ODF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is localized in the outer dense fibers of the tails of mature sperm. This protein is thought to have some important role in the sperm tail. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.83359007
2epithelial cilium movement (GO:0003351)9.78404870
3spermatid development (GO:0007286)9.76423636
4motile cilium assembly (GO:0044458)9.49961043
5piRNA metabolic process (GO:0034587)9.22080923
6reproduction (GO:0000003)8.85191636
7regulation of cilium movement (GO:0003352)8.36386250
8male meiosis (GO:0007140)8.28982056
9cilium movement (GO:0003341)8.16594394
10synaptonemal complex organization (GO:0070193)8.13624311
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.95058412
12synaptonemal complex assembly (GO:0007130)7.84254958
13single fertilization (GO:0007338)7.21821538
14negative regulation of inclusion body assembly (GO:0090084)7.18974581
15sperm capacitation (GO:0048240)6.85834717
16* spermatogenesis (GO:0007283)6.53207519
17* male gamete generation (GO:0048232)6.50801228
18fertilization (GO:0009566)6.33169323
19organic cation transport (GO:0015695)6.11468968
20* gamete generation (GO:0007276)5.97322030
21DNA methylation involved in gamete generation (GO:0043046)5.92157622
22microtubule depolymerization (GO:0007019)5.85315754
23regulation of inclusion body assembly (GO:0090083)5.84009062
24male meiosis I (GO:0007141)5.76137769
25germ cell development (GO:0007281)5.54851887
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.45519615
27chromosome organization involved in meiosis (GO:0070192)5.39341642
28calcium ion-dependent exocytosis (GO:0017156)5.28724423
29ventricular system development (GO:0021591)5.27229724
30seminiferous tubule development (GO:0072520)5.18704984
31regulation of microtubule-based movement (GO:0060632)4.96399128
32meiotic nuclear division (GO:0007126)4.90525181
33cell recognition (GO:0008037)4.88864428
34microtubule severing (GO:0051013)4.75885007
35chromosome condensation (GO:0030261)4.68995884
36* multicellular organismal reproductive process (GO:0048609)4.68669311
37meiosis I (GO:0007127)4.64138639
38DNA packaging (GO:0006323)4.52490592
39left/right pattern formation (GO:0060972)4.42618871
40glycerol ether metabolic process (GO:0006662)4.35834197
41spermatid nucleus differentiation (GO:0007289)4.35104222
42meiotic cell cycle (GO:0051321)4.15472985
43chaperone-mediated protein complex assembly (GO:0051131)4.04073973
44ether metabolic process (GO:0018904)4.02516662
45protein localization to cilium (GO:0061512)3.96484399
46genitalia morphogenesis (GO:0035112)3.92752166
47* multicellular organismal development (GO:0007275)3.78368414
48protein polyglutamylation (GO:0018095)3.66485218
49monoubiquitinated protein deubiquitination (GO:0035520)3.50634462
50single strand break repair (GO:0000012)3.46681618
51sexual reproduction (GO:0019953)3.39391136
52protein refolding (GO:0042026)3.33077733
53regulation of spindle checkpoint (GO:0090231)3.31416338
54amino-acid betaine transport (GO:0015838)3.30971093
55carnitine transport (GO:0015879)3.30971093
56sequestering of actin monomers (GO:0042989)3.29724998
57gene silencing by RNA (GO:0031047)3.29220517
58intraciliary transport (GO:0042073)3.26061068
59carnitine transmembrane transport (GO:1902603)3.21072884
60meiotic cell cycle process (GO:1903046)3.19649252
61mitotic sister chromatid cohesion (GO:0007064)3.16313840
62synapsis (GO:0007129)3.15143704
63axoneme assembly (GO:0035082)3.13506675
64negative regulation of organelle assembly (GO:1902116)3.07754969
65protein K11-linked deubiquitination (GO:0035871)3.04373235
66microtubule-based movement (GO:0007018)3.03338100
67glycolytic process (GO:0006096)3.02554378
68polyol catabolic process (GO:0046174)3.02022440
69alditol metabolic process (GO:0019400)3.01810159
70nucleoside diphosphate phosphorylation (GO:0006165)3.00222889
71nucleus organization (GO:0006997)2.96413676
72microtubule polymerization or depolymerization (GO:0031109)2.95258694
73lactate metabolic process (GO:0006089)2.94945879
74cilium organization (GO:0044782)2.92979540
75interferon-gamma secretion (GO:0072643)2.86575410
76cilium morphogenesis (GO:0060271)2.78198164
77cilium assembly (GO:0042384)2.77969885
78cellular component assembly involved in morphogenesis (GO:0010927)2.75180400
79GTP biosynthetic process (GO:0006183)2.73804920
80regulation of meiosis I (GO:0060631)2.70105172
81gene silencing (GO:0016458)2.66516548
82RNA localization (GO:0006403)2.61226315
83regulation of cilium assembly (GO:1902017)2.61128928
84peptidyl-glutamic acid modification (GO:0018200)2.58169134
85glycerol metabolic process (GO:0006071)2.57405983
86regulation of centriole replication (GO:0046599)2.53860682
87nuclear pore complex assembly (GO:0051292)2.49676727
88positive regulation of macrophage activation (GO:0043032)2.47662684
89sperm motility (GO:0030317)13.4458895
90fusion of sperm to egg plasma membrane (GO:0007342)12.9139799
91acrosome reaction (GO:0007340)11.6738786
92cilium or flagellum-dependent cell motility (GO:0001539)11.4747186
93acrosome assembly (GO:0001675)11.4056178
94sperm-egg recognition (GO:0035036)11.2827201
95cell wall macromolecule metabolic process (GO:0044036)11.0206829
96cell wall macromolecule catabolic process (GO:0016998)11.0206829
97binding of sperm to zona pellucida (GO:0007339)10.4927239
98multicellular organism reproduction (GO:0032504)10.4113463
99axonemal dynein complex assembly (GO:0070286)10.2963187
100cell-cell recognition (GO:0009988)10.0925463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.82960914
2EZH2_22144423_ChIP-Seq_EOC_Human5.33543331
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.29755815
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.04769539
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.71328592
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.66502987
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49597170
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.34780133
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.28774100
10VDR_22108803_ChIP-Seq_LS180_Human2.26056489
11ZNF274_21170338_ChIP-Seq_K562_Hela2.23955222
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.18619729
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09416605
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.01976076
15ELK4_26923725_Chip-Seq_MESODERM_Mouse1.85262744
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76608024
17FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68424060
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67319873
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.65634774
20STAT1_17558387_ChIP-Seq_HELA_Human1.62900928
21TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.62389670
22SOX2_22085726_ChIP-Seq_NPCs_Mouse1.55298921
23WDR5_24793694_ChIP-Seq_LNCAP_Human1.54333669
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53813110
25MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49960644
26GATA3_21867929_ChIP-Seq_CD8_Mouse1.46885376
27RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43238202
28* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.42679291
29CBP_20019798_ChIP-Seq_JUKART_Human1.40357671
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40357671
31TAL1_26923725_Chip-Seq_HPCs_Mouse1.38082168
32REST_21632747_ChIP-Seq_MESCs_Mouse1.36276289
33FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34501552
34KAP1_22055183_ChIP-Seq_ESCs_Mouse1.29922773
35* KDM2B_26808549_Chip-Seq_REH_Human1.29076337
36SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27811346
37PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27444294
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.26044375
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21975842
40PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21751200
41* LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.21236962
42* P53_21459846_ChIP-Seq_SAOS-2_Human1.20910504
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19358199
44RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18896363
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.17138703
46SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16706673
47FLI1_21867929_ChIP-Seq_TH2_Mouse1.16668408
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14736503
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14736503
50CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13823884
51GF1_26923725_Chip-Seq_HPCs_Mouse1.13563687
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12414906
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12318659
54* GATA3_21867929_ChIP-Seq_TH1_Mouse1.11745150
55SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09353523
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07942452
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07555991
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06894256
59ERG_20517297_ChIP-Seq_VCAP_Human1.06049851
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05822436
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05613777
62CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04726489
63RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04553795
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.04532630
65PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04317383
66RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04144930
67SPI1_26923725_Chip-Seq_HPCs_Mouse1.03111619
68RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02193037
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.02155423
70ESET_19884257_ChIP-Seq_ESCs_Mouse0.99762954
71* MYC_27129775_Chip-Seq_CORNEA_Mouse0.97847383
72NANOG_18555785_Chip-Seq_ESCs_Mouse0.97795893
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97284530
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96449653
75TET1_21451524_ChIP-Seq_MESCs_Mouse0.95601899
76RARA_24833708_ChIP-Seq_LIVER_Mouse0.95237338
77EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94848331
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94656712
79GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94382818
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93039477
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92183989
82OCT4_18555785_Chip-Seq_ESCs_Mouse0.92083111
83LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91113434
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90404913
85FLI1_21867929_ChIP-Seq_CD8_Mouse0.90184364
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89918750
87RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89649939
88SOX2_21211035_ChIP-Seq_LN229_Human0.89512932
89CTCF_20526341_ChIP-Seq_ESCs_Human0.89343125
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89338642
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89310633
92P53_22387025_ChIP-Seq_ESCs_Mouse0.89139139
93RNF2_27304074_Chip-Seq_NSC_Mouse0.88717070
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.88272448
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87869653
96JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87866402
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87545571
98SOX11_22085726_ChIP-Seq_ESNs_Mouse0.87201337
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87104482
100TAF15_26573619_Chip-Seq_HEK293_Human0.86404528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.06498574
2MP0001929_abnormal_gametogenesis5.59490160
3MP0008877_abnormal_DNA_methylation4.83468619
4MP0002210_abnormal_sex_determination3.63668545
5MP0002161_abnormal_fertility/fecundity3.30019657
6MP0001145_abnormal_male_reproductive3.07019331
7MP0000653_abnormal_sex_gland2.65081695
8MP0002653_abnormal_ependyma_morphology2.42912521
9MP0005670_abnormal_white_adipose2.41870851
10MP0005410_abnormal_fertilization16.0622623
11MP0002160_abnormal_reproductive_system1.87432845
12MP0003646_muscle_fatigue1.64219897
13MP0005623_abnormal_meninges_morphology1.50214912
14MP0004233_abnormal_muscle_weight1.38208872
15MP0002282_abnormal_trachea_morphology1.19420395
16MP0001984_abnormal_olfaction1.10347773
17MP0001765_abnormal_ion_homeostasis1.08338248
18MP0005647_abnormal_sex_gland0.99708891
19MP0008057_abnormal_DNA_replication0.96493364
20MP0008058_abnormal_DNA_repair0.95777575
21MP0008995_early_reproductive_senescence0.95122987
22MP0005389_reproductive_system_phenotype0.92790946
23MP0009046_muscle_twitch0.86842503
24MP0003011_delayed_dark_adaptation0.84299551
25MP0002234_abnormal_pharynx_morphology0.78126467
26MP0010094_abnormal_chromosome_stability0.71611211
27MP0003115_abnormal_respiratory_system0.69551684
28MP0005377_hearing/vestibular/ear_phenot0.69076603
29MP0003878_abnormal_ear_physiology0.69076603
30MP0000569_abnormal_digit_pigmentation0.66908034
31MP0003786_premature_aging0.58661925
32MP0005636_abnormal_mineral_homeostasis0.56722708
33MP0003329_amyloid_beta_deposits0.56195525
34MP0000358_abnormal_cell_content/0.56173867
35MP0003950_abnormal_plasma_membrane0.53907229
36MP0005397_hematopoietic_system_phenotyp0.53475160
37MP0001545_abnormal_hematopoietic_system0.53475160
38MP0008007_abnormal_cellular_replicative0.52594133
39MP0009278_abnormal_bone_marrow0.52023185
40MP0005666_abnormal_adipose_tissue0.48747190
41MP0003699_abnormal_female_reproductive0.47873071
42MP0004036_abnormal_muscle_relaxation0.46800145
43MP0001324_abnormal_eye_pigmentation0.42137613
44MP0002928_abnormal_bile_duct0.41240329
45MP0002269_muscular_atrophy0.41062450
46MP0005253_abnormal_eye_physiology0.39590820
47MP0006036_abnormal_mitochondrial_physio0.39278680
48MP0001293_anophthalmia0.39130684
49MP0003111_abnormal_nucleus_morphology0.37952433
50MP0002736_abnormal_nociception_after0.36764089
51MP0001764_abnormal_homeostasis0.36657061
52MP0005551_abnormal_eye_electrophysiolog0.36338646
53MP0004808_abnormal_hematopoietic_stem0.33828962
54MP0000534_abnormal_ureter_morphology0.33481183
55MP0004811_abnormal_neuron_physiology0.33328677
56MP0001119_abnormal_female_reproductive0.31933005
57MP0001730_embryonic_growth_arrest0.31650868
58MP0005391_vision/eye_phenotype0.31151861
59MP0003879_abnormal_hair_cell0.30816381
60MP0009115_abnormal_fat_cell0.29583381
61MP0008961_abnormal_basal_metabolism0.28913351
62MP0000751_myopathy0.28679663
63MP0002971_abnormal_brown_adipose0.28575229
64MP0001727_abnormal_embryo_implantation0.27737956
65MP0001661_extended_life_span0.27715937
66MP0003633_abnormal_nervous_system0.27329849
67MP0000604_amyloidosis0.26785350
68MP0003861_abnormal_nervous_system0.26474561
69MP0004019_abnormal_vitamin_homeostasis0.25989322
70MP0010307_abnormal_tumor_latency0.25743608
71MP0002152_abnormal_brain_morphology0.25729424
72MP0004133_heterotaxia0.25691675
73MP0003942_abnormal_urinary_system0.25639332
74MP0004134_abnormal_chest_morphology0.25307438
75MP0003045_fibrosis0.24701336
76MP0006035_abnormal_mitochondrial_morpho0.22365389
77MP0004043_abnormal_pH_regulation0.21888420
78MP0004742_abnormal_vestibular_system0.21867944
79MP0003631_nervous_system_phenotype0.21743308
80MP0003787_abnormal_imprinting0.21686508
81MP0002169_no_abnormal_phenotype0.21103937
82MP0002873_normal_phenotype0.20858929
83MP0003948_abnormal_gas_homeostasis0.20206779
84MP0004270_analgesia0.20103629
85MP0001968_abnormal_touch/_nociception0.19697330
86MP0000313_abnormal_cell_death0.19091087
87MP0003936_abnormal_reproductive_system0.18069471
88MP0002092_abnormal_eye_morphology0.17487376
89MP0002229_neurodegeneration0.16696445
90MP0001440_abnormal_grooming_behavior0.16364620
91MP0002572_abnormal_emotion/affect_behav0.16288724
92MP0002084_abnormal_developmental_patter0.15980508
93MP0005423_abnormal_somatic_nervous0.15701659
94MP0002295_abnormal_pulmonary_circulatio0.15347317
95MP0000001_mammalian_phenotype0.14150198
96MP0001849_ear_inflammation0.14035775
97MP0003959_abnormal_lean_body0.13831234
98MP0002102_abnormal_ear_morphology0.13789389
99MP0005375_adipose_tissue_phenotype0.13248371
100MP0002822_catalepsy0.12847884

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.34531020
2Abnormal respiratory motile cilium morphology (HP:0005938)9.07819077
3Abnormal respiratory epithelium morphology (HP:0012253)9.07819077
4Rhinitis (HP:0012384)7.75036985
5Chronic bronchitis (HP:0004469)7.38261460
6Abnormal ciliary motility (HP:0012262)7.33342388
7Infertility (HP:0000789)6.88673097
8Nasal polyposis (HP:0100582)6.44670921
9Abnormality of the nasal mucosa (HP:0000433)5.29527202
10Bronchitis (HP:0012387)4.52845660
11Bronchiectasis (HP:0002110)4.51728971
12Nephronophthisis (HP:0000090)4.47307591
13Male infertility (HP:0003251)4.15884899
14Abnormality of the renal medulla (HP:0100957)3.38469057
15Abnormal spermatogenesis (HP:0008669)3.32627580
16Recurrent otitis media (HP:0000403)3.29153141
17Recurrent sinusitis (HP:0011108)3.23332164
18Gonadotropin excess (HP:0000837)2.94280319
19Tubulointerstitial nephritis (HP:0001970)2.87022009
20Abnormality of the lower motor neuron (HP:0002366)2.82142096
21Tubular atrophy (HP:0000092)2.68470766
22Abnormality of midbrain morphology (HP:0002418)2.65355207
23Molar tooth sign on MRI (HP:0002419)2.65355207
24Recurrent bronchitis (HP:0002837)2.62568461
25Tubulointerstitial abnormality (HP:0001969)2.53286339
26Impulsivity (HP:0100710)2.50293345
27Medial flaring of the eyebrow (HP:0010747)2.42633282
28Amyotrophic lateral sclerosis (HP:0007354)2.30008688
29Azoospermia (HP:0000027)2.28673201
30Abnormal gallbladder physiology (HP:0012438)2.14227463
31Cholecystitis (HP:0001082)2.14227463
32Tubulointerstitial fibrosis (HP:0005576)2.10184411
33Fibular hypoplasia (HP:0003038)2.07610370
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1616355
35Absent/shortened dynein arms (HP:0200106)13.1027564
36Dynein arm defect of respiratory motile cilia (HP:0012255)13.1027564
37Stage 5 chronic kidney disease (HP:0003774)1.97483485
38Postaxial foot polydactyly (HP:0001830)1.96217429
39Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93240298
40Abnormal drinking behavior (HP:0030082)1.92515907
41Polydipsia (HP:0001959)1.92515907
42Spastic tetraparesis (HP:0001285)1.90102041
43Dyschromatopsia (HP:0007641)1.81615151
44Impaired proprioception (HP:0010831)1.81503905
45Abnormality of the renal cortex (HP:0011035)1.81235781
46Congenital hepatic fibrosis (HP:0002612)1.77695784
47Oculomotor apraxia (HP:0000657)1.73541686
48Short ribs (HP:0000773)1.70434106
49Abnormality of renal excretion (HP:0011036)1.66603365
50Heterotopia (HP:0002282)1.64304407
51Choroideremia (HP:0001139)1.63675326
52Renal dysplasia (HP:0000110)1.62766898
53Abnormality of dentin (HP:0010299)1.61664205
54Abnormality of permanent molar morphology (HP:0011071)1.58925153
55Abnormality of the dental root (HP:0006486)1.58925153
56Taurodontia (HP:0000679)1.58925153
57Bell-shaped thorax (HP:0001591)1.56897935
58Postaxial hand polydactyly (HP:0001162)1.52020673
59Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.51914795
60Absent epiphyses (HP:0010577)1.51914795
61Absent frontal sinuses (HP:0002688)1.50751450
62Decreased central vision (HP:0007663)1.50411538
63Upper motor neuron abnormality (HP:0002127)1.48608102
64Bile duct proliferation (HP:0001408)1.47260722
65Abnormal biliary tract physiology (HP:0012439)1.47260722
66Abnormality of molar morphology (HP:0011070)1.46562965
67Abnormality of molar (HP:0011077)1.46562965
68Abnormality of the dental pulp (HP:0006479)1.45716541
69J-shaped sella turcica (HP:0002680)1.44505229
70Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.44146489
71Chronic sinusitis (HP:0011109)1.44078647
72Facial cleft (HP:0002006)1.43923137
73Neurofibrillary tangles (HP:0002185)1.40348574
74Deformed sella turcica (HP:0002681)1.39737748
75Abnormal urine output (HP:0012590)1.39220098
76Broad distal phalanx of finger (HP:0009836)1.36542760
77Hemorrhage of the eye (HP:0011885)1.35444781
78Aplasia/Hypoplasia of the lens (HP:0008063)1.35427775
79Cystic liver disease (HP:0006706)1.35104148
80Supernumerary spleens (HP:0009799)1.33290174
81Microglossia (HP:0000171)1.32268385
82Short thorax (HP:0010306)1.32046602
83Degeneration of anterior horn cells (HP:0002398)1.29785575
84Abnormality of the anterior horn cell (HP:0006802)1.29785575
85Exercise-induced myalgia (HP:0003738)1.29292066
86Nephropathy (HP:0000112)1.28717535
87Aplasia/Hypoplasia of the fibula (HP:0006492)1.26746974
88Cerebellar dysplasia (HP:0007033)1.25371106
89Short femoral neck (HP:0100864)1.25047682
90Decreased electroretinogram (ERG) amplitude (HP:0000654)1.24829081
91Polyuria (HP:0000103)1.22879949
92Easy fatigability (HP:0003388)1.22206229
93Median cleft lip (HP:0000161)1.22017248
94Congenital primary aphakia (HP:0007707)1.21148647
95Congenital malformation of the right heart (HP:0011723)1.21136595
96Double outlet right ventricle (HP:0001719)1.21136595
97Gait imbalance (HP:0002141)1.21132955
98Abnormality of ocular smooth pursuit (HP:0000617)1.20028689
99Bundle branch block (HP:0011710)1.17374259
100Short nail (HP:0001799)1.17354475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.51959353
2PDK38.51959353
3TESK15.84125309
4PDK25.51149871
5PRKD34.65496481
6ICK4.14146620
7PTK2B2.39864755
8WNK42.29747759
9STK392.16844169
10PNCK2.14366000
11NEK21.81682736
12STK381.73537196
13DYRK1B1.32186437
14PDK11.07498561
15MAPK151.00814003
16WNK10.98077185
17TYRO30.95407539
18DYRK30.82850110
19CCNB10.81336594
20PASK0.78959871
21PINK10.74046525
22STK30.73426888
23IRAK10.65868384
24TTK0.59353902
25PDPK10.57606378
26EEF2K0.51183690
27RIPK40.50012417
28TESK20.48644422
29CAMK1G0.47887380
30CDC70.47737423
31NTRK20.47727383
32CHEK20.46390578
33CHEK10.41143034
34PRKCG0.37387852
35MAP2K60.37170290
36LMTK20.36792757
37MUSK0.35322497
38ATR0.34864686
39WEE10.33496898
40IRAK20.33055316
41PAK10.32748075
42STK38L0.29729879
43CAMKK10.28797250
44ATM0.28035692
45PAK20.26026575
46MTOR0.25971431
47MARK20.25895076
48PRKAA10.20380255
49MAPKAPK50.18364431
50RPS6KB10.17794204
51PAK40.17288247
52MAP3K40.16237109
53MAP3K100.15268441
54PRKCZ0.13948020
55PLK10.13826837
56PLK40.13720931
57WNK30.13212245
58NEK60.12094326
59CDK30.12052229
60CDK150.10236992
61BRAF0.10185923
62PRKCQ0.09999783
63CSF1R0.09102125
64BMPR1B0.08161445
65CDK180.08009280
66CDK11A0.07354588
67CDK120.05762309
68PAK60.05527705
69CSNK2A10.05139105
70CSNK1D0.04762023
71RPS6KA10.04463767
72GSK3B0.03854466
73CDK140.03692050
74PRKACG0.02995218
75MAPK80.02971524
76STK110.02858529
77CDK10.02533720
78PRKG10.02265420
79PRKCB0.01511601
80CDK20.01281224
81CAMK2A0.00436321
82BRSK20.00272399
83TAOK10.00175305
84PRKG20.00036537
85AURKA-0.0416541
86CDK6-0.0395894
87PRKCD-0.0394579
88CLK1-0.0370811
89ZAP70-0.0349404
90PIM1-0.0300137
91CSNK2A2-0.0228287
92PRKDC-0.0216698
93RPS6KA3-0.0164091
94EGFR-0.0156502
95PRKACB-0.0146551
96BRSK1-0.0115786
97MAP2K7-0.0102153
98PRKCA-0.0098596
99MARK3-0.0083970
100STK10-0.0032749

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.38890181
2Vitamin B6 metabolism_Homo sapiens_hsa007504.32981037
3Fatty acid biosynthesis_Homo sapiens_hsa000614.06492621
4Pyruvate metabolism_Homo sapiens_hsa006203.97263238
5Propanoate metabolism_Homo sapiens_hsa006402.99925956
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.87493812
7Glucagon signaling pathway_Homo sapiens_hsa049222.81440794
8Linoleic acid metabolism_Homo sapiens_hsa005912.76797929
9Basal transcription factors_Homo sapiens_hsa030222.35076473
10Selenocompound metabolism_Homo sapiens_hsa004502.30290511
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.24758093
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.11601194
13Dorso-ventral axis formation_Homo sapiens_hsa043202.10473922
14Glycerolipid metabolism_Homo sapiens_hsa005611.97388998
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.91987543
16Oocyte meiosis_Homo sapiens_hsa041141.83787457
17Pentose phosphate pathway_Homo sapiens_hsa000301.83316116
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75631404
19Amphetamine addiction_Homo sapiens_hsa050311.74759274
20PPAR signaling pathway_Homo sapiens_hsa033201.73197422
21Fanconi anemia pathway_Homo sapiens_hsa034601.64002708
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.57807914
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.56261107
24Fructose and mannose metabolism_Homo sapiens_hsa000511.51060195
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45316093
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.36433636
27Cardiac muscle contraction_Homo sapiens_hsa042601.35351391
28Antigen processing and presentation_Homo sapiens_hsa046121.35100049
29Renin secretion_Homo sapiens_hsa049241.35003680
30Carbon metabolism_Homo sapiens_hsa012001.34755441
31Fat digestion and absorption_Homo sapiens_hsa049751.34377434
32Huntingtons disease_Homo sapiens_hsa050161.33209423
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30759722
34Ether lipid metabolism_Homo sapiens_hsa005651.25338497
35Fatty acid metabolism_Homo sapiens_hsa012121.23389527
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.22002696
37Mineral absorption_Homo sapiens_hsa049781.17577490
38Fatty acid degradation_Homo sapiens_hsa000711.14127162
39mRNA surveillance pathway_Homo sapiens_hsa030151.13081734
40Long-term potentiation_Homo sapiens_hsa047201.00222129
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92940734
42Purine metabolism_Homo sapiens_hsa002300.92147511
43RNA transport_Homo sapiens_hsa030130.91439790
44Collecting duct acid secretion_Homo sapiens_hsa049660.88839042
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84915871
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82214300
47Glutathione metabolism_Homo sapiens_hsa004800.78957900
48Biosynthesis of amino acids_Homo sapiens_hsa012300.77700754
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77272015
50Estrogen signaling pathway_Homo sapiens_hsa049150.76962311
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75230765
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74988233
53Hedgehog signaling pathway_Homo sapiens_hsa043400.74050366
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.72706262
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72652418
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70038372
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.68314556
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66086446
59ABC transporters_Homo sapiens_hsa020100.65860301
60Insulin secretion_Homo sapiens_hsa049110.65767206
61Arachidonic acid metabolism_Homo sapiens_hsa005900.65604421
62Chemical carcinogenesis_Homo sapiens_hsa052040.63029766
63Calcium signaling pathway_Homo sapiens_hsa040200.60012846
64Thyroid hormone synthesis_Homo sapiens_hsa049180.56387279
65VEGF signaling pathway_Homo sapiens_hsa043700.53590434
66Bile secretion_Homo sapiens_hsa049760.53547228
67Legionellosis_Homo sapiens_hsa051340.53149235
68Synaptic vesicle cycle_Homo sapiens_hsa047210.49288922
69Systemic lupus erythematosus_Homo sapiens_hsa053220.48614294
70AMPK signaling pathway_Homo sapiens_hsa041520.47407211
71Endocytosis_Homo sapiens_hsa041440.44940460
72Salivary secretion_Homo sapiens_hsa049700.43696964
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43654167
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.42096445
75Pancreatic secretion_Homo sapiens_hsa049720.39866184
76Inositol phosphate metabolism_Homo sapiens_hsa005620.37276382
77Gastric acid secretion_Homo sapiens_hsa049710.36642617
78Circadian entrainment_Homo sapiens_hsa047130.36402364
79Taste transduction_Homo sapiens_hsa047420.34392440
80Alcoholism_Homo sapiens_hsa050340.33636404
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33058909
82Metabolic pathways_Homo sapiens_hsa011000.31253543
83Protein digestion and absorption_Homo sapiens_hsa049740.30472092
84cAMP signaling pathway_Homo sapiens_hsa040240.29373438
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28251562
86Renin-angiotensin system_Homo sapiens_hsa046140.28208654
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27246750
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26502206
89Olfactory transduction_Homo sapiens_hsa047400.23383971
90B cell receptor signaling pathway_Homo sapiens_hsa046620.22877068
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22043175
92N-Glycan biosynthesis_Homo sapiens_hsa005100.21930432
93Cocaine addiction_Homo sapiens_hsa050300.21441058
94Pyrimidine metabolism_Homo sapiens_hsa002400.20628691
95Wnt signaling pathway_Homo sapiens_hsa043100.18989239
96Glutamatergic synapse_Homo sapiens_hsa047240.17691430
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17131967
98HIF-1 signaling pathway_Homo sapiens_hsa040660.09910317
99Dopaminergic synapse_Homo sapiens_hsa047280.09780896
100Salmonella infection_Homo sapiens_hsa051320.09310601

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