OGT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative thymic T cell selection (GO:0045060)5.17109790
2negative T cell selection (GO:0043383)5.13970784
3regulation of B cell receptor signaling pathway (GO:0050855)4.99869353
4regulation of gamma-delta T cell activation (GO:0046643)4.81118304
5positive T cell selection (GO:0043368)4.74224592
6locomotory exploration behavior (GO:0035641)4.60838677
7B cell receptor signaling pathway (GO:0050853)4.53042890
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.52726793
9positive thymic T cell selection (GO:0045059)4.52511131
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.49567507
11phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.44859229
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.41239767
13response to interleukin-15 (GO:0070672)4.37832549
14negative regulation of erythrocyte differentiation (GO:0045647)4.36103410
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.30414199
16T cell selection (GO:0045058)4.20896388
17antigen processing and presentation of endogenous antigen (GO:0019883)4.20865146
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.17479641
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.15686553
20thymic T cell selection (GO:0045061)4.13769220
21histone H3-K36 demethylation (GO:0070544)4.12458509
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.06880433
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.92248888
24synaptic vesicle maturation (GO:0016188)3.87717171
25regulation of glutamate receptor signaling pathway (GO:1900449)3.85785565
26vocalization behavior (GO:0071625)3.85411150
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.84968035
28positive regulation of B cell differentiation (GO:0045579)3.83788795
29mannose metabolic process (GO:0006013)3.74025198
30negative regulation of cell killing (GO:0031342)3.68487068
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.68487068
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.68405894
33cerebellar Purkinje cell differentiation (GO:0021702)3.65416958
34cellular response to interleukin-15 (GO:0071350)3.65134629
35regulation of B cell differentiation (GO:0045577)3.60433556
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.57453492
37monoubiquitinated protein deubiquitination (GO:0035520)3.55930804
38activated T cell proliferation (GO:0050798)3.54967364
39cellular response to ethanol (GO:0071361)3.51639023
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.50314073
41histone lysine demethylation (GO:0070076)3.41472892
42T cell migration (GO:0072678)3.41471438
43glutamate receptor signaling pathway (GO:0007215)3.38189807
44sodium ion export (GO:0071436)3.36600511
45negative regulation of T cell mediated immunity (GO:0002710)3.36154849
46synaptic transmission, glutamatergic (GO:0035249)3.35664509
47* positive regulation of granulocyte differentiation (GO:0030854)3.35198042
48definitive hemopoiesis (GO:0060216)3.34736667
49positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.33809166
50histone H3-K9 demethylation (GO:0033169)3.32440296
51positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.31547568
52cellular potassium ion homeostasis (GO:0030007)3.31396273
53mucosal-associated lymphoid tissue development (GO:0048537)3.30962657
54Peyers patch development (GO:0048541)3.30962657
55histone demethylation (GO:0016577)3.29092465
56layer formation in cerebral cortex (GO:0021819)3.27737654
57nuclear pore complex assembly (GO:0051292)3.26508700
58synaptic vesicle exocytosis (GO:0016079)3.23595335
59exploration behavior (GO:0035640)3.18676373
60neuron cell-cell adhesion (GO:0007158)3.16729646
61negative regulation of lymphocyte mediated immunity (GO:0002707)3.16460336
62protein localization to synapse (GO:0035418)3.16383903
63regulation of alpha-beta T cell proliferation (GO:0046640)3.14990139
64germinal center formation (GO:0002467)3.13528037
65glial cell proliferation (GO:0014009)3.13428955
66leukocyte aggregation (GO:0070486)3.13206855
67synaptic vesicle endocytosis (GO:0048488)3.13010505
68prepulse inhibition (GO:0060134)3.11321185
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.07272623
70regulation of synaptic vesicle exocytosis (GO:2000300)3.06137914
71mRNA splice site selection (GO:0006376)3.05386933
72positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.04928383
73central nervous system projection neuron axonogenesis (GO:0021952)3.04821513
74establishment of nucleus localization (GO:0040023)3.03865590
75cellular extravasation (GO:0045123)3.01431745
76dendrite morphogenesis (GO:0048813)3.01252879
77neurotransmitter-gated ion channel clustering (GO:0072578)3.00502266
78response to muramyl dipeptide (GO:0032495)2.99741722
79positive regulation of gamma-delta T cell activation (GO:0046645)2.98962562
80neuron-neuron synaptic transmission (GO:0007270)2.98329121
81regulation of synapse structural plasticity (GO:0051823)2.97921734
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97592799
83dendritic spine morphogenesis (GO:0060997)2.97322343
84negative regulation of neurotransmitter secretion (GO:0046929)2.96946679
85* histone H3-K4 trimethylation (GO:0080182)2.96373708
86positive regulation of Rap GTPase activity (GO:0032854)2.96233696
87long-term memory (GO:0007616)2.95475808
88antigen receptor-mediated signaling pathway (GO:0050851)2.92761785
89neurotransmitter secretion (GO:0007269)2.92073414
90regulation of synaptic transmission, glutamatergic (GO:0051966)2.91036411
91regulation of excitatory postsynaptic membrane potential (GO:0060079)2.90251068
92positive regulation of synapse maturation (GO:0090129)2.87494346
93regulation of necroptotic process (GO:0060544)2.86156107
94gamma-aminobutyric acid transport (GO:0015812)2.85846886
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85135785
96T cell homeostasis (GO:0043029)2.84846246
97protein dealkylation (GO:0008214)2.84817863
98protein demethylation (GO:0006482)2.84817863
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.84601159
100glutamate secretion (GO:0014047)2.82672646
101regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.82415813
102auditory behavior (GO:0031223)2.81124476
103regulation of postsynaptic membrane potential (GO:0060078)2.80574995
104phospholipid scrambling (GO:0017121)2.79638859
105axonal fasciculation (GO:0007413)2.78545301
106dosage compensation (GO:0007549)2.78268106
107natural killer cell differentiation (GO:0001779)2.77912675
108postsynaptic membrane organization (GO:0001941)2.77817993
109histone H3-K9 modification (GO:0061647)2.77481606
110B cell homeostasis (GO:0001782)2.77258200
111positive regulation of alpha-beta T cell proliferation (GO:0046641)2.75672248
112nuclear pore organization (GO:0006999)2.75634129
113negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.75398654
114negative regulation of T-helper cell differentiation (GO:0045623)2.75398654
115detection of other organism (GO:0098543)2.75323497
116regulation of dendritic spine morphogenesis (GO:0061001)2.75295500
117presynaptic membrane assembly (GO:0097105)2.74570192
118regulation of neuronal synaptic plasticity (GO:0048168)2.72621486
119detection of bacterium (GO:0016045)2.72034982
120negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70990462
121* regulation of histone H3-K27 methylation (GO:0061085)2.70903104
122regulation of regulatory T cell differentiation (GO:0045589)2.70678350
123regulation of long-term neuronal synaptic plasticity (GO:0048169)2.68740668
124antigen processing and presentation via MHC class Ib (GO:0002475)2.68177391
125interkinetic nuclear migration (GO:0022027)2.67856136
126negative regulation of leukocyte mediated immunity (GO:0002704)2.66808213
127necrotic cell death (GO:0070265)2.66389542
128cerebellar granule cell differentiation (GO:0021707)2.66219086
129negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.65804116
130potassium ion import (GO:0010107)2.65490417
131megakaryocyte development (GO:0035855)2.65323378
132long-term synaptic potentiation (GO:0060291)2.65094585
133JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.64968690
134response to auditory stimulus (GO:0010996)2.63651482
135regulation of ARF protein signal transduction (GO:0032012)2.62689138
136regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62507863
137membrane hyperpolarization (GO:0060081)2.62491893
138negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.62326708
139hepatocyte apoptotic process (GO:0097284)2.62254172
140L-amino acid import (GO:0043092)2.62113639
141positive regulation by symbiont of host defense response (GO:0052509)2.61873552
142modulation by symbiont of host defense response (GO:0052031)2.61873552
143modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.61873552
144modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.61873552
145positive regulation by organism of defense response of other organism involved in symbiotic interact2.61873552
146modulation by symbiont of host immune response (GO:0052553)2.61873552
147regulation of synaptic vesicle transport (GO:1902803)2.61847662
148negative regulation of translation, ncRNA-mediated (GO:0040033)2.61591804
149regulation of translation, ncRNA-mediated (GO:0045974)2.61591804
150negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61591804
151membrane depolarization during action potential (GO:0086010)2.61546197
152regulation of RNA export from nucleus (GO:0046831)2.61099262
153T cell receptor signaling pathway (GO:0050852)2.59601291
154response to histamine (GO:0034776)2.59293731
155striatum development (GO:0021756)2.58276581
156interferon-gamma production (GO:0032609)2.57934424
157cell differentiation in hindbrain (GO:0021533)2.57607006
158regulation of Rap GTPase activity (GO:0032317)2.57283536
159mechanosensory behavior (GO:0007638)2.56685677
160histone deubiquitination (GO:0016578)2.56496292
161negative regulation of glycoprotein biosynthetic process (GO:0010561)2.54976534
162negative regulation of B cell proliferation (GO:0030889)2.54833846
163innervation (GO:0060384)2.54789514
164CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.53938653
165regulation of interleukin-2 biosynthetic process (GO:0045076)2.53839930
166negative regulation of adaptive immune response (GO:0002820)2.52672408
167positive regulation of tolerance induction (GO:0002645)2.52124523
168* histone H3-K4 methylation (GO:0051568)2.51214955
169neuronal ion channel clustering (GO:0045161)2.50695219
170positive regulation of membrane potential (GO:0045838)2.49483411
171neuromuscular process controlling balance (GO:0050885)2.48017980
172neuronal action potential propagation (GO:0019227)2.47500581
173visual learning (GO:0008542)2.47469073
174transmission of nerve impulse (GO:0019226)2.47199424
175cellular sodium ion homeostasis (GO:0006883)2.46852667
176G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.46347476
177cytoplasmic mRNA processing body assembly (GO:0033962)2.46321976
178behavioral defense response (GO:0002209)2.46145517
179behavioral fear response (GO:0001662)2.46145517
180cell communication by electrical coupling (GO:0010644)2.45709904
181neuron recognition (GO:0008038)2.45161626
182regulation of respiratory system process (GO:0044065)2.44722389
183presynaptic membrane organization (GO:0097090)2.44298694
184negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.44208144
185retrograde transport, vesicle recycling within Golgi (GO:0000301)2.40657203
186regulation of gamma-delta T cell differentiation (GO:0045586)2.40371204
187positive regulation of dendritic spine morphogenesis (GO:0061003)2.40027456
188membrane depolarization (GO:0051899)2.39444317
189clathrin coat assembly (GO:0048268)2.38830101
190negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.37162945
191regulation of synaptic plasticity (GO:0048167)2.35705568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.63190601
2EZH2_22144423_ChIP-Seq_EOC_Human4.20741830
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.96321520
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99391778
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.98134765
6MYB_26560356_Chip-Seq_TH2_Human2.85126514
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83465667
8GBX2_23144817_ChIP-Seq_PC3_Human2.82222418
9DROSHA_22980978_ChIP-Seq_HELA_Human2.74194706
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.67048745
11GATA1_22025678_ChIP-Seq_K562_Human2.57324043
12MYB_26560356_Chip-Seq_TH1_Human2.51564688
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46345339
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.46150053
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.42840233
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42452345
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.40181352
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.31552617
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25333226
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25091955
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24991834
22* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22539731
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.17018628
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13051237
25EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11922366
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11922366
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11642400
28MAF_26560356_Chip-Seq_TH1_Human2.11120267
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05510456
30SMAD_19615063_ChIP-ChIP_OVARY_Human2.05230365
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04123649
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03790599
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02909261
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97736676
35* GATA3_27048872_Chip-Seq_THYMUS_Human1.95616048
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.89456575
37AR_21572438_ChIP-Seq_LNCaP_Human1.88342280
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87857445
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86412554
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86193237
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81849182
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.80545122
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80475731
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.80153951
45SPI1_23127762_ChIP-Seq_K562_Human1.79028227
46REST_21632747_ChIP-Seq_MESCs_Mouse1.76937803
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.73675164
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72581366
49UTX_26944678_Chip-Seq_JUKART_Human1.72287083
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.72174647
51CIITA_25753668_ChIP-Seq_RAJI_Human1.67456344
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65288263
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64382298
54VDR_24763502_ChIP-Seq_THP-1_Human1.62265952
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60738583
56SPI1_23547873_ChIP-Seq_NB4_Human1.60187788
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59343407
58EED_16625203_ChIP-ChIP_MESCs_Mouse1.59166190
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58544105
60RUNX_20019798_ChIP-Seq_JUKART_Human1.56336575
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.54018280
62* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.53235645
63* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52966261
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51152993
65TP53_16413492_ChIP-PET_HCT116_Human1.50810493
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50238894
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.49953560
68VDR_21846776_ChIP-Seq_THP-1_Human1.48655883
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.48145815
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47092933
71AHR_22903824_ChIP-Seq_MCF-7_Human1.46159634
72VDR_24787735_ChIP-Seq_THP-1_Human1.44407684
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43610902
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43396155
75SMAD4_21799915_ChIP-Seq_A2780_Human1.42731673
76MAF_26560356_Chip-Seq_TH2_Human1.39855994
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39356304
78PU_27001747_Chip-Seq_BMDM_Mouse1.34916860
79AR_19668381_ChIP-Seq_PC3_Human1.34750389
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34548655
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.33819572
82REST_18959480_ChIP-ChIP_MESCs_Mouse1.33794243
83* SOX2_21211035_ChIP-Seq_LN229_Gbm1.31311770
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.29669058
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.29592898
86* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28969262
87GATA1_19941826_ChIP-Seq_K562_Human1.28275579
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.28133071
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27833993
90ZFP281_27345836_Chip-Seq_ESCs_Mouse1.27781470
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26520727
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25223446
93* GATA3_26560356_Chip-Seq_TH2_Human1.25215209
94TAF15_26573619_Chip-Seq_HEK293_Human1.24920419
95STAT3_23295773_ChIP-Seq_U87_Human1.24479002
96SCL_19346495_ChIP-Seq_HPC-7_Human1.24147556
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24008005
98GATA2_19941826_ChIP-Seq_K562_Human1.23885552
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23611945
100KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23202875
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22901057
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22901057
103DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22303976
104* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22276614
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21692407
106CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20101796
107GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18895787
108SALL1_21062744_ChIP-ChIP_HESCs_Human1.18859994
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17970878
110KDM2B_26808549_Chip-Seq_JURKAT_Human1.17961675
111KDM2B_26808549_Chip-Seq_DND41_Human1.16718281
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.15932584
113CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15603715
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.14636042
115GATA1_19941827_ChIP-Seq_MEL_Mouse1.14290406
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.13993903
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12318523
118KDM2B_26808549_Chip-Seq_K562_Human1.11335184
119TCF4_23295773_ChIP-Seq_U87_Human1.10577624
120FUS_26573619_Chip-Seq_HEK293_Human1.10320829
121AR_25329375_ChIP-Seq_VCAP_Human1.09563539
122GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09248252
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08796001
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08698283
125ERG_21242973_ChIP-ChIP_JURKAT_Human1.08202681
126RING1B_27294783_Chip-Seq_ESCs_Mouse1.08150677
127P300_19829295_ChIP-Seq_ESCs_Human1.08032988
128TCF7_22412390_ChIP-Seq_EML_Mouse1.07153411
129FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06164614
130ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06157497
131KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05876973
132SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05643693
133RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04631675
134CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03360684
135P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03267261
136RXR_22108803_ChIP-Seq_LS180_Human1.03152074
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02911506
138RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02623495
139PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02610334
140EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02516453
141SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02397371
142PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99671711
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.98285259
144MYC_22102868_ChIP-Seq_BL_Human0.97899136
145RING1B_27294783_Chip-Seq_NPCs_Mouse0.97506963
146FOXA2_19822575_ChIP-Seq_HepG2_Human0.97152046
147MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97096178
148FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96150897
149RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95842697
150ZNF274_21170338_ChIP-Seq_K562_Hela0.95411849
151OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95073033
152TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94995613
153PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91665168
154NCOR1_26117541_ChIP-Seq_K562_Human0.91444225
155NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89104655
156ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88899328
157GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88326946
158MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86210502
159WT1_19549856_ChIP-ChIP_CCG9911_Human0.85772916
160RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81195085
161STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78652674
162FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78287922
163SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77521621
164SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76347746
165* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.75073822
166SMRT_27268052_Chip-Seq_Bcells_Human0.74941823
167SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74694662
168RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.74228816
169* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73899718
170* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73185563
171NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.73169231
172RUNX1_27514584_Chip-Seq_MCF-7_Human0.73162251
173ETS1_22383799_ChIP-Seq_G1ME_Mouse0.72396127
174CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.72008391

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.56497392
2MP0000569_abnormal_digit_pigmentation4.72909532
3MP0002009_preneoplasia4.16102042
4MP0008057_abnormal_DNA_replication4.09709384
5MP0003635_abnormal_synaptic_transmissio3.41675389
6MP0001835_abnormal_antigen_presentation3.36227493
7MP0003787_abnormal_imprinting3.23481447
8MP0003880_abnormal_central_pattern2.96864462
9MP0001800_abnormal_humoral_immune2.73926601
10MP0009745_abnormal_behavioral_response2.71284351
11MP0002063_abnormal_learning/memory/cond2.63494892
12MP0005423_abnormal_somatic_nervous2.56047746
13MP0003436_decreased_susceptibility_to2.54768143
14MP0001486_abnormal_startle_reflex2.39698872
15MP0002064_seizures2.38859968
16MP0009046_muscle_twitch2.34630884
17MP0008569_lethality_at_weaning2.33876564
18MP0000685_abnormal_immune_system2.29043811
19MP0002572_abnormal_emotion/affect_behav2.28118190
20MP0002822_catalepsy2.24940921
21* MP0000703_abnormal_thymus_morphology2.22794218
22* MP0002398_abnormal_bone_marrow2.19079883
23MP0004270_analgesia2.17585105
24MP0004885_abnormal_endolymph2.10013762
25MP0005000_abnormal_immune_tolerance2.09686607
26MP0005671_abnormal_response_to2.08035706
27MP0001790_abnormal_immune_system2.05057709
28MP0005387_immune_system_phenotype2.05057709
29MP0002006_tumorigenesis2.04463742
30* MP0002420_abnormal_adaptive_immunity2.03815564
31MP0002723_abnormal_immune_serum2.00692266
32* MP0001819_abnormal_immune_cell1.99489610
33MP0004381_abnormal_hair_follicle1.99089789
34MP0000778_abnormal_nervous_system1.98683041
35MP0002452_abnormal_antigen_presenting1.88225100
36MP0002405_respiratory_system_inflammati1.83287084
37* MP0000716_abnormal_immune_system1.81902479
38MP0002272_abnormal_nervous_system1.80748565
39MP0003724_increased_susceptibility_to1.79360122
40MP0000689_abnormal_spleen_morphology1.78836609
41MP0002722_abnormal_immune_system1.78422982
42MP0002067_abnormal_sensory_capabilities1.73169629
43MP0003303_peritoneal_inflammation1.69293109
44MP0002419_abnormal_innate_immunity1.66295525
45MP0005025_abnormal_response_to1.65958118
46MP0010155_abnormal_intestine_physiology1.65817907
47MP0001501_abnormal_sleep_pattern1.65785024
48MP0005451_abnormal_body_composition1.64681428
49MP0005174_abnormal_tail_pigmentation1.63032085
50MP0003656_abnormal_erythrocyte_physiolo1.62457982
51MP0001968_abnormal_touch/_nociception1.61581247
52MP0005646_abnormal_pituitary_gland1.61478420
53MP0009780_abnormal_chondrocyte_physiolo1.61256293
54MP0002557_abnormal_social/conspecific_i1.61144514
55MP0001502_abnormal_circadian_rhythm1.55341511
56MP0005409_darkened_coat_color1.52947637
57MP0002184_abnormal_innervation1.51099407
58MP0004947_skin_inflammation1.48615080
59* MP0002429_abnormal_blood_cell1.47432088
60MP0008961_abnormal_basal_metabolism1.46841409
61MP0005310_abnormal_salivary_gland1.46263754
62MP0004924_abnormal_behavior1.46034972
63MP0005386_behavior/neurological_phenoty1.46034972
64MP0003121_genomic_imprinting1.44068997
65MP0005076_abnormal_cell_differentiation1.42530742
66MP0004811_abnormal_neuron_physiology1.41321913
67MP0001851_eye_inflammation1.35962947
68MP0003828_pulmonary_edema1.31953247
69MP0000955_abnormal_spinal_cord1.31876758
70MP0001440_abnormal_grooming_behavior1.29200900
71MP0001984_abnormal_olfaction1.28237233
72MP0009333_abnormal_splenocyte_physiolog1.28179081
73MP0002734_abnormal_mechanical_nocicepti1.27202897
74MP0002882_abnormal_neuron_morphology1.24838664
75MP0003091_abnormal_cell_migration1.24562867
76MP0002152_abnormal_brain_morphology1.19061214
77MP0005397_hematopoietic_system_phenotyp1.18931490
78MP0001545_abnormal_hematopoietic_system1.18931490
79MP0010352_gastrointestinal_tract_polyps1.17452969
80MP0003172_abnormal_lysosome_physiology1.17113311
81MP0003122_maternal_imprinting1.16541040
82MP0001188_hyperpigmentation1.15104565
83MP0004264_abnormal_extraembryonic_tissu1.14334955
84MP0005464_abnormal_platelet_physiology1.13455735
85MP0002909_abnormal_adrenal_gland1.13162231
86MP0005394_taste/olfaction_phenotype1.12709481
87MP0005499_abnormal_olfactory_system1.12709481
88MP0005075_abnormal_melanosome_morpholog1.12390982
89MP0001845_abnormal_inflammatory_respons1.08633870
90MP0002735_abnormal_chemical_nociception1.08556339
91MP0004858_abnormal_nervous_system1.08503744
92MP0003633_abnormal_nervous_system1.07924227
93MP0010234_abnormal_vibrissa_follicle1.07325506
94MP0009785_altered_susceptibility_to1.07315123
95MP0002933_joint_inflammation1.07161113
96MP0008260_abnormal_autophagy1.06963335
97MP0002089_abnormal_postnatal_growth/wei1.04613940
98MP0005551_abnormal_eye_electrophysiolog1.00353251
99MP0004808_abnormal_hematopoietic_stem0.99240439
100MP0002736_abnormal_nociception_after0.98148413
101MP0003045_fibrosis0.97023549
102MP0001970_abnormal_pain_threshold0.95893871
103MP0000631_abnormal_neuroendocrine_gland0.95861318
104* MP0002066_abnormal_motor_capabilities/c0.95427969
105MP0001853_heart_inflammation0.95101824
106MP0002733_abnormal_thermal_nociception0.93585036
107MP0003183_abnormal_peptide_metabolism0.92316096
108MP0006072_abnormal_retinal_apoptosis0.92043634
109MP0005187_abnormal_penis_morphology0.91258497
110MP0002019_abnormal_tumor_incidence0.90752651
111MP0009115_abnormal_fat_cell0.89720960
112MP0010307_abnormal_tumor_latency0.88899074
113MP0008995_early_reproductive_senescence0.88654035
114MP0003879_abnormal_hair_cell0.87555946
115MP0003861_abnormal_nervous_system0.87087612
116MP0009278_abnormal_bone_marrow0.86941026
117MP0003631_nervous_system_phenotype0.86648973
118MP0005220_abnormal_exocrine_pancreas0.85903971
119MP0003763_abnormal_thymus_physiology0.85788899
120MP0006292_abnormal_olfactory_placode0.85082438
121MP0004883_abnormal_blood_vessel0.84839118
122MP0002396_abnormal_hematopoietic_system0.84571572
123MP0005621_abnormal_cell_physiology0.84465912
124MP0001177_atelectasis0.83825806
125MP0003300_gastrointestinal_ulcer0.82682955
126MP0002998_abnormal_bone_remodeling0.82202185
127MP0000465_gastrointestinal_hemorrhage0.80738982
128MP0004185_abnormal_adipocyte_glucose0.80005893
129MP0010678_abnormal_skin_adnexa0.79813029
130MP0004484_altered_response_of0.78635831
131MP0002132_abnormal_respiratory_system0.78379355
132MP0005666_abnormal_adipose_tissue0.78118237
133MP0003632_abnormal_nervous_system0.76968680
134MP0006082_CNS_inflammation0.76143342
135MP0000015_abnormal_ear_pigmentation0.75328495
136MP0004130_abnormal_muscle_cell0.75297116
137MP0001299_abnormal_eye_distance/0.75081429
138MP0001873_stomach_inflammation0.74726219
139MP0001533_abnormal_skeleton_physiology0.74448425
140MP0000751_myopathy0.74386921
141MP0004142_abnormal_muscle_tone0.74316218
142MP0002166_altered_tumor_susceptibility0.74214801
143MP0003943_abnormal_hepatobiliary_system0.72996622
144MP0003115_abnormal_respiratory_system0.72398171
145MP0002095_abnormal_skin_pigmentation0.72343414
146MP0003634_abnormal_glial_cell0.72209806
147MP0005645_abnormal_hypothalamus_physiol0.71736728
148MP0003690_abnormal_glial_cell0.71711568
149MP0000858_altered_metastatic_potential0.71304898
150MP0003221_abnormal_cardiomyocyte_apopto0.71301439
151MP0003283_abnormal_digestive_organ0.70999407
152* MP0010769_abnormal_survival0.70829163
153MP0001915_intracranial_hemorrhage0.69676486
154MP0000428_abnormal_craniofacial_morphol0.68755637
155MP0004742_abnormal_vestibular_system0.68478180
156* MP0010770_preweaning_lethality0.67245655
157* MP0002082_postnatal_lethality0.67245655
158* MP0010768_mortality/aging0.66727058
159MP0001943_abnormal_respiration0.66661731
160MP0005375_adipose_tissue_phenotype0.66630507
161MP0002693_abnormal_pancreas_physiology0.66619896
162MP0004215_abnormal_myocardial_fiber0.66576051
163MP0002086_abnormal_extraembryonic_tissu0.66509252
164MP0001270_distended_abdomen0.64884126
165MP0002229_neurodegeneration0.63108145
166MP0003935_abnormal_craniofacial_develop0.63092801
167MP0002168_other_aberrant_phenotype0.62693713
168MP0003866_abnormal_defecation0.62610048
169MP0003984_embryonic_growth_retardation0.62369081
170MP0000371_diluted_coat_color0.62177490
171MP0000383_abnormal_hair_follicle0.62028715
172MP0004145_abnormal_muscle_electrophysio0.61965935
173MP0002088_abnormal_embryonic_growth/wei0.61190915
174MP0001348_abnormal_lacrimal_gland0.60171476
175MP0000003_abnormal_adipose_tissue0.59602233
176MP0008469_abnormal_protein_level0.59146399
177MP0006054_spinal_hemorrhage0.57461858
178MP0002925_abnormal_cardiovascular_devel0.55921129
179* MP0000350_abnormal_cell_proliferation0.55281502
180MP0002970_abnormal_white_adipose0.55076792
181MP0001784_abnormal_fluid_regulation0.53147224

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.03329160
2Abnormal delayed hypersensitivity skin test (HP:0002963)3.99244515
3Eczematoid dermatitis (HP:0000976)3.78948499
4Abnormality of T cell number (HP:0011839)3.70650679
5Focal motor seizures (HP:0011153)3.66101954
6Recurrent viral infections (HP:0004429)3.51424595
7Colitis (HP:0002583)3.50543322
8Recurrent fungal infections (HP:0002841)3.38744569
9Focal seizures (HP:0007359)3.27550630
10Macroorchidism (HP:0000053)3.21604381
11Febrile seizures (HP:0002373)3.20085482
12Recurrent cutaneous fungal infections (HP:0011370)3.10377293
13Chronic mucocutaneous candidiasis (HP:0002728)3.10377293
14Epileptic encephalopathy (HP:0200134)3.07708940
15Viral hepatitis (HP:0006562)3.05959719
16Papilledema (HP:0001085)3.05315920
17Abnormality of the fingertips (HP:0001211)3.03639320
18Broad-based gait (HP:0002136)3.01178872
19Progressive cerebellar ataxia (HP:0002073)3.00247470
20Recurrent bacterial skin infections (HP:0005406)2.95697175
21Gastrointestinal infarctions (HP:0005244)2.95149980
22Abnormality of T cells (HP:0002843)2.93833356
23Inflammation of the large intestine (HP:0002037)2.90741067
24Agammaglobulinemia (HP:0004432)2.87811415
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.85653442
26Gastrointestinal inflammation (HP:0004386)2.83823612
27Subacute progressive viral hepatitis (HP:0006572)2.82062879
28Narrow palate (HP:0000189)2.78144274
29Meningitis (HP:0001287)2.74230030
30Chronic diarrhea (HP:0002028)2.68639038
31Recurrent abscess formation (HP:0002722)2.67997946
32Gaze-evoked nystagmus (HP:0000640)2.67359353
33Spontaneous hematomas (HP:0007420)2.66922194
34Autoimmune hemolytic anemia (HP:0001890)2.66827693
35Truncal ataxia (HP:0002078)2.65412560
36Pustule (HP:0200039)2.61779408
37Genetic anticipation (HP:0003743)2.61175707
38Myositis (HP:0100614)2.61099368
39Severe combined immunodeficiency (HP:0004430)2.58452284
40Acute myeloid leukemia (HP:0004808)2.55459031
41Obsessive-compulsive behavior (HP:0000722)2.55194630
42Granulocytopenia (HP:0001913)2.49496939
43Abnormality of ocular smooth pursuit (HP:0000617)2.46424759
44Impaired smooth pursuit (HP:0007772)2.44642073
45Short 4th metacarpal (HP:0010044)2.43158435
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.43158435
47Abnormality of T cell physiology (HP:0011840)2.42410334
48Vasculitis (HP:0002633)2.41583383
49Basal cell carcinoma (HP:0002671)2.40991123
50Hyperacusis (HP:0010780)2.40894942
51Recurrent skin infections (HP:0001581)2.40883465
52Hemiplegia (HP:0002301)2.40763779
53Increased IgE level (HP:0003212)2.38269448
54Chest pain (HP:0100749)2.36277022
55Slow saccadic eye movements (HP:0000514)2.33338059
56Protruding tongue (HP:0010808)2.33275481
57Action tremor (HP:0002345)2.33098558
58Trigonocephaly (HP:0000243)2.32748243
59Pointed chin (HP:0000307)2.32535649
60Dysmetric saccades (HP:0000641)2.32074796
61Volvulus (HP:0002580)2.32025027
62Lymphopenia (HP:0001888)2.31366853
63Recurrent bronchitis (HP:0002837)2.31307725
64Fatigue (HP:0012378)2.31183211
65Prolonged bleeding time (HP:0003010)2.30580592
66Heterotopia (HP:0002282)2.29600646
67Encephalitis (HP:0002383)2.28744839
68Myokymia (HP:0002411)2.28476675
69Stereotypic behavior (HP:0000733)2.28178988
70Impaired social interactions (HP:0000735)2.27547728
71Abnormal social behavior (HP:0012433)2.27547728
72Mediastinal lymphadenopathy (HP:0100721)2.25316423
73Optic neuritis (HP:0100653)2.25082433
74Retrobulbar optic neuritis (HP:0100654)2.25082433
75Sandal gap (HP:0001852)2.24775437
76Hypoplasia of the thymus (HP:0000778)2.24379090
77Scanning speech (HP:0002168)2.23671227
78Urinary bladder sphincter dysfunction (HP:0002839)2.23142935
79Absent frontal sinuses (HP:0002688)2.22739438
80Cellulitis (HP:0100658)2.21770848
81Dislocated radial head (HP:0003083)2.21436797
82Abnormality of cells of the lymphoid lineage (HP:0012140)2.20431009
83Acute lymphatic leukemia (HP:0006721)2.19689648
84Gingivitis (HP:0000230)2.18832034
85Elfin facies (HP:0004428)2.16932281
86Drooling (HP:0002307)2.15305772
87Excessive salivation (HP:0003781)2.15305772
88Postural instability (HP:0002172)2.15030658
89Neoplasm of the heart (HP:0100544)2.14149369
90Visual hallucinations (HP:0002367)2.13951411
91Poor eye contact (HP:0000817)2.12577959
92Abnormality of binocular vision (HP:0011514)2.12003248
93Diplopia (HP:0000651)2.12003248
94Orchitis (HP:0100796)2.11043421
95Neoplasm of the tracheobronchial system (HP:0100552)2.08325070
96Prominent nose (HP:0000448)2.08042532
97Tented upper lip vermilion (HP:0010804)2.07427390
98Arterial thrombosis (HP:0004420)2.06968784
99Panhypogammaglobulinemia (HP:0003139)2.04729564
100Depressed nasal tip (HP:0000437)2.01676382
101Osteomyelitis (HP:0002754)2.01333595
102Submucous cleft hard palate (HP:0000176)2.00851293
103Verrucae (HP:0200043)2.00399289
104Papilloma (HP:0012740)2.00399289
105Leukocytosis (HP:0001974)1.99440360
106Urinary urgency (HP:0000012)1.99434857
107Impaired vibration sensation in the lower limbs (HP:0002166)1.96333290
108Abnormality of the radial head (HP:0003995)1.95984981
109Hepatitis (HP:0012115)1.95931246
110Aqueductal stenosis (HP:0002410)1.95262640
111Combined immunodeficiency (HP:0005387)1.95101880
112Spinal cord lesions (HP:0100561)1.93931666
113Syringomyelia (HP:0003396)1.93931666
114Dysdiadochokinesis (HP:0002075)1.93884801
115Broad face (HP:0000283)1.93175919
116Eosinophilia (HP:0001880)1.92657752
117Pulmonary infiltrates (HP:0002113)1.92400707
118Atonic seizures (HP:0010819)1.91493002
119Stomatitis (HP:0010280)1.89494335
120Neonatal hypoglycemia (HP:0001998)1.87424219
121Broad metatarsal (HP:0001783)1.87200998
122Abnormal hair whorl (HP:0010721)1.86859235
123Epistaxis (HP:0000421)1.86613761
124Depression (HP:0000716)1.86098636
125Inappropriate behavior (HP:0000719)1.86032732
126IgM deficiency (HP:0002850)1.85575582
127Gingival bleeding (HP:0000225)1.85177728
128Aplasia involving bones of the extremities (HP:0009825)1.84578249
129Aplasia involving bones of the upper limbs (HP:0009823)1.84578249
130Aplasia of the phalanges of the hand (HP:0009802)1.84578249
131Truncal obesity (HP:0001956)1.83633813
132Hematochezia (HP:0002573)1.83549470
133Abnormality of the astrocytes (HP:0100707)1.83096125
134Astrocytoma (HP:0009592)1.83096125
135Elevated erythrocyte sedimentation rate (HP:0003565)1.82804451
136Abnormality of oral frenula (HP:0000190)1.82445213
137Abnormality of eosinophils (HP:0001879)1.78338053
138Somatic mutation (HP:0001428)1.78188304
139IgA deficiency (HP:0002720)1.77275380
140Abnormality of the peritoneum (HP:0002585)1.77259171
141Absence seizures (HP:0002121)1.76867313
142Insomnia (HP:0100785)1.76862184
1432-3 toe syndactyly (HP:0004691)1.76710995
144Papillary thyroid carcinoma (HP:0002895)1.75473930
145Widely spaced teeth (HP:0000687)1.75347065
146Hemoptysis (HP:0002105)1.75073261
147Pulmonary embolism (HP:0002204)1.74954620
148Ankle clonus (HP:0011448)1.74764681
149Hemiparesis (HP:0001269)1.74657347
150Deeply set eye (HP:0000490)1.74347944
151Thyroiditis (HP:0100646)1.73836597
152Testicular neoplasm (HP:0010788)1.73801158
153Anteriorly placed anus (HP:0001545)1.73199423
154Ependymoma (HP:0002888)1.73159562
155Supranuclear gaze palsy (HP:0000605)1.72581123
156Tapered finger (HP:0001182)1.72356566
157Open mouth (HP:0000194)1.71761069
158Alveolar cell carcinoma (HP:0006519)1.71738073
159Abnormality of the 4th metacarpal (HP:0010012)1.71468470
160Midline defect of the nose (HP:0004122)1.70580979
161Keratoconjunctivitis sicca (HP:0001097)1.70520670
162Long eyelashes (HP:0000527)1.69815065
163Anal stenosis (HP:0002025)1.69533308
164Coarse hair (HP:0002208)1.68946943
165Ankyloglossia (HP:0010296)1.68619454
166Megalencephaly (HP:0001355)1.68559706
167Overriding aorta (HP:0002623)1.68136218
168Acute hepatic failure (HP:0006554)1.66629340
169Renovascular hypertension (HP:0100817)1.65553010
170Absent speech (HP:0001344)1.64794772
171Annular pancreas (HP:0001734)1.64244910
172Intention tremor (HP:0002080)1.64054857
173Neoplasm of the oral cavity (HP:0100649)1.63377289
174Hyperventilation (HP:0002883)1.63104957
175Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62991367
176Narrow nasal bridge (HP:0000446)1.62520413
177Thick eyebrow (HP:0000574)1.60986458
178Autism (HP:0000717)1.60717309
179Abnormality of the lower motor neuron (HP:0002366)1.60341078
180Attention deficit hyperactivity disorder (HP:0007018)1.59251230
181Sacral dimple (HP:0000960)1.57765989
182Dialeptic seizures (HP:0011146)1.57438922
183Vertebral arch anomaly (HP:0008438)1.57000127
184Broad palm (HP:0001169)1.56920316
185Abnormality of the nasal septum (HP:0000419)1.56680518
186Glioma (HP:0009733)1.55326022
187Oligodactyly (hands) (HP:0001180)1.55114231
188Hypoplasia of the maxilla (HP:0000327)1.55108043
189Dysmetria (HP:0001310)1.54824363

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.37656654
2NTRK33.16626727
3TNIK2.99804417
4SIK22.87644010
5TYK22.34026642
6NTRK22.32958796
7BRD42.30924076
8MAP3K42.20885157
9CAMK1G2.19458207
10FGFR42.13034703
11EEF2K2.03357086
12TRIB31.91597952
13MAP3K141.90210497
14MAP3K131.83131746
15MAP3K91.78319835
16AKT31.76961383
17SGK21.76689255
18DAPK21.76114618
19BLK1.75735700
20BTK1.72207356
21SGK31.67523714
22KSR11.66881415
23BMPR21.63180768
24TXK1.59809234
25MAP3K71.58237263
26CAMK1D1.58012325
27FGFR21.57485312
28PRPF4B1.54198223
29PAK61.52753702
30NLK1.49953167
31MARK11.48957823
32TEC1.48950992
33TRPM71.44634607
34TAOK31.44033997
35RIPK41.43691132
36ZAP701.42876002
37MAP2K71.36421129
38MAP2K31.31369688
39MAP3K21.31226902
40IKBKE1.30699314
41FES1.27043137
42MAPK131.25940950
43MARK21.25557497
44SGK2231.24832677
45SGK4941.24832677
46CDK121.23581452
47IRAK41.19989738
48CDK191.18919167
49PRKCH1.18493506
50FRK1.18414822
51TYRO31.17017706
52CAMKK11.16776138
53RIPK11.15678379
54CDK61.12316142
55SIK31.11726033
56CAMK11.10853249
57CSK1.09672613
58MINK11.09072316
59KSR21.08784506
60PASK1.08186717
61STK381.03188497
62JAK21.03152470
63DYRK1A1.01703975
64MAPK111.01005202
65CDK50.99667592
66SMG10.99198150
67FGFR30.97894610
68WNK10.96068405
69SGK10.95203369
70CAMK40.94913846
71GRK60.93776274
72DAPK10.92864351
73SIK10.90485995
74CDC42BPA0.90285577
75ERBB30.89766606
76MAP2K40.89737878
77EPHA30.87630738
78EIF2AK30.86444589
79CDK40.83155541
80ERN10.82918972
81CAMKK20.82731657
82PNCK0.81653390
83MELK0.81387648
84MAP3K60.81049481
85KIT0.80924683
86YES10.79393542
87MAP4K10.77327016
88PIK3CG0.75331029
89EPHB10.75280116
90LYN0.73871557
91MAP3K100.73015958
92ICK0.71763047
93PHKG20.71273931
94PHKG10.71273931
95FGFR10.71125107
96HCK0.70016107
97IRAK10.69629858
98PDGFRB0.68788789
99CASK0.68712831
100RET0.67808989
101PDGFRA0.66894354
102CDK30.66409265
103TNK20.66381771
104CSNK1A1L0.66017154
105STK110.65893937
106JAK10.65443901
107RPS6KB20.64586035
108FYN0.62784179
109MAPK70.62394640
110UHMK10.61563884
111MAPK100.59728999
112MARK30.59678687
113RAF10.58032638
114MAPK120.56816159
115LMTK20.56416424
116PTK60.55356456
117RPS6KA30.55266125
118MAPK80.55170114
119TAOK20.54543323
120HIPK20.51702757
121TBK10.51205170
122MTOR0.50938851
123PRKD20.50932229
124NEK60.49459900
125JAK30.49414520
126PRKAA20.49334943
127CSNK1G20.48931942
128PDK10.48563954
129MKNK20.48263193
130PRKCQ0.47910841
131MAP3K10.47371817
132IKBKB0.47075876
133FGR0.46834367
134NEK90.46201285
135TTN0.45734409
136ALK0.45443042
137MAP2K60.44992147
138ITK0.44766025
139GSK3B0.43924225
140PRKCG0.43671089
141RPS6KA20.43467213
142SYK0.43453547
143ERBB20.42518663
144PRKD30.42494055
145PKN20.42417861
146LCK0.41441831
147CSF1R0.41051397
148TAOK10.40764394
149SRC0.40221113
150MAPK90.39605663
151DMPK0.39474839

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.63642200
2Circadian entrainment_Homo sapiens_hsa047132.11092743
3Long-term potentiation_Homo sapiens_hsa047202.00642180
4Glutamatergic synapse_Homo sapiens_hsa047241.99844541
5Morphine addiction_Homo sapiens_hsa050321.96748544
6Olfactory transduction_Homo sapiens_hsa047401.95574614
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.92164008
8GABAergic synapse_Homo sapiens_hsa047271.84294946
9Measles_Homo sapiens_hsa051621.71627883
10Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67416692
11Salivary secretion_Homo sapiens_hsa049701.67246121
12Leishmaniasis_Homo sapiens_hsa051401.61402044
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.60136513
14Amphetamine addiction_Homo sapiens_hsa050311.51330038
15Synaptic vesicle cycle_Homo sapiens_hsa047211.51261765
16Gastric acid secretion_Homo sapiens_hsa049711.51246434
17Dopaminergic synapse_Homo sapiens_hsa047281.47042333
18Cholinergic synapse_Homo sapiens_hsa047251.46875392
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.45422410
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.43594988
21Oxytocin signaling pathway_Homo sapiens_hsa049211.42874363
22Calcium signaling pathway_Homo sapiens_hsa040201.42542523
23Renin secretion_Homo sapiens_hsa049241.42436409
24Hepatitis B_Homo sapiens_hsa051611.37973655
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37220794
26Insulin secretion_Homo sapiens_hsa049111.35978042
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35467732
28Graft-versus-host disease_Homo sapiens_hsa053321.34959513
29Autoimmune thyroid disease_Homo sapiens_hsa053201.33760667
30Allograft rejection_Homo sapiens_hsa053301.33655562
31Long-term depression_Homo sapiens_hsa047301.28811633
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27109563
33Influenza A_Homo sapiens_hsa051641.27037722
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26712537
35Toxoplasmosis_Homo sapiens_hsa051451.26374720
36cAMP signaling pathway_Homo sapiens_hsa040241.25408406
37GnRH signaling pathway_Homo sapiens_hsa049121.24838929
38Herpes simplex infection_Homo sapiens_hsa051681.24358367
39Taste transduction_Homo sapiens_hsa047421.24120550
40Type II diabetes mellitus_Homo sapiens_hsa049301.22314797
41Primary immunodeficiency_Homo sapiens_hsa053401.22240640
42FoxO signaling pathway_Homo sapiens_hsa040681.19729627
43Other glycan degradation_Homo sapiens_hsa005111.19424229
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19031609
45Cocaine addiction_Homo sapiens_hsa050301.18877263
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17630796
47Type I diabetes mellitus_Homo sapiens_hsa049401.17311240
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16589951
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15367433
50Prostate cancer_Homo sapiens_hsa052151.14398347
51ErbB signaling pathway_Homo sapiens_hsa040121.13699485
52Glioma_Homo sapiens_hsa052141.12038522
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11280844
54Hepatitis C_Homo sapiens_hsa051601.09113384
55T cell receptor signaling pathway_Homo sapiens_hsa046601.08271069
56B cell receptor signaling pathway_Homo sapiens_hsa046621.07089813
57mTOR signaling pathway_Homo sapiens_hsa041501.06970755
58TNF signaling pathway_Homo sapiens_hsa046681.06184214
59Tuberculosis_Homo sapiens_hsa051521.04058972
60Serotonergic synapse_Homo sapiens_hsa047261.02720379
61Axon guidance_Homo sapiens_hsa043601.02689803
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00063806
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.99494288
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99212551
65Lysine degradation_Homo sapiens_hsa003100.99172375
66Dorso-ventral axis formation_Homo sapiens_hsa043200.98689139
67Non-small cell lung cancer_Homo sapiens_hsa052230.97810779
68Inositol phosphate metabolism_Homo sapiens_hsa005620.97593872
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.96871870
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.96627730
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.96080854
72Thyroid cancer_Homo sapiens_hsa052160.95657894
73Gap junction_Homo sapiens_hsa045400.95245654
74Endometrial cancer_Homo sapiens_hsa052130.94931421
75Colorectal cancer_Homo sapiens_hsa052100.94554918
76Choline metabolism in cancer_Homo sapiens_hsa052310.94514153
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93276518
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92661687
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92497721
80Hematopoietic cell lineage_Homo sapiens_hsa046400.92248024
81* Insulin resistance_Homo sapiens_hsa049310.91604549
82Estrogen signaling pathway_Homo sapiens_hsa049150.90184074
83Circadian rhythm_Homo sapiens_hsa047100.90047770
84Melanogenesis_Homo sapiens_hsa049160.89562775
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89559816
86MAPK signaling pathway_Homo sapiens_hsa040100.88618621
87Notch signaling pathway_Homo sapiens_hsa043300.87654025
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87503933
89Staphylococcus aureus infection_Homo sapiens_hsa051500.85657122
90Chronic myeloid leukemia_Homo sapiens_hsa052200.85356350
91Viral myocarditis_Homo sapiens_hsa054160.85209842
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84622866
93Dilated cardiomyopathy_Homo sapiens_hsa054140.82314712
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81904415
95Small cell lung cancer_Homo sapiens_hsa052220.81018054
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80746756
97Antigen processing and presentation_Homo sapiens_hsa046120.80600160
98Pancreatic secretion_Homo sapiens_hsa049720.80235013
99* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80206630
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80165099
101Rap1 signaling pathway_Homo sapiens_hsa040150.78745192
102Viral carcinogenesis_Homo sapiens_hsa052030.78243892
103HTLV-I infection_Homo sapiens_hsa051660.77936526
104Platelet activation_Homo sapiens_hsa046110.77133392
105mRNA surveillance pathway_Homo sapiens_hsa030150.76412578
106Chemokine signaling pathway_Homo sapiens_hsa040620.75908181
107Wnt signaling pathway_Homo sapiens_hsa043100.75710943
108Apoptosis_Homo sapiens_hsa042100.73511305
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73349923
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.72662778
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70993451
112HIF-1 signaling pathway_Homo sapiens_hsa040660.67958067
113Basal cell carcinoma_Homo sapiens_hsa052170.66395405
114VEGF signaling pathway_Homo sapiens_hsa043700.66212334
115Pancreatic cancer_Homo sapiens_hsa052120.64932714
116Proteoglycans in cancer_Homo sapiens_hsa052050.64334690
117ABC transporters_Homo sapiens_hsa020100.64132709
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63046710
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.62454082
120Acute myeloid leukemia_Homo sapiens_hsa052210.60933003
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60105607
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60074384
123Osteoclast differentiation_Homo sapiens_hsa043800.59407733
124Insulin signaling pathway_Homo sapiens_hsa049100.59083384
125Renal cell carcinoma_Homo sapiens_hsa052110.58965204
126Ras signaling pathway_Homo sapiens_hsa040140.58306306
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58086341
128Thyroid hormone synthesis_Homo sapiens_hsa049180.57627997
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.56542696
130Asthma_Homo sapiens_hsa053100.55967822
131Epstein-Barr virus infection_Homo sapiens_hsa051690.55816296
132Prolactin signaling pathway_Homo sapiens_hsa049170.55480679
133Adherens junction_Homo sapiens_hsa045200.55382812
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55273584
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54548232
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.54065482
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.53813036
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52650293
139Glucagon signaling pathway_Homo sapiens_hsa049220.52369748
140Fatty acid biosynthesis_Homo sapiens_hsa000610.51351244
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50572070
142MicroRNAs in cancer_Homo sapiens_hsa052060.50367951
143Phototransduction_Homo sapiens_hsa047440.49942193
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49242401
145AMPK signaling pathway_Homo sapiens_hsa041520.42871026

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