OGDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.65569230
2* tricarboxylic acid cycle (GO:0006099)6.57761379
3cardiac myofibril assembly (GO:0055003)6.07209591
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.06436665
5carnitine shuttle (GO:0006853)6.03570298
6negative regulation of potassium ion transmembrane transport (GO:1901380)5.67665549
7regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.46348134
8myofibril assembly (GO:0030239)5.40712970
9fatty acid transmembrane transport (GO:1902001)5.39956484
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.19067967
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.17682773
12cardiac muscle contraction (GO:0060048)5.16459362
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.04960437
14plasma membrane repair (GO:0001778)4.99229701
15regulation of acyl-CoA biosynthetic process (GO:0050812)4.93400182
16actin-myosin filament sliding (GO:0033275)4.91419528
17muscle filament sliding (GO:0030049)4.91419528
18carnitine transmembrane transport (GO:1902603)4.71579016
19regulation of actin filament-based movement (GO:1903115)4.69937915
20ventricular cardiac muscle cell action potential (GO:0086005)4.66987615
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.66536207
22regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.62911356
23bundle of His cell to Purkinje myocyte communication (GO:0086069)4.59430426
24carnitine transport (GO:0015879)4.57801494
25amino-acid betaine transport (GO:0015838)4.57801494
26regulation of coenzyme metabolic process (GO:0051196)4.54273881
27regulation of cofactor metabolic process (GO:0051193)4.54273881
28regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.53090619
29fatty acid beta-oxidation (GO:0006635)4.39855114
30regulation of sequestering of triglyceride (GO:0010889)4.38443758
31cardiac muscle cell development (GO:0055013)4.38055225
32skeletal muscle contraction (GO:0003009)4.33492752
33cell communication involved in cardiac conduction (GO:0086065)4.33002440
34actomyosin structure organization (GO:0031032)4.26147878
35regulation of skeletal muscle contraction (GO:0014819)4.25362890
36regulation of relaxation of muscle (GO:1901077)4.23806297
37tricarboxylic acid metabolic process (GO:0072350)4.23533659
38regulation of fatty acid oxidation (GO:0046320)4.10290360
39cardiac cell development (GO:0055006)4.08169750
40actin-mediated cell contraction (GO:0070252)4.07558855
41regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.06327631
42succinate metabolic process (GO:0006105)4.05263153
43striated muscle contraction (GO:0006941)4.04891199
44sarcoplasmic reticulum calcium ion transport (GO:0070296)4.01992596
45cardiac muscle hypertrophy (GO:0003300)3.98442755
46cell communication by electrical coupling (GO:0010644)3.98125822
47response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.91616214
48skeletal muscle adaptation (GO:0043501)3.89175226
49oxaloacetate metabolic process (GO:0006107)3.89038719
50* 2-oxoglutarate metabolic process (GO:0006103)3.85909815
51striated muscle hypertrophy (GO:0014897)3.79104255
52regulation of membrane repolarization (GO:0060306)3.77450469
53cardiac muscle tissue morphogenesis (GO:0055008)3.77314567
54adult heart development (GO:0007512)3.76469610
55regulation of cell communication by electrical coupling (GO:0010649)3.73741740
56regulation of the force of heart contraction (GO:0002026)3.73028115
57regulation of striated muscle contraction (GO:0006942)3.71650707
58heart trabecula formation (GO:0060347)3.70570151
59* NADH metabolic process (GO:0006734)3.69206714
60fatty acid catabolic process (GO:0009062)3.67510627
61regulation of sulfur metabolic process (GO:0042762)3.66751298
62quaternary ammonium group transport (GO:0015697)3.63957508
63ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.63867469
64fatty acid oxidation (GO:0019395)3.62354016
65creatine metabolic process (GO:0006600)3.61409756
66lipid oxidation (GO:0034440)3.55473164
67relaxation of cardiac muscle (GO:0055119)3.50219037
68biotin metabolic process (GO:0006768)3.47808933
69regulation of cardiac muscle cell contraction (GO:0086004)3.45201737
70cell-substrate adherens junction assembly (GO:0007045)3.42358356
71focal adhesion assembly (GO:0048041)3.42358356
72regulation of sarcomere organization (GO:0060297)3.41404501
73acetyl-CoA metabolic process (GO:0006084)3.40962165
74muscle tissue morphogenesis (GO:0060415)3.39180102
75muscle hypertrophy (GO:0014896)3.30832379
76positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.29675679
77cardiac muscle cell action potential involved in contraction (GO:0086002)3.27225683
78valine metabolic process (GO:0006573)3.26050471
79cytoskeletal anchoring at plasma membrane (GO:0007016)3.25595010
80* aspartate family amino acid catabolic process (GO:0009068)3.25086232
81positive regulation of fatty acid oxidation (GO:0046321)3.22750455
82actin filament-based movement (GO:0030048)3.22570622
83cardiac muscle cell action potential (GO:0086001)3.21095128
84branched-chain amino acid catabolic process (GO:0009083)3.20983187
85adherens junction assembly (GO:0034333)3.20975659
86short-chain fatty acid metabolic process (GO:0046459)3.20412424
87negative regulation of potassium ion transport (GO:0043267)3.17992127
88* lysine metabolic process (GO:0006553)3.16393546
89* lysine catabolic process (GO:0006554)3.16393546
90barbed-end actin filament capping (GO:0051016)3.15969630
91regulation of cardiac muscle contraction (GO:0055117)3.15847978
92striated muscle atrophy (GO:0014891)3.15562008
93regulation of heart rate (GO:0002027)3.15456556
94heart process (GO:0003015)3.14507799
95heart contraction (GO:0060047)3.14507799
96oxidative phosphorylation (GO:0006119)3.14383681
97branched-chain amino acid metabolic process (GO:0009081)3.13199007
98intracellular lipid transport (GO:0032365)3.13087655
99protein localization to endosome (GO:0036010)3.12628014
100cardiac conduction (GO:0061337)3.10137514
101cellular response to epinephrine stimulus (GO:0071872)3.09043674
102carnitine metabolic process (GO:0009437)3.08247348
103negative regulation of necroptotic process (GO:0060546)3.06225971
104cell-substrate junction assembly (GO:0007044)3.06059159
105monocarboxylic acid catabolic process (GO:0072329)3.04499850
106positive regulation of fatty acid beta-oxidation (GO:0032000)3.04401702
107regulation of heart rate by cardiac conduction (GO:0086091)3.03791273
108cardiac muscle adaptation (GO:0014887)3.02058273
109cardiac muscle hypertrophy in response to stress (GO:0014898)3.02058273
110muscle hypertrophy in response to stress (GO:0003299)3.02058273
111positive regulation of myotube differentiation (GO:0010831)3.01718987
112COPI coating of Golgi vesicle (GO:0048205)3.00268430
113Golgi transport vesicle coating (GO:0048200)3.00268430
114striated muscle adaptation (GO:0014888)2.98291628
115muscle contraction (GO:0006936)2.97940878
116negative regulation of cytosolic calcium ion concentration (GO:0051481)2.95018500
117response to inactivity (GO:0014854)2.94391979
118regulation of heart contraction (GO:0008016)2.90627605
119membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.89132491
120glycogen catabolic process (GO:0005980)2.88670889
121negative regulation of cell size (GO:0045792)2.86226814
122glucan catabolic process (GO:0009251)2.85431567
123desmosome organization (GO:0002934)2.83168811
124fructose metabolic process (GO:0006000)2.80658980
125retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.78513660
126negative regulation of erythrocyte differentiation (GO:0045647)2.78293849
127regulation of necroptotic process (GO:0060544)2.77774964
128gluconeogenesis (GO:0006094)2.76649582
129epithelial cell-cell adhesion (GO:0090136)2.76170937
130response to epinephrine (GO:0071871)2.72567060
131response to muscle activity (GO:0014850)2.69403318
132cellular polysaccharide catabolic process (GO:0044247)2.66758585
133muscle system process (GO:0003012)2.65423751
134pinocytosis (GO:0006907)2.62298644
135muscle atrophy (GO:0014889)2.61094576
136muscle adaptation (GO:0043500)2.59057439
137stress fiber assembly (GO:0043149)2.59048700
138sodium ion export (GO:0071436)2.59033173
139regulation of early endosome to late endosome transport (GO:2000641)2.56651777
140hexose biosynthetic process (GO:0019319)2.56635567
141negative regulation of myotube differentiation (GO:0010832)2.53830604
142negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.53691487
143positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.53218874
144regulation of glucose import in response to insulin stimulus (GO:2001273)2.53117338
145positive regulation of receptor recycling (GO:0001921)2.52162862
146response to mercury ion (GO:0046689)2.49060288
147monosaccharide biosynthetic process (GO:0046364)2.41324354
148activation of protein kinase A activity (GO:0034199)2.39132877
149polysaccharide catabolic process (GO:0000272)2.38891994
150regulation of necrotic cell death (GO:0010939)2.35658736
151protein targeting to plasma membrane (GO:0072661)2.35128080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.38198783
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.89567790
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.79249476
4* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.43797946
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.13936008
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.95638011
7TBX20_22080862_ChIP-Seq_HEART_Mouse2.85345482
8TBX20_22328084_ChIP-Seq_HEART_Mouse2.85345482
9ZNF263_19887448_ChIP-Seq_K562_Human2.75291962
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.65422995
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.65033299
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.49446829
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.45796154
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.38872350
15CLOCK_20551151_ChIP-Seq_293T_Human2.33693708
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30587472
17VDR_21846776_ChIP-Seq_THP-1_Human2.09397203
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05312294
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.04786923
20TCF7_22412390_ChIP-Seq_EML_Mouse2.04650364
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.04033317
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.98272649
23MYC_22102868_ChIP-Seq_BL_Human1.95884459
24GATA1_22025678_ChIP-Seq_K562_Human1.91158046
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.86180117
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73564931
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68204373
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65260502
29LXR_22292898_ChIP-Seq_THP-1_Human1.60194299
30MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.58906347
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.54084505
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52443080
33DROSHA_22980978_ChIP-Seq_HELA_Human1.49354106
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45774230
35PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43084609
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38768698
37CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37099304
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36806721
39* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36802395
40GATA1_19941826_ChIP-Seq_K562_Human1.35259102
41FOXA2_19822575_ChIP-Seq_HepG2_Human1.34596969
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34222812
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34104239
44KDM2B_26808549_Chip-Seq_DND41_Human1.33462572
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32572177
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32404491
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.31467127
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30299820
49MAF_26560356_Chip-Seq_TH1_Human1.29919393
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29722541
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29529288
52* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28936259
53VDR_24763502_ChIP-Seq_THP-1_Human1.28813818
54RACK7_27058665_Chip-Seq_MCF-7_Human1.28248595
55GATA4_21415370_ChIP-Seq_HL-1_Mouse1.28149915
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26812372
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26175079
58KDM2B_26808549_Chip-Seq_JURKAT_Human1.26154085
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25370890
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24245082
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23141917
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21191364
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20484203
64* TET1_21451524_ChIP-Seq_MESCs_Mouse1.20106660
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18119713
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17460138
67P68_20966046_ChIP-Seq_HELA_Human1.16169706
68TP63_22573176_ChIP-Seq_HFKS_Human1.15901772
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14665253
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.14522676
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14351100
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.13797496
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.13633729
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.12962451
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12754155
76RUNX1_27514584_Chip-Seq_MCF-7_Human1.11449082
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11338082
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11269957
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11247502
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11242501
81ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11224389
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11110801
83CTCF_27219007_Chip-Seq_Bcells_Human1.10374563
84KDM2B_26808549_Chip-Seq_K562_Human1.10289677
85MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10209199
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09381799
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09305315
88GATA2_19941826_ChIP-Seq_K562_Human1.09225295
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09104101
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08550252
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.08466264
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.06953725
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05455358
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05332631
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05321408
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05245167
97STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04147035
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.04107098
99* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03674788
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02897709
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01729581
102* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00986290
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00640596
104ESR1_21235772_ChIP-Seq_MCF-7_Human1.00601201
105UTX_26944678_Chip-Seq_JUKART_Human1.00220933
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00009940
107ELK3_25401928_ChIP-Seq_HUVEC_Human0.99520740
108STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99174901
109* ATF3_27146783_Chip-Seq_COLON_Human0.98281757
110* RARB_27405468_Chip-Seq_BRAIN_Mouse0.98082909
111EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97857047
112EZH2_22144423_ChIP-Seq_EOC_Human0.96987770
113SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96975443
114TRIM28_21343339_ChIP-Seq_HEK293_Human0.96196840
115CREB1_26743006_Chip-Seq_LNCaP_Human0.95646793
116* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95159035
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.94916451
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92522868
119SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92514816
120GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.91937624
121SPI1_23127762_ChIP-Seq_K562_Human0.91802017
122* SMC4_20622854_ChIP-Seq_HELA_Human0.91787269
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91125674
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89618179
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89359330
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88706675
127BCOR_27268052_Chip-Seq_Bcells_Human0.88547783
128PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87539637
129KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87511318
130WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87313107
131FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.86386280
132RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86254291
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83409656
134WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82146332
135GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81552395
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81343294
137MTF2_20144788_ChIP-Seq_MESCs_Mouse0.80419108
138TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80199059
139SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80152062
140* BCL6_27268052_Chip-Seq_Bcells_Human0.79449084
141ISL1_27105846_Chip-Seq_CPCs_Mouse0.77712984
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.76526905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.45062890
2MP0003646_muscle_fatigue5.16462611
3MP0004084_abnormal_cardiac_muscle4.80847750
4MP0000751_myopathy4.57329369
5MP0004215_abnormal_myocardial_fiber4.02870774
6MP0005451_abnormal_body_composition4.00054757
7MP0004036_abnormal_muscle_relaxation3.75575238
8MP0005330_cardiomyopathy3.41939381
9MP0000749_muscle_degeneration3.26119851
10MP0004130_abnormal_muscle_cell3.14809329
11MP0004087_abnormal_muscle_fiber2.77383648
12MP0002972_abnormal_cardiac_muscle2.69911404
13MP0008775_abnormal_heart_ventricle2.57606388
14MP0005620_abnormal_muscle_contractility2.41524706
15MP0005670_abnormal_white_adipose2.40758195
16MP0003137_abnormal_impulse_conducting2.36480126
17MP0005385_cardiovascular_system_phenoty2.28644963
18MP0001544_abnormal_cardiovascular_syste2.28644963
19MP0000750_abnormal_muscle_regeneration2.23544530
20MP0005666_abnormal_adipose_tissue2.22868215
21MP0010630_abnormal_cardiac_muscle2.20697453
22MP0006138_congestive_heart_failure2.18989291
23MP0002269_muscular_atrophy2.15518507
24MP0002106_abnormal_muscle_physiology2.12856651
25MP0004484_altered_response_of2.07869507
26MP0010234_abnormal_vibrissa_follicle2.03605886
27MP0000747_muscle_weakness1.98798206
28MP0006036_abnormal_mitochondrial_physio1.96276243
29MP0004145_abnormal_muscle_electrophysio1.87523503
30MP0005058_abnormal_lysosome_morphology1.84781307
31MP0004085_abnormal_heartbeat1.84637858
32MP0004043_abnormal_pH_regulation1.81050642
33MP0003221_abnormal_cardiomyocyte_apopto1.76040491
34MP0000759_abnormal_skeletal_muscle1.74806158
35MP0005369_muscle_phenotype1.70050811
36MP0004233_abnormal_muscle_weight1.66934310
37MP0005375_adipose_tissue_phenotype1.63846997
38MP0003828_pulmonary_edema1.59391773
39MP0004185_abnormal_adipocyte_glucose1.57326130
40MP0005360_urolithiasis1.56282105
41MP0000733_abnormal_muscle_development1.56121658
42MP0004858_abnormal_nervous_system1.54220571
43MP0008260_abnormal_autophagy1.51917495
44MP0004510_myositis1.45651810
45MP0008961_abnormal_basal_metabolism1.40880369
46MP0000013_abnormal_adipose_tissue1.36061895
47MP0002909_abnormal_adrenal_gland1.33849251
48MP0005409_darkened_coat_color1.32779979
49MP0001849_ear_inflammation1.30482207
50MP0008438_abnormal_cutaneous_collagen1.29799123
51MP0003705_abnormal_hypodermis_morpholog1.29392089
52MP0002332_abnormal_exercise_endurance1.27934765
53MP0003091_abnormal_cell_migration1.27653665
54MP0000003_abnormal_adipose_tissue1.23849532
55MP0002971_abnormal_brown_adipose1.23599027
56MP0003453_abnormal_keratinocyte_physiol1.20505911
57MP0002796_impaired_skin_barrier1.12658778
58MP0009780_abnormal_chondrocyte_physiolo1.10566436
59MP0005332_abnormal_amino_acid1.09573936
60MP0004947_skin_inflammation1.08363251
61MP0002127_abnormal_cardiovascular_syste1.08041269
62MP0005085_abnormal_gallbladder_physiolo1.05521435
63MP0003303_peritoneal_inflammation1.05249563
64MP0009840_abnormal_foam_cell1.04522002
65MP0005535_abnormal_body_temperature1.04050072
66MP0005076_abnormal_cell_differentiation1.03457075
67MP0000230_abnormal_systemic_arterial1.02896472
68MP0010329_abnormal_lipoprotein_level1.00066355
69MP0002078_abnormal_glucose_homeostasis0.99975428
70MP0006035_abnormal_mitochondrial_morpho0.99492654
71MP0002118_abnormal_lipid_homeostasis0.98854242
72MP0003436_decreased_susceptibility_to0.98549071
73MP0002139_abnormal_hepatobiliary_system0.97298241
74MP0000343_altered_response_to0.96234340
75MP0001661_extended_life_span0.95240751
76MP0002234_abnormal_pharynx_morphology0.94939848
77MP0005165_increased_susceptibility_to0.94328285
78MP0003950_abnormal_plasma_membrane0.93492812
79MP0000266_abnormal_heart_morphology0.91848322
80MP0003075_altered_response_to0.91023535
81MP0005319_abnormal_enzyme/_coenzyme0.90594362
82MP0005365_abnormal_bile_salt0.88631733
83MP0005266_abnormal_metabolism0.88000505
84MP0003252_abnormal_bile_duct0.86949838
85MP0001958_emphysema0.86568620
86MP0003195_calcinosis0.85858913
87MP0010368_abnormal_lymphatic_system0.85852123
88MP0009643_abnormal_urine_homeostasis0.85268025
89MP0003879_abnormal_hair_cell0.83297749
90MP0004264_abnormal_extraembryonic_tissu0.82843077
91MP0005166_decreased_susceptibility_to0.81626642
92MP0005584_abnormal_enzyme/coenzyme_acti0.81619065
93MP0003191_abnormal_cellular_cholesterol0.81208303
94MP0010352_gastrointestinal_tract_polyps0.80814509
95MP0004147_increased_porphyrin_level0.80033103
96MP0003566_abnormal_cell_adhesion0.79962021
97MP0002822_catalepsy0.78988809
98MP0008004_abnormal_stomach_pH0.77596034
99MP0003183_abnormal_peptide_metabolism0.77114694
100MP0003806_abnormal_nucleotide_metabolis0.76858424
101MP0003279_aneurysm0.75347774
102MP0001765_abnormal_ion_homeostasis0.74734626
103MP0005334_abnormal_fat_pad0.74254482
104MP0002896_abnormal_bone_mineralization0.73202006
105MP0002998_abnormal_bone_remodeling0.73029757
106MP0001348_abnormal_lacrimal_gland0.71703423
107MP0000858_altered_metastatic_potential0.70862707
108MP0003656_abnormal_erythrocyte_physiolo0.70362066
109MP0002060_abnormal_skin_morphology0.69876156
110MP0004272_abnormal_basement_membrane0.69446272
111MP0002108_abnormal_muscle_morphology0.68039507
112MP0000604_amyloidosis0.67661467
113MP0000678_abnormal_parathyroid_gland0.67438101
114MP0008874_decreased_physiological_sensi0.66524578
115MP0005023_abnormal_wound_healing0.66373752
116MP0003567_abnormal_fetal_cardiomyocyte0.66269952
117MP0001666_abnormal_nutrient_absorption0.65705704
118MP0009115_abnormal_fat_cell0.64578342
119MP0001756_abnormal_urination0.63864380
120MP0000767_abnormal_smooth_muscle0.62189693
121MP0005448_abnormal_energy_balance0.61816634
122MP0003763_abnormal_thymus_physiology0.61109573
123MP0005501_abnormal_skin_physiology0.60962042
124MP0002970_abnormal_white_adipose0.60561107
125MP0005167_abnormal_blood-brain_barrier0.60470928
126MP0000609_abnormal_liver_physiology0.60387247
127MP0003045_fibrosis0.58980062
128MP0002128_abnormal_blood_circulation0.58978602
129MP0003329_amyloid_beta_deposits0.58111906
130MP0009278_abnormal_bone_marrow0.56510934
131MP0005187_abnormal_penis_morphology0.56223640
132MP0005083_abnormal_biliary_tract0.55529143
133MP0008875_abnormal_xenobiotic_pharmacok0.53294649
134MP0001879_abnormal_lymphatic_vessel0.49559892
135MP0003300_gastrointestinal_ulcer0.49105859
136MP0003283_abnormal_digestive_organ0.48380419
137MP0003953_abnormal_hormone_level0.45461089
138MP0005452_abnormal_adipose_tissue0.44307980
139MP0005275_abnormal_skin_tensile0.43490639
140MP0002877_abnormal_melanocyte_morpholog0.43108498

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.68436170
2Ventricular tachycardia (HP:0004756)5.63976873
3Nemaline bodies (HP:0003798)5.56091156
4Exercise-induced myalgia (HP:0003738)5.51956934
5Myoglobinuria (HP:0002913)5.42996059
6Exercise-induced muscle cramps (HP:0003710)5.16462894
7Calf muscle hypertrophy (HP:0008981)4.99796026
8Muscle fiber splitting (HP:0003555)4.77961771
9Atrial fibrillation (HP:0005110)4.73823934
10Muscle hypertrophy of the lower extremities (HP:0008968)4.58838186
11Right ventricular cardiomyopathy (HP:0011663)4.53861389
12Centrally nucleated skeletal muscle fibers (HP:0003687)4.51967442
13Primary atrial arrhythmia (HP:0001692)4.42693760
14Hyporeflexia of lower limbs (HP:0002600)4.40969600
15Supraventricular tachycardia (HP:0004755)4.25651589
16Lipoatrophy (HP:0100578)4.24782073
17Bundle branch block (HP:0011710)4.19409107
18Supraventricular arrhythmia (HP:0005115)4.18570797
19Syncope (HP:0001279)4.07952090
20Abnormality of the calf musculature (HP:0001430)4.07177642
21Palpitations (HP:0001962)4.07100569
22Rhabdomyolysis (HP:0003201)4.00232077
23Subaortic stenosis (HP:0001682)3.96222248
24Abnormality of the left ventricular outflow tract (HP:0011103)3.96222248
25Ketoacidosis (HP:0001993)3.89804012
26Myopathic facies (HP:0002058)3.84248187
27Distal lower limb amyotrophy (HP:0008944)3.78452121
28Hypoglycemic coma (HP:0001325)3.75646058
29Difficulty running (HP:0009046)3.74726427
30Dilated cardiomyopathy (HP:0001644)3.73174845
31Increased connective tissue (HP:0009025)3.70254711
32Asymmetric septal hypertrophy (HP:0001670)3.69077932
33Prolonged QT interval (HP:0001657)3.63894413
34Ventricular arrhythmia (HP:0004308)3.50201567
35Ventricular fibrillation (HP:0001663)3.46039280
36EMG: myopathic abnormalities (HP:0003458)3.40480659
37Abnormality of fatty-acid metabolism (HP:0004359)3.38812956
38Heart block (HP:0012722)3.38773989
39Atrioventricular block (HP:0001678)3.37606559
40Abnormal atrioventricular conduction (HP:0005150)3.16544588
41Ketosis (HP:0001946)3.10930627
42Myotonia (HP:0002486)3.02843829
43Hyperglycinuria (HP:0003108)3.01847669
44Dicarboxylic aciduria (HP:0003215)2.96922200
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.96922200
46Lower limb amyotrophy (HP:0007210)2.78468491
47Hepatic necrosis (HP:0002605)2.76842473
48Round ear (HP:0100830)2.74712566
49Muscle stiffness (HP:0003552)2.69849372
50Ulnar deviation of the wrist (HP:0003049)2.68256691
51Difficulty climbing stairs (HP:0003551)2.67923037
52Abnormal EKG (HP:0003115)2.66410528
53Increased muscle lipid content (HP:0009058)2.63231268
54Bulbar palsy (HP:0001283)2.59245325
55Conjunctival hamartoma (HP:0100780)2.58542807
56Hyperammonemia (HP:0001987)2.54258714
57Distal arthrogryposis (HP:0005684)2.51918544
58Generalized aminoaciduria (HP:0002909)2.49293721
59Increased variability in muscle fiber diameter (HP:0003557)2.48943490
60Pheochromocytoma (HP:0002666)2.47997972
61Dysmetric saccades (HP:0000641)2.46731403
62Foot dorsiflexor weakness (HP:0009027)2.46608526
63Abnormality of glycine metabolism (HP:0010895)2.44516774
64Abnormality of serine family amino acid metabolism (HP:0010894)2.44516774
65Hyperinsulinemic hypoglycemia (HP:0000825)2.43367728
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.42896562
67Abnormality of the foot musculature (HP:0001436)2.41782484
68Spinal rigidity (HP:0003306)2.40598195
69Frequent falls (HP:0002359)2.31912389
70Hamartoma of the eye (HP:0010568)2.30123231
71Rimmed vacuoles (HP:0003805)2.29932323
72Left ventricular hypertrophy (HP:0001712)2.29405699
73Scapular winging (HP:0003691)2.29253085
74Ragged-red muscle fibers (HP:0003200)2.29166275
75Achilles tendon contracture (HP:0001771)2.27664219
76Abnormality of skeletal muscle fiber size (HP:0012084)2.26324349
77Type 1 muscle fiber predominance (HP:0003803)2.25297839
78Limb-girdle muscle atrophy (HP:0003797)2.21664945
79Abnormal mitochondria in muscle tissue (HP:0008316)2.17964828
80Gout (HP:0001997)2.12254042
81Neuroendocrine neoplasm (HP:0100634)2.10882619
82Facial diplegia (HP:0001349)2.10657256
83Cerebral aneurysm (HP:0004944)2.09107589
84Cerebral edema (HP:0002181)2.06012961
85Palmoplantar keratoderma (HP:0000982)2.05661581
86Hepatocellular necrosis (HP:0001404)2.04681338
87Lymphangioma (HP:0100764)2.03408563
88Abnormality of the Achilles tendon (HP:0005109)2.02469074
89Acute encephalopathy (HP:0006846)2.01102751
90Distal lower limb muscle weakness (HP:0009053)2.01029170
91Testicular atrophy (HP:0000029)1.99646060
92Neck muscle weakness (HP:0000467)1.98706462
93Athetosis (HP:0002305)1.97280078
94Progressive muscle weakness (HP:0003323)1.96927059
95Neoplasm of the adrenal gland (HP:0100631)1.96887498
96Large for gestational age (HP:0001520)1.96301711
97Proximal tubulopathy (HP:0000114)1.96118427
98Sudden cardiac death (HP:0001645)1.95665861
99Muscle fiber inclusion bodies (HP:0100299)1.95224642
100Cholelithiasis (HP:0001081)1.90755841
101Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.90255389
102Increased intramyocellular lipid droplets (HP:0012240)1.89963999
103Central scotoma (HP:0000603)1.88954314
104Upper limb amyotrophy (HP:0009129)1.88655300
105Distal upper limb amyotrophy (HP:0007149)1.88655300
106Hyperacusis (HP:0010780)1.87852095
107EMG: neuropathic changes (HP:0003445)1.86884910
108Generalized muscle weakness (HP:0003324)1.86464904
109Hyperglycemia (HP:0003074)1.86208302
110Esophageal neoplasm (HP:0100751)1.86126928
111Neoplasm of head and neck (HP:0012288)1.86126928
112Acute necrotizing encephalopathy (HP:0006965)1.84612204
113Areflexia of lower limbs (HP:0002522)1.83761134
114Mildly elevated creatine phosphokinase (HP:0008180)1.83434225
115Vertebral compression fractures (HP:0002953)1.82837741
116Congestive heart failure (HP:0001635)1.80421313
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.79310670
118Osteolytic defects of the hand bones (HP:0009699)1.79310670
119Late onset (HP:0003584)1.76777852
120Insulin-resistant diabetes mellitus (HP:0000831)1.76521542
121Nausea (HP:0002018)1.75588909
122Axonal loss (HP:0003447)1.75270235
123* Lactic acidosis (HP:0003128)1.73652256
124Tinnitus (HP:0000360)1.73412325
125Protrusio acetabuli (HP:0003179)1.72864380
126Neonatal death (HP:0003811)1.72744827
127* Metabolic acidosis (HP:0001942)1.72726667
128Slender build (HP:0001533)1.70839104
129Obstructive sleep apnea (HP:0002870)1.69588374
130Aneurysm (HP:0002617)1.69012574
131Calcaneovalgus deformity (HP:0001848)1.68237053
132Generalized amyotrophy (HP:0003700)1.62807352
133Gowers sign (HP:0003391)1.62229636
134Broad face (HP:0000283)1.60200939
135Eczematoid dermatitis (HP:0000976)1.58864152
136Back pain (HP:0003418)1.58820354
137Cerebral inclusion bodies (HP:0100314)1.56317986
138Easy fatigability (HP:0003388)1.55736410
139Fatigue (HP:0012378)1.54022806
140Flat acetabular roof (HP:0003180)1.53919205
141Muscular dystrophy (HP:0003560)1.51053565
142Malignant hyperthermia (HP:0002047)1.50081723
143Premature rupture of membranes (HP:0001788)1.49561771
144Thin bony cortex (HP:0002753)1.48425643
145Abnormality of the tricuspid valve (HP:0001702)1.47878998
146Hemorrhage of the eye (HP:0011885)1.47106710
147Diaphragmatic weakness (HP:0009113)1.45807087
148Abnormality of the calcaneus (HP:0008364)1.45646728
149Rapidly progressive (HP:0003678)1.45109898
150Hyperkalemia (HP:0002153)1.43589168
151Advanced eruption of teeth (HP:0006288)1.41844220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.85452618
2LMTK24.04270909
3TRIB33.90210467
4PDK43.58622443
5PDK33.58622443
6PHKG13.43085164
7PHKG23.43085164
8BCKDK3.32214787
9PKN23.08488215
10OBSCN3.02150346
11PRPF4B2.92823324
12MYLK2.67907527
13NEK12.42618412
14PDK22.28852892
15DMPK2.28058330
16SMG12.22098134
17WNK41.87281586
18PINK11.74795760
19TIE11.67744732
20EPHA21.63312097
21IRAK31.55691328
22RIPK11.50149827
23PIK3CA1.45437275
24CDK121.34957678
25TESK11.34716338
26INSRR1.31660618
27PAK31.30032016
28MAP3K71.29981122
29MAP3K131.24924099
30STK241.19755234
31ERN11.14850408
32PRKD11.14269162
33SIK11.13476635
34TAOK21.10884333
35TESK21.09386812
36PDGFRA1.06938310
37PRKD31.03974779
38PRKAA11.03886996
39LATS21.03511121
40CAMK1D1.03017009
41ARAF1.02024332
42PRKAA21.01196251
43MUSK0.99948082
44TBK10.96025713
45PTK60.93904021
46SCYL20.91599524
47CAMK2D0.90546858
48STK380.90502417
49ZAP700.88398112
50CDC42BPA0.86806381
51LIMK10.83401697
52FGFR40.83378291
53ILK0.82639972
54CAMK1G0.81658083
55MAP2K30.81318282
56PRKCH0.81162819
57WNK10.80682294
58MAP3K60.80659934
59MARK20.80611538
60MOS0.80043433
61PDPK10.79404838
62MAPK120.79324376
63MAPKAPK30.78380838
64MAP3K110.78079138
65ROCK10.76286318
66FLT30.75462437
67RIPK40.75117800
68EPHB10.74858789
69GRK70.73778247
70PIK3CG0.72963033
71PAK40.72536198
72PDK10.67343610
73TYK20.67025488
74CAMK40.65622550
75PRKD20.65311652
76PTK20.65235657
77RET0.64836737
78MET0.64376138
79SGK30.64288201
80TGFBR20.64060728
81KSR20.61025573
82MAP3K50.59050158
83ICK0.57977232
84MAP4K10.57792260
85MAPK40.56927378
86TAOK10.56783024
87PRKACG0.55554906
88MAP3K140.54976017
89MAP3K30.54933102
90JAK10.54807739
91MAPK70.52517691
92MAP2K20.49605862
93CAMK10.48389422
94PAK60.48130311
95MAP2K40.46874087
96BLK0.46519509
97MAP3K100.46074677
98LRRK20.46070558
99NEK90.45542711
100EPHA30.44832642
101DAPK30.44758969
102FER0.43722815
103KDR0.43226450
104PRKG20.42661203
105MAP3K10.42438949
106PTK2B0.41514589
107MAP3K80.41224693
108STK38L0.40556722
109PRKACB0.40396904
110NTRK10.40207185
111JAK20.39852928
112NME20.39511859
113CAMKK10.38875266
114MAPK110.38736693
115JAK30.38126131
116HIPK20.37930397
117STK390.37450251
118MTOR0.37322048
119ROCK20.37283161
120EEF2K0.36726663
121RPS6KL10.35690349
122RPS6KC10.35690349
123MAP3K90.35553308
124DYRK1B0.34654767
125STK40.34381938
126CAMK2A0.34098592
127WNK30.33609108
128PRKACA0.33285280
129CAMK2G0.31582649
130FGFR30.31373427
131MAP2K10.30351290
132AKT20.29720851
133RPS6KA60.28890703
134PRKCE0.28074417
135TRPM70.27632466
136RPS6KA20.27616641
137PKN10.27084767
138MST1R0.26658696
139SGK2230.26549166
140SGK4940.26549166

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.50857688
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.33100457
3Propanoate metabolism_Homo sapiens_hsa006403.60505182
4Fatty acid degradation_Homo sapiens_hsa000713.35182230
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.10608999
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.85404287
7Fatty acid metabolism_Homo sapiens_hsa012122.74279701
8Cardiac muscle contraction_Homo sapiens_hsa042602.58822889
9* Carbon metabolism_Homo sapiens_hsa012002.41654406
10Dilated cardiomyopathy_Homo sapiens_hsa054142.37443761
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.22859289
12Pyruvate metabolism_Homo sapiens_hsa006202.16825577
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10087112
14Butanoate metabolism_Homo sapiens_hsa006501.97058027
15PPAR signaling pathway_Homo sapiens_hsa033201.85063656
16Other glycan degradation_Homo sapiens_hsa005111.66156924
17Parkinsons disease_Homo sapiens_hsa050121.61733333
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54624474
19Oxidative phosphorylation_Homo sapiens_hsa001901.47590201
20Starch and sucrose metabolism_Homo sapiens_hsa005001.36020618
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35526097
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31523464
23Arginine biosynthesis_Homo sapiens_hsa002201.27496647
24Fatty acid elongation_Homo sapiens_hsa000621.25975920
25Biosynthesis of amino acids_Homo sapiens_hsa012301.25261451
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23348959
27Alzheimers disease_Homo sapiens_hsa050101.21400218
28Fatty acid biosynthesis_Homo sapiens_hsa000611.21321567
29Insulin resistance_Homo sapiens_hsa049311.20938536
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20565366
31Acute myeloid leukemia_Homo sapiens_hsa052211.19215975
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.17654571
33Prion diseases_Homo sapiens_hsa050201.16645346
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.16074557
35beta-Alanine metabolism_Homo sapiens_hsa004101.14859595
36* Tryptophan metabolism_Homo sapiens_hsa003801.14622170
37Nitrogen metabolism_Homo sapiens_hsa009101.12943948
38Chronic myeloid leukemia_Homo sapiens_hsa052201.11610884
39Glucagon signaling pathway_Homo sapiens_hsa049221.11542292
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08709451
41Non-small cell lung cancer_Homo sapiens_hsa052231.02701901
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.01609666
43Endometrial cancer_Homo sapiens_hsa052131.00013115
44Fat digestion and absorption_Homo sapiens_hsa049750.97749532
45Insulin signaling pathway_Homo sapiens_hsa049100.96614930
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94632172
47Peroxisome_Homo sapiens_hsa041460.94517849
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92713228
49AMPK signaling pathway_Homo sapiens_hsa041520.90531765
50Pancreatic cancer_Homo sapiens_hsa052120.89368252
51B cell receptor signaling pathway_Homo sapiens_hsa046620.88210133
52Renal cell carcinoma_Homo sapiens_hsa052110.88099264
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87688932
54Type II diabetes mellitus_Homo sapiens_hsa049300.87668095
55Bile secretion_Homo sapiens_hsa049760.86944938
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86341311
57Viral myocarditis_Homo sapiens_hsa054160.85605320
58Bladder cancer_Homo sapiens_hsa052190.85522019
59Long-term potentiation_Homo sapiens_hsa047200.83884944
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.82446033
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82037969
62Thyroid cancer_Homo sapiens_hsa052160.81486645
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80604898
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80099842
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79517024
66Galactose metabolism_Homo sapiens_hsa000520.79374207
67Adherens junction_Homo sapiens_hsa045200.79366311
68Huntingtons disease_Homo sapiens_hsa050160.79096847
69Osteoclast differentiation_Homo sapiens_hsa043800.78555697
70* Lysine degradation_Homo sapiens_hsa003100.76746069
71Glycerolipid metabolism_Homo sapiens_hsa005610.75262292
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.75213975
73Glioma_Homo sapiens_hsa052140.74931659
74Fructose and mannose metabolism_Homo sapiens_hsa000510.74631048
75Notch signaling pathway_Homo sapiens_hsa043300.73728362
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73149431
77Toxoplasmosis_Homo sapiens_hsa051450.70405380
78Inositol phosphate metabolism_Homo sapiens_hsa005620.68478152
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67627825
80Phenylalanine metabolism_Homo sapiens_hsa003600.66914302
81Estrogen signaling pathway_Homo sapiens_hsa049150.66770301
82Hepatitis C_Homo sapiens_hsa051600.66296592
83Gastric acid secretion_Homo sapiens_hsa049710.65506105
84Proteoglycans in cancer_Homo sapiens_hsa052050.65254396
85Insulin secretion_Homo sapiens_hsa049110.65189556
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64651736
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.64565951
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61530568
89Renin secretion_Homo sapiens_hsa049240.61458032
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60533526
91Small cell lung cancer_Homo sapiens_hsa052220.59829367
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59738791
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59191568
94Lysosome_Homo sapiens_hsa041420.59024100
95ErbB signaling pathway_Homo sapiens_hsa040120.58997638
96Platelet activation_Homo sapiens_hsa046110.57686582
97Arginine and proline metabolism_Homo sapiens_hsa003300.54950876
98ECM-receptor interaction_Homo sapiens_hsa045120.54325860
99Endocytosis_Homo sapiens_hsa041440.54049330
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.53036237
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52167913
102Renin-angiotensin system_Homo sapiens_hsa046140.50643270
103Prolactin signaling pathway_Homo sapiens_hsa049170.50382618
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49450367
105Calcium signaling pathway_Homo sapiens_hsa040200.48415556
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47866635
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47711950
108Choline metabolism in cancer_Homo sapiens_hsa052310.47309383
109Leishmaniasis_Homo sapiens_hsa051400.46435839
110Oxytocin signaling pathway_Homo sapiens_hsa049210.46007375
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45939899
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45432228
113ABC transporters_Homo sapiens_hsa020100.45163194
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44213549
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.44128360
116HIF-1 signaling pathway_Homo sapiens_hsa040660.42585534
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42502675
118Focal adhesion_Homo sapiens_hsa045100.42036355
119Caffeine metabolism_Homo sapiens_hsa002320.41528216
120cAMP signaling pathway_Homo sapiens_hsa040240.37496217
121Sulfur metabolism_Homo sapiens_hsa009200.34021056
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33735443
123Tyrosine metabolism_Homo sapiens_hsa003500.31728747
124Pentose phosphate pathway_Homo sapiens_hsa000300.31127597
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.30790371
126Pancreatic secretion_Homo sapiens_hsa049720.28812383
127Circadian entrainment_Homo sapiens_hsa047130.27490199
128Tight junction_Homo sapiens_hsa045300.27175265
129mTOR signaling pathway_Homo sapiens_hsa041500.26948625
130Salivary secretion_Homo sapiens_hsa049700.26825938
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25816925
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.25080541
133Protein digestion and absorption_Homo sapiens_hsa049740.24539374
134Thyroid hormone synthesis_Homo sapiens_hsa049180.21728330
135Circadian rhythm_Homo sapiens_hsa047100.20567958
136Amoebiasis_Homo sapiens_hsa051460.19764907
137GnRH signaling pathway_Homo sapiens_hsa049120.18063912
138* Metabolic pathways_Homo sapiens_hsa011000.17152955
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.16337636
140Cholinergic synapse_Homo sapiens_hsa047250.15805191
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15524569
142VEGF signaling pathway_Homo sapiens_hsa043700.15415611
143Gap junction_Homo sapiens_hsa045400.14301103
144Dorso-ventral axis formation_Homo sapiens_hsa043200.13910456
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.12629758

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »