OGFOD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.57245996
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.54795072
3mitochondrial calcium ion transport (GO:0006851)4.45141294
4ATP synthesis coupled proton transport (GO:0015986)4.44988556
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.44988556
6UV protection (GO:0009650)4.44710752
7DNA deamination (GO:0045006)4.37365867
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.34996825
9proteasome assembly (GO:0043248)4.32875491
10cotranslational protein targeting to membrane (GO:0006613)4.30249487
11protein targeting to ER (GO:0045047)4.25255475
12deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.20268957
13ribosomal small subunit assembly (GO:0000028)4.13479310
14protein localization to endoplasmic reticulum (GO:0070972)4.09732054
15viral transcription (GO:0019083)4.05262001
16establishment of protein localization to endoplasmic reticulum (GO:0072599)4.03796859
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.01631359
18signal peptide processing (GO:0006465)3.96088862
19translational termination (GO:0006415)3.95830179
20positive regulation of histone deacetylation (GO:0031065)3.91576221
21respiratory electron transport chain (GO:0022904)3.85503254
22negative regulation of cell size (GO:0045792)3.84009375
23amyloid precursor protein catabolic process (GO:0042987)3.83646844
24oxidative phosphorylation (GO:0006119)3.81598840
25electron transport chain (GO:0022900)3.80988118
26proline biosynthetic process (GO:0006561)3.79025264
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.74796490
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.74796490
29NADH dehydrogenase complex assembly (GO:0010257)3.74796490
30autophagic vacuole fusion (GO:0000046)3.74536852
31ribosomal small subunit biogenesis (GO:0042274)3.73358987
32protein complex biogenesis (GO:0070271)3.64777133
33translational elongation (GO:0006414)3.64461776
34NADH metabolic process (GO:0006734)3.62502847
35pteridine-containing compound biosynthetic process (GO:0042559)3.57687961
36GDP-mannose metabolic process (GO:0019673)3.54166866
37mitochondrial respiratory chain complex assembly (GO:0033108)3.53711074
38translation (GO:0006412)3.51814058
39guanosine-containing compound biosynthetic process (GO:1901070)3.49944461
40pentose metabolic process (GO:0019321)3.49819092
41L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.44670293
42respiratory chain complex IV assembly (GO:0008535)3.43247876
43regulation of apoptotic process involved in morphogenesis (GO:1902337)3.42187714
44COPI coating of Golgi vesicle (GO:0048205)3.42068124
45Golgi transport vesicle coating (GO:0048200)3.42068124
46nucleobase biosynthetic process (GO:0046112)3.40750600
47protein insertion into membrane (GO:0051205)3.36650151
48regulation of mitochondrial translation (GO:0070129)3.35539838
49GMP metabolic process (GO:0046037)3.28273842
50branched-chain amino acid catabolic process (GO:0009083)3.24909949
51purine nucleobase biosynthetic process (GO:0009113)3.22306025
522-deoxyribonucleotide biosynthetic process (GO:0009265)3.22275514
53deoxyribose phosphate biosynthetic process (GO:0046385)3.22275514
54DNA strand elongation involved in DNA replication (GO:0006271)3.21809149
55ribosomal large subunit biogenesis (GO:0042273)3.21759418
56viral life cycle (GO:0019058)3.21639080
57response to testosterone (GO:0033574)3.21382350
58protein maturation by protein folding (GO:0022417)3.20613638
59translational initiation (GO:0006413)3.18931010
60L-phenylalanine metabolic process (GO:0006558)3.14658141
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.14658141
62protein carboxylation (GO:0018214)3.14611019
63peptidyl-glutamic acid carboxylation (GO:0017187)3.14611019
64termination of RNA polymerase III transcription (GO:0006386)3.13219947
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.13219947
66folic acid metabolic process (GO:0046655)3.10672854
67telomere maintenance via semi-conservative replication (GO:0032201)3.10302600
68glutathione biosynthetic process (GO:0006750)3.09989858
69GTP biosynthetic process (GO:0006183)3.05919936
70L-serine metabolic process (GO:0006563)3.04452460
71maturation of SSU-rRNA (GO:0030490)3.03551002
72cellular protein complex disassembly (GO:0043624)3.03307053
73amino acid salvage (GO:0043102)3.02778968
74L-methionine salvage (GO:0071267)3.02778968
75L-methionine biosynthetic process (GO:0071265)3.02778968
76regulation of oxidative phosphorylation (GO:0002082)3.01947859
77UTP metabolic process (GO:0046051)3.01934830
78response to misfolded protein (GO:0051788)3.01265604
79pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.01180552
80DNA strand elongation (GO:0022616)2.98541387
81serine family amino acid biosynthetic process (GO:0009070)2.98318733
82CTP biosynthetic process (GO:0006241)2.97106934
83CTP metabolic process (GO:0046036)2.97106934
84cysteine metabolic process (GO:0006534)2.97057050
85peptidyl-arginine omega-N-methylation (GO:0035247)2.95611377
86pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.95219730
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.94076476
88UTP biosynthetic process (GO:0006228)2.93017576
89organelle membrane fusion (GO:0090174)2.92620656
90branched-chain amino acid metabolic process (GO:0009081)2.91865982
91dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.90511956
92formation of translation preinitiation complex (GO:0001731)2.90396019
93nucleobase-containing small molecule interconversion (GO:0015949)2.89825093
94protein retention in ER lumen (GO:0006621)2.88948474
95glucose catabolic process (GO:0006007)2.88673554
96pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.88232737
97iron-sulfur cluster assembly (GO:0016226)2.87305088
98metallo-sulfur cluster assembly (GO:0031163)2.87305088
99sulfur amino acid catabolic process (GO:0000098)2.86574004
100pteridine-containing compound metabolic process (GO:0042558)2.86047104
101regulation of metalloenzyme activity (GO:0048552)2.85504814
102AMP metabolic process (GO:0046033)2.85169488
103phosphatidylglycerol biosynthetic process (GO:0006655)2.84824390
104protein targeting to mitochondrion (GO:0006626)2.84049177
105negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.83574564
106protein deneddylation (GO:0000338)2.83565833
107erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.82581949
108L-phenylalanine catabolic process (GO:0006559)2.82581949
109pentose-phosphate shunt (GO:0006098)2.81952802
110heparin metabolic process (GO:0030202)2.81831789
111heparin biosynthetic process (GO:0030210)2.81831789
112protein targeting to membrane (GO:0006612)2.81714526
113mitotic nuclear envelope reassembly (GO:0007084)2.79583382
114nuclear envelope reassembly (GO:0031468)2.79583382
115positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.79412931
116nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.79224753
117proline metabolic process (GO:0006560)2.79094733
118amino sugar catabolic process (GO:0046348)2.78910948
119aldehyde catabolic process (GO:0046185)2.78665615
120tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78204707
121RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78204707
122pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.78080306
123pyrimidine nucleoside biosynthetic process (GO:0046134)2.78055233
124cullin deneddylation (GO:0010388)2.77489936
125pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.76599368
126NADPH regeneration (GO:0006740)2.76164013
127chaperone-mediated protein transport (GO:0072321)2.75486935
128nonribosomal peptide biosynthetic process (GO:0019184)2.75482264
129maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74831047
130tRNA modification (GO:0006400)2.74682997
131lipopolysaccharide biosynthetic process (GO:0009103)2.74599928
132lytic vacuole organization (GO:0080171)2.73531350
133lysosome organization (GO:0007040)2.73531350
134pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.72617313
135positive regulation of triglyceride biosynthetic process (GO:0010867)2.72276113
136cellular component biogenesis (GO:0044085)2.72200204
137cytochrome complex assembly (GO:0017004)2.71425048
138zinc ion transmembrane transport (GO:0071577)2.70376003
139negative regulation of DNA-templated transcription, elongation (GO:0032785)2.70363754
140mannose metabolic process (GO:0006013)2.69055566
141regulation of mammary gland epithelial cell proliferation (GO:0033599)2.68010500
142histone arginine methylation (GO:0034969)2.67472687
143regulation of histone deacetylation (GO:0031063)2.65263912
144N-acetylneuraminate metabolic process (GO:0006054)2.64352216
145viral mRNA export from host cell nucleus (GO:0046784)2.62507257
146positive regulation of lymphocyte apoptotic process (GO:0070230)2.62130832
147galactose catabolic process (GO:0019388)2.56759907
148mannosylation (GO:0097502)2.56107617
149cellular response to virus (GO:0098586)2.55396401
150protein import into peroxisome matrix (GO:0016558)2.55296151
151mitochondrial calcium ion homeostasis (GO:0051560)2.55244563
152transcription from mitochondrial promoter (GO:0006390)2.55040630
153misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.53848200
154neurotransmitter catabolic process (GO:0042135)2.53074935
155pattern specification involved in kidney development (GO:0061004)2.53009257
156regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.50238466
157spliceosomal tri-snRNP complex assembly (GO:0000244)2.48738366
158basic amino acid transport (GO:0015802)2.46043646
159amyloid precursor protein metabolic process (GO:0042982)2.45722044
160negative regulation of viral release from host cell (GO:1902187)2.45154341
161rRNA transcription (GO:0009303)2.42844981
162pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.42098440
1634-hydroxyproline metabolic process (GO:0019471)2.40925192
164positive regulation of histone acetylation (GO:0035066)2.39704249
165cellular response to ATP (GO:0071318)2.39050947
166negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.37976099
167negative regulation of macroautophagy (GO:0016242)2.37637662
168lymphocyte apoptotic process (GO:0070227)2.37457380
169regulation of hydrogen peroxide metabolic process (GO:0010310)2.35747264
170regulation of cholesterol storage (GO:0010885)2.34962655
171oligosaccharide catabolic process (GO:0009313)2.34914893
172low-density lipoprotein particle clearance (GO:0034383)2.34627695
173biotin metabolic process (GO:0006768)2.34139493
174ubiquinone biosynthetic process (GO:0006744)2.33333162
175L-alpha-amino acid transmembrane transport (GO:1902475)2.31754296
176post-embryonic morphogenesis (GO:0009886)2.31613297
177peptidyl-histidine modification (GO:0018202)2.31074523
178endosome to pigment granule transport (GO:0043485)2.30559826
179endosome to melanosome transport (GO:0035646)2.30559826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.21103443
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.13189500
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.98038098
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.88096738
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.82619879
6E2F7_22180533_ChIP-Seq_HELA_Human3.80765241
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.68775924
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.47796068
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.25760951
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.23103792
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.11545708
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98900118
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96669549
14LXR_22292898_ChIP-Seq_THP-1_Human2.89594513
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82383473
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.69290824
17DCP1A_22483619_ChIP-Seq_HELA_Human2.46840361
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44133148
19E2F1_18555785_ChIP-Seq_MESCs_Mouse2.42696147
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41881724
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39980338
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.37226783
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.37122853
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33540962
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.32606095
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30538009
27VDR_23849224_ChIP-Seq_CD4+_Human2.28843606
28XRN2_22483619_ChIP-Seq_HELA_Human2.21625882
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17109195
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13767988
31TET1_21451524_ChIP-Seq_MESCs_Mouse2.13335379
32P68_20966046_ChIP-Seq_HELA_Human2.12270535
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08580898
34ELK3_25401928_ChIP-Seq_HUVEC_Human2.07288704
35GABP_19822575_ChIP-Seq_HepG2_Human2.06954061
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.05370288
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.02508328
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.01042383
39ELF1_20517297_ChIP-Seq_JURKAT_Human2.00502084
40RACK7_27058665_Chip-Seq_MCF-7_Human1.99546014
41CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.91031036
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89917797
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86472299
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.84316985
45FOXP3_21729870_ChIP-Seq_TREG_Human1.82234993
46ZNF263_19887448_ChIP-Seq_K562_Human1.77624718
47BCL6_27268052_Chip-Seq_Bcells_Human1.77215491
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.74911420
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74390770
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71613677
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70729058
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68554437
53MYC_22102868_ChIP-Seq_BL_Human1.67424952
54BCOR_27268052_Chip-Seq_Bcells_Human1.67106880
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.65952688
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.62539270
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62209328
58TTF2_22483619_ChIP-Seq_HELA_Human1.61477758
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61153884
60TP53_22127205_ChIP-Seq_IMR90_Human1.60669305
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60327210
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.59038567
63SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.58845292
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58456181
65SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.57358464
66E2F1_20622854_ChIP-Seq_HELA_Human1.55818192
67CTCF_26484167_Chip-Seq_Bcells_Mouse1.54680128
68PHF8_20622854_ChIP-Seq_HELA_Human1.54263757
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49418138
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49234157
71SMC4_20622854_ChIP-Seq_HELA_Human1.48555968
72AR_21909140_ChIP-Seq_LNCAP_Human1.47238012
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46944250
74RARB_24833708_ChIP-Seq_LIVER_Mouse1.46244499
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.43566923
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42861501
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.42255505
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41959651
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37789506
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37391908
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36932987
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36512053
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36258819
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36202902
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.36106855
86SA1_27219007_Chip-Seq_Bcells_Human1.35895152
87CTCF_27219007_Chip-Seq_Bcells_Human1.34982792
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.34470249
89ELK1_22589737_ChIP-Seq_MCF10A_Human1.31194124
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30630611
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27756475
92RXR_22158963_ChIP-Seq_LIVER_Mouse1.27752815
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27423238
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27035646
95PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26462575
96EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26198386
97CIITA_25753668_ChIP-Seq_RAJI_Human1.25025162
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24569250
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.24486877
100RARA_24833708_ChIP-Seq_LIVER_Mouse1.24420104
101NCOR1_26117541_ChIP-Seq_K562_Human1.24311967
102ELK1_19687146_ChIP-ChIP_HELA_Human1.23965616
103CTCF_20526341_ChIP-Seq_ESCs_Human1.23821010
104KDM2B_26808549_Chip-Seq_DND41_Human1.23791192
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23149440
106E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22134210
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20726874
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20414436
109TP63_22573176_ChIP-Seq_HFKS_Human1.18998311
110MAF_26560356_Chip-Seq_TH2_Human1.18140240
111CREB1_26743006_Chip-Seq_LNCaP_Human1.17960646
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17896586
113CTCF_21964334_Chip-Seq_Bcells_Human1.17031532
114TBX5_21415370_ChIP-Seq_HL-1_Mouse1.16934629
115ESR2_21235772_ChIP-Seq_MCF-7_Human1.15861131
116EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15398386
117RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15045659
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14424635
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14284199
120ATF3_27146783_Chip-Seq_COLON_Human1.13929402
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12887819
122CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12482604
123MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11512118
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10234878
125RAC3_21632823_ChIP-Seq_H3396_Human1.10176389
126TFEB_21752829_ChIP-Seq_HELA_Human1.08888703
127MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08747796
128RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07802829
129MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07397173
130CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05257038
131KDM5A_27292631_Chip-Seq_BREAST_Human1.04868730
132PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04742935
133KDM2B_26808549_Chip-Seq_K562_Human1.04476671
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03797293
135P300_27268052_Chip-Seq_Bcells_Human1.02850830
136VDR_24763502_ChIP-Seq_THP-1_Human1.02768181
137ERA_21632823_ChIP-Seq_H3396_Human1.02704545
138NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01202325
139KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00529213
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99874815
141SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99003485
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98126671
143GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97760408
144YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97619844
145GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92667046
146E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91929024
147POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91856909
148CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91523860
149PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89274023
150YY1_22570637_ChIP-Seq_MALME-3M_Human0.89039971
151MYC_18940864_ChIP-ChIP_HL60_Human0.88317743
152ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87849630
153SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85185716
154EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83832978
155POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.81932075
156TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81797006
157SPI1_23547873_ChIP-Seq_NB4_Human0.81115997
158SOX17_20123909_ChIP-Seq_XEN_Mouse0.79880260
159SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79712592
160FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79474739
161TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79309183
162VDR_21846776_ChIP-Seq_THP-1_Human0.79215730
163KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79203615
164FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.79005719
165FOXP1_21924763_ChIP-Seq_HESCs_Human0.78791808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.26267002
2MP0003806_abnormal_nucleotide_metabolis4.14870427
3MP0003186_abnormal_redox_activity3.64584128
4MP0006036_abnormal_mitochondrial_physio3.19802795
5MP0002139_abnormal_hepatobiliary_system2.93463934
6MP0003693_abnormal_embryo_hatching2.88533796
7MP0003172_abnormal_lysosome_physiology2.64525555
8MP0009840_abnormal_foam_cell2.53655547
9MP0003011_delayed_dark_adaptation2.53039871
10MP0005332_abnormal_amino_acid2.45142739
11MP0004858_abnormal_nervous_system2.28128314
12MP0002837_dystrophic_cardiac_calcinosis2.27042464
13MP0005408_hypopigmentation2.26193454
14MP0003195_calcinosis2.19447100
15MP0009278_abnormal_bone_marrow2.18223363
16MP0005379_endocrine/exocrine_gland_phen2.17551213
17MP0005360_urolithiasis2.15111107
18MP0004043_abnormal_pH_regulation2.07753221
19MP0005220_abnormal_exocrine_pancreas2.02018820
20MP0009643_abnormal_urine_homeostasis2.00540931
21MP0005085_abnormal_gallbladder_physiolo1.97646177
22MP0005257_abnormal_intraocular_pressure1.94042879
23MP0005636_abnormal_mineral_homeostasis1.93008050
24MP0001764_abnormal_homeostasis1.91443839
25MP0003656_abnormal_erythrocyte_physiolo1.89066775
26MP0005058_abnormal_lysosome_morphology1.87178069
27MP0001756_abnormal_urination1.86196860
28MP0009697_abnormal_copulation1.84569955
29MP0002877_abnormal_melanocyte_morpholog1.82751990
30MP0000681_abnormal_thyroid_gland1.81889488
31MP0005365_abnormal_bile_salt1.79912347
32MP0006035_abnormal_mitochondrial_morpho1.79788127
33MP0002653_abnormal_ependyma_morphology1.75765980
34MP0004957_abnormal_blastocyst_morpholog1.75529154
35MP0003646_muscle_fatigue1.74939259
36MP0002163_abnormal_gland_morphology1.71851357
37MP0002396_abnormal_hematopoietic_system1.66607170
38MP0008438_abnormal_cutaneous_collagen1.64699544
39MP0003718_maternal_effect1.64185339
40MP0005464_abnormal_platelet_physiology1.62288963
41MP0003705_abnormal_hypodermis_morpholog1.61108525
42MP0005319_abnormal_enzyme/_coenzyme1.59602017
43MP0002138_abnormal_hepatobiliary_system1.59241681
44MP0009379_abnormal_foot_pigmentation1.59107800
45MP0008004_abnormal_stomach_pH1.56381612
46MP0001666_abnormal_nutrient_absorption1.54339992
47MP0008875_abnormal_xenobiotic_pharmacok1.52539922
48MP0009384_cardiac_valve_regurgitation1.50661977
49MP0002876_abnormal_thyroid_physiology1.50210516
50MP0005670_abnormal_white_adipose1.44055284
51MP0004019_abnormal_vitamin_homeostasis1.42748316
52MP0000538_abnormal_urinary_bladder1.41357084
53MP0003283_abnormal_digestive_organ1.39347244
54MP0004233_abnormal_muscle_weight1.38403445
55MP0003136_yellow_coat_color1.34454848
56MP0000372_irregular_coat_pigmentation1.34397741
57MP0002089_abnormal_postnatal_growth/wei1.29110166
58MP0001873_stomach_inflammation1.28449541
59MP0000749_muscle_degeneration1.25118643
60MP0003183_abnormal_peptide_metabolism1.25029274
61MP0005076_abnormal_cell_differentiation1.24425933
62MP0002638_abnormal_pupillary_reflex1.23798067
63MP0002933_joint_inflammation1.23095497
64MP0005584_abnormal_enzyme/coenzyme_acti1.21970752
65MP0001853_heart_inflammation1.21424325
66MP0000358_abnormal_cell_content/1.19350035
67MP0008007_abnormal_cellular_replicative1.19315446
68MP0000013_abnormal_adipose_tissue1.19292264
69MP0009333_abnormal_splenocyte_physiolog1.19027134
70MP0001270_distended_abdomen1.16049010
71MP0005330_cardiomyopathy1.12695413
72MP0003436_decreased_susceptibility_to1.10247137
73MP0004272_abnormal_basement_membrane1.06589641
74MP0001849_ear_inflammation1.05024730
75MP0001661_extended_life_span1.04608946
76MP0000015_abnormal_ear_pigmentation1.04122884
77MP0010329_abnormal_lipoprotein_level1.03837188
78MP0003878_abnormal_ear_physiology1.02605929
79MP0005377_hearing/vestibular/ear_phenot1.02605929
80MP0005666_abnormal_adipose_tissue1.01959089
81MP0002938_white_spotting1.01868164
82MP0001944_abnormal_pancreas_morphology1.00942927
83MP0003077_abnormal_cell_cycle1.00364010
84MP0002254_reproductive_system_inflammat0.99069369
85MP0001765_abnormal_ion_homeostasis0.98287140
86MP0003786_premature_aging0.98270691
87MP0002249_abnormal_larynx_morphology0.96764512
88MP0002909_abnormal_adrenal_gland0.96328469
89MP0005266_abnormal_metabolism0.95755032
90MP0001905_abnormal_dopamine_level0.92348777
91MP0003191_abnormal_cellular_cholesterol0.92328034
92MP0000678_abnormal_parathyroid_gland0.92121681
93MP0005084_abnormal_gallbladder_morpholo0.91891888
94MP0000371_diluted_coat_color0.91849213
95MP0005646_abnormal_pituitary_gland0.91538360
96MP0002136_abnormal_kidney_physiology0.90905244
97MP0008932_abnormal_embryonic_tissue0.90421900
98MP0000858_altered_metastatic_potential0.90228862
99MP0000609_abnormal_liver_physiology0.89745495
100MP0001664_abnormal_digestion0.89443161
101MP0006072_abnormal_retinal_apoptosis0.89342555
102MP0000751_myopathy0.88138716
103MP0001986_abnormal_taste_sensitivity0.87201732
104MP0006292_abnormal_olfactory_placode0.86960525
105MP0000230_abnormal_systemic_arterial0.86267576
106MP0003942_abnormal_urinary_system0.85778150
107MP0004036_abnormal_muscle_relaxation0.85726840
108MP0005083_abnormal_biliary_tract0.84655531
109MP0003566_abnormal_cell_adhesion0.84528077
110MP0002118_abnormal_lipid_homeostasis0.84518801
111MP0002148_abnormal_hypersensitivity_rea0.83999102
112MP0005508_abnormal_skeleton_morphology0.83885709
113MP0003123_paternal_imprinting0.83642887
114MP0000462_abnormal_digestive_system0.83617589
115MP0001186_pigmentation_phenotype0.83358539
116MP0008469_abnormal_protein_level0.82443350
117MP0004147_increased_porphyrin_level0.81990356
118MP0000750_abnormal_muscle_regeneration0.81879595
119MP0001485_abnormal_pinna_reflex0.81575779
120MP0005395_other_phenotype0.80710067
121MP0010386_abnormal_urinary_bladder0.80167187
122MP0003638_abnormal_response/metabolism_0.80112429
123MP0004133_heterotaxia0.79748653
124MP0002075_abnormal_coat/hair_pigmentati0.79138668
125MP0005390_skeleton_phenotype0.77107608
126MP0005376_homeostasis/metabolism_phenot0.77078938
127MP0001663_abnormal_digestive_system0.76940647
128MP0002135_abnormal_kidney_morphology0.76589628
129MP0001958_emphysema0.76417762
130MP0000747_muscle_weakness0.76293288
131MP0010030_abnormal_orbit_morphology0.73385226
132MP0002098_abnormal_vibrissa_morphology0.73091251
133MP0008058_abnormal_DNA_repair0.73066453
134MP0000343_altered_response_to0.73040414
135MP0003252_abnormal_bile_duct0.72968796
136MP0002132_abnormal_respiratory_system0.72525313
137MP0000598_abnormal_liver_morphology0.72486851
138MP0004215_abnormal_myocardial_fiber0.72409597
139MP0005503_abnormal_tendon_morphology0.71427498
140MP0001533_abnormal_skeleton_physiology0.70806482
141MP0002078_abnormal_glucose_homeostasis0.70047172
142MP0002822_catalepsy0.69874138
143MP0004084_abnormal_cardiac_muscle0.69858236
144MP0000003_abnormal_adipose_tissue0.69406694
145MP0005381_digestive/alimentary_phenotyp0.69280380
146MP0003329_amyloid_beta_deposits0.69072938
147MP0003866_abnormal_defecation0.68959784
148MP0002693_abnormal_pancreas_physiology0.68453685
149MP0009642_abnormal_blood_homeostasis0.67276016
150MP0002060_abnormal_skin_morphology0.66472016
151MP0002970_abnormal_white_adipose0.65987871
152MP0003279_aneurysm0.64734603
153MP0002269_muscular_atrophy0.64661470
154MP0000566_synostosis0.64412556
155MP0008260_abnormal_autophagy0.63484541

Predicted human phenotypes

RankGene SetZ-score
1Stridor (HP:0010307)4.36250536
2Acute necrotizing encephalopathy (HP:0006965)4.01004173
3Hepatic necrosis (HP:0002605)3.95537583
4Abnormal mitochondria in muscle tissue (HP:0008316)3.93301832
5Acute encephalopathy (HP:0006846)3.91929444
6Mitochondrial inheritance (HP:0001427)3.83822160
7Hepatocellular necrosis (HP:0001404)3.83087130
8Microretrognathia (HP:0000308)3.60641754
9Increased CSF lactate (HP:0002490)3.59853741
10Irregular epiphyses (HP:0010582)3.45323055
11Increased neuronal autofluorescent lipopigment (HP:0002074)3.44794467
12Vacuolated lymphocytes (HP:0001922)3.40236935
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.38032443
14Dysostosis multiplex (HP:0000943)3.36664812
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.30594351
16Hypokalemic alkalosis (HP:0001949)3.29104653
17Increased hepatocellular lipid droplets (HP:0006565)3.28888941
18J-shaped sella turcica (HP:0002680)3.23941636
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.22685289
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.22685289
21Testicular atrophy (HP:0000029)3.20430501
22Increased cerebral lipofuscin (HP:0011813)3.20400958
23Hyperglycinemia (HP:0002154)3.15416908
24Progressive macrocephaly (HP:0004481)3.12994105
25Type I transferrin isoform profile (HP:0003642)3.12292757
26Abnormality of cells of the erythroid lineage (HP:0012130)3.09889770
27Lactic acidosis (HP:0003128)3.08799732
28Lipid accumulation in hepatocytes (HP:0006561)3.08433295
29Increased intramyocellular lipid droplets (HP:0012240)3.05243159
30Hyperthyroidism (HP:0000836)3.03536808
31Hyperacusis (HP:0010780)2.99050248
32Increased serum lactate (HP:0002151)2.97602654
33Abnormal number of erythroid precursors (HP:0012131)2.97128210
34Abnormality of glycolipid metabolism (HP:0010969)2.95729379
35Abnormality of liposaccharide metabolism (HP:0010968)2.95729379
36Abnormality of glycosphingolipid metabolism (HP:0004343)2.95729379
37Cerebral edema (HP:0002181)2.94127490
38Abnormality of urine glucose concentration (HP:0011016)2.94090732
39Glycosuria (HP:0003076)2.94090732
40Renal Fanconi syndrome (HP:0001994)2.91865190
41Achilles tendon contracture (HP:0001771)2.89680789
42Increased muscle lipid content (HP:0009058)2.88238751
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.88188489
44Hyperactive renin-angiotensin system (HP:0000841)2.87264250
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.87180618
46Abnormality of polysaccharide metabolism (HP:0011012)2.87180618
47Abnormality of glycosaminoglycan metabolism (HP:0004371)2.87180618
48Dicarboxylic aciduria (HP:0003215)2.84611995
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.84611995
50Abnormality of glycine metabolism (HP:0010895)2.83563893
51Abnormality of serine family amino acid metabolism (HP:0010894)2.83563893
52Methylmalonic aciduria (HP:0012120)2.83091247
53Hyperglycinuria (HP:0003108)2.82917661
54Abnormality of the Achilles tendon (HP:0005109)2.80629465
55Urinary glycosaminoglycan excretion (HP:0003541)2.79816395
56Mucopolysacchariduria (HP:0008155)2.79816395
57Joint stiffness (HP:0001387)2.74267913
58Carpal bone hypoplasia (HP:0001498)2.70443032
59Exercise intolerance (HP:0003546)2.67933880
60Hyperphosphaturia (HP:0003109)2.66529738
61Beaking of vertebral bodies (HP:0004568)2.66402438
62Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.62987811
63Respiratory failure (HP:0002878)2.62423284
64Vertebral compression fractures (HP:0002953)2.62372981
65Renal salt wasting (HP:0000127)2.61367702
66Generalized aminoaciduria (HP:0002909)2.59975331
67Hypothermia (HP:0002045)2.59922688
68Lethargy (HP:0001254)2.59378575
69Abnormal protein glycosylation (HP:0012346)2.59295551
70Abnormal glycosylation (HP:0012345)2.59295551
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.59295551
72Abnormal protein N-linked glycosylation (HP:0012347)2.59295551
73Myopathic facies (HP:0002058)2.58496215
74Protrusio acetabuli (HP:0003179)2.58405572
75Abnormality of fatty-acid metabolism (HP:0004359)2.54895415
76Abnormality of renal resorption (HP:0011038)2.54705697
77Premature rupture of membranes (HP:0001788)2.54285497
78Distal upper limb amyotrophy (HP:0007149)2.53401996
79Upper limb amyotrophy (HP:0009129)2.53401996
80Hyperaldosteronism (HP:0000859)2.48645102
81Progressive muscle weakness (HP:0003323)2.46843279
823-Methylglutaconic aciduria (HP:0003535)2.45028292
83Increased serum pyruvate (HP:0003542)2.43607627
84Abnormality of glycolysis (HP:0004366)2.43607627
85Decreased circulating renin level (HP:0003351)2.43025938
86Hand muscle atrophy (HP:0009130)2.42571381
87Metabolic acidosis (HP:0001942)2.41853295
88Hypoplasia of the capital femoral epiphysis (HP:0003090)2.40092087
89Abnormal tarsal ossification (HP:0008369)2.38572138
90Delayed CNS myelination (HP:0002188)2.37741433
91Broad distal phalanx of finger (HP:0009836)2.37506946
92Prolonged neonatal jaundice (HP:0006579)2.34297967
93Truncus arteriosus (HP:0001660)2.33725685
94Abnormality of serum amino acid levels (HP:0003112)2.33189235
95Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.30651349
96Ketosis (HP:0001946)2.30492414
97Ketoacidosis (HP:0001993)2.30120320
98Hypertensive crisis (HP:0100735)2.29629885
99Diaphragmatic weakness (HP:0009113)2.28375989
100Ulnar deviation of the wrist (HP:0003049)2.28275658
101Respiratory difficulties (HP:0002880)2.26860030
102Alkalosis (HP:0001948)2.26589123
103Delayed epiphyseal ossification (HP:0002663)2.26285527
104Reticulocytopenia (HP:0001896)2.26212822
105Renal tubular dysfunction (HP:0000124)2.24311619
106Reduced antithrombin III activity (HP:0001976)2.23856612
107Severe muscular hypotonia (HP:0006829)2.22929572
108Multiple enchondromatosis (HP:0005701)2.22861890
109Type II lissencephaly (HP:0007260)2.21924502
110CNS demyelination (HP:0007305)2.21483904
111Thoracic kyphosis (HP:0002942)2.21102667
112Rectal prolapse (HP:0002035)2.19742047
113Cervical subluxation (HP:0003308)2.19701626
114Microvesicular hepatic steatosis (HP:0001414)2.19437674
115Macrocytic anemia (HP:0001972)2.17802280
116Abnormal urine phosphate concentration (HP:0012599)2.17790322
117Epiphyseal dysplasia (HP:0002656)2.17511881
118Mesangial abnormality (HP:0001966)2.15189572
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14986119
120Abnormality of alanine metabolism (HP:0010916)2.14986119
121Hyperalaninemia (HP:0003348)2.14986119
122Hypoglycemic seizures (HP:0002173)2.13216463
123Back pain (HP:0003418)2.11704698
124Conjugated hyperbilirubinemia (HP:0002908)2.07203885
125Hyperammonemia (HP:0001987)2.06460474
126Exertional dyspnea (HP:0002875)2.06170550
127Palpitations (HP:0001962)2.05647410
128Ovoid vertebral bodies (HP:0003300)2.00767156
129Cerebral hypomyelination (HP:0006808)1.98554675
130Vomiting (HP:0002013)1.97010931
131Severe visual impairment (HP:0001141)1.96859067
132Deep venous thrombosis (HP:0002625)1.96709604
133Flat capital femoral epiphysis (HP:0003370)1.95160935
134Hyponatremia (HP:0002902)1.95143555
135Ileus (HP:0002595)1.93928925
136Abnormality of the thoracic spine (HP:0100711)1.92574690
137Megaloblastic anemia (HP:0001889)1.91994119
138Aplastic anemia (HP:0001915)1.91742733
139Gout (HP:0001997)1.91709149
140Ragged-red muscle fibers (HP:0003200)1.90580743
141Hypoglycemic coma (HP:0001325)1.89480256
142Oral leukoplakia (HP:0002745)1.88594097
143Increased serum ferritin (HP:0003281)1.88331975
144Chronic bronchitis (HP:0004469)1.88268712
145Unilateral renal agenesis (HP:0000122)1.88221434
146Small epiphyses (HP:0010585)1.88215089
147Deformed sella turcica (HP:0002681)1.86506437
148Xanthomatosis (HP:0000991)1.86139239
149Short femoral neck (HP:0100864)1.85148728
150Progressive neurologic deterioration (HP:0002344)1.83649610
151Abnormal epiphyseal ossification (HP:0010656)1.83022630
152Atelectasis (HP:0100750)1.82828082
153Round ear (HP:0100830)1.81799642
154Elfin facies (HP:0004428)1.81468568
155Cardiomegaly (HP:0001640)1.81137724
156Ulnar bowing (HP:0003031)1.79931117
157Bulbar palsy (HP:0001283)1.79473977
158Purpura (HP:0000979)1.79335457
159Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.78478467
160Absent epiphyses (HP:0010577)1.78111938
161Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78111938
162Abnormality of the tricuspid valve (HP:0001702)1.76059315
163Long toe (HP:0010511)1.75786496
164Asymmetric septal hypertrophy (HP:0001670)1.74930895
165Seborrheic dermatitis (HP:0001051)1.73246690
166Coxa vara (HP:0002812)1.73117512
167Abnormality of subcutaneous fat tissue (HP:0001001)1.72621698
168Dysautonomia (HP:0002459)1.71395528
169Decreased subcutaneous fat (HP:0001002)1.70949471
170Flattened epiphyses (HP:0003071)1.70686271
171Biconcave vertebral bodies (HP:0004586)1.70517182
172Tongue fasciculations (HP:0001308)1.70360791
173Mitral stenosis (HP:0001718)1.67758812
174Thin bony cortex (HP:0002753)1.66741845
175Nonimmune hydrops fetalis (HP:0001790)1.66384526
176Bowed forearm bones (HP:0003956)1.65530743
177Bowing of the arm (HP:0006488)1.65530743
178Slender long bone (HP:0003100)1.65368668
179Nuclear cataract (HP:0100018)1.65149322
180High pitched voice (HP:0001620)1.64373715
181Disproportionate tall stature (HP:0001519)1.63976275
182Renovascular hypertension (HP:0100817)1.63163418
183Cerebral aneurysm (HP:0004944)1.62610562

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.76588485
2BUB14.49527610
3TRIB34.27736591
4LMTK23.87745167
5SMG13.41667731
6STK163.40741739
7WEE13.16218673
8MAP3K33.10778419
9NME23.10748160
10VRK22.81829652
11NME12.81697401
12EIF2AK32.50535935
13SIK12.48666389
14ICK2.45723500
15VRK12.03890928
16PRKD22.01235689
17BRSK21.96790167
18EIF2AK11.89021584
19WNK41.79248647
20PKN21.75773217
21MAPKAPK31.74802637
22CCNB11.69700500
23CDK81.61985242
24TLK11.59144848
25MAP2K61.58669692
26MST41.53289220
27PIM21.51391864
28TTN1.49175810
29MAP2K31.40002477
30EEF2K1.38169367
31FLT31.35499229
32LRRK21.33937533
33STK391.26784628
34TESK21.26185002
35RIPK11.21855126
36TBK11.20645582
37PRKG21.18866352
38PASK1.18617208
39MAP3K111.18447281
40NEK11.17266856
41RPS6KB21.16884089
42LIMK11.14530531
43BRSK11.13693253
44SRPK11.12131820
45MST1R1.11472039
46TSSK61.10869527
47ERN11.09699129
48GRK11.06317224
49OXSR11.04194987
50HIPK21.01898544
51CDK191.00509175
52MAPK150.97960036
53IRAK30.96974914
54MYLK0.96276910
55BMPR1B0.94996407
56STK100.91413448
57ADRBK20.90906431
58PHKG10.88573278
59PHKG20.88573278
60FGFR40.88341129
61AURKA0.87754158
62RPS6KA60.85935746
63OBSCN0.85076950
64PTK60.84070684
65MAP2K20.80727071
66RPS6KA20.79286503
67RPS6KL10.79251316
68RPS6KC10.79251316
69PTK20.78924716
70MAPK110.78272858
71ACVR1B0.77750110
72JAK30.76906142
73CAMKK20.76145131
74MTOR0.75648347
75CAMK1D0.75339336
76TESK10.74134402
77BTK0.73187801
78BMX0.71615012
79ARAF0.71555658
80PAK40.70383071
81TAF10.70165201
82ILK0.69975606
83TYRO30.69784087
84AURKB0.69373236
85CHUK0.66829844
86STK240.66649828
87DAPK10.66217893
88IRAK40.64994734
89MAP4K10.64255419
90INSRR0.63854807
91TEC0.63032628
92IKBKB0.62430090
93KDR0.61696360
94FRK0.61562739
95CSNK2A10.60985218
96PDPK10.60580669
97TAOK20.60359712
98NTRK10.60079482
99CDK90.59085214
100KIT0.58265454
101MKNK10.57633427
102SCYL20.56629380
103PLK40.56129564
104DYRK1B0.55871716
105IRAK10.55794311
106CDK70.55701437
107ZAP700.54648939
108EPHB20.54565776
109MUSK0.54369273
110PINK10.53799636
111RPS6KA50.53301771
112TAOK30.52845307
113TGFBR10.52617345
114ABL20.51085645
115WNK30.50241281
116MAP3K20.49926063
117CSNK2A20.49815809
118MAPKAPK20.49792460
119DAPK30.49588087
120MAPK40.48821738
121MAP3K80.48492736
122EIF2AK20.48361212
123PLK10.48198254
124MAPKAPK50.47293211
125TTK0.46449222
126MAP2K10.46328495
127MAP3K70.46317206
128DYRK20.45899679
129MAP3K10.45524272
130GRK60.44355382
131EPHA20.44118576
132PIK3CG0.43851573
133CHEK20.43416956
134PLK30.42736949
135TIE10.42650682
136PAK10.42064635
137DDR20.41754203
138BRAF0.41750711
139CDC42BPA0.41438001
140PRKCI0.40927943
141AKT20.40872244
142PDK30.40862848
143PDK40.40862848
144CLK10.40283223
145ZAK0.36633462
146PRKCH0.36422712
147RPS6KA10.36310880
148ADRBK10.36293831
149CDK40.35801568
150MAP4K20.34653560
151MKNK20.33738932
152TNK20.33601467
153CDK120.33506763
154PRKD30.33100851
155NLK0.32295547
156CSNK1G30.31481603
157TNIK0.28669915
158CSF1R0.28166147
159NEK20.27870332
160CAMK2D0.27233705

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.66554201
2Ribosome_Homo sapiens_hsa030103.32692311
3Protein export_Homo sapiens_hsa030603.29236759
4Oxidative phosphorylation_Homo sapiens_hsa001902.99121545
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.97705782
6Parkinsons disease_Homo sapiens_hsa050122.72852136
7Sulfur metabolism_Homo sapiens_hsa009202.61365883
8Folate biosynthesis_Homo sapiens_hsa007902.57230870
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.53030782
10Proteasome_Homo sapiens_hsa030502.51841382
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.43777023
12DNA replication_Homo sapiens_hsa030302.39855020
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.32895343
14RNA polymerase_Homo sapiens_hsa030202.26037863
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06130496
16Sulfur relay system_Homo sapiens_hsa041222.03237508
17Pyrimidine metabolism_Homo sapiens_hsa002402.02938476
18Mismatch repair_Homo sapiens_hsa034301.85233410
19Propanoate metabolism_Homo sapiens_hsa006401.83475695
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83084639
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80720679
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.75567592
23Huntingtons disease_Homo sapiens_hsa050161.75267817
24Alzheimers disease_Homo sapiens_hsa050101.72282664
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68787686
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68695929
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67371126
28Base excision repair_Homo sapiens_hsa034101.67064610
29Bladder cancer_Homo sapiens_hsa052191.66323962
30One carbon pool by folate_Homo sapiens_hsa006701.63552295
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.60608241
32Carbon metabolism_Homo sapiens_hsa012001.55525167
33Fatty acid elongation_Homo sapiens_hsa000621.53767416
34Pyruvate metabolism_Homo sapiens_hsa006201.50989837
35Peroxisome_Homo sapiens_hsa041461.45253970
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45197241
37Fatty acid degradation_Homo sapiens_hsa000711.44135655
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.40635659
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40363772
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29465008
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29191340
42Pentose phosphate pathway_Homo sapiens_hsa000301.28685482
43Nucleotide excision repair_Homo sapiens_hsa034201.28325539
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.27704091
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.27128700
46Biosynthesis of amino acids_Homo sapiens_hsa012301.25507575
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23148294
48Glutathione metabolism_Homo sapiens_hsa004801.22065324
49Homologous recombination_Homo sapiens_hsa034401.19557683
50Other glycan degradation_Homo sapiens_hsa005111.18848784
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.16937309
52N-Glycan biosynthesis_Homo sapiens_hsa005101.16161868
53Fructose and mannose metabolism_Homo sapiens_hsa000511.13531264
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10871108
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09953359
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09639994
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08819016
58Starch and sucrose metabolism_Homo sapiens_hsa005001.07806256
59Galactose metabolism_Homo sapiens_hsa000521.07642805
60Arginine and proline metabolism_Homo sapiens_hsa003301.07488029
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06759444
62Purine metabolism_Homo sapiens_hsa002301.06589435
63Non-homologous end-joining_Homo sapiens_hsa034501.05626052
64Metabolic pathways_Homo sapiens_hsa011001.01484944
65Spliceosome_Homo sapiens_hsa030401.00402788
66Selenocompound metabolism_Homo sapiens_hsa004500.97629321
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97350111
68Butanoate metabolism_Homo sapiens_hsa006500.97212584
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.94216962
70Notch signaling pathway_Homo sapiens_hsa043300.93363813
71beta-Alanine metabolism_Homo sapiens_hsa004100.92512424
72Fatty acid metabolism_Homo sapiens_hsa012120.92380583
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90510991
74RNA transport_Homo sapiens_hsa030130.88538871
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87868908
76Tryptophan metabolism_Homo sapiens_hsa003800.87583351
77Vitamin B6 metabolism_Homo sapiens_hsa007500.86016001
78ABC transporters_Homo sapiens_hsa020100.81674522
79Vibrio cholerae infection_Homo sapiens_hsa051100.80890163
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80241049
81Sphingolipid metabolism_Homo sapiens_hsa006000.79114851
82Cardiac muscle contraction_Homo sapiens_hsa042600.77959624
83ECM-receptor interaction_Homo sapiens_hsa045120.73648736
84Histidine metabolism_Homo sapiens_hsa003400.73473268
85Acute myeloid leukemia_Homo sapiens_hsa052210.72868507
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69694292
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69416523
88Vitamin digestion and absorption_Homo sapiens_hsa049770.66026488
89Steroid biosynthesis_Homo sapiens_hsa001000.65771958
90Arachidonic acid metabolism_Homo sapiens_hsa005900.65694724
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.64856384
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64185021
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63301251
94Chemical carcinogenesis_Homo sapiens_hsa052040.62829494
95Lysine degradation_Homo sapiens_hsa003100.61951776
96Retinol metabolism_Homo sapiens_hsa008300.60809437
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60347793
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60288078
99Tyrosine metabolism_Homo sapiens_hsa003500.57608144
100VEGF signaling pathway_Homo sapiens_hsa043700.56576413
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55843625
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.55782856
103RNA degradation_Homo sapiens_hsa030180.55765604
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.52400778
105Cell cycle_Homo sapiens_hsa041100.51130436
106Prion diseases_Homo sapiens_hsa050200.49274559
107Lysosome_Homo sapiens_hsa041420.49069510
108Collecting duct acid secretion_Homo sapiens_hsa049660.46772563
109Insulin resistance_Homo sapiens_hsa049310.44657331
110TNF signaling pathway_Homo sapiens_hsa046680.44143939
111AMPK signaling pathway_Homo sapiens_hsa041520.42515793
112Complement and coagulation cascades_Homo sapiens_hsa046100.41499826
113Fat digestion and absorption_Homo sapiens_hsa049750.39636142
114Basal transcription factors_Homo sapiens_hsa030220.39403459
115Hepatitis C_Homo sapiens_hsa051600.39041709
116PPAR signaling pathway_Homo sapiens_hsa033200.37947484
117Linoleic acid metabolism_Homo sapiens_hsa005910.37561314
118Phenylalanine metabolism_Homo sapiens_hsa003600.36029043
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.35908387
120Chronic myeloid leukemia_Homo sapiens_hsa052200.35816546
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34083109
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32756316
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29914405
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29822454
125Basal cell carcinoma_Homo sapiens_hsa052170.29563972
126Glycerolipid metabolism_Homo sapiens_hsa005610.29460754
127Small cell lung cancer_Homo sapiens_hsa052220.28761036
128Regulation of autophagy_Homo sapiens_hsa041400.27271619
129Apoptosis_Homo sapiens_hsa042100.27121774
130Protein digestion and absorption_Homo sapiens_hsa049740.26837444
131Arginine biosynthesis_Homo sapiens_hsa002200.23813325
132Fanconi anemia pathway_Homo sapiens_hsa034600.23218000
133Insulin signaling pathway_Homo sapiens_hsa049100.23111239
134Nitrogen metabolism_Homo sapiens_hsa009100.23046093
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.21765023

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