OGDHL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the AKT signaling cascade and can suppress the growth of cervical cancer cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.03238063
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.03238063
3exogenous drug catabolic process (GO:0042738)6.02248121
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.56805433
5L-phenylalanine metabolic process (GO:0006558)5.56805433
6drug catabolic process (GO:0042737)5.42328719
7epoxygenase P450 pathway (GO:0019373)5.37555209
8omega-hydroxylase P450 pathway (GO:0097267)5.36356174
9synaptic vesicle maturation (GO:0016188)5.31340163
10regulation of fibrinolysis (GO:0051917)5.29862516
11glyoxylate metabolic process (GO:0046487)5.08575134
12regulation of short-term neuronal synaptic plasticity (GO:0048172)5.00376984
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.98012340
14negative regulation of fibrinolysis (GO:0051918)4.88773315
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.74841346
16cell communication by electrical coupling (GO:0010644)4.64313659
17locomotory exploration behavior (GO:0035641)4.50593687
18complement activation, alternative pathway (GO:0006957)4.47218172
19regulation of protein activation cascade (GO:2000257)4.27341204
20urea metabolic process (GO:0019627)4.25483553
21ethanol oxidation (GO:0006069)4.12510126
22negative regulation of potassium ion transmembrane transport (GO:1901380)4.09767857
23regulation of complement activation (GO:0030449)4.01890544
24protein carboxylation (GO:0018214)3.98976985
25peptidyl-glutamic acid carboxylation (GO:0017187)3.98976985
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.97589340
27negative regulation of cholesterol transport (GO:0032375)3.95986350
28negative regulation of sterol transport (GO:0032372)3.95986350
29nitrogen cycle metabolic process (GO:0071941)3.94923890
30serine family amino acid catabolic process (GO:0009071)3.92025285
31sodium ion export (GO:0071436)3.91927126
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.87382075
33regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.87062036
34fibrinolysis (GO:0042730)3.84399022
35regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.80795192
36cerebellar granule cell differentiation (GO:0021707)3.80165070
37aromatic amino acid family catabolic process (GO:0009074)3.79990890
38cell communication involved in cardiac conduction (GO:0086065)3.77458865
39synaptic vesicle exocytosis (GO:0016079)3.74360256
40plasma membrane repair (GO:0001778)3.71903750
41negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.71218311
42positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.71101663
43regulation of synapse structural plasticity (GO:0051823)3.70740751
44glutamate secretion (GO:0014047)3.69909009
45glutamate metabolic process (GO:0006536)3.69677431
46layer formation in cerebral cortex (GO:0021819)3.68903007
47regulation of synaptic vesicle exocytosis (GO:2000300)3.66269696
48drug metabolic process (GO:0017144)3.63922605
49blood coagulation, intrinsic pathway (GO:0007597)3.61251073
50urea cycle (GO:0000050)3.61110656
51regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.59135419
52cellular glucuronidation (GO:0052695)3.54223816
53negative regulation of cytosolic calcium ion concentration (GO:0051481)3.47977052
54response to mercury ion (GO:0046689)3.47842777
55activation of protein kinase A activity (GO:0034199)3.46183765
56oxidative demethylation (GO:0070989)3.46146523
57cellular potassium ion homeostasis (GO:0030007)3.43803805
58cardiac myofibril assembly (GO:0055003)3.42135366
59regulation of membrane repolarization (GO:0060306)3.41135572
60vocalization behavior (GO:0071625)3.40205847
61neuromuscular process controlling posture (GO:0050884)3.37843297
62potassium ion import (GO:0010107)3.37639048
63neurotransmitter secretion (GO:0007269)3.35026463
64bile acid biosynthetic process (GO:0006699)3.32131677
65triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.30626070
66cardiac muscle contraction (GO:0060048)3.29525038
67uronic acid metabolic process (GO:0006063)3.28227929
68glucuronate metabolic process (GO:0019585)3.28227929
69regulation of synaptic vesicle transport (GO:1902803)3.26435661
70regulation of neurotransmitter levels (GO:0001505)3.25302426
71cerebellar Purkinje cell layer development (GO:0021680)3.25061985
72regulation of plasminogen activation (GO:0010755)3.24709337
73regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.23763237
74L-amino acid import (GO:0043092)3.23740017
75proline transport (GO:0015824)3.23260131
76dicarboxylic acid biosynthetic process (GO:0043650)3.22087828
77regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.20917611
78regulation of glutamate receptor signaling pathway (GO:1900449)3.20869572
79neuromuscular process controlling balance (GO:0050885)3.18905027
80dendritic spine morphogenesis (GO:0060997)3.18396614
81amino acid import (GO:0043090)3.18190437
82regulation of neuronal synaptic plasticity (GO:0048168)3.17952651
83glycine metabolic process (GO:0006544)3.16032647
84regulation of female receptivity (GO:0045924)3.14411921
85positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.13499754
86cytoskeletal anchoring at plasma membrane (GO:0007016)3.12329434
87phenylpropanoid metabolic process (GO:0009698)3.11655992
88regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.11556252
89ethanol metabolic process (GO:0006067)3.10678180
90negative regulation of synaptic transmission, GABAergic (GO:0032229)3.08383558
91S-adenosylmethionine metabolic process (GO:0046500)3.05961420
92regulation of long-term neuronal synaptic plasticity (GO:0048169)3.05150352
93cellular sodium ion homeostasis (GO:0006883)3.04652636
94bile acid metabolic process (GO:0008206)3.03778781
95amino-acid betaine metabolic process (GO:0006577)3.02923906
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02452847
97neurotransmitter-gated ion channel clustering (GO:0072578)3.01361385
98exploration behavior (GO:0035640)3.00888746
99neuronal action potential propagation (GO:0019227)3.00675420
100detection of calcium ion (GO:0005513)3.00484243
101negative regulation of dendrite morphogenesis (GO:0050774)2.99058481
102regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98422527
103cell migration in hindbrain (GO:0021535)2.97313575
104sarcomere organization (GO:0045214)2.95863667
105positive regulation of synapse maturation (GO:0090129)2.94993220
106membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.93705698
107positive regulation of potassium ion transmembrane transport (GO:1901381)2.92946343
108membrane repolarization (GO:0086009)2.92301105
109positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90109627
110vesicle transport along microtubule (GO:0047496)2.89308855
111glycine transport (GO:0015816)2.89148611
112phosphate ion transmembrane transport (GO:0035435)2.88504363
113regulation of calcium ion transmembrane transport (GO:1903169)2.86467767
114regulation of calcium ion transmembrane transporter activity (GO:1901019)2.86467767
115female mating behavior (GO:0060180)2.85618977
116oxaloacetate metabolic process (GO:0006107)2.85484840
117acylglycerol homeostasis (GO:0055090)2.85191233
118triglyceride homeostasis (GO:0070328)2.85191233
119growth hormone secretion (GO:0030252)2.85081101
120neuronal ion channel clustering (GO:0045161)2.83509810
121alpha-amino acid catabolic process (GO:1901606)2.82684040
122iron coordination entity transport (GO:1901678)2.81375435
123negative regulation of organelle assembly (GO:1902116)2.80428878
124potassium ion homeostasis (GO:0055075)2.80397945
125neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.78906945
126regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.78663227
127imidazole-containing compound metabolic process (GO:0052803)2.77177591
128membrane depolarization during action potential (GO:0086010)2.76691405
129ventricular cardiac muscle cell action potential (GO:0086005)2.76527523
130positive regulation of neurotransmitter secretion (GO:0001956)2.76150385
131cerebellar Purkinje cell differentiation (GO:0021702)2.75345185
132pre-miRNA processing (GO:0031054)2.73776796
133regulation of synapse maturation (GO:0090128)2.73773184
134positive regulation of membrane potential (GO:0045838)2.73600795
135negative regulation of potassium ion transport (GO:0043267)2.72374373
136establishment of nucleus localization (GO:0040023)2.71413024
137positive regulation of neurotransmitter transport (GO:0051590)2.70655505
138positive regulation of dendritic spine development (GO:0060999)2.70404657
139regulation of synaptic plasticity (GO:0048167)2.70376407
140cardiac conduction (GO:0061337)2.69895971
141gamma-aminobutyric acid transport (GO:0015812)2.69745214
142tyrosine metabolic process (GO:0006570)2.69380548
143long-term memory (GO:0007616)2.68241205
144negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.67431666
145positive regulation of potassium ion transport (GO:0043268)2.67107892
146positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.66170134
147synaptic transmission, glutamatergic (GO:0035249)2.63995177
148membrane repolarization during action potential (GO:0086011)2.63694882
149organelle transport along microtubule (GO:0072384)2.63429523
150striatum development (GO:0021756)2.61692637
151synaptic vesicle endocytosis (GO:0048488)2.61336854
152ionotropic glutamate receptor signaling pathway (GO:0035235)2.60547228
153regulation of potassium ion transmembrane transport (GO:1901379)2.60105989
154protein localization to synapse (GO:0035418)2.59200488
155neurotransmitter transport (GO:0006836)2.59180567
156cardiac muscle cell action potential involved in contraction (GO:0086002)2.58097313
157myofibril assembly (GO:0030239)2.57508071
158cardiac muscle cell action potential (GO:0086001)2.56922718
159innervation (GO:0060384)2.56488892
160regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55775572
161regulation of heart rate by cardiac conduction (GO:0086091)2.55016216
162chemosensory behavior (GO:0007635)2.54912703
163dendritic spine organization (GO:0097061)2.54282412
164relaxation of cardiac muscle (GO:0055119)2.53177973
165auditory behavior (GO:0031223)2.51424863
166regulation of ARF protein signal transduction (GO:0032012)2.48830669
167regulation of dendritic spine morphogenesis (GO:0061001)2.47797716
168neuron-neuron synaptic transmission (GO:0007270)2.47242305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.03142955
2EZH2_22144423_ChIP-Seq_EOC_Human4.36324481
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.20296426
4SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.09001388
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.98378283
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.97177698
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.80363765
8ZFP281_18757296_ChIP-ChIP_E14_Mouse2.67897405
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.55021978
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.52726832
11DROSHA_22980978_ChIP-Seq_HELA_Human2.41237687
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.37323239
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.27217009
14* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.23220511
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.21667560
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.16733834
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.05335706
18* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.02813681
19SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.02137177
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01293255
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00973018
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98835442
23ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.95617357
24ERG_21242973_ChIP-ChIP_JURKAT_Human1.94508172
25KDM2B_26808549_Chip-Seq_K562_Human1.88615193
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85960492
27* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.83581323
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.82798069
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.79210403
30* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.74962017
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73579256
32NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.72801229
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71424829
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.70185459
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67871600
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67871600
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.66917509
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.64085767
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.63822190
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61917620
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.61850855
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.59453128
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58554492
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.57233906
45ZNF263_19887448_ChIP-Seq_K562_Human1.56410809
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51634036
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50602754
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50124139
49SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.50026693
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49897577
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49159043
52NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.48071244
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46466315
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.45718921
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45572027
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44425879
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44425879
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44425879
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44190973
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44041601
61KDM2B_26808549_Chip-Seq_DND41_Human1.40100965
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.39316276
63FOXA2_19822575_ChIP-Seq_HepG2_Human1.37919991
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.36813602
65POU5F1_16518401_ChIP-PET_MESCs_Mouse1.35299664
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.35054544
67LXR_22292898_ChIP-Seq_THP-1_Human1.34349084
68TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32937393
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31460117
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29874818
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29682257
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21767854
73AR_19668381_ChIP-Seq_PC3_Human1.20057239
74* CTCF_27219007_Chip-Seq_Bcells_Human1.19478094
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18773495
76CREB1_26743006_Chip-Seq_LNCaP_Human1.18431470
77CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18124765
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17053588
79TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17035825
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.16555405
81TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.16079427
82SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14452210
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14400276
84TET1_21490601_ChIP-Seq_MESCs_Mouse1.14177493
85* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.13923501
86SMC4_20622854_ChIP-Seq_HELA_Human1.13615039
87OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13539356
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12739049
89ZNF274_21170338_ChIP-Seq_K562_Hela1.11815398
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.10616426
91TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08731949
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07325433
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07215923
94TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06621773
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.06401855
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06112353
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.06105988
98SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05982428
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05308804
100SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04948870
101TP53_23651856_ChIP-Seq_MEFs_Mouse1.04927881
102POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04179786
103OCT4_19829295_ChIP-Seq_ESCs_Human1.02306220
104P68_20966046_ChIP-Seq_HELA_Human1.02002794
105HTT_18923047_ChIP-ChIP_STHdh_Human1.01339248
106* SOX2_21211035_ChIP-Seq_LN229_Gbm1.00650843
107TBX20_22080862_ChIP-Seq_HEART_Mouse0.99224168
108TBX20_22328084_ChIP-Seq_HEART_Mouse0.99224168
109GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.97960938
110STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97848250
111ESR2_21235772_ChIP-Seq_MCF-7_Human0.97169977
112YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96468818
113NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96409249
114TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96083018
115TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.95847499
116NANOG_21062744_ChIP-ChIP_HESCs_Human0.95589073
117KLF4_19829295_ChIP-Seq_ESCs_Human0.94407320
118GBX2_23144817_ChIP-Seq_PC3_Human0.92963775
119TRIM28_21343339_ChIP-Seq_HEK293_Human0.92922807
120HNF4A_19822575_ChIP-Seq_HepG2_Human0.91768091
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89340291
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87739854
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87332914
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86761725
125NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86042772
126TET1_21451524_ChIP-Seq_MESCs_Mouse0.84811914
127STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.83866294
128TP53_20018659_ChIP-ChIP_R1E_Mouse0.82989349
129MYC_19915707_ChIP-ChIP_AK7_Human0.82445174
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76590946
131RXRA_24833708_ChIP-Seq_LIVER_Mouse0.73327181
132GATA1_26923725_Chip-Seq_HPCs_Mouse0.71127528
133MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.71039106
134MYC_27129775_Chip-Seq_CORNEA_Mouse0.70051367
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.70029991
136SOX3_22085726_ChIP-Seq_NPCs_Mouse0.68978102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.32714902
2MP0004859_abnormal_synaptic_plasticity4.48881721
3MP0002837_dystrophic_cardiac_calcinosis3.55947484
4MP0003283_abnormal_digestive_organ3.27288961
5MP0005365_abnormal_bile_salt3.16459182
6MP0008875_abnormal_xenobiotic_pharmacok3.10763346
7MP0003195_calcinosis2.97779150
8MP0005085_abnormal_gallbladder_physiolo2.89804539
9MP0004084_abnormal_cardiac_muscle2.86563055
10MP0005360_urolithiasis2.83427936
11MP0003635_abnormal_synaptic_transmissio2.77679197
12MP0000751_myopathy2.74915379
13MP0002909_abnormal_adrenal_gland2.59903286
14MP0004215_abnormal_myocardial_fiber2.51142816
15MP0003646_muscle_fatigue2.50950294
16MP0004270_analgesia2.47329475
17MP0009780_abnormal_chondrocyte_physiolo2.12721809
18MP0002063_abnormal_learning/memory/cond2.12420975
19MP0003880_abnormal_central_pattern2.09742526
20MP0004233_abnormal_muscle_weight2.07529636
21MP0003137_abnormal_impulse_conducting2.02259635
22MP0009046_muscle_twitch2.00407624
23MP0004036_abnormal_muscle_relaxation1.99523904
24MP0002822_catalepsy1.99053854
25MP0002064_seizures1.94868556
26MP0004858_abnormal_nervous_system1.92694506
27MP0009745_abnormal_behavioral_response1.92190404
28MP0003252_abnormal_bile_duct1.90767538
29MP0002653_abnormal_ependyma_morphology1.76553682
30MP0005332_abnormal_amino_acid1.72903178
31MP0010329_abnormal_lipoprotein_level1.70032987
32MP0003868_abnormal_feces_composition1.69056528
33MP0002572_abnormal_emotion/affect_behav1.66390963
34MP0005330_cardiomyopathy1.65475698
35MP0002269_muscular_atrophy1.64487406
36MP0005623_abnormal_meninges_morphology1.64254349
37MP0003690_abnormal_glial_cell1.61094817
38MP0002272_abnormal_nervous_system1.59511258
39MP0002876_abnormal_thyroid_physiology1.58597356
40MP0008961_abnormal_basal_metabolism1.56172662
41MP0001486_abnormal_startle_reflex1.55302273
42MP0004085_abnormal_heartbeat1.52225091
43MP0004145_abnormal_muscle_electrophysio1.52108650
44MP0004087_abnormal_muscle_fiber1.47697514
45MP0004885_abnormal_endolymph1.44142851
46MP0002734_abnormal_mechanical_nocicepti1.43971141
47MP0001666_abnormal_nutrient_absorption1.41424379
48MP0006072_abnormal_retinal_apoptosis1.41128590
49MP0005423_abnormal_somatic_nervous1.41065327
50MP0002138_abnormal_hepatobiliary_system1.39281410
51MP0002877_abnormal_melanocyte_morpholog1.38283745
52MP0008775_abnormal_heart_ventricle1.37544674
53MP0005377_hearing/vestibular/ear_phenot1.36791604
54MP0003878_abnormal_ear_physiology1.36791604
55MP0008569_lethality_at_weaning1.36474629
56MP0000749_muscle_degeneration1.35630554
57MP0004811_abnormal_neuron_physiology1.34402582
58MP0000955_abnormal_spinal_cord1.32391888
59MP0002972_abnormal_cardiac_muscle1.30461894
60MP0002234_abnormal_pharynx_morphology1.28796619
61MP0004133_heterotaxia1.26766468
62MP0003122_maternal_imprinting1.26586130
63MP0000013_abnormal_adipose_tissue1.25952920
64MP0004043_abnormal_pH_regulation1.24156069
65MP0006276_abnormal_autonomic_nervous1.23582826
66MP0000920_abnormal_myelination1.23529464
67MP0000747_muscle_weakness1.22719247
68MP0003329_amyloid_beta_deposits1.21973861
69MP0004924_abnormal_behavior1.21594944
70MP0005386_behavior/neurological_phenoty1.21594944
71MP0001440_abnormal_grooming_behavior1.20241474
72MP0002736_abnormal_nociception_after1.18816909
73MP0005620_abnormal_muscle_contractility1.18381966
74MP0002733_abnormal_thermal_nociception1.17819674
75MP0010630_abnormal_cardiac_muscle1.16602933
76MP0006138_congestive_heart_failure1.13016158
77MP0004130_abnormal_muscle_cell1.12997304
78MP0000566_synostosis1.11819874
79MP0001970_abnormal_pain_threshold1.10442759
80MP0004484_altered_response_of1.09762734
81MP0003119_abnormal_digestive_system1.09371658
82MP0003123_paternal_imprinting1.07866405
83MP0002106_abnormal_muscle_physiology1.06776728
84MP0003787_abnormal_imprinting1.05623690
85MP0002184_abnormal_innervation1.05141881
86MP0001984_abnormal_olfaction1.04604375
87MP0002882_abnormal_neuron_morphology1.04381666
88MP0002067_abnormal_sensory_capabilities1.03532741
89MP0001544_abnormal_cardiovascular_syste1.02568087
90MP0005385_cardiovascular_system_phenoty1.02568087
91MP0005535_abnormal_body_temperature1.02091461
92MP0000750_abnormal_muscle_regeneration1.01740486
93MP0002066_abnormal_motor_capabilities/c1.01005642
94MP0004742_abnormal_vestibular_system1.00058710
95MP0002118_abnormal_lipid_homeostasis0.99679540
96MP0000778_abnormal_nervous_system0.99634066
97MP0001968_abnormal_touch/_nociception0.99581334
98MP0000759_abnormal_skeletal_muscle0.99369259
99MP0003633_abnormal_nervous_system0.98347583
100MP0002557_abnormal_social/conspecific_i0.97067885
101MP0000604_amyloidosis0.95549160
102MP0002152_abnormal_brain_morphology0.95419231
103MP0002249_abnormal_larynx_morphology0.95266678
104MP0002127_abnormal_cardiovascular_syste0.94600959
105MP0005187_abnormal_penis_morphology0.94254001
106MP0008872_abnormal_physiological_respon0.94161799
107MP0008874_decreased_physiological_sensi0.94014520
108MP0005369_muscle_phenotype0.91946026
109MP0001963_abnormal_hearing_physiology0.91803609
110MP0000003_abnormal_adipose_tissue0.91235593
111MP0005646_abnormal_pituitary_gland0.90811321
112MP0003705_abnormal_hypodermis_morpholog0.85932485
113MP0001501_abnormal_sleep_pattern0.85899024
114MP0003634_abnormal_glial_cell0.85263334
115MP0001756_abnormal_urination0.83798534
116MP0001502_abnormal_circadian_rhythm0.83450139
117MP0001661_extended_life_span0.82429058
118MP0001177_atelectasis0.81910833
119MP0002229_neurodegeneration0.80632722
120MP0002638_abnormal_pupillary_reflex0.78798779
121MP0003631_nervous_system_phenotype0.78704013
122MP0001299_abnormal_eye_distance/0.78058766
123MP0001905_abnormal_dopamine_level0.77784212
124MP0001348_abnormal_lacrimal_gland0.77633658
125MP0003890_abnormal_embryonic-extraembry0.76832005
126MP0010234_abnormal_vibrissa_follicle0.76208838
127MP0004019_abnormal_vitamin_homeostasis0.74939643
128MP0003172_abnormal_lysosome_physiology0.74706709
129MP0005645_abnormal_hypothalamus_physiol0.74565262
130MP0005076_abnormal_cell_differentiation0.74556761
131MP0001485_abnormal_pinna_reflex0.73517302
132MP0003861_abnormal_nervous_system0.73397763
133MP0002084_abnormal_developmental_patter0.73225494
134MP0002332_abnormal_exercise_endurance0.72425379
135MP0005584_abnormal_enzyme/coenzyme_acti0.71470627
136MP0002069_abnormal_eating/drinking_beha0.69990938
137MP0004142_abnormal_muscle_tone0.69866597
138MP0003632_abnormal_nervous_system0.69306848
139MP0003879_abnormal_hair_cell0.68473153
140MP0001346_abnormal_lacrimal_gland0.67752247
141MP0003075_altered_response_to0.67304045
142MP0002735_abnormal_chemical_nociception0.67044583
143MP0000639_abnormal_adrenal_gland0.66576284
144MP0002090_abnormal_vision0.62601375
145MP0000681_abnormal_thyroid_gland0.59180336
146MP0009672_abnormal_birth_weight0.57760657
147MP0005551_abnormal_eye_electrophysiolog0.57637808
148MP0002078_abnormal_glucose_homeostasis0.57454564
149MP0005636_abnormal_mineral_homeostasis0.57141474
150MP0000609_abnormal_liver_physiology0.56850269

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.54168815
2Abnormality of monocarboxylic acid metabolism (HP:0010996)6.28773029
3Deep venous thrombosis (HP:0002625)6.12218055
4Prolonged partial thromboplastin time (HP:0003645)5.54350064
5Complement deficiency (HP:0004431)5.41313605
6Hypobetalipoproteinemia (HP:0003563)4.39145157
7Abnormality of complement system (HP:0005339)4.20212142
8Sudden death (HP:0001699)4.02097487
9Myokymia (HP:0002411)3.92521821
10Visual hallucinations (HP:0002367)3.76384136
11Conjugated hyperbilirubinemia (HP:0002908)3.75406950
12Bundle branch block (HP:0011710)3.73965997
13Abnormality of the lower motor neuron (HP:0002366)3.70194394
14Joint hemorrhage (HP:0005261)3.66740262
15Hyperlipoproteinemia (HP:0010980)3.60096848
16Ventricular fibrillation (HP:0001663)3.54816562
17Glomerulonephritis (HP:0000099)3.50867851
18Focal motor seizures (HP:0011153)3.32469055
19Atrial fibrillation (HP:0005110)3.17196348
20Focal seizures (HP:0007359)3.12771858
21Primary atrial arrhythmia (HP:0001692)3.10670171
22Ependymoma (HP:0002888)3.09483924
23Systemic lupus erythematosus (HP:0002725)3.07517164
24Increased circulating renin level (HP:0000848)3.04059015
25Xanthomatosis (HP:0000991)3.02543962
26Status epilepticus (HP:0002133)2.96399305
27Supraventricular tachycardia (HP:0004755)2.95014905
28Astrocytoma (HP:0009592)2.93762342
29Abnormality of the astrocytes (HP:0100707)2.93762342
30Intrahepatic cholestasis (HP:0001406)2.93155394
31Prolonged QT interval (HP:0001657)2.92203747
32Neurofibrillary tangles (HP:0002185)2.91833264
33Supraventricular arrhythmia (HP:0005115)2.89681307
34Dysmetric saccades (HP:0000641)2.89143958
35Torticollis (HP:0000473)2.85234215
36Exercise-induced muscle cramps (HP:0003710)2.83459008
37Syncope (HP:0001279)2.79615374
38Exercise-induced myalgia (HP:0003738)2.78903235
39Hyperinsulinemic hypoglycemia (HP:0000825)2.78869580
40Ventricular tachycardia (HP:0004756)2.78098850
41Resting tremor (HP:0002322)2.67686134
42Depression (HP:0000716)2.64494890
43Action tremor (HP:0002345)2.62959650
44Heart block (HP:0012722)2.62192709
45Abnormal EKG (HP:0003115)2.59170139
46Ventricular arrhythmia (HP:0004308)2.57122293
47Dysdiadochokinesis (HP:0002075)2.53844869
48Intention tremor (HP:0002080)2.52467548
49Cerebral inclusion bodies (HP:0100314)2.51316504
50Abnormality of binocular vision (HP:0011514)2.49879826
51Diplopia (HP:0000651)2.49879826
52Ankle clonus (HP:0011448)2.47699257
53Atrioventricular block (HP:0001678)2.47341390
54Hypolipoproteinemia (HP:0010981)2.46372269
55Epileptiform EEG discharges (HP:0011182)2.45553089
56Nephritis (HP:0000123)2.45503772
57Spastic gait (HP:0002064)2.40460850
58Abnormal atrioventricular conduction (HP:0005150)2.40443373
59Focal dystonia (HP:0004373)2.39416424
60Abnormality of the intrinsic pathway (HP:0010989)2.38746041
61Postural instability (HP:0002172)2.38568212
62Tetraplegia (HP:0002445)2.37792303
63Myoglobinuria (HP:0002913)2.36611416
64Insomnia (HP:0100785)2.36462214
65Obstructive sleep apnea (HP:0002870)2.32543947
66Abnormal gallbladder physiology (HP:0012438)2.31234935
67Cholecystitis (HP:0001082)2.31234935
68Difficulty running (HP:0009046)2.30881655
69Hyporeflexia of lower limbs (HP:0002600)2.30719649
70Calf muscle hypertrophy (HP:0008981)2.26937318
71Craniofacial dystonia (HP:0012179)2.26143950
72Aplasia involving bones of the upper limbs (HP:0009823)2.26075364
73Aplasia of the phalanges of the hand (HP:0009802)2.26075364
74Aplasia involving bones of the extremities (HP:0009825)2.26075364
75Epileptic encephalopathy (HP:0200134)2.25333883
76EMG: neuropathic changes (HP:0003445)2.24020701
77EEG with generalized epileptiform discharges (HP:0011198)2.23644010
78Pheochromocytoma (HP:0002666)2.23346304
79Supranuclear gaze palsy (HP:0000605)2.22775023
80Abnormality of the common coagulation pathway (HP:0010990)2.22206139
81Spontaneous abortion (HP:0005268)2.21728518
82Poor eye contact (HP:0000817)2.21591152
83Neoplasm of the heart (HP:0100544)2.20839118
84Abnormal eating behavior (HP:0100738)2.20784210
85Amblyopia (HP:0000646)2.20476134
86Bronchomalacia (HP:0002780)2.20204467
87Abnormal social behavior (HP:0012433)2.19490200
88Impaired social interactions (HP:0000735)2.19490200
89Absence seizures (HP:0002121)2.17724131
90Impaired vibration sensation in the lower limbs (HP:0002166)2.15917385
91Large for gestational age (HP:0001520)2.15806466
92Annular pancreas (HP:0001734)2.15604545
93Scanning speech (HP:0002168)2.15311457
94Upper limb amyotrophy (HP:0009129)2.14859833
95Distal upper limb amyotrophy (HP:0007149)2.14859833
96Abnormality of the salivary glands (HP:0010286)2.14303161
97Pointed chin (HP:0000307)2.14256814
98Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.13141854
99Impaired smooth pursuit (HP:0007772)2.12885866
100Atonic seizures (HP:0010819)2.12505868
101Generalized tonic-clonic seizures (HP:0002069)2.11444388
102Hyperglycinemia (HP:0002154)2.10409714
103Hypsarrhythmia (HP:0002521)2.09966138
104Hypercholesterolemia (HP:0003124)2.09865500
105Urinary bladder sphincter dysfunction (HP:0002839)2.09844037
106Abnormality of the calf musculature (HP:0001430)2.08565415
107Abnormality of glutamine family amino acid metabolism (HP:0010902)2.08229592
108Myotonia (HP:0002486)2.07015248
109Glioma (HP:0009733)2.07004807
110Gout (HP:0001997)2.04737457
111Hemiparesis (HP:0001269)2.04495237
112Vascular calcification (HP:0004934)2.03506504
113Mitral stenosis (HP:0001718)2.02716767
114Abnormality of pyrimidine metabolism (HP:0004353)2.02447615
115Osteomalacia (HP:0002749)2.01971933
116Abnormality of glycine metabolism (HP:0010895)2.01624909
117Abnormality of serine family amino acid metabolism (HP:0010894)2.01624909
118Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.01202356
119Hemiplegia (HP:0002301)2.01193347
120Dialeptic seizures (HP:0011146)1.99175778
121Hypercortisolism (HP:0001578)1.98701179
122Progressive cerebellar ataxia (HP:0002073)1.98671479
123Neonatal onset (HP:0003623)1.98473615
124Hyperacusis (HP:0010780)1.98371596
125Central scotoma (HP:0000603)1.98297781
126Febrile seizures (HP:0002373)1.97189411
127Rapidly progressive (HP:0003678)1.96341092
128Urinary urgency (HP:0000012)1.96033483
129Rickets (HP:0002748)1.95787955
130Hyperglycinuria (HP:0003108)1.95768822
131Cerebral hypomyelination (HP:0006808)1.94991014
132Turricephaly (HP:0000262)1.94849370
133Clonus (HP:0002169)1.94267891
134Sleep apnea (HP:0010535)1.94247122
135Difficulty climbing stairs (HP:0003551)1.93104521
136Hand muscle atrophy (HP:0009130)1.92942311
137Limb dystonia (HP:0002451)1.92706764
138Muscle hypertrophy of the lower extremities (HP:0008968)1.92597129
139Ketoacidosis (HP:0001993)1.91904998
140Pancreatic islet-cell hyperplasia (HP:0004510)1.90471885
141Truncal ataxia (HP:0002078)1.90183997
142Bifid scrotum (HP:0000048)1.88080531
143Hypoalphalipoproteinemia (HP:0003233)1.87792629
144Abnormality of the left ventricular outflow tract (HP:0011103)1.87295144
145Subaortic stenosis (HP:0001682)1.87295144
146Delayed CNS myelination (HP:0002188)1.85020235
147Hyperthyroidism (HP:0000836)1.84392093
148Anxiety (HP:0000739)1.83796498
149Irritability (HP:0000737)1.83748364
150Akinesia (HP:0002304)1.82364688
151Alacrima (HP:0000522)1.82024972
152Abnormality of ocular smooth pursuit (HP:0000617)1.82022763
153Left ventricular hypertrophy (HP:0001712)1.81691224
154Neonatal hypoglycemia (HP:0001998)1.81615085
155Asymmetric septal hypertrophy (HP:0001670)1.81412568
156Ankyloglossia (HP:0010296)1.81325080
157Dysmetria (HP:0001310)1.81115282
158Lower limb amyotrophy (HP:0007210)1.80699635
159Adenoma sebaceum (HP:0009720)1.79850575
160Angiofibromas (HP:0010615)1.79850575
161Bradykinesia (HP:0002067)1.79569766
162Neoplasm of the peripheral nervous system (HP:0100007)1.79523328
163Morphological abnormality of the pyramidal tract (HP:0002062)1.79322113
164Impaired vibratory sensation (HP:0002495)1.78710966
165Right ventricular cardiomyopathy (HP:0011663)1.73096915
166Athetosis (HP:0002305)1.73079188
167Genetic anticipation (HP:0003743)1.72979000
168Abnormality of endocrine pancreas physiology (HP:0012093)1.72964847
169Abnormality of the pancreatic islet cells (HP:0006476)1.72964847
170Muscle fiber splitting (HP:0003555)1.72076112
171Papilledema (HP:0001085)1.71730404
172Hamartoma of the eye (HP:0010568)1.71518663
173Palpitations (HP:0001962)1.70945471

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.47284321
2NTRK33.16968800
3PRKD33.15125291
4NEK12.79461159
5EPHA42.78648596
6LMTK22.48156527
7PAK62.33023061
8PHKG12.25973381
9PHKG22.25973381
10MAP3K42.17936483
11NTRK12.13149779
12KSR22.11201233
13STK381.86516795
14TYRO31.83658898
15ICK1.81490173
16NTRK21.80857041
17MINK11.73723792
18MARK11.72172243
19ARAF1.68828176
20TRIB31.67746060
21UHMK11.66402210
22RIPK11.65874310
23PDGFRA1.64496959
24LATS21.60123606
25ALK1.60007560
26CAMKK11.58121469
27PKN21.53433564
28PINK11.52277600
29TTN1.49376173
30SCYL21.48127963
31KSR11.44984618
32FGFR21.44013095
33PDK31.42925795
34PDK41.42925795
35DAPK21.38194360
36CDC42BPA1.36169570
37PLK21.31258282
38CDK121.29981808
39OXSR11.29521745
40CAMK2B1.28963321
41PAK31.28653455
42CASK1.20711011
43MAP3K21.09893805
44DMPK1.09074251
45DYRK1A1.05069694
46SGK21.03279396
47DAPK11.02554853
48CDK51.02159235
49MAP2K41.00301779
50WNK10.98763552
51DDR20.96596353
52PRKCH0.93051142
53GRK50.91918014
54PNCK0.91322182
55RET0.90130279
56CDK190.90090888
57FGFR40.89166401
58TAOK10.82752412
59CAMK2G0.79969741
60MAP2K60.79121946
61STK110.78953449
62NEK60.78358684
63WNK30.77744820
64PASK0.74529143
65MAPK120.74475096
66CAMK40.71608163
67BRSK10.69890263
68CAMK1D0.69068494
69RIPK40.69061579
70MAP3K130.67238874
71CDK150.66699853
72CAMK2D0.65687660
73PRKAA10.65489797
74INSRR0.65362437
75PRKD10.65132333
76PRKCG0.65087778
77CDK180.64829726
78PDK20.63943145
79MTOR0.61639633
80MAP3K10.61512050
81MARK20.61410558
82SMG10.61062026
83BMX0.60986985
84CAMK10.60317799
85RPS6KA30.59830958
86MAPK100.59459317
87SGK30.59330423
88ERBB20.59269460
89FER0.58370605
90PRKCZ0.58077513
91DAPK30.58068767
92TNK20.58065214
93CDK140.57919682
94CDK11A0.56872084
95CAMK2A0.56830282
96HIPK20.56721279
97PRPF4B0.56108556
98EEF2K0.53594381
99CAMKK20.52780991
100PRKD20.51303777
101AKT30.51007879
102BRAF0.50517711
103EPHA20.50082321
104MAP2K70.49832788
105SGK10.49578174
106SGK4940.48275430
107SGK2230.48275430
108ROCK10.48006967
109MAPK130.48004417
110PTK20.47200771
111MAP3K70.46494207
112SIK20.44908883
113CSNK1E0.44473444
114SIK10.42988335
115CSNK1G20.42302803
116MAP3K120.39608068
117PDK10.39167841
118GSK3B0.38742865
119PDPK10.38014547
120PRKCA0.36927416
121CAMK1G0.36205696
122PRKACA0.35384281
123PRKACG0.35055632
124MAPKAPK50.34773945
125CSNK1D0.34598614
126AKT20.34178224
127PRKDC0.34167865
128MAPK80.33911941
129CDK20.30737601
130FGFR10.30025262
131PRKACB0.29728496

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002322.94424540
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.58297237
3Arginine biosynthesis_Homo sapiens_hsa002202.57055166
4Synaptic vesicle cycle_Homo sapiens_hsa047212.51089314
5Vitamin B6 metabolism_Homo sapiens_hsa007502.49127937
6Complement and coagulation cascades_Homo sapiens_hsa046102.42694482
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.40826816
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.33841661
9Insulin secretion_Homo sapiens_hsa049112.31450905
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26054854
11Retinol metabolism_Homo sapiens_hsa008302.22979325
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.22601168
13GABAergic synapse_Homo sapiens_hsa047272.15500745
14Circadian entrainment_Homo sapiens_hsa047132.12281956
15Nicotine addiction_Homo sapiens_hsa050332.12193974
16Phenylalanine metabolism_Homo sapiens_hsa003602.11910405
17Long-term potentiation_Homo sapiens_hsa047202.11801526
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.09273228
19Olfactory transduction_Homo sapiens_hsa047402.04826772
20* Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97639959
21Cardiac muscle contraction_Homo sapiens_hsa042601.91430851
22Fatty acid degradation_Homo sapiens_hsa000711.89841846
23Dilated cardiomyopathy_Homo sapiens_hsa054141.88722265
24Type II diabetes mellitus_Homo sapiens_hsa049301.88549119
25Amphetamine addiction_Homo sapiens_hsa050311.85281606
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84500296
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84340991
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82863538
29Glutamatergic synapse_Homo sapiens_hsa047241.82049329
30Nitrogen metabolism_Homo sapiens_hsa009101.80994234
31Tyrosine metabolism_Homo sapiens_hsa003501.78309405
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.77396138
33Morphine addiction_Homo sapiens_hsa050321.75917832
34Chemical carcinogenesis_Homo sapiens_hsa052041.75675907
35Butanoate metabolism_Homo sapiens_hsa006501.75506803
36Histidine metabolism_Homo sapiens_hsa003401.72062221
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71405260
38Dopaminergic synapse_Homo sapiens_hsa047281.67680364
39Gastric acid secretion_Homo sapiens_hsa049711.55579025
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54949582
41Salivary secretion_Homo sapiens_hsa049701.53298682
42Cholinergic synapse_Homo sapiens_hsa047251.51295567
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.50440515
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50156763
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47420067
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.46267648
47Oxytocin signaling pathway_Homo sapiens_hsa049211.40693015
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.38234975
49mTOR signaling pathway_Homo sapiens_hsa041501.36005042
50Cocaine addiction_Homo sapiens_hsa050301.35680148
51Arginine and proline metabolism_Homo sapiens_hsa003301.34451724
52Gap junction_Homo sapiens_hsa045401.33990936
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33374897
54Taste transduction_Homo sapiens_hsa047421.32848950
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.28866429
56Renin secretion_Homo sapiens_hsa049241.27477167
57GnRH signaling pathway_Homo sapiens_hsa049121.26752558
58Estrogen signaling pathway_Homo sapiens_hsa049151.26547615
59Calcium signaling pathway_Homo sapiens_hsa040201.26238516
60beta-Alanine metabolism_Homo sapiens_hsa004101.21055548
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.18552471
62Oocyte meiosis_Homo sapiens_hsa041141.18077019
63cAMP signaling pathway_Homo sapiens_hsa040241.17191831
64Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15790486
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.14361615
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13013168
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12548230
68Glucagon signaling pathway_Homo sapiens_hsa049221.12335331
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08627128
70Dorso-ventral axis formation_Homo sapiens_hsa043201.08623069
71Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07711453
72Long-term depression_Homo sapiens_hsa047301.06719658
73* Tryptophan metabolism_Homo sapiens_hsa003801.06478726
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06083745
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06076611
76Glioma_Homo sapiens_hsa052141.03670752
77Melanogenesis_Homo sapiens_hsa049160.97981945
78PPAR signaling pathway_Homo sapiens_hsa033200.93046507
79Pyruvate metabolism_Homo sapiens_hsa006200.92814840
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.92471774
81Linoleic acid metabolism_Homo sapiens_hsa005910.92189483
82Insulin signaling pathway_Homo sapiens_hsa049100.91539833
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88998661
84Serotonergic synapse_Homo sapiens_hsa047260.88921487
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88501365
86Starch and sucrose metabolism_Homo sapiens_hsa005000.84448968
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.84443238
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83527213
89ErbB signaling pathway_Homo sapiens_hsa040120.82635580
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81934341
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.81925676
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81192548
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79967520
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.79298680
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78956835
96Pancreatic secretion_Homo sapiens_hsa049720.78604222
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78422190
98Fatty acid metabolism_Homo sapiens_hsa012120.76041049
99Tight junction_Homo sapiens_hsa045300.72873278
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72548135
101Thyroid hormone synthesis_Homo sapiens_hsa049180.72316874
102Peroxisome_Homo sapiens_hsa041460.70799972
103Biosynthesis of amino acids_Homo sapiens_hsa012300.70551742
104Alcoholism_Homo sapiens_hsa050340.70496539
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.68507026
106Fatty acid biosynthesis_Homo sapiens_hsa000610.66918043
107Hippo signaling pathway_Homo sapiens_hsa043900.65594850
108Endometrial cancer_Homo sapiens_hsa052130.64711776
109Hedgehog signaling pathway_Homo sapiens_hsa043400.64304807
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63552831
111ABC transporters_Homo sapiens_hsa020100.63486165
112Type I diabetes mellitus_Homo sapiens_hsa049400.63158766
113Circadian rhythm_Homo sapiens_hsa047100.63036614
114Inositol phosphate metabolism_Homo sapiens_hsa005620.62919593
115VEGF signaling pathway_Homo sapiens_hsa043700.62840560
116AMPK signaling pathway_Homo sapiens_hsa041520.62720179
117Insulin resistance_Homo sapiens_hsa049310.61138818
118MAPK signaling pathway_Homo sapiens_hsa040100.60349514
119Axon guidance_Homo sapiens_hsa043600.59906842
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58679979
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58543102
122Renal cell carcinoma_Homo sapiens_hsa052110.57812976
123Vibrio cholerae infection_Homo sapiens_hsa051100.56062487
124* Carbon metabolism_Homo sapiens_hsa012000.55024766
125Wnt signaling pathway_Homo sapiens_hsa043100.54168759
126Rap1 signaling pathway_Homo sapiens_hsa040150.54150816
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53059995
128Arachidonic acid metabolism_Homo sapiens_hsa005900.51839573
129Fructose and mannose metabolism_Homo sapiens_hsa000510.51360105
130Choline metabolism in cancer_Homo sapiens_hsa052310.51107587
131Non-small cell lung cancer_Homo sapiens_hsa052230.48962320
132Prion diseases_Homo sapiens_hsa050200.48043665
133Propanoate metabolism_Homo sapiens_hsa006400.47439820
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46034994
135HIF-1 signaling pathway_Homo sapiens_hsa040660.45161520
136Endocytosis_Homo sapiens_hsa041440.44751434
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42407742
138Collecting duct acid secretion_Homo sapiens_hsa049660.42172156
139Adherens junction_Homo sapiens_hsa045200.41457634
140Proteoglycans in cancer_Homo sapiens_hsa052050.41064673
141Bile secretion_Homo sapiens_hsa049760.40886067
142Folate biosynthesis_Homo sapiens_hsa007900.35415928
143Pentose phosphate pathway_Homo sapiens_hsa000300.27687061
144Sulfur relay system_Homo sapiens_hsa041220.26286143
145* Metabolic pathways_Homo sapiens_hsa011000.23757957
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23714500

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