Rank | Gene Set | Z-score |
---|---|---|
1 | sarcomere organization (GO:0045214) | 6.65569230 |
2 | * tricarboxylic acid cycle (GO:0006099) | 6.57761379 |
3 | cardiac myofibril assembly (GO:0055003) | 6.07209591 |
4 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 6.06436665 |
5 | carnitine shuttle (GO:0006853) | 6.03570298 |
6 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 5.67665549 |
7 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 5.46348134 |
8 | myofibril assembly (GO:0030239) | 5.40712970 |
9 | fatty acid transmembrane transport (GO:1902001) | 5.39956484 |
10 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 5.19067967 |
11 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 5.17682773 |
12 | cardiac muscle contraction (GO:0060048) | 5.16459362 |
13 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 5.04960437 |
14 | plasma membrane repair (GO:0001778) | 4.99229701 |
15 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 4.93400182 |
16 | actin-myosin filament sliding (GO:0033275) | 4.91419528 |
17 | muscle filament sliding (GO:0030049) | 4.91419528 |
18 | carnitine transmembrane transport (GO:1902603) | 4.71579016 |
19 | regulation of actin filament-based movement (GO:1903115) | 4.69937915 |
20 | ventricular cardiac muscle cell action potential (GO:0086005) | 4.66987615 |
21 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 4.66536207 |
22 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 4.62911356 |
23 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 4.59430426 |
24 | carnitine transport (GO:0015879) | 4.57801494 |
25 | amino-acid betaine transport (GO:0015838) | 4.57801494 |
26 | regulation of coenzyme metabolic process (GO:0051196) | 4.54273881 |
27 | regulation of cofactor metabolic process (GO:0051193) | 4.54273881 |
28 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 4.53090619 |
29 | fatty acid beta-oxidation (GO:0006635) | 4.39855114 |
30 | regulation of sequestering of triglyceride (GO:0010889) | 4.38443758 |
31 | cardiac muscle cell development (GO:0055013) | 4.38055225 |
32 | skeletal muscle contraction (GO:0003009) | 4.33492752 |
33 | cell communication involved in cardiac conduction (GO:0086065) | 4.33002440 |
34 | actomyosin structure organization (GO:0031032) | 4.26147878 |
35 | regulation of skeletal muscle contraction (GO:0014819) | 4.25362890 |
36 | regulation of relaxation of muscle (GO:1901077) | 4.23806297 |
37 | tricarboxylic acid metabolic process (GO:0072350) | 4.23533659 |
38 | regulation of fatty acid oxidation (GO:0046320) | 4.10290360 |
39 | cardiac cell development (GO:0055006) | 4.08169750 |
40 | actin-mediated cell contraction (GO:0070252) | 4.07558855 |
41 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 4.06327631 |
42 | succinate metabolic process (GO:0006105) | 4.05263153 |
43 | striated muscle contraction (GO:0006941) | 4.04891199 |
44 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 4.01992596 |
45 | cardiac muscle hypertrophy (GO:0003300) | 3.98442755 |
46 | cell communication by electrical coupling (GO:0010644) | 3.98125822 |
47 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 3.91616214 |
48 | skeletal muscle adaptation (GO:0043501) | 3.89175226 |
49 | oxaloacetate metabolic process (GO:0006107) | 3.89038719 |
50 | * 2-oxoglutarate metabolic process (GO:0006103) | 3.85909815 |
51 | striated muscle hypertrophy (GO:0014897) | 3.79104255 |
52 | regulation of membrane repolarization (GO:0060306) | 3.77450469 |
53 | cardiac muscle tissue morphogenesis (GO:0055008) | 3.77314567 |
54 | adult heart development (GO:0007512) | 3.76469610 |
55 | regulation of cell communication by electrical coupling (GO:0010649) | 3.73741740 |
56 | regulation of the force of heart contraction (GO:0002026) | 3.73028115 |
57 | regulation of striated muscle contraction (GO:0006942) | 3.71650707 |
58 | heart trabecula formation (GO:0060347) | 3.70570151 |
59 | * NADH metabolic process (GO:0006734) | 3.69206714 |
60 | fatty acid catabolic process (GO:0009062) | 3.67510627 |
61 | regulation of sulfur metabolic process (GO:0042762) | 3.66751298 |
62 | quaternary ammonium group transport (GO:0015697) | 3.63957508 |
63 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 3.63867469 |
64 | fatty acid oxidation (GO:0019395) | 3.62354016 |
65 | creatine metabolic process (GO:0006600) | 3.61409756 |
66 | lipid oxidation (GO:0034440) | 3.55473164 |
67 | relaxation of cardiac muscle (GO:0055119) | 3.50219037 |
68 | biotin metabolic process (GO:0006768) | 3.47808933 |
69 | regulation of cardiac muscle cell contraction (GO:0086004) | 3.45201737 |
70 | cell-substrate adherens junction assembly (GO:0007045) | 3.42358356 |
71 | focal adhesion assembly (GO:0048041) | 3.42358356 |
72 | regulation of sarcomere organization (GO:0060297) | 3.41404501 |
73 | acetyl-CoA metabolic process (GO:0006084) | 3.40962165 |
74 | muscle tissue morphogenesis (GO:0060415) | 3.39180102 |
75 | muscle hypertrophy (GO:0014896) | 3.30832379 |
76 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.29675679 |
77 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.27225683 |
78 | valine metabolic process (GO:0006573) | 3.26050471 |
79 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.25595010 |
80 | * aspartate family amino acid catabolic process (GO:0009068) | 3.25086232 |
81 | positive regulation of fatty acid oxidation (GO:0046321) | 3.22750455 |
82 | actin filament-based movement (GO:0030048) | 3.22570622 |
83 | cardiac muscle cell action potential (GO:0086001) | 3.21095128 |
84 | branched-chain amino acid catabolic process (GO:0009083) | 3.20983187 |
85 | adherens junction assembly (GO:0034333) | 3.20975659 |
86 | short-chain fatty acid metabolic process (GO:0046459) | 3.20412424 |
87 | negative regulation of potassium ion transport (GO:0043267) | 3.17992127 |
88 | * lysine metabolic process (GO:0006553) | 3.16393546 |
89 | * lysine catabolic process (GO:0006554) | 3.16393546 |
90 | barbed-end actin filament capping (GO:0051016) | 3.15969630 |
91 | regulation of cardiac muscle contraction (GO:0055117) | 3.15847978 |
92 | striated muscle atrophy (GO:0014891) | 3.15562008 |
93 | regulation of heart rate (GO:0002027) | 3.15456556 |
94 | heart process (GO:0003015) | 3.14507799 |
95 | heart contraction (GO:0060047) | 3.14507799 |
96 | oxidative phosphorylation (GO:0006119) | 3.14383681 |
97 | branched-chain amino acid metabolic process (GO:0009081) | 3.13199007 |
98 | intracellular lipid transport (GO:0032365) | 3.13087655 |
99 | protein localization to endosome (GO:0036010) | 3.12628014 |
100 | cardiac conduction (GO:0061337) | 3.10137514 |
101 | cellular response to epinephrine stimulus (GO:0071872) | 3.09043674 |
102 | carnitine metabolic process (GO:0009437) | 3.08247348 |
103 | negative regulation of necroptotic process (GO:0060546) | 3.06225971 |
104 | cell-substrate junction assembly (GO:0007044) | 3.06059159 |
105 | monocarboxylic acid catabolic process (GO:0072329) | 3.04499850 |
106 | positive regulation of fatty acid beta-oxidation (GO:0032000) | 3.04401702 |
107 | regulation of heart rate by cardiac conduction (GO:0086091) | 3.03791273 |
108 | cardiac muscle adaptation (GO:0014887) | 3.02058273 |
109 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.02058273 |
110 | muscle hypertrophy in response to stress (GO:0003299) | 3.02058273 |
111 | positive regulation of myotube differentiation (GO:0010831) | 3.01718987 |
112 | COPI coating of Golgi vesicle (GO:0048205) | 3.00268430 |
113 | Golgi transport vesicle coating (GO:0048200) | 3.00268430 |
114 | striated muscle adaptation (GO:0014888) | 2.98291628 |
115 | muscle contraction (GO:0006936) | 2.97940878 |
116 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.95018500 |
117 | response to inactivity (GO:0014854) | 2.94391979 |
118 | regulation of heart contraction (GO:0008016) | 2.90627605 |
119 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 2.89132491 |
120 | glycogen catabolic process (GO:0005980) | 2.88670889 |
121 | negative regulation of cell size (GO:0045792) | 2.86226814 |
122 | glucan catabolic process (GO:0009251) | 2.85431567 |
123 | desmosome organization (GO:0002934) | 2.83168811 |
124 | fructose metabolic process (GO:0006000) | 2.80658980 |
125 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 2.78513660 |
126 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.78293849 |
127 | regulation of necroptotic process (GO:0060544) | 2.77774964 |
128 | gluconeogenesis (GO:0006094) | 2.76649582 |
129 | epithelial cell-cell adhesion (GO:0090136) | 2.76170937 |
130 | response to epinephrine (GO:0071871) | 2.72567060 |
131 | response to muscle activity (GO:0014850) | 2.69403318 |
132 | cellular polysaccharide catabolic process (GO:0044247) | 2.66758585 |
133 | muscle system process (GO:0003012) | 2.65423751 |
134 | pinocytosis (GO:0006907) | 2.62298644 |
135 | muscle atrophy (GO:0014889) | 2.61094576 |
136 | muscle adaptation (GO:0043500) | 2.59057439 |
137 | stress fiber assembly (GO:0043149) | 2.59048700 |
138 | sodium ion export (GO:0071436) | 2.59033173 |
139 | regulation of early endosome to late endosome transport (GO:2000641) | 2.56651777 |
140 | hexose biosynthetic process (GO:0019319) | 2.56635567 |
141 | negative regulation of myotube differentiation (GO:0010832) | 2.53830604 |
142 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.53691487 |
143 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 2.53218874 |
144 | regulation of glucose import in response to insulin stimulus (GO:2001273) | 2.53117338 |
145 | positive regulation of receptor recycling (GO:0001921) | 2.52162862 |
146 | response to mercury ion (GO:0046689) | 2.49060288 |
147 | monosaccharide biosynthetic process (GO:0046364) | 2.41324354 |
148 | activation of protein kinase A activity (GO:0034199) | 2.39132877 |
149 | polysaccharide catabolic process (GO:0000272) | 2.38891994 |
150 | regulation of necrotic cell death (GO:0010939) | 2.35658736 |
151 | protein targeting to plasma membrane (GO:0072661) | 2.35128080 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 7.38198783 |
2 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 3.89567790 |
3 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 3.79249476 |
4 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 3.43797946 |
5 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 3.13936008 |
6 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 2.95638011 |
7 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 2.85345482 |
8 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 2.85345482 |
9 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.75291962 |
10 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 2.65422995 |
11 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 2.65033299 |
12 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 2.49446829 |
13 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 2.45796154 |
14 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 2.38872350 |
15 | CLOCK_20551151_ChIP-Seq_293T_Human | 2.33693708 |
16 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.30587472 |
17 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.09397203 |
18 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.05312294 |
19 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.04786923 |
20 | TCF7_22412390_ChIP-Seq_EML_Mouse | 2.04650364 |
21 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 2.04033317 |
22 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.98272649 |
23 | MYC_22102868_ChIP-Seq_BL_Human | 1.95884459 |
24 | GATA1_22025678_ChIP-Seq_K562_Human | 1.91158046 |
25 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.86180117 |
26 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.73564931 |
27 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.68204373 |
28 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.65260502 |
29 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.60194299 |
30 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.58906347 |
31 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.54084505 |
32 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.52443080 |
33 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.49354106 |
34 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.45774230 |
35 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.43084609 |
36 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.38768698 |
37 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.37099304 |
38 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.36806721 |
39 | * TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.36802395 |
40 | GATA1_19941826_ChIP-Seq_K562_Human | 1.35259102 |
41 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.34596969 |
42 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.34222812 |
43 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.34104239 |
44 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.33462572 |
45 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.32572177 |
46 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.32404491 |
47 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.31467127 |
48 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.30299820 |
49 | MAF_26560356_Chip-Seq_TH1_Human | 1.29919393 |
50 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.29722541 |
51 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.29529288 |
52 | * NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.28936259 |
53 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.28813818 |
54 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.28248595 |
55 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 1.28149915 |
56 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.26812372 |
57 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.26175079 |
58 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.26154085 |
59 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.25370890 |
60 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.24245082 |
61 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.23141917 |
62 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.21191364 |
63 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.20484203 |
64 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.20106660 |
65 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.18119713 |
66 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.17460138 |
67 | P68_20966046_ChIP-Seq_HELA_Human | 1.16169706 |
68 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.15901772 |
69 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.14665253 |
70 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.14522676 |
71 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.14351100 |
72 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.13797496 |
73 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.13633729 |
74 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.12962451 |
75 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.12754155 |
76 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.11449082 |
77 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.11338082 |
78 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.11269957 |
79 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.11247502 |
80 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.11242501 |
81 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.11224389 |
82 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.11110801 |
83 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.10374563 |
84 | KDM2B_26808549_Chip-Seq_K562_Human | 1.10289677 |
85 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.10209199 |
86 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.09381799 |
87 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.09305315 |
88 | GATA2_19941826_ChIP-Seq_K562_Human | 1.09225295 |
89 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.09104101 |
90 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.08550252 |
91 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.08466264 |
92 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.06953725 |
93 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.05455358 |
94 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.05332631 |
95 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.05321408 |
96 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.05245167 |
97 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.04147035 |
98 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.04107098 |
99 | * PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.03674788 |
100 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.02897709 |
101 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.01729581 |
102 | * SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.00986290 |
103 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.00640596 |
104 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.00601201 |
105 | UTX_26944678_Chip-Seq_JUKART_Human | 1.00220933 |
106 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.00009940 |
107 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.99520740 |
108 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 0.99174901 |
109 | * ATF3_27146783_Chip-Seq_COLON_Human | 0.98281757 |
110 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 0.98082909 |
111 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.97857047 |
112 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.96987770 |
113 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.96975443 |
114 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.96196840 |
115 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.95646793 |
116 | * NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.95159035 |
117 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.94916451 |
118 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.92522868 |
119 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.92514816 |
120 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.91937624 |
121 | SPI1_23127762_ChIP-Seq_K562_Human | 0.91802017 |
122 | * SMC4_20622854_ChIP-Seq_HELA_Human | 0.91787269 |
123 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.91125674 |
124 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.89618179 |
125 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.89359330 |
126 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.88706675 |
127 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.88547783 |
128 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.87539637 |
129 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.87511318 |
130 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.87313107 |
131 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 0.86386280 |
132 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.86254291 |
133 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.83409656 |
134 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.82146332 |
135 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.81552395 |
136 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.81343294 |
137 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 0.80419108 |
138 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.80199059 |
139 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 0.80152062 |
140 | * BCL6_27268052_Chip-Seq_Bcells_Human | 0.79449084 |
141 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.77712984 |
142 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.76526905 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002837_dystrophic_cardiac_calcinosis | 6.45062890 |
2 | MP0003646_muscle_fatigue | 5.16462611 |
3 | MP0004084_abnormal_cardiac_muscle | 4.80847750 |
4 | MP0000751_myopathy | 4.57329369 |
5 | MP0004215_abnormal_myocardial_fiber | 4.02870774 |
6 | MP0005451_abnormal_body_composition | 4.00054757 |
7 | MP0004036_abnormal_muscle_relaxation | 3.75575238 |
8 | MP0005330_cardiomyopathy | 3.41939381 |
9 | MP0000749_muscle_degeneration | 3.26119851 |
10 | MP0004130_abnormal_muscle_cell | 3.14809329 |
11 | MP0004087_abnormal_muscle_fiber | 2.77383648 |
12 | MP0002972_abnormal_cardiac_muscle | 2.69911404 |
13 | MP0008775_abnormal_heart_ventricle | 2.57606388 |
14 | MP0005620_abnormal_muscle_contractility | 2.41524706 |
15 | MP0005670_abnormal_white_adipose | 2.40758195 |
16 | MP0003137_abnormal_impulse_conducting | 2.36480126 |
17 | MP0005385_cardiovascular_system_phenoty | 2.28644963 |
18 | MP0001544_abnormal_cardiovascular_syste | 2.28644963 |
19 | MP0000750_abnormal_muscle_regeneration | 2.23544530 |
20 | MP0005666_abnormal_adipose_tissue | 2.22868215 |
21 | MP0010630_abnormal_cardiac_muscle | 2.20697453 |
22 | MP0006138_congestive_heart_failure | 2.18989291 |
23 | MP0002269_muscular_atrophy | 2.15518507 |
24 | MP0002106_abnormal_muscle_physiology | 2.12856651 |
25 | MP0004484_altered_response_of | 2.07869507 |
26 | MP0010234_abnormal_vibrissa_follicle | 2.03605886 |
27 | MP0000747_muscle_weakness | 1.98798206 |
28 | MP0006036_abnormal_mitochondrial_physio | 1.96276243 |
29 | MP0004145_abnormal_muscle_electrophysio | 1.87523503 |
30 | MP0005058_abnormal_lysosome_morphology | 1.84781307 |
31 | MP0004085_abnormal_heartbeat | 1.84637858 |
32 | MP0004043_abnormal_pH_regulation | 1.81050642 |
33 | MP0003221_abnormal_cardiomyocyte_apopto | 1.76040491 |
34 | MP0000759_abnormal_skeletal_muscle | 1.74806158 |
35 | MP0005369_muscle_phenotype | 1.70050811 |
36 | MP0004233_abnormal_muscle_weight | 1.66934310 |
37 | MP0005375_adipose_tissue_phenotype | 1.63846997 |
38 | MP0003828_pulmonary_edema | 1.59391773 |
39 | MP0004185_abnormal_adipocyte_glucose | 1.57326130 |
40 | MP0005360_urolithiasis | 1.56282105 |
41 | MP0000733_abnormal_muscle_development | 1.56121658 |
42 | MP0004858_abnormal_nervous_system | 1.54220571 |
43 | MP0008260_abnormal_autophagy | 1.51917495 |
44 | MP0004510_myositis | 1.45651810 |
45 | MP0008961_abnormal_basal_metabolism | 1.40880369 |
46 | MP0000013_abnormal_adipose_tissue | 1.36061895 |
47 | MP0002909_abnormal_adrenal_gland | 1.33849251 |
48 | MP0005409_darkened_coat_color | 1.32779979 |
49 | MP0001849_ear_inflammation | 1.30482207 |
50 | MP0008438_abnormal_cutaneous_collagen | 1.29799123 |
51 | MP0003705_abnormal_hypodermis_morpholog | 1.29392089 |
52 | MP0002332_abnormal_exercise_endurance | 1.27934765 |
53 | MP0003091_abnormal_cell_migration | 1.27653665 |
54 | MP0000003_abnormal_adipose_tissue | 1.23849532 |
55 | MP0002971_abnormal_brown_adipose | 1.23599027 |
56 | MP0003453_abnormal_keratinocyte_physiol | 1.20505911 |
57 | MP0002796_impaired_skin_barrier | 1.12658778 |
58 | MP0009780_abnormal_chondrocyte_physiolo | 1.10566436 |
59 | MP0005332_abnormal_amino_acid | 1.09573936 |
60 | MP0004947_skin_inflammation | 1.08363251 |
61 | MP0002127_abnormal_cardiovascular_syste | 1.08041269 |
62 | MP0005085_abnormal_gallbladder_physiolo | 1.05521435 |
63 | MP0003303_peritoneal_inflammation | 1.05249563 |
64 | MP0009840_abnormal_foam_cell | 1.04522002 |
65 | MP0005535_abnormal_body_temperature | 1.04050072 |
66 | MP0005076_abnormal_cell_differentiation | 1.03457075 |
67 | MP0000230_abnormal_systemic_arterial | 1.02896472 |
68 | MP0010329_abnormal_lipoprotein_level | 1.00066355 |
69 | MP0002078_abnormal_glucose_homeostasis | 0.99975428 |
70 | MP0006035_abnormal_mitochondrial_morpho | 0.99492654 |
71 | MP0002118_abnormal_lipid_homeostasis | 0.98854242 |
72 | MP0003436_decreased_susceptibility_to | 0.98549071 |
73 | MP0002139_abnormal_hepatobiliary_system | 0.97298241 |
74 | MP0000343_altered_response_to | 0.96234340 |
75 | MP0001661_extended_life_span | 0.95240751 |
76 | MP0002234_abnormal_pharynx_morphology | 0.94939848 |
77 | MP0005165_increased_susceptibility_to | 0.94328285 |
78 | MP0003950_abnormal_plasma_membrane | 0.93492812 |
79 | MP0000266_abnormal_heart_morphology | 0.91848322 |
80 | MP0003075_altered_response_to | 0.91023535 |
81 | MP0005319_abnormal_enzyme/_coenzyme | 0.90594362 |
82 | MP0005365_abnormal_bile_salt | 0.88631733 |
83 | MP0005266_abnormal_metabolism | 0.88000505 |
84 | MP0003252_abnormal_bile_duct | 0.86949838 |
85 | MP0001958_emphysema | 0.86568620 |
86 | MP0003195_calcinosis | 0.85858913 |
87 | MP0010368_abnormal_lymphatic_system | 0.85852123 |
88 | MP0009643_abnormal_urine_homeostasis | 0.85268025 |
89 | MP0003879_abnormal_hair_cell | 0.83297749 |
90 | MP0004264_abnormal_extraembryonic_tissu | 0.82843077 |
91 | MP0005166_decreased_susceptibility_to | 0.81626642 |
92 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.81619065 |
93 | MP0003191_abnormal_cellular_cholesterol | 0.81208303 |
94 | MP0010352_gastrointestinal_tract_polyps | 0.80814509 |
95 | MP0004147_increased_porphyrin_level | 0.80033103 |
96 | MP0003566_abnormal_cell_adhesion | 0.79962021 |
97 | MP0002822_catalepsy | 0.78988809 |
98 | MP0008004_abnormal_stomach_pH | 0.77596034 |
99 | MP0003183_abnormal_peptide_metabolism | 0.77114694 |
100 | MP0003806_abnormal_nucleotide_metabolis | 0.76858424 |
101 | MP0003279_aneurysm | 0.75347774 |
102 | MP0001765_abnormal_ion_homeostasis | 0.74734626 |
103 | MP0005334_abnormal_fat_pad | 0.74254482 |
104 | MP0002896_abnormal_bone_mineralization | 0.73202006 |
105 | MP0002998_abnormal_bone_remodeling | 0.73029757 |
106 | MP0001348_abnormal_lacrimal_gland | 0.71703423 |
107 | MP0000858_altered_metastatic_potential | 0.70862707 |
108 | MP0003656_abnormal_erythrocyte_physiolo | 0.70362066 |
109 | MP0002060_abnormal_skin_morphology | 0.69876156 |
110 | MP0004272_abnormal_basement_membrane | 0.69446272 |
111 | MP0002108_abnormal_muscle_morphology | 0.68039507 |
112 | MP0000604_amyloidosis | 0.67661467 |
113 | MP0000678_abnormal_parathyroid_gland | 0.67438101 |
114 | MP0008874_decreased_physiological_sensi | 0.66524578 |
115 | MP0005023_abnormal_wound_healing | 0.66373752 |
116 | MP0003567_abnormal_fetal_cardiomyocyte | 0.66269952 |
117 | MP0001666_abnormal_nutrient_absorption | 0.65705704 |
118 | MP0009115_abnormal_fat_cell | 0.64578342 |
119 | MP0001756_abnormal_urination | 0.63864380 |
120 | MP0000767_abnormal_smooth_muscle | 0.62189693 |
121 | MP0005448_abnormal_energy_balance | 0.61816634 |
122 | MP0003763_abnormal_thymus_physiology | 0.61109573 |
123 | MP0005501_abnormal_skin_physiology | 0.60962042 |
124 | MP0002970_abnormal_white_adipose | 0.60561107 |
125 | MP0005167_abnormal_blood-brain_barrier | 0.60470928 |
126 | MP0000609_abnormal_liver_physiology | 0.60387247 |
127 | MP0003045_fibrosis | 0.58980062 |
128 | MP0002128_abnormal_blood_circulation | 0.58978602 |
129 | MP0003329_amyloid_beta_deposits | 0.58111906 |
130 | MP0009278_abnormal_bone_marrow | 0.56510934 |
131 | MP0005187_abnormal_penis_morphology | 0.56223640 |
132 | MP0005083_abnormal_biliary_tract | 0.55529143 |
133 | MP0008875_abnormal_xenobiotic_pharmacok | 0.53294649 |
134 | MP0001879_abnormal_lymphatic_vessel | 0.49559892 |
135 | MP0003300_gastrointestinal_ulcer | 0.49105859 |
136 | MP0003283_abnormal_digestive_organ | 0.48380419 |
137 | MP0003953_abnormal_hormone_level | 0.45461089 |
138 | MP0005452_abnormal_adipose_tissue | 0.44307980 |
139 | MP0005275_abnormal_skin_tensile | 0.43490639 |
140 | MP0002877_abnormal_melanocyte_morpholog | 0.43108498 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Sudden death (HP:0001699) | 6.68436170 |
2 | Ventricular tachycardia (HP:0004756) | 5.63976873 |
3 | Nemaline bodies (HP:0003798) | 5.56091156 |
4 | Exercise-induced myalgia (HP:0003738) | 5.51956934 |
5 | Myoglobinuria (HP:0002913) | 5.42996059 |
6 | Exercise-induced muscle cramps (HP:0003710) | 5.16462894 |
7 | Calf muscle hypertrophy (HP:0008981) | 4.99796026 |
8 | Muscle fiber splitting (HP:0003555) | 4.77961771 |
9 | Atrial fibrillation (HP:0005110) | 4.73823934 |
10 | Muscle hypertrophy of the lower extremities (HP:0008968) | 4.58838186 |
11 | Right ventricular cardiomyopathy (HP:0011663) | 4.53861389 |
12 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 4.51967442 |
13 | Primary atrial arrhythmia (HP:0001692) | 4.42693760 |
14 | Hyporeflexia of lower limbs (HP:0002600) | 4.40969600 |
15 | Supraventricular tachycardia (HP:0004755) | 4.25651589 |
16 | Lipoatrophy (HP:0100578) | 4.24782073 |
17 | Bundle branch block (HP:0011710) | 4.19409107 |
18 | Supraventricular arrhythmia (HP:0005115) | 4.18570797 |
19 | Syncope (HP:0001279) | 4.07952090 |
20 | Abnormality of the calf musculature (HP:0001430) | 4.07177642 |
21 | Palpitations (HP:0001962) | 4.07100569 |
22 | Rhabdomyolysis (HP:0003201) | 4.00232077 |
23 | Subaortic stenosis (HP:0001682) | 3.96222248 |
24 | Abnormality of the left ventricular outflow tract (HP:0011103) | 3.96222248 |
25 | Ketoacidosis (HP:0001993) | 3.89804012 |
26 | Myopathic facies (HP:0002058) | 3.84248187 |
27 | Distal lower limb amyotrophy (HP:0008944) | 3.78452121 |
28 | Hypoglycemic coma (HP:0001325) | 3.75646058 |
29 | Difficulty running (HP:0009046) | 3.74726427 |
30 | Dilated cardiomyopathy (HP:0001644) | 3.73174845 |
31 | Increased connective tissue (HP:0009025) | 3.70254711 |
32 | Asymmetric septal hypertrophy (HP:0001670) | 3.69077932 |
33 | Prolonged QT interval (HP:0001657) | 3.63894413 |
34 | Ventricular arrhythmia (HP:0004308) | 3.50201567 |
35 | Ventricular fibrillation (HP:0001663) | 3.46039280 |
36 | EMG: myopathic abnormalities (HP:0003458) | 3.40480659 |
37 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.38812956 |
38 | Heart block (HP:0012722) | 3.38773989 |
39 | Atrioventricular block (HP:0001678) | 3.37606559 |
40 | Abnormal atrioventricular conduction (HP:0005150) | 3.16544588 |
41 | Ketosis (HP:0001946) | 3.10930627 |
42 | Myotonia (HP:0002486) | 3.02843829 |
43 | Hyperglycinuria (HP:0003108) | 3.01847669 |
44 | Dicarboxylic aciduria (HP:0003215) | 2.96922200 |
45 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.96922200 |
46 | Lower limb amyotrophy (HP:0007210) | 2.78468491 |
47 | Hepatic necrosis (HP:0002605) | 2.76842473 |
48 | Round ear (HP:0100830) | 2.74712566 |
49 | Muscle stiffness (HP:0003552) | 2.69849372 |
50 | Ulnar deviation of the wrist (HP:0003049) | 2.68256691 |
51 | Difficulty climbing stairs (HP:0003551) | 2.67923037 |
52 | Abnormal EKG (HP:0003115) | 2.66410528 |
53 | Increased muscle lipid content (HP:0009058) | 2.63231268 |
54 | Bulbar palsy (HP:0001283) | 2.59245325 |
55 | Conjunctival hamartoma (HP:0100780) | 2.58542807 |
56 | Hyperammonemia (HP:0001987) | 2.54258714 |
57 | Distal arthrogryposis (HP:0005684) | 2.51918544 |
58 | Generalized aminoaciduria (HP:0002909) | 2.49293721 |
59 | Increased variability in muscle fiber diameter (HP:0003557) | 2.48943490 |
60 | Pheochromocytoma (HP:0002666) | 2.47997972 |
61 | Dysmetric saccades (HP:0000641) | 2.46731403 |
62 | Foot dorsiflexor weakness (HP:0009027) | 2.46608526 |
63 | Abnormality of glycine metabolism (HP:0010895) | 2.44516774 |
64 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.44516774 |
65 | Hyperinsulinemic hypoglycemia (HP:0000825) | 2.43367728 |
66 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.42896562 |
67 | Abnormality of the foot musculature (HP:0001436) | 2.41782484 |
68 | Spinal rigidity (HP:0003306) | 2.40598195 |
69 | Frequent falls (HP:0002359) | 2.31912389 |
70 | Hamartoma of the eye (HP:0010568) | 2.30123231 |
71 | Rimmed vacuoles (HP:0003805) | 2.29932323 |
72 | Left ventricular hypertrophy (HP:0001712) | 2.29405699 |
73 | Scapular winging (HP:0003691) | 2.29253085 |
74 | Ragged-red muscle fibers (HP:0003200) | 2.29166275 |
75 | Achilles tendon contracture (HP:0001771) | 2.27664219 |
76 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.26324349 |
77 | Type 1 muscle fiber predominance (HP:0003803) | 2.25297839 |
78 | Limb-girdle muscle atrophy (HP:0003797) | 2.21664945 |
79 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.17964828 |
80 | Gout (HP:0001997) | 2.12254042 |
81 | Neuroendocrine neoplasm (HP:0100634) | 2.10882619 |
82 | Facial diplegia (HP:0001349) | 2.10657256 |
83 | Cerebral aneurysm (HP:0004944) | 2.09107589 |
84 | Cerebral edema (HP:0002181) | 2.06012961 |
85 | Palmoplantar keratoderma (HP:0000982) | 2.05661581 |
86 | Hepatocellular necrosis (HP:0001404) | 2.04681338 |
87 | Lymphangioma (HP:0100764) | 2.03408563 |
88 | Abnormality of the Achilles tendon (HP:0005109) | 2.02469074 |
89 | Acute encephalopathy (HP:0006846) | 2.01102751 |
90 | Distal lower limb muscle weakness (HP:0009053) | 2.01029170 |
91 | Testicular atrophy (HP:0000029) | 1.99646060 |
92 | Neck muscle weakness (HP:0000467) | 1.98706462 |
93 | Athetosis (HP:0002305) | 1.97280078 |
94 | Progressive muscle weakness (HP:0003323) | 1.96927059 |
95 | Neoplasm of the adrenal gland (HP:0100631) | 1.96887498 |
96 | Large for gestational age (HP:0001520) | 1.96301711 |
97 | Proximal tubulopathy (HP:0000114) | 1.96118427 |
98 | Sudden cardiac death (HP:0001645) | 1.95665861 |
99 | Muscle fiber inclusion bodies (HP:0100299) | 1.95224642 |
100 | Cholelithiasis (HP:0001081) | 1.90755841 |
101 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.90255389 |
102 | Increased intramyocellular lipid droplets (HP:0012240) | 1.89963999 |
103 | Central scotoma (HP:0000603) | 1.88954314 |
104 | Upper limb amyotrophy (HP:0009129) | 1.88655300 |
105 | Distal upper limb amyotrophy (HP:0007149) | 1.88655300 |
106 | Hyperacusis (HP:0010780) | 1.87852095 |
107 | EMG: neuropathic changes (HP:0003445) | 1.86884910 |
108 | Generalized muscle weakness (HP:0003324) | 1.86464904 |
109 | Hyperglycemia (HP:0003074) | 1.86208302 |
110 | Esophageal neoplasm (HP:0100751) | 1.86126928 |
111 | Neoplasm of head and neck (HP:0012288) | 1.86126928 |
112 | Acute necrotizing encephalopathy (HP:0006965) | 1.84612204 |
113 | Areflexia of lower limbs (HP:0002522) | 1.83761134 |
114 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.83434225 |
115 | Vertebral compression fractures (HP:0002953) | 1.82837741 |
116 | Congestive heart failure (HP:0001635) | 1.80421313 |
117 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.79310670 |
118 | Osteolytic defects of the hand bones (HP:0009699) | 1.79310670 |
119 | Late onset (HP:0003584) | 1.76777852 |
120 | Insulin-resistant diabetes mellitus (HP:0000831) | 1.76521542 |
121 | Nausea (HP:0002018) | 1.75588909 |
122 | Axonal loss (HP:0003447) | 1.75270235 |
123 | * Lactic acidosis (HP:0003128) | 1.73652256 |
124 | Tinnitus (HP:0000360) | 1.73412325 |
125 | Protrusio acetabuli (HP:0003179) | 1.72864380 |
126 | Neonatal death (HP:0003811) | 1.72744827 |
127 | * Metabolic acidosis (HP:0001942) | 1.72726667 |
128 | Slender build (HP:0001533) | 1.70839104 |
129 | Obstructive sleep apnea (HP:0002870) | 1.69588374 |
130 | Aneurysm (HP:0002617) | 1.69012574 |
131 | Calcaneovalgus deformity (HP:0001848) | 1.68237053 |
132 | Generalized amyotrophy (HP:0003700) | 1.62807352 |
133 | Gowers sign (HP:0003391) | 1.62229636 |
134 | Broad face (HP:0000283) | 1.60200939 |
135 | Eczematoid dermatitis (HP:0000976) | 1.58864152 |
136 | Back pain (HP:0003418) | 1.58820354 |
137 | Cerebral inclusion bodies (HP:0100314) | 1.56317986 |
138 | Easy fatigability (HP:0003388) | 1.55736410 |
139 | Fatigue (HP:0012378) | 1.54022806 |
140 | Flat acetabular roof (HP:0003180) | 1.53919205 |
141 | Muscular dystrophy (HP:0003560) | 1.51053565 |
142 | Malignant hyperthermia (HP:0002047) | 1.50081723 |
143 | Premature rupture of membranes (HP:0001788) | 1.49561771 |
144 | Thin bony cortex (HP:0002753) | 1.48425643 |
145 | Abnormality of the tricuspid valve (HP:0001702) | 1.47878998 |
146 | Hemorrhage of the eye (HP:0011885) | 1.47106710 |
147 | Diaphragmatic weakness (HP:0009113) | 1.45807087 |
148 | Abnormality of the calcaneus (HP:0008364) | 1.45646728 |
149 | Rapidly progressive (HP:0003678) | 1.45109898 |
150 | Hyperkalemia (HP:0002153) | 1.43589168 |
151 | Advanced eruption of teeth (HP:0006288) | 1.41844220 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TTN | 4.85452618 |
2 | LMTK2 | 4.04270909 |
3 | TRIB3 | 3.90210467 |
4 | PDK4 | 3.58622443 |
5 | PDK3 | 3.58622443 |
6 | PHKG1 | 3.43085164 |
7 | PHKG2 | 3.43085164 |
8 | BCKDK | 3.32214787 |
9 | PKN2 | 3.08488215 |
10 | OBSCN | 3.02150346 |
11 | PRPF4B | 2.92823324 |
12 | MYLK | 2.67907527 |
13 | NEK1 | 2.42618412 |
14 | PDK2 | 2.28852892 |
15 | DMPK | 2.28058330 |
16 | SMG1 | 2.22098134 |
17 | WNK4 | 1.87281586 |
18 | PINK1 | 1.74795760 |
19 | TIE1 | 1.67744732 |
20 | EPHA2 | 1.63312097 |
21 | IRAK3 | 1.55691328 |
22 | RIPK1 | 1.50149827 |
23 | PIK3CA | 1.45437275 |
24 | CDK12 | 1.34957678 |
25 | TESK1 | 1.34716338 |
26 | INSRR | 1.31660618 |
27 | PAK3 | 1.30032016 |
28 | MAP3K7 | 1.29981122 |
29 | MAP3K13 | 1.24924099 |
30 | STK24 | 1.19755234 |
31 | ERN1 | 1.14850408 |
32 | PRKD1 | 1.14269162 |
33 | SIK1 | 1.13476635 |
34 | TAOK2 | 1.10884333 |
35 | TESK2 | 1.09386812 |
36 | PDGFRA | 1.06938310 |
37 | PRKD3 | 1.03974779 |
38 | PRKAA1 | 1.03886996 |
39 | LATS2 | 1.03511121 |
40 | CAMK1D | 1.03017009 |
41 | ARAF | 1.02024332 |
42 | PRKAA2 | 1.01196251 |
43 | MUSK | 0.99948082 |
44 | TBK1 | 0.96025713 |
45 | PTK6 | 0.93904021 |
46 | SCYL2 | 0.91599524 |
47 | CAMK2D | 0.90546858 |
48 | STK38 | 0.90502417 |
49 | ZAP70 | 0.88398112 |
50 | CDC42BPA | 0.86806381 |
51 | LIMK1 | 0.83401697 |
52 | FGFR4 | 0.83378291 |
53 | ILK | 0.82639972 |
54 | CAMK1G | 0.81658083 |
55 | MAP2K3 | 0.81318282 |
56 | PRKCH | 0.81162819 |
57 | WNK1 | 0.80682294 |
58 | MAP3K6 | 0.80659934 |
59 | MARK2 | 0.80611538 |
60 | MOS | 0.80043433 |
61 | PDPK1 | 0.79404838 |
62 | MAPK12 | 0.79324376 |
63 | MAPKAPK3 | 0.78380838 |
64 | MAP3K11 | 0.78079138 |
65 | ROCK1 | 0.76286318 |
66 | FLT3 | 0.75462437 |
67 | RIPK4 | 0.75117800 |
68 | EPHB1 | 0.74858789 |
69 | GRK7 | 0.73778247 |
70 | PIK3CG | 0.72963033 |
71 | PAK4 | 0.72536198 |
72 | PDK1 | 0.67343610 |
73 | TYK2 | 0.67025488 |
74 | CAMK4 | 0.65622550 |
75 | PRKD2 | 0.65311652 |
76 | PTK2 | 0.65235657 |
77 | RET | 0.64836737 |
78 | MET | 0.64376138 |
79 | SGK3 | 0.64288201 |
80 | TGFBR2 | 0.64060728 |
81 | KSR2 | 0.61025573 |
82 | MAP3K5 | 0.59050158 |
83 | ICK | 0.57977232 |
84 | MAP4K1 | 0.57792260 |
85 | MAPK4 | 0.56927378 |
86 | TAOK1 | 0.56783024 |
87 | PRKACG | 0.55554906 |
88 | MAP3K14 | 0.54976017 |
89 | MAP3K3 | 0.54933102 |
90 | JAK1 | 0.54807739 |
91 | MAPK7 | 0.52517691 |
92 | MAP2K2 | 0.49605862 |
93 | CAMK1 | 0.48389422 |
94 | PAK6 | 0.48130311 |
95 | MAP2K4 | 0.46874087 |
96 | BLK | 0.46519509 |
97 | MAP3K10 | 0.46074677 |
98 | LRRK2 | 0.46070558 |
99 | NEK9 | 0.45542711 |
100 | EPHA3 | 0.44832642 |
101 | DAPK3 | 0.44758969 |
102 | FER | 0.43722815 |
103 | KDR | 0.43226450 |
104 | PRKG2 | 0.42661203 |
105 | MAP3K1 | 0.42438949 |
106 | PTK2B | 0.41514589 |
107 | MAP3K8 | 0.41224693 |
108 | STK38L | 0.40556722 |
109 | PRKACB | 0.40396904 |
110 | NTRK1 | 0.40207185 |
111 | JAK2 | 0.39852928 |
112 | NME2 | 0.39511859 |
113 | CAMKK1 | 0.38875266 |
114 | MAPK11 | 0.38736693 |
115 | JAK3 | 0.38126131 |
116 | HIPK2 | 0.37930397 |
117 | STK39 | 0.37450251 |
118 | MTOR | 0.37322048 |
119 | ROCK2 | 0.37283161 |
120 | EEF2K | 0.36726663 |
121 | RPS6KL1 | 0.35690349 |
122 | RPS6KC1 | 0.35690349 |
123 | MAP3K9 | 0.35553308 |
124 | DYRK1B | 0.34654767 |
125 | STK4 | 0.34381938 |
126 | CAMK2A | 0.34098592 |
127 | WNK3 | 0.33609108 |
128 | PRKACA | 0.33285280 |
129 | CAMK2G | 0.31582649 |
130 | FGFR3 | 0.31373427 |
131 | MAP2K1 | 0.30351290 |
132 | AKT2 | 0.29720851 |
133 | RPS6KA6 | 0.28890703 |
134 | PRKCE | 0.28074417 |
135 | TRPM7 | 0.27632466 |
136 | RPS6KA2 | 0.27616641 |
137 | PKN1 | 0.27084767 |
138 | MST1R | 0.26658696 |
139 | SGK223 | 0.26549166 |
140 | SGK494 | 0.26549166 |
Rank | Gene Set | Z-score |
---|---|---|
1 | * Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 5.50857688 |
2 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 4.33100457 |
3 | Propanoate metabolism_Homo sapiens_hsa00640 | 3.60505182 |
4 | Fatty acid degradation_Homo sapiens_hsa00071 | 3.35182230 |
5 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.10608999 |
6 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.85404287 |
7 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.74279701 |
8 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.58822889 |
9 | * Carbon metabolism_Homo sapiens_hsa01200 | 2.41654406 |
10 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 2.37443761 |
11 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 2.22859289 |
12 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.16825577 |
13 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.10087112 |
14 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.97058027 |
15 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.85063656 |
16 | Other glycan degradation_Homo sapiens_hsa00511 | 1.66156924 |
17 | Parkinsons disease_Homo sapiens_hsa05012 | 1.61733333 |
18 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.54624474 |
19 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.47590201 |
20 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.36020618 |
21 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.35526097 |
22 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.31523464 |
23 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.27496647 |
24 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.25975920 |
25 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.25261451 |
26 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.23348959 |
27 | Alzheimers disease_Homo sapiens_hsa05010 | 1.21400218 |
28 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.21321567 |
29 | Insulin resistance_Homo sapiens_hsa04931 | 1.20938536 |
30 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.20565366 |
31 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.19215975 |
32 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.17654571 |
33 | Prion diseases_Homo sapiens_hsa05020 | 1.16645346 |
34 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.16074557 |
35 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.14859595 |
36 | * Tryptophan metabolism_Homo sapiens_hsa00380 | 1.14622170 |
37 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.12943948 |
38 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.11610884 |
39 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.11542292 |
40 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.08709451 |
41 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.02701901 |
42 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.01609666 |
43 | Endometrial cancer_Homo sapiens_hsa05213 | 1.00013115 |
44 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.97749532 |
45 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.96614930 |
46 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.94632172 |
47 | Peroxisome_Homo sapiens_hsa04146 | 0.94517849 |
48 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.92713228 |
49 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.90531765 |
50 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.89368252 |
51 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.88210133 |
52 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.88099264 |
53 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.87688932 |
54 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.87668095 |
55 | Bile secretion_Homo sapiens_hsa04976 | 0.86944938 |
56 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.86341311 |
57 | Viral myocarditis_Homo sapiens_hsa05416 | 0.85605320 |
58 | Bladder cancer_Homo sapiens_hsa05219 | 0.85522019 |
59 | Long-term potentiation_Homo sapiens_hsa04720 | 0.83884944 |
60 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.82446033 |
61 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.82037969 |
62 | Thyroid cancer_Homo sapiens_hsa05216 | 0.81486645 |
63 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.80604898 |
64 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.80099842 |
65 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.79517024 |
66 | Galactose metabolism_Homo sapiens_hsa00052 | 0.79374207 |
67 | Adherens junction_Homo sapiens_hsa04520 | 0.79366311 |
68 | Huntingtons disease_Homo sapiens_hsa05016 | 0.79096847 |
69 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.78555697 |
70 | * Lysine degradation_Homo sapiens_hsa00310 | 0.76746069 |
71 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.75262292 |
72 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.75213975 |
73 | Glioma_Homo sapiens_hsa05214 | 0.74931659 |
74 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.74631048 |
75 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.73728362 |
76 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.73149431 |
77 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.70405380 |
78 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.68478152 |
79 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.67627825 |
80 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.66914302 |
81 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.66770301 |
82 | Hepatitis C_Homo sapiens_hsa05160 | 0.66296592 |
83 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.65506105 |
84 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.65254396 |
85 | Insulin secretion_Homo sapiens_hsa04911 | 0.65189556 |
86 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.64651736 |
87 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.64565951 |
88 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.61530568 |
89 | Renin secretion_Homo sapiens_hsa04924 | 0.61458032 |
90 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.60533526 |
91 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.59829367 |
92 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.59738791 |
93 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.59191568 |
94 | Lysosome_Homo sapiens_hsa04142 | 0.59024100 |
95 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.58997638 |
96 | Platelet activation_Homo sapiens_hsa04611 | 0.57686582 |
97 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.54950876 |
98 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.54325860 |
99 | Endocytosis_Homo sapiens_hsa04144 | 0.54049330 |
100 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.53036237 |
101 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.52167913 |
102 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.50643270 |
103 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.50382618 |
104 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.49450367 |
105 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.48415556 |
106 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.47866635 |
107 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.47711950 |
108 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.47309383 |
109 | Leishmaniasis_Homo sapiens_hsa05140 | 0.46435839 |
110 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.46007375 |
111 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.45939899 |
112 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.45432228 |
113 | ABC transporters_Homo sapiens_hsa02010 | 0.45163194 |
114 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.44213549 |
115 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.44128360 |
116 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.42585534 |
117 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.42502675 |
118 | Focal adhesion_Homo sapiens_hsa04510 | 0.42036355 |
119 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.41528216 |
120 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.37496217 |
121 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.34021056 |
122 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.33735443 |
123 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.31728747 |
124 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.31127597 |
125 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.30790371 |
126 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.28812383 |
127 | Circadian entrainment_Homo sapiens_hsa04713 | 0.27490199 |
128 | Tight junction_Homo sapiens_hsa04530 | 0.27175265 |
129 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.26948625 |
130 | Salivary secretion_Homo sapiens_hsa04970 | 0.26825938 |
131 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.25816925 |
132 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.25080541 |
133 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.24539374 |
134 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.21728330 |
135 | Circadian rhythm_Homo sapiens_hsa04710 | 0.20567958 |
136 | Amoebiasis_Homo sapiens_hsa05146 | 0.19764907 |
137 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.18063912 |
138 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.17152955 |
139 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.16337636 |
140 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.15805191 |
141 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.15524569 |
142 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.15415611 |
143 | Gap junction_Homo sapiens_hsa04540 | 0.14301103 |
144 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.13910456 |
145 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.12629758 |