
165Adrenal hypoplasia (HP:0000835)1.58663203
166Stage 5 chronic kidney disease (HP:0003774)1.57989220
167Menstrual irregularities (HP:0000858)1.57683395
168Difficulty running (HP:0009046)1.56633170
169Abnormality of renal resorption (HP:0011038)1.56582916
170Blue sclerae (HP:0000592)1.55714460
171Hypercortisolism (HP:0001578)1.55227327
172Neurofibrillary tangles (HP:0002185)1.55011669
173Rhizomelia (HP:0008905)1.53639649
174Heterotopia (HP:0002282)1.53216999
175Abnormal biliary tract physiology (HP:0012439)1.53003312
176Bile duct proliferation (HP:0001408)1.53003312
177Choroideremia (HP:0001139)1.50668454
178Decreased central vision (HP:0007663)1.50298563
179Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.49920619
180Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.47796711
181Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.47655770
182Abnormality of the renal cortex (HP:0011035)1.47409526
183Congenital hepatic fibrosis (HP:0002612)1.47149449
184Exercise-induced myalgia (HP:0003738)1.46876344
185Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.45714924
186Abnormality of the dental root (HP:0006486)1.44321747
187Taurodontia (HP:0000679)1.44321747
188Abnormality of permanent molar morphology (HP:0011071)1.44321747
189Vitreoretinal degeneration (HP:0000655)1.43567697
190Rhabdomyolysis (HP:0003201)1.43403152
191Protuberant abdomen (HP:0001538)1.42347854
192Beaking of vertebral bodies (HP:0004568)1.42256027
193Abnormality of the ischium (HP:0003174)1.41065166
194Limited elbow extension (HP:0001377)1.39472105
195Mild short stature (HP:0003502)1.39414033
196Abnormal drinking behavior (HP:0030082)1.38980730

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.98964225
2PDK47.98964225
3TESK16.30654979
4PDK25.24606429
5PRKD35.09354100
6STK164.54221855
7ICK4.46739965
8LRRK23.59110372
9EPHA22.67520579
10ARAF2.45412124
11PTK2B2.33520035
12EIF2AK32.17528922
13PNCK2.08431861
14WNK42.01522141
15NME21.95073699
16ABL21.94299737
17RIPK11.90610372
18STK391.90112032
19IRAK31.88282230
20MAP3K81.85806300
21DMPK1.80962650
22ADRBK11.80447803
23BRSK21.80286647
24MAPK151.75931135
25STK381.61771874
26DYRK1B1.59133667
27BRSK11.56411879
28RAF11.49208128
29MAP3K21.46132359
30YES11.42696030
31NEK21.37820953
32ROCK11.37159501
33PDGFRA1.28568681
34ROCK21.26090694
35PDK11.23765509
36ERN11.16703272
37CAMK1G1.16291363
38TAOK21.10691752
39LIMK11.07850123
40NME11.04607965
41ILK1.01435205
42TRIM280.99979562
43TRIB30.99904160
44MAPK70.94807835
45DDR20.93625894
46RPS6KA20.89680032
47IRAK10.88722778
48MYLK0.87554016
49MOS0.83457113
50LATS20.83071438
51PDPK10.82636515
52GRK50.81871193
53PTK20.79149405
54TYRO30.79140386
55CDK120.77375920
56STK30.76155711
57TGFBR20.75880410
58EPHB20.73933484
59RPS6KC10.69306479
60RPS6KL10.69306479
61MAPK120.68796601
62TLK10.66314148
63DYRK30.66067123
64MAP2K10.65070547
65WNK10.64370730
66KIT0.63706166
67TSSK60.60789064
68MST1R0.59856900
69PASK0.59649545
70EEF2K0.58131146
71TBK10.57421907
72MAPK110.56417648
73STK38L0.56259921
74MAP2K30.56040104
75VRK10.54079289
76KDR0.53970677
77LMTK20.51527269
78RPS6KA60.49748945
79RPS6KB20.49618485
80NTRK20.49292044
81TTK0.49032491
82PAK20.48578718
83CCNB10.46737529
84PRKG20.45932833
85PINK10.43799519
86TNIK0.43202830
87PAK10.42436728
88RIPK40.38653621
89SIK30.38542988
90IRAK40.38271090
91CAMK1D0.37926279
92PRPF4B0.37813528
93MAP2K20.37750755
94CHEK20.36746681
95MTOR0.35955322
96IRAK20.34356350
97AURKA0.34277684
98SMG10.33679706
99CSNK1G30.33575457
100MAP2K60.32250134
101NUAK10.31582638
102ADRBK20.30714299
103TYK20.30232459
104VRK20.30043351
105CAMKK10.29645298
106CDK80.29609387
107PRKD10.29395563
108TESK20.29057792
109CSNK1E0.28851824
110MARK20.28313177
111MUSK0.27997103
112CSNK2A20.27208406
113BRAF0.27154281
114PAK40.27153328
115PBK0.26362814
116EIF2AK20.26074750
117PRKAA10.23695871
118PRKD20.22630427
119PRKCG0.22591009
120SIK10.22554896
121CHEK10.22412629
122MET0.22102568
123MAPKAPK50.20387364
124ATM0.20316444
125PLK40.17183406
126MARK30.16409041
127RPS6KB10.16311869
128PRKCZ0.15929063
129CSK0.14858642
130CDK60.14354610
131GSK3A0.14304546
132NEK60.12681643
133EPHB10.12363853
134PRKCQ0.12131962
135TTN0.11753128
136ATR0.10332205
137PIM20.10120066
138RPS6KA10.09935636
139PRKG10.09399252
140PRKACG0.09284738
141TAOK10.08915118
142BCKDK0.08801482
143PAK60.07126824
144INSR0.05192522
145WEE10.04977240
146MAP3K100.04708917
147STK100.04488217
148BMX0.04140015
149SRC0.04011770
150PRKAA20.03823309
151PIM10.03450758
152PKN10.02706523
153GSK3B0.02581486
154CDK150.01890129
155MAPK80.01733503
156CSNK2A10.01487782
157IGF1R0.01421758
158PDGFRB0.00770974
159LATS10.00633105
160PRKCA0.00129401
161CSF1R0.00016737
162CDK18-0.0164361
163CSNK1D-0.0156211
164CDK4-0.0078672
165PRKCD-0.0077482
166CDK11A-0.0074087
167MAP3K3-0.0069012
168CAMK2A-0.0068718
169PRKDC-0.0012951

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.09373073
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.15442987
3Sulfur relay system_Homo sapiens_hsa041223.99109687
4Propanoate metabolism_Homo sapiens_hsa006403.74898568
5Pyruvate metabolism_Homo sapiens_hsa006203.48258115
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.42830392
7PPAR signaling pathway_Homo sapiens_hsa033202.79061978
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.67842767
9Vitamin B6 metabolism_Homo sapiens_hsa007502.66055537
10Other glycan degradation_Homo sapiens_hsa005112.60216289
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.59499805
12Glucagon signaling pathway_Homo sapiens_hsa049222.54858097
13Linoleic acid metabolism_Homo sapiens_hsa005912.50818847
14Phenylalanine metabolism_Homo sapiens_hsa003602.40401821
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.39475822
16Fatty acid metabolism_Homo sapiens_hsa012122.37387099
17Carbohydrate digestion and absorption_Homo sapiens_hsa049732.20686468
18Glycerolipid metabolism_Homo sapiens_hsa005612.16775575
19Fatty acid degradation_Homo sapiens_hsa000712.12399601
20Galactose metabolism_Homo sapiens_hsa000522.05754411
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.04083384
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.02686231
23Oxidative phosphorylation_Homo sapiens_hsa001901.97451536
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84818817
25Carbon metabolism_Homo sapiens_hsa012001.80446626
26Parkinsons disease_Homo sapiens_hsa050121.77152431
27Vibrio cholerae infection_Homo sapiens_hsa051101.76071185
28Fructose and mannose metabolism_Homo sapiens_hsa000511.74331057
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.71175263
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.60854905
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.59999877
32Pentose phosphate pathway_Homo sapiens_hsa000301.59806699
33Alzheimers disease_Homo sapiens_hsa050101.56139239
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.54723051
35Selenocompound metabolism_Homo sapiens_hsa004501.53942871
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.51498371
37Fat digestion and absorption_Homo sapiens_hsa049751.50767300
38Mineral absorption_Homo sapiens_hsa049781.49722703
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45762939
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42287046
41Huntingtons disease_Homo sapiens_hsa050161.35748475
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34243691
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34170772
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33847812
45Basal transcription factors_Homo sapiens_hsa030221.32803686
46Protein digestion and absorption_Homo sapiens_hsa049741.24459767
47Adipocytokine signaling pathway_Homo sapiens_hsa049201.24055020
48Folate biosynthesis_Homo sapiens_hsa007901.22443461
49Cardiac muscle contraction_Homo sapiens_hsa042601.22203141
50Dorso-ventral axis formation_Homo sapiens_hsa043201.21342980
51Ether lipid metabolism_Homo sapiens_hsa005651.12874716
52Cocaine addiction_Homo sapiens_hsa050301.11416140
53Oocyte meiosis_Homo sapiens_hsa041141.09189701
54Ribosome_Homo sapiens_hsa030101.08786122
55Amphetamine addiction_Homo sapiens_hsa050311.07071701
56Hedgehog signaling pathway_Homo sapiens_hsa043401.06277730
57Complement and coagulation cascades_Homo sapiens_hsa046101.03903803
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02093531
59Glutathione metabolism_Homo sapiens_hsa004800.96661677
60Notch signaling pathway_Homo sapiens_hsa043300.95733429
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92110787
62Renin secretion_Homo sapiens_hsa049240.91282595
63ECM-receptor interaction_Homo sapiens_hsa045120.90728822
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89636756
65Protein export_Homo sapiens_hsa030600.89406905
66RNA polymerase_Homo sapiens_hsa030200.88393956
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88186868
68AMPK signaling pathway_Homo sapiens_hsa041520.87907141
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.84650025
70Biosynthesis of amino acids_Homo sapiens_hsa012300.83469669
71Antigen processing and presentation_Homo sapiens_hsa046120.82577569
72Amoebiasis_Homo sapiens_hsa051460.81207327
73Lysosome_Homo sapiens_hsa041420.81011507
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78586010
75Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77886002
76Focal adhesion_Homo sapiens_hsa045100.77157212
77Purine metabolism_Homo sapiens_hsa002300.76965922
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75891889
79Arachidonic acid metabolism_Homo sapiens_hsa005900.74317086
80Fanconi anemia pathway_Homo sapiens_hsa034600.70690406
81Thyroid hormone synthesis_Homo sapiens_hsa049180.70326475
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.69384996
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66578705
84Legionellosis_Homo sapiens_hsa051340.66006162
85Pyrimidine metabolism_Homo sapiens_hsa002400.65881675
86Vitamin digestion and absorption_Homo sapiens_hsa049770.65197204
87Circadian rhythm_Homo sapiens_hsa047100.64891387
88Sulfur metabolism_Homo sapiens_hsa009200.63171151
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61231945
90Pertussis_Homo sapiens_hsa051330.60916874
91Axon guidance_Homo sapiens_hsa043600.60460474
92Estrogen signaling pathway_Homo sapiens_hsa049150.59144016
93Arginine biosynthesis_Homo sapiens_hsa002200.58024737
94Sphingolipid metabolism_Homo sapiens_hsa006000.55907520
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55756026
96Steroid biosynthesis_Homo sapiens_hsa001000.53892133
97Prion diseases_Homo sapiens_hsa050200.53485890
98Proteasome_Homo sapiens_hsa030500.53432899
99Insulin secretion_Homo sapiens_hsa049110.52439981
100Collecting duct acid secretion_Homo sapiens_hsa049660.52008953
101Proteoglycans in cancer_Homo sapiens_hsa052050.51255034
102Bile secretion_Homo sapiens_hsa049760.50388745
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50300479
104Chemical carcinogenesis_Homo sapiens_hsa052040.48891390
105Small cell lung cancer_Homo sapiens_hsa052220.47369481
106Insulin resistance_Homo sapiens_hsa049310.45973280
107Metabolic pathways_Homo sapiens_hsa011000.44042367
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43434564
109beta-Alanine metabolism_Homo sapiens_hsa004100.41253966
110mRNA surveillance pathway_Homo sapiens_hsa030150.41149865
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40263531
112Melanogenesis_Homo sapiens_hsa049160.39847956
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.39611525
114Calcium signaling pathway_Homo sapiens_hsa040200.39295631
115Starch and sucrose metabolism_Homo sapiens_hsa005000.39135876
116HIF-1 signaling pathway_Homo sapiens_hsa040660.38954618
117Salivary secretion_Homo sapiens_hsa049700.37593264
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36994455
119Pathways in cancer_Homo sapiens_hsa052000.36850418
120Colorectal cancer_Homo sapiens_hsa052100.35181889
121Basal cell carcinoma_Homo sapiens_hsa052170.33784160
122Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.33592926
123Fatty acid elongation_Homo sapiens_hsa000620.32367742
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32063386
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31657312
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31380367
127Endocytosis_Homo sapiens_hsa041440.30141306
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30071704
129Prostate cancer_Homo sapiens_hsa052150.29242180
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29023073
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28705807
132RNA transport_Homo sapiens_hsa030130.28671624
133Inositol phosphate metabolism_Homo sapiens_hsa005620.28601988
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28334663
135Long-term potentiation_Homo sapiens_hsa047200.28305371
136Renin-angiotensin system_Homo sapiens_hsa046140.28112407
137VEGF signaling pathway_Homo sapiens_hsa043700.27845274
138Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27450724
139Dilated cardiomyopathy_Homo sapiens_hsa054140.26837543
140Malaria_Homo sapiens_hsa051440.26271618
141RNA degradation_Homo sapiens_hsa030180.26224914
142Peroxisome_Homo sapiens_hsa041460.26221149
143Pancreatic secretion_Homo sapiens_hsa049720.25630867
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23322239
145ABC transporters_Homo sapiens_hsa020100.22161929
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21943975
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21521002
148Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20606695
149Tyrosine metabolism_Homo sapiens_hsa003500.19819043
150Gastric acid secretion_Homo sapiens_hsa049710.19792590
151Insulin signaling pathway_Homo sapiens_hsa049100.18598961
152N-Glycan biosynthesis_Homo sapiens_hsa005100.18271816
153cAMP signaling pathway_Homo sapiens_hsa040240.17008815

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