OFD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located on the X chromosome and encodes a centrosomal protein. A knockout mouse model has been used to study the effect of mutations in this gene. The mouse gene is also located on the X chromosome, however, unlike the human gene it is not subject to X inactivation. Mutations in this gene are associated with oral-facial-digital syndrome type I and Simpson-Golabi-Behmel syndrome type 2. Many pseudogenes have been identified; a single pseudogene is found on chromosome 5 while as many as fifteen have been found on the Y chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.29016765
2nuclear pore organization (GO:0006999)5.07859550
3mitotic sister chromatid cohesion (GO:0007064)4.53226948
4dosage compensation (GO:0007549)4.52769949
5pore complex assembly (GO:0046931)4.43569233
6positive regulation of histone H3-K4 methylation (GO:0051571)4.32868589
7piRNA metabolic process (GO:0034587)4.27107939
8kinetochore organization (GO:0051383)4.13718831
9mitotic metaphase plate congression (GO:0007080)4.04237923
10mitotic nuclear envelope disassembly (GO:0007077)4.02953944
11mitotic chromosome condensation (GO:0007076)4.01004633
12protein localization to kinetochore (GO:0034501)3.94189434
13membrane disassembly (GO:0030397)3.83962386
14nuclear envelope disassembly (GO:0051081)3.83962386
15regulation of meiosis I (GO:0060631)3.83162407
16histone H3-K4 trimethylation (GO:0080182)3.77202432
17DNA methylation involved in gamete generation (GO:0043046)3.75115099
18DNA replication-independent nucleosome assembly (GO:0006336)3.74167867
19DNA replication-independent nucleosome organization (GO:0034724)3.74167867
20regulation of nuclear cell cycle DNA replication (GO:0033262)3.73042166
21DNA unwinding involved in DNA replication (GO:0006268)3.72647685
22histone H2A monoubiquitination (GO:0035518)3.69221550
23meiotic cell cycle (GO:0051321)3.68586768
24DNA replication checkpoint (GO:0000076)3.68528779
25kinetochore assembly (GO:0051382)3.67584548
26telomere maintenance via semi-conservative replication (GO:0032201)3.64383253
27metaphase plate congression (GO:0051310)3.62780194
28replication fork processing (GO:0031297)3.62495883
29reciprocal meiotic recombination (GO:0007131)3.62369365
30reciprocal DNA recombination (GO:0035825)3.62369365
31negative regulation of histone methylation (GO:0031061)3.62267399
32telomere maintenance via recombination (GO:0000722)3.61000771
33regulation of DNA methylation (GO:0044030)3.60491804
34histone H3-K9 methylation (GO:0051567)3.60216017
35mitotic recombination (GO:0006312)3.59776316
36meiotic chromosome segregation (GO:0045132)3.59528403
37* centriole replication (GO:0007099)3.58173177
38regulation of RNA export from nucleus (GO:0046831)3.57914180
39chromatin remodeling at centromere (GO:0031055)3.57616673
40maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.55264408
41DNA strand elongation involved in DNA replication (GO:0006271)3.52343511
42chromatin assembly or disassembly (GO:0006333)3.52267591
43sister chromatid cohesion (GO:0007062)3.51396599
44heterochromatin organization (GO:0070828)3.49391446
45CENP-A containing nucleosome assembly (GO:0034080)3.46719349
46synapsis (GO:0007129)3.41530289
47retinal cone cell development (GO:0046549)3.40949855
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.37493824
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.37493824
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.37493824
51DNA strand elongation (GO:0022616)3.37446950
52protein localization to chromosome, centromeric region (GO:0071459)3.36070455
53male meiosis I (GO:0007141)3.35897143
54sister chromatid segregation (GO:0000819)3.35226537
55DNA replication initiation (GO:0006270)3.34942044
56telomere maintenance via telomerase (GO:0007004)3.32962436
57positive regulation of histone methylation (GO:0031062)3.32540869
58mitotic sister chromatid segregation (GO:0000070)3.31832406
59protein K6-linked ubiquitination (GO:0085020)3.30359264
60attachment of spindle microtubules to kinetochore (GO:0008608)3.29564634
61DNA geometric change (GO:0032392)3.28096511
62positive regulation of chromosome segregation (GO:0051984)3.27925399
63regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27093909
64establishment of chromosome localization (GO:0051303)3.26949826
65regulation of histone H3-K9 methylation (GO:0051570)3.26359166
66DNA duplex unwinding (GO:0032508)3.25436106
67protein neddylation (GO:0045116)3.24030134
68regulation of sister chromatid cohesion (GO:0007063)3.19712232
69nucleotide-excision repair, DNA gap filling (GO:0006297)3.15914203
70regulation of acrosome reaction (GO:0060046)3.14074189
71DNA replication-dependent nucleosome assembly (GO:0006335)3.12134187
72DNA replication-dependent nucleosome organization (GO:0034723)3.12134187
73regulation of helicase activity (GO:0051095)3.09807792
74histone exchange (GO:0043486)3.09252084
75regulation of spindle organization (GO:0090224)3.08109554
76folic acid-containing compound biosynthetic process (GO:0009396)3.07985005
77telomere maintenance via telomere lengthening (GO:0010833)3.06839869
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06026859
79gene silencing by RNA (GO:0031047)3.05460315
80histone H3-K9 modification (GO:0061647)3.05436179
81nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.05298798
82chromosome organization involved in meiosis (GO:0070192)3.05180092
83cilium or flagellum-dependent cell motility (GO:0001539)3.04842054
84negative regulation of DNA-dependent DNA replication (GO:2000104)3.04519328
85meiosis I (GO:0007127)3.04246532
86chromatin assembly (GO:0031497)3.03679923
87oocyte development (GO:0048599)3.03369743
88intraciliary transport (GO:0042073)3.02874391
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.02849578
90regulation of mitotic spindle checkpoint (GO:1903504)3.02849578
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99764290
92regulation of double-strand break repair via homologous recombination (GO:0010569)2.99631791
93male meiosis (GO:0007140)2.98944627
94peptidyl-lysine methylation (GO:0018022)2.98859813
95DNA topological change (GO:0006265)2.98752495
96regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.98209496
97monoubiquitinated protein deubiquitination (GO:0035520)2.98102827
98mRNA transport (GO:0051028)2.95835764
99pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95619847
100regulation of nucleobase-containing compound transport (GO:0032239)2.94857730
101regulation of B cell receptor signaling pathway (GO:0050855)2.94442463
102pre-miRNA processing (GO:0031054)2.94370396
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.94125655
104* epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92748772
105regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92576456
106spindle checkpoint (GO:0031577)2.91774333
107histone H4-K12 acetylation (GO:0043983)2.91539170
108regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90990267
109RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90388707
110nuclear envelope organization (GO:0006998)2.88816431
111mRNA export from nucleus (GO:0006406)2.88788074
112regulation of chromosome segregation (GO:0051983)2.88766521
113protein localization to chromosome (GO:0034502)2.87977267
114ribosome assembly (GO:0042255)2.86769115
115multicellular organism reproduction (GO:0032504)2.85521328
116regulation of histone H3-K4 methylation (GO:0051569)2.85289757
117chromosome segregation (GO:0007059)2.85047218
118regulation of DNA endoreduplication (GO:0032875)2.83158188
119RNA export from nucleus (GO:0006405)2.81559720
120spindle assembly checkpoint (GO:0071173)2.79669091
121regulation of mitotic spindle organization (GO:0060236)2.79665798
122mitotic spindle checkpoint (GO:0071174)2.79436694
123DNA conformation change (GO:0071103)2.77124945
124somatic hypermutation of immunoglobulin genes (GO:0016446)2.76214150
125somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76214150
126negative regulation of chromosome segregation (GO:0051985)2.76046621
127telomere maintenance (GO:0000723)2.75816670
128regulation of histone methylation (GO:0031060)2.75557314
129auditory receptor cell differentiation (GO:0042491)2.75208405
130histone H2A ubiquitination (GO:0033522)2.74754851
131pyrimidine nucleotide catabolic process (GO:0006244)2.74578207
132telomere organization (GO:0032200)2.73828421
133ATP-dependent chromatin remodeling (GO:0043044)2.73523053
134DNA strand renaturation (GO:0000733)2.73000829
135histone mRNA catabolic process (GO:0071044)2.72888097
136peptidyl-lysine trimethylation (GO:0018023)2.72794490
137double-strand break repair via homologous recombination (GO:0000724)2.72375038
138* epithelial cilium movement (GO:0003351)2.72229535
139synaptonemal complex assembly (GO:0007130)2.69052867
140neural tube formation (GO:0001841)2.68738011
141translational termination (GO:0006415)2.68375351
142negative regulation of DNA recombination (GO:0045910)2.67624602
143recombinational repair (GO:0000725)2.66275802
144DNA deamination (GO:0045006)2.66256102
145meiotic cell cycle process (GO:1903046)2.63556342
146viral transcription (GO:0019083)2.62188167
147negative T cell selection (GO:0043383)2.60360755
148neuron fate determination (GO:0048664)2.59484929
149meiotic nuclear division (GO:0007126)2.59259463
150DNA synthesis involved in DNA repair (GO:0000731)2.58431706
151positive regulation of granulocyte differentiation (GO:0030854)2.57718536
152ribosomal small subunit assembly (GO:0000028)2.57326160
153regulation of female gonad development (GO:2000194)2.56819446
154* cilium movement (GO:0003341)2.56334564
155establishment of protein localization to Golgi (GO:0072600)2.56157427
156DNA methylation (GO:0006306)2.55657908
157DNA alkylation (GO:0006305)2.55657908
158respiratory chain complex IV assembly (GO:0008535)2.55307629
159genitalia morphogenesis (GO:0035112)2.55272920
160axonemal dynein complex assembly (GO:0070286)2.54700146
161DNA demethylation (GO:0080111)2.54133331
162negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.54038136
163DNA methylation or demethylation (GO:0044728)2.53817671
164intra-S DNA damage checkpoint (GO:0031573)2.51310779
165negative thymic T cell selection (GO:0045060)2.50971514
166regulation of chromatin silencing (GO:0031935)2.50492001
167mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49318059
168mitochondrial respiratory chain complex I assembly (GO:0032981)2.49318059
169NADH dehydrogenase complex assembly (GO:0010257)2.49318059
170transcription elongation from RNA polymerase I promoter (GO:0006362)2.48763084
171histone mRNA metabolic process (GO:0008334)2.46902137
172DNA double-strand break processing (GO:0000729)2.45584014
173regulation of cilium movement (GO:0003352)2.45571981
174female gamete generation (GO:0007292)2.43669749
175DNA-dependent DNA replication (GO:0006261)2.42799356
176protein complex biogenesis (GO:0070271)2.41701090
177positive regulation of humoral immune response (GO:0002922)2.40908302
178synaptonemal complex organization (GO:0070193)2.40479024
179DNA modification (GO:0006304)2.38249645
180seminiferous tubule development (GO:0072520)2.36790969
181protein targeting to Golgi (GO:0000042)2.36490278
182nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.33234387
183SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.33090241

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.33611656
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.93009978
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.38211349
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.43238563
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.23982027
6EZH2_22144423_ChIP-Seq_EOC_Human3.23766259
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.98813810
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89572446
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.77399869
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.75113560
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.44011865
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37560317
13AR_21909140_ChIP-Seq_LNCAP_Human2.28934804
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.28872096
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.25567225
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23123004
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23090057
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.18047922
19EWS_26573619_Chip-Seq_HEK293_Human2.15782722
20ZNF274_21170338_ChIP-Seq_K562_Hela2.15719259
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06754016
22FUS_26573619_Chip-Seq_HEK293_Human2.05579134
23MYC_22102868_ChIP-Seq_BL_Human2.03747950
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03203732
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02041094
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96254386
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95636160
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92335687
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91106663
30IGF1R_20145208_ChIP-Seq_DFB_Human1.89784158
31VDR_22108803_ChIP-Seq_LS180_Human1.86556467
32* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83901108
33VDR_23849224_ChIP-Seq_CD4+_Human1.77186192
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.73954113
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.70238286
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69823721
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65155824
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65084938
39SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.63172426
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62752749
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61895359
42GBX2_23144817_ChIP-Seq_PC3_Human1.61558085
43ER_23166858_ChIP-Seq_MCF-7_Human1.61098176
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.59376745
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.59009316
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56798381
47* ELK1_19687146_ChIP-ChIP_HELA_Human1.56298536
48FOXP3_21729870_ChIP-Seq_TREG_Human1.56245267
49* XRN2_22483619_ChIP-Seq_HELA_Human1.56028611
50KDM5A_27292631_Chip-Seq_BREAST_Human1.55630108
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54689432
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53820344
53CBP_20019798_ChIP-Seq_JUKART_Human1.53820344
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50927552
55* P300_19829295_ChIP-Seq_ESCs_Human1.49446232
56IRF1_19129219_ChIP-ChIP_H3396_Human1.49249637
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48760804
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48042650
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47446342
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.46102147
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45357339
62MYC_18940864_ChIP-ChIP_HL60_Human1.43211890
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43171658
64TAF15_26573619_Chip-Seq_HEK293_Human1.42228712
65GATA1_22025678_ChIP-Seq_K562_Human1.41583781
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41407739
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40749323
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40463130
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40442573
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.39978068
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39854153
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.39330524
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39270539
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37558858
75GABP_19822575_ChIP-Seq_HepG2_Human1.37065129
76DCP1A_22483619_ChIP-Seq_HELA_Human1.35602540
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35571583
78* TTF2_22483619_ChIP-Seq_HELA_Human1.34724570
79BCAT_22108803_ChIP-Seq_LS180_Human1.33925178
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33649226
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.33018024
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32948075
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32306001
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32040356
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31288355
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.30643865
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.30643865
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.30643865
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30333966
90E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30172510
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29342488
92TFEB_21752829_ChIP-Seq_HELA_Human1.29148698
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28702850
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28615773
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28171870
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27128148
97CIITA_25753668_ChIP-Seq_RAJI_Human1.26936409
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26107391
99PKCTHETA_26484144_Chip-Seq_BREAST_Human1.26047855
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24701041
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23012320
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21514841
103TP53_22573176_ChIP-Seq_HFKS_Human1.21361475
104TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20399536
105TCF4_23295773_ChIP-Seq_U87_Human1.19522677
106ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18880637
107SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17996977
108ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17465887
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17430917
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16802976
111* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16793673
112CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16115847
113GATA3_26560356_Chip-Seq_TH2_Human1.16030533
114FOXA1_25329375_ChIP-Seq_VCAP_Human1.15737871
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15737871
116STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14770926
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14311041
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14234652
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13635606
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12916742
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11850829
122RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11104134
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10053699
124TCF4_22108803_ChIP-Seq_LS180_Human1.09830270
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09661881
126AR_20517297_ChIP-Seq_VCAP_Human1.08182418
127FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07348713
128STAT3_23295773_ChIP-Seq_U87_Human1.07009591
129EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06313187
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06100997
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06100997
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05452369
133* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04158627
134TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04054491
135NANOG_19829295_ChIP-Seq_ESCs_Human1.03725106
136SOX2_19829295_ChIP-Seq_ESCs_Human1.03725106
137CRX_20693478_ChIP-Seq_RETINA_Mouse1.03461555
138MYB_26560356_Chip-Seq_TH1_Human1.02722724
139CHD1_26751641_Chip-Seq_LNCaP_Human1.02502909
140NANOG_21062744_ChIP-ChIP_HESCs_Human1.02310884
141PRDM14_20953172_ChIP-Seq_ESCs_Human1.02064865
142STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.01534104
143CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99277596
144TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99042349
145CDX2_22108803_ChIP-Seq_LS180_Human0.98450711
146AR_25329375_ChIP-Seq_VCAP_Human0.98421688
147TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97942113
148FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97731166
149NANOG_18555785_Chip-Seq_ESCs_Mouse0.97265573
150P53_22387025_ChIP-Seq_ESCs_Mouse0.96903991
151SMAD4_21799915_ChIP-Seq_A2780_Human0.96443497
152GATA3_26560356_Chip-Seq_TH1_Human0.95754327
153SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95394348
154* MYB_26560356_Chip-Seq_TH2_Human0.94606378
155RUNX2_22187159_ChIP-Seq_PCA_Human0.94233455
156ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93836849
157SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93703779
158SPI1_23547873_ChIP-Seq_NB4_Human0.91390650
159RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90645890
160ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90421613
161HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89840373
162DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88879706
163THAP11_20581084_ChIP-Seq_MESCs_Mouse0.85891176
164VDR_21846776_ChIP-Seq_THP-1_Human0.85698899
165SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84659236
166HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.82500114
167TCF7_22412390_ChIP-Seq_EML_Mouse0.80246452
168TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80016965
169GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79635434
170FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.79468122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.92368272
2MP0010094_abnormal_chromosome_stability3.78994437
3MP0003693_abnormal_embryo_hatching3.75829149
4MP0004957_abnormal_blastocyst_morpholog3.57090920
5MP0003111_abnormal_nucleus_morphology3.40702401
6MP0003077_abnormal_cell_cycle3.26186566
7MP0008877_abnormal_DNA_methylation3.22555869
8MP0008058_abnormal_DNA_repair2.77987992
9MP0008007_abnormal_cellular_replicative2.64282297
10MP0010352_gastrointestinal_tract_polyps2.54786616
11MP0002009_preneoplasia2.38589884
12MP0003787_abnormal_imprinting2.36752632
13MP0002138_abnormal_hepatobiliary_system2.32354885
14MP0000350_abnormal_cell_proliferation2.07761483
15MP0002877_abnormal_melanocyte_morpholog2.02557395
16MP0002396_abnormal_hematopoietic_system2.00713179
17MP0005075_abnormal_melanosome_morpholog1.90159818
18MP0003121_genomic_imprinting1.89778604
19MP0003890_abnormal_embryonic-extraembry1.87635630
20MP0000372_irregular_coat_pigmentation1.85411094
21MP0008932_abnormal_embryonic_tissue1.75008223
22MP0010307_abnormal_tumor_latency1.74792589
23MP0001730_embryonic_growth_arrest1.71557567
24* MP0002084_abnormal_developmental_patter1.66661999
25MP0003123_paternal_imprinting1.64066640
26MP0005076_abnormal_cell_differentiation1.61747573
27MP0005380_embryogenesis_phenotype1.60936518
28MP0001672_abnormal_embryogenesis/_devel1.60936518
29MP0000490_abnormal_crypts_of1.59637077
30MP0003786_premature_aging1.59117780
31MP0000631_abnormal_neuroendocrine_gland1.55719421
32* MP0001697_abnormal_embryo_size1.54832166
33MP0004808_abnormal_hematopoietic_stem1.50037987
34* MP0002085_abnormal_embryonic_tissue1.48141711
35MP0005646_abnormal_pituitary_gland1.46722663
36MP0001835_abnormal_antigen_presentation1.45101256
37MP0003763_abnormal_thymus_physiology1.44644647
38MP0003195_calcinosis1.43992740
39MP0004381_abnormal_hair_follicle1.43156032
40MP0002086_abnormal_extraembryonic_tissu1.42615114
41MP0006072_abnormal_retinal_apoptosis1.41360968
42MP0001873_stomach_inflammation1.38706575
43MP0005395_other_phenotype1.38652381
44MP0003984_embryonic_growth_retardation1.38617143
45MP0004264_abnormal_extraembryonic_tissu1.37024187
46MP0002088_abnormal_embryonic_growth/wei1.35056177
47MP0006292_abnormal_olfactory_placode1.33963851
48MP0002876_abnormal_thyroid_physiology1.32979337
49MP0002163_abnormal_gland_morphology1.32139571
50MP0002210_abnormal_sex_determination1.31987210
51MP0002132_abnormal_respiratory_system1.31263352
52MP0001293_anophthalmia1.30768777
53MP0002019_abnormal_tumor_incidence1.30248269
54MP0009379_abnormal_foot_pigmentation1.27324203
55MP0005551_abnormal_eye_electrophysiolog1.27224558
56* MP0002080_prenatal_lethality1.26933743
57MP0003718_maternal_effect1.25816888
58MP0003136_yellow_coat_color1.25426923
59MP0003937_abnormal_limbs/digits/tail_de1.23351195
60MP0002928_abnormal_bile_duct1.20902308
61MP0004142_abnormal_muscle_tone1.19997486
62MP0004197_abnormal_fetal_growth/weight/1.19625536
63MP0000427_abnormal_hair_cycle1.19367773
64MP0001984_abnormal_olfaction1.19331916
65MP0008789_abnormal_olfactory_epithelium1.17530603
66MP0001929_abnormal_gametogenesis1.17016264
67MP0002234_abnormal_pharynx_morphology1.16492425
68MP0001145_abnormal_male_reproductive1.15768843
69MP0000703_abnormal_thymus_morphology1.15343312
70MP0002277_abnormal_respiratory_mucosa1.14882762
71MP0005408_hypopigmentation1.13985972
72MP0005671_abnormal_response_to1.13969925
73MP0000613_abnormal_salivary_gland1.13421316
74MP0002653_abnormal_ependyma_morphology1.10780465
75MP0000313_abnormal_cell_death1.10453810
76MP0004133_heterotaxia1.08727020
77MP0003567_abnormal_fetal_cardiomyocyte1.08237422
78MP0000653_abnormal_sex_gland1.07218498
79MP0002160_abnormal_reproductive_system1.06240718
80MP0002166_altered_tumor_susceptibility1.05408212
81MP0003183_abnormal_peptide_metabolism1.05045948
82MP0000015_abnormal_ear_pigmentation1.04803145
83MP0003698_abnormal_male_reproductive1.04773637
84MP0005389_reproductive_system_phenotype1.02967881
85MP0005174_abnormal_tail_pigmentation1.02803274
86MP0002398_abnormal_bone_marrow1.02110732
87MP0001764_abnormal_homeostasis0.98248469
88MP0003252_abnormal_bile_duct0.97964191
89MP0000678_abnormal_parathyroid_gland0.97280939
90MP0002638_abnormal_pupillary_reflex0.96621487
91MP0005397_hematopoietic_system_phenotyp0.95542026
92MP0001545_abnormal_hematopoietic_system0.95542026
93MP0008872_abnormal_physiological_respon0.95046073
94MP0006036_abnormal_mitochondrial_physio0.94817918
95MP0000383_abnormal_hair_follicle0.94734995
96MP0004043_abnormal_pH_regulation0.93297379
97MP0002006_tumorigenesis0.92959067
98MP0009053_abnormal_anal_canal0.92378359
99MP0001119_abnormal_female_reproductive0.91606609
100MP0002420_abnormal_adaptive_immunity0.91416308
101MP0005084_abnormal_gallbladder_morpholo0.90359090
102MP0003119_abnormal_digestive_system0.90121849
103MP0001188_hyperpigmentation0.90005902
104MP0005645_abnormal_hypothalamus_physiol0.88268533
105MP0005410_abnormal_fertilization0.87986427
106MP0003705_abnormal_hypodermis_morpholog0.87765216
107MP0001819_abnormal_immune_cell0.87560576
108MP0000432_abnormal_head_morphology0.87301598
109MP0002723_abnormal_immune_serum0.87052337
110MP0002722_abnormal_immune_system0.86548183
111MP0000685_abnormal_immune_system0.86186590
112MP0002102_abnormal_ear_morphology0.86118563
113MP0000569_abnormal_digit_pigmentation0.84906374
114MP0003935_abnormal_craniofacial_develop0.83367032
115MP0005379_endocrine/exocrine_gland_phen0.82651359
116MP0000516_abnormal_urinary_system0.82285305
117MP0005367_renal/urinary_system_phenotyp0.82285305
118MP0002452_abnormal_antigen_presenting0.81770479
119MP0005621_abnormal_cell_physiology0.80960494
120MP0003186_abnormal_redox_activity0.80872134
121MP0003941_abnormal_skin_development0.80594221
122MP0005085_abnormal_gallbladder_physiolo0.80371628
123MP0009703_decreased_birth_body0.80291572
124MP0000689_abnormal_spleen_morphology0.80277290
125MP0000428_abnormal_craniofacial_morphol0.79150931
126MP0008995_early_reproductive_senescence0.77921007
127MP0002233_abnormal_nose_morphology0.77893763
128MP0005384_cellular_phenotype0.77826428
129MP0001790_abnormal_immune_system0.77548306
130MP0005387_immune_system_phenotype0.77548306
131MP0003283_abnormal_digestive_organ0.77241759
132MP0005220_abnormal_exocrine_pancreas0.75127070
133MP0010678_abnormal_skin_adnexa0.75025489
134MP0001666_abnormal_nutrient_absorption0.74164479
135MP0002075_abnormal_coat/hair_pigmentati0.73268877
136MP0005253_abnormal_eye_physiology0.73192688
137* MP0003755_abnormal_palate_morphology0.73148160
138MP0010030_abnormal_orbit_morphology0.72653145
139MP0002938_white_spotting0.72109807
140MP0005499_abnormal_olfactory_system0.71225429
141MP0005394_taste/olfaction_phenotype0.71225429
142MP0001186_pigmentation_phenotype0.69914047
143MP0003699_abnormal_female_reproductive0.68846054
144MP0002161_abnormal_fertility/fecundity0.68617280
145MP0002095_abnormal_skin_pigmentation0.67360056
146MP0001286_abnormal_eye_development0.66695938
147MP0001944_abnormal_pancreas_morphology0.66640192
148MP0002098_abnormal_vibrissa_morphology0.66044808
149MP0000716_abnormal_immune_system0.65805829
150* MP0002925_abnormal_cardiovascular_devel0.65248608
151MP0001800_abnormal_humoral_immune0.63910147
152MP0002429_abnormal_blood_cell0.63645304
153MP0001986_abnormal_taste_sensitivity0.62038238
154MP0002693_abnormal_pancreas_physiology0.60977608
155MP0005310_abnormal_salivary_gland0.60646791
156MP0003566_abnormal_cell_adhesion0.60074436
157MP0003315_abnormal_perineum_morphology0.60019949

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.59458302
2Birth length less than 3rd percentile (HP:0003561)4.49089444
3Pancreatic fibrosis (HP:0100732)4.19253201
4Chromsome breakage (HP:0040012)3.87593064
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40614452
6Oligodactyly (hands) (HP:0001180)3.28183754
7Colon cancer (HP:0003003)3.06415118
8Prominent nose (HP:0000448)3.05499400
9Chronic hepatic failure (HP:0100626)3.03757542
10Abnormality of the fingertips (HP:0001211)2.99001248
11Dynein arm defect of respiratory motile cilia (HP:0012255)2.98404789
12Absent/shortened dynein arms (HP:0200106)2.98404789
13Abnormality of chromosome stability (HP:0003220)2.95305499
14Myelodysplasia (HP:0002863)2.95251223
15* Pancreatic cysts (HP:0001737)2.93707755
16Medial flaring of the eyebrow (HP:0010747)2.88066272
17* Median cleft lip (HP:0000161)2.78168251
18Patellar aplasia (HP:0006443)2.74139565
193-Methylglutaconic aciduria (HP:0003535)2.72034607
20True hermaphroditism (HP:0010459)2.68471019
21Abnormal ciliary motility (HP:0012262)2.68464004
22* Abnormality of midbrain morphology (HP:0002418)2.66717964
23* Molar tooth sign on MRI (HP:0002419)2.66717964
24Truncal obesity (HP:0001956)2.66477593
25Abnormal biliary tract physiology (HP:0012439)2.65965595
26Bile duct proliferation (HP:0001408)2.65965595
27Medulloblastoma (HP:0002885)2.64985051
28Ependymoma (HP:0002888)2.64069675
29* Facial hemangioma (HP:0000329)2.62252808
30Rhabdomyosarcoma (HP:0002859)2.61126220
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.59478162
32Acute myeloid leukemia (HP:0004808)2.57283578
33Shawl scrotum (HP:0000049)2.54468129
34Amaurosis fugax (HP:0100576)2.52865077
35Abnormality of the labia minora (HP:0012880)2.52313308
36Congenital primary aphakia (HP:0007707)2.50577560
37Aplasia/Hypoplasia of the patella (HP:0006498)2.50312571
38Nephronophthisis (HP:0000090)2.49326580
39Abnormal respiratory motile cilium physiology (HP:0012261)2.47080084
40Long clavicles (HP:0000890)2.41337227
41Abnormality of the renal cortex (HP:0011035)2.38938750
42Abnormality of the preputium (HP:0100587)2.37249391
43Thrombocytosis (HP:0001894)2.36935575
44Spinal muscular atrophy (HP:0007269)2.35873550
45Abnormal respiratory motile cilium morphology (HP:0005938)2.35329455
46Abnormal respiratory epithelium morphology (HP:0012253)2.35329455
47Hypochromic microcytic anemia (HP:0004840)2.35326425
48Gait imbalance (HP:0002141)2.34507614
49Breast hypoplasia (HP:0003187)2.34468720
50Rib fusion (HP:0000902)2.34435820
51Ectopic kidney (HP:0000086)2.34269425
52* Neoplasm of the oral cavity (HP:0100649)2.34108915
53Nephrogenic diabetes insipidus (HP:0009806)2.31932198
54Increased nuchal translucency (HP:0010880)2.30247281
55Postaxial foot polydactyly (HP:0001830)2.28957215
56Abnormality of the renal medulla (HP:0100957)2.28761243
57* Lip pit (HP:0100267)2.25866601
58Meckel diverticulum (HP:0002245)2.25468686
59Abnormality of the ileum (HP:0001549)2.24033613
60Nephroblastoma (Wilms tumor) (HP:0002667)2.22212150
61Genital tract atresia (HP:0001827)2.22151189
62Basal cell carcinoma (HP:0002671)2.21540685
63* Capillary hemangiomas (HP:0005306)2.18945722
64Biliary tract neoplasm (HP:0100574)2.18607022
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.18162654
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.17974157
67Degeneration of anterior horn cells (HP:0002398)2.17922152
68Abnormality of the anterior horn cell (HP:0006802)2.17922152
6911 pairs of ribs (HP:0000878)2.17374485
70Severe combined immunodeficiency (HP:0004430)2.15490052
71Poor coordination (HP:0002370)2.13659037
72Selective tooth agenesis (HP:0001592)2.12350674
73Papillary thyroid carcinoma (HP:0002895)2.12040589
74Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.09392182
75Missing ribs (HP:0000921)2.09333773
76Aplasia/Hypoplasia of the sternum (HP:0006714)2.08044510
77Renal cortical cysts (HP:0000803)2.07032940
78Impulsivity (HP:0100710)2.06290729
79Bronchiectasis (HP:0002110)2.05925471
80Cafe-au-lait spot (HP:0000957)2.05471788
81Oligodactyly (HP:0012165)2.05062201
82Sandal gap (HP:0001852)2.04836010
83Sloping forehead (HP:0000340)2.03240361
84Microtia (HP:0008551)2.02160706
85Small intestinal stenosis (HP:0012848)2.00817027
86Duodenal stenosis (HP:0100867)2.00817027
87Vaginal atresia (HP:0000148)2.00646305
88Type II lissencephaly (HP:0007260)1.99984666
89Abnormality of the astrocytes (HP:0100707)1.98201620
90Astrocytoma (HP:0009592)1.98201620
91Embryonal renal neoplasm (HP:0011794)1.97372373
92Glioma (HP:0009733)1.95615922
93Absent radius (HP:0003974)1.95501572
94Intestinal atresia (HP:0011100)1.95181671
95Acute necrotizing encephalopathy (HP:0006965)1.94962420
96Facial cleft (HP:0002006)1.93296600
97Thyroiditis (HP:0100646)1.93275499
98Long eyelashes (HP:0000527)1.92004955
99Hypoplastic labia majora (HP:0000059)1.91753201
100Deviation of the thumb (HP:0009603)1.90885381
101Congenital hepatic fibrosis (HP:0002612)1.90802080
102Abnormality of DNA repair (HP:0003254)1.90488028
103Short tibia (HP:0005736)1.90273985
104Chronic sinusitis (HP:0011109)1.89758840
105Proximal placement of thumb (HP:0009623)1.88841585
106Rhinitis (HP:0012384)1.88457484
107IgG deficiency (HP:0004315)1.88222572
108Tubulointerstitial nephritis (HP:0001970)1.87567700
109Supernumerary spleens (HP:0009799)1.86447033
110Agnosia (HP:0010524)1.85051855
111Thoracolumbar scoliosis (HP:0002944)1.84997910
112Recurrent bronchitis (HP:0002837)1.84929312
113Abnormality of the prostate (HP:0008775)1.84756910
114Reticulocytopenia (HP:0001896)1.84713098
115Male pseudohermaphroditism (HP:0000037)1.83864876
116Acute encephalopathy (HP:0006846)1.83531474
117Hypoplastic iliac wings (HP:0002866)1.83524007
118Triphalangeal thumb (HP:0001199)1.83276142
119Panhypogammaglobulinemia (HP:0003139)1.82474593
120High pitched voice (HP:0001620)1.82387722
121Optic nerve coloboma (HP:0000588)1.82323260
122* Cystic liver disease (HP:0006706)1.81341323
123* Preaxial hand polydactyly (HP:0001177)1.81328821
124Mitochondrial inheritance (HP:0001427)1.81011001
125Neoplasm of striated muscle (HP:0009728)1.80994521
126Dyschromatopsia (HP:0007641)1.80475919
127Sparse lateral eyebrow (HP:0005338)1.80352704
128Increased CSF lactate (HP:0002490)1.79681069
129Abnormal pancreas size (HP:0012094)1.78536250
130Atresia of the external auditory canal (HP:0000413)1.78185687
131Abnormality of the carotid arteries (HP:0005344)1.77617242
132Progressive macrocephaly (HP:0004481)1.77259151
133Aplasia involving forearm bones (HP:0009822)1.77198258
134Absent forearm bone (HP:0003953)1.77198258
135Clubbing of toes (HP:0100760)1.75385262
136Malignant gastrointestinal tract tumors (HP:0006749)1.75375971
137Gastrointestinal carcinoma (HP:0002672)1.75375971
138Neoplasm of the pancreas (HP:0002894)1.74777820
139Combined immunodeficiency (HP:0005387)1.73838580
140Bronchitis (HP:0012387)1.73798395
141Abnormality of the labia majora (HP:0012881)1.73361155
142Cleft eyelid (HP:0000625)1.73049339
143Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.72671515
144Short 1st metacarpal (HP:0010034)1.72671515
145Infertility (HP:0000789)1.72486389
146Aplasia/hypoplasia of the humerus (HP:0006507)1.72301395
147Absent thumb (HP:0009777)1.71886685
148Bone marrow hypocellularity (HP:0005528)1.71574122
149Abnormality of the renal collecting system (HP:0004742)1.71088072
150Agammaglobulinemia (HP:0004432)1.70783821
151Abnormality of the duodenum (HP:0002246)1.70742488
152Abnormal biliary tract morphology (HP:0012440)1.70294221
153* Postaxial hand polydactyly (HP:0001162)1.69630752
154Squamous cell carcinoma (HP:0002860)1.69371199
155Neoplasm of the colon (HP:0100273)1.68686188
156Asplenia (HP:0001746)1.68526955
157Macrocytic anemia (HP:0001972)1.68292311
158Poikiloderma (HP:0001029)1.67098467
159Anencephaly (HP:0002323)1.67008118
160Abnormality of the hepatic vasculature (HP:0006707)1.66913203
161Metaphyseal dysplasia (HP:0100255)1.66793221
162Neoplasm of the tracheobronchial system (HP:0100552)1.66781667
163Aplasia/Hypoplasia of the earlobes (HP:0009906)1.66311437
164Abnormal hair whorl (HP:0010721)1.66117215
165Alveolar cell carcinoma (HP:0006519)1.65859207
166Entropion (HP:0000621)1.65841001
167Attenuation of retinal blood vessels (HP:0007843)1.65712275
168Stenosis of the external auditory canal (HP:0000402)1.65631583
169Gonadotropin excess (HP:0000837)1.64581296
170Papilledema (HP:0001085)1.64250506
171Short humerus (HP:0005792)1.64039791
172Short thumb (HP:0009778)1.63564652
173Abnormal mitochondria in muscle tissue (HP:0008316)1.63056969
174Pustule (HP:0200039)1.61822791
175Abnormal delayed hypersensitivity skin test (HP:0002963)1.61743420
176Severe visual impairment (HP:0001141)1.61633842
177Astigmatism (HP:0000483)1.60485510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.49825633
2CDK124.34334838
3MST43.32203992
4FRK2.96684394
5WEE12.83643890
6TXK2.72923129
7TNIK2.64100868
8NEK22.55616132
9TTK2.43572394
10LATS12.30814058
11BRSK22.27008964
12BRD42.24482292
13PASK2.21278907
14EPHA22.15091326
15PLK12.09074386
16CDK191.98714974
17CHEK21.95078543
18PLK41.91869164
19STK391.84809809
20OXSR11.82095724
21STK101.73160967
22SRPK11.69005383
23CDK71.68926587
24MAP3K61.66777202
25TAOK31.63535031
26NME21.63048739
27ATR1.61830190
28STK31.61705815
29MELK1.60789265
30ACVR1B1.55401186
31BUB11.54306058
32WNK41.53997288
33AURKB1.52768779
34SCYL21.51851376
35PDK21.49607733
36PIK3CG1.49117821
37FLT31.47817933
38CHEK11.45679891
39GRK11.42194115
40JAK31.42172585
41MAP4K21.39575424
42TRIM281.38712276
43RPS6KB21.38163141
44PLK31.37006462
45ZAK1.35713684
46TNK21.35279756
47NLK1.26418233
48CDK61.26095463
49ATM1.25553201
50MKNK21.23457789
51HIPK21.22608542
52EEF2K1.19795989
53CDK41.18201492
54STK38L1.17821011
55MAP3K121.15103817
56NEK61.08430033
57PNCK1.07618990
58DYRK31.05674912
59BTK1.05095131
60MAPK131.04282410
61CDK21.03657179
62ITK1.03108348
63VRK11.01798225
64CDK91.01724815
65TGFBR11.00702725
66STK40.98938506
67CDK80.97295316
68MUSK0.96146339
69MKNK10.94376639
70PIM10.92964300
71IKBKE0.91791259
72BRSK10.90742745
73RPS6KA40.90500980
74PRKCQ0.90357287
75MAP3K40.88810032
76LATS20.88028142
77NME10.83902497
78BRAF0.82968995
79BCR0.80372887
80STK160.79746186
81IKBKB0.78609402
82CDK10.77427103
83MAP3K80.75980175
84EIF2AK30.75808596
85AURKA0.74834965
86PIK3CA0.72223265
87EIF2AK10.71463031
88TRPM70.71157216
89ALK0.70897200
90MAPK150.70712743
91MTOR0.70256940
92GRK60.69926463
93SYK0.69566965
94CASK0.69545823
95AKT30.68749649
96NUAK10.68671641
97PRKCI0.67582992
98SGK20.66338894
99MAP3K130.64552310
100RAF10.63786036
101PRKD30.63105787
102MOS0.62814400
103RIPK10.62638537
104RPS6KB10.61781223
105TSSK60.61027036
106MAPK140.60114841
107CSNK1D0.59943361
108PRKD20.59394692
109CSF1R0.58854178
110PAK30.58805121
111YES10.57236012
112CHUK0.57065084
113LYN0.56850825
114PRKDC0.55534086
115IRAK40.53989856
116MAP3K100.53493602
117LRRK20.52679829
118BMPR1B0.51236523
119MAPKAPK30.51115529
120TLK10.50945862
121CSNK2A20.50388516
122BMPR20.50094815
123TEC0.49937800
124MAP3K30.49504926
125STK240.49314908
126LCK0.48954462
127MAPK100.48560380
128CSNK1E0.48093880
129EIF2AK20.47348360
130RPS6KA50.47238849
131WNK30.46802462
132MAPK10.46492415
133MAP4K10.45750709
134BCKDK0.45205188
135AKT10.44680626
136TAOK10.44629240
137ADRBK20.42931645
138GSK3B0.41755955
139ERBB40.40517931
140CDC42BPA0.40415021
141TYK20.39858806
142IRAK10.39756366
143MAP2K30.39483917
144CDK30.39267475
145WNK10.38921938
146DMPK0.38620327
147RIPK40.36005186
148CSNK1G10.35391388
149CSNK2A10.34664538
150MAPK110.34480796
151MARK30.34369922
152DYRK1B0.34159254
153INSRR0.32483365

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.99066750
2DNA replication_Homo sapiens_hsa030303.87631783
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09521378
4Cell cycle_Homo sapiens_hsa041102.85604574
5Homologous recombination_Homo sapiens_hsa034402.82384681
6RNA transport_Homo sapiens_hsa030132.80979090
7Nucleotide excision repair_Homo sapiens_hsa034202.49372353
8Non-homologous end-joining_Homo sapiens_hsa034502.48780312
9Base excision repair_Homo sapiens_hsa034102.45010672
10Spliceosome_Homo sapiens_hsa030402.41346621
11RNA polymerase_Homo sapiens_hsa030202.37657630
12Fanconi anemia pathway_Homo sapiens_hsa034602.35589877
13RNA degradation_Homo sapiens_hsa030182.29700803
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24550122
15mRNA surveillance pathway_Homo sapiens_hsa030152.04833107
16Basal transcription factors_Homo sapiens_hsa030222.03685972
17p53 signaling pathway_Homo sapiens_hsa041151.93275167
18One carbon pool by folate_Homo sapiens_hsa006701.89726318
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.88935012
20Autoimmune thyroid disease_Homo sapiens_hsa053201.86055522
21Graft-versus-host disease_Homo sapiens_hsa053321.80918257
22Allograft rejection_Homo sapiens_hsa053301.80859051
23Regulation of autophagy_Homo sapiens_hsa041401.74531306
24Caffeine metabolism_Homo sapiens_hsa002321.61667764
25Asthma_Homo sapiens_hsa053101.59207349
26Pyrimidine metabolism_Homo sapiens_hsa002401.53538434
27Oxidative phosphorylation_Homo sapiens_hsa001901.53441024
28Phototransduction_Homo sapiens_hsa047441.52121627
29Linoleic acid metabolism_Homo sapiens_hsa005911.51839400
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49030025
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45866123
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.42173787
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41295830
34Nitrogen metabolism_Homo sapiens_hsa009101.39018520
35Propanoate metabolism_Homo sapiens_hsa006401.36715244
36Ribosome_Homo sapiens_hsa030101.32614832
37Proteasome_Homo sapiens_hsa030501.26806689
38MicroRNAs in cancer_Homo sapiens_hsa052061.23230436
39Chemical carcinogenesis_Homo sapiens_hsa052041.22672247
40Antigen processing and presentation_Homo sapiens_hsa046121.22646467
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22570778
42Herpes simplex infection_Homo sapiens_hsa051681.22430238
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21836909
44Viral carcinogenesis_Homo sapiens_hsa052031.21292876
45Huntingtons disease_Homo sapiens_hsa050161.19283096
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18866571
47Parkinsons disease_Homo sapiens_hsa050121.16861123
48Epstein-Barr virus infection_Homo sapiens_hsa051691.16433827
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14665266
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14265800
51TGF-beta signaling pathway_Homo sapiens_hsa043501.13620730
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10781569
53Systemic lupus erythematosus_Homo sapiens_hsa053221.09370493
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06922298
55Circadian rhythm_Homo sapiens_hsa047101.06051484
56HTLV-I infection_Homo sapiens_hsa051661.05121422
57Olfactory transduction_Homo sapiens_hsa047401.04729518
58Thyroid cancer_Homo sapiens_hsa052161.03410521
59Protein export_Homo sapiens_hsa030601.01711613
60Pancreatic cancer_Homo sapiens_hsa052120.99226541
61Colorectal cancer_Homo sapiens_hsa052100.98528258
62Oocyte meiosis_Homo sapiens_hsa041140.98278729
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98210511
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95919544
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.95140409
66Primary immunodeficiency_Homo sapiens_hsa053400.92096192
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.91208981
68Butanoate metabolism_Homo sapiens_hsa006500.88697477
69Adherens junction_Homo sapiens_hsa045200.87501298
70Small cell lung cancer_Homo sapiens_hsa052220.87209342
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.86064140
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85906082
73Lysine degradation_Homo sapiens_hsa003100.84474756
74mTOR signaling pathway_Homo sapiens_hsa041500.83999820
75Chronic myeloid leukemia_Homo sapiens_hsa052200.83209892
76Purine metabolism_Homo sapiens_hsa002300.82171005
77Hippo signaling pathway_Homo sapiens_hsa043900.81203412
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81046223
79Vitamin digestion and absorption_Homo sapiens_hsa049770.80744257
80Ether lipid metabolism_Homo sapiens_hsa005650.79261811
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77483188
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75802355
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73333954
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.71055787
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70277185
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69858620
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69399497
88Prostate cancer_Homo sapiens_hsa052150.68002206
89Hepatitis B_Homo sapiens_hsa051610.67821090
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67730812
91Measles_Homo sapiens_hsa051620.66689036
92Retinol metabolism_Homo sapiens_hsa008300.66608146
93FoxO signaling pathway_Homo sapiens_hsa040680.66311999
94Arachidonic acid metabolism_Homo sapiens_hsa005900.66057047
95Notch signaling pathway_Homo sapiens_hsa043300.63962794
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62353469
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.61628070
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61428030
99ABC transporters_Homo sapiens_hsa020100.60540783
100Wnt signaling pathway_Homo sapiens_hsa043100.58446747
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57898315
102Pathways in cancer_Homo sapiens_hsa052000.57210805
103Non-small cell lung cancer_Homo sapiens_hsa052230.57105467
104Peroxisome_Homo sapiens_hsa041460.56751055
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55852357
106Prolactin signaling pathway_Homo sapiens_hsa049170.55648865
107Alcoholism_Homo sapiens_hsa050340.54533847
108B cell receptor signaling pathway_Homo sapiens_hsa046620.53777758
109Acute myeloid leukemia_Homo sapiens_hsa052210.52784696
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.52175643
111Apoptosis_Homo sapiens_hsa042100.51585089
112N-Glycan biosynthesis_Homo sapiens_hsa005100.50784219
113Inositol phosphate metabolism_Homo sapiens_hsa005620.50395091
114Ovarian steroidogenesis_Homo sapiens_hsa049130.49130916
115Influenza A_Homo sapiens_hsa051640.47890851
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43779006
117Bladder cancer_Homo sapiens_hsa052190.43245195
118Glutathione metabolism_Homo sapiens_hsa004800.43178423
119Hematopoietic cell lineage_Homo sapiens_hsa046400.41953623
120T cell receptor signaling pathway_Homo sapiens_hsa046600.41127510
121Hedgehog signaling pathway_Homo sapiens_hsa043400.40751336
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40079395
123Basal cell carcinoma_Homo sapiens_hsa052170.39001198
124Alzheimers disease_Homo sapiens_hsa050100.38648351
125Endometrial cancer_Homo sapiens_hsa052130.38044547
126Type I diabetes mellitus_Homo sapiens_hsa049400.37803321
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37452786
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.37370086
129Viral myocarditis_Homo sapiens_hsa054160.37262644
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.36258080
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35891354
132Selenocompound metabolism_Homo sapiens_hsa004500.35340800
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35155131
134Melanoma_Homo sapiens_hsa052180.34979200
135Dorso-ventral axis formation_Homo sapiens_hsa043200.34974389
136Toxoplasmosis_Homo sapiens_hsa051450.34384306
137Metabolic pathways_Homo sapiens_hsa011000.34288145
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34245942
139Fat digestion and absorption_Homo sapiens_hsa049750.33784490
140Renal cell carcinoma_Homo sapiens_hsa052110.33315872
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33313659
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32673166
143Osteoclast differentiation_Homo sapiens_hsa043800.32652409
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32647865
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31807751
146Choline metabolism in cancer_Homo sapiens_hsa052310.31332204
147Taste transduction_Homo sapiens_hsa047420.30961924
148Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30297764
149Proteoglycans in cancer_Homo sapiens_hsa052050.30102145
150Fatty acid elongation_Homo sapiens_hsa000620.29875258
151Shigellosis_Homo sapiens_hsa051310.29236742
152Leishmaniasis_Homo sapiens_hsa051400.27706856
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26734361
154Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26218929

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