OGFR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.21977998
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.21977998
3antigen processing and presentation of endogenous antigen (GO:0019883)5.43941653
4response to peptidoglycan (GO:0032494)4.41421103
5negative regulation of cell killing (GO:0031342)4.23697176
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.23697176
7positive regulation of gamma-delta T cell activation (GO:0046645)4.10997338
8macrophage activation involved in immune response (GO:0002281)4.08398454
9positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.84869873
10detection of other organism (GO:0098543)3.76510113
11detection of bacterium (GO:0016045)3.71670176
12regulation of gamma-delta T cell differentiation (GO:0045586)3.68482493
13regulation of type I interferon-mediated signaling pathway (GO:0060338)3.62306070
14neutrophil activation involved in immune response (GO:0002283)3.59653753
15germinal center formation (GO:0002467)3.51188982
16antigen processing and presentation via MHC class Ib (GO:0002475)3.50356197
17lipopolysaccharide-mediated signaling pathway (GO:0031663)3.49194058
18pentose-phosphate shunt (GO:0006098)3.38118109
19regulation of gamma-delta T cell activation (GO:0046643)3.37803805
20positive regulation of interferon-alpha production (GO:0032727)3.31114013
21detection of external biotic stimulus (GO:0098581)3.27840561
22maternal placenta development (GO:0001893)3.26101403
23positive regulation of Cdc42 GTPase activity (GO:0043089)3.24384269
24response to type I interferon (GO:0034340)3.17748310
25DNA unwinding involved in DNA replication (GO:0006268)3.17542276
26Arp2/3 complex-mediated actin nucleation (GO:0034314)3.16954727
27leukocyte aggregation (GO:0070486)3.16619546
28low-density lipoprotein particle clearance (GO:0034383)3.14416762
29regulation of T-helper 2 cell differentiation (GO:0045628)3.14206058
30type I interferon signaling pathway (GO:0060337)3.12006176
31cellular response to type I interferon (GO:0071357)3.12006176
32regulation of interferon-alpha production (GO:0032647)3.11119300
33detection of molecule of bacterial origin (GO:0032490)3.09358142
34mannose metabolic process (GO:0006013)3.05579839
35NADPH regeneration (GO:0006740)3.05130256
36regulation of cholesterol storage (GO:0010885)3.03727846
37positive regulation of histone deacetylation (GO:0031065)3.03439824
38T cell apoptotic process (GO:0070231)3.01704787
39defense response to protozoan (GO:0042832)2.95305723
40negative regulation of erythrocyte differentiation (GO:0045647)2.95183991
41regulation of interleukin-12 biosynthetic process (GO:0045075)2.92540468
42NIK/NF-kappaB signaling (GO:0038061)2.92342436
43morphogenesis of an endothelium (GO:0003159)2.91216961
44endothelial tube morphogenesis (GO:0061154)2.91216961
45regulation of leukocyte degranulation (GO:0043300)2.90382284
46modulation by symbiont of host cellular process (GO:0044068)2.89947749
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.89748999
48positive regulation by organism of defense response of other organism involved in symbiotic interact2.89748999
49modulation by symbiont of host immune response (GO:0052553)2.89748999
50positive regulation by symbiont of host defense response (GO:0052509)2.89748999
51modulation by symbiont of host defense response (GO:0052031)2.89748999
52modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.89748999
53response to protozoan (GO:0001562)2.88934692
54JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.88134174
55regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87127968
56detection of biotic stimulus (GO:0009595)2.86688146
57regulation of mast cell degranulation (GO:0043304)2.85835287
58viral transcription (GO:0019083)2.83786742
59epithelial cell differentiation involved in prostate gland development (GO:0060742)2.82851310
60protein localization to endosome (GO:0036010)2.82274007
61folic acid-containing compound biosynthetic process (GO:0009396)2.81646618
62regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.81379450
63positive regulation of natural killer cell differentiation (GO:0032825)2.81249945
64response to interferon-alpha (GO:0035455)2.81051571
65regulation of myeloid leukocyte mediated immunity (GO:0002886)2.80886588
66regulation of interferon-beta biosynthetic process (GO:0045357)2.77274901
67natural killer cell differentiation (GO:0001779)2.76379027
68response to host immune response (GO:0052572)2.73588085
69response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.73588085
70positive regulation of type 2 immune response (GO:0002830)2.73540449
71T-helper 1 type immune response (GO:0042088)2.73392561
72myeloid dendritic cell activation (GO:0001773)2.71731173
73apoptotic cell clearance (GO:0043277)2.71219600
74positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.70323666
75immunoglobulin mediated immune response (GO:0016064)2.67539507
76translational termination (GO:0006415)2.66958265
77macrophage activation (GO:0042116)2.66913809
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.66660783
79response to host (GO:0075136)2.66660783
80response to host defenses (GO:0052200)2.66660783
81regulation of T-helper 1 cell differentiation (GO:0045625)2.64598676
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64260208
83regulation of type 2 immune response (GO:0002828)2.63454326
84cellular response to virus (GO:0098586)2.63256266
85regulation of response to interferon-gamma (GO:0060330)2.63232756
86granulocyte activation (GO:0036230)2.61825281
87response to laminar fluid shear stress (GO:0034616)2.61095820
883-UTR-mediated mRNA stabilization (GO:0070935)2.61064742
89negative regulation of leukocyte mediated immunity (GO:0002704)2.59639277
90regulation of T cell tolerance induction (GO:0002664)2.59537042
91positive thymic T cell selection (GO:0045059)2.59374488
92myeloid cell activation involved in immune response (GO:0002275)2.59149186
93regulation of translational fidelity (GO:0006450)2.57546187
94regulation of protein heterodimerization activity (GO:0043497)2.55847805
95positive regulation of cellular amide metabolic process (GO:0034250)2.55511681
96negative regulation of lymphocyte mediated immunity (GO:0002707)2.54838589
97barbed-end actin filament capping (GO:0051016)2.54255857
98ribosomal small subunit assembly (GO:0000028)2.52969099
99positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.52939633
100cellular extravasation (GO:0045123)2.52390115
101negative regulation of type 2 immune response (GO:0002829)2.52155845
102translational elongation (GO:0006414)2.51679504
103activation of MAPKKK activity (GO:0000185)2.49963235
104regulation of mast cell activation involved in immune response (GO:0033006)2.49806852
105negative regulation of toll-like receptor signaling pathway (GO:0034122)2.49511365
106regulation of antigen processing and presentation (GO:0002577)2.49141229
107modulation by virus of host process (GO:0019054)2.48940161
108lymphocyte apoptotic process (GO:0070227)2.48715412
109positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.48704632
110regulation of necroptotic process (GO:0060544)2.48473420
111negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.48197032
112positive regulation of B cell differentiation (GO:0045579)2.47058342
113neutrophil activation (GO:0042119)2.46667712
114negative regulation of innate immune response (GO:0045824)2.46455095
115COPI coating of Golgi vesicle (GO:0048205)2.46376997
116Golgi transport vesicle coating (GO:0048200)2.46376997
117cellular response to interferon-alpha (GO:0035457)2.45731487
118negative regulation of cell size (GO:0045792)2.44773418
119negative regulation of myeloid cell apoptotic process (GO:0033033)2.44412357
120respiratory burst (GO:0045730)2.43392356
121regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.43159996
122sexual reproduction (GO:0019953)2.42940123
123negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.41934088
124negative regulation of viral release from host cell (GO:1902187)2.40884251
125positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.40743685
126regulation of vitamin D biosynthetic process (GO:0060556)2.40626774
127regulation of cholesterol homeostasis (GO:2000188)2.40412139
128regulation of fatty acid beta-oxidation (GO:0031998)2.40355443
129positive regulation of protein deacetylation (GO:0090312)2.39554576
130negative regulation of T cell mediated immunity (GO:0002710)2.39382879
131interferon-gamma secretion (GO:0072643)2.38682923
132regulation of superoxide anion generation (GO:0032928)2.38668413
133positive regulation of antigen processing and presentation (GO:0002579)2.38507027
134negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.36763452
135B cell mediated immunity (GO:0019724)2.36329290
136heterochromatin organization (GO:0070828)2.36113976
1374-hydroxyproline metabolic process (GO:0019471)2.33573888
138regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.33222873
139nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.30395657
140response to muramyl dipeptide (GO:0032495)2.26408562
141positive regulation of triglyceride biosynthetic process (GO:0010867)2.24778520
142positive regulation of nuclease activity (GO:0032075)2.23871450
143apoptotic process involved in morphogenesis (GO:0060561)2.22545485
144negative regulation of interleukin-12 production (GO:0032695)2.22348995
145leukocyte apoptotic process (GO:0071887)2.21496430
146basement membrane organization (GO:0071711)2.21296110
147myeloid cell homeostasis (GO:0002262)2.20777952
148activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.19998909
149positive regulation of interferon-beta production (GO:0032728)2.19806127
150interferon-gamma-mediated signaling pathway (GO:0060333)2.19768261
151positive regulation of lipid storage (GO:0010884)2.18262860
152negative regulation of fibrinolysis (GO:0051918)2.17882381
153activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.17791946
154peptidyl-lysine dimethylation (GO:0018027)2.17728043
155negative regulation of cytokine production involved in immune response (GO:0002719)2.16755631
156positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.16162671
157myeloid dendritic cell differentiation (GO:0043011)2.14545847
158platelet aggregation (GO:0070527)2.13355043
159viral life cycle (GO:0019058)2.12494445
160RNA stabilization (GO:0043489)2.12381419
161mRNA stabilization (GO:0048255)2.12381419
162regulation of nuclease activity (GO:0032069)2.11779257
163cell adhesion mediated by integrin (GO:0033627)2.10841509
164pinocytosis (GO:0006907)2.10562605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.34365623
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.11531621
3MYC_22102868_ChIP-Seq_BL_Human3.11393043
4E2F7_22180533_ChIP-Seq_HELA_Human3.06691550
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.96543428
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92095659
7VDR_21846776_ChIP-Seq_THP-1_Human2.68255499
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.52827674
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29499761
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.28131178
11ELK3_25401928_ChIP-Seq_HUVEC_Human2.20091663
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.19506437
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.10047459
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10004167
15MAF_26560356_Chip-Seq_TH1_Human1.99465380
16* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99325212
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91115181
18TCF7_22412390_ChIP-Seq_EML_Mouse1.89578397
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86928916
20KDM2B_26808549_Chip-Seq_DND41_Human1.85055216
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82804792
22CLOCK_20551151_ChIP-Seq_293T_Human1.80376071
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79041576
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78565794
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78284839
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.78248204
27UTX_26944678_Chip-Seq_JUKART_Human1.77846603
28* LXR_22292898_ChIP-Seq_THP-1_Human1.77830959
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.75797117
30* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73883138
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64676620
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64513126
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63228522
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62386086
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61178084
36VDR_24763502_ChIP-Seq_THP-1_Human1.58903317
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.58694002
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.57687479
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57458766
40KDM2B_26808549_Chip-Seq_K562_Human1.54592382
41* ESR2_21235772_ChIP-Seq_MCF-7_Human1.54041524
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52561629
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49951716
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49233960
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48605838
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46554610
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41982763
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41303492
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41128349
50CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40627051
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40572507
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.40520026
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38508306
54MAF_26560356_Chip-Seq_TH2_Human1.38329672
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38269793
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36855047
57RACK7_27058665_Chip-Seq_MCF-7_Human1.36686414
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36438931
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35921454
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.35538988
61* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34105026
62GATA1_19941827_ChIP-Seq_MEL_Mouse1.33980451
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.32839547
64MYB_26560356_Chip-Seq_TH2_Human1.32384842
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31817950
66ATF3_27146783_Chip-Seq_COLON_Human1.31107683
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30647755
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30228096
69XRN2_22483619_ChIP-Seq_HELA_Human1.28133972
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26610392
71MYB_26560356_Chip-Seq_TH1_Human1.25607411
72SMC4_20622854_ChIP-Seq_HELA_Human1.25538451
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24362268
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24179620
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21943215
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.21450136
77SCL_19346495_ChIP-Seq_HPC-7_Human1.21224241
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20643196
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20460069
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20028078
81* SPI1_23547873_ChIP-Seq_NB4_Human1.19707619
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17881378
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17072176
84MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17065598
85NCOR1_26117541_ChIP-Seq_K562_Human1.16699129
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15885252
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15470449
88CIITA_25753668_ChIP-Seq_RAJI_Human1.14982431
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.14307842
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13993699
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13760369
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12862464
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12640101
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11689322
95* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11035894
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10538265
97FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10298472
98TFEB_21752829_ChIP-Seq_HELA_Human1.09334564
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.07407111
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07134677
101CREB1_26743006_Chip-Seq_LNCaP_Human1.07114796
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05504435
103KDM2B_26808549_Chip-Seq_JURKAT_Human1.05500928
104LXR_22158963_ChIP-Seq_LIVER_Mouse1.05448573
105GATA1_19941826_ChIP-Seq_K562_Human1.05424779
106ZNF263_19887448_ChIP-Seq_K562_Human1.03868752
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03707554
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03209450
109* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02968199
110SPI1_23127762_ChIP-Seq_K562_Human1.02564427
111* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02277899
112RUNX_20019798_ChIP-Seq_JUKART_Human1.01786011
113ERG_21242973_ChIP-ChIP_JURKAT_Human1.01093363
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99982842
115BCL6_27268052_Chip-Seq_Bcells_Human0.99810644
116RUNX1_27514584_Chip-Seq_MCF-7_Human0.99196256
117* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98673013
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98357101
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98123538
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97325122
121* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97273696
122P68_20966046_ChIP-Seq_HELA_Human0.96341460
123BCOR_27268052_Chip-Seq_Bcells_Human0.96324014
124GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96292923
125CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96168342
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96166492
127MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94928462
128KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94442890
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94433747
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93445528
131NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91282604
132FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91102191

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.86770000
2MP0005451_abnormal_body_composition2.92770292
3MP0003303_peritoneal_inflammation2.84156889
4MP0009840_abnormal_foam_cell2.80325712
5MP0000685_abnormal_immune_system2.45332593
6MP0010352_gastrointestinal_tract_polyps2.38405613
7MP0008438_abnormal_cutaneous_collagen2.37821400
8MP0003436_decreased_susceptibility_to2.36640575
9MP0003300_gastrointestinal_ulcer2.32991588
10MP0001835_abnormal_antigen_presentation2.23336916
11MP0009278_abnormal_bone_marrow2.16053124
12MP0003191_abnormal_cellular_cholesterol2.09819057
13MP0008260_abnormal_autophagy2.04177113
14MP0005076_abnormal_cell_differentiation1.98567990
15MP0009785_altered_susceptibility_to1.80493175
16MP0004510_myositis1.75272945
17MP0001790_abnormal_immune_system1.69001927
18MP0005387_immune_system_phenotype1.69001927
19MP0001800_abnormal_humoral_immune1.68295063
20MP0003075_altered_response_to1.67318853
21MP0003566_abnormal_cell_adhesion1.67011060
22MP0005360_urolithiasis1.66870296
23MP0004947_skin_inflammation1.65395914
24MP0005023_abnormal_wound_healing1.60932185
25MP0005025_abnormal_response_to1.59220385
26MP0002452_abnormal_antigen_presenting1.59085678
27MP0004808_abnormal_hematopoietic_stem1.56817313
28MP0005058_abnormal_lysosome_morphology1.52822475
29MP0005000_abnormal_immune_tolerance1.52597333
30MP0010307_abnormal_tumor_latency1.46918963
31MP0005464_abnormal_platelet_physiology1.44650150
32MP0001545_abnormal_hematopoietic_system1.43825182
33MP0005397_hematopoietic_system_phenotyp1.43825182
34MP0002723_abnormal_immune_serum1.43546792
35MP0009333_abnormal_splenocyte_physiolog1.43264087
36MP0002419_abnormal_innate_immunity1.39582315
37MP0002398_abnormal_bone_marrow1.38856732
38MP0001819_abnormal_immune_cell1.38589696
39MP0002166_altered_tumor_susceptibility1.38494715
40MP0006054_spinal_hemorrhage1.37376607
41MP0002420_abnormal_adaptive_immunity1.37364781
42MP0001533_abnormal_skeleton_physiology1.36316368
43MP0006082_CNS_inflammation1.34745550
44MP0005310_abnormal_salivary_gland1.33149810
45MP0001849_ear_inflammation1.32911824
46MP0003183_abnormal_peptide_metabolism1.31130624
47MP0005083_abnormal_biliary_tract1.31023166
48MP0009764_decreased_sensitivity_to1.28783715
49MP0010155_abnormal_intestine_physiology1.26434584
50MP0000858_altered_metastatic_potential1.26138692
51MP0002139_abnormal_hepatobiliary_system1.25978930
52MP0002405_respiratory_system_inflammati1.25625567
53MP0000733_abnormal_muscle_development1.25274793
54MP0002722_abnormal_immune_system1.23702865
55MP0000716_abnormal_immune_system1.23089155
56MP0003091_abnormal_cell_migration1.22217446
57MP0005671_abnormal_response_to1.21995738
58MP0004858_abnormal_nervous_system1.21509210
59MP0000689_abnormal_spleen_morphology1.18213516
60MP0002396_abnormal_hematopoietic_system1.16734149
61MP0003448_altered_tumor_morphology1.16701279
62MP0010234_abnormal_vibrissa_follicle1.16640174
63MP0002429_abnormal_blood_cell1.16495092
64MP0003763_abnormal_thymus_physiology1.15459270
65MP0001853_heart_inflammation1.14449473
66MP0005166_decreased_susceptibility_to1.14141072
67MP0003329_amyloid_beta_deposits1.14024894
68MP0003690_abnormal_glial_cell1.14023555
69MP0003279_aneurysm1.13682466
70MP0001845_abnormal_inflammatory_respons1.12831191
71MP0008469_abnormal_protein_level1.08500342
72MP0000609_abnormal_liver_physiology1.06819078
73MP0000703_abnormal_thymus_morphology1.04546553
74MP0000598_abnormal_liver_morphology1.03526860
75MP0001958_emphysema1.03034509
76MP0003172_abnormal_lysosome_physiology1.02566456
77MP0000604_amyloidosis1.02232353
78MP0003866_abnormal_defecation1.01567959
79MP0001915_intracranial_hemorrhage1.01309860
80MP0002148_abnormal_hypersensitivity_rea1.00831296
81MP0002254_reproductive_system_inflammat0.99999317
82MP0003828_pulmonary_edema0.99874344
83MP0001851_eye_inflammation0.97061508
84MP0001730_embryonic_growth_arrest0.96508052
85MP0005666_abnormal_adipose_tissue0.94734741
86MP0000343_altered_response_to0.94281372
87MP0002006_tumorigenesis0.94221867
88MP0004381_abnormal_hair_follicle0.92624472
89MP0000465_gastrointestinal_hemorrhage0.92579424
90MP0003221_abnormal_cardiomyocyte_apopto0.92519134
91MP0002933_joint_inflammation0.92269207
92MP0004197_abnormal_fetal_growth/weight/0.90021899
93MP0004185_abnormal_adipocyte_glucose0.89576067
94MP0001663_abnormal_digestive_system0.87414523
95MP0000767_abnormal_smooth_muscle0.86719401
96MP0005164_abnormal_response_to0.86697757
97MP0003453_abnormal_keratinocyte_physiol0.86494993
98MP0001348_abnormal_lacrimal_gland0.85012586
99MP0000490_abnormal_crypts_of0.84725682
100MP0003077_abnormal_cell_cycle0.84343279
101MP0004883_abnormal_blood_vessel0.83747739
102MP0010368_abnormal_lymphatic_system0.83485331
103MP0008874_decreased_physiological_sensi0.82926897
104MP0002877_abnormal_melanocyte_morpholog0.82824735
105MP0010329_abnormal_lipoprotein_level0.82536829
106MP0002019_abnormal_tumor_incidence0.80494479
107MP0005275_abnormal_skin_tensile0.80361460
108MP0005319_abnormal_enzyme/_coenzyme0.78336108
109MP0008961_abnormal_basal_metabolism0.77332600
110MP0005390_skeleton_phenotype0.76919705
111MP0003724_increased_susceptibility_to0.76844848
112MP0002998_abnormal_bone_remodeling0.76542189
113MP0008004_abnormal_stomach_pH0.76374489
114MP0002332_abnormal_exercise_endurance0.76357749
115MP0002089_abnormal_postnatal_growth/wei0.76294890
116MP0002138_abnormal_hepatobiliary_system0.75918218
117MP0000350_abnormal_cell_proliferation0.75076550
118MP0002132_abnormal_respiratory_system0.74896205
119MP0010630_abnormal_cardiac_muscle0.74123486
120MP0002088_abnormal_embryonic_growth/wei0.73746817
121MP0002086_abnormal_extraembryonic_tissu0.73683193
122MP0009763_increased_sensitivity_to0.73347771
123MP0001873_stomach_inflammation0.73254120
124MP0005375_adipose_tissue_phenotype0.72877188
125MP0003795_abnormal_bone_structure0.72661720
126MP0000249_abnormal_blood_vessel0.71665514
127MP0003806_abnormal_nucleotide_metabolis0.71078835
128MP0003656_abnormal_erythrocyte_physiolo0.69728681
129MP0000678_abnormal_parathyroid_gland0.69593305

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)3.70383977
2Abnormality of liposaccharide metabolism (HP:0010968)3.70383977
3Abnormality of glycosphingolipid metabolism (HP:0004343)3.70383977
4Orchitis (HP:0100796)3.62649658
5Chronic otitis media (HP:0000389)3.62298681
6Protrusio acetabuli (HP:0003179)3.60951315
7Cerebral aneurysm (HP:0004944)3.33334612
8Optic neuritis (HP:0100653)3.21336387
9Retrobulbar optic neuritis (HP:0100654)3.21336387
10Dysostosis multiplex (HP:0000943)3.21333509
11Elevated erythrocyte sedimentation rate (HP:0003565)3.19905626
12Abnormality of the nasal mucosa (HP:0000433)3.01457009
13Peritonitis (HP:0002586)2.99214183
14Loss of speech (HP:0002371)2.98388670
15Nasal polyposis (HP:0100582)2.97276903
16Obstructive lung disease (HP:0006536)2.80003933
17Chronic obstructive pulmonary disease (HP:0006510)2.80003933
18Eczematoid dermatitis (HP:0000976)2.78530663
19Gingivitis (HP:0000230)2.78366014
20Increased IgE level (HP:0003212)2.76651115
21Hyperacusis (HP:0010780)2.71292782
22Increased density of long bones (HP:0006392)2.67819312
23Deep venous thrombosis (HP:0002625)2.65142844
24Gastrointestinal infarctions (HP:0005244)2.61109334
25Meningitis (HP:0001287)2.59068990
26Shallow orbits (HP:0000586)2.59060951
27Abnormality of polysaccharide metabolism (HP:0011012)2.55705021
28Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55705021
29Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55705021
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.52552935
31Stomatitis (HP:0010280)2.51640868
32Urinary glycosaminoglycan excretion (HP:0003541)2.51136815
33Mucopolysacchariduria (HP:0008155)2.51136815
34Recurrent skin infections (HP:0001581)2.50941451
35Interstitial pulmonary disease (HP:0006530)2.50836969
36Amyloidosis (HP:0011034)2.46335599
37Purpura (HP:0000979)2.45668562
38Vasculitis (HP:0002633)2.41001911
39Axonal loss (HP:0003447)2.37526789
40Cellulitis (HP:0100658)2.35486608
41Hematochezia (HP:0002573)2.35181619
42Vertebral compression fractures (HP:0002953)2.34683549
43Spastic diplegia (HP:0001264)2.32392185
44Aortic aneurysm (HP:0004942)2.31561168
45Hemorrhage of the eye (HP:0011885)2.31399389
46Premature rupture of membranes (HP:0001788)2.31149291
47Upper limb amyotrophy (HP:0009129)2.29721162
48Distal upper limb amyotrophy (HP:0007149)2.29721162
49Autoimmune thrombocytopenia (HP:0001973)2.29541733
50Hand muscle atrophy (HP:0009130)2.29088334
51Thrombocytosis (HP:0001894)2.28272611
52Malnutrition (HP:0004395)2.27878530
53Recurrent bronchitis (HP:0002837)2.24275750
54Dilatation of the ascending aorta (HP:0005111)2.23373324
55Keratoconjunctivitis sicca (HP:0001097)2.21968633
56Ulnar bowing (HP:0003031)2.21870119
57Recurrent viral infections (HP:0004429)2.21265426
58Vacuolated lymphocytes (HP:0001922)2.18646337
59Gastrointestinal stroma tumor (HP:0100723)2.18529936
60Cervical subluxation (HP:0003308)2.17617754
61Neurofibrillary tangles (HP:0002185)2.17436199
62Myocardial infarction (HP:0001658)2.17129334
63Nuclear cataract (HP:0100018)2.17066995
64Aneurysm (HP:0002617)2.15416653
65Pulmonary infiltrates (HP:0002113)2.15070546
66Neuronal loss in central nervous system (HP:0002529)2.14522503
67Glomerulonephritis (HP:0000099)2.14367855
68Mitral valve prolapse (HP:0001634)2.14289138
69Spontaneous hematomas (HP:0007420)2.14157496
70Polycythemia (HP:0001901)2.12677596
71Recurrent abscess formation (HP:0002722)2.11376313
72Polygenic inheritance (HP:0010982)2.11068929
73Urticaria (HP:0001025)2.10640774
74Multiple enchondromatosis (HP:0005701)2.10229659
75Broad face (HP:0000283)2.09405485
76Abnormality of the peritoneum (HP:0002585)2.06925321
77J-shaped sella turcica (HP:0002680)2.06658221
78Recurrent bacterial skin infections (HP:0005406)2.05252695
79Ankle contracture (HP:0006466)2.04903349
80Colitis (HP:0002583)2.04748241
81Emphysema (HP:0002097)2.03960438
82Recurrent gram-negative bacterial infections (HP:0005420)2.03560249
83Subacute progressive viral hepatitis (HP:0006572)2.00581056
84Gastrointestinal inflammation (HP:0004386)2.00449072
85Cerebral inclusion bodies (HP:0100314)1.99966995
86Segmental peripheral demyelination/remyelination (HP:0003481)1.98627097
87Genu recurvatum (HP:0002816)1.97000824
88Ectopia lentis (HP:0001083)1.95406673
89Keratoconjunctivitis (HP:0001096)1.94205742
90Radial bowing (HP:0002986)1.93604564
91Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93524963
92Short 4th metacarpal (HP:0010044)1.93524963
93Hemoptysis (HP:0002105)1.93499610
94Obstructive sleep apnea (HP:0002870)1.93083496
95Thin bony cortex (HP:0002753)1.92966993
96Hepatosplenomegaly (HP:0001433)1.91696732
97Systemic lupus erythematosus (HP:0002725)1.90984568
98Arterial thrombosis (HP:0004420)1.90246896
99Encephalitis (HP:0002383)1.89865560
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89573485
101Xanthomatosis (HP:0000991)1.89242827
102Pathologic fracture (HP:0002756)1.88871343
103Bladder diverticulum (HP:0000015)1.88612286
104Recurrent cutaneous fungal infections (HP:0011370)1.88571146
105Chronic mucocutaneous candidiasis (HP:0002728)1.88571146
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87944097
107Petechiae (HP:0000967)1.87786304
108Broad metatarsal (HP:0001783)1.87329947
109Abnormality of the Achilles tendon (HP:0005109)1.85049956
110Pustule (HP:0200039)1.84638101
111Verrucae (HP:0200043)1.84295612
112Papilloma (HP:0012740)1.84295612
113Epistaxis (HP:0000421)1.84039315
114Persistence of primary teeth (HP:0006335)1.83831622
115Disinhibition (HP:0000734)1.83609519
116Prolonged bleeding time (HP:0003010)1.82973490
117Bone pain (HP:0002653)1.82826936
118Increased serum ferritin (HP:0003281)1.82749678
119Slow saccadic eye movements (HP:0000514)1.82626989
120Bicuspid aortic valve (HP:0001647)1.82619011
121Recurrent fungal infections (HP:0002841)1.82223112
122Esophageal varix (HP:0002040)1.81483019
123Myositis (HP:0100614)1.81455234
124Achilles tendon contracture (HP:0001771)1.81412080
125Thoracic kyphosis (HP:0002942)1.81130024
126Aortic dissection (HP:0002647)1.80574412
127Complement deficiency (HP:0004431)1.80424747
128Bowing of the arm (HP:0006488)1.80303235
129Bowed forearm bones (HP:0003956)1.80303235
130Hypertriglyceridemia (HP:0002155)1.80055669
131Supranuclear gaze palsy (HP:0000605)1.79513671
132Abnormal cartilage morphology (HP:0002763)1.77221020
133Lymphangioma (HP:0100764)1.77036991
134Restrictive lung disease (HP:0002091)1.76985403
135Abnormality of the thoracic spine (HP:0100711)1.76372282
136Chest pain (HP:0100749)1.76121339
137Inflammation of the large intestine (HP:0002037)1.75680946
138Pulmonary embolism (HP:0002204)1.75420641
139Osteomyelitis (HP:0002754)1.75254462
140Blue sclerae (HP:0000592)1.75027749
141Disproportionate tall stature (HP:0001519)1.74595512
142Increased connective tissue (HP:0009025)1.74533053
143Long toe (HP:0010511)1.74530753
144Abnormality of the 4th metacarpal (HP:0010012)1.73561183
145Hallux valgus (HP:0001822)1.73414693
146Abnormality of macrophages (HP:0004311)1.73037615
147Increased cerebral lipofuscin (HP:0011813)1.72625908
148Abnormal platelet volume (HP:0011876)1.71091813
149Abnormality of iron homeostasis (HP:0011031)1.70026177
150Osteolytic defects of the phalanges of the hand (HP:0009771)1.69825624
151Osteolytic defects of the hand bones (HP:0009699)1.69825624
152Mediastinal lymphadenopathy (HP:0100721)1.69411680
153Deviation of the hallux (HP:0010051)1.69408732
154Abnormality of complement system (HP:0005339)1.68716499
155Striae distensae (HP:0001065)1.68288231
156Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.67789577
157Spinal cord lesions (HP:0100561)1.67228173
158Syringomyelia (HP:0003396)1.67228173
159Mesangial abnormality (HP:0001966)1.66753153
160Increased mean platelet volume (HP:0011877)1.66533985
161Mitral stenosis (HP:0001718)1.65498077
162Cortical dysplasia (HP:0002539)1.65138792
163Tetraparesis (HP:0002273)1.64909168
164Biconcave vertebral bodies (HP:0004586)1.64442430
165Camptodactyly of toe (HP:0001836)1.63589113
166Bowel diverticulosis (HP:0005222)1.63373099
167Renal duplication (HP:0000075)1.63342938
168Viral hepatitis (HP:0006562)1.59555386

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.41134946
2PKN24.02815726
3MAP3K103.90807948
4ERN13.25870524
5PRPF4B3.17402600
6EEF2K3.09935624
7IRAK32.93565129
8RIPK42.74211865
9MAP4K12.66174814
10FGFR42.60169869
11TBK12.27754795
12TYK22.20054847
13SMG12.15708340
14IRAK42.15260356
15TTN2.02134548
16LRRK21.91375231
17PTK61.87560694
18BLK1.83463655
19TAOK21.73695967
20JAK31.73541997
21MAP3K131.58590186
22STK101.52703812
23RPS6KA41.52474498
24SCYL21.52342642
25SIK11.49854527
26ZAP701.41630806
27MAP2K31.40297088
28PDGFRA1.37140443
29FLT31.36518030
30TNK21.32675593
31RIPK11.32053562
32TESK21.31130448
33NME21.30883035
34KIT1.30243740
35MAP3K11.29473062
36PAK41.27218874
37CDC42BPA1.26834396
38IKBKE1.26648752
39TGFBR11.24033912
40NEK21.23222640
41GRK61.22130871
42EPHB11.20196070
43JAK11.18977512
44FGFR31.17409898
45SIK31.14095702
46FGR1.12599195
47KDR1.11960948
48BMX1.11419791
49TGFBR21.09375648
50IRAK21.09162841
51MARK21.07974012
52MAP3K111.07210605
53BCKDK1.04146233
54MAP3K81.02386153
55PASK1.02133400
56PRKD21.01422438
57TESK11.00956702
58FES1.00383333
59BTK0.96535598
60PDPK10.95647963
61CSF1R0.93189797
62EPHA20.86338174
63CDK40.85911697
64CDC70.83309869
65ALK0.82660780
66ILK0.81849032
67HCK0.81007663
68DYRK1B0.80622976
69TAOK10.79146451
70ITK0.79014900
71DDR20.78135445
72JAK20.76964859
73CSK0.76871586
74PDK10.76641149
75RPS6KB20.75680016
76MAP3K140.74621414
77CDK120.74535973
78ICK0.74172812
79MAP3K60.73655340
80CDK60.72926260
81PAK20.72573399
82IKBKB0.72422031
83MOS0.71519945
84SIK20.69947150
85MTOR0.69907550
86RPS6KC10.69222472
87RPS6KL10.69222472
88ARAF0.68528744
89CHUK0.66835432
90RPS6KA20.65870882
91MAP3K30.63721861
92SYK0.63457460
93PIM10.63301165
94PTK20.63259427
95GRK70.62476413
96STK40.62212433
97MARK30.61088628
98FGFR10.60682895
99IRAK10.57169179
100PIM20.56458284
101CAMKK10.56100171
102EPHA30.55500005
103MAPK110.54094505
104LCK0.53961608
105MAP2K20.53944346
106RET0.53219721
107MAPK120.52690207
108MAP2K60.51898748
109RPS6KA60.50918739
110PDGFRB0.48261046
111EPHB20.48227701
112NEK90.47529606
113KSR20.45464938
114PRKG20.45250438
115MAPK70.44754214
116NEK10.44198604
117MAP3K70.42932380
118DAPK30.41237645
119EGFR0.41218497
120TYRO30.39564968
121MAPKAPK30.39264493
122BUB10.37326242
123LYN0.34103179
124DYRK30.33102040
125RPS6KA10.32798573
126MAPKAPK20.29650589
127PAK10.29025019
128HIPK20.27968945
129MST1R0.27076343
130STK30.27042817
131MAP3K50.25414649
132CLK10.24814108
133MATK0.24573206

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.91509006
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.18587695
3Leishmaniasis_Homo sapiens_hsa051402.07822652
4Chronic myeloid leukemia_Homo sapiens_hsa052201.86378368
5Staphylococcus aureus infection_Homo sapiens_hsa051501.86065834
6Allograft rejection_Homo sapiens_hsa053301.82037652
7Antigen processing and presentation_Homo sapiens_hsa046121.76958077
8Osteoclast differentiation_Homo sapiens_hsa043801.65032189
9Measles_Homo sapiens_hsa051621.64103757
10B cell receptor signaling pathway_Homo sapiens_hsa046621.64060601
11Graft-versus-host disease_Homo sapiens_hsa053321.58419103
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.57339410
13Autoimmune thyroid disease_Homo sapiens_hsa053201.54719125
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.52120202
15Legionellosis_Homo sapiens_hsa051341.51477753
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51097429
17Sulfur relay system_Homo sapiens_hsa041221.49769082
18Viral myocarditis_Homo sapiens_hsa054161.47439526
19Caffeine metabolism_Homo sapiens_hsa002321.47411417
20Toxoplasmosis_Homo sapiens_hsa051451.45180523
21Apoptosis_Homo sapiens_hsa042101.43961474
22Shigellosis_Homo sapiens_hsa051311.40967429
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39029450
24Acute myeloid leukemia_Homo sapiens_hsa052211.38725906
25Primary immunodeficiency_Homo sapiens_hsa053401.37989194
26Herpes simplex infection_Homo sapiens_hsa051681.37226249
27One carbon pool by folate_Homo sapiens_hsa006701.36789207
28Small cell lung cancer_Homo sapiens_hsa052221.34013450
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32066776
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28718233
31Influenza A_Homo sapiens_hsa051641.25778182
32TNF signaling pathway_Homo sapiens_hsa046681.23454081
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22542419
34Hepatitis B_Homo sapiens_hsa051611.20890953
35Viral carcinogenesis_Homo sapiens_hsa052031.20819375
36African trypanosomiasis_Homo sapiens_hsa051431.19969452
37Asthma_Homo sapiens_hsa053101.15970148
38Notch signaling pathway_Homo sapiens_hsa043301.14984616
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.14841518
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13431046
41Pertussis_Homo sapiens_hsa051331.12813807
42Selenocompound metabolism_Homo sapiens_hsa004501.11847311
43Pancreatic cancer_Homo sapiens_hsa052121.11758744
44DNA replication_Homo sapiens_hsa030301.11142177
45Rheumatoid arthritis_Homo sapiens_hsa053231.10632213
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09130744
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.06907007
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06456803
49Bladder cancer_Homo sapiens_hsa052191.05986880
50Malaria_Homo sapiens_hsa051441.04875535
51Type I diabetes mellitus_Homo sapiens_hsa049401.04598347
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.02145725
53HTLV-I infection_Homo sapiens_hsa051661.01611807
54Complement and coagulation cascades_Homo sapiens_hsa046101.01423366
55Proteoglycans in cancer_Homo sapiens_hsa052051.01348674
56Ribosome_Homo sapiens_hsa030101.01161017
57Arginine biosynthesis_Homo sapiens_hsa002201.01055956
58Phagosome_Homo sapiens_hsa041450.99963707
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99928398
60Insulin resistance_Homo sapiens_hsa049310.97346993
61T cell receptor signaling pathway_Homo sapiens_hsa046600.95347737
62Tuberculosis_Homo sapiens_hsa051520.95102115
63Systemic lupus erythematosus_Homo sapiens_hsa053220.93969408
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.92974840
65Biosynthesis of amino acids_Homo sapiens_hsa012300.92904720
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91289933
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.90093798
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.90029514
69VEGF signaling pathway_Homo sapiens_hsa043700.90019645
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.87671359
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87038097
72Non-small cell lung cancer_Homo sapiens_hsa052230.85091134
73MicroRNAs in cancer_Homo sapiens_hsa052060.83874452
74Lysine degradation_Homo sapiens_hsa003100.83779826
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82798500
76Pentose phosphate pathway_Homo sapiens_hsa000300.81451795
77Amoebiasis_Homo sapiens_hsa051460.81430517
78HIF-1 signaling pathway_Homo sapiens_hsa040660.81161212
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80567552
80Focal adhesion_Homo sapiens_hsa045100.80432257
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.79643937
82Fructose and mannose metabolism_Homo sapiens_hsa000510.79179917
83Hepatitis C_Homo sapiens_hsa051600.78790655
84Renal cell carcinoma_Homo sapiens_hsa052110.78500823
85Salmonella infection_Homo sapiens_hsa051320.78313831
86Spliceosome_Homo sapiens_hsa030400.77784027
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76179956
88Epstein-Barr virus infection_Homo sapiens_hsa051690.75715710
89Lysosome_Homo sapiens_hsa041420.75541416
90Prolactin signaling pathway_Homo sapiens_hsa049170.75496992
91Carbon metabolism_Homo sapiens_hsa012000.74971805
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.74808462
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.74062773
94GnRH signaling pathway_Homo sapiens_hsa049120.73205453
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73003103
96Endocytosis_Homo sapiens_hsa041440.72328549
97Platelet activation_Homo sapiens_hsa046110.71901805
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.71676878
99Fatty acid degradation_Homo sapiens_hsa000710.71657870
100Endometrial cancer_Homo sapiens_hsa052130.71515406
101Colorectal cancer_Homo sapiens_hsa052100.69568038
102Galactose metabolism_Homo sapiens_hsa000520.69180561
103mTOR signaling pathway_Homo sapiens_hsa041500.68519449
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68294196
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66463593
106p53 signaling pathway_Homo sapiens_hsa041150.66306783
107Nitrogen metabolism_Homo sapiens_hsa009100.65865038
108Chemokine signaling pathway_Homo sapiens_hsa040620.64428225
109Base excision repair_Homo sapiens_hsa034100.62969061
110Thyroid cancer_Homo sapiens_hsa052160.62186207
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62043337
112PPAR signaling pathway_Homo sapiens_hsa033200.61007891
113ErbB signaling pathway_Homo sapiens_hsa040120.60543403
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60132834
115Insulin signaling pathway_Homo sapiens_hsa049100.60067368
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59251764
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59098041
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56819462
119Adherens junction_Homo sapiens_hsa045200.56385334
120Glioma_Homo sapiens_hsa052140.55567898
121Prion diseases_Homo sapiens_hsa050200.54335416
122Choline metabolism in cancer_Homo sapiens_hsa052310.54234290
123Hematopoietic cell lineage_Homo sapiens_hsa046400.53578481
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51868415
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51445106
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50878663
127Estrogen signaling pathway_Homo sapiens_hsa049150.47441954
128Type II diabetes mellitus_Homo sapiens_hsa049300.46644871
129FoxO signaling pathway_Homo sapiens_hsa040680.45163552
130MAPK signaling pathway_Homo sapiens_hsa040100.43412423
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.43179275
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42987148
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42509711

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