OGFOD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.67516805
2synaptic vesicle maturation (GO:0016188)6.34958309
3locomotory exploration behavior (GO:0035641)5.93766273
4synaptic vesicle exocytosis (GO:0016079)5.69866436
5glutamate secretion (GO:0014047)5.62912101
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.61472486
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.60928462
8vocalization behavior (GO:0071625)5.34402603
9regulation of synaptic vesicle exocytosis (GO:2000300)5.33198453
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.27658676
11regulation of glutamate receptor signaling pathway (GO:1900449)4.97809650
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.95636723
13neurotransmitter secretion (GO:0007269)4.86919775
14regulation of synaptic vesicle transport (GO:1902803)4.84252167
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.72188281
16neuronal action potential propagation (GO:0019227)4.63878918
17regulation of neuronal synaptic plasticity (GO:0048168)4.60498673
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.59483436
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.56863135
20exploration behavior (GO:0035640)4.48877591
21cellular potassium ion homeostasis (GO:0030007)4.47507082
22ribosome assembly (GO:0042255)4.41908948
23sodium ion export (GO:0071436)4.32403947
24protein localization to synapse (GO:0035418)4.31205625
25IMP biosynthetic process (GO:0006188)4.23457370
26mitotic metaphase plate congression (GO:0007080)4.18895520
27proline transport (GO:0015824)4.17335038
28regulation of synapse structural plasticity (GO:0051823)4.17243508
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.14472476
30DNA replication checkpoint (GO:0000076)4.12281751
31glutamate receptor signaling pathway (GO:0007215)4.11137323
32neuromuscular process controlling posture (GO:0050884)4.09901717
33long-term memory (GO:0007616)4.08943990
34nuclear pore complex assembly (GO:0051292)4.08005597
35synaptic transmission, glutamatergic (GO:0035249)4.05309130
36DNA strand elongation involved in DNA replication (GO:0006271)4.04679553
37gamma-aminobutyric acid transport (GO:0015812)4.04503117
38chromatin remodeling at centromere (GO:0031055)4.02729459
39activation of protein kinase A activity (GO:0034199)4.01203766
40establishment of integrated proviral latency (GO:0075713)4.01111481
41neuron cell-cell adhesion (GO:0007158)4.00732027
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.00718020
43neuron-neuron synaptic transmission (GO:0007270)3.98916418
44nuclear pore organization (GO:0006999)3.96680645
45CENP-A containing nucleosome assembly (GO:0034080)3.95996282
46neurotransmitter transport (GO:0006836)3.95498324
47proteasome assembly (GO:0043248)3.90901213
48DNA strand elongation (GO:0022616)3.88818212
49IMP metabolic process (GO:0046040)3.84531142
50layer formation in cerebral cortex (GO:0021819)3.80756408
51neurotransmitter-gated ion channel clustering (GO:0072578)3.80324634
52cullin deneddylation (GO:0010388)3.76473644
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.76019721
54cell communication by electrical coupling (GO:0010644)3.73197394
55metaphase plate congression (GO:0051310)3.73022444
56maturation of 5.8S rRNA (GO:0000460)3.71912842
57regulation of neurotransmitter levels (GO:0001505)3.71113563
58regulation of synaptic plasticity (GO:0048167)3.69980960
59positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.67133530
60cerebellar Purkinje cell differentiation (GO:0021702)3.66502000
61protein deneddylation (GO:0000338)3.66253570
62positive regulation of membrane potential (GO:0045838)3.65522213
63dendritic spine morphogenesis (GO:0060997)3.64038374
64protein localization to kinetochore (GO:0034501)3.63096680
65purine nucleobase biosynthetic process (GO:0009113)3.62708963
66regulation of postsynaptic membrane potential (GO:0060078)3.61194089
67long-term synaptic potentiation (GO:0060291)3.59736944
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.59560411
69telomere maintenance via semi-conservative replication (GO:0032201)3.58400182
70gamma-aminobutyric acid signaling pathway (GO:0007214)3.56470365
71synaptic vesicle endocytosis (GO:0048488)3.55916277
72vesicle transport along microtubule (GO:0047496)3.54873902
73nucleobase biosynthetic process (GO:0046112)3.52881669
74neuromuscular process controlling balance (GO:0050885)3.52341443
75tRNA aminoacylation for protein translation (GO:0006418)3.51458937
76DNA double-strand break processing (GO:0000729)3.49745152
77amino acid activation (GO:0043038)3.48707743
78tRNA aminoacylation (GO:0043039)3.48707743
79positive regulation of synapse maturation (GO:0090129)3.46017275
80histone exchange (GO:0043486)3.43233566
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.42966515
82response to histamine (GO:0034776)3.41291269
83positive regulation of synaptic transmission, GABAergic (GO:0032230)3.40623795
84regulation of neurotransmitter secretion (GO:0046928)3.36348020
85regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.35497094
86double-strand break repair via nonhomologous end joining (GO:0006303)3.33581798
87non-recombinational repair (GO:0000726)3.33581798
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.32508349
89somatic diversification of immune receptors via somatic mutation (GO:0002566)3.31529655
90somatic hypermutation of immunoglobulin genes (GO:0016446)3.31529655
91regulation of synaptic transmission, glutamatergic (GO:0051966)3.31448391
92folic acid-containing compound biosynthetic process (GO:0009396)3.31226180
93regulation of dendritic spine morphogenesis (GO:0061001)3.31025342
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30233976
95mitotic nuclear envelope disassembly (GO:0007077)3.29515476
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.29266296
97membrane depolarization during action potential (GO:0086010)3.28870690
98negative regulation of synaptic transmission, GABAergic (GO:0032229)3.26488958
99regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25592936
100DNA replication-dependent nucleosome assembly (GO:0006335)3.24659945
101DNA replication-dependent nucleosome organization (GO:0034723)3.24659945
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.24529062
103mitotic sister chromatid segregation (GO:0000070)3.24294252
104formation of translation preinitiation complex (GO:0001731)3.22534184
105negative regulation of DNA-dependent DNA replication (GO:2000104)3.22121871
106regulation of mitochondrial translation (GO:0070129)3.21553231
107transmission of nerve impulse (GO:0019226)3.21516706
108regulation of vesicle fusion (GO:0031338)3.21099549
109regulation of clathrin-mediated endocytosis (GO:2000369)3.20886493
110G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.19133036
111regulation of centriole replication (GO:0046599)3.18873729
112behavioral defense response (GO:0002209)3.18473436
113behavioral fear response (GO:0001662)3.18473436
114replication fork processing (GO:0031297)3.18091094
115glycine transport (GO:0015816)3.17614153
116DNA catabolic process, exonucleolytic (GO:0000738)3.17365502
117mitochondrial RNA metabolic process (GO:0000959)3.17034819
118potassium ion import (GO:0010107)3.17021936
119protein K6-linked ubiquitination (GO:0085020)3.16897670
120establishment of chromosome localization (GO:0051303)3.16887743
121telomere maintenance via recombination (GO:0000722)3.16625497
122ribosome biogenesis (GO:0042254)3.16423495
123rRNA modification (GO:0000154)3.15780998
124regulation of neurotransmitter transport (GO:0051588)3.14997264
125neuron recognition (GO:0008038)3.14366791
126positive regulation of neurotransmitter transport (GO:0051590)3.13864182
127mitotic recombination (GO:0006312)3.13777477
128protein localization to chromosome, centromeric region (GO:0071459)3.13264036
129DNA replication-independent nucleosome organization (GO:0034724)3.13131201
130DNA replication-independent nucleosome assembly (GO:0006336)3.13131201
131positive regulation of synaptic transmission (GO:0050806)3.12996032
132social behavior (GO:0035176)3.10633096
133intraspecies interaction between organisms (GO:0051703)3.10633096
134DNA replication initiation (GO:0006270)3.10318372
135cellular sodium ion homeostasis (GO:0006883)3.09743237
136spindle checkpoint (GO:0031577)3.09502283
137membrane depolarization (GO:0051899)3.09242843
138prepulse inhibition (GO:0060134)3.08958211
139regulation of ARF protein signal transduction (GO:0032012)3.08667314
140pseudouridine synthesis (GO:0001522)3.08141532
141positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07900591
142chemosensory behavior (GO:0007635)3.06432193
143telomere maintenance via telomerase (GO:0007004)3.05653565
144negative regulation of ligase activity (GO:0051352)3.05264895
145negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.05264895
146regulation of synaptic transmission (GO:0050804)3.05087500
147kinetochore organization (GO:0051383)3.04315543
148innervation (GO:0060384)3.03981276
149synaptic transmission (GO:0007268)3.03677578
150negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.02752766
151neuromuscular process (GO:0050905)3.02292947
152membrane disassembly (GO:0030397)3.02273396
153nuclear envelope disassembly (GO:0051081)3.02273396
154sister chromatid segregation (GO:0000819)3.01572956
155mitotic spindle checkpoint (GO:0071174)3.01391466
156telomere maintenance via telomere lengthening (GO:0010833)3.00681312
157long term synaptic depression (GO:0060292)2.99431703
158DNA unwinding involved in DNA replication (GO:0006268)2.99294964
159L-amino acid import (GO:0043092)2.98697159
160pore complex assembly (GO:0046931)2.98114551
161positive regulation of potassium ion transmembrane transport (GO:1901381)2.98085996
162positive regulation of chromosome segregation (GO:0051984)2.97856706
163membrane hyperpolarization (GO:0060081)2.97732051
164mitotic chromosome condensation (GO:0007076)2.97407695
165establishment of viral latency (GO:0019043)2.96624257
166G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95173416
167nucleotide-excision repair, DNA gap filling (GO:0006297)2.95058823
168fear response (GO:0042596)2.94935342
169response to auditory stimulus (GO:0010996)2.94111823
170learning (GO:0007612)2.93836114
171DNA ligation (GO:0006266)2.92783873
172positive regulation of neurotransmitter secretion (GO:0001956)2.92274088
173L-serine metabolic process (GO:0006563)2.91901393
174establishment of protein localization to mitochondrial membrane (GO:0090151)2.91884144
175potassium ion homeostasis (GO:0055075)2.91879568
176negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.91735531
177cerebellar Purkinje cell layer development (GO:0021680)2.91664617
178regulation of double-strand break repair via homologous recombination (GO:0010569)2.91660369
179regulation of mitotic spindle checkpoint (GO:1903504)2.90975088
180regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90975088
181regulation of helicase activity (GO:0051095)2.87101516
182rRNA methylation (GO:0031167)2.86865230
183negative regulation of mitotic sister chromatid separation (GO:2000816)2.86654655
184negative regulation of sister chromatid segregation (GO:0033046)2.86654655
185negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86654655
186negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.86654655
187negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86654655
188negative regulation of chromosome segregation (GO:0051985)2.86458786
189regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82409279
190regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82409279
191RNA-dependent DNA replication (GO:0006278)2.82172818
192synapsis (GO:0007129)2.81977773
193maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.81297877
194DNA damage response, detection of DNA damage (GO:0042769)2.80953125
195G1/S transition of mitotic cell cycle (GO:0000082)2.80125758
196cell cycle G1/S phase transition (GO:0044843)2.80125758
197spliceosomal snRNP assembly (GO:0000387)2.80087939
198postreplication repair (GO:0006301)2.79219246
199isotype switching (GO:0045190)2.78524141
200somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.78524141

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.37622225
2EZH2_22144423_ChIP-Seq_EOC_Human6.17879485
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.68404409
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.91361197
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.77633333
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.76437407
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.54546515
8GBX2_23144817_ChIP-Seq_PC3_Human3.45774817
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.42203644
10RARB_27405468_Chip-Seq_BRAIN_Mouse3.24645837
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.19847745
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.18948652
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.06140937
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.04554669
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00656956
16REST_21632747_ChIP-Seq_MESCs_Mouse2.99778795
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.96998367
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.91044283
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77515245
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74400069
21DROSHA_22980978_ChIP-Seq_HELA_Human2.74214089
22ELK1_19687146_ChIP-ChIP_HELA_Human2.71472014
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61209657
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58682857
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56893546
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56893546
27* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56881484
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.55992444
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.52680562
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.48258878
31MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47839443
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46078852
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45674624
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44484327
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42487934
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.42243947
37JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39408842
38* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37821271
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.37382830
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36575849
41MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35477750
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29949586
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28651924
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27394513
45IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26606098
46SALL1_21062744_ChIP-ChIP_HESCs_Human2.25804338
47VDR_23849224_ChIP-Seq_CD4+_Human2.23435621
48THAP11_20581084_ChIP-Seq_MESCs_Mouse2.21850264
49NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20380738
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19656274
51AR_21909140_ChIP-Seq_LNCAP_Human2.18495193
52DCP1A_22483619_ChIP-Seq_HELA_Human2.16578930
53* FOXP3_21729870_ChIP-Seq_TREG_Human2.13961914
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.08801609
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07613482
56EZH2_27304074_Chip-Seq_ESCs_Mouse2.01589115
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00615439
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.97768087
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97675413
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96187785
61RNF2_27304074_Chip-Seq_ESCs_Mouse1.94818985
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.94298185
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.93644195
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92758568
65AR_21572438_ChIP-Seq_LNCaP_Human1.90312813
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.89622559
67GABP_19822575_ChIP-Seq_HepG2_Human1.88851483
68* TTF2_22483619_ChIP-Seq_HELA_Human1.84968845
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.83967384
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82911251
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82269353
72SMAD4_21799915_ChIP-Seq_A2780_Human1.81788700
73* SRF_21415370_ChIP-Seq_HL-1_Mouse1.78414107
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.74846481
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.72308989
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71849978
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69789693
78XRN2_22483619_ChIP-Seq_HELA_Human1.66240611
79TAF15_26573619_Chip-Seq_HEK293_Human1.64470559
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64292125
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64003695
82MYC_18940864_ChIP-ChIP_HL60_Human1.61528179
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59335946
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58255338
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.56507577
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.53699591
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.52729967
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.52259257
89ZNF274_21170338_ChIP-Seq_K562_Hela1.49784039
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.49127044
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48413739
92* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47295286
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.46880135
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44271690
95ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42139251
96EWS_26573619_Chip-Seq_HEK293_Human1.40406287
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39635344
98AR_19668381_ChIP-Seq_PC3_Human1.37849264
99STAT3_23295773_ChIP-Seq_U87_Human1.34537738
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34321114
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31731609
102KDM5A_27292631_Chip-Seq_BREAST_Human1.30807600
103EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30735869
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30453372
105AR_25329375_ChIP-Seq_VCAP_Human1.26161845
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.24270253
107P300_19829295_ChIP-Seq_ESCs_Human1.24043415
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23688612
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22893190
110RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22818401
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22646713
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21401899
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18781540
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18333633
115FLI1_27457419_Chip-Seq_LIVER_Mouse1.17654349
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17103906
117NANOG_16153702_ChIP-ChIP_HESCs_Human1.15459426
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.15073639
119TCF4_23295773_ChIP-Seq_U87_Human1.14718309
120NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14694050
121RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13485961
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13340597
123YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13164879
124CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13145605
125KDM2B_26808549_Chip-Seq_K562_Human1.11649662
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11496618
127TP53_16413492_ChIP-PET_HCT116_Human1.10109577
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09197887
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07630280
130ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07502569
131CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06405282
132ARNT_22903824_ChIP-Seq_MCF-7_Human1.05743854
133TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05626483
134RXR_22108803_ChIP-Seq_LS180_Human1.04183301
135ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02760028
136* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02472016
137AHR_22903824_ChIP-Seq_MCF-7_Human1.01917076
138ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01853838
139SOX17_20123909_ChIP-Seq_XEN_Mouse1.00213290
140ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00187791
141DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98869028
142P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98148613
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98134764
144HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97866139
145CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97849916
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97784727
147SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96721940
148ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96023148
149SMAD3_21741376_ChIP-Seq_ESCs_Human0.95909272
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.95662157
151* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95143770
152HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94841182
153MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93740320
154IRF1_19129219_ChIP-ChIP_H3396_Human0.93479695
155SMAD4_21741376_ChIP-Seq_HESCs_Human0.93236682
156SMAD3_21741376_ChIP-Seq_HESCs_Human0.93058899
157SOX2_16153702_ChIP-ChIP_HESCs_Human0.92227710
158TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91821360
159CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90895409
160ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90682983
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90606079
162RING1B_27294783_Chip-Seq_NPCs_Mouse0.90408002
163TFEB_21752829_ChIP-Seq_HELA_Human0.90346360
164TET1_21490601_ChIP-Seq_MESCs_Mouse0.89558392
165VDR_22108803_ChIP-Seq_LS180_Human0.89557832
166PRDM14_20953172_ChIP-Seq_ESCs_Human0.89237454
167RUNX2_22187159_ChIP-Seq_PCA_Human0.88908862
168POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88691230
169FUS_26573619_Chip-Seq_HEK293_Human0.87807074
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87421195
171ELK1_22589737_ChIP-Seq_MCF10A_Human0.87123809
172UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86114627
173CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86109924
174PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85551634
175KLF4_19829295_ChIP-Seq_ESCs_Human0.84510858
176RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84487234
177SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83626571
178CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82854013
179SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79959602
180SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.78902862
181IGF1R_20145208_ChIP-Seq_DFB_Human0.76692561
182* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76608186
183SOX2_18555785_ChIP-Seq_MESCs_Mouse0.74948135
184CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73244099
185CIITA_25753668_ChIP-Seq_RAJI_Human0.70798389
186CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.69795944
187CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.66667001
188TP63_19390658_ChIP-ChIP_HaCaT_Human0.66597282
189EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.66510170
190DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.66422121
191TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.65271112
192TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.64844837
193TBX5_21415370_ChIP-Seq_HL-1_Mouse0.64688217
194* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.62161522
195GATA4_21415370_ChIP-Seq_HL-1_Mouse0.61972486
196KLF4_18555785_ChIP-Seq_MESCs_Mouse0.61506269
197SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.61296355
198CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.61125220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.89038571
2MP0003880_abnormal_central_pattern4.91345537
3MP0010094_abnormal_chromosome_stability4.45638114
4MP0008058_abnormal_DNA_repair4.27437020
5MP0003693_abnormal_embryo_hatching4.26882758
6MP0003635_abnormal_synaptic_transmissio4.25339089
7MP0003111_abnormal_nucleus_morphology3.86178511
8MP0004957_abnormal_blastocyst_morpholog3.58771404
9MP0009745_abnormal_behavioral_response3.49472288
10MP0002064_seizures3.39099679
11MP0009046_muscle_twitch3.34890640
12MP0004270_analgesia3.33971258
13MP0002063_abnormal_learning/memory/cond3.32310507
14MP0008057_abnormal_DNA_replication3.29866169
15MP0003718_maternal_effect3.20934663
16MP0001968_abnormal_touch/_nociception3.00243320
17MP0003077_abnormal_cell_cycle2.94736866
18MP0008932_abnormal_embryonic_tissue2.94327502
19MP0002822_catalepsy2.91160062
20MP0002572_abnormal_emotion/affect_behav2.81732065
21MP0002272_abnormal_nervous_system2.64347637
22MP0001501_abnormal_sleep_pattern2.56961050
23MP0008007_abnormal_cellular_replicative2.53297778
24MP0009697_abnormal_copulation2.37907106
25MP0005423_abnormal_somatic_nervous2.36926761
26MP0002736_abnormal_nociception_after2.35193765
27MP0001486_abnormal_startle_reflex2.34973473
28MP0002734_abnormal_mechanical_nocicepti2.31903066
29MP0009780_abnormal_chondrocyte_physiolo2.18730740
30MP0003941_abnormal_skin_development2.18351516
31MP0003786_premature_aging2.12425231
32MP0001440_abnormal_grooming_behavior2.11827157
33MP0002909_abnormal_adrenal_gland2.02798947
34MP0005646_abnormal_pituitary_gland1.93079786
35MP0003122_maternal_imprinting1.92133386
36MP0002735_abnormal_chemical_nociception1.89602587
37MP0002067_abnormal_sensory_capabilities1.88469666
38MP0008569_lethality_at_weaning1.87278736
39MP0006035_abnormal_mitochondrial_morpho1.86468398
40MP0002733_abnormal_thermal_nociception1.86181282
41MP0001970_abnormal_pain_threshold1.82447565
42MP0004924_abnormal_behavior1.80991534
43MP0005386_behavior/neurological_phenoty1.80991534
44MP0001730_embryonic_growth_arrest1.77792159
45MP0003787_abnormal_imprinting1.77342382
46MP0003950_abnormal_plasma_membrane1.76172643
47MP0003329_amyloid_beta_deposits1.73715113
48MP0004811_abnormal_neuron_physiology1.72659278
49MP0006036_abnormal_mitochondrial_physio1.70790739
50MP0006292_abnormal_olfactory_placode1.70410748
51MP0004858_abnormal_nervous_system1.67342673
52MP0003890_abnormal_embryonic-extraembry1.61831535
53MP0002102_abnormal_ear_morphology1.59193563
54MP0008789_abnormal_olfactory_epithelium1.58864149
55MP0001293_anophthalmia1.56313598
56MP0000751_myopathy1.52680838
57MP0002557_abnormal_social/conspecific_i1.52520514
58MP0001697_abnormal_embryo_size1.49148139
59MP0006276_abnormal_autonomic_nervous1.48845299
60MP0000350_abnormal_cell_proliferation1.48633356
61MP0002184_abnormal_innervation1.46713379
62MP0003633_abnormal_nervous_system1.44201246
63MP0001672_abnormal_embryogenesis/_devel1.43938275
64MP0005380_embryogenesis_phenotype1.43938275
65MP0000013_abnormal_adipose_tissue1.43525991
66MP0003879_abnormal_hair_cell1.42563218
67MP0000358_abnormal_cell_content/1.39927358
68MP0002066_abnormal_motor_capabilities/c1.39068210
69MP0003123_paternal_imprinting1.38916563
70MP0000955_abnormal_spinal_cord1.38180160
71MP0002837_dystrophic_cardiac_calcinosis1.37114602
72MP0003937_abnormal_limbs/digits/tail_de1.36350240
73MP0002084_abnormal_developmental_patter1.33479664
74MP0001984_abnormal_olfaction1.32100711
75MP0001661_extended_life_span1.28408211
76MP0002938_white_spotting1.27997341
77MP0002085_abnormal_embryonic_tissue1.25861709
78MP0004147_increased_porphyrin_level1.25489686
79MP0000372_irregular_coat_pigmentation1.25021958
80MP0004885_abnormal_endolymph1.24572914
81MP0002882_abnormal_neuron_morphology1.23817791
82MP0001529_abnormal_vocalization1.23441312
83MP0002080_prenatal_lethality1.22996561
84MP0001929_abnormal_gametogenesis1.22863023
85MP0004142_abnormal_muscle_tone1.22733346
86MP0004145_abnormal_muscle_electrophysio1.21881785
87MP0003567_abnormal_fetal_cardiomyocyte1.21572152
88MP0003984_embryonic_growth_retardation1.21381864
89MP0003283_abnormal_digestive_organ1.20541516
90MP0002210_abnormal_sex_determination1.19104088
91MP0000749_muscle_degeneration1.19091514
92MP0005645_abnormal_hypothalamus_physiol1.17964196
93MP0003631_nervous_system_phenotype1.17735740
94MP0002088_abnormal_embryonic_growth/wei1.17621403
95MP0008872_abnormal_physiological_respon1.15639462
96MP0004233_abnormal_muscle_weight1.15592424
97MP0000778_abnormal_nervous_system1.15048231
98MP0010352_gastrointestinal_tract_polyps1.14596718
99MP0002234_abnormal_pharynx_morphology1.12664787
100MP0003806_abnormal_nucleotide_metabolis1.11561115
101MP0008961_abnormal_basal_metabolism1.11007751
102MP0003186_abnormal_redox_activity1.10824719
103MP0010234_abnormal_vibrissa_follicle1.09130221
104MP0002160_abnormal_reproductive_system1.07214428
105MP0001905_abnormal_dopamine_level1.06985715
106MP0009672_abnormal_birth_weight1.03487096
107MP0010030_abnormal_orbit_morphology1.03408357
108MP0003075_altered_response_to1.03246258
109MP0005395_other_phenotype1.03090628
110MP0008874_decreased_physiological_sensi1.02467667
111MP0004215_abnormal_myocardial_fiber1.02408849
112MP0006054_spinal_hemorrhage1.02084457
113MP0003690_abnormal_glial_cell1.00123570
114MP0000569_abnormal_digit_pigmentation0.99445268
115MP0002233_abnormal_nose_morphology0.99302801
116MP0002152_abnormal_brain_morphology0.98985768
117MP0005394_taste/olfaction_phenotype0.98981519
118MP0005499_abnormal_olfactory_system0.98981519
119MP0001502_abnormal_circadian_rhythm0.98637885
120MP0000653_abnormal_sex_gland0.98596340
121MP0000313_abnormal_cell_death0.98572000
122MP0000747_muscle_weakness0.97831110
123MP0001145_abnormal_male_reproductive0.96276880
124MP0004197_abnormal_fetal_growth/weight/0.96225938
125MP0003646_muscle_fatigue0.95450838
126MP0001177_atelectasis0.94617260
127MP0005535_abnormal_body_temperature0.92899165
128MP0001286_abnormal_eye_development0.92714693
129MP0002229_neurodegeneration0.92084813
130MP0003315_abnormal_perineum_morphology0.91770275
131MP0005187_abnormal_penis_morphology0.91626395
132MP0002069_abnormal_eating/drinking_beha0.91494364
133MP0004085_abnormal_heartbeat0.90237604
134MP0010307_abnormal_tumor_latency0.90056753
135MP0006072_abnormal_retinal_apoptosis0.87141514
136MP0005410_abnormal_fertilization0.85981547
137MP0003119_abnormal_digestive_system0.85567590
138MP0005623_abnormal_meninges_morphology0.83792192
139MP0004130_abnormal_muscle_cell0.82513397
140MP0004484_altered_response_of0.82456054
141MP0003755_abnormal_palate_morphology0.81787433
142MP0002396_abnormal_hematopoietic_system0.81695182
143MP0002086_abnormal_extraembryonic_tissu0.81061828
144MP0001119_abnormal_female_reproductive0.80730616
145MP0003385_abnormal_body_wall0.80158163
146MP0000604_amyloidosis0.80013506
147MP0002751_abnormal_autonomic_nervous0.79477161
148MP0003632_abnormal_nervous_system0.79198996
149MP0002697_abnormal_eye_size0.76800469
150MP0004036_abnormal_muscle_relaxation0.75730920
151MP0003121_genomic_imprinting0.74984157
152MP0003634_abnormal_glial_cell0.74892698
153MP0003698_abnormal_male_reproductive0.74882412
154MP0003172_abnormal_lysosome_physiology0.73619418
155MP0002090_abnormal_vision0.72125499
156MP0009250_abnormal_appendicular_skeleto0.71856469
157MP0005551_abnormal_eye_electrophysiolog0.71045173
158MP0003221_abnormal_cardiomyocyte_apopto0.69483711
159MP0005266_abnormal_metabolism0.69304393
160MP0002161_abnormal_fertility/fecundity0.68944402
161MP0008877_abnormal_DNA_methylation0.68908303
162MP0002111_abnormal_tail_morphology0.67939881
163MP0003137_abnormal_impulse_conducting0.66436476
164MP0003699_abnormal_female_reproductive0.65286054
165MP0009703_decreased_birth_body0.64918645
166MP0005167_abnormal_blood-brain_barrier0.64883837
167MP0001299_abnormal_eye_distance/0.64504481
168MP0000049_abnormal_middle_ear0.64412891
169MP0000762_abnormal_tongue_morphology0.63404807
170MP0002269_muscular_atrophy0.62822786
171MP0008775_abnormal_heart_ventricle0.61363529
172MP0008995_early_reproductive_senescence0.60938043
173MP0004084_abnormal_cardiac_muscle0.59695486
174MP0000003_abnormal_adipose_tissue0.58604398
175MP0001188_hyperpigmentation0.58003052
176MP0001943_abnormal_respiration0.57838878
177MP0005620_abnormal_muscle_contractility0.57231404
178MP0001963_abnormal_hearing_physiology0.55626296
179MP0000920_abnormal_myelination0.54466589
180MP0003045_fibrosis0.53660456
181MP0010769_abnormal_survival0.53326659
182MP0004043_abnormal_pH_regulation0.52667749
183MP0003956_abnormal_body_size0.52447760

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.66293183
2Myokymia (HP:0002411)6.36847270
3Focal seizures (HP:0007359)5.79769202
4Visual hallucinations (HP:0002367)5.46542840
5Atonic seizures (HP:0010819)4.68898051
6Epileptic encephalopathy (HP:0200134)4.63352596
7Absence seizures (HP:0002121)4.44194137
8Febrile seizures (HP:0002373)4.33784441
9Progressive cerebellar ataxia (HP:0002073)4.24875731
10Dialeptic seizures (HP:0011146)4.05241758
11Generalized tonic-clonic seizures (HP:0002069)4.04723607
12Chromsome breakage (HP:0040012)3.97645828
13Action tremor (HP:0002345)3.96757604
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.95641862
15Abnormality of the labia minora (HP:0012880)3.70547093
16Impaired vibration sensation in the lower limbs (HP:0002166)3.70503541
17Postural instability (HP:0002172)3.53525566
18Dysdiadochokinesis (HP:0002075)3.50578133
19Depression (HP:0000716)3.43300884
20Papilledema (HP:0001085)3.42168909
21Urinary bladder sphincter dysfunction (HP:0002839)3.31074181
22Poor eye contact (HP:0000817)3.28996856
23Meckel diverticulum (HP:0002245)3.23771443
24Gaze-evoked nystagmus (HP:0000640)3.23722668
25Abnormality of the lower motor neuron (HP:0002366)3.22865002
26Dysmetric saccades (HP:0000641)3.19951300
27Supranuclear gaze palsy (HP:0000605)3.18156235
28Abnormality of glycolysis (HP:0004366)3.17289600
29Abnormal social behavior (HP:0012433)3.15864755
30Impaired social interactions (HP:0000735)3.15864755
31Dysmetria (HP:0001310)3.15347189
32Broad-based gait (HP:0002136)3.13208591
33Abnormality of the ileum (HP:0001549)3.12231023
34Truncal ataxia (HP:0002078)3.11992334
35Ankle clonus (HP:0011448)3.11092632
36Abnormality of chromosome stability (HP:0003220)3.08726881
37Increased serum pyruvate (HP:0003542)3.07186745
38Colon cancer (HP:0003003)3.06598781
39Abnormality of the preputium (HP:0100587)2.99089315
40Anxiety (HP:0000739)2.98994083
41Impaired smooth pursuit (HP:0007772)2.96561263
42Hyperventilation (HP:0002883)2.95702841
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.94929809
44Birth length less than 3rd percentile (HP:0003561)2.93345720
45Urinary urgency (HP:0000012)2.91598654
46Hemiplegia (HP:0002301)2.90243502
47Abnormal eating behavior (HP:0100738)2.86374870
48Genetic anticipation (HP:0003743)2.84122895
49Ventricular fibrillation (HP:0001663)2.83626665
50Ependymoma (HP:0002888)2.83113545
51Acute necrotizing encephalopathy (HP:0006965)2.76194517
52Bradykinesia (HP:0002067)2.76065309
53Acute encephalopathy (HP:0006846)2.73048684
54Amblyopia (HP:0000646)2.65775670
55Abnormal lung lobation (HP:0002101)2.65039083
56Status epilepticus (HP:0002133)2.63023232
57Resting tremor (HP:0002322)2.61596708
58Abnormality of ocular smooth pursuit (HP:0000617)2.61197779
59Small intestinal stenosis (HP:0012848)2.57830187
60Duodenal stenosis (HP:0100867)2.57830187
61Abnormality of methionine metabolism (HP:0010901)2.55312398
62Pheochromocytoma (HP:0002666)2.52530292
63Abnormal mitochondria in muscle tissue (HP:0008316)2.49865601
64Scanning speech (HP:0002168)2.49542921
65Spastic gait (HP:0002064)2.46797995
66Increased CSF lactate (HP:0002490)2.44263900
67Drooling (HP:0002307)2.43883576
68Excessive salivation (HP:0003781)2.43883576
69Impaired vibratory sensation (HP:0002495)2.43470054
70Microvesicular hepatic steatosis (HP:0001414)2.43094494
71Intention tremor (HP:0002080)2.43016423
72Mutism (HP:0002300)2.42124672
73Hemiparesis (HP:0001269)2.39553914
74Methylmalonic acidemia (HP:0002912)2.38965416
75Epileptiform EEG discharges (HP:0011182)2.38859881
76Increased serum lactate (HP:0002151)2.36928813
77Termporal pattern (HP:0011008)2.36221882
78Insidious onset (HP:0003587)2.36221882
79Nemaline bodies (HP:0003798)2.36075627
80Bundle branch block (HP:0011710)2.30361403
81EEG with generalized epileptiform discharges (HP:0011198)2.27554567
82Nephroblastoma (Wilms tumor) (HP:0002667)2.24918772
83Torticollis (HP:0000473)2.24704227
84Type I transferrin isoform profile (HP:0003642)2.22860040
85Progressive inability to walk (HP:0002505)2.21116566
86Abnormality of binocular vision (HP:0011514)2.21009797
87Diplopia (HP:0000651)2.21009797
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20110398
89Abnormality of alanine metabolism (HP:0010916)2.20110398
90Hyperalaninemia (HP:0003348)2.20110398
91Abnormality of the duodenum (HP:0002246)2.19470382
92Lower limb muscle weakness (HP:0007340)2.19221622
93Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.17728149
94Muscle fiber inclusion bodies (HP:0100299)2.17067494
95Hypsarrhythmia (HP:0002521)2.16806631
96Embryonal renal neoplasm (HP:0011794)2.15488245
97Pointed chin (HP:0000307)2.14636184
98Abnormality of serum amino acid levels (HP:0003112)2.13853706
99Exercise-induced muscle cramps (HP:0003710)2.12770029
100Generalized myoclonic seizures (HP:0002123)2.12341894
101Focal dystonia (HP:0004373)2.11672065
102Progressive macrocephaly (HP:0004481)2.11231231
103Cerebral hypomyelination (HP:0006808)2.11169043
104Stereotypic behavior (HP:0000733)2.11132523
105Astrocytoma (HP:0009592)2.10807504
106Abnormality of the astrocytes (HP:0100707)2.10807504
107Degeneration of anterior horn cells (HP:0002398)2.09624590
108Abnormality of the anterior horn cell (HP:0006802)2.09624590
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08795082
110Abnormal protein N-linked glycosylation (HP:0012347)2.08795082
111Abnormal protein glycosylation (HP:0012346)2.08795082
112Abnormal glycosylation (HP:0012345)2.08795082
113Neuroendocrine neoplasm (HP:0100634)2.07874867
114Cerebral inclusion bodies (HP:0100314)2.07764065
115Sloping forehead (HP:0000340)2.07666027
116Hepatic necrosis (HP:0002605)2.06840824
117Myelodysplasia (HP:0002863)2.06128503
118Pancreatic islet-cell hyperplasia (HP:0004510)2.05970873
119Fetal akinesia sequence (HP:0001989)2.05699361
120Ankyloglossia (HP:0010296)2.04100237
121Hepatocellular necrosis (HP:0001404)2.03639930
122Gait ataxia (HP:0002066)2.03430564
123Failure to thrive in infancy (HP:0001531)2.02299207
124Glioma (HP:0009733)2.00828037
125Abnormality of the carotid arteries (HP:0005344)2.00732748
126Cerebral edema (HP:0002181)2.00728000
127Mitochondrial inheritance (HP:0001427)2.00415876
128Hypoventilation (HP:0002791)1.98808311
129Rigidity (HP:0002063)1.98618394
130Supernumerary spleens (HP:0009799)1.98578825
131Abnormality of homocysteine metabolism (HP:0010919)1.98451551
132Homocystinuria (HP:0002156)1.98451551
133Horseshoe kidney (HP:0000085)1.97368722
134Volvulus (HP:0002580)1.97233483
135Insomnia (HP:0100785)1.96997039
136Increased hepatocellular lipid droplets (HP:0006565)1.96010260
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95778539
138Neoplasm of the peripheral nervous system (HP:0100007)1.95478568
139Lower limb amyotrophy (HP:0007210)1.95244151
140Progressive muscle weakness (HP:0003323)1.95128247
141Megaloblastic anemia (HP:0001889)1.95089640
142Absent speech (HP:0001344)1.94378722
143Rhabdomyosarcoma (HP:0002859)1.94223523
144Abnormality of saccadic eye movements (HP:0000570)1.93905517
145Abnormal EKG (HP:0003115)1.93099803
146Annular pancreas (HP:0001734)1.92665562
147Reduced antithrombin III activity (HP:0001976)1.92584358
148Premature ovarian failure (HP:0008209)1.91844745
149Lactic acidosis (HP:0003128)1.91477239
150Megalencephaly (HP:0001355)1.90693936
151Tetraplegia (HP:0002445)1.89832458
152Hyperglycinemia (HP:0002154)1.88956428
153Methylmalonic aciduria (HP:0012120)1.88900633
154Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.88798900
155Rapidly progressive (HP:0003678)1.88403698
156Multiple enchondromatosis (HP:0005701)1.87804731
157Incomplete penetrance (HP:0003829)1.86591524
158Triphalangeal thumb (HP:0001199)1.85753952
159Exercise-induced myalgia (HP:0003738)1.85483009
160Absent radius (HP:0003974)1.85398349
161Clonus (HP:0002169)1.85354508
162Ectopic kidney (HP:0000086)1.83766527
163Shoulder girdle muscle weakness (HP:0003547)1.83497570
164Psychosis (HP:0000709)1.82081634
165Craniofacial dystonia (HP:0012179)1.81702690
166Blue irides (HP:0000635)1.81349520
167Exercise intolerance (HP:0003546)1.81229466
168Impaired pain sensation (HP:0007328)1.80926345
169Abnormality of pain sensation (HP:0010832)1.80926345
1703-Methylglutaconic aciduria (HP:0003535)1.80729040
171Secondary amenorrhea (HP:0000869)1.80442455
172Medulloblastoma (HP:0002885)1.78255694
173Bifid tongue (HP:0010297)1.78246676
174Neoplasm of the colon (HP:0100273)1.78042702
175Abnormality of the corticospinal tract (HP:0002492)1.77375415
176Aplasia involving forearm bones (HP:0009822)1.77041302
177Absent forearm bone (HP:0003953)1.77041302
178Sensory axonal neuropathy (HP:0003390)1.76435508
179Achilles tendon contracture (HP:0001771)1.75839585
180Delusions (HP:0000746)1.75149896
181Increased nuchal translucency (HP:0010880)1.75095394
182Menstrual irregularities (HP:0000858)1.75050338
183Neuronal loss in central nervous system (HP:0002529)1.74964545
184Macroorchidism (HP:0000053)1.74221328
185Hypoglycemic coma (HP:0001325)1.70385344
186Lipid accumulation in hepatocytes (HP:0006561)1.70199075
187Hypoplasia of the pons (HP:0012110)1.69686414
188Absent thumb (HP:0009777)1.68994095
189CNS hypomyelination (HP:0003429)1.67594823
190Aplastic anemia (HP:0001915)1.67341900
191Abnormality of the pons (HP:0007361)1.66712392
192Neoplasm of the adrenal gland (HP:0100631)1.66476567
193Abnormal umbilical cord blood vessels (HP:0011403)1.65849435
194Single umbilical artery (HP:0001195)1.65849435
195Abnormality of the fetal cardiovascular system (HP:0010948)1.65849435
196Clubbing of toes (HP:0100760)1.63581726
197Abnormality of sulfur amino acid metabolism (HP:0004339)1.63271876
198Abnormality of glycine metabolism (HP:0010895)1.61889056
199Abnormality of serine family amino acid metabolism (HP:0010894)1.61889056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.85023049
2MAP3K94.27816872
3BUB13.92774176
4EPHA43.92753931
5CDC73.26148493
6SRPK13.18645764
7MAP3K43.15383826
8EIF2AK33.09592369
9EIF2AK13.05132909
10TTK3.04770576
11VRK22.66782938
12MINK12.60604749
13MAP3K122.59563011
14STK162.55093350
15TRIM282.55078156
16PLK32.51896372
17PBK2.42656373
18KSR22.40570119
19PAK62.29275626
20DAPK22.21287734
21MAP2K72.19054640
22MAP2K42.18695640
23PRKD32.12520865
24NUAK12.12444123
25BRSK22.09566619
26MKNK12.08528118
27PLK42.06753468
28RIPK42.04341950
29MST42.04247060
30MKNK22.04224317
31CAMKK11.99289724
32NTRK11.88369472
33ZAK1.85434236
34NTRK21.78343452
35WEE11.73850625
36PLK11.70073803
37STK381.66275729
38DAPK11.66189070
39KSR11.65288528
40MAP3K131.61912212
41PLK21.55257042
42ARAF1.51604397
43PNCK1.49826556
44CDK191.49682789
45PDK21.43525176
46CDK51.42980131
47VRK11.41821372
48BMPR1B1.35707387
49ATR1.33821095
50MARK11.30762386
51NEK11.30647168
52CHEK21.30094960
53WNK31.23264584
54PRKCG1.22968120
55GRK51.21555923
56MAP4K21.18396911
57FES1.16767968
58TYRO31.15975860
59NEK21.15480546
60BCR1.13333277
61OBSCN1.12793116
62CAMKK21.11806095
63ALK1.09485014
64MAP3K21.08292179
65LATS21.07742791
66AURKB1.05661006
67TAOK11.04770115
68PRPF4B1.04251978
69CHEK11.02533507
70TNK21.00462743
71BCKDK0.99586921
72EIF2AK20.99044550
73SIK20.98438779
74PRKCH0.96610749
75CAMK10.96577949
76PINK10.96251298
77ATM0.93602111
78CSNK1G10.93277388
79PAK30.93158637
80LMTK20.92913460
81RAF10.92284706
82UHMK10.91223772
83CAMK2A0.90466221
84CSNK1G30.90119626
85STK110.89600031
86RET0.89568242
87PDK10.89260855
88SGK30.88023770
89CDK180.86972441
90ERBB30.86642917
91TAF10.86312877
92CLK10.86031716
93CDK150.85362622
94SGK20.84981342
95MAP3K10.82321703
96CDK140.82291473
97CDK70.81707608
98SGK4940.80229416
99SGK2230.80229416
100PHKG10.79886950
101PHKG20.79886950
102CAMK1G0.79231221
103STK30.78202013
104CASK0.78200699
105ERBB40.78080437
106PDPK10.77089894
107PRKCI0.76625436
108SCYL20.75690962
109AURKA0.74645424
110CSNK1A1L0.73081797
111PDK30.72867452
112PDK40.72867452
113CDK11A0.72464028
114MAP3K70.71907896
115SGK10.71861059
116BRSK10.69648016
117CDK90.69292665
118PTK2B0.67483196
119STK38L0.67366963
120BRAF0.66925101
121RIPK10.66301964
122CSNK1G20.65456235
123CAMK2B0.64699329
124FER0.61872752
125NME10.61693336
126CCNB10.59665814
127LIMK10.58725958
128NEK60.58169628
129CSNK1E0.57717963
130INSRR0.57133990
131CDC42BPA0.57073315
132RPS6KA30.56512657
133OXSR10.56341963
134BMPR20.55900546
135CSNK2A20.55046715
136MAPK130.54706497
137MAPKAPK50.54110839
138CDK20.53495914
139CDK10.53085135
140NME20.52633095
141AKT30.52447272
142MAPK100.52391692
143CSNK2A10.50701623
144PASK0.49452624
145WNK10.49412167
146TGFBR10.47816840
147FGFR20.47649500
148CAMK2D0.45772127
149CDK80.45753712
150STK390.45731951
151CAMK40.44815417
152TIE10.44665743
153PDGFRA0.44515329
154CAMK2G0.44116699
155DMPK0.43599613
156TNIK0.43561565
157DYRK20.43171965
158BRD40.40321324
159MAP2K10.40077634
160DYRK1A0.39987521
161PRKDC0.39512869
162LATS10.38413814
163CAMK1D0.37413746
164MAP3K80.36947924
165SIK30.36924748
166MET0.36359433
167MAP3K50.35695444
168WNK40.35389947
169TSSK60.35103861
170FYN0.33605850
171PAK20.32988356
172PRKCB0.32813966
173FGFR10.32231725
174DAPK30.32100414
175PAK10.29848599
176FLT30.28568918
177GRK10.26909380
178STK40.26457825
179RPS6KB20.25928651
180AKT20.25817629

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.66885827
2Proteasome_Homo sapiens_hsa030503.46280048
3Synaptic vesicle cycle_Homo sapiens_hsa047213.40342914
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37199744
5Mismatch repair_Homo sapiens_hsa034303.35811146
6DNA replication_Homo sapiens_hsa030303.33023848
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.29985346
8Non-homologous end-joining_Homo sapiens_hsa034503.01860932
9Long-term potentiation_Homo sapiens_hsa047202.74256640
10GABAergic synapse_Homo sapiens_hsa047272.72022678
11Olfactory transduction_Homo sapiens_hsa047402.71815381
12Circadian entrainment_Homo sapiens_hsa047132.58857708
13Homologous recombination_Homo sapiens_hsa034402.54832374
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54416762
15RNA polymerase_Homo sapiens_hsa030202.54258901
16Amphetamine addiction_Homo sapiens_hsa050312.46213420
17Protein export_Homo sapiens_hsa030602.46104937
18RNA transport_Homo sapiens_hsa030132.42508969
19Glutamatergic synapse_Homo sapiens_hsa047242.38760970
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.37687477
21Morphine addiction_Homo sapiens_hsa050322.36962514
22One carbon pool by folate_Homo sapiens_hsa006702.32123352
23Fanconi anemia pathway_Homo sapiens_hsa034602.31085350
24Nucleotide excision repair_Homo sapiens_hsa034202.29745288
25Base excision repair_Homo sapiens_hsa034102.18294235
26Spliceosome_Homo sapiens_hsa030402.18135499
27Basal transcription factors_Homo sapiens_hsa030222.16776358
28Salivary secretion_Homo sapiens_hsa049702.15809749
29Cell cycle_Homo sapiens_hsa041102.12965215
30Dopaminergic synapse_Homo sapiens_hsa047282.07718492
31Insulin secretion_Homo sapiens_hsa049112.05128333
32RNA degradation_Homo sapiens_hsa030181.98919789
33Propanoate metabolism_Homo sapiens_hsa006401.98053534
34Gastric acid secretion_Homo sapiens_hsa049711.95661403
35Nitrogen metabolism_Homo sapiens_hsa009101.92756631
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85079742
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.81948688
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81641831
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70313560
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70171236
41Cholinergic synapse_Homo sapiens_hsa047251.69633113
42Pyrimidine metabolism_Homo sapiens_hsa002401.69619382
43Renin secretion_Homo sapiens_hsa049241.66161601
44Selenocompound metabolism_Homo sapiens_hsa004501.64876668
45Oxytocin signaling pathway_Homo sapiens_hsa049211.63542537
46Pyruvate metabolism_Homo sapiens_hsa006201.63502096
47Long-term depression_Homo sapiens_hsa047301.60671132
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60279129
49Calcium signaling pathway_Homo sapiens_hsa040201.57950064
50Taste transduction_Homo sapiens_hsa047421.56582006
51Cocaine addiction_Homo sapiens_hsa050301.55176119
52Collecting duct acid secretion_Homo sapiens_hsa049661.53080977
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50779318
54Steroid biosynthesis_Homo sapiens_hsa001001.49616506
55Fatty acid elongation_Homo sapiens_hsa000621.48352402
56GnRH signaling pathway_Homo sapiens_hsa049121.44788599
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42874618
58Serotonergic synapse_Homo sapiens_hsa047261.40545520
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37779375
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37489564
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36167376
62Purine metabolism_Homo sapiens_hsa002301.32801864
63Parkinsons disease_Homo sapiens_hsa050121.31891483
64Biosynthesis of amino acids_Homo sapiens_hsa012301.31636371
65Carbon metabolism_Homo sapiens_hsa012001.31288910
66Gap junction_Homo sapiens_hsa045401.30864069
67Ribosome_Homo sapiens_hsa030101.26469343
68Oxidative phosphorylation_Homo sapiens_hsa001901.24981745
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24552515
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24416232
71Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22241365
72Type II diabetes mellitus_Homo sapiens_hsa049301.21878101
73mRNA surveillance pathway_Homo sapiens_hsa030151.21849378
74Glioma_Homo sapiens_hsa052141.20867309
75cAMP signaling pathway_Homo sapiens_hsa040241.20489977
76Vitamin B6 metabolism_Homo sapiens_hsa007501.18424408
77Estrogen signaling pathway_Homo sapiens_hsa049151.18257596
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15971079
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09085838
80p53 signaling pathway_Homo sapiens_hsa041151.07332713
81Huntingtons disease_Homo sapiens_hsa050161.06422241
82Vibrio cholerae infection_Homo sapiens_hsa051101.06050183
83Oocyte meiosis_Homo sapiens_hsa041141.05418026
84cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02093712
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01976039
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00864680
87Cardiac muscle contraction_Homo sapiens_hsa042600.97591598
88ErbB signaling pathway_Homo sapiens_hsa040120.97113338
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96841612
90Dorso-ventral axis formation_Homo sapiens_hsa043200.96105174
91Melanogenesis_Homo sapiens_hsa049160.92276770
92Dilated cardiomyopathy_Homo sapiens_hsa054140.89552067
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87679422
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87142226
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.86976026
96Thyroid hormone synthesis_Homo sapiens_hsa049180.86845276
97Glucagon signaling pathway_Homo sapiens_hsa049220.83864724
98Butanoate metabolism_Homo sapiens_hsa006500.83774833
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83359995
100Pancreatic secretion_Homo sapiens_hsa049720.81123090
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79867354
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77775009
103mTOR signaling pathway_Homo sapiens_hsa041500.77219876
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.75490095
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74782001
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74759130
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73515231
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72867022
109Fatty acid metabolism_Homo sapiens_hsa012120.68326829
110Sulfur relay system_Homo sapiens_hsa041220.68249551
111MAPK signaling pathway_Homo sapiens_hsa040100.67334135
112Folate biosynthesis_Homo sapiens_hsa007900.66419315
113Arginine biosynthesis_Homo sapiens_hsa002200.66174015
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65929619
115Pentose phosphate pathway_Homo sapiens_hsa000300.64280031
116Arginine and proline metabolism_Homo sapiens_hsa003300.63327231
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.63154016
118Inositol phosphate metabolism_Homo sapiens_hsa005620.63012570
119Alzheimers disease_Homo sapiens_hsa050100.62924253
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62873177
121Type I diabetes mellitus_Homo sapiens_hsa049400.62538454
122Choline metabolism in cancer_Homo sapiens_hsa052310.62179154
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61907442
124Metabolic pathways_Homo sapiens_hsa011000.61617914
125Glutathione metabolism_Homo sapiens_hsa004800.60456708
126Bile secretion_Homo sapiens_hsa049760.60095826
127Axon guidance_Homo sapiens_hsa043600.59945821
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59756075
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59706900
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58172687
131Sulfur metabolism_Homo sapiens_hsa009200.56898745
132Insulin signaling pathway_Homo sapiens_hsa049100.56606617
133VEGF signaling pathway_Homo sapiens_hsa043700.54065881
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53682106
135Lysine degradation_Homo sapiens_hsa003100.52759252
136Prion diseases_Homo sapiens_hsa050200.48926779
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47689826
138TGF-beta signaling pathway_Homo sapiens_hsa043500.47217982
139Non-small cell lung cancer_Homo sapiens_hsa052230.46914549
140Rap1 signaling pathway_Homo sapiens_hsa040150.45953206
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45709449
142Circadian rhythm_Homo sapiens_hsa047100.44677601
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44333745
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44322140
145Thyroid cancer_Homo sapiens_hsa052160.43351741
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.42679391
147N-Glycan biosynthesis_Homo sapiens_hsa005100.42391109
148beta-Alanine metabolism_Homo sapiens_hsa004100.42070870
149Endocytosis_Homo sapiens_hsa041440.41282745
150Ras signaling pathway_Homo sapiens_hsa040140.40935082
151Hippo signaling pathway_Homo sapiens_hsa043900.40627988
152Fatty acid degradation_Homo sapiens_hsa000710.40407059
153Peroxisome_Homo sapiens_hsa041460.39903443
154Alcoholism_Homo sapiens_hsa050340.36748123
155Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36483298
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.36361217
157Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35054818
158Phototransduction_Homo sapiens_hsa047440.33836337
159Renal cell carcinoma_Homo sapiens_hsa052110.32188447
160Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31939877
161Endometrial cancer_Homo sapiens_hsa052130.31639683
162Fatty acid biosynthesis_Homo sapiens_hsa000610.30399870
163Regulation of autophagy_Homo sapiens_hsa041400.27621781
164African trypanosomiasis_Homo sapiens_hsa051430.26841765
165HIF-1 signaling pathway_Homo sapiens_hsa040660.25493478
166Wnt signaling pathway_Homo sapiens_hsa043100.24794772
167Caffeine metabolism_Homo sapiens_hsa002320.23184204
168Epstein-Barr virus infection_Homo sapiens_hsa051690.23107325
169Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.22024166
170Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21901391
171Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21335922
172Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20812402
173Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20644661
174Glycerophospholipid metabolism_Homo sapiens_hsa005640.20288311
175Fructose and mannose metabolism_Homo sapiens_hsa000510.17755110
176Basal cell carcinoma_Homo sapiens_hsa052170.15880517
177Vitamin digestion and absorption_Homo sapiens_hsa049770.15794250
178Tight junction_Homo sapiens_hsa045300.15548641
179Adherens junction_Homo sapiens_hsa045200.14030413
180Tryptophan metabolism_Homo sapiens_hsa003800.13481977
181Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12199231
182Drug metabolism - other enzymes_Homo sapiens_hsa009830.10156318
183Hedgehog signaling pathway_Homo sapiens_hsa043400.09800565
184MicroRNAs in cancer_Homo sapiens_hsa052060.08295349
185Viral carcinogenesis_Homo sapiens_hsa052030.07909328

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