OGFOD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.02336960
2L-phenylalanine catabolic process (GO:0006559)6.02336960
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.83399847
4L-phenylalanine metabolic process (GO:0006558)5.83399847
5aromatic amino acid family catabolic process (GO:0009074)4.70192784
6negative regulation of erythrocyte differentiation (GO:0045647)4.41076031
7coenzyme catabolic process (GO:0009109)4.31880197
8GDP-mannose metabolic process (GO:0019673)4.22109905
9deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.03090775
10lysine metabolic process (GO:0006553)3.95925573
11lysine catabolic process (GO:0006554)3.95925573
12cysteine metabolic process (GO:0006534)3.93345214
13response to peptidoglycan (GO:0032494)3.87317830
14glyoxylate metabolic process (GO:0046487)3.83628635
15sulfur amino acid catabolic process (GO:0000098)3.74911716
16ribosomal small subunit biogenesis (GO:0042274)3.72948578
17bile acid biosynthetic process (GO:0006699)3.71360457
18cellular ketone body metabolic process (GO:0046950)3.67878009
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.60668818
20cofactor catabolic process (GO:0051187)3.60422084
21mature B cell differentiation involved in immune response (GO:0002313)3.60350419
22kynurenine metabolic process (GO:0070189)3.57799252
23aspartate family amino acid catabolic process (GO:0009068)3.57713757
24pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.53057787
25indole-containing compound catabolic process (GO:0042436)3.51802021
26indolalkylamine catabolic process (GO:0046218)3.51802021
27tryptophan catabolic process (GO:0006569)3.51802021
28alpha-linolenic acid metabolic process (GO:0036109)3.50102599
29valine metabolic process (GO:0006573)3.48480358
30aromatic amino acid family metabolic process (GO:0009072)3.44181711
31positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.40716886
32tryptophan metabolic process (GO:0006568)3.39368237
33DNA deamination (GO:0045006)3.35901685
34base-excision repair, AP site formation (GO:0006285)3.34069390
35antigen processing and presentation of endogenous antigen (GO:0019883)3.33848231
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.33103482
37mannose metabolic process (GO:0006013)3.31969989
38proline biosynthetic process (GO:0006561)3.25772864
39bile acid metabolic process (GO:0008206)3.20282542
40alpha-amino acid catabolic process (GO:1901606)3.18406222
41purine deoxyribonucleotide catabolic process (GO:0009155)3.17945904
42drug transmembrane transport (GO:0006855)3.16525317
43triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.15247593
44ketone body metabolic process (GO:1902224)3.15033690
45regulation of cholesterol metabolic process (GO:0090181)3.14962801
46pinocytosis (GO:0006907)3.13872619
47pentose metabolic process (GO:0019321)3.13576836
482-oxoglutarate metabolic process (GO:0006103)3.13516093
49response to muramyl dipeptide (GO:0032495)3.12700412
50tyrosine metabolic process (GO:0006570)3.11507339
51regulation of triglyceride catabolic process (GO:0010896)3.11456336
52positive regulation of gamma-delta T cell activation (GO:0046645)3.10101692
53cellular amino acid catabolic process (GO:0009063)3.09524502
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.09295332
55fatty acid catabolic process (GO:0009062)3.08714781
56peroxisome fission (GO:0016559)3.07015100
57deoxyribonucleotide catabolic process (GO:0009264)3.02511458
58negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.02181380
59negative regulation of phagocytosis (GO:0050765)3.01685102
60UV protection (GO:0009650)3.00419938
61short-chain fatty acid metabolic process (GO:0046459)3.00258005
62pyrimidine nucleotide catabolic process (GO:0006244)2.99209715
63tricarboxylic acid metabolic process (GO:0072350)2.99019874
64fatty acid beta-oxidation (GO:0006635)2.97789305
65fatty acid oxidation (GO:0019395)2.96451468
66high-density lipoprotein particle remodeling (GO:0034375)2.96016579
67aldehyde catabolic process (GO:0046185)2.95557164
68monocarboxylic acid catabolic process (GO:0072329)2.95507740
69cellular modified amino acid catabolic process (GO:0042219)2.95469182
70branched-chain amino acid metabolic process (GO:0009081)2.95164882
71carboxylic acid catabolic process (GO:0046395)2.94772923
72organic acid catabolic process (GO:0016054)2.94772923
73glutamate metabolic process (GO:0006536)2.94156092
74protein maturation by protein folding (GO:0022417)2.94058318
75branched-chain amino acid catabolic process (GO:0009083)2.93894688
76L-alpha-amino acid transmembrane transport (GO:1902475)2.93098939
77viral transcription (GO:0019083)2.91164447
78pyrimidine-containing compound transmembrane transport (GO:0072531)2.89542637
79lipid oxidation (GO:0034440)2.88731991
80deoxyribose phosphate catabolic process (GO:0046386)2.88327690
81regulation of superoxide anion generation (GO:0032928)2.87699899
82intestinal cholesterol absorption (GO:0030299)2.87170299
83creatine metabolic process (GO:0006600)2.86988504
84protein import into peroxisome matrix (GO:0016558)2.86253544
85negative regulation of fibrinolysis (GO:0051918)2.85487450
86dicarboxylic acid catabolic process (GO:0043649)2.84250017
87oxaloacetate metabolic process (GO:0006107)2.83971808
88amino-acid betaine metabolic process (GO:0006577)2.81090419
89signal peptide processing (GO:0006465)2.79356339
90urea cycle (GO:0000050)2.79304788
91urea metabolic process (GO:0019627)2.79304788
92very long-chain fatty acid metabolic process (GO:0000038)2.78715753
93regulation of fibrinolysis (GO:0051917)2.78080586
94protein carboxylation (GO:0018214)2.75433917
95peptidyl-glutamic acid carboxylation (GO:0017187)2.75433917
96positive regulation of B cell differentiation (GO:0045579)2.74621967
97telomere maintenance via semi-conservative replication (GO:0032201)2.73344565
98antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.72582334
993-UTR-mediated mRNA stabilization (GO:0070935)2.72482167
100bile acid and bile salt transport (GO:0015721)2.72212066
101acetyl-CoA metabolic process (GO:0006084)2.70301822
102complement activation, alternative pathway (GO:0006957)2.69254355
103flavonoid metabolic process (GO:0009812)2.68979370
104succinate metabolic process (GO:0006105)2.68731693
105regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.68043567
106virion assembly (GO:0019068)2.66993986
107positive regulation by symbiont of host defense response (GO:0052509)2.66893691
108modulation by symbiont of host defense response (GO:0052031)2.66893691
109modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.66893691
110modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.66893691
111positive regulation by organism of defense response of other organism involved in symbiotic interact2.66893691
112modulation by symbiont of host immune response (GO:0052553)2.66893691
113regulation of mast cell degranulation (GO:0043304)2.66539755
114NADH metabolic process (GO:0006734)2.66382243
115drug transport (GO:0015893)2.66204668
116Peyers patch development (GO:0048541)2.66117246
117mucosal-associated lymphoid tissue development (GO:0048537)2.66117246
118negative regulation of cell size (GO:0045792)2.66000684
119fatty-acyl-CoA biosynthetic process (GO:0046949)2.65431599
120glucose catabolic process (GO:0006007)2.65312607
121response to mercury ion (GO:0046689)2.64596785
122acyl-CoA biosynthetic process (GO:0071616)2.63626045
123thioester biosynthetic process (GO:0035384)2.63626045
124indolalkylamine metabolic process (GO:0006586)2.63293207
125pentose-phosphate shunt (GO:0006098)2.62706150
126serine family amino acid biosynthetic process (GO:0009070)2.62559153
127serine family amino acid metabolic process (GO:0009069)2.62330617
128thioester metabolic process (GO:0035383)2.61720024
129acyl-CoA metabolic process (GO:0006637)2.61720024
130small molecule catabolic process (GO:0044282)2.61646612
131fatty-acyl-CoA metabolic process (GO:0035337)2.61221976
132peroxisome organization (GO:0007031)2.61014252
133detection of bacterium (GO:0016045)2.60306264
134regulation of acyl-CoA biosynthetic process (GO:0050812)2.60295925
135regulation of myeloid leukocyte mediated immunity (GO:0002886)2.60253318
136neutrophil activation involved in immune response (GO:0002283)2.59936808
137fatty acid elongation (GO:0030497)2.59734251
138NADPH regeneration (GO:0006740)2.59177001
139coenzyme A metabolic process (GO:0015936)2.58857802
140response to methylmercury (GO:0051597)2.58847558
141nitrogen cycle metabolic process (GO:0071941)2.58349746
142snRNA metabolic process (GO:0016073)2.58122904
143heme transport (GO:0015886)2.57292038
144Golgi transport vesicle coating (GO:0048200)2.57283123
145COPI coating of Golgi vesicle (GO:0048205)2.57283123
146regulation of cholesterol biosynthetic process (GO:0045540)2.57212479
147immunoglobulin mediated immune response (GO:0016064)2.57137339
148regulation of plasminogen activation (GO:0010755)2.56264303
149regulation of protein activation cascade (GO:2000257)2.55899202
150nucleotide salvage (GO:0043173)2.53357761
151translational termination (GO:0006415)2.52367387
152mature B cell differentiation (GO:0002335)2.51458645
153negative regulation of DNA-templated transcription, elongation (GO:0032785)2.50575384
154regulation of leukocyte degranulation (GO:0043300)2.50456941
155translational elongation (GO:0006414)2.49087828
156dosage compensation (GO:0007549)2.48806435
157negative regulation of fatty acid biosynthetic process (GO:0045717)2.48008770
158negative regulation of necroptotic process (GO:0060546)2.47219445
159positive thymic T cell selection (GO:0045059)2.46380482
160thymic T cell selection (GO:0045061)2.46124039
161pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.45210657
162nucleosome disassembly (GO:0006337)2.45090099
163protein-DNA complex disassembly (GO:0032986)2.45090099
164regulation of mammary gland epithelial cell proliferation (GO:0033599)2.43842156
165detection of other organism (GO:0098543)2.42170524
166negative regulation of B cell apoptotic process (GO:0002903)2.41956219
167negative regulation of cell killing (GO:0031342)2.41932116
168negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.41932116
169positive regulation of granulocyte differentiation (GO:0030854)2.41792226
170retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.40395299
171regulation of translational fidelity (GO:0006450)2.39634596
172cellular response to interleukin-4 (GO:0071353)2.38891167
173histone H3-K36 demethylation (GO:0070544)2.38471737
174spliceosomal tri-snRNP complex assembly (GO:0000244)2.38110044
175ribosomal small subunit assembly (GO:0000028)2.37233263
176intracellular estrogen receptor signaling pathway (GO:0030520)2.36976488
177Arp2/3 complex-mediated actin nucleation (GO:0034314)2.36385498
178DNA strand elongation involved in DNA replication (GO:0006271)2.35302433
179pyrimidine-containing compound salvage (GO:0008655)2.34974272
180pyrimidine nucleoside salvage (GO:0043097)2.34974272
181purine nucleotide salvage (GO:0032261)2.33996062
182regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.32387336
183maturation of SSU-rRNA (GO:0030490)2.32230127
184definitive hemopoiesis (GO:0060216)2.31837256
185snRNA processing (GO:0016180)2.30512790
186nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.30447513
187modulation by virus of host process (GO:0019054)2.30323623
188DNA strand elongation (GO:0022616)2.30309994
189regulation of type I interferon-mediated signaling pathway (GO:0060338)2.30079335
190viral life cycle (GO:0019058)2.29755757
191apoptotic process involved in morphogenesis (GO:0060561)2.28640283
192regulation of necrotic cell death (GO:0010939)2.28417598
193positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.28074550
194granulocyte differentiation (GO:0030851)2.26514033
195regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.26210952
196protein retention in ER lumen (GO:0006621)2.25415460

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.89726058
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.94536205
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.14756072
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.87259117
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.43433382
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.30855519
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.21635033
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.12946261
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.90085662
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73251381
11GATA1_22025678_ChIP-Seq_K562_Human2.47617497
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37308661
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35845185
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17835054
15* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.16835285
16E2F7_22180533_ChIP-Seq_HELA_Human2.13432066
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.00111224
18ZNF263_19887448_ChIP-Seq_K562_Human1.97029632
19ELK3_25401928_ChIP-Seq_HUVEC_Human1.95107835
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93702948
21* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93585038
22* VDR_24763502_ChIP-Seq_THP-1_Human1.84143191
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84064034
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.81187901
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.80716325
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.78922706
27MAF_26560356_Chip-Seq_TH1_Human1.76419044
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.75964009
29MAF_26560356_Chip-Seq_TH2_Human1.74264460
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.74120089
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.72957282
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72265633
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72051000
34UTX_26944678_Chip-Seq_JUKART_Human1.71443007
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67128028
36RACK7_27058665_Chip-Seq_MCF-7_Human1.65469369
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63344732
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62390468
39CIITA_25753668_ChIP-Seq_RAJI_Human1.60371001
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.58294589
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57939096
42KDM2B_26808549_Chip-Seq_DND41_Human1.56853033
43XRN2_22483619_ChIP-Seq_HELA_Human1.55025180
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49685496
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48445700
46TCF7_22412390_ChIP-Seq_EML_Mouse1.47017939
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45251472
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42146891
49NCOR1_26117541_ChIP-Seq_K562_Human1.40304031
50* SPI1_23547873_ChIP-Seq_NB4_Human1.39092996
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.38728334
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38651566
53* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38216954
54TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.37059041
55LXR_22292898_ChIP-Seq_THP-1_Human1.36912990
56GABP_19822575_ChIP-Seq_HepG2_Human1.36909083
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.36233687
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32108689
59SCL_19346495_ChIP-Seq_HPC-7_Human1.31724927
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.31495774
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.31195973
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31157048
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29634385
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29092362
65* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28125379
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27534133
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.26323967
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24971438
69SMC4_20622854_ChIP-Seq_HELA_Human1.24751960
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23996536
71CTCF_21964334_Chip-Seq_Bcells_Human1.23631067
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22443038
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22177973
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21979050
75PHF8_20622854_ChIP-Seq_HELA_Human1.21513945
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21326262
77KDM5A_27292631_Chip-Seq_BREAST_Human1.20330614
78DCP1A_22483619_ChIP-Seq_HELA_Human1.20042912
79* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19886581
80GATA1_19941826_ChIP-Seq_K562_Human1.19483789
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17812590
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17441529
83E2F1_20622854_ChIP-Seq_HELA_Human1.14469399
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14190883
85SPI1_23127762_ChIP-Seq_K562_Human1.14033953
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13800862
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13319282
88* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11780086
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11583612
90ERG_20517297_ChIP-Seq_VCAP_Human1.11181961
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.10743174
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10725506
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.10332094
94BCOR_27268052_Chip-Seq_Bcells_Human1.09819213
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09638386
96ETS1_20019798_ChIP-Seq_JURKAT_Human1.08925589
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07566243
98MYB_26560356_Chip-Seq_TH1_Human1.07265399
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06950858
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06866830
101BCL6_27268052_Chip-Seq_Bcells_Human1.06272690
102* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06186084
103CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05343286
104MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05071994
105* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04117826
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03043917
107DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01996069
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01488206
109SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00147657
110SA1_27219007_Chip-Seq_Bcells_Human0.99998184
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99720886
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99061560
113MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98304197
114CTCF_26484167_Chip-Seq_Bcells_Mouse0.98000915
115REST_18959480_ChIP-ChIP_MESCs_Mouse0.97296958
116THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97075416
117P68_20966046_ChIP-Seq_HELA_Human0.96273497
118RARB_24833708_ChIP-Seq_LIVER_Mouse0.95111079
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94321596
120VDR_21846776_ChIP-Seq_THP-1_Human0.93995544
121CTCF_27219007_Chip-Seq_Bcells_Human0.93022072
122* STAT1_20625510_ChIP-Seq_HELA_Human0.92592082
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91545122
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90464014
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89942475
126EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89450325
127PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89317589
128SA1_27219007_Chip-Seq_ERYTHROID_Human0.89311852
129TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89262070
130YY1_22570637_ChIP-Seq_MALME-3M_Human0.87009036
131OCT4_20526341_ChIP-Seq_ESCs_Human0.86536612
132PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85853846
133TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83489745
134MYC_19915707_ChIP-ChIP_AK7_Human0.82792246
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82674416
136SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82525331
137ELF1_20517297_ChIP-Seq_JURKAT_Human0.82446205
138* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.81898331
139GABP_17652178_ChIP-ChIP_JURKAT_Human0.81843062
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81642054
141* SOX2_21211035_ChIP-Seq_LN229_Human0.80264768
142EZH2_22144423_ChIP-Seq_EOC_Human0.80256253
143SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.79734426
144ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79506860
145P53_21459846_ChIP-Seq_SAOS-2_Human0.79431812
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77901264
147CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77390287
148* FOXP1_21924763_ChIP-Seq_HESCs_Human0.77139995
149MYC_22102868_ChIP-Seq_BL_Human0.76896580
150SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76489257
151RARB_27405468_Chip-Seq_BRAIN_Mouse0.76020858
152RARA_24833708_ChIP-Seq_LIVER_Mouse0.75464042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.76761338
2MP0005360_urolithiasis4.58004652
3MP0005365_abnormal_bile_salt4.41977638
4MP0008875_abnormal_xenobiotic_pharmacok3.86556290
5MP0005085_abnormal_gallbladder_physiolo3.81599703
6MP0003806_abnormal_nucleotide_metabolis3.37117940
7MP0009278_abnormal_bone_marrow3.03742463
8MP0003436_decreased_susceptibility_to2.76866431
9MP0002132_abnormal_respiratory_system2.72106522
10MP0005083_abnormal_biliary_tract2.70541319
11MP0010329_abnormal_lipoprotein_level2.69341874
12MP0001666_abnormal_nutrient_absorption2.49202723
13MP0003195_calcinosis2.46855612
14MP0008260_abnormal_autophagy2.43098492
15MP0005464_abnormal_platelet_physiology2.41602073
16MP0003763_abnormal_thymus_physiology2.39476461
17MP0002396_abnormal_hematopoietic_system2.36649431
18MP0004043_abnormal_pH_regulation2.35717745
19MP0005332_abnormal_amino_acid2.33229543
20MP0005397_hematopoietic_system_phenotyp2.24105988
21MP0001545_abnormal_hematopoietic_system2.24105988
22MP0009840_abnormal_foam_cell2.19415750
23MP0003868_abnormal_feces_composition2.19201517
24MP0005058_abnormal_lysosome_morphology2.16707268
25MP0003252_abnormal_bile_duct2.08460325
26MP0006036_abnormal_mitochondrial_physio2.08151487
27MP0001835_abnormal_antigen_presentation2.06384565
28MP0003656_abnormal_erythrocyte_physiolo2.01691821
29MP0005636_abnormal_mineral_homeostasis1.97250767
30MP0005025_abnormal_response_to1.96935353
31MP0004185_abnormal_adipocyte_glucose1.94930116
32MP0002118_abnormal_lipid_homeostasis1.94767705
33MP0009333_abnormal_splenocyte_physiolog1.93003424
34MP0003303_peritoneal_inflammation1.91761789
35MP0002837_dystrophic_cardiac_calcinosis1.88185099
36MP0002419_abnormal_innate_immunity1.86580874
37MP0003329_amyloid_beta_deposits1.79092560
38MP0004147_increased_porphyrin_level1.74934392
39MP0002876_abnormal_thyroid_physiology1.70977985
40MP0002420_abnormal_adaptive_immunity1.69645005
41MP0009643_abnormal_urine_homeostasis1.67801862
42MP0001819_abnormal_immune_cell1.67577895
43MP0002398_abnormal_bone_marrow1.66523785
44MP0000013_abnormal_adipose_tissue1.64622549
45MP0000465_gastrointestinal_hemorrhage1.63810469
46MP0000609_abnormal_liver_physiology1.63417783
47MP0005000_abnormal_immune_tolerance1.62669952
48MP0002909_abnormal_adrenal_gland1.58639376
49MP0001765_abnormal_ion_homeostasis1.58410302
50MP0005584_abnormal_enzyme/coenzyme_acti1.57329316
51MP0002723_abnormal_immune_serum1.56321634
52MP0000858_altered_metastatic_potential1.55951671
53MP0001800_abnormal_humoral_immune1.53872589
54MP0002722_abnormal_immune_system1.53610138
55MP0001849_ear_inflammation1.52129350
56MP0002452_abnormal_antigen_presenting1.50809650
57MP0005220_abnormal_exocrine_pancreas1.49841912
58MP0003191_abnormal_cellular_cholesterol1.48196250
59MP0005319_abnormal_enzyme/_coenzyme1.47790210
60MP0000716_abnormal_immune_system1.44631482
61MP0001986_abnormal_taste_sensitivity1.44511104
62MP0000685_abnormal_immune_system1.44130749
63MP0003111_abnormal_nucleus_morphology1.42615858
64MP0002429_abnormal_blood_cell1.42262673
65MP0000490_abnormal_crypts_of1.41792706
66MP0000703_abnormal_thymus_morphology1.41740602
67MP0003693_abnormal_embryo_hatching1.39596604
68MP0000747_muscle_weakness1.38159040
69MP0001764_abnormal_homeostasis1.36961900
70MP0002078_abnormal_glucose_homeostasis1.34643314
71MP0005451_abnormal_body_composition1.34409369
72MP0000689_abnormal_spleen_morphology1.34376789
73MP0004947_skin_inflammation1.31825563
74MP0000681_abnormal_thyroid_gland1.31741632
75MP0004859_abnormal_synaptic_plasticity1.29536150
76MP0000604_amyloidosis1.28312878
77MP0003724_increased_susceptibility_to1.27949543
78MP0001944_abnormal_pancreas_morphology1.27909228
79MP0002019_abnormal_tumor_incidence1.25134035
80MP0005387_immune_system_phenotype1.25126388
81MP0001790_abnormal_immune_system1.25126388
82MP0002693_abnormal_pancreas_physiology1.23937660
83MP0010155_abnormal_intestine_physiology1.23470029
84MP0004381_abnormal_hair_follicle1.22302661
85MP0004019_abnormal_vitamin_homeostasis1.21213123
86MP0002148_abnormal_hypersensitivity_rea1.20072606
87MP0002405_respiratory_system_inflammati1.19730462
88MP0004808_abnormal_hematopoietic_stem1.18632628
89MP0005535_abnormal_body_temperature1.17963552
90MP0005666_abnormal_adipose_tissue1.17935599
91MP0001756_abnormal_urination1.17597058
92MP0010094_abnormal_chromosome_stability1.16767448
93MP0002822_catalepsy1.14347977
94MP0009785_altered_susceptibility_to1.13000219
95MP0004270_analgesia1.12136340
96MP0003866_abnormal_defecation1.11252408
97MP0001853_heart_inflammation1.10640789
98MP0001873_stomach_inflammation1.09954844
99MP0004264_abnormal_extraembryonic_tissu1.09555421
100MP0002877_abnormal_melanocyte_morpholog1.08176608
101MP0001845_abnormal_inflammatory_respons1.07802135
102MP0005075_abnormal_melanosome_morpholog1.06299915
103MP0001533_abnormal_skeleton_physiology1.05666321
104MP0005501_abnormal_skin_physiology1.04773882
105MP0006035_abnormal_mitochondrial_morpho1.04597229
106MP0002138_abnormal_hepatobiliary_system1.03804612
107MP0000920_abnormal_myelination1.03315509
108MP0003183_abnormal_peptide_metabolism1.03117173
109MP0000313_abnormal_cell_death1.02164895
110MP0002064_seizures1.01416047
111MP0003880_abnormal_central_pattern0.99615383
112MP0004233_abnormal_muscle_weight0.97970273
113MP0009642_abnormal_blood_homeostasis0.96277555
114MP0001348_abnormal_lacrimal_gland0.95003508
115MP0005671_abnormal_response_to0.94670894
116MP0002272_abnormal_nervous_system0.94457378
117MP0006276_abnormal_autonomic_nervous0.93081334
118MP0008469_abnormal_protein_level0.92278691
119MP0003172_abnormal_lysosome_physiology0.91388432
120MP0004145_abnormal_muscle_electrophysio0.90243468
121MP0004130_abnormal_muscle_cell0.90233313
122MP0009697_abnormal_copulation0.89388425
123MP0003077_abnormal_cell_cycle0.89354130
124MP0003186_abnormal_redox_activity0.88531258
125MP0000598_abnormal_liver_morphology0.88023344
126MP0003635_abnormal_synaptic_transmissio0.88011290
127MP0000230_abnormal_systemic_arterial0.87831542
128MP0003705_abnormal_hypodermis_morpholog0.87605789
129MP0000015_abnormal_ear_pigmentation0.86711295
130MP0003953_abnormal_hormone_level0.85748586
131MP0003959_abnormal_lean_body0.85688644
132MP0005076_abnormal_cell_differentiation0.85503745
133MP0002249_abnormal_larynx_morphology0.85133171
134MP0005084_abnormal_gallbladder_morpholo0.84379847
135MP0002736_abnormal_nociception_after0.83445091
136MP0002735_abnormal_chemical_nociception0.83409646
137MP0005409_darkened_coat_color0.81651520
138MP0001529_abnormal_vocalization0.81613471
139MP0009745_abnormal_behavioral_response0.81092076
140MP0005448_abnormal_energy_balance0.80771887
141MP0009379_abnormal_foot_pigmentation0.80487723
142MP0009931_abnormal_skin_appearance0.79905381
143MP0010386_abnormal_urinary_bladder0.79397816
144MP0002229_neurodegeneration0.78690449
145MP0002733_abnormal_thermal_nociception0.78328281
146MP0000343_altered_response_to0.76791541
147MP0001970_abnormal_pain_threshold0.76330787
148MP0003315_abnormal_perineum_morphology0.76247931
149MP0005410_abnormal_fertilization0.76004300
150MP0001664_abnormal_digestion0.75039246
151MP0005379_endocrine/exocrine_gland_phen0.74939481
152MP0008961_abnormal_basal_metabolism0.73950043
153MP0004858_abnormal_nervous_system0.73927084
154MP0003633_abnormal_nervous_system0.72322151
155MP0000350_abnormal_cell_proliferation0.72235707
156MP0003786_premature_aging0.71978921
157MP0003300_gastrointestinal_ulcer0.71104612
158MP0000678_abnormal_parathyroid_gland0.70919283
159MP0001968_abnormal_touch/_nociception0.70612715
160MP0003879_abnormal_hair_cell0.70066235
161MP0000358_abnormal_cell_content/0.69239992
162MP0005621_abnormal_cell_physiology0.69105139
163MP0005375_adipose_tissue_phenotype0.67902467
164MP0005330_cardiomyopathy0.67332323
165MP0002970_abnormal_white_adipose0.67155387
166MP0002796_impaired_skin_barrier0.66867141
167MP0003453_abnormal_keratinocyte_physiol0.65935444
168MP0004142_abnormal_muscle_tone0.64607987
169MP0001661_extended_life_span0.64429876
170MP0001730_embryonic_growth_arrest0.64345366
171MP0008007_abnormal_cellular_replicative0.64223644
172MP0001905_abnormal_dopamine_level0.64105251
173MP0000003_abnormal_adipose_tissue0.63958270
174MP0005334_abnormal_fat_pad0.63920721
175MP0008569_lethality_at_weaning0.63094118
176MP0003638_abnormal_response/metabolism_0.62988343
177MP0002572_abnormal_emotion/affect_behav0.62599390
178MP0008873_increased_physiological_sensi0.62169443
179MP0002971_abnormal_brown_adipose0.62018882
180MP0002069_abnormal_eating/drinking_beha0.60209945
181MP0002136_abnormal_kidney_physiology0.60147084

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.69737354
2Ketosis (HP:0001946)4.03185613
3Intrahepatic cholestasis (HP:0001406)3.84465295
4Ketoacidosis (HP:0001993)3.75320341
5Hyperlipoproteinemia (HP:0010980)3.63454530
6Xanthomatosis (HP:0000991)3.63259975
7Obstructive lung disease (HP:0006536)3.63257922
8Chronic obstructive pulmonary disease (HP:0006510)3.63257922
9Hypertensive crisis (HP:0100735)3.56660110
10Petechiae (HP:0000967)3.53699829
11Hypoglycemic coma (HP:0001325)3.44942121
12Vacuolated lymphocytes (HP:0001922)3.42055261
13Prolonged partial thromboplastin time (HP:0003645)3.39273009
14Pheochromocytoma (HP:0002666)3.37050002
15Progressive muscle weakness (HP:0003323)3.35004487
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.30765138
17Abnormality of the heme biosynthetic pathway (HP:0010472)3.29571087
18Deep venous thrombosis (HP:0002625)3.29471807
19Seborrheic dermatitis (HP:0001051)3.29110021
20Ragged-red muscle fibers (HP:0003200)3.23675218
21Gout (HP:0001997)3.11151132
22Colitis (HP:0002583)3.11099168
23Late onset (HP:0003584)3.08228986
24Neuroendocrine neoplasm (HP:0100634)3.07497690
25Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.00382870
26Eczematoid dermatitis (HP:0000976)2.94072387
27Gastrointestinal inflammation (HP:0004386)2.92795491
28Abnormality of fatty-acid metabolism (HP:0004359)2.92038416
29Hypobetalipoproteinemia (HP:0003563)2.82368542
30Prolonged bleeding time (HP:0003010)2.81007282
31Cellulitis (HP:0100658)2.80053718
32Generalized aminoaciduria (HP:0002909)2.79367940
33Hepatosplenomegaly (HP:0001433)2.78579754
34Spontaneous abortion (HP:0005268)2.78028520
35Dicarboxylic aciduria (HP:0003215)2.77832177
36Abnormality of dicarboxylic acid metabolism (HP:0010995)2.77832177
37Hepatic necrosis (HP:0002605)2.77525640
38Centrally nucleated skeletal muscle fibers (HP:0003687)2.73898359
39Abnormality of macrophages (HP:0004311)2.69510844
40Hyperammonemia (HP:0001987)2.69056437
41Recurrent abscess formation (HP:0002722)2.64854899
42Panhypogammaglobulinemia (HP:0003139)2.64629458
43Brushfield spots (HP:0001088)2.63406098
44Recurrent fungal infections (HP:0002841)2.63158316
45Reticulocytosis (HP:0001923)2.62531887
46Inflammation of the large intestine (HP:0002037)2.59300952
47Fat malabsorption (HP:0002630)2.58146860
48Reduced antithrombin III activity (HP:0001976)2.57314529
49Abnormality of glycine metabolism (HP:0010895)2.55196065
50Abnormality of serine family amino acid metabolism (HP:0010894)2.55196065
51Epistaxis (HP:0000421)2.54971455
52Recurrent viral infections (HP:0004429)2.52323844
53Abnormal gallbladder physiology (HP:0012438)2.50921591
54Cholecystitis (HP:0001082)2.50921591
55Cerebral hemorrhage (HP:0001342)2.49131803
56Hyperglycinuria (HP:0003108)2.47885963
57Cerebral edema (HP:0002181)2.46718379
58Hyperthyroidism (HP:0000836)2.46631730
59Hyperbilirubinemia (HP:0002904)2.46559558
60Elevated erythrocyte sedimentation rate (HP:0003565)2.45752475
61Myopathic facies (HP:0002058)2.43926449
62Hyperglycinemia (HP:0002154)2.43847436
63Hepatocellular necrosis (HP:0001404)2.43593112
64Recurrent bacterial skin infections (HP:0005406)2.42222981
65Abnormality of reticulocytes (HP:0004312)2.40158103
66Microvesicular hepatic steatosis (HP:0001414)2.39462321
67Broad distal phalanx of finger (HP:0009836)2.38223586
68Hyperinsulinemic hypoglycemia (HP:0000825)2.38222536
69Type I transferrin isoform profile (HP:0003642)2.37765058
70Hypoglycemic seizures (HP:0002173)2.36816310
71Thoracic kyphosis (HP:0002942)2.35802935
72Posterior subcapsular cataract (HP:0007787)2.35133372
73Abnormality of the common coagulation pathway (HP:0010990)2.35084428
74Nasal polyposis (HP:0100582)2.35041943
75Meningitis (HP:0001287)2.34543092
76Metabolic acidosis (HP:0001942)2.33725277
77Purpura (HP:0000979)2.32805174
78Abnormality of purine metabolism (HP:0004352)2.31547489
79Granulocytopenia (HP:0001913)2.30800710
80Truncus arteriosus (HP:0001660)2.30463336
81Abnormality of the intrinsic pathway (HP:0010989)2.30139290
82Acute encephalopathy (HP:0006846)2.28764839
83Chronic mucocutaneous candidiasis (HP:0002728)2.27010365
84Recurrent cutaneous fungal infections (HP:0011370)2.27010365
85Atelectasis (HP:0100750)2.26248884
86Symptomatic seizures (HP:0011145)2.26027799
87Oligomenorrhea (HP:0000876)2.25139757
88Agammaglobulinemia (HP:0004432)2.23908265
89Tinnitus (HP:0000360)2.23629658
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23343780
91Exercise-induced myalgia (HP:0003738)2.23212016
92Abnormality of liposaccharide metabolism (HP:0010968)2.23054315
93Abnormality of glycosphingolipid metabolism (HP:0004343)2.23054315
94Abnormality of glycolipid metabolism (HP:0010969)2.23054315
95Lethargy (HP:0001254)2.22771545
96J-shaped sella turcica (HP:0002680)2.22583707
97Abnormal glycosylation (HP:0012345)2.21325266
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21325266
99Abnormal protein N-linked glycosylation (HP:0012347)2.21325266
100Abnormal protein glycosylation (HP:0012346)2.21325266
101Rhabdomyolysis (HP:0003201)2.19989293
102Myositis (HP:0100614)2.17370778
103Vertebral compression fractures (HP:0002953)2.15504796
104Complement deficiency (HP:0004431)2.14021223
105Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12141158
106Abnormality of the nasal mucosa (HP:0000433)2.11827646
107Hypolipoproteinemia (HP:0010981)2.11162246
108Mediastinal lymphadenopathy (HP:0100721)2.10990206
109Abnormality of pyrimidine metabolism (HP:0004353)2.10856093
110Steatorrhea (HP:0002570)2.10649839
111Abnormality of glutamine family amino acid metabolism (HP:0010902)2.10185768
112Abnormality of the columella (HP:0009929)2.09674782
113Polycythemia (HP:0001901)2.07811791
114Pustule (HP:0200039)2.07448901
115Alkalosis (HP:0001948)2.07300024
116Impaired platelet aggregation (HP:0003540)2.07224692
117Abnormal platelet function (HP:0011869)2.07224692
118Increased IgE level (HP:0003212)2.07161865
119Dysostosis multiplex (HP:0000943)2.06910293
120Easy fatigability (HP:0003388)2.06042510
121Abnormality of the pancreatic islet cells (HP:0006476)2.05977679
122Abnormality of endocrine pancreas physiology (HP:0012093)2.05977679
123Recurrent skin infections (HP:0001581)2.04452082
124Lactic acidosis (HP:0003128)2.04415073
125Abnormal gallbladder morphology (HP:0012437)2.03969934
126Aplasia/Hypoplasia of the thymus (HP:0010515)2.02839856
127Epiphyseal stippling (HP:0010655)2.02618846
128Spastic paraparesis (HP:0002313)2.02505720
129Microretrognathia (HP:0000308)2.01766379
130Abnormality of the thoracic spine (HP:0100711)2.00908430
131Mitochondrial inheritance (HP:0001427)2.00701351
132Abnormal mitochondria in muscle tissue (HP:0008316)1.99806013
133Muscle stiffness (HP:0003552)1.99616434
134Joint hemorrhage (HP:0005261)1.99519174
135Increased muscle lipid content (HP:0009058)1.99388931
136Irritability (HP:0000737)1.98777463
137Hemorrhage of the eye (HP:0011885)1.97515052
138Vomiting (HP:0002013)1.97384380
139Conjugated hyperbilirubinemia (HP:0002908)1.96006932
140Pallor (HP:0000980)1.95452418
141Abnormality of sulfur amino acid metabolism (HP:0004339)1.93279736
142Reticulocytopenia (HP:0001896)1.92924559
143Abnormality of methionine metabolism (HP:0010901)1.92339232
144Retinal dysplasia (HP:0007973)1.92168305
145Hypertriglyceridemia (HP:0002155)1.90958625
146Gastrointestinal dysmotility (HP:0002579)1.90536714
147Acute necrotizing encephalopathy (HP:0006965)1.89612107
148Hypoalphalipoproteinemia (HP:0003233)1.89598826
149Increased purine levels (HP:0004368)1.89357617
150Hyperuricemia (HP:0002149)1.89357617
151Methylmalonic aciduria (HP:0012120)1.89279244
152Bowel incontinence (HP:0002607)1.88716413
153Delayed CNS myelination (HP:0002188)1.88484287
154Abnormal large intestine physiology (HP:0012700)1.87759806
155Abnormality of serum amino acid levels (HP:0003112)1.87299190
156Cholelithiasis (HP:0001081)1.86333012
157Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.85390662
158Increased serum ferritin (HP:0003281)1.85020138
159Pancreatitis (HP:0001733)1.84030448
160Abnormal number of erythroid precursors (HP:0012131)1.83291628
161Increased cerebral lipofuscin (HP:0011813)1.83245798
162Abnormality of cells of the erythroid lineage (HP:0012130)1.83076451
163Abnormality of transition element cation homeostasis (HP:0011030)1.82480054
164Opisthotonus (HP:0002179)1.81154444
165Abnormality of nucleobase metabolism (HP:0010932)1.81080731
166Flattened epiphyses (HP:0003071)1.80818732
167Increased intramyocellular lipid droplets (HP:0012240)1.80642196
168Glycosuria (HP:0003076)1.80565711
169Abnormality of urine glucose concentration (HP:0011016)1.80565711
170Abnormality of iron homeostasis (HP:0011031)1.79873870
171Hypergonadotropic hypogonadism (HP:0000815)1.79742986
172Acute hepatic failure (HP:0006554)1.78928918
173Rough bone trabeculation (HP:0100670)1.78864036
174Broad face (HP:0000283)1.78354915
175Abnormal delayed hypersensitivity skin test (HP:0002963)1.78257954
176Viral hepatitis (HP:0006562)1.78233559
177Sensorimotor neuropathy (HP:0007141)1.77696814
178Abnormality of small intestinal villus morphology (HP:0011472)1.77100355
179Villous atrophy (HP:0011473)1.77100355
180Epidermoid cyst (HP:0200040)1.76514163
181Abnormality of the tricuspid valve (HP:0001702)1.76198462
182Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75831955
183Polygenic inheritance (HP:0010982)1.74021899
184Global brain atrophy (HP:0002283)1.73645935
185Thrombocytosis (HP:0001894)1.70867501
186Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70532432

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.32115215
2PASK3.59129158
3CDK192.89808517
4SMG12.88365789
5ERN12.66898948
6WNK42.59047760
7MST1R2.56279152
8MAP3K22.54316135
9NME22.12924758
10PRPF4B2.10854396
11STK392.10640094
12KSR22.08173483
13VRK22.07948464
14ICK2.07544861
15TAOK32.04766919
16INSRR2.01824906
17STK161.94361663
18OXSR11.89713643
19FGFR41.83750040
20MAPK151.83205765
21MAP2K21.79476728
22SIK11.71629648
23IRAK31.70021184
24DAPK21.64879748
25PIK3CG1.60795367
26PIM21.58887741
27TRIB31.53561201
28PRKD31.50973357
29MAP3K131.49887724
30FLT31.44025028
31CAMKK11.41553884
32MARK31.33507608
33MAP4K11.29111287
34TNK21.26911599
35BLK1.23772121
36TBK11.23491462
37CDK121.22716987
38NTRK11.21419130
39MAPKAPK51.20903974
40KDR1.20447109
41TESK21.20239021
42LRRK21.19255825
43TYK21.16932167
44MAP3K11.13447867
45MET1.13353447
46TAOK21.11148130
47SCYL21.09114777
48IRAK41.09036407
49EPHA41.08696365
50EPHA21.06460086
51SIK31.03254762
52UHMK11.00128192
53MAP3K30.98006259
54TAOK10.97591163
55HIPK20.94905227
56NME10.94303630
57EPHB10.94116627
58NTRK30.94081774
59CSNK1G30.92924277
60KIT0.90384659
61ARAF0.89956270
62EEF2K0.87588994
63RIPK40.86174288
64CDK70.85836467
65BRAF0.85011139
66TESK10.82874043
67CAMKK20.81339065
68MAP3K80.80784434
69MAP2K10.80523008
70MAP3K110.78407558
71IRAK20.78247401
72EPHA30.76668747
73JAK20.75930475
74CSNK1G20.75857143
75EIF2AK30.75210340
76RAF10.74408242
77TLK10.74263430
78BMX0.73413452
79CDK40.71763000
80MAP2K40.71296400
81SYK0.71226513
82DAPK10.70823004
83GRK60.69785293
84MARK20.68697629
85PDK40.68269313
86PDK30.68269313
87RPS6KB20.68045021
88WNK30.67638719
89PTK60.66833160
90BTK0.66545320
91HCK0.65591811
92RET0.64877387
93PRKCI0.64393096
94CAMK2D0.64374876
95MTOR0.63531920
96CAMK2G0.62686285
97MAPKAPK30.62028278
98NEK20.61513816
99CAMK2B0.61466933
100IRAK10.60427082
101RPS6KL10.59843800
102RPS6KC10.59843800
103FES0.59786292
104IKBKE0.59754581
105PAK40.59627294
106PKN20.59592908
107CSF1R0.59412251
108MAPK120.59305349
109MAP3K60.59250464
110IKBKB0.58502133
111MAP2K60.58244947
112SIK20.58225268
113ZAP700.58183574
114ABL20.57662066
115CDK50.57594229
116PDPK10.56720079
117CSK0.56331576
118CLK10.56012514
119DAPK30.55644284
120PDK10.55539550
121MAP3K140.53891724
122JAK30.53859051
123LYN0.53832332
124AURKA0.53135707
125RPS6KA40.52727924
126CDK90.52585247
127RPS6KA20.52323299
128PIK3CA0.51700746
129PRKCH0.51538266
130GRK50.50956482
131MINK10.50507666
132TIE10.50468443
133TNIK0.49804123
134PRKD20.49436685
135ILK0.48859604
136MAP2K30.48630003
137CSNK1A1L0.48007906
138PAK10.47800085
139STK100.47598318
140MAP3K70.47169338
141PRKCG0.46736216
142MAP3K100.46592626
143ATR0.44762831
144TEC0.44216986
145PRKCZ0.43722728
146PAK30.43261518
147CSNK1G10.43037653
148RPS6KA50.41464724
149MAPK110.40815589
150TTN0.40626553
151MAPKAPK20.40236066
152CDK80.39885533
153RPS6KA60.38960349

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.55871776
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.23068610
3Base excision repair_Homo sapiens_hsa034103.08829285
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.77499238
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.73949005
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61547333
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46236709
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41758443
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.37450099
10Acute myeloid leukemia_Homo sapiens_hsa052212.32751905
11Protein export_Homo sapiens_hsa030602.32338003
12Butanoate metabolism_Homo sapiens_hsa006502.26270447
13Sulfur metabolism_Homo sapiens_hsa009202.20799712
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.19608507
15Fatty acid elongation_Homo sapiens_hsa000622.19109815
16Fatty acid degradation_Homo sapiens_hsa000712.09620172
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07638107
18Tryptophan metabolism_Homo sapiens_hsa003802.07380207
19Peroxisome_Homo sapiens_hsa041462.01612744
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00263691
21Propanoate metabolism_Homo sapiens_hsa006401.96395397
22Arginine biosynthesis_Homo sapiens_hsa002201.93734694
23Folate biosynthesis_Homo sapiens_hsa007901.91531701
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89593536
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70657693
26Nitrogen metabolism_Homo sapiens_hsa009101.66811658
27Pyrimidine metabolism_Homo sapiens_hsa002401.65660856
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62074779
29Pyruvate metabolism_Homo sapiens_hsa006201.61738707
30B cell receptor signaling pathway_Homo sapiens_hsa046621.60106139
31Histidine metabolism_Homo sapiens_hsa003401.59197912
32Oxidative phosphorylation_Homo sapiens_hsa001901.57755975
33Primary immunodeficiency_Homo sapiens_hsa053401.57343596
34Steroid biosynthesis_Homo sapiens_hsa001001.55210646
35Fatty acid metabolism_Homo sapiens_hsa012121.53623727
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53492636
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51981043
38Mismatch repair_Homo sapiens_hsa034301.46912455
39Non-small cell lung cancer_Homo sapiens_hsa052231.46712698
40Sulfur relay system_Homo sapiens_hsa041221.45468438
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.43934943
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37170182
43Carbon metabolism_Homo sapiens_hsa012001.29945603
44Chronic myeloid leukemia_Homo sapiens_hsa052201.29796419
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28840498
46Selenocompound metabolism_Homo sapiens_hsa004501.28050023
47Apoptosis_Homo sapiens_hsa042101.25350495
48Pentose phosphate pathway_Homo sapiens_hsa000301.25223385
49beta-Alanine metabolism_Homo sapiens_hsa004101.24963353
50Leishmaniasis_Homo sapiens_hsa051401.24932485
51Biosynthesis of amino acids_Homo sapiens_hsa012301.23432842
52Parkinsons disease_Homo sapiens_hsa050121.23063557
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.19803135
54Complement and coagulation cascades_Homo sapiens_hsa046101.19533867
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19309979
56Bile secretion_Homo sapiens_hsa049761.17882240
57Chemical carcinogenesis_Homo sapiens_hsa052041.17881016
58Fat digestion and absorption_Homo sapiens_hsa049751.17830212
59PPAR signaling pathway_Homo sapiens_hsa033201.17083222
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16209626
61Osteoclast differentiation_Homo sapiens_hsa043801.15624675
62Herpes simplex infection_Homo sapiens_hsa051681.15240446
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12294171
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11742592
65Systemic lupus erythematosus_Homo sapiens_hsa053221.11004253
66Steroid hormone biosynthesis_Homo sapiens_hsa001401.09914918
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09791094
68Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07419489
69ABC transporters_Homo sapiens_hsa020101.03183476
70NF-kappa B signaling pathway_Homo sapiens_hsa040641.02025559
71Caffeine metabolism_Homo sapiens_hsa002321.01023500
72Bladder cancer_Homo sapiens_hsa052191.01003869
73Spliceosome_Homo sapiens_hsa030401.00874275
74Arginine and proline metabolism_Homo sapiens_hsa003300.99823268
75Alzheimers disease_Homo sapiens_hsa050100.97868024
76Pancreatic cancer_Homo sapiens_hsa052120.97838979
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97761495
78Homologous recombination_Homo sapiens_hsa034400.97741662
79Hepatitis C_Homo sapiens_hsa051600.96220294
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96181248
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94370034
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91952734
83Viral carcinogenesis_Homo sapiens_hsa052030.91723376
84Tuberculosis_Homo sapiens_hsa051520.91664280
85Glycerolipid metabolism_Homo sapiens_hsa005610.90689648
86Collecting duct acid secretion_Homo sapiens_hsa049660.90031799
87Nucleotide excision repair_Homo sapiens_hsa034200.89666371
88Hepatitis B_Homo sapiens_hsa051610.89242321
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.88874405
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87962880
91Other glycan degradation_Homo sapiens_hsa005110.87296294
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.86566587
93Influenza A_Homo sapiens_hsa051640.85550107
94VEGF signaling pathway_Homo sapiens_hsa043700.84924748
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84811632
96Synaptic vesicle cycle_Homo sapiens_hsa047210.83608900
97Starch and sucrose metabolism_Homo sapiens_hsa005000.83570181
98Shigellosis_Homo sapiens_hsa051310.82117393
99Epstein-Barr virus infection_Homo sapiens_hsa051690.81120870
100Vibrio cholerae infection_Homo sapiens_hsa051100.78952837
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77110275
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77026159
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75902429
104Metabolic pathways_Homo sapiens_hsa011000.75770020
105RNA polymerase_Homo sapiens_hsa030200.75580401
106N-Glycan biosynthesis_Homo sapiens_hsa005100.75457755
107Phenylalanine metabolism_Homo sapiens_hsa003600.74746198
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74564147
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72674330
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71965332
111Allograft rejection_Homo sapiens_hsa053300.69573523
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68906013
113Pancreatic secretion_Homo sapiens_hsa049720.68393973
114Glutathione metabolism_Homo sapiens_hsa004800.67918956
115Tyrosine metabolism_Homo sapiens_hsa003500.67882385
116Vitamin B6 metabolism_Homo sapiens_hsa007500.67800570
117Antigen processing and presentation_Homo sapiens_hsa046120.67782677
118mTOR signaling pathway_Homo sapiens_hsa041500.67584044
119Notch signaling pathway_Homo sapiens_hsa043300.65487391
120Retinol metabolism_Homo sapiens_hsa008300.65312211
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64707428
122HTLV-I infection_Homo sapiens_hsa051660.63933883
123Hematopoietic cell lineage_Homo sapiens_hsa046400.63882742
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62689472
125Measles_Homo sapiens_hsa051620.61673268
126Toxoplasmosis_Homo sapiens_hsa051450.61508879
127Autoimmune thyroid disease_Homo sapiens_hsa053200.61270023
128Viral myocarditis_Homo sapiens_hsa054160.61262069
129Legionellosis_Homo sapiens_hsa051340.59815095
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.58922204
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57690204
132Galactose metabolism_Homo sapiens_hsa000520.56603673
133Insulin secretion_Homo sapiens_hsa049110.55746517
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54301718
135Huntingtons disease_Homo sapiens_hsa050160.54295920
136Thyroid cancer_Homo sapiens_hsa052160.53894090
137Fanconi anemia pathway_Homo sapiens_hsa034600.53170754
138Lysosome_Homo sapiens_hsa041420.52464954
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51690609
140Endometrial cancer_Homo sapiens_hsa052130.51333473
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.51237988
142Graft-versus-host disease_Homo sapiens_hsa053320.51090809
143Fructose and mannose metabolism_Homo sapiens_hsa000510.50869996
144Platelet activation_Homo sapiens_hsa046110.49574253
145TNF signaling pathway_Homo sapiens_hsa046680.49375274
146Purine metabolism_Homo sapiens_hsa002300.48256033
147Phagosome_Homo sapiens_hsa041450.47966142
148T cell receptor signaling pathway_Homo sapiens_hsa046600.47581715
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47193943
150Vitamin digestion and absorption_Homo sapiens_hsa049770.46527442
151Intestinal immune network for IgA production_Homo sapiens_hsa046720.46076145
152Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45480560
153Insulin resistance_Homo sapiens_hsa049310.45473219
154Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44010195
155alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43542272
156Inositol phosphate metabolism_Homo sapiens_hsa005620.43101199
157Endocytosis_Homo sapiens_hsa041440.42184726
158Neurotrophin signaling pathway_Homo sapiens_hsa047220.42051236
159Linoleic acid metabolism_Homo sapiens_hsa005910.41852230
160Glycerophospholipid metabolism_Homo sapiens_hsa005640.41711935
161Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41203745
162Leukocyte transendothelial migration_Homo sapiens_hsa046700.41062863
163Sphingolipid metabolism_Homo sapiens_hsa006000.38771445
164Prion diseases_Homo sapiens_hsa050200.26814919
165Staphylococcus aureus infection_Homo sapiens_hsa051500.26216968
166Ribosome_Homo sapiens_hsa030100.24548519
167GABAergic synapse_Homo sapiens_hsa047270.23614411
168Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23450783
169Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23013821
170Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19255504
171SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15525033
172Glycosaminoglycan degradation_Homo sapiens_hsa005310.14913225
173Regulation of autophagy_Homo sapiens_hsa041400.12948455

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