ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sodium-independent organic anion transport (GO:0043252)	9.94584964
2	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	9.20953815
3	short-chain fatty acid metabolic process (GO:0046459)	8.92053419
4	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	8.84803413
5	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	8.84803413
6	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	8.64548302
7	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	8.17796063
8	actin filament depolymerization (GO:0030042)	8.13231247
9	cellular response to hepatocyte growth factor stimulus (GO:0035729)	8.06242059
10	response to hepatocyte growth factor (GO:0035728)	8.06242059
11	lung vasculature development (GO:0060426)	8.00846304
12	mast cell activation involved in immune response (GO:0002279)	7.68424914
13	mast cell degranulation (GO:0043303)	7.68424914
14	lung lobe morphogenesis (GO:0060463)	7.54719884
15	muscle organ morphogenesis (GO:0048644)	7.50942208
16	positive regulation of astrocyte differentiation (GO:0048711)	6.91553706
17	tyrosine phosphorylation of STAT protein (GO:0007260)	6.84194712
18	icosanoid transport (GO:0071715)	6.59244646
19	fatty acid derivative transport (GO:1901571)	6.59244646
20	positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)	6.23338917
21	fibroblast migration (GO:0010761)	6.03124701
22	positive regulation of metanephros development (GO:0072216)	5.97906281
23	vesicle transport along microtubule (GO:0047496)	5.91465185
24	negative regulation of meiosis (GO:0045835)	5.57586690
25	positive regulation of macrophage differentiation (GO:0045651)	5.53872255
26	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.45863226
27	positive regulation of translational initiation (GO:0045948)	5.37145081
28	positive regulation of protein kinase C signaling (GO:0090037)	5.32588830
29	phosphatidylethanolamine metabolic process (GO:0046337)	5.19488861
30	benzene-containing compound metabolic process (GO:0042537)	5.10134096
31	trophoblast giant cell differentiation (GO:0060707)	4.71950189
32	regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)	4.68657879
33	auditory receptor cell differentiation (GO:0042491)	4.65570252
34	regulation of actin nucleation (GO:0051125)	4.64784302
35	negative regulation of catenin import into nucleus (GO:0035414)	4.60661479
36	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	4.51724669
37	mast cell activation (GO:0045576)	4.49829823
38	water-soluble vitamin biosynthetic process (GO:0042364)	4.48466644
39	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.43352895
40	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	4.37261775
41	transepithelial transport (GO:0070633)	4.36813926
42	melanin biosynthetic process (GO:0042438)	4.22103523
43	regulation of protein kinase A signaling (GO:0010738)	4.15772101
44	negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)	4.04877308
45	aerobic respiration (GO:0009060)	3.91633506
46	melanin metabolic process (GO:0006582)	3.89992524
47	negative regulation of smooth muscle cell migration (GO:0014912)	3.89448669
48	lysosome localization (GO:0032418)	3.88158871
49	galactose metabolic process (GO:0006012)	3.86552881
50	myelin assembly (GO:0032288)	3.75919306
51	secondary metabolite biosynthetic process (GO:0044550)	3.72731450
52	monoubiquitinated protein deubiquitination (GO:0035520)	3.70620031
53	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	3.69718343
54	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	3.68068493
55	serotonin receptor signaling pathway (GO:0007210)	3.61604351
56	phosphatidylcholine biosynthetic process (GO:0006656)	3.60935376
57	positive regulation of histone acetylation (GO:0035066)	3.59169123
58	regulation of ARF GTPase activity (GO:0032312)	3.56331679
59	regulation of metanephros development (GO:0072215)	3.51362594
60	single strand break repair (GO:0000012)	3.47938676
61	inflammatory response to antigenic stimulus (GO:0002437)	3.47396112
62	negative regulation of meiotic cell cycle (GO:0051447)	3.46536832
63	regulation of macrophage differentiation (GO:0045649)	3.44486142
64	phasic smooth muscle contraction (GO:0014821)	3.40556638
65	cellular extravasation (GO:0045123)	3.36068381
66	UV protection (GO:0009650)	3.35449369
67	negative regulation of leukocyte chemotaxis (GO:0002689)	3.30198161
68	positive regulation of peptidyl-lysine acetylation (GO:2000758)	3.27196576
69	positive regulation of protein acetylation (GO:1901985)	3.27196576
70	leukocyte degranulation (GO:0043299)	3.24381378
71	positive regulation of myoblast differentiation (GO:0045663)	3.22465468
72	autophagic vacuole assembly (GO:0000045)	3.21422447
73	digestion (GO:0007586)	3.21093189
74	negative regulation of nitric-oxide synthase activity (GO:0051001)	3.19431908
75	excretion (GO:0007588)	3.15159299
76	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.15148334
77	phosphatidylinositol phosphorylation (GO:0046854)	3.12503293
78	protein depolymerization (GO:0051261)	3.08676792
79	galactose catabolic process (GO:0019388)	3.07587334
80	cellular response to heat (GO:0034605)	3.04469682
81	negative regulation of JUN kinase activity (GO:0043508)	3.04282189
82	activation of Rho GTPase activity (GO:0032862)	3.01225513
83	piRNA metabolic process (GO:0034587)	2.96740520
84	regulation of lamellipodium organization (GO:1902743)	2.85859336
85	endocytic recycling (GO:0032456)	2.81562011
86	regulation of protein kinase C signaling (GO:0090036)	2.80656182
87	folic acid transport (GO:0015884)	2.74823100
88	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.74437911
89	decidualization (GO:0046697)	2.70078181
90	hair cell differentiation (GO:0035315)	2.63558408
91	cytokine biosynthetic process (GO:0042089)	2.63287566
92	cellular respiration (GO:0045333)	2.60607917
93	photoreceptor cell maintenance (GO:0045494)	2.60142773
94	positive regulation of calcium ion import (GO:0090280)	2.59169303
95	actin filament polymerization (GO:0030041)	2.57320277
96	regulation of mononuclear cell migration (GO:0071675)	2.54989603
97	intraciliary transport (GO:0042073)	2.54710419
98	lipid phosphorylation (GO:0046834)	2.53520713
99	activation of Ras GTPase activity (GO:0032856)	2.52603507
100	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	2.51948051

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.64434754
2	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	4.42880739
3	ESR1_21235772_ChIP-Seq_MCF-7_Human	3.46482842
4	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.45569472
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.20278824
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.05598686
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.66527927
8	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.55164244
9	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.52735994
10	EP300_21415370_ChIP-Seq_HL-1_Mouse	2.20267033
11	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.18170871
12	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.12457237
13	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.07194570
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.06779578
15	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.99480269
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94645780
17	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.74848833
18	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.74626400
19	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.74160765
20	AHR_22903824_ChIP-Seq_MCF-7_Human	1.73112938
21	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.68798964
22	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.64634871
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.63595287
24	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.48662904
25	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.47906270
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.44004737
27	GATA6_25053715_ChIP-Seq_YYC3_Human	1.43571475
28	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.42862900
29	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.40209870
30	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.40103445
31	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.39259822
32	TP53_16413492_ChIP-PET_HCT116_Human	1.38861050
33	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.38188704
34	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.36988551
35	ERA_21632823_ChIP-Seq_H3396_Human	1.32014383
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.31903480
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29992991
38	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27179081
39	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.26005343
40	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22841328
41	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.20722216
42	FUS_26573619_Chip-Seq_HEK293_Human	1.20060763
43	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.19535555
44	SOX2_20726797_ChIP-Seq_SW620_Human	1.15841288
45	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.15277806
46	GF1B_26923725_Chip-Seq_HPCs_Mouse	1.14344706
47	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.14064409
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.13637482
49	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11017661
50	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.10419517
51	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09879555
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.09879555
53	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.09788046
54	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.08612101
55	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.08073226
56	GATA4_25053715_ChIP-Seq_YYC3_Human	1.07714020
57	CJUN_26792858_Chip-Seq_BT549_Human	1.06867883
58	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.06503323
59	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.05566355
60	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05447293
61	P300_19829295_ChIP-Seq_ESCs_Human	1.05013831
62	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.03828079
63	GBX2_23144817_ChIP-Seq_PC3_Human	1.03210721
64	PHF8_20622853_ChIP-Seq_HELA_Human	1.03167226
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03112982
66	TCF4_23295773_ChIP-Seq_U87_Human	1.02160137
67	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.01679195
68	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.01303555
69	CDX2_22108803_ChIP-Seq_LS180_Human	1.00609683
70	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.00389237
71	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.99044926
72	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.98664904
73	NFYB_21822215_ChIP-Seq_K562_Human	0.98540413
74	P300_18555785_Chip-Seq_ESCs_Mouse	0.98069812
75	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.97670776
76	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.96858881
77	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.95946603
78	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.94261031
79	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.94015678
80	KLF4_18555785_Chip-Seq_ESCs_Mouse	0.93256120
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.91453379
82	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.91050283
83	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.90069213
84	RXR_22108803_ChIP-Seq_LS180_Human	0.88992564
85	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.88389661
86	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.88240318
87	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.88234944
88	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.88180399
89	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86918269
90	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.86918269
91	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.86899770
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.86722666
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.86250952
94	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.85618105
95	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.85282588
96	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.84567508
97	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.84342510
98	P53_22387025_ChIP-Seq_ESCs_Mouse	0.83540744
99	VDR_24787735_ChIP-Seq_THP-1_Human	0.83514124
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.83398625

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	8.26886582
2	MP0003300_gastrointestinal_ulcer	5.99399565
3	MP0005409_darkened_coat_color	5.83721964
4	MP0001756_abnormal_urination	4.85227894
5	MP0009840_abnormal_foam_cell	4.70162438
6	MP0001188_hyperpigmentation	4.37261986
7	MP0005174_abnormal_tail_pigmentation	3.68662396
8	MP0004233_abnormal_muscle_weight	3.27443987
9	MP0000015_abnormal_ear_pigmentation	3.20560064
10	MP0002163_abnormal_gland_morphology	3.18500610
11	MP0004381_abnormal_hair_follicle	2.65582539
12	MP0003866_abnormal_defecation	2.59665696
13	MP0002396_abnormal_hematopoietic_system	2.31956303
14	MP0005023_abnormal_wound_healing	2.09383521
15	MP0003252_abnormal_bile_duct	1.97589331
16	MP0002132_abnormal_respiratory_system	1.97041395
17	MP0005379_endocrine/exocrine_gland_phen	1.92134744
18	MP0008875_abnormal_xenobiotic_pharmacok	1.89296992
19	MP0004272_abnormal_basement_membrane	1.88699346
20	MP0000749_muscle_degeneration	1.81631234
21	MP0010386_abnormal_urinary_bladder	1.73945321
22	MP0003646_muscle_fatigue	1.70993668
23	MP0001968_abnormal_touch/_nociception	1.66048185
24	MP0005084_abnormal_gallbladder_morpholo	1.61747076
25	MP0003638_abnormal_response/metabolism_	1.56150940
26	MP0001727_abnormal_embryo_implantation	1.55618703
27	MP0002095_abnormal_skin_pigmentation	1.55617919
28	MP0002277_abnormal_respiratory_mucosa	1.52294206
29	MP0008058_abnormal_DNA_repair	1.38586334
30	MP0001881_abnormal_mammary_gland	1.27730562
31	MP0005220_abnormal_exocrine_pancreas	1.27609612
32	MP0004808_abnormal_hematopoietic_stem	1.26616432
33	MP0003890_abnormal_embryonic-extraembry	1.22465227
34	MP0005166_decreased_susceptibility_to	1.17467782
35	MP0003878_abnormal_ear_physiology	1.16043174
36	MP0005377_hearing/vestibular/ear_phenot	1.16043174
37	MP0002928_abnormal_bile_duct	1.14150307
38	MP0001270_distended_abdomen	1.11968749
39	MP0009764_decreased_sensitivity_to	1.10396271
40	MP0000462_abnormal_digestive_system	1.06378838
41	MP0004885_abnormal_endolymph	1.03391395
42	MP0002136_abnormal_kidney_physiology	0.97335120
43	MP0001664_abnormal_digestion	0.95374881
44	MP0002138_abnormal_hepatobiliary_system	0.95116326
45	MP0001944_abnormal_pancreas_morphology	0.94720996
46	MP0004134_abnormal_chest_morphology	0.93887534
47	MP0001485_abnormal_pinna_reflex	0.91007421
48	MP0008872_abnormal_physiological_respon	0.90962288
49	MP0009643_abnormal_urine_homeostasis	0.90140804
50	MP0001666_abnormal_nutrient_absorption	0.88258408
51	MP0002135_abnormal_kidney_morphology	0.87346186
52	MP0000343_altered_response_to	0.86775143
53	MP0005365_abnormal_bile_salt	0.85467578
54	MP0001984_abnormal_olfaction	0.80335727
55	MP0003942_abnormal_urinary_system	0.78546609
56	MP0009780_abnormal_chondrocyte_physiolo	0.75778597
57	MP0004133_heterotaxia	0.75163342
58	MP0005171_absent_coat_pigmentation	0.74330441
59	MP0002876_abnormal_thyroid_physiology	0.72801699
60	MP0002269_muscular_atrophy	0.69956032
61	MP0005410_abnormal_fertilization	0.64231113
62	MP0002069_abnormal_eating/drinking_beha	0.61532169
63	MP0005195_abnormal_posterior_eye	0.60970207
64	MP0006138_congestive_heart_failure	0.58405694
65	MP0009765_abnormal_xenobiotic_induced	0.56733271
66	MP0000627_abnormal_mammary_gland	0.55412651
67	MP0004859_abnormal_synaptic_plasticity	0.54651969
68	MP0000534_abnormal_ureter_morphology	0.52140460
69	MP0003137_abnormal_impulse_conducting	0.51142483
70	MP0000538_abnormal_urinary_bladder	0.50956420
71	MP0000383_abnormal_hair_follicle	0.50188030
72	MP0005330_cardiomyopathy	0.48428710
73	MP0010678_abnormal_skin_adnexa	0.48162829
74	MP0000003_abnormal_adipose_tissue	0.48023829
75	MP0000371_diluted_coat_color	0.47875147
76	MP0008775_abnormal_heart_ventricle	0.47742806
77	MP0005394_taste/olfaction_phenotype	0.47652413
78	MP0005499_abnormal_olfactory_system	0.47652413
79	MP0005551_abnormal_eye_electrophysiolog	0.47156191
80	MP0001324_abnormal_eye_pigmentation	0.46950036
81	MP0005319_abnormal_enzyme/_coenzyme	0.46424662
82	MP0002118_abnormal_lipid_homeostasis	0.45802788
83	MP0001764_abnormal_homeostasis	0.45660867
84	MP0003045_fibrosis	0.44882078
85	MP0003943_abnormal_hepatobiliary_system	0.44748756
86	MP0001845_abnormal_inflammatory_respons	0.43435461
87	MP0003936_abnormal_reproductive_system	0.43169180
88	MP0000613_abnormal_salivary_gland	0.42433399
89	MP0004142_abnormal_muscle_tone	0.41844905
90	MP0000470_abnormal_stomach_morphology	0.40678702
91	MP0003959_abnormal_lean_body	0.37269991
92	MP0003879_abnormal_hair_cell	0.37067544
93	MP0010094_abnormal_chromosome_stability	0.36787241
94	MP0000367_abnormal_coat/_hair	0.36764992
95	MP0008961_abnormal_basal_metabolism	0.36253582
96	MP0002078_abnormal_glucose_homeostasis	0.35725335
97	MP0009046_muscle_twitch	0.32656252
98	MP0004215_abnormal_myocardial_fiber	0.31778221
99	MP0002638_abnormal_pupillary_reflex	0.31108481
100	MP0001119_abnormal_female_reproductive	0.30867349

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.81995024
2	Scotoma (HP:0000575)	8.13683723
3	Cerebral palsy (HP:0100021)	6.47481733
4	Seborrheic dermatitis (HP:0001051)	5.96233813
5	Abnormality of macular pigmentation (HP:0008002)	5.91981622
6	Growth hormone excess (HP:0000845)	5.76940368
7	Abnormal rod and cone electroretinograms (HP:0008323)	5.50466563
8	Clubbing of toes (HP:0100760)	5.45772338
9	Attenuation of retinal blood vessels (HP:0007843)	5.29727425
10	Central scotoma (HP:0000603)	5.23168368
11	Abnormality of the fovea (HP:0000493)	4.80973414
12	Bony spicule pigmentary retinopathy (HP:0007737)	4.50773806
13	Esophageal neoplasm (HP:0100751)	3.82080356
14	Neoplasm of head and neck (HP:0012288)	3.82080356
15	Neonatal death (HP:0003811)	3.75513386
16	Exocrine pancreatic insufficiency (HP:0001738)	3.66087385
17	Abnormality of the gastric mucosa (HP:0004295)	3.57702508
18	Hypothermia (HP:0002045)	3.49758442
19	Irregular vertebral endplates (HP:0003301)	3.49625890
20	Joint swelling (HP:0001386)	3.30129876
21	Generalized aminoaciduria (HP:0002909)	3.19432934
22	Reduced antithrombin III activity (HP:0001976)	3.12284239
23	Right ventricular cardiomyopathy (HP:0011663)	3.06265941
24	Acne (HP:0001061)	2.96973075
25	Poor speech (HP:0002465)	2.95130887
26	Neoplasm of the lung (HP:0100526)	2.90686810
27	Male infertility (HP:0003251)	2.87885797
28	Ileus (HP:0002595)	2.87033105
29	Delayed gross motor development (HP:0002194)	2.84570525
30	Severe Myopia (HP:0011003)	2.82225445
31	Mitochondrial inheritance (HP:0001427)	2.79599437
32	Type I transferrin isoform profile (HP:0003642)	2.76394315
33	Hyperglycinemia (HP:0002154)	2.73709416
34	Abnormal hair whorl (HP:0010721)	2.71977434
35	Small epiphyses (HP:0010585)	2.71880866
36	Limb hypertonia (HP:0002509)	2.70577757
37	Congenital sensorineural hearing impairment (HP:0008527)	2.69409897
38	Rectal prolapse (HP:0002035)	2.67514965
39	Genu varum (HP:0002970)	2.61601664
40	Hyperpituitarism (HP:0010514)	2.58413277
41	Neoplasm of the respiratory system (HP:0100606)	2.56508733
42	Duplicated collecting system (HP:0000081)	2.54064532
43	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.48989124
44	Nephronophthisis (HP:0000090)	2.48840211
45	Abnormality of the vertebral endplates (HP:0005106)	2.48400714
46	Abnormality of the renal medulla (HP:0100957)	2.45932380
47	Widely spaced teeth (HP:0000687)	2.44960066
48	Abnormality of chloride homeostasis (HP:0011422)	2.42720292
49	Abnormality of DNA repair (HP:0003254)	2.41324440
50	Chromsome breakage (HP:0040012)	2.41037952
51	Arthropathy (HP:0003040)	2.34066692
52	Hyperglycinuria (HP:0003108)	2.31140432
53	Abnormality of the right ventricle (HP:0001707)	2.27788223
54	Freckling (HP:0001480)	2.27745371
55	Acute encephalopathy (HP:0006846)	2.25495985
56	Aortic regurgitation (HP:0001659)	2.20148084
57	Secondary amenorrhea (HP:0000869)	2.18862341
58	Facial hemangioma (HP:0000329)	2.17080759
59	Abnormal protein N-linked glycosylation (HP:0012347)	2.16909886
60	Abnormal protein glycosylation (HP:0012346)	2.16909886
61	Abnormal glycosylation (HP:0012345)	2.16909886
62	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.16909886
63	Abnormality of the renal collecting system (HP:0004742)	2.16576705
64	Rhizomelia (HP:0008905)	2.14211878
65	Azoospermia (HP:0000027)	2.13396838
66	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.08598397
67	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.07658464
68	Molar tooth sign on MRI (HP:0002419)	2.05535451
69	Abnormality of midbrain morphology (HP:0002418)	2.05535451
70	Hepatocellular necrosis (HP:0001404)	2.05480321
71	Muscular dystrophy (HP:0003560)	2.03355058
72	Melanoma (HP:0002861)	2.03021770
73	Aseptic necrosis (HP:0010885)	2.02307153
74	Waddling gait (HP:0002515)	2.02291320
75	Optic disc pallor (HP:0000543)	1.98043476
76	Abnormality of the intervertebral disk (HP:0005108)	1.96836903
77	Abnormality of the renal cortex (HP:0011035)	1.95058380
78	Anteriorly placed anus (HP:0001545)	1.94407338
79	Double outlet right ventricle (HP:0001719)	1.94331423
80	Congenital malformation of the right heart (HP:0011723)	1.94331423
81	Premature ovarian failure (HP:0008209)	1.93761155
82	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.93730780
83	Absent epiphyses (HP:0010577)	1.93730780
84	Cerebellar dysplasia (HP:0007033)	1.89726849
85	Abnormality of the tricuspid valve (HP:0001702)	1.88196734
86	Barrel-shaped chest (HP:0001552)	1.87756184
87	Short palm (HP:0004279)	1.87552049
88	Wide intermamillary distance (HP:0006610)	1.86046671
89	Ulnar deviation of the wrist (HP:0003049)	1.86036162
90	Mitral stenosis (HP:0001718)	1.83557748
91	Gowers sign (HP:0003391)	1.82014680
92	Pancreatic cysts (HP:0001737)	1.81104161
93	Meckel diverticulum (HP:0002245)	1.79404084
94	Abnormality of pyrimidine metabolism (HP:0004353)	1.78275823
95	Abnormality of the ileum (HP:0001549)	1.78177401
96	Hepatic necrosis (HP:0002605)	1.74434034
97	Osteomyelitis (HP:0002754)	1.72829566
98	Turricephaly (HP:0000262)	1.69201148
99	Vertebral arch anomaly (HP:0008438)	1.68093393
100	Broad alveolar ridges (HP:0000187)	1.67752738

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LMTK2	9.61155218
2	BCKDK	5.04099095
3	NME1	4.79175785
4	MAP3K12	3.58395760
5	ILK	2.94299674
6	PIK3CA	2.82444247
7	MYLK	2.06715853
8	TNIK	2.06037630
9	STK38	1.96109870
10	VRK2	1.93696490
11	FRK	1.93013973
12	PRKG2	1.85360154
13	NUAK1	1.70681406
14	BMPR1B	1.68654269
15	MAP4K2	1.51606040
16	MKNK2	1.44108399
17	PRKCQ	1.43233337
18	MAP3K7	1.38195033
19	DYRK3	1.25859619
20	PHKG2	1.20738546
21	PHKG1	1.20738546
22	ADRBK2	1.16915473
23	PRKD1	1.12165296
24	ERBB3	1.11865944
25	DMPK	1.06766001
26	STK16	1.06445679
27	PRKD2	1.04949772
28	RPS6KA4	0.98683453
29	WNK4	0.94140792
30	PNCK	0.86739624
31	PRKCE	0.84423790
32	CDK9	0.82282879
33	DAPK2	0.79693419
34	PAK3	0.78347926
35	DAPK1	0.75130432
36	CAMK2D	0.75076986
37	YES1	0.72898750
38	ROCK1	0.72236080
39	PIK3CG	0.69229902
40	PDK2	0.67156616
41	FER	0.65261038
42	HIPK2	0.64027636
43	SGK2	0.64013646
44	PAK1	0.63192332
45	BMX	0.62452990
46	GRK1	0.62279423
47	CSNK1D	0.60358644
48	AKT3	0.59519399
49	RPS6KB2	0.59325338
50	STK38L	0.57322057
51	CAMK1	0.57085145
52	PRKCG	0.55169853
53	MKNK1	0.52887472
54	WNK3	0.52873105
55	MUSK	0.52502361
56	PRKAA1	0.50554921
57	PRKG1	0.47829151
58	BRSK2	0.46008609
59	TLK1	0.44744911
60	PAK4	0.44562468
61	CAMKK2	0.41988476
62	SGK3	0.41551950
63	DAPK3	0.40933863
64	CDK8	0.39089788
65	PDGFRB	0.38775681
66	EPHB2	0.36884641
67	RPS6KA6	0.33391849
68	CAMK2B	0.32271460
69	MINK1	0.32098712
70	IKBKB	0.31832420
71	EIF2AK1	0.31279415
72	SGK494	0.30605170
73	SGK223	0.30605170
74	STK39	0.29987851
75	WEE1	0.29568362
76	NEK1	0.29350543
77	GSK3A	0.29221326
78	VRK1	0.28893398
79	PRKCA	0.27579757
80	INSRR	0.27571911
81	STK11	0.27232375
82	RPS6KC1	0.26983360
83	RPS6KL1	0.26983360
84	FGFR1	0.25279818
85	TGFBR1	0.24810225
86	EGFR	0.24711204
87	RPS6KA5	0.24608502
88	DYRK1A	0.24566700
89	CSK	0.24422077
90	ATM	0.24415956
91	NEK6	0.23570364
92	STK24	0.23335383
93	RPS6KA2	0.23196639
94	PRKACB	0.22813302
95	MAPK15	0.21776320
96	MAPK3	0.21167111
97	SRC	0.20864779
98	AKT2	0.20808294
99	ADRBK1	0.19485842
100	CAMK2A	0.19438931

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butanoate metabolism_Homo sapiens_hsa00650	7.70829145
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.77656563
3	Bile secretion_Homo sapiens_hsa04976	3.65136888
4	RNA polymerase_Homo sapiens_hsa03020	3.04339840
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.89513240
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.71390233
7	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	2.50899856
8	Pancreatic secretion_Homo sapiens_hsa04972	2.23728583
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.08914260
10	Circadian rhythm_Homo sapiens_hsa04710	2.07028862
11	Tight junction_Homo sapiens_hsa04530	1.93204736
12	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.83906074
13	Propanoate metabolism_Homo sapiens_hsa00640	1.78816880
14	Non-homologous end-joining_Homo sapiens_hsa03450	1.78748830
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.77357635
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.66283006
17	Basal transcription factors_Homo sapiens_hsa03022	1.66055956
18	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.54059145
19	Hepatitis C_Homo sapiens_hsa05160	1.50217570
20	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.46742470
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39964806
22	ABC transporters_Homo sapiens_hsa02010	1.31833694
23	One carbon pool by folate_Homo sapiens_hsa00670	1.28104073
24	Homologous recombination_Homo sapiens_hsa03440	1.24608582
25	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.18606747
26	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.18579765
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13780027
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.12728027
29	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.10471424
30	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.08811252
31	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.06125683
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.04574378
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.02755387
34	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.02389471
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.97873939
36	Sulfur metabolism_Homo sapiens_hsa00920	0.96377337
37	Retinol metabolism_Homo sapiens_hsa00830	0.92349094
38	Purine metabolism_Homo sapiens_hsa00230	0.89944887
39	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.88399714
40	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86279503
41	Galactose metabolism_Homo sapiens_hsa00052	0.85668400
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.85510012
43	Choline metabolism in cancer_Homo sapiens_hsa05231	0.85199114
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81798146
45	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.81636524
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.80621155
47	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.80043515
48	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.79865905
49	Base excision repair_Homo sapiens_hsa03410	0.78747956
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.78167833
51	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.76556205
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.75094567
53	RNA degradation_Homo sapiens_hsa03018	0.74643873
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.72886854
55	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.71366908
56	Peroxisome_Homo sapiens_hsa04146	0.65263480
57	Metabolic pathways_Homo sapiens_hsa01100	0.65087898
58	Huntingtons disease_Homo sapiens_hsa05016	0.65079176
59	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.64521423
60	Taste transduction_Homo sapiens_hsa04742	0.63752249
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63226149
62	Renin-angiotensin system_Homo sapiens_hsa04614	0.62261385
63	Caffeine metabolism_Homo sapiens_hsa00232	0.59288444
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.57304095
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.57091527
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56664011
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50661181
68	TNF signaling pathway_Homo sapiens_hsa04668	0.49050775
69	PPAR signaling pathway_Homo sapiens_hsa03320	0.47391837
70	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.46523943
71	Vibrio cholerae infection_Homo sapiens_hsa05110	0.45856591
72	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.45817910
73	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45484054
74	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42557106
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40613937
76	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.39400613
77	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.39193382
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39022307
79	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.38350714
80	Gastric acid secretion_Homo sapiens_hsa04971	0.37993706
81	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.35796493
82	Platelet activation_Homo sapiens_hsa04611	0.34770646
83	Oxidative phosphorylation_Homo sapiens_hsa00190	0.32455320
84	Mineral absorption_Homo sapiens_hsa04978	0.32452280
85	Pyruvate metabolism_Homo sapiens_hsa00620	0.31759100
86	Proteasome_Homo sapiens_hsa03050	0.30172547
87	Insulin secretion_Homo sapiens_hsa04911	0.28694842
88	Endocytosis_Homo sapiens_hsa04144	0.27943802
89	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.27138874
90	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.26917220
91	Glutathione metabolism_Homo sapiens_hsa00480	0.24114082
92	Wnt signaling pathway_Homo sapiens_hsa04310	0.23047843
93	Regulation of autophagy_Homo sapiens_hsa04140	0.23013230
94	Melanogenesis_Homo sapiens_hsa04916	0.22507335
95	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.22288170
96	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.21635732
97	AMPK signaling pathway_Homo sapiens_hsa04152	0.20599729
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.19384556
99	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.19229038
100	Complement and coagulation cascades_Homo sapiens_hsa04610	0.18471661

OGFOD1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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