OGG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1N-acetylneuraminate metabolic process (GO:0006054)7.44023860
2response to misfolded protein (GO:0051788)7.01956559
3protoporphyrinogen IX biosynthetic process (GO:0006782)6.47789870
4positive regulation of histone deacetylation (GO:0031065)5.87464865
5regulation of MHC class II biosynthetic process (GO:0045346)5.37644728
6cellular extravasation (GO:0045123)5.33241518
7protoporphyrinogen IX metabolic process (GO:0046501)5.03491934
8positive regulation of protein deacetylation (GO:0090312)4.74712501
9chaperone-mediated protein transport (GO:0072321)4.73567219
10misfolded or incompletely synthesized protein catabolic process (GO:0006515)4.67912220
11centriole replication (GO:0007099)4.63719676
12amino sugar catabolic process (GO:0046348)4.46100121
13DNA strand elongation involved in DNA replication (GO:0006271)4.43757668
14telomere maintenance via semi-conservative replication (GO:0032201)4.20533335
15killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.18146440
16disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.18146440
17DNA strand elongation (GO:0022616)4.13274123
18DNA replication initiation (GO:0006270)4.08046508
19DNA unwinding involved in DNA replication (GO:0006268)3.99674714
20protein localization to kinetochore (GO:0034501)3.94899702
21regulation of histone deacetylation (GO:0031063)3.89886862
22intra-S DNA damage checkpoint (GO:0031573)3.79657036
23telomere maintenance via recombination (GO:0000722)3.73350611
24reactive oxygen species biosynthetic process (GO:1903409)3.67957906
25telomere maintenance via telomere lengthening (GO:0010833)3.66109230
26formation of translation preinitiation complex (GO:0001731)3.63510735
27N-acetylglucosamine metabolic process (GO:0006044)3.54084892
28ribosomal small subunit assembly (GO:0000028)3.52363983
29modulation of growth of symbiont involved in interaction with host (GO:0044144)3.49891491
30regulation of growth of symbiont in host (GO:0044126)3.49891491
31negative regulation of growth of symbiont in host (GO:0044130)3.49891491
32negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.49891491
33behavioral response to nicotine (GO:0035095)3.49870911
34nucleotide-excision repair, DNA gap filling (GO:0006297)3.43430566
35mitotic recombination (GO:0006312)3.37614215
36glycine metabolic process (GO:0006544)3.36360873
37opioid receptor signaling pathway (GO:0038003)3.35879625
38DNA replication checkpoint (GO:0000076)3.35686223
39protein localization to chromosome, centromeric region (GO:0071459)3.35037643
40folic acid-containing compound biosynthetic process (GO:0009396)3.34101483
41thalamus development (GO:0021794)3.33435020
42microglial cell activation (GO:0001774)3.33330452
43glyoxylate metabolic process (GO:0046487)3.33178999
44IMP biosynthetic process (GO:0006188)3.30434458
45negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.29048157
46insulin-like growth factor receptor signaling pathway (GO:0048009)3.25020048
47mitotic nuclear envelope disassembly (GO:0007077)3.23302439
48positive regulation of CREB transcription factor activity (GO:0032793)3.22979285
49DNA replication-dependent nucleosome assembly (GO:0006335)3.21745131
50DNA replication-dependent nucleosome organization (GO:0034723)3.21745131
51regulation of chemokine biosynthetic process (GO:0045073)3.20073314
52regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17755510
53DNA deamination (GO:0045006)3.08916603
54regulation of fatty acid transport (GO:2000191)3.07536409
55positive regulation of chemokine biosynthetic process (GO:0045080)3.07132903
56neutrophil mediated immunity (GO:0002446)3.06661259
57DNA duplex unwinding (GO:0032508)3.06580330
58DNA geometric change (GO:0032392)3.03211617
59mitotic metaphase plate congression (GO:0007080)3.02918296
60protein deneddylation (GO:0000338)3.02386953
61regulation of DNA endoreduplication (GO:0032875)3.01852249
62* base-excision repair (GO:0006284)3.00726274
63mitotic sister chromatid segregation (GO:0000070)2.98106828
64heterochromatin organization (GO:0070828)2.97659069
65positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.96247899
66modulation by virus of host process (GO:0019054)2.95898377
67maturation of SSU-rRNA (GO:0030490)2.95293643
68meiotic chromosome segregation (GO:0045132)2.94848582
69regulation of protein deacetylation (GO:0090311)2.94762499
70IMP metabolic process (GO:0046040)2.91810259
71ribosome biogenesis (GO:0042254)2.90449671
72serine family amino acid catabolic process (GO:0009071)2.90045661
73translational termination (GO:0006415)2.89763648
74viral transcription (GO:0019083)2.89426003
75nuclear envelope disassembly (GO:0051081)2.88809802
76membrane disassembly (GO:0030397)2.88809802
77mitotic G2 DNA damage checkpoint (GO:0007095)2.87192931
78heme biosynthetic process (GO:0006783)2.86825155
79* base-excision repair, AP site formation (GO:0006285)2.83927965
80regulation of synapse structural plasticity (GO:0051823)2.81496695
81DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.81263797
82mitotic G2/M transition checkpoint (GO:0044818)2.80917694
83cytokinetic process (GO:0032506)2.80271971
84GDP-mannose metabolic process (GO:0019673)2.79633810
85telomere maintenance (GO:0000723)2.77899182
86pseudouridine synthesis (GO:0001522)2.77675905
87telomere organization (GO:0032200)2.77374190
88nucleobase biosynthetic process (GO:0046112)2.76606964
89deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.76511977
90centriole assembly (GO:0098534)2.76457733
91intracellular estrogen receptor signaling pathway (GO:0030520)2.75835556
92establishment of chromosome localization (GO:0051303)2.74757734
93chromatin remodeling at centromere (GO:0031055)2.74550178
94translational elongation (GO:0006414)2.73620541
95negative regulation of histone acetylation (GO:0035067)2.71816679
96negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.70716345
97DNA damage response, signal transduction resulting in transcription (GO:0042772)2.70565979
98mitotic chromosome condensation (GO:0007076)2.70198613
99CENP-A containing nucleosome assembly (GO:0034080)2.68607012
100ribonucleoprotein complex biogenesis (GO:0022613)2.66767796
101metaphase plate congression (GO:0051310)2.66499816
102attachment of spindle microtubules to kinetochore (GO:0008608)2.66407511
103translational initiation (GO:0006413)2.66205827
104negative regulation of cAMP-mediated signaling (GO:0043951)2.65384256
105dosage compensation (GO:0007549)2.64087348
106negative regulation of phagocytosis (GO:0050765)2.64008727
107mitochondrial DNA replication (GO:0006264)2.63898122
108somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63057598
109somatic hypermutation of immunoglobulin genes (GO:0016446)2.63057598
110kinetochore organization (GO:0051383)2.62093118
111sequestering of actin monomers (GO:0042989)2.60862831
112telomere maintenance via telomerase (GO:0007004)2.60740501
113mitochondrial respiratory chain complex I assembly (GO:0032981)2.58618824
114NADH dehydrogenase complex assembly (GO:0010257)2.58618824
115mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58618824
116Arp2/3 complex-mediated actin nucleation (GO:0034314)2.58529770
117heme metabolic process (GO:0042168)2.58453607
118phosphatidylglycerol biosynthetic process (GO:0006655)2.57791811
119DNA conformation change (GO:0071103)2.56123969
120ribosomal small subunit biogenesis (GO:0042274)2.55344909
121sister chromatid segregation (GO:0000819)2.55316141
122mitotic DNA damage checkpoint (GO:0044773)2.53705204
123nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.52900594
124pyrimidine dimer repair (GO:0006290)2.51512938
125mitotic G1 DNA damage checkpoint (GO:0031571)2.51081280
126RNA-dependent DNA replication (GO:0006278)2.50185197
127synapsis (GO:0007129)2.50000847
128establishment of integrated proviral latency (GO:0075713)2.49175860
129mitochondrial DNA metabolic process (GO:0032042)2.49174065
130pyrimidine nucleotide catabolic process (GO:0006244)2.48601326
131regulation of sister chromatid cohesion (GO:0007063)2.48214290
132pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.47226637
133SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.47015572
134DNA replication-independent nucleosome organization (GO:0034724)2.46773930
135DNA replication-independent nucleosome assembly (GO:0006336)2.46773930
136protein localization to chromosome (GO:0034502)2.46117583
137negative regulation of RNA splicing (GO:0033119)2.45882235
138positive regulation of dendritic spine development (GO:0060999)2.45263537
139mitotic DNA integrity checkpoint (GO:0044774)2.45123354
140mismatch repair (GO:0006298)2.44618863
1413-UTR-mediated mRNA stabilization (GO:0070935)2.44549560
142response to oxygen radical (GO:0000305)2.44051624
143translesion synthesis (GO:0019985)2.43406235
144histone H3 deacetylation (GO:0070932)2.42395644
145chromatin assembly or disassembly (GO:0006333)2.42394943
146regulation of hydrogen peroxide metabolic process (GO:0010310)2.41363483
147oxidative demethylation (GO:0070989)2.39776641
148viral life cycle (GO:0019058)2.39103315
149myeloid leukocyte mediated immunity (GO:0002444)2.38415641
150G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.38261808
151antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.37790793
152antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.37790793
153folic acid metabolic process (GO:0046655)2.37553360
154negative regulation of macroautophagy (GO:0016242)2.37362006
155pyrimidine nucleobase catabolic process (GO:0006208)2.37267450
156maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.37192650
157regulation of gene silencing by RNA (GO:0060966)2.36984257
158regulation of posttranscriptional gene silencing (GO:0060147)2.36984257
159regulation of gene silencing by miRNA (GO:0060964)2.36984257
160mannosylation (GO:0097502)2.36266599
161sodium-independent organic anion transport (GO:0043252)2.36018217
162cotranslational protein targeting to membrane (GO:0006613)2.35875012
163protein targeting to ER (GO:0045047)2.35764038
164defense response to fungus (GO:0050832)2.35338275
165reciprocal meiotic recombination (GO:0007131)2.35246900
166reciprocal DNA recombination (GO:0035825)2.35246900
167transcription from mitochondrial promoter (GO:0006390)2.35094426
168ribosome assembly (GO:0042255)2.35073432
169nuclear pore organization (GO:0006999)2.35006295
170purine nucleobase biosynthetic process (GO:0009113)2.34960996
171negative regulation of interleukin-2 production (GO:0032703)2.34050749
172rRNA processing (GO:0006364)2.32540253
173ribosomal large subunit biogenesis (GO:0042273)2.32181561
174positive regulation of chromosome segregation (GO:0051984)2.31759505
175positive regulation of granulocyte differentiation (GO:0030854)2.31758712
176respiratory burst (GO:0045730)2.31568295
177microtubule nucleation (GO:0007020)2.29200144
178ncRNA 3-end processing (GO:0043628)2.29069105
179alkaloid metabolic process (GO:0009820)2.28779286
180regulation of gamma-delta T cell differentiation (GO:0045586)2.28556028
181histone H4 deacetylation (GO:0070933)2.28507604
182UV protection (GO:0009650)2.28455079
183negative regulation of cell cycle arrest (GO:0071157)2.27525038
184regulation of fatty acid beta-oxidation (GO:0031998)2.27225670
185ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.25574565
186L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.25548667
187negative regulation of mast cell activation (GO:0033004)2.25538411
188low-density lipoprotein particle remodeling (GO:0034374)2.25297879
189erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.24868460
190L-phenylalanine catabolic process (GO:0006559)2.24868460
191killing of cells of other organism (GO:0031640)2.23598237
192disruption of cells of other organism (GO:0044364)2.23598237

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.13386328
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.43527958
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.38335624
4EZH2_22144423_ChIP-Seq_EOC_Human3.35909066
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.33874959
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13584130
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90547812
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69061929
9CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.48900729
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.42076521
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.30811175
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29925352
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26865026
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26205486
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.24430199
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23851565
17MYC_22102868_ChIP-Seq_BL_Human2.14521517
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.13834192
19BCL6_27268052_Chip-Seq_Bcells_Human2.07850058
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03961286
21P68_20966046_ChIP-Seq_HELA_Human1.96080584
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94986937
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.92960175
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.91781255
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.91128265
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.89828438
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88437182
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87033936
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85593249
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.85495628
31VDR_21846776_ChIP-Seq_THP-1_Human1.84681101
32* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82989517
33XRN2_22483619_ChIP-Seq_HELA_Human1.81651120
34YY1_22570637_ChIP-Seq_MALME-3M_Human1.79770245
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79020271
36PHF8_20622854_ChIP-Seq_HELA_Human1.78267879
37EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.78119323
38FOXP3_21729870_ChIP-Seq_TREG_Human1.69713068
39* E2F1_20622854_ChIP-Seq_HELA_Human1.69336560
40IRF1_19129219_ChIP-ChIP_H3396_Human1.67336522
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.67159423
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.66856416
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.66264973
44VDR_23849224_ChIP-Seq_CD4+_Human1.64456165
45* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63289740
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62821184
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61661484
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61251030
49LXR_22292898_ChIP-Seq_THP-1_Human1.60488328
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58607587
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57716970
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56556627
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56172260
54BCOR_27268052_Chip-Seq_Bcells_Human1.55795452
55SA1_27219007_Chip-Seq_Bcells_Human1.55697217
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55450409
57AR_21909140_ChIP-Seq_LNCAP_Human1.54737084
58* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54428433
59DCP1A_22483619_ChIP-Seq_HELA_Human1.52667729
60DROSHA_22980978_ChIP-Seq_HELA_Human1.51882862
61CIITA_25753668_ChIP-Seq_RAJI_Human1.50413752
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48549361
63* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47728529
64* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40581327
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40262800
66* SMC4_20622854_ChIP-Seq_HELA_Human1.40161520
67GABP_19822575_ChIP-Seq_HepG2_Human1.40069975
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39809328
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39439087
70TTF2_22483619_ChIP-Seq_HELA_Human1.39140127
71IGF1R_20145208_ChIP-Seq_DFB_Human1.38956394
72CTCF_20526341_ChIP-Seq_ESCs_Human1.38812847
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.38737069
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38215354
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.38195058
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37990209
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36834520
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36610825
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36571493
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.36085425
81SPI1_23547873_ChIP-Seq_NB4_Human1.35477444
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35213461
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.34550799
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34031700
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33888076
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33284131
87TFEB_21752829_ChIP-Seq_HELA_Human1.33016379
88FOXP1_21924763_ChIP-Seq_HESCs_Human1.32892287
89* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31967853
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30945279
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29787471
92* ERA_21632823_ChIP-Seq_H3396_Human1.29550267
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29340837
94* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29168021
95MAF_26560356_Chip-Seq_TH1_Human1.28880353
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28756120
97ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26712723
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24525025
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23774867
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23141445
101IRF8_21731497_ChIP-ChIP_J774_Mouse1.22806735
102CTCF_21964334_Chip-Seq_Bcells_Human1.22684804
103TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.22199741
104UTX_26944678_Chip-Seq_JUKART_Human1.22016863
105YY1_21170310_ChIP-Seq_MESCs_Mouse1.21901385
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21829791
107P300_27268052_Chip-Seq_Bcells_Human1.20980602
108NOTCH1_21737748_ChIP-Seq_TLL_Human1.19532401
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19522443
110STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18583076
111CTCF_26484167_Chip-Seq_Bcells_Mouse1.18569830
112OCT4_19829295_ChIP-Seq_ESCs_Human1.18220666
113CTCF_27219007_Chip-Seq_Bcells_Human1.17678528
114RAC3_21632823_ChIP-Seq_H3396_Human1.17193549
115GATA1_19941827_ChIP-Seq_MEL_Mouse1.17102847
116KDM5A_27292631_Chip-Seq_BREAST_Human1.16593287
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16515061
118ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16273945
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14332891
120CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13091849
121MYB_26560356_Chip-Seq_TH2_Human1.12077595
122NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11912033
123SCL_19346495_ChIP-Seq_HPC-7_Human1.11862175
124MYB_26560356_Chip-Seq_TH1_Human1.11773732
125* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11699542
126* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10735685
127CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09988462
128FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09293567
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07750788
130RUNX1_22412390_ChIP-Seq_EML_Mouse1.07559176
131DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07414776
132EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07013337
133MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06860187
134* SRF_21415370_ChIP-Seq_HL-1_Mouse1.06818307
135KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06745208
136PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06655982
137* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06351107
138KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06163761
139VDR_24763502_ChIP-Seq_THP-1_Human1.05813651
140ELK1_19687146_ChIP-ChIP_HELA_Human1.03981238
141KDM2B_26808549_Chip-Seq_DND41_Human1.02602442
142YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01597614
143GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01556031
144* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01337415
145KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01192017
146E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01139253
147* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00979956
148BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00929174
149RARB_24833708_ChIP-Seq_LIVER_Mouse1.00576794
150EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99924691
151* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99113700
152NANOG_20526341_ChIP-Seq_ESCs_Human0.98916940
153OCT4_20526341_ChIP-Seq_ESCs_Human0.98544600
154KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94539527
155KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94539527
156KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94539527
157TCF7_22412390_ChIP-Seq_EML_Mouse0.93865564
158MAF_26560356_Chip-Seq_TH2_Human0.93740335
159STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92590633
160SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92530187
161GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91497767
162* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.89756875
163* ELK3_25401928_ChIP-Seq_HUVEC_Human0.89426687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract5.03153415
2MP0002396_abnormal_hematopoietic_system3.57643655
3MP0005365_abnormal_bile_salt3.44659404
4MP0003693_abnormal_embryo_hatching3.44388254
5MP0010094_abnormal_chromosome_stability3.39168885
6MP0001986_abnormal_taste_sensitivity3.18255934
7MP0003111_abnormal_nucleus_morphology3.13549780
8MP0003077_abnormal_cell_cycle3.13535397
9MP0004957_abnormal_blastocyst_morpholog3.08722628
10MP0005085_abnormal_gallbladder_physiolo2.84617202
11MP0002822_catalepsy2.84051090
12MP0008961_abnormal_basal_metabolism2.82185509
13MP0005360_urolithiasis2.80341172
14MP0004043_abnormal_pH_regulation2.72054449
15MP0003252_abnormal_bile_duct2.56896515
16MP0008007_abnormal_cellular_replicative2.54785577
17* MP0008058_abnormal_DNA_repair2.34243763
18MP0008057_abnormal_DNA_replication2.33400348
19MP0010352_gastrointestinal_tract_polyps2.09139593
20MP0003806_abnormal_nucleotide_metabolis2.02001159
21MP0003763_abnormal_thymus_physiology1.98188138
22MP0000490_abnormal_crypts_of1.96149559
23MP0008872_abnormal_physiological_respon1.84246666
24MP0000350_abnormal_cell_proliferation1.83459447
25MP0009333_abnormal_splenocyte_physiolog1.81833386
26MP0002735_abnormal_chemical_nociception1.78462247
27MP0001835_abnormal_antigen_presentation1.76766222
28MP0010329_abnormal_lipoprotein_level1.69747231
29MP0001968_abnormal_touch/_nociception1.68528888
30* MP0002019_abnormal_tumor_incidence1.66755493
31MP0002398_abnormal_bone_marrow1.66472647
32MP0005397_hematopoietic_system_phenotyp1.64140753
33MP0001545_abnormal_hematopoietic_system1.64140753
34MP0000858_altered_metastatic_potential1.61694288
35MP0009278_abnormal_bone_marrow1.60916573
36MP0005671_abnormal_response_to1.56571415
37MP0004808_abnormal_hematopoietic_stem1.55269715
38MP0010307_abnormal_tumor_latency1.52593542
39MP0001730_embryonic_growth_arrest1.52204086
40MP0003195_calcinosis1.51592194
41MP0003303_peritoneal_inflammation1.48414374
42MP0000689_abnormal_spleen_morphology1.46319307
43MP0002722_abnormal_immune_system1.44994374
44MP0001800_abnormal_humoral_immune1.44081885
45MP0009785_altered_susceptibility_to1.43304737
46MP0008932_abnormal_embryonic_tissue1.43271719
47MP0001764_abnormal_homeostasis1.43118654
48MP0002405_respiratory_system_inflammati1.42465673
49MP0000685_abnormal_immune_system1.41448763
50MP0005464_abnormal_platelet_physiology1.41018130
51MP0002452_abnormal_antigen_presenting1.36788755
52MP0000703_abnormal_thymus_morphology1.36597150
53MP0003436_decreased_susceptibility_to1.35407535
54MP0002420_abnormal_adaptive_immunity1.33916892
55MP0005023_abnormal_wound_healing1.32522311
56MP0001819_abnormal_immune_cell1.32448045
57MP0005423_abnormal_somatic_nervous1.32399768
58MP0003786_premature_aging1.31749291
59MP0008875_abnormal_xenobiotic_pharmacok1.31642610
60MP0004742_abnormal_vestibular_system1.29175616
61MP0002429_abnormal_blood_cell1.28433539
62MP0002249_abnormal_larynx_morphology1.28379978
63MP0005025_abnormal_response_to1.26650128
64MP0005380_embryogenesis_phenotype1.26605330
65MP0001672_abnormal_embryogenesis/_devel1.26605330
66MP0000716_abnormal_immune_system1.26422344
67MP0002723_abnormal_immune_serum1.25559511
68MP0002132_abnormal_respiratory_system1.25409466
69MP0010155_abnormal_intestine_physiology1.24738009
70MP0004142_abnormal_muscle_tone1.24716219
71MP0000313_abnormal_cell_death1.19755501
72MP0005076_abnormal_cell_differentiation1.19666627
73MP0005000_abnormal_immune_tolerance1.19378185
74MP0010234_abnormal_vibrissa_follicle1.18803024
75MP0004885_abnormal_endolymph1.17328158
76MP0003878_abnormal_ear_physiology1.16796079
77MP0005377_hearing/vestibular/ear_phenot1.16796079
78MP0000465_gastrointestinal_hemorrhage1.16200164
79MP0006054_spinal_hemorrhage1.15067931
80MP0005670_abnormal_white_adipose1.15062295
81MP0002970_abnormal_white_adipose1.14822993
82MP0002080_prenatal_lethality1.14317276
83MP0001853_heart_inflammation1.13646416
84MP0006035_abnormal_mitochondrial_morpho1.12206242
85MP0005645_abnormal_hypothalamus_physiol1.12136667
86MP0005075_abnormal_melanosome_morpholog1.10462959
87MP0001697_abnormal_embryo_size1.09663210
88MP0003984_embryonic_growth_retardation1.09586564
89MP0008995_early_reproductive_senescence1.08449444
90MP0002088_abnormal_embryonic_growth/wei1.07613794
91MP0003448_altered_tumor_morphology1.06521835
92MP0003718_maternal_effect1.04518014
93MP0008877_abnormal_DNA_methylation1.03932013
94MP0003724_increased_susceptibility_to1.02120446
95MP0006082_CNS_inflammation1.01933875
96MP0009115_abnormal_fat_cell1.00621776
97MP0005310_abnormal_salivary_gland0.99817624
98MP0002419_abnormal_innate_immunity0.99545070
99MP0005167_abnormal_blood-brain_barrier0.99539486
100MP0002085_abnormal_embryonic_tissue0.99500196
101MP0002210_abnormal_sex_determination0.99398948
102MP0001502_abnormal_circadian_rhythm0.98507004
103MP0002733_abnormal_thermal_nociception0.97968556
104MP0006292_abnormal_olfactory_placode0.96518963
105MP0005387_immune_system_phenotype0.96353922
106MP0001790_abnormal_immune_system0.96353922
107MP0003566_abnormal_cell_adhesion0.94364618
108MP0009764_decreased_sensitivity_to0.93735654
109MP0002736_abnormal_nociception_after0.93461922
110MP0000343_altered_response_to0.93282390
111MP0001145_abnormal_male_reproductive0.93073102
112MP0001905_abnormal_dopamine_level0.93053470
113MP0002086_abnormal_extraembryonic_tissu0.92423565
114MP0002933_joint_inflammation0.92304980
115MP0005266_abnormal_metabolism0.90810608
116MP0000477_abnormal_intestine_morphology0.90466335
117MP0004197_abnormal_fetal_growth/weight/0.89550387
118MP0000003_abnormal_adipose_tissue0.88892633
119MP0001845_abnormal_inflammatory_respons0.88748582
120MP0002067_abnormal_sensory_capabilities0.87100653
121MP0001915_intracranial_hemorrhage0.85865985
122MP0001873_stomach_inflammation0.85687675
123MP0002653_abnormal_ependyma_morphology0.85282762
124MP0004130_abnormal_muscle_cell0.84410623
125MP0005551_abnormal_eye_electrophysiolog0.84074736
126MP0005058_abnormal_lysosome_morphology0.83304812
127MP0005174_abnormal_tail_pigmentation0.81869766
128MP0009745_abnormal_behavioral_response0.80895418
129MP0001501_abnormal_sleep_pattern0.80873340
130MP0003567_abnormal_fetal_cardiomyocyte0.80611263
131MP0003635_abnormal_synaptic_transmissio0.80606180
132MP0002084_abnormal_developmental_patter0.80237196
133MP0002064_seizures0.80210376
134MP0009643_abnormal_urine_homeostasis0.79413736
135MP0002148_abnormal_hypersensitivity_rea0.79060183
136MP0002118_abnormal_lipid_homeostasis0.79031270
137MP0001970_abnormal_pain_threshold0.78907160
138MP0006036_abnormal_mitochondrial_physio0.78529909
139MP0000538_abnormal_urinary_bladder0.77675072
140MP0003186_abnormal_redox_activity0.76821316
141MP0001929_abnormal_gametogenesis0.76530815
142MP0010030_abnormal_orbit_morphology0.75633107
143MP0000653_abnormal_sex_gland0.75625301
144MP0003279_aneurysm0.74845390
145MP0003938_abnormal_ear_development0.74249962
146MP0002111_abnormal_tail_morphology0.73183056
147MP0001529_abnormal_vocalization0.72844555
148MP0003866_abnormal_defecation0.72505216
149MP0003123_paternal_imprinting0.72440103
150MP0003300_gastrointestinal_ulcer0.72022803
151MP0003698_abnormal_male_reproductive0.71355278
152MP0003705_abnormal_hypodermis_morpholog0.71002655
153MP0003191_abnormal_cellular_cholesterol0.69401160
154MP0005448_abnormal_energy_balance0.68432301
155MP0002557_abnormal_social/conspecific_i0.66853164
156MP0000015_abnormal_ear_pigmentation0.65169903
157MP0002089_abnormal_postnatal_growth/wei0.64940270
158MP0002272_abnormal_nervous_system0.64578219
159MP0004145_abnormal_muscle_electrophysio0.63261562
160MP0003119_abnormal_digestive_system0.62848892
161MP0001663_abnormal_digestive_system0.62771792

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.66933360
2IgM deficiency (HP:0002850)3.60522926
3Reticulocytopenia (HP:0001896)3.55901422
4Progressive microcephaly (HP:0000253)3.39880581
5Eczematoid dermatitis (HP:0000976)3.35227828
6Genetic anticipation (HP:0003743)3.21645868
7Hyperventilation (HP:0002883)3.18598379
811 pairs of ribs (HP:0000878)3.10826574
9Selective tooth agenesis (HP:0001592)3.09604052
10Retinal dysplasia (HP:0007973)2.98334932
11Chromsome breakage (HP:0040012)2.97394512
12Chromosomal breakage induced by crosslinking agents (HP:0003221)2.94640509
13Chronic obstructive pulmonary disease (HP:0006510)2.94569171
14Obstructive lung disease (HP:0006536)2.94569171
15Clumsiness (HP:0002312)2.84697465
16Thrombocytosis (HP:0001894)2.75912620
17Type I transferrin isoform profile (HP:0003642)2.74632515
18Abnormality of alanine metabolism (HP:0010916)2.73811374
19Hyperalaninemia (HP:0003348)2.73811374
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73811374
21Absent speech (HP:0001344)2.68453874
22Abnormality of the prostate (HP:0008775)2.67605439
23Nasal polyposis (HP:0100582)2.66076153
24Abnormality of the anterior horn cell (HP:0006802)2.64801137
25Degeneration of anterior horn cells (HP:0002398)2.64801137
26Petechiae (HP:0000967)2.58035805
27Recurrent abscess formation (HP:0002722)2.56178418
28Aplasia/Hypoplasia of the patella (HP:0006498)2.56043481
29Abnormal platelet volume (HP:0011876)2.52110142
30Cellulitis (HP:0100658)2.44841695
31Aplastic anemia (HP:0001915)2.43202186
32Missing ribs (HP:0000921)2.42902573
33Lissencephaly (HP:0001339)2.39224750
34Absent thumb (HP:0009777)2.38192653
35Reduced antithrombin III activity (HP:0001976)2.37251088
36Abnormality of the renal collecting system (HP:0004742)2.36163515
37Agnosia (HP:0010524)2.34996255
38Basal cell carcinoma (HP:0002671)2.30689994
39Recurrent bronchitis (HP:0002837)2.30339397
40Flat occiput (HP:0005469)2.30288203
41Myelodysplasia (HP:0002863)2.29518713
42Congenital stationary night blindness (HP:0007642)2.28908261
43Duplicated collecting system (HP:0000081)2.26787129
44Type II lissencephaly (HP:0007260)2.26668080
45Increased mean platelet volume (HP:0011877)2.24188917
46Metabolic alkalosis (HP:0200114)2.22652638
47Abnormality of cells of the erythroid lineage (HP:0012130)2.21849304
48Elevated erythrocyte sedimentation rate (HP:0003565)2.20105691
49Ureteral stenosis (HP:0000071)2.19520288
50Abnormality of the nasal mucosa (HP:0000433)2.19329473
51Abnormality of pyrimidine metabolism (HP:0004353)2.18725232
52Abnormality of chromosome stability (HP:0003220)2.18481190
53Meckel diverticulum (HP:0002245)2.18217050
54Rectal prolapse (HP:0002035)2.18113835
55Opisthotonus (HP:0002179)2.17725836
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.16353242
57Protruding tongue (HP:0010808)2.15214618
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15015894
59Bone marrow hypocellularity (HP:0005528)2.14974822
60Abnormality of the ileum (HP:0001549)2.14714574
61Ependymoma (HP:0002888)2.14527508
62Panhypogammaglobulinemia (HP:0003139)2.14130570
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.13450937
64Increased nuchal translucency (HP:0010880)2.13412269
65Hyperglycinemia (HP:0002154)2.13317641
66Abnormal number of erythroid precursors (HP:0012131)2.12486505
67Chest pain (HP:0100749)2.12223699
68Myositis (HP:0100614)2.12178104
69Cleft eyelid (HP:0000625)2.11119871
70Short thumb (HP:0009778)2.10871843
71Frequent falls (HP:0002359)2.10231941
72Broad-based gait (HP:0002136)2.09613236
73Increased neuronal autofluorescent lipopigment (HP:0002074)2.07370118
74Progressive cerebellar ataxia (HP:0002073)2.07312227
75Increased density of long bones (HP:0006392)2.06855491
76Renal Fanconi syndrome (HP:0001994)2.06386304
77IgG deficiency (HP:0004315)2.06075843
78Oral leukoplakia (HP:0002745)2.04948223
79Prolonged bleeding time (HP:0003010)2.04629482
80Recurrent fungal infections (HP:0002841)2.04118028
81Recurrent bacterial skin infections (HP:0005406)2.03453467
82Abnormal albumin level (HP:0012116)2.01583505
83Hypoalbuminemia (HP:0003073)2.01583505
84Increased hepatocellular lipid droplets (HP:0006565)2.01541265
85Nonimmune hydrops fetalis (HP:0001790)2.01334667
86Mitochondrial inheritance (HP:0001427)1.99993296
87Abnormal protein N-linked glycosylation (HP:0012347)1.99949681
88Abnormal protein glycosylation (HP:0012346)1.99949681
89Abnormal glycosylation (HP:0012345)1.99949681
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99949681
91Alkalosis (HP:0001948)1.99316365
92Recurrent gram-negative bacterial infections (HP:0005420)1.98611246
93Cutaneous photosensitivity (HP:0000992)1.97622647
94Exertional dyspnea (HP:0002875)1.97232234
95Hypoplasia of the pons (HP:0012110)1.96935923
96Pallor (HP:0000980)1.95757538
97Increased CSF lactate (HP:0002490)1.94658007
98Colon cancer (HP:0003003)1.94616187
99IgA deficiency (HP:0002720)1.94133036
100Increased intramyocellular lipid droplets (HP:0012240)1.92684695
101Abnormality of T cells (HP:0002843)1.92607914
102Rhabdomyolysis (HP:0003201)1.92514637
103Abnormality of T cell physiology (HP:0011840)1.92483464
104Lipid accumulation in hepatocytes (HP:0006561)1.92404783
105Asplenia (HP:0001746)1.92291397
106Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.92008530
107Multiple enchondromatosis (HP:0005701)1.91975866
108Bicuspid aortic valve (HP:0001647)1.91910004
109Inability to walk (HP:0002540)1.90066368
110Partial agenesis of the corpus callosum (HP:0001338)1.89041402
111Osteomyelitis (HP:0002754)1.88921664
112Amaurosis fugax (HP:0100576)1.88788682
113Aplasia/Hypoplasia of the uvula (HP:0010293)1.88525417
114Abnormal lung lobation (HP:0002101)1.87634554
115Supernumerary spleens (HP:0009799)1.87376623
116Broad distal phalanx of finger (HP:0009836)1.87185976
117Ectopic kidney (HP:0000086)1.86815675
118Slender long bone (HP:0003100)1.86663394
119Brushfield spots (HP:0001088)1.86449355
120Patellar aplasia (HP:0006443)1.85928255
121Increased muscle lipid content (HP:0009058)1.85669388
122Cutaneous melanoma (HP:0012056)1.85657536
123Acute encephalopathy (HP:0006846)1.85296228
124Respiratory difficulties (HP:0002880)1.85087468
125Squamous cell carcinoma (HP:0002860)1.84229754
126Combined immunodeficiency (HP:0005387)1.83545199
127Ureteral obstruction (HP:0006000)1.83157932
128Meningitis (HP:0001287)1.82231353
129Sloping forehead (HP:0000340)1.81893484
130Pachygyria (HP:0001302)1.81219619
131Breast hypoplasia (HP:0003187)1.81173242
132Abnormality of DNA repair (HP:0003254)1.81097781
133Lymphoma (HP:0002665)1.81019656
134Broad face (HP:0000283)1.80680382
135Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80661779
136Short 4th metacarpal (HP:0010044)1.80661779
137Absent radius (HP:0003974)1.79427012
138Pendular nystagmus (HP:0012043)1.79405704
139Carpal bone hypoplasia (HP:0001498)1.79385658
140Abnormal number of incisors (HP:0011064)1.79235428
141Impulsivity (HP:0100710)1.78174347
142Delayed CNS myelination (HP:0002188)1.77972540
143Mesangial abnormality (HP:0001966)1.77851252
144Duodenal stenosis (HP:0100867)1.76269510
145Small intestinal stenosis (HP:0012848)1.76269510
146Severe global developmental delay (HP:0011344)1.76244656
147Hemoptysis (HP:0002105)1.75802828
148Medulloblastoma (HP:0002885)1.75616315
149Gastrointestinal infarctions (HP:0005244)1.75226505
150Aplasia/Hypoplasia of the spleen (HP:0010451)1.74842624
151Impaired platelet aggregation (HP:0003540)1.74809777
152Abnormal platelet function (HP:0011869)1.74809777
153Tracheoesophageal fistula (HP:0002575)1.74475082
154Intellectual disability, severe (HP:0010864)1.74024376
155Abnormality of male internal genitalia (HP:0000022)1.73998146
156Recurrent viral infections (HP:0004429)1.73538375
157Abnormality of the preputium (HP:0100587)1.73060222
158Cerebral palsy (HP:0100021)1.72676915
159Diplopia (HP:0000651)1.72225896
160Abnormality of binocular vision (HP:0011514)1.72225896
161Supernumerary bones of the axial skeleton (HP:0009144)1.71900022
162Abnormality of the calcaneus (HP:0008364)1.71718977
163Microretrognathia (HP:0000308)1.71373183
164Trismus (HP:0000211)1.70111716
165T lymphocytopenia (HP:0005403)1.68876189
166Premature graying of hair (HP:0002216)1.68712923
167Anorexia (HP:0002039)1.68429623
168Abnormality of the pons (HP:0007361)1.68209617
169Hypochromic anemia (HP:0001931)1.67285130
170Fair hair (HP:0002286)1.66896776
171Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66755509
172Hypoplasia of the brainstem (HP:0002365)1.66695867
173Aplasia/Hypoplasia of the brainstem (HP:0007362)1.66695867
174Clubbing of toes (HP:0100760)1.66351591
175Hypokalemic alkalosis (HP:0001949)1.65089496
176Hypoplasia of the radius (HP:0002984)1.63936049
177Increased cerebral lipofuscin (HP:0011813)1.63563020
178Small hand (HP:0200055)1.63517599
179Abnormal biliary tract physiology (HP:0012439)1.63041465
180Bile duct proliferation (HP:0001408)1.63041465
181Long foot (HP:0001833)1.62821482

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D3.85196726
2CAMKK23.74814870
3TESK23.65509981
4VRK23.42225600
5BUB13.30077234
6CDC73.11872070
7CAMK1G2.65292113
8MAP4K12.63925841
9WEE12.62232091
10TNK22.57639892
11EEF2K2.51713756
12SMG12.38845021
13NUAK12.36167798
14CAMKK12.35626586
15SIK22.27497336
16NEK22.09365008
17STK102.07665196
18TLK11.96434775
19FLT31.82782476
20EIF2AK11.82703122
21BLK1.79438052
22ZAP701.79079123
23TTK1.77053565
24INSRR1.76142671
25TESK11.76079862
26NME21.68945355
27RPS6KB21.68587454
28MAP3K101.66544292
29KIT1.64362168
30EIF2AK31.63376290
31CLK11.61710367
32PASK1.54602601
33CDK71.54032419
34PAK41.52630429
35TAF11.49296900
36TXK1.45017355
37BTK1.44115819
38RPS6KA41.39247528
39VRK11.30862772
40LRRK21.30709559
41PIM21.29620031
42NEK11.26172009
43CAMK11.23268689
44ACVR1B1.19898907
45CDK191.19695566
46ADRBK21.18686346
47STK161.18667280
48ATR1.18186085
49MAP3K111.17133169
50MAP3K81.16940338
51PLK11.16732092
52CDK121.16181051
53KDR1.14941169
54SRPK11.13585729
55MARK21.13222088
56ERN11.12154697
57WNK41.11341992
58TSSK61.10941828
59DYRK21.09063631
60RIPK41.08999159
61CSF1R1.08743440
62CDK81.08053871
63AURKB1.07960292
64TYK21.07719242
65PIM11.07028543
66STK41.05381536
67DYRK31.01361382
68TGFBR11.01094300
69EPHA20.99632893
70IRAK40.99341682
71MATK0.99171866
72PKN20.99029397
73TEC0.97897677
74TRIB30.97519487
75CDK40.89214449
76MAP3K70.88246280
77GRK60.87749478
78TRPM70.86915422
79MAPKAPK30.82462834
80ILK0.80481331
81MARK10.79015673
82AURKA0.78727495
83RPS6KA60.78557989
84CHUK0.78009973
85SIK30.76984072
86STK240.76861081
87ICK0.76191422
88MELK0.75687170
89BCKDK0.75620069
90MAP2K20.75315446
91TBK10.75088365
92PLK40.73344497
93BMPR1B0.73206126
94STK30.73190052
95JAK30.72076237
96RPS6KL10.71797023
97RPS6KC10.71797023
98TAOK10.71750969
99CHEK20.71648691
100SCYL20.71328692
101FES0.71289439
102CAMK40.70127018
103LYN0.69426277
104CHEK10.69115154
105SYK0.68499519
106MAP3K140.67632264
107STK38L0.65309102
108PAK10.64998903
109ATM0.64959875
110FRK0.64383963
111SIK10.64278699
112MAPK130.63375734
113CSNK1G30.62653965
114GRK10.61860080
115LCK0.61691743
116CSNK1A1L0.60550530
117PRKD20.60540161
118IKBKE0.60006701
119LIMK10.59886002
120MAP2K30.59194669
121CDC42BPA0.57409860
122CASK0.57346121
123RPS6KA50.57115180
124CSK0.56636060
125IKBKB0.55912213
126ZAK0.55908713
127TYRO30.54937469
128PAK20.52349907
129CDK20.50004450
130CSNK2A20.49440136
131ADRBK10.48317128
132HCK0.47989312
133MAPK120.47550921
134CSNK1G10.46376509
135CSNK2A10.46064959
136MKNK10.45370346
137TAOK30.45334333
138MAPK40.43847116
139MAPK110.43518719
140DAPK10.43309854
141CCNB10.40610081
142NLK0.40216183
143TTN0.40183455
144CDK60.39483478
145BRSK20.36915980
146GRK50.33785927
147WNK30.32726863
148CSNK1G20.29753225
149STK110.29249532
150FGR0.28479007
151PDPK10.27245717
152PRKCZ0.24806587
153PRKCG0.24757679
154ABL20.23636454
155MAP2K40.22970049

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.69833819
2Mismatch repair_Homo sapiens_hsa034303.79343219
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.32296853
4* Base excision repair_Homo sapiens_hsa034103.12222292
5Homologous recombination_Homo sapiens_hsa034403.03399526
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.78053448
7One carbon pool by folate_Homo sapiens_hsa006702.58741442
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50518516
9Ribosome_Homo sapiens_hsa030102.45457806
10Nucleotide excision repair_Homo sapiens_hsa034202.39412370
11Non-homologous end-joining_Homo sapiens_hsa034502.37777249
12Spliceosome_Homo sapiens_hsa030402.34472780
13Cell cycle_Homo sapiens_hsa041102.17347721
14RNA transport_Homo sapiens_hsa030132.16300053
15Pyrimidine metabolism_Homo sapiens_hsa002402.01688953
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00736157
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97975146
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91486005
19RNA polymerase_Homo sapiens_hsa030201.80299748
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75342834
21Lysine degradation_Homo sapiens_hsa003101.74643031
22Proteasome_Homo sapiens_hsa030501.73533426
23Fanconi anemia pathway_Homo sapiens_hsa034601.72583845
24Oxidative phosphorylation_Homo sapiens_hsa001901.60082943
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.57676383
26p53 signaling pathway_Homo sapiens_hsa041151.49250318
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48729587
28RNA degradation_Homo sapiens_hsa030181.45451843
29Primary immunodeficiency_Homo sapiens_hsa053401.45430186
30Asthma_Homo sapiens_hsa053101.40532470
31Antigen processing and presentation_Homo sapiens_hsa046121.38137200
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35675809
33Parkinsons disease_Homo sapiens_hsa050121.32889302
34Basal transcription factors_Homo sapiens_hsa030221.31588884
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.20410149
36Systemic lupus erythematosus_Homo sapiens_hsa053221.16491765
37Renin-angiotensin system_Homo sapiens_hsa046141.16017168
38Staphylococcus aureus infection_Homo sapiens_hsa051501.15869307
39mRNA surveillance pathway_Homo sapiens_hsa030151.15662188
40Pentose phosphate pathway_Homo sapiens_hsa000301.13896245
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13825312
42Sulfur relay system_Homo sapiens_hsa041221.12414088
43Herpes simplex infection_Homo sapiens_hsa051681.10750433
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08842541
45Viral carcinogenesis_Homo sapiens_hsa052031.08344887
46Peroxisome_Homo sapiens_hsa041461.07561376
47Leishmaniasis_Homo sapiens_hsa051401.05827393
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05593388
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.05142959
50Epstein-Barr virus infection_Homo sapiens_hsa051691.03626558
51B cell receptor signaling pathway_Homo sapiens_hsa046621.01779668
52Glycerolipid metabolism_Homo sapiens_hsa005611.01536547
53Measles_Homo sapiens_hsa051621.00951644
54Regulation of autophagy_Homo sapiens_hsa041400.99886935
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99883182
56Linoleic acid metabolism_Homo sapiens_hsa005910.96642999
57Biosynthesis of amino acids_Homo sapiens_hsa012300.94369601
58Nicotine addiction_Homo sapiens_hsa050330.94278838
59Tryptophan metabolism_Homo sapiens_hsa003800.93035618
60Morphine addiction_Homo sapiens_hsa050320.90780700
61Acute myeloid leukemia_Homo sapiens_hsa052210.90511883
62Legionellosis_Homo sapiens_hsa051340.90505687
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.88032621
64Purine metabolism_Homo sapiens_hsa002300.87551700
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.86635567
66HTLV-I infection_Homo sapiens_hsa051660.86482999
67Apoptosis_Homo sapiens_hsa042100.86359539
68Phototransduction_Homo sapiens_hsa047440.86245110
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83780671
70Folate biosynthesis_Homo sapiens_hsa007900.83566553
71Other glycan degradation_Homo sapiens_hsa005110.81164015
72Small cell lung cancer_Homo sapiens_hsa052220.81082046
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80589336
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79602435
75Chronic myeloid leukemia_Homo sapiens_hsa052200.79205071
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78812388
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78323601
78Histidine metabolism_Homo sapiens_hsa003400.77772708
79Hematopoietic cell lineage_Homo sapiens_hsa046400.77546972
80Huntingtons disease_Homo sapiens_hsa050160.77425625
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76938433
82Selenocompound metabolism_Homo sapiens_hsa004500.76437586
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75903454
84Taste transduction_Homo sapiens_hsa047420.75421229
85Thyroid cancer_Homo sapiens_hsa052160.74106651
86Pyruvate metabolism_Homo sapiens_hsa006200.71403339
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71005616
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70564735
89Glutathione metabolism_Homo sapiens_hsa004800.70190824
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.69310216
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.66009184
92Hepatitis B_Homo sapiens_hsa051610.65921122
93Viral myocarditis_Homo sapiens_hsa054160.65451115
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64924021
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64480833
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63637299
97Shigellosis_Homo sapiens_hsa051310.63510365
98Osteoclast differentiation_Homo sapiens_hsa043800.61356657
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.61330341
100Metabolic pathways_Homo sapiens_hsa011000.60753803
101MicroRNAs in cancer_Homo sapiens_hsa052060.59661870
102Colorectal cancer_Homo sapiens_hsa052100.59522857
103Graft-versus-host disease_Homo sapiens_hsa053320.58824615
104Galactose metabolism_Homo sapiens_hsa000520.58430623
105Retinol metabolism_Homo sapiens_hsa008300.57630832
106Autoimmune thyroid disease_Homo sapiens_hsa053200.57132316
107Caffeine metabolism_Homo sapiens_hsa002320.56849753
108Vitamin B6 metabolism_Homo sapiens_hsa007500.55495772
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55263356
110T cell receptor signaling pathway_Homo sapiens_hsa046600.55031148
111Allograft rejection_Homo sapiens_hsa053300.54305815
112Sulfur metabolism_Homo sapiens_hsa009200.54113790
113Carbon metabolism_Homo sapiens_hsa012000.53753527
114Influenza A_Homo sapiens_hsa051640.53480664
115Fat digestion and absorption_Homo sapiens_hsa049750.53161664
116Glutamatergic synapse_Homo sapiens_hsa047240.50909200
117Butanoate metabolism_Homo sapiens_hsa006500.50580917
118Phenylalanine metabolism_Homo sapiens_hsa003600.50024231
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.49980492
120Notch signaling pathway_Homo sapiens_hsa043300.49884526
121N-Glycan biosynthesis_Homo sapiens_hsa005100.49278298
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48841792
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48535232
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.48381629
125Bladder cancer_Homo sapiens_hsa052190.48343722
126Chemical carcinogenesis_Homo sapiens_hsa052040.48202725
127Complement and coagulation cascades_Homo sapiens_hsa046100.47898398
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47206585
129ABC transporters_Homo sapiens_hsa020100.45857374
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45318480
131Fructose and mannose metabolism_Homo sapiens_hsa000510.45082061
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.44486888
133Alzheimers disease_Homo sapiens_hsa050100.44171101
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43892514
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43039351
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42489326
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42164632
138Pancreatic cancer_Homo sapiens_hsa052120.41969351
139Lysosome_Homo sapiens_hsa041420.40884921
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40829777
141Toxoplasmosis_Homo sapiens_hsa051450.40040721
142Cholinergic synapse_Homo sapiens_hsa047250.37669441
143HIF-1 signaling pathway_Homo sapiens_hsa040660.37259485
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36868993
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36181003
146Protein export_Homo sapiens_hsa030600.34088100
147TGF-beta signaling pathway_Homo sapiens_hsa043500.34000766
148Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32502880
149Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31244463
150Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30666101
151Vitamin digestion and absorption_Homo sapiens_hsa049770.30154827
152Platelet activation_Homo sapiens_hsa046110.29850172
153Pertussis_Homo sapiens_hsa051330.29679056
154Malaria_Homo sapiens_hsa051440.29033197
155Arachidonic acid metabolism_Homo sapiens_hsa005900.28826840
156Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28138123

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