OFD1P6Y

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of synaptic transmission, dopaminergic (GO:0032226)9.16761981
2regulation of phosphoprotein phosphatase activity (GO:0043666)8.92895310
3positive regulation of catecholamine secretion (GO:0033605)8.90912232
4male meiosis (GO:0007140)8.37604047
5acrosome reaction (GO:0007340)7.52365225
6spermatid development (GO:0007286)7.33316929
7sperm motility (GO:0030317)6.77796476
8regulation of oxidative stress-induced neuron death (GO:1903203)6.34171704
9binding of sperm to zona pellucida (GO:0007339)6.30319757
10multicellular organism reproduction (GO:0032504)6.10967931
11potassium ion export (GO:0071435)6.10424599
12motile cilium assembly (GO:0044458)5.96409683
13cilium or flagellum-dependent cell motility (GO:0001539)5.47614253
14axonemal dynein complex assembly (GO:0070286)5.43091924
15epithelial cilium movement (GO:0003351)5.34757990
16polyamine biosynthetic process (GO:0006596)5.32536717
17relaxation of smooth muscle (GO:0044557)5.31282446
18sperm-egg recognition (GO:0035036)5.25649433
19protein-DNA complex disassembly (GO:0032986)5.21678396
20nucleosome disassembly (GO:0006337)5.21678396
21synapsis (GO:0007129)5.19311900
22cGMP-mediated signaling (GO:0019934)5.16362472
23regulation of oxidative phosphorylation (GO:0002082)5.08966430
24cell-cell recognition (GO:0009988)4.81524131
25organic cation transport (GO:0015695)4.81412643
26Leydig cell differentiation (GO:0033327)4.79479187
27activation of protein kinase B activity (GO:0032148)4.77683707
28glutamine family amino acid catabolic process (GO:0009065)4.58051940
29regulation of dopamine secretion (GO:0014059)4.56789652
30regulation of synaptic transmission, dopaminergic (GO:0032225)4.50157321
31histone H2A acetylation (GO:0043968)4.46154925
32cilium movement (GO:0003341)4.34733532
33androgen biosynthetic process (GO:0006702)4.26707357
34male sex determination (GO:0030238)4.26022472
35mitochondrion degradation (GO:0000422)4.24121446
36protein polymerization (GO:0051258)4.21257191
37germ cell development (GO:0007281)4.20017024
38negative regulation of hydrogen peroxide-induced cell death (GO:1903206)4.15344221
39single fertilization (GO:0007338)4.12894325
40regulation of cellular respiration (GO:0043457)4.09717081
41reproduction (GO:0000003)4.09514241
42TOR signaling (GO:0031929)4.08552540
43positive regulation of glycolytic process (GO:0045821)4.01228576
44regulation of autophagic vacuole assembly (GO:2000785)3.95613336
45ventricular system development (GO:0021591)3.94807369
46cellular biogenic amine biosynthetic process (GO:0042401)3.89150411
47acrosome assembly (GO:0001675)3.88943941
48amine biosynthetic process (GO:0009309)3.85445145
49regulation of hydrogen peroxide-induced cell death (GO:1903205)3.83459243
50tongue development (GO:0043586)3.82319028
51positive regulation of amine transport (GO:0051954)3.81532917
52negative regulation of response to reactive oxygen species (GO:1901032)3.79512406
53coenzyme catabolic process (GO:0009109)3.78337561
54glycogen metabolic process (GO:0005977)3.70501601
55histone exchange (GO:0043486)3.69215080
56tryptophan catabolic process (GO:0006569)3.67023714
57indole-containing compound catabolic process (GO:0042436)3.67023714
58indolalkylamine catabolic process (GO:0046218)3.67023714
59glucan metabolic process (GO:0044042)3.66590945
60cellular glucan metabolic process (GO:0006073)3.66590945
61aspartate family amino acid catabolic process (GO:0009068)3.66292956
62dicarboxylic acid biosynthetic process (GO:0043650)3.65678958
63polyamine metabolic process (GO:0006595)3.64769563
64membrane repolarization (GO:0086009)3.59576834
65DNA double-strand break processing (GO:0000729)3.53720529
66oogenesis (GO:0048477)3.46908231
67diacylglycerol metabolic process (GO:0046339)3.46520523
68epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.44575889
69detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.39365956
70chromosome organization involved in meiosis (GO:0070192)3.38664651
71regulation of vacuole organization (GO:0044088)3.37820042
72behavioral response to nicotine (GO:0035095)3.35822644
73negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.34540449
74membrane repolarization during action potential (GO:0086011)3.30067892
75oligosaccharide biosynthetic process (GO:0009312)3.27663386
76regulation of phosphatase activity (GO:0010921)3.21291261
77cellular process involved in reproduction in multicellular organism (GO:0022412)3.16053322
78response to acidic pH (GO:0010447)3.13000806
79calcium ion-dependent exocytosis (GO:0017156)3.11178063
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.08950217
81fusion of sperm to egg plasma membrane (GO:0007342)3.07117998
82dicarboxylic acid catabolic process (GO:0043649)3.03576041
83meiotic nuclear division (GO:0007126)3.02785741
84response to mercury ion (GO:0046689)3.01439402
85piRNA metabolic process (GO:0034587)2.99526559
86energy homeostasis (GO:0097009)2.97389367
87negative regulation of JNK cascade (GO:0046329)2.96298256
88intraciliary transport (GO:0042073)2.93773055
89L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88129898
90mitochondrion morphogenesis (GO:0070584)2.86906187
91phosphate ion transport (GO:0006817)2.86473957
92fertilization (GO:0009566)2.85751892
93negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83333930
94tryptophan metabolic process (GO:0006568)2.80354487
95DNA methylation involved in gamete generation (GO:0043046)2.80158534
96cilium morphogenesis (GO:0060271)2.78278493
97regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.78122756
98indole-containing compound metabolic process (GO:0042430)2.77628135
99negative regulation of smooth muscle contraction (GO:0045986)2.73673638
100methionine biosynthetic process (GO:0009086)2.73301903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.15537022
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.38904335
3IGF1R_20145208_ChIP-Seq_DFB_Human5.16420162
4GATA1_22025678_ChIP-Seq_K562_Human5.00456222
5EZH2_22144423_ChIP-Seq_EOC_Human4.30638346
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.24990182
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.19458248
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.83284904
9GBX2_23144817_ChIP-Seq_PC3_Human2.77352866
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.47699583
11FUS_26573619_Chip-Seq_HEK293_Human2.40459623
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.35232695
13ZNF274_21170338_ChIP-Seq_K562_Hela2.31583904
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29701739
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26447390
16VDR_22108803_ChIP-Seq_LS180_Human2.24530143
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12996139
18AR_21572438_ChIP-Seq_LNCaP_Human2.04458892
19ER_23166858_ChIP-Seq_MCF-7_Human1.99506378
20AHR_22903824_ChIP-Seq_MCF-7_Human1.77375388
21TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75384882
22POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.75384882
23UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72724489
24SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.71329990
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71313005
26BCAT_22108803_ChIP-Seq_LS180_Human1.68789340
27KLF5_20875108_ChIP-Seq_MESCs_Mouse1.67759631
28P300_19829295_ChIP-Seq_ESCs_Human1.64436231
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.64292392
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59038206
31CBP_20019798_ChIP-Seq_JUKART_Human1.59038206
32WDR5_24793694_ChIP-Seq_LNCAP_Human1.51970235
33RUNX2_22187159_ChIP-Seq_PCA_Human1.49419755
34TP53_18474530_ChIP-ChIP_U2OS_Human1.48137408
35SMAD4_21799915_ChIP-Seq_A2780_Human1.44074016
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.43969524
37ZNF263_19887448_ChIP-Seq_K562_Human1.40750907
38OCT4_20526341_ChIP-Seq_ESCs_Human1.35668698
39RXR_22108803_ChIP-Seq_LS180_Human1.34841766
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33110886
41STAT3_23295773_ChIP-Seq_U87_Human1.32120177
42NANOG_20526341_ChIP-Seq_ESCs_Human1.30073935
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29384772
44AR_25329375_ChIP-Seq_VCAP_Human1.27689536
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27667277
46ERA_21632823_ChIP-Seq_H3396_Human1.26943779
47AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26688260
48OCT1_27270436_Chip-Seq_PROSTATE_Human1.26661912
49SOX2_19829295_ChIP-Seq_ESCs_Human1.26134825
50NANOG_19829295_ChIP-Seq_ESCs_Human1.26134825
51PRDM14_20953172_ChIP-Seq_ESCs_Human1.24774367
52SMAD4_21741376_ChIP-Seq_EPCs_Human1.21660206
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21122352
54RAC3_21632823_ChIP-Seq_H3396_Human1.19019851
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18887979
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18341213
57CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14502966
58P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14463543
59MYC_19829295_ChIP-Seq_ESCs_Human1.11518279
60PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10013983
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09467977
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08704331
63TBL1_22424771_ChIP-Seq_293T_Human1.07312819
64SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06525915
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05276535
66ERG_20517297_ChIP-Seq_VCAP_Human1.04560189
67MYC_18940864_ChIP-ChIP_HL60_Human1.03099485
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01564424
69TCF4_22108803_ChIP-Seq_LS180_Human1.00510984
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00098641
71EWS_26573619_Chip-Seq_HEK293_Human0.99974389
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99007430
73EED_16625203_ChIP-ChIP_MESCs_Mouse0.98043976
74HOXB7_26014856_ChIP-Seq_BT474_Human0.97693633
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97207804
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94921214
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94093104
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92982656
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91764828
80GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91641433
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91138877
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90428167
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86537979
84NCOR_22424771_ChIP-Seq_293T_Human0.86519800
85SPI1_20517297_ChIP-Seq_HL60_Human0.85591204
86SOX2_21211035_ChIP-Seq_LN229_Gbm0.85373593
87IRF1_19129219_ChIP-ChIP_H3396_Human0.84752310
88RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83589216
89REST_18959480_ChIP-ChIP_MESCs_Mouse0.83326169
90CDX2_22108803_ChIP-Seq_LS180_Human0.83159138
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82896818
92CTCF_27219007_Chip-Seq_Bcells_Human0.82470942
93TCF4_23295773_ChIP-Seq_U87_Human0.82108309
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.81777305
95STAT1_17558387_ChIP-Seq_HELA_Human0.80084041
96FOXH1_21741376_ChIP-Seq_ESCs_Human0.79777589
97E2F1_17053090_ChIP-ChIP_MCF-7_Human0.79247027
98ESET_19884257_ChIP-Seq_ESCs_Mouse0.79009313
99IRF8_21731497_ChIP-ChIP_J774_Mouse0.78261371
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77606075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.03430859
2MP0003315_abnormal_perineum_morphology6.23051915
3MP0008004_abnormal_stomach_pH5.51665696
4MP0003136_yellow_coat_color3.58523034
5MP0002160_abnormal_reproductive_system3.48891941
6MP0001984_abnormal_olfaction3.07789611
7MP0005360_urolithiasis2.63227975
8MP0003698_abnormal_male_reproductive2.57086210
9MP0003045_fibrosis2.54953708
10MP0000537_abnormal_urethra_morphology2.50006265
11MP0005499_abnormal_olfactory_system2.32547391
12MP0005394_taste/olfaction_phenotype2.32547391
13MP0001929_abnormal_gametogenesis2.28806902
14MP0006072_abnormal_retinal_apoptosis2.12641318
15MP0010386_abnormal_urinary_bladder2.05793241
16MP0005647_abnormal_sex_gland2.05617569
17MP0001664_abnormal_digestion1.93113332
18MP0010368_abnormal_lymphatic_system1.84257518
19MP0005389_reproductive_system_phenotype1.82022354
20MP0005187_abnormal_penis_morphology1.80493238
21MP0008995_early_reproductive_senescence1.80238691
22MP0000538_abnormal_urinary_bladder1.80137344
23MP0001501_abnormal_sleep_pattern1.69046530
24MP0000465_gastrointestinal_hemorrhage1.65735695
25MP0005058_abnormal_lysosome_morphology1.61009988
26MP0005248_abnormal_Harderian_gland1.55737420
27MP0008789_abnormal_olfactory_epithelium1.51764554
28MP0003878_abnormal_ear_physiology1.44610722
29MP0005377_hearing/vestibular/ear_phenot1.44610722
30MP0004272_abnormal_basement_membrane1.43897703
31MP0005253_abnormal_eye_physiology1.41088075
32MP0001485_abnormal_pinna_reflex1.40247560
33MP0000631_abnormal_neuroendocrine_gland1.38132279
34MP0002161_abnormal_fertility/fecundity1.33367665
35MP0005646_abnormal_pituitary_gland1.33229913
36MP0001849_ear_inflammation1.28340432
37MP0005551_abnormal_eye_electrophysiolog1.28155375
38MP0002210_abnormal_sex_determination1.27212260
39MP0001486_abnormal_startle_reflex1.23974535
40MP0001145_abnormal_male_reproductive1.23047378
41MP0001529_abnormal_vocalization1.18655701
42MP0006036_abnormal_mitochondrial_physio1.18206354
43MP0001905_abnormal_dopamine_level1.16006862
44MP0005645_abnormal_hypothalamus_physiol1.12820738
45MP0005174_abnormal_tail_pigmentation1.12069911
46MP0004085_abnormal_heartbeat1.11860457
47MP0000569_abnormal_digit_pigmentation1.10458785
48MP0005171_absent_coat_pigmentation1.10417750
49MP0000049_abnormal_middle_ear1.09372320
50MP0000653_abnormal_sex_gland1.08706776
51MP0006276_abnormal_autonomic_nervous1.08280076
52MP0001919_abnormal_reproductive_system1.03436718
53MP0002132_abnormal_respiratory_system1.01423060
54MP0009046_muscle_twitch1.00113716
55MP0002168_other_aberrant_phenotype0.93421363
56MP0002638_abnormal_pupillary_reflex0.92522159
57MP0002102_abnormal_ear_morphology0.90707179
58MP0003718_maternal_effect0.90563291
59MP0006035_abnormal_mitochondrial_morpho0.90495002
60MP0004019_abnormal_vitamin_homeostasis0.90097407
61MP0005395_other_phenotype0.89693518
62MP0002233_abnormal_nose_morphology0.89360346
63MP0003635_abnormal_synaptic_transmissio0.88400701
64MP0002090_abnormal_vision0.84909777
65MP0001963_abnormal_hearing_physiology0.80995671
66MP0002735_abnormal_chemical_nociception0.80926655
67MP0005397_hematopoietic_system_phenotyp0.80879424
68MP0001545_abnormal_hematopoietic_system0.80879424
69MP0002837_dystrophic_cardiac_calcinosis0.80258243
70MP0004133_heterotaxia0.79973753
71MP0004084_abnormal_cardiac_muscle0.79296628
72MP0002272_abnormal_nervous_system0.74932495
73MP0001764_abnormal_homeostasis0.74899237
74MP0003632_abnormal_nervous_system0.74706564
75MP0000026_abnormal_inner_ear0.73586408
76MP0001986_abnormal_taste_sensitivity0.71911090
77MP0002752_abnormal_somatic_nervous0.71900593
78MP0001188_hyperpigmentation0.71490130
79MP0002249_abnormal_larynx_morphology0.70419551
80MP0001756_abnormal_urination0.69829008
81MP0004215_abnormal_myocardial_fiber0.69684211
82MP0000230_abnormal_systemic_arterial0.68317556
83MP0003631_nervous_system_phenotype0.67719684
84MP0005391_vision/eye_phenotype0.67540424
85MP0003936_abnormal_reproductive_system0.65566718
86MP0000470_abnormal_stomach_morphology0.64825030
87MP0002572_abnormal_emotion/affect_behav0.64581637
88MP0009745_abnormal_behavioral_response0.63831616
89MP0003633_abnormal_nervous_system0.63510664
90MP0002557_abnormal_social/conspecific_i0.63438639
91MP0003385_abnormal_body_wall0.62668047
92MP0010234_abnormal_vibrissa_follicle0.61857366
93MP0009697_abnormal_copulation0.60773051
94MP0005195_abnormal_posterior_eye0.60510203
95MP0001270_distended_abdomen0.58662525
96MP0002653_abnormal_ependyma_morphology0.57794619
97MP0002127_abnormal_cardiovascular_syste0.56859344
98MP0003880_abnormal_central_pattern0.56566757
99MP0008877_abnormal_DNA_methylation0.56300951
100MP0003941_abnormal_skin_development0.56235223

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the uterus (HP:0000013)6.17562141
2Abnormal sex determination (HP:0012244)5.99541402
3Sex reversal (HP:0012245)5.99541402
4Resting tremor (HP:0002322)5.71298920
5Male pseudohermaphroditism (HP:0000037)5.01310953
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.94543852
7Aplasia/hypoplasia of the uterus (HP:0008684)4.67639701
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.46715328
9Absent/shortened dynein arms (HP:0200106)4.46715328
10Abnormal respiratory motile cilium physiology (HP:0012261)4.42481531
11Gonadal dysgenesis (HP:0000133)4.42231122
12Abnormal ciliary motility (HP:0012262)4.29873251
13Reduced antithrombin III activity (HP:0001976)4.08272395
14Abnormality of the columella (HP:0009929)4.05299615
15Colitis (HP:0002583)4.05192442
16Postural instability (HP:0002172)3.64542019
17Cerebellar dysplasia (HP:0007033)3.62980514
18True hermaphroditism (HP:0010459)3.48922826
19Urinary urgency (HP:0000012)3.46691678
20Type II lissencephaly (HP:0007260)3.45765325
21Facial hemangioma (HP:0000329)3.44384496
22Absent rod-and cone-mediated responses on ERG (HP:0007688)3.42895502
23Abnormal respiratory epithelium morphology (HP:0012253)3.37506996
24Abnormal respiratory motile cilium morphology (HP:0005938)3.37506996
25Pancreatic cysts (HP:0001737)3.31131672
26Infertility (HP:0000789)3.22028139
27Ventricular fibrillation (HP:0001663)3.21590110
28Congenital sensorineural hearing impairment (HP:0008527)3.21334892
29Pancreatic fibrosis (HP:0100732)3.19915720
30Generalized aminoaciduria (HP:0002909)3.15491854
31Retinal dysplasia (HP:0007973)3.04790706
32Thoracic kyphosis (HP:0002942)3.04247399
33Germ cell neoplasia (HP:0100728)2.93542546
34Retinal atrophy (HP:0001105)2.91953439
35Cystic liver disease (HP:0006706)2.88704060
36Occipital encephalocele (HP:0002085)2.87568950
37Pendular nystagmus (HP:0012043)2.81610876
38Chronic hepatic failure (HP:0100626)2.77247935
39Abnormality of the lumbar spine (HP:0100712)2.72846485
40Protruding tongue (HP:0010808)2.69008323
41Facial diplegia (HP:0001349)2.61395600
42Proximal tubulopathy (HP:0000114)2.58472837
43Optic nerve hypoplasia (HP:0000609)2.58212922
44Acute lymphatic leukemia (HP:0006721)2.57702344
45Thoracolumbar scoliosis (HP:0002944)2.46639360
46Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.46203013
47Rhinitis (HP:0012384)2.46014258
48Inflammation of the large intestine (HP:0002037)2.44736406
49Median cleft lip (HP:0000161)2.44501707
50Abnormality of macular pigmentation (HP:0008002)2.40551742
51Chronic bronchitis (HP:0004469)2.39973867
52Inability to walk (HP:0002540)2.36812120
53Anencephaly (HP:0002323)2.35139008
54Capillary hemangiomas (HP:0005306)2.34359772
55Sensory axonal neuropathy (HP:0003390)2.34166677
56Bile duct proliferation (HP:0001408)2.32726499
57Abnormal biliary tract physiology (HP:0012439)2.32726499
58Attenuation of retinal blood vessels (HP:0007843)2.31970431
59Abnormal rod and cone electroretinograms (HP:0008323)2.13659021
60Renal dysplasia (HP:0000110)2.12389016
61Self-mutilation (HP:0000742)2.12018838
62Gastrointestinal inflammation (HP:0004386)2.09563533
63Progressive cerebellar ataxia (HP:0002073)2.07495774
64Abnormality of male internal genitalia (HP:0000022)2.06303688
65Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05304780
66Intellectual disability, progressive (HP:0006887)2.04413568
67Atonic seizures (HP:0010819)2.04158004
68Abnormality of the intrinsic pathway (HP:0010989)2.04125377
69Absent speech (HP:0001344)2.03430935
70Aplasia/Hypoplasia of the tongue (HP:0010295)2.02080893
71Abnormality of the frontal sinuses (HP:0002687)2.01946025
72Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.01850127
73Recurrent corneal erosions (HP:0000495)1.97506343
74Severe visual impairment (HP:0001141)1.96286729
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95710409
76Bronchiectasis (HP:0002110)1.93491460
77High anterior hairline (HP:0009890)1.91542581
78Rectovaginal fistula (HP:0000143)1.88191739
79Rectal fistula (HP:0100590)1.88191739
80Absent thumb (HP:0009777)1.86967734
81Aplasia cutis congenita (HP:0001057)1.86684550
82Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86062649
83Abnormal protein N-linked glycosylation (HP:0012347)1.86062649
84Abnormal protein glycosylation (HP:0012346)1.86062649
85Abnormal glycosylation (HP:0012345)1.86062649
86Abnormality of DNA repair (HP:0003254)1.85813369
87Unsteady gait (HP:0002317)1.83852843
88Abnormality of the ileum (HP:0001549)1.81552991
89Abolished electroretinogram (ERG) (HP:0000550)1.80682171
90Anterior segment dysgenesis (HP:0007700)1.79775330
91Postaxial foot polydactyly (HP:0001830)1.79494205
92Congenital stationary night blindness (HP:0007642)1.78552387
93Sclerocornea (HP:0000647)1.78120250
94Glycosuria (HP:0003076)1.77734783
95Abnormality of urine glucose concentration (HP:0011016)1.77734783
96Nasal polyposis (HP:0100582)1.77610636
97Popliteal pterygium (HP:0009756)1.77210760
98Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.76697435
99Aplasia/Hypoplasia of the uvula (HP:0010293)1.76626998
100Hypothermia (HP:0002045)1.75384558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK35.82299267
2FRK3.88723269
3ZAK3.63489257
4TLK13.51127511
5RPS6KA52.76742076
6MYLK2.61129918
7NEK22.13297408
8PINK110.6673407
9MAP2K71.83410948
10BMPR1B1.77023327
11LATS11.75358411
12CSNK1A1L1.52458210
13CSNK1G31.44515066
14CDK191.43331307
15FGFR21.30337961
16CDK31.25546459
17ADRBK21.25358863
18EPHA41.19955282
19CSNK1G21.17465638
20CSNK1G11.13248528
21STK38L1.04423213
22SGK2230.93133986
23SGK4940.93133986
24STK380.91194578
25DYRK30.88130113
26PKN10.86190320
27RPS6KA40.84379100
28OBSCN0.81377654
29PRKCQ0.77824536
30CDK140.72476573
31TGFBR10.70658344
32VRK10.65939737
33MAPK150.64239474
34CDC42BPA0.63624801
35MAPK130.63467630
36PDK20.63341961
37EPHA30.61687626
38FGR0.60954520
39GRK10.60034533
40DYRK20.59896875
41BCKDK0.56540889
42MAP3K50.56224009
43PIK3CA0.55889308
44TIE10.55106957
45PTK2B0.53911303
46MST1R0.52856719
47RPS6KB10.49807884
48DAPK30.48213450
49CSNK1A10.48073439
50LATS20.47322915
51SRPK10.47291232
52EGFR0.46533679
53TRIM280.45795047
54MAP4K10.44724274
55GRK60.44050425
56BCR0.42638821
57CDK50.41692386
58CAMK10.40067111
59AURKA0.39296050
60WNK30.39179125
61ROCK10.38920990
62PIM20.38846194
63STK390.38481201
64PAK10.38391625
65MAP3K40.38144126
66PRKG20.36398077
67MOS0.36342480
68TXK0.35916511
69BTK0.34083049
70ATM0.32713190
71GRK50.31660828
72PIM10.30171214
73FER0.30042425
74MELK0.28777518
75MAP4K20.28122981
76MAP3K90.27385649
77NTRK20.27181057
78RPS6KA30.26911343
79PAK30.25197160
80EIF2AK30.25156766
81SGK20.24463791
82CSNK1D0.23539038
83PAK20.22702618
84NEK60.21157673
85AKT20.21114657
86MAP3K10.21089411
87PRKG10.20847080
88PLK10.19919939
89CDK80.19345957
90PRKACB0.19333818
91RPS6KA10.18111775
92PDPK10.16571270
93PDK10.16110275
94PRKCE0.15598022
95INSRR0.14415991
96PRKAA10.13631766
97AURKB0.13606069
98ERBB30.13588309
99ICK0.13550333
100ARAF0.13351146

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051306.38621854
2Gap junction_Homo sapiens_hsa045404.40878839
3Nitrogen metabolism_Homo sapiens_hsa009103.80443038
4Butanoate metabolism_Homo sapiens_hsa006503.26921789
5Hedgehog signaling pathway_Homo sapiens_hsa043402.84175176
6Systemic lupus erythematosus_Homo sapiens_hsa053222.78959406
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72738798
8Propanoate metabolism_Homo sapiens_hsa006402.51805138
9Olfactory transduction_Homo sapiens_hsa047402.29288496
10Alcoholism_Homo sapiens_hsa050342.28550089
11Steroid hormone biosynthesis_Homo sapiens_hsa001402.28232443
12Phagosome_Homo sapiens_hsa041452.20705054
13Apoptosis_Homo sapiens_hsa042102.04087511
14Arginine biosynthesis_Homo sapiens_hsa002201.98094180
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75032874
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.70568503
17Chemical carcinogenesis_Homo sapiens_hsa052041.69624041
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.68099564
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.59626811
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58287842
21Taste transduction_Homo sapiens_hsa047421.52632475
22Phototransduction_Homo sapiens_hsa047441.48017911
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45829834
24Glutathione metabolism_Homo sapiens_hsa004801.39660776
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31038080
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21364434
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18533147
28Pyruvate metabolism_Homo sapiens_hsa006201.17534601
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.16307791
30Retinol metabolism_Homo sapiens_hsa008301.15363961
31Sulfur relay system_Homo sapiens_hsa041221.10811994
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.10004858
33Tryptophan metabolism_Homo sapiens_hsa003801.02008151
34Nicotine addiction_Homo sapiens_hsa050330.99494205
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99373766
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90535871
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89512486
38Selenocompound metabolism_Homo sapiens_hsa004500.87181085
39Peroxisome_Homo sapiens_hsa041460.86618221
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86563948
41PPAR signaling pathway_Homo sapiens_hsa033200.84355312
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83745988
43beta-Alanine metabolism_Homo sapiens_hsa004100.82314126
44Fanconi anemia pathway_Homo sapiens_hsa034600.80174222
45Renin-angiotensin system_Homo sapiens_hsa046140.79008128
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.76257666
47Renin secretion_Homo sapiens_hsa049240.75665853
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75435532
49Glucagon signaling pathway_Homo sapiens_hsa049220.66400182
50Calcium signaling pathway_Homo sapiens_hsa040200.64523554
51Circadian rhythm_Homo sapiens_hsa047100.64132345
52Fatty acid metabolism_Homo sapiens_hsa012120.64067552
53Fatty acid degradation_Homo sapiens_hsa000710.63975188
54GABAergic synapse_Homo sapiens_hsa047270.63061693
55Oocyte meiosis_Homo sapiens_hsa041140.62724100
56Dorso-ventral axis formation_Homo sapiens_hsa043200.61918460
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60911139
58Steroid biosynthesis_Homo sapiens_hsa001000.60887450
59Regulation of autophagy_Homo sapiens_hsa041400.60303772
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.55438817
61Circadian entrainment_Homo sapiens_hsa047130.55412578
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.54447975
63Vitamin digestion and absorption_Homo sapiens_hsa049770.54354416
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54216820
65Gastric acid secretion_Homo sapiens_hsa049710.51730865
66Linoleic acid metabolism_Homo sapiens_hsa005910.51688975
67Caffeine metabolism_Homo sapiens_hsa002320.51553487
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51490244
69Starch and sucrose metabolism_Homo sapiens_hsa005000.51284729
70Oxytocin signaling pathway_Homo sapiens_hsa049210.51173840
71Basal transcription factors_Homo sapiens_hsa030220.50536186
72mRNA surveillance pathway_Homo sapiens_hsa030150.49795988
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46627686
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46486184
75Arginine and proline metabolism_Homo sapiens_hsa003300.44879196
76ABC transporters_Homo sapiens_hsa020100.42171290
77Glycerolipid metabolism_Homo sapiens_hsa005610.39974575
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39547945
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39049922
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.38616338
81Metabolic pathways_Homo sapiens_hsa011000.38525963
82Fatty acid biosynthesis_Homo sapiens_hsa000610.37207631
83Homologous recombination_Homo sapiens_hsa034400.35939973
84Purine metabolism_Homo sapiens_hsa002300.35875494
85Morphine addiction_Homo sapiens_hsa050320.35796240
86TGF-beta signaling pathway_Homo sapiens_hsa043500.34545747
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34221798
88Sphingolipid metabolism_Homo sapiens_hsa006000.32524410
89Arachidonic acid metabolism_Homo sapiens_hsa005900.31689832
90Cocaine addiction_Homo sapiens_hsa050300.30888532
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30692793
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30611869
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30017219
94Amphetamine addiction_Homo sapiens_hsa050310.26223073
95Glutamatergic synapse_Homo sapiens_hsa047240.24395146
96Fat digestion and absorption_Homo sapiens_hsa049750.21349442
97Lysine degradation_Homo sapiens_hsa003100.20642846
98Tyrosine metabolism_Homo sapiens_hsa003500.18198418
99RNA degradation_Homo sapiens_hsa030180.17587792
100Salivary secretion_Homo sapiens_hsa049700.16965377

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