OGN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)7.45871462
2collagen fibril organization (GO:0030199)6.70926935
3sequestering of extracellular ligand from receptor (GO:0035581)5.58651475
4peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.58170124
5muscle filament sliding (GO:0030049)5.34368239
6actin-myosin filament sliding (GO:0033275)5.34368239
7bone trabecula formation (GO:0060346)5.29580393
8chondrocyte proliferation (GO:0035988)5.23065761
9extracellular fibril organization (GO:0043206)4.82268218
10actin-mediated cell contraction (GO:0070252)4.69944719
11dermatan sulfate biosynthetic process (GO:0030208)4.59204246
12collagen metabolic process (GO:0032963)4.42063821
13endodermal cell differentiation (GO:0035987)4.39710409
14collagen catabolic process (GO:0030574)4.38791567
15metanephric mesenchyme development (GO:0072075)4.34503648
16myofibril assembly (GO:0030239)4.29881563
17skeletal muscle contraction (GO:0003009)4.25384311
18fibril organization (GO:0097435)4.21360098
19dermatan sulfate metabolic process (GO:0030205)4.20085986
20multicellular organismal macromolecule metabolic process (GO:0044259)4.19855230
21kidney mesenchyme development (GO:0072074)4.13200837
22multicellular organismal catabolic process (GO:0044243)4.07364722
23* keratan sulfate catabolic process (GO:0042340)4.02751131
24multicellular organismal metabolic process (GO:0044236)4.00959959
25glomerulus development (GO:0032835)3.94167856
26extracellular matrix assembly (GO:0085029)3.92734885
27regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.88011447
28positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.87029593
29regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.82173192
30blood vessel maturation (GO:0001955)3.80251328
31extracellular matrix disassembly (GO:0022617)3.79898438
32regulation of skeletal muscle contraction (GO:0014819)3.79384262
33skin morphogenesis (GO:0043589)3.79373346
34neuron projection extension involved in neuron projection guidance (GO:1902284)3.77677500
35axon extension involved in axon guidance (GO:0048846)3.77677500
36retina vasculature morphogenesis in camera-type eye (GO:0061299)3.70885134
37cell migration involved in heart development (GO:0060973)3.69080897
38glomerular basement membrane development (GO:0032836)3.68158627
39actin filament-based movement (GO:0030048)3.64625452
40basement membrane organization (GO:0071711)3.62268939
41lung vasculature development (GO:0060426)3.58205802
42respiratory tube development (GO:0030323)3.57103786
43plasma membrane repair (GO:0001778)3.54277694
44neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.50539923
45smooth muscle tissue development (GO:0048745)3.48525912
46regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.46986375
47sarcomere organization (GO:0045214)3.46970910
48extracellular regulation of signal transduction (GO:1900115)3.46825056
49extracellular negative regulation of signal transduction (GO:1900116)3.46825056
50regulation of cardiac muscle cell differentiation (GO:2000725)3.44035906
51insulin-like growth factor receptor signaling pathway (GO:0048009)3.43749218
52glomerular filtration (GO:0003094)3.38651965
53chondrocyte development (GO:0002063)3.36237016
54actomyosin structure organization (GO:0031032)3.35374828
55lymph vessel development (GO:0001945)3.33842677
56negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.33570720
57mesenchymal-epithelial cell signaling (GO:0060638)3.31214743
58endocrine hormone secretion (GO:0060986)3.27393000
59regulation of muscle hypertrophy (GO:0014743)3.25786633
60positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.22360688
61negative regulation of fatty acid transport (GO:2000192)3.21907829
62positive regulation of glomerulus development (GO:0090193)3.21593362
63response to parathyroid hormone (GO:0071107)3.20735835
64regulation of cardiac muscle hypertrophy (GO:0010611)3.19606345
65extracellular matrix organization (GO:0030198)3.19029883
66extracellular structure organization (GO:0043062)3.17733848
67epithelial cell-cell adhesion (GO:0090136)3.14099477
68mesenchymal cell differentiation involved in kidney development (GO:0072161)3.13299626
69mesenchymal cell differentiation involved in renal system development (GO:2001012)3.13299626
70vascular endothelial growth factor signaling pathway (GO:0038084)3.13222199
71positive regulation of mesenchymal cell proliferation (GO:0002053)3.12844680
72endothelial cell morphogenesis (GO:0001886)3.10038937
73cell adhesion mediated by integrin (GO:0033627)3.09446315
74renal filtration (GO:0097205)3.08720382
75protein localization to cell surface (GO:0034394)3.07928362
76regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.07872246
77negative regulation of chondrocyte differentiation (GO:0032331)3.06353697
78cell proliferation involved in metanephros development (GO:0072203)3.06044633
79regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.02952400
80negative regulation of catenin import into nucleus (GO:0035414)3.02078567
81regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.00981305
82embryonic cranial skeleton morphogenesis (GO:0048701)3.00421905
83G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.97709270
84regulation of mesenchymal cell proliferation (GO:0010464)2.97122788
85trabecula formation (GO:0060343)2.96243509
86planar cell polarity pathway involved in neural tube closure (GO:0090179)2.95875016
87sarcoplasmic reticulum calcium ion transport (GO:0070296)2.95346759
88artery development (GO:0060840)2.93541585
89lung lobe morphogenesis (GO:0060463)2.93222998
90regulation of SMAD protein import into nucleus (GO:0060390)2.92653661
91negative regulation of potassium ion transmembrane transport (GO:1901380)2.89441292
92cell differentiation involved in metanephros development (GO:0072202)2.88630964
93head development (GO:0060322)2.88135365
94hippo signaling (GO:0035329)2.87873419
95regulation of muscle adaptation (GO:0043502)2.87670644
96peptidyl-proline hydroxylation (GO:0019511)2.85973213
97positive regulation of myoblast differentiation (GO:0045663)2.85179148
98striated muscle contraction (GO:0006941)2.84231577
99middle ear morphogenesis (GO:0042474)2.83898278
100regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.83341734
101camera-type eye morphogenesis (GO:0048593)2.80707871
102cellular response to epinephrine stimulus (GO:0071872)2.80648756
103positive regulation of glycogen biosynthetic process (GO:0045725)2.80627714
104cardiac myofibril assembly (GO:0055003)2.79906471
105endocardial cushion development (GO:0003197)2.79781055
106regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.78798306
107craniofacial suture morphogenesis (GO:0097094)2.77626773
108regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.77625276
109apoptotic cell clearance (GO:0043277)2.76168891
110regulation of macrophage cytokine production (GO:0010935)2.74283318
111negative regulation of protein localization to cell surface (GO:2000009)2.73569024
112muscle organ development (GO:0007517)2.71882447
113skeletal muscle tissue development (GO:0007519)2.71646793
114negative regulation of cardiac muscle tissue growth (GO:0055022)2.71446842
115negative regulation of heart growth (GO:0061117)2.71446842
116positive regulation of Rho protein signal transduction (GO:0035025)2.70442404
117lymphangiogenesis (GO:0001946)2.69804851
118regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.69703780
119muscle structure development (GO:0061061)2.69217842
120face morphogenesis (GO:0060325)2.68512582
121blood vessel remodeling (GO:0001974)2.67350670
122protein hydroxylation (GO:0018126)2.67265558
123epoxygenase P450 pathway (GO:0019373)2.66076793
124positive regulation of epithelial to mesenchymal transition (GO:0010718)2.66036983
125response to inactivity (GO:0014854)2.65982553
126regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.65484059
127cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.64032566
128negative regulation of cartilage development (GO:0061037)2.63370370
129positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.63261498
130muscle tissue development (GO:0060537)2.62548398
131phagocytosis, recognition (GO:0006910)2.62495544
132myelination in peripheral nervous system (GO:0022011)2.62368042
133peripheral nervous system axon ensheathment (GO:0032292)2.62368042
134regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.61944013
135positive regulation of myotube differentiation (GO:0010831)2.61237160
136positive regulation of metanephros development (GO:0072216)2.60941956
137chondroitin sulfate catabolic process (GO:0030207)2.60924082
138cGMP-mediated signaling (GO:0019934)2.60657083
139regulation of metanephros development (GO:0072215)2.59678869
140regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.59415026
141protein trimerization (GO:0070206)2.59340024
142muscle contraction (GO:0006936)2.59252542
143regulation of sarcomere organization (GO:0060297)2.59175203
144vasculature development (GO:0001944)2.58742501
145negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.58611977
146cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.57897205
147wound healing, spreading of epidermal cells (GO:0035313)2.57354710
148outer ear morphogenesis (GO:0042473)2.57127089
149cardiac muscle cell development (GO:0055013)2.56484997
150substrate adhesion-dependent cell spreading (GO:0034446)2.55755911
151cell proliferation involved in kidney development (GO:0072111)2.55681903

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.15576131
2* RARG_19884340_ChIP-ChIP_MEFs_Mouse4.08301635
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.72996392
4CLOCK_20551151_ChIP-Seq_293T_Human3.24223090
5* ESR1_22446102_ChIP-Seq_UTERUS_Mouse3.14443666
6CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.81806486
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.77186834
8CJUN_26792858_Chip-Seq_BT549_Human2.74326049
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.71009986
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.57367641
11CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.37536952
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.33685583
13RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.33266889
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.26732995
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24405710
16NRF2_20460467_ChIP-Seq_MEFs_Mouse2.24342015
17NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.24342015
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.22361487
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.12265757
20BRD4_25478319_ChIP-Seq_HGPS_Human1.98103351
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.92881123
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92136794
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90832950
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88637439
25EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.85984876
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.77806627
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.76677487
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75677312
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74815561
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.74462932
31EZH2_22144423_ChIP-Seq_EOC_Human1.73412812
32* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72841548
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68247780
34* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67967023
35TP53_18474530_ChIP-ChIP_U2OS_Human1.66965295
36TP53_16413492_ChIP-PET_HCT116_Human1.60832454
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59178874
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59178874
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53174432
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.51842780
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.51694732
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51032761
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.50364097
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.50254973
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47333854
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.46506604
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.45668177
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45051676
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43162301
50TBX20_22328084_ChIP-Seq_HEART_Mouse1.41922810
51TBX20_22080862_ChIP-Seq_HEART_Mouse1.41922810
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41685934
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39831792
54SOX2_20726797_ChIP-Seq_SW620_Human1.39778647
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.39385069
56FUS_26573619_Chip-Seq_HEK293_Human1.37153449
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33308767
58TAF15_26573619_Chip-Seq_HEK293_Human1.33127338
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31212134
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.30861779
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30298102
62AR_21572438_ChIP-Seq_LNCaP_Human1.30223194
63SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30096973
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27969783
65SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26600992
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26600992
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26320591
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25664911
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25374401
70MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.24572579
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24422490
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24006012
73JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23515692
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22353285
75JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21528215
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21444581
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21117766
78GATA1_22025678_ChIP-Seq_K562_Human1.21005520
79SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19579398
80VDR_22108803_ChIP-Seq_LS180_Human1.18931462
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18796544
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.18761030
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.18530751
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16916002
85* TP53_20018659_ChIP-ChIP_R1E_Mouse1.16136985
86P300_19829295_ChIP-Seq_ESCs_Human1.14801832
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14601937
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14391149
89NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14363666
90KDM2B_26808549_Chip-Seq_REH_Human1.14144616
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13768534
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.13760447
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13462965
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13036287
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12939981
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12177432
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11909000
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11742178
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11453734
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.11292655
101JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10546276
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09665927
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.09587284
104SMAD3_21741376_ChIP-Seq_HESCs_Human1.08831399
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08486105
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08298745
107SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08002168
108EGR1_19374776_ChIP-ChIP_THP-1_Human1.07878319
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07822415
110UBF1/2_26484160_Chip-Seq_HMECs_Human1.07025535
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06688854
112BCAT_22108803_ChIP-Seq_LS180_Human1.05915268
113FOXO3_23340844_ChIP-Seq_DLD1_Human1.05617448
114P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05457887
115TCF4_18268006_ChIP-ChIP_LS174T_Human1.05141171
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04917769
117CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04731732
118GBX2_23144817_ChIP-Seq_PC3_Human1.02734752
119ISL1_27105846_Chip-Seq_CPCs_Mouse1.02704010
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01505718
121SA1_22415368_ChIP-Seq_MEFs_Mouse1.00189008
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00178900
123RXR_22108803_ChIP-Seq_LS180_Human0.98696927
124AHR_22903824_ChIP-Seq_MCF-7_Human0.97387898
125MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95938368
126WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94948600
127ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92396036
128JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92199212
129ELK3_25401928_ChIP-Seq_HUVEC_Human0.92186137
130PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91726120
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.91273527
132DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90462530
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90391294
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90315445
135RNF2_27304074_Chip-Seq_ESCs_Mouse0.88851447
136EZH2_27304074_Chip-Seq_ESCs_Mouse0.88597338
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86887777
138TP63_23658742_ChIP-Seq_EP156T_Human0.86539177
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86068669
140RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84875562

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0008438_abnormal_cutaneous_collagen8.77487222
2MP0005503_abnormal_tendon_morphology6.95700909
3* MP0005275_abnormal_skin_tensile6.01148414
4MP0001958_emphysema3.72656773
5MP0003705_abnormal_hypodermis_morpholog3.32569029
6MP0003279_aneurysm3.05076429
7MP0009384_cardiac_valve_regurgitation2.86776994
8MP0004272_abnormal_basement_membrane2.79218003
9MP0002108_abnormal_muscle_morphology2.42789271
10MP0005508_abnormal_skeleton_morphology2.25710510
11MP0006054_spinal_hemorrhage2.13189155
12MP0000751_myopathy1.84270994
13* MP0002060_abnormal_skin_morphology1.83323370
14MP0004036_abnormal_muscle_relaxation1.82644330
15MP0005670_abnormal_white_adipose1.82364806
16MP0003011_delayed_dark_adaptation1.80992953
17MP0002295_abnormal_pulmonary_circulatio1.79298181
18MP0003566_abnormal_cell_adhesion1.76515770
19MP0010368_abnormal_lymphatic_system1.70694634
20MP0005623_abnormal_meninges_morphology1.69066260
21MP0009250_abnormal_appendicular_skeleto1.68715543
22MP0005257_abnormal_intraocular_pressure1.67524470
23MP0001542_abnormal_bone_strength1.65509727
24MP0003385_abnormal_body_wall1.55066966
25MP0001879_abnormal_lymphatic_vessel1.50128775
26MP0000767_abnormal_smooth_muscle1.43099361
27MP0002106_abnormal_muscle_physiology1.42710506
28MP0002896_abnormal_bone_mineralization1.40597495
29MP0005023_abnormal_wound_healing1.39663671
30MP0004215_abnormal_myocardial_fiber1.39341378
31MP0000534_abnormal_ureter_morphology1.37413475
32MP0002282_abnormal_trachea_morphology1.35775676
33MP0000013_abnormal_adipose_tissue1.35765426
34MP0003115_abnormal_respiratory_system1.30691178
35MP0000733_abnormal_muscle_development1.27785519
36MP0005171_absent_coat_pigmentation1.27213374
37MP0003122_maternal_imprinting1.26252571
38MP0001243_abnormal_dermal_layer1.26184911
39MP0004134_abnormal_chest_morphology1.25497891
40MP0003283_abnormal_digestive_organ1.24774527
41MP0002837_dystrophic_cardiac_calcinosis1.24365020
42MP0003091_abnormal_cell_migration1.22628800
43MP0005390_skeleton_phenotype1.20860532
44MP0010030_abnormal_orbit_morphology1.20806858
45MP0001299_abnormal_eye_distance/1.20597816
46MP0000749_muscle_degeneration1.19996015
47MP0003942_abnormal_urinary_system1.18155467
48MP0002933_joint_inflammation1.16481634
49MP0000163_abnormal_cartilage_morphology1.15977998
50MP0002115_abnormal_skeleton_extremities1.12619821
51MP0003941_abnormal_skin_development1.11051385
52MP0002168_other_aberrant_phenotype1.07062242
53MP0009780_abnormal_chondrocyte_physiolo1.05098601
54MP0008004_abnormal_stomach_pH1.04574881
55MP0000003_abnormal_adipose_tissue1.00637302
56MP0002269_muscular_atrophy0.99687406
57MP0000428_abnormal_craniofacial_morphol0.98030275
58MP0005388_respiratory_system_phenotype0.97036327
59MP0002133_abnormal_respiratory_system0.97036327
60MP0006138_congestive_heart_failure0.96032768
61MP0003045_fibrosis0.94249334
62MP0004084_abnormal_cardiac_muscle0.93112501
63MP0000462_abnormal_digestive_system0.93014215
64MP0004130_abnormal_muscle_cell0.92642822
65MP0005369_muscle_phenotype0.92418507
66MP0002972_abnormal_cardiac_muscle0.92223752
67MP0002113_abnormal_skeleton_development0.92098848
68MP0001661_extended_life_span0.91470135
69MP0002932_abnormal_joint_morphology0.91182649
70MP0002127_abnormal_cardiovascular_syste0.91104993
71MP0002249_abnormal_larynx_morphology0.90592119
72MP0005375_adipose_tissue_phenotype0.90362219
73MP0002998_abnormal_bone_remodeling0.90300281
74MP0005595_abnormal_vascular_smooth0.90101652
75MP0003935_abnormal_craniofacial_develop0.87486185
76MP0003828_pulmonary_edema0.87409488
77MP0002971_abnormal_brown_adipose0.86467287
78MP0009053_abnormal_anal_canal0.86175114
79MP0002128_abnormal_blood_circulation0.85980112
80MP0004145_abnormal_muscle_electrophysio0.84655363
81MP0004087_abnormal_muscle_fiber0.84494186
82MP0000750_abnormal_muscle_regeneration0.83921694
83MP0000049_abnormal_middle_ear0.82221718
84MP0002114_abnormal_axial_skeleton0.81748548
85MP0001175_abnormal_lung_morphology0.80647574
86MP0000537_abnormal_urethra_morphology0.80010813
87MP0003755_abnormal_palate_morphology0.79893029
88MP0004883_abnormal_blood_vessel0.79175623
89MP0005330_cardiomyopathy0.78370389
90MP0001614_abnormal_blood_vessel0.75779702
91MP0000432_abnormal_head_morphology0.75584418
92MP0010352_gastrointestinal_tract_polyps0.75529859
93MP0004484_altered_response_of0.75070465
94MP0002009_preneoplasia0.74209100
95MP0002109_abnormal_limb_morphology0.74025342
96MP0000762_abnormal_tongue_morphology0.73135265
97MP0005164_abnormal_response_to0.73099546
98MP0003950_abnormal_plasma_membrane0.72360338
99MP0000516_abnormal_urinary_system0.72222068
100MP0005367_renal/urinary_system_phenotyp0.72222068
101MP0000759_abnormal_skeletal_muscle0.71700570
102MP0000343_altered_response_to0.71037856
103MP0001177_atelectasis0.70749757
104MP0001533_abnormal_skeleton_physiology0.70142190
105MP0003795_abnormal_bone_structure0.69679992
106MP0005620_abnormal_muscle_contractility0.69217232
107MP0001544_abnormal_cardiovascular_syste0.68696291
108MP0005385_cardiovascular_system_phenoty0.68696291
109MP0003300_gastrointestinal_ulcer0.68612977
110MP0002116_abnormal_craniofacial_bone0.68535962
111MP0010386_abnormal_urinary_bladder0.68332054
112MP0002233_abnormal_nose_morphology0.67505615
113MP0000266_abnormal_heart_morphology0.67453419
114MP0002089_abnormal_postnatal_growth/wei0.67221978
115MP0002925_abnormal_cardiovascular_devel0.65905068
116MP0005666_abnormal_adipose_tissue0.65764521
117MP0010630_abnormal_cardiac_muscle0.65733632
118MP0000747_muscle_weakness0.65296609
119MP0003937_abnormal_limbs/digits/tail_de0.63613271
120MP0009115_abnormal_fat_cell0.62258226
121MP0004085_abnormal_heartbeat0.60342170

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.32618827
2Distal arthrogryposis (HP:0005684)7.89705667
3Premature rupture of membranes (HP:0001788)6.98712526
4Ankle contracture (HP:0006466)5.63521969
5Broad metatarsal (HP:0001783)5.56180890
6Aortic dissection (HP:0002647)5.30595477
7Calcaneovalgus deformity (HP:0001848)5.18231480
8Ulnar deviation of the wrist (HP:0003049)5.17584854
9Deformed tarsal bones (HP:0008119)4.74514116
10Aortic aneurysm (HP:0004942)4.55836598
11Shallow orbits (HP:0000586)4.54621265
12Type 1 muscle fiber predominance (HP:0003803)4.37106605
13Papilledema (HP:0001085)4.25999496
14Follicular hyperkeratosis (HP:0007502)4.25704153
15Soft skin (HP:0000977)4.21258524
16Absent phalangeal crease (HP:0006109)4.09018698
17Atrophic scars (HP:0001075)4.07042867
18Cervical subluxation (HP:0003308)3.89672902
19Neonatal short-limb short stature (HP:0008921)3.84715837
20Cerebral aneurysm (HP:0004944)3.84645499
21Bladder diverticulum (HP:0000015)3.81560838
22Spinal rigidity (HP:0003306)3.80122850
23Dilatation of the ascending aorta (HP:0005111)3.72331695
24Trismus (HP:0000211)3.69801740
25Mitral valve prolapse (HP:0001634)3.61929017
26Abnormality of dentin (HP:0010299)3.50991012
27Neoplasm of the heart (HP:0100544)3.45872667
28Abnormal finger flexion creases (HP:0006143)3.43159773
29Slender build (HP:0001533)3.38254942
30Peritonitis (HP:0002586)3.35399805
31Nemaline bodies (HP:0003798)3.33447737
32Wormian bones (HP:0002645)3.30606058
33Fragile skin (HP:0001030)3.29681012
34Wrist flexion contracture (HP:0001239)3.29475091
35Increased connective tissue (HP:0009025)3.27070151
36Biconcave vertebral bodies (HP:0004586)3.18682501
37Vascular tortuosity (HP:0004948)3.18514225
38Abnormality of the calcaneus (HP:0008364)3.18508423
39Chin dimple (HP:0010751)3.18266137
40Blue sclerae (HP:0000592)3.15108821
41Increased variability in muscle fiber diameter (HP:0003557)3.14668509
42Popliteal pterygium (HP:0009756)3.13083680
43Genu recurvatum (HP:0002816)3.09048457
44Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.03609014
45Mildly elevated creatine phosphokinase (HP:0008180)3.03551685
46Vertebral compression fractures (HP:0002953)3.00529288
47Metatarsus adductus (HP:0001840)2.98511614
48Round ear (HP:0100830)2.93341390
49Fetal akinesia sequence (HP:0001989)2.88272462
50Spondylolisthesis (HP:0003302)2.81191738
51Hyperextensible skin (HP:0000974)2.80159045
52Abnormality of skeletal muscle fiber size (HP:0012084)2.78250167
53Muscle fiber inclusion bodies (HP:0100299)2.75328103
54Malignant hyperthermia (HP:0002047)2.71748488
55Osteolytic defects of the hand bones (HP:0009699)2.68979305
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.68979305
57Abnormal delivery (HP:0001787)2.67122096
58Wide anterior fontanel (HP:0000260)2.65306942
59Thin bony cortex (HP:0002753)2.53900381
60Joint laxity (HP:0001388)2.53048396
61Sudden death (HP:0001699)2.52048838
62Broad ribs (HP:0000885)2.47992142
63Arterial tortuosity (HP:0005116)2.46905089
64Elbow flexion contracture (HP:0002987)2.46756032
65Bowel diverticulosis (HP:0005222)2.46540257
66Mitral regurgitation (HP:0001653)2.44781618
67Striae distensae (HP:0001065)2.43343693
68Camptodactyly of toe (HP:0001836)2.43307246
69Bell-shaped thorax (HP:0001591)2.38340492
70Aneurysm (HP:0002617)2.35948023
71Overgrowth (HP:0001548)2.35832995
72Abnormality of the acetabulum (HP:0003170)2.33041995
73Abnormality of the ischium (HP:0003174)2.32214446
74Knee flexion contracture (HP:0006380)2.32086706
75Keratoconus (HP:0000563)2.28369703
76Increased corneal curvature (HP:0100692)2.28369703
77Disproportionate tall stature (HP:0001519)2.27052633
78Mitral stenosis (HP:0001718)2.24175188
79Hyporeflexia of lower limbs (HP:0002600)2.23997830
80Ectopia lentis (HP:0001083)2.23654754
81Aplasia of the musculature (HP:0100854)2.22643481
82Metaphyseal dysplasia (HP:0100255)2.21144314
83Cutaneous syndactyly (HP:0012725)2.20473542
84Hip contracture (HP:0003273)2.16904614
85Breech presentation (HP:0001623)2.13768751
86Aortic regurgitation (HP:0001659)2.11804348
87Osteoarthritis (HP:0002758)2.10313375
88Pulmonary artery stenosis (HP:0004415)2.08894988
89Exercise-induced myalgia (HP:0003738)2.07749952
90Infantile muscular hypotonia (HP:0008947)2.07488312
91Asymmetry of the thorax (HP:0001555)2.05853148
92Lymphangioma (HP:0100764)2.05256127
93Hematochezia (HP:0002573)2.05082316
94Hypoplastic ischia (HP:0003175)2.04648805
95Generalized amyotrophy (HP:0003700)2.02486455
96Deviation of the hallux (HP:0010051)1.99338342
97Mesomelia (HP:0003027)1.98810188
98Tarsal synostosis (HP:0008368)1.98119142
99Symphalangism affecting the phalanges of the hand (HP:0009773)1.97433963
100Osteopenia (HP:0000938)1.95749099
101Hypophosphatemic rickets (HP:0004912)1.94524995
102Syringomyelia (HP:0003396)1.93760120
103Spinal cord lesions (HP:0100561)1.93760120
104Broad long bones (HP:0005622)1.93515966
105Hypoplasia of the iris (HP:0007676)1.93191195
106Flat cornea (HP:0007720)1.92848552
107Femoral bowing (HP:0002980)1.92848261
108Hallux valgus (HP:0001822)1.92035580
109Alopecia of scalp (HP:0002293)1.90031821
110Turricephaly (HP:0000262)1.89646465
111Calf muscle hypertrophy (HP:0008981)1.89606940
112Joint contractures involving the joints of the feet (HP:0100492)1.89391192
113Flexion contracture of toe (HP:0005830)1.89391192
114Limited hip movement (HP:0008800)1.88735180
115Venous abnormality (HP:0002624)1.88188979
116Muscle fiber splitting (HP:0003555)1.87474183
117Lipoatrophy (HP:0100578)1.86954097
118Subacute progressive viral hepatitis (HP:0006572)1.86871680
119Inguinal hernia (HP:0000023)1.85715091
120Short hallux (HP:0010109)1.85592947
121Ulnar bowing (HP:0003031)1.85488080
122Mild short stature (HP:0003502)1.85439207
123Abnormality of the calf musculature (HP:0001430)1.84934588
124Tibial bowing (HP:0002982)1.84413711
125Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83386025
126Short 4th metacarpal (HP:0010044)1.83386025
127Delayed closure of the anterior fontanelle (HP:0001476)1.82554223
128Rectal prolapse (HP:0002035)1.82251129
129Neck muscle weakness (HP:0000467)1.81613711
130Nonimmune hydrops fetalis (HP:0001790)1.81380113
131Right ventricular cardiomyopathy (HP:0011663)1.81309642
132Buphthalmos (HP:0000557)1.81046162
133Aortic valve stenosis (HP:0001650)1.80131661
134Cutaneous finger syndactyly (HP:0010554)1.80021302
135Scapular winging (HP:0003691)1.79372406
136Synostosis involving bones of the lower limbs (HP:0009138)1.79086874
137Synostosis involving bones of the feet (HP:0009140)1.79086874
138Long clavicles (HP:0000890)1.77610818
139Facial diplegia (HP:0001349)1.76309063
140Decreased skull ossification (HP:0004331)1.74393553
141Venous insufficiency (HP:0005293)1.73538714
142Narrow nasal bridge (HP:0000446)1.72827485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.21605335
2TTN3.86557188
3PDGFRA3.73293920
4EPHA33.54866709
5TRIB33.13378008
6TGFBR23.03244814
7SIK13.00828947
8LATS12.70809976
9FRK2.54147590
10NLK2.52082035
11RIPK12.42745252
12MYLK2.37508897
13FER2.05278353
14EPHB21.98784743
15TRPM71.83669791
16DMPK1.80004121
17TIE11.79464921
18PKN21.74910393
19PIK3CA1.72432913
20LATS21.65735793
21AKT31.65345412
22PAK21.57678017
23FGFR21.55929668
24ERBB31.54177640
25STK31.51084292
26ZAK1.49636867
27NEK91.46516004
28PTK2B1.45484651
29MET1.40996993
30PDGFRB1.36344989
31LRRK21.33849446
32MAPK71.33726950
33MAPKAPK31.33502287
34ROCK11.31972058
35GRK11.29809253
36ILK1.23047528
37PAK31.19740162
38CAMK1D1.17118360
39TNIK1.16864529
40PTK61.15834219
41ERN11.13519049
42MAPK121.12639541
43LMTK21.11597620
44JAK11.10984133
45FGFR31.10060424
46MKNK21.08642342
47PRKCH1.05500479
48SGK21.04228892
49PTK21.03046984
50PDK41.01991500
51PDK31.01991500
52PAK40.99783694
53PRKAA20.99520016
54MUSK0.97031273
55EIF2AK30.92630876
56BMX0.91858798
57PRKD20.91326589
58PLK20.90243542
59STK390.87866297
60WNK10.86937717
61FGFR10.85304911
62OBSCN0.82454347
63EPHB10.81702076
64MAP3K60.80777841
65MKNK10.78523427
66FGFR40.77789549
67PDK20.76938443
68NTRK10.75715499
69MOS0.75569072
70ROCK20.74964088
71STK38L0.73587690
72PIK3CG0.71411455
73WNK30.70446411
74NUAK10.70028517
75MST1R0.68711491
76MAPK40.67367842
77CAMK10.66336397
78MTOR0.66096542
79OXSR10.65885363
80CAMK1G0.65655456
81PRKG10.65266722
82LIMK10.64992137
83SGK30.64634857
84CCNB10.64204692
85PRKAA10.63045396
86MARK10.62168790
87TGFBR10.60911092
88FLT30.60897317
89PRKD10.60886602
90SGK2230.60863199
91SGK4940.60863199
92SCYL20.60066486
93BRD40.57499380
94RET0.56747592
95PRKCE0.55593449
96GSK3A0.53231942
97MAP2K10.53182559
98MELK0.52815109
99INSR0.52779718
100PHKG20.52610236
101PHKG10.52610236
102CASK0.51322986
103MARK20.50689570
104MAPKAPK50.49835277
105ADRBK10.49227824
106TESK10.48603816
107EEF2K0.45491911
108CLK10.45313569
109ACVR1B0.43867554
110BRSK20.43685974
111RPS6KA20.43605226
112SRC0.43470397
113ERBB40.43271125
114STK380.42320554
115CSF1R0.41597582
116MAP3K70.41407224
117IGF1R0.40985122
118AKT20.40791392
119PRKD30.40017823
120CDK60.39781989
121CAMK2G0.36591592
122KIT0.35883390
123PRKACB0.34835154
124BMPR1B0.33237082
125CAMK40.32979296
126RPS6KA30.32191676
127MAPK130.31737950
128STK240.30694078
129RPS6KA40.30423846
130ABL10.26090676
131MAP3K100.25844657
132EIF2AK20.24263102
133CHUK0.23508303
134JAK30.23452841
135CDC42BPA0.23051169
136MAPK10.22713480
137GRK50.21646206
138PIM20.19614540
139MAP3K30.19445959
140PAK10.19267630
141ERBB20.15225201
142ABL20.14462809

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.69539177
2Focal adhesion_Homo sapiens_hsa045103.33839148
3Protein digestion and absorption_Homo sapiens_hsa049743.05449707
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.67346242
5Dilated cardiomyopathy_Homo sapiens_hsa054142.60358278
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.42436996
7Amoebiasis_Homo sapiens_hsa051462.33996224
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.32145034
9TGF-beta signaling pathway_Homo sapiens_hsa043502.28756674
10Proteoglycans in cancer_Homo sapiens_hsa052052.21785514
11Adherens junction_Homo sapiens_hsa045202.10670716
12Malaria_Homo sapiens_hsa051442.06797554
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.97795245
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.75526025
15PI3K-Akt signaling pathway_Homo sapiens_hsa041511.64354713
16Small cell lung cancer_Homo sapiens_hsa052221.64157645
17Hippo signaling pathway_Homo sapiens_hsa043901.51261645
18Phototransduction_Homo sapiens_hsa047441.49125211
19Basal cell carcinoma_Homo sapiens_hsa052171.47136944
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.38824897
21Melanoma_Homo sapiens_hsa052181.37166396
22MicroRNAs in cancer_Homo sapiens_hsa052061.37039402
23Viral myocarditis_Homo sapiens_hsa054161.30961053
24Prostate cancer_Homo sapiens_hsa052151.26566623
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25894359
26Regulation of actin cytoskeleton_Homo sapiens_hsa048101.25494303
27Chronic myeloid leukemia_Homo sapiens_hsa052201.20171431
28Renin-angiotensin system_Homo sapiens_hsa046141.18380266
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.14988426
30Circadian rhythm_Homo sapiens_hsa047101.14829520
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14358778
32Hedgehog signaling pathway_Homo sapiens_hsa043401.14294333
33Platelet activation_Homo sapiens_hsa046111.14188560
34Pathways in cancer_Homo sapiens_hsa052001.11514067
35Ovarian steroidogenesis_Homo sapiens_hsa049131.11331754
36Calcium signaling pathway_Homo sapiens_hsa040201.10669406
37Bladder cancer_Homo sapiens_hsa052191.07447943
38Tight junction_Homo sapiens_hsa045301.04605026
39Glioma_Homo sapiens_hsa052141.02932430
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99983468
41Salivary secretion_Homo sapiens_hsa049700.98873872
42Dorso-ventral axis formation_Homo sapiens_hsa043200.97205937
43Pancreatic cancer_Homo sapiens_hsa052120.94227600
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.93226047
45Wnt signaling pathway_Homo sapiens_hsa043100.92865889
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91852683
47Toxoplasmosis_Homo sapiens_hsa051450.91379648
48Circadian entrainment_Homo sapiens_hsa047130.90848058
49Thyroid hormone synthesis_Homo sapiens_hsa049180.88974921
50Rap1 signaling pathway_Homo sapiens_hsa040150.86594433
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85758740
52Insulin resistance_Homo sapiens_hsa049310.84162083
53Axon guidance_Homo sapiens_hsa043600.84047415
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83392951
55Melanogenesis_Homo sapiens_hsa049160.83376603
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80540891
57Mineral absorption_Homo sapiens_hsa049780.78614977
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77459928
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77289955
60Fatty acid metabolism_Homo sapiens_hsa012120.76902566
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.73584244
62PPAR signaling pathway_Homo sapiens_hsa033200.72202311
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71756281
64Insulin secretion_Homo sapiens_hsa049110.71257228
65Endometrial cancer_Homo sapiens_hsa052130.70428926
66Histidine metabolism_Homo sapiens_hsa003400.69809412
67Fatty acid degradation_Homo sapiens_hsa000710.69047149
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.67797917
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65949367
70Estrogen signaling pathway_Homo sapiens_hsa049150.65547725
71Gap junction_Homo sapiens_hsa045400.64926274
72beta-Alanine metabolism_Homo sapiens_hsa004100.64548454
73Tyrosine metabolism_Homo sapiens_hsa003500.64386640
74HTLV-I infection_Homo sapiens_hsa051660.64101500
75Phenylalanine metabolism_Homo sapiens_hsa003600.63585208
76FoxO signaling pathway_Homo sapiens_hsa040680.63445578
77Phagosome_Homo sapiens_hsa041450.63373617
78Renin secretion_Homo sapiens_hsa049240.63066456
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61528085
80Complement and coagulation cascades_Homo sapiens_hsa046100.60823612
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60585293
82AMPK signaling pathway_Homo sapiens_hsa041520.60043067
83Pancreatic secretion_Homo sapiens_hsa049720.59699291
84TNF signaling pathway_Homo sapiens_hsa046680.59391134
85Amphetamine addiction_Homo sapiens_hsa050310.58036071
86Notch signaling pathway_Homo sapiens_hsa043300.57898037
87Renal cell carcinoma_Homo sapiens_hsa052110.57735120
88Colorectal cancer_Homo sapiens_hsa052100.56450796
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56091714
90Insulin signaling pathway_Homo sapiens_hsa049100.54835399
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.53258001
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53043675
93Starch and sucrose metabolism_Homo sapiens_hsa005000.52533235
94Salmonella infection_Homo sapiens_hsa051320.51945557
95p53 signaling pathway_Homo sapiens_hsa041150.51618616
96Nitrogen metabolism_Homo sapiens_hsa009100.51616305
97Tryptophan metabolism_Homo sapiens_hsa003800.51609668
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51505421
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51066759
100Bile secretion_Homo sapiens_hsa049760.50642076
101Ras signaling pathway_Homo sapiens_hsa040140.49428340
102HIF-1 signaling pathway_Homo sapiens_hsa040660.49362697
103Hepatitis B_Homo sapiens_hsa051610.48956938
104Fatty acid biosynthesis_Homo sapiens_hsa000610.48450236
105Cardiac muscle contraction_Homo sapiens_hsa042600.48381827
106Endocytosis_Homo sapiens_hsa041440.46557414
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46256648
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45983046
109GnRH signaling pathway_Homo sapiens_hsa049120.45895785
110Long-term potentiation_Homo sapiens_hsa047200.45719481
111Oxytocin signaling pathway_Homo sapiens_hsa049210.45351704
112Lysine degradation_Homo sapiens_hsa003100.45231823
113mTOR signaling pathway_Homo sapiens_hsa041500.45219217
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44613102
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.43192971
116Propanoate metabolism_Homo sapiens_hsa006400.42753957
117ABC transporters_Homo sapiens_hsa020100.42349835
118Glucagon signaling pathway_Homo sapiens_hsa049220.42349285
119Long-term depression_Homo sapiens_hsa047300.42154735
120Glycerolipid metabolism_Homo sapiens_hsa005610.41492487
121Cocaine addiction_Homo sapiens_hsa050300.41334546
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41092503
123Gastric acid secretion_Homo sapiens_hsa049710.39768969
124Choline metabolism in cancer_Homo sapiens_hsa052310.38401614
125cAMP signaling pathway_Homo sapiens_hsa040240.38164364
126Retinol metabolism_Homo sapiens_hsa008300.38154093
127Prion diseases_Homo sapiens_hsa050200.38006024
128Shigellosis_Homo sapiens_hsa051310.36895313
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35831660
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33500675
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32388912

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