OIP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1telomere maintenance via semi-conservative replication (GO:0032201)5.15922485
2DNA strand elongation involved in DNA replication (GO:0006271)5.12108605
3kinetochore organization (GO:0051383)4.88496461
4DNA strand elongation (GO:0022616)4.87034202
5DNA replication initiation (GO:0006270)4.78450255
6* CENP-A containing nucleosome assembly (GO:0034080)4.73557752
7telomere maintenance via recombination (GO:0000722)4.71904887
8mitotic metaphase plate congression (GO:0007080)4.70907823
9* chromatin remodeling at centromere (GO:0031055)4.66266772
10DNA replication checkpoint (GO:0000076)4.65281495
11protein localization to kinetochore (GO:0034501)4.59396851
12kinetochore assembly (GO:0051382)4.57028514
13ribosomal small subunit assembly (GO:0000028)4.56671139
14mitotic recombination (GO:0006312)4.51275899
15DNA deamination (GO:0045006)4.46409881
16DNA ligation (GO:0006266)4.33139654
17* DNA replication-independent nucleosome organization (GO:0034724)4.16230083
18* DNA replication-independent nucleosome assembly (GO:0006336)4.16230083
19metaphase plate congression (GO:0051310)4.14560019
20establishment of integrated proviral latency (GO:0075713)4.14280940
21protein localization to chromosome, centromeric region (GO:0071459)4.13030143
22attachment of spindle microtubules to kinetochore (GO:0008608)4.12204676
23telomere maintenance via telomere lengthening (GO:0010833)4.09740939
24DNA unwinding involved in DNA replication (GO:0006268)3.99971186
25mitotic sister chromatid segregation (GO:0000070)3.98465777
26nucleotide-excision repair, DNA gap filling (GO:0006297)3.96828729
27folic acid-containing compound biosynthetic process (GO:0009396)3.96481777
28regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.95715335
29maturation of SSU-rRNA (GO:0030490)3.87581971
30nucleobase biosynthetic process (GO:0046112)3.85730835
31mitotic nuclear envelope disassembly (GO:0007077)3.84931274
32* histone exchange (GO:0043486)3.83119751
33L-serine metabolic process (GO:0006563)3.77700000
34purine nucleobase biosynthetic process (GO:0009113)3.77679079
35establishment of chromosome localization (GO:0051303)3.77223522
36DNA replication-dependent nucleosome organization (GO:0034723)3.71265183
37DNA replication-dependent nucleosome assembly (GO:0006335)3.71265183
38IMP biosynthetic process (GO:0006188)3.68905538
39meiotic chromosome segregation (GO:0045132)3.64996285
40mitotic chromosome condensation (GO:0007076)3.63688723
41nuclear pore organization (GO:0006999)3.61818656
42sister chromatid segregation (GO:0000819)3.58310279
43regulation of double-strand break repair via homologous recombination (GO:0010569)3.57840792
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.56541996
45regulation of nuclear cell cycle DNA replication (GO:0033262)3.54822253
46proteasome assembly (GO:0043248)3.54345434
47chromosome condensation (GO:0030261)3.53363747
48membrane disassembly (GO:0030397)3.53171294
49nuclear envelope disassembly (GO:0051081)3.53171294
50ribosome biogenesis (GO:0042254)3.52530798
51chaperone-mediated protein transport (GO:0072321)3.51854013
52formation of translation preinitiation complex (GO:0001731)3.50396949
53RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.48138336
54tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.48138336
55protein K6-linked ubiquitination (GO:0085020)3.47701286
56regulation of spindle organization (GO:0090224)3.46359404
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.42563156
58ribonucleoprotein complex biogenesis (GO:0022613)3.41033399
59ribosomal large subunit biogenesis (GO:0042273)3.40803932
60DNA topological change (GO:0006265)3.34212467
61nuclear pore complex assembly (GO:0051292)3.33951114
62transcription-coupled nucleotide-excision repair (GO:0006283)3.33280213
63spindle checkpoint (GO:0031577)3.31149551
64spliceosomal snRNP assembly (GO:0000387)3.29808104
65mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.26778717
66viral transcription (GO:0019083)3.26605101
67ribosomal small subunit biogenesis (GO:0042274)3.24551540
68deoxyribonucleotide biosynthetic process (GO:0009263)3.23108806
69negative regulation of chromosome segregation (GO:0051985)3.22584938
70telomere maintenance (GO:0000723)3.22523765
71telomere organization (GO:0032200)3.22241600
72translational termination (GO:0006415)3.22053124
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.21895552
74negative regulation of sister chromatid segregation (GO:0033046)3.21895552
75negative regulation of mitotic sister chromatid separation (GO:2000816)3.21895552
76negative regulation of mitotic sister chromatid segregation (GO:0033048)3.21895552
77establishment of viral latency (GO:0019043)3.21724059
78spindle assembly checkpoint (GO:0071173)3.19721980
79negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.18123752
80negative regulation of ligase activity (GO:0051352)3.18123752
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17802027
82maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.17722118
83ribosome assembly (GO:0042255)3.17461920
84rRNA modification (GO:0000154)3.17129777
85negative regulation of mitosis (GO:0045839)3.15866804
86IMP metabolic process (GO:0046040)3.15369279
87positive regulation of chromosome segregation (GO:0051984)3.15096578
88rRNA processing (GO:0006364)3.14709585
89regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14457257
90chromosome segregation (GO:0007059)3.14254833
91mitochondrial RNA metabolic process (GO:0000959)3.13325813
92regulation of mitotic spindle organization (GO:0060236)3.13055709
93viral mRNA export from host cell nucleus (GO:0046784)3.12408080
94pseudouridine synthesis (GO:0001522)3.12296309
95negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12094878
96* ATP-dependent chromatin remodeling (GO:0043044)3.11556313
97DNA packaging (GO:0006323)3.10990055
98regulation of chromosome segregation (GO:0051983)3.10957752
99mitotic spindle assembly checkpoint (GO:0007094)3.10841008
100mitotic G2/M transition checkpoint (GO:0044818)3.10080212
101regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09203955
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.07265194
103regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.07053061
104pteridine-containing compound biosynthetic process (GO:0042559)3.06888974
105regulation of centrosome cycle (GO:0046605)3.06144585
106rRNA metabolic process (GO:0016072)3.06002111
107cell cycle G1/S phase transition (GO:0044843)3.05112042
108G1/S transition of mitotic cell cycle (GO:0000082)3.05112042
109negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04220000
110protein complex localization (GO:0031503)3.02230501
111protein localization to chromosome (GO:0034502)3.01583131
112regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01504030
113regulation of mitotic spindle checkpoint (GO:1903504)3.01504030
114regulation of mitochondrial translation (GO:0070129)3.01498676
115* chromatin assembly or disassembly (GO:0006333)3.01414031
116regulation of mitotic sister chromatid separation (GO:0010965)3.00507513
117regulation of mitotic sister chromatid segregation (GO:0033047)3.00507513
118regulation of sister chromatid segregation (GO:0033045)3.00507513
119mitotic spindle checkpoint (GO:0071174)3.00265914
120mismatch repair (GO:0006298)3.00074417
121spliceosomal complex assembly (GO:0000245)2.99651625
122translational elongation (GO:0006414)2.99557083
123pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.98018887
124mitotic cell cycle (GO:0000278)2.97633210
125pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.97119363
126microtubule depolymerization (GO:0007019)2.96823820
127translational initiation (GO:0006413)2.96436896
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.95892771
129exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91839167
130DNA double-strand break processing (GO:0000729)2.90664413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.23225711
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.72594933
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.17143848
4* MYC_18555785_ChIP-Seq_MESCs_Mouse4.15975748
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.60672844
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51340224
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48884553
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.11890464
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88485708
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88225229
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.83540700
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82580002
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80691362
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.73205645
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65969580
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49318633
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36540124
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36245332
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32803697
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30367719
21VDR_23849224_ChIP-Seq_CD4+_Human2.25798369
22XRN2_22483619_ChIP-Seq_HELA_Human2.25786594
23AR_21909140_ChIP-Seq_LNCAP_Human2.18095138
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14889760
25* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.14872082
26* E2F1_21310950_ChIP-Seq_MCF-7_Human2.10708574
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02563129
28DCP1A_22483619_ChIP-Seq_HELA_Human2.01303166
29FOXP3_21729870_ChIP-Seq_TREG_Human2.01106548
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00453699
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95190054
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92081290
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85970023
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85216776
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80032325
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79865491
37TTF2_22483619_ChIP-Seq_HELA_Human1.79257290
38GABP_19822575_ChIP-Seq_HepG2_Human1.79228235
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77447332
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70725644
41ELK1_19687146_ChIP-ChIP_HELA_Human1.70510800
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70465407
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.68519250
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66078026
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.60281330
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58532709
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55917832
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55713111
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54435069
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.51218834
51CIITA_25753668_ChIP-Seq_RAJI_Human1.49584146
52* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46959729
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46271642
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39896897
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33383898
56KDM5A_27292631_Chip-Seq_BREAST_Human1.32344732
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29207981
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28385856
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28303308
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.26798203
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21827966
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20972694
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20326995
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19768544
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18446542
66* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18116163
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17454652
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17194319
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12628606
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11175506
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10953384
72MYC_22102868_ChIP-Seq_BL_Human1.10893342
73* NANOG_16153702_ChIP-ChIP_HESCs_Human1.05106759
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03683807
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03415765
76* SOX2_16153702_ChIP-ChIP_HESCs_Human1.03209272
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01896628
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.01879896
79TFEB_21752829_ChIP-Seq_HELA_Human1.00809896
80MYC_18940864_ChIP-ChIP_HL60_Human1.00406768
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99939659
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99115108
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96424105
84RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95059513
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94792933
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93713833
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93298761
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91913401
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90495934
90SPI1_23547873_ChIP-Seq_NB4_Human0.89278103
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83325431
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83037714
93SALL1_21062744_ChIP-ChIP_HESCs_Human0.82859553
94ZNF263_19887448_ChIP-Seq_K562_Human0.82602841
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79761026
96* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78932380
97EWS_26573619_Chip-Seq_HEK293_Human0.78840344
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77295199
99* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76051520
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.73552134
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73089289
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.72654688
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71954004
104TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71889962
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.71691684
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71636285
107* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.71566648
108NANOG_21062744_ChIP-ChIP_HESCs_Human0.71065136
109TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70190584
110IRF1_19129219_ChIP-ChIP_H3396_Human0.70156741
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.68912152
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.67845206
113VDR_21846776_ChIP-Seq_THP-1_Human0.67164607
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.67007986
115* SOX17_20123909_ChIP-Seq_XEN_Mouse0.66101711
116FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65825188
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.65424775
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.65421320
119TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.64512091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.07923241
2MP0010094_abnormal_chromosome_stability5.10226433
3MP0003111_abnormal_nucleus_morphology4.95717893
4MP0004957_abnormal_blastocyst_morpholog4.49771729
5MP0008057_abnormal_DNA_replication4.35949563
6MP0003077_abnormal_cell_cycle4.25134699
7MP0008058_abnormal_DNA_repair3.74895794
8MP0008007_abnormal_cellular_replicative3.19170743
9MP0008932_abnormal_embryonic_tissue2.73482989
10MP0002396_abnormal_hematopoietic_system2.45735346
11MP0003786_premature_aging2.35475004
12MP0003123_paternal_imprinting2.29302335
13MP0000350_abnormal_cell_proliferation2.13838739
14MP0001730_embryonic_growth_arrest2.05780690
15MP0008877_abnormal_DNA_methylation2.04486423
16MP0003718_maternal_effect1.83057698
17MP0000490_abnormal_crypts_of1.77374712
18MP0010307_abnormal_tumor_latency1.74336180
19MP0010352_gastrointestinal_tract_polyps1.71774892
20MP0006292_abnormal_olfactory_placode1.62108208
21MP0001545_abnormal_hematopoietic_system1.58892926
22MP0005397_hematopoietic_system_phenotyp1.58892926
23MP0001697_abnormal_embryo_size1.56270912
24MP0000313_abnormal_cell_death1.56112972
25MP0008995_early_reproductive_senescence1.50500176
26MP0004808_abnormal_hematopoietic_stem1.50488675
27MP0001672_abnormal_embryogenesis/_devel1.49271610
28MP0005380_embryogenesis_phenotype1.49271610
29MP0002019_abnormal_tumor_incidence1.45479252
30MP0009333_abnormal_splenocyte_physiolog1.42551241
31MP0002080_prenatal_lethality1.42282209
32MP0003315_abnormal_perineum_morphology1.38723051
33MP0002132_abnormal_respiratory_system1.37410795
34MP0002210_abnormal_sex_determination1.35771477
35MP0003937_abnormal_limbs/digits/tail_de1.34217050
36MP0002085_abnormal_embryonic_tissue1.29184519
37MP0003806_abnormal_nucleotide_metabolis1.26704591
38MP0003984_embryonic_growth_retardation1.26590699
39MP0003567_abnormal_fetal_cardiomyocyte1.26507653
40MP0009672_abnormal_birth_weight1.22741986
41MP0002088_abnormal_embryonic_growth/wei1.22265114
42MP0002086_abnormal_extraembryonic_tissu1.20600694
43MP0008789_abnormal_olfactory_epithelium1.20289491
44MP0004147_increased_porphyrin_level1.19985608
45MP0003186_abnormal_redox_activity1.18845391
46MP0001661_extended_life_span1.16819950
47MP0003121_genomic_imprinting1.16762137
48MP0000372_irregular_coat_pigmentation1.15392742
49MP0001145_abnormal_male_reproductive1.15123184
50MP0002398_abnormal_bone_marrow1.14922755
51MP0003763_abnormal_thymus_physiology1.14798418
52MP0004197_abnormal_fetal_growth/weight/1.13602868
53MP0002697_abnormal_eye_size1.13216339
54MP0002736_abnormal_nociception_after1.10253427
55MP0000703_abnormal_thymus_morphology1.07457302
56MP0001929_abnormal_gametogenesis1.06365468
57MP0002084_abnormal_developmental_patter1.06316189
58MP0003941_abnormal_skin_development1.06250832
59MP0009379_abnormal_foot_pigmentation1.05781869
60MP0002722_abnormal_immune_system1.05019256
61MP0010030_abnormal_orbit_morphology1.04775123
62MP0003656_abnormal_erythrocyte_physiolo1.04603776
63MP0001293_anophthalmia1.04403769
64MP0002160_abnormal_reproductive_system1.03349338
65MP0000049_abnormal_middle_ear1.02999723
66MP0000689_abnormal_spleen_morphology1.02345770
67MP0001529_abnormal_vocalization1.01100577
68MP0003890_abnormal_embryonic-extraembry1.00682320
69MP0001764_abnormal_homeostasis1.00653389
70MP0005075_abnormal_melanosome_morpholog0.99354620
71MP0000653_abnormal_sex_gland0.98625124
72MP0001119_abnormal_female_reproductive0.96577526
73MP0006072_abnormal_retinal_apoptosis0.95716050
74MP0005174_abnormal_tail_pigmentation0.94747727
75MP0002095_abnormal_skin_pigmentation0.93285427
76MP0005389_reproductive_system_phenotype0.92442165
77MP0002233_abnormal_nose_morphology0.91506735
78MP0000858_altered_metastatic_potential0.90438968
79MP0002429_abnormal_blood_cell0.89656744
80MP0000015_abnormal_ear_pigmentation0.87247883
81MP0005670_abnormal_white_adipose0.84889335
82MP0006054_spinal_hemorrhage0.82363968
83MP0005499_abnormal_olfactory_system0.81535896
84MP0005394_taste/olfaction_phenotype0.81535896
85MP0005360_urolithiasis0.81063592
86MP0001853_heart_inflammation0.80370676
87MP0006036_abnormal_mitochondrial_physio0.79228505
88MP0002938_white_spotting0.77969249
89MP0000631_abnormal_neuroendocrine_gland0.77273361
90MP0002161_abnormal_fertility/fecundity0.76942318
91MP0005646_abnormal_pituitary_gland0.75353741
92MP0004185_abnormal_adipocyte_glucose0.75026764
93MP0000358_abnormal_cell_content/0.74609378
94MP0005384_cellular_phenotype0.74198797
95MP0000647_abnormal_sebaceous_gland0.74161263
96MP0000716_abnormal_immune_system0.73857463
97MP0000537_abnormal_urethra_morphology0.73515747
98MP0005395_other_phenotype0.72221538
99MP0002234_abnormal_pharynx_morphology0.71297153
100MP0001835_abnormal_antigen_presentation0.70258734
101MP0001919_abnormal_reproductive_system0.68965978
102MP0004133_heterotaxia0.68458165
103MP0005621_abnormal_cell_physiology0.66525589
104MP0002102_abnormal_ear_morphology0.65893956
105MP0009703_decreased_birth_body0.64962351
106MP0002111_abnormal_tail_morphology0.64359429
107MP0006035_abnormal_mitochondrial_morpho0.64159307
108MP0002075_abnormal_coat/hair_pigmentati0.63821617
109MP0003755_abnormal_palate_morphology0.61663768
110MP0001186_pigmentation_phenotype0.61269959
111MP0009697_abnormal_copulation0.61140843
112MP0000579_abnormal_nail_morphology0.61027078
113MP0005391_vision/eye_phenotype0.60462161
114MP0005501_abnormal_skin_physiology0.58054869
115MP0005266_abnormal_metabolism0.57312147
116MP0002092_abnormal_eye_morphology0.56880010
117MP0001286_abnormal_eye_development0.56478920
118MP0000566_synostosis0.55769621
119MP0002420_abnormal_adaptive_immunity0.55155454
120MP0003861_abnormal_nervous_system0.55007730
121MP0003698_abnormal_male_reproductive0.54864480
122MP0001819_abnormal_immune_cell0.54523328
123MP0001188_hyperpigmentation0.54467742
124MP0001800_abnormal_humoral_immune0.54414168
125MP0000762_abnormal_tongue_morphology0.53993761
126MP0005671_abnormal_response_to0.53977302
127MP0005076_abnormal_cell_differentiation0.53960011
128MP0005253_abnormal_eye_physiology0.53796449
129MP0009785_altered_susceptibility_to0.53196146
130MP0002452_abnormal_antigen_presenting0.53159397
131MP0003136_yellow_coat_color0.53098848
132MP0000428_abnormal_craniofacial_morphol0.52936647
133MP0000477_abnormal_intestine_morphology0.52643908
134MP0001986_abnormal_taste_sensitivity0.51262076
135MP0003119_abnormal_digestive_system0.49513268
136MP0003699_abnormal_female_reproductive0.49118794

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.95001492
2Chromsome breakage (HP:0040012)5.03424121
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.92792037
4Reticulocytopenia (HP:0001896)4.57992535
5Abnormal number of erythroid precursors (HP:0012131)4.36230449
6Abnormality of cells of the erythroid lineage (HP:0012130)4.34648751
7Breast hypoplasia (HP:0003187)4.32818808
8Abnormality of alanine metabolism (HP:0010916)3.92693438
9Hyperalaninemia (HP:0003348)3.92693438
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.92693438
11Meckel diverticulum (HP:0002245)3.74641571
12Abnormality of the preputium (HP:0100587)3.67714044
13Abnormality of chromosome stability (HP:0003220)3.60879599
14Abnormality of the ileum (HP:0001549)3.58633120
15Patellar aplasia (HP:0006443)3.57345887
16Oral leukoplakia (HP:0002745)3.49183593
17Acute necrotizing encephalopathy (HP:0006965)3.47794006
18Carpal bone hypoplasia (HP:0001498)3.45356380
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.35590794
20Aplasia/Hypoplasia of the patella (HP:0006498)3.35154437
21Aplastic anemia (HP:0001915)3.26677280
22Abnormal mitochondria in muscle tissue (HP:0008316)3.25795604
23Absent thumb (HP:0009777)3.25549229
24Acute encephalopathy (HP:0006846)3.24256061
25Myelodysplasia (HP:0002863)3.11042855
26Small intestinal stenosis (HP:0012848)3.06881818
27Duodenal stenosis (HP:0100867)3.06881818
28Abnormality of the heme biosynthetic pathway (HP:0010472)3.03142620
29Selective tooth agenesis (HP:0001592)2.98893961
30Absent radius (HP:0003974)2.94188527
31Impulsivity (HP:0100710)2.92297692
32Bone marrow hypocellularity (HP:0005528)2.92177352
33Rough bone trabeculation (HP:0100670)2.89469077
34Colon cancer (HP:0003003)2.88294627
35Duplicated collecting system (HP:0000081)2.87524881
36Pallor (HP:0000980)2.80354902
37Mitochondrial inheritance (HP:0001427)2.79906386
38Degeneration of anterior horn cells (HP:0002398)2.79684537
39Abnormality of the anterior horn cell (HP:0006802)2.79684537
40Increased serum pyruvate (HP:0003542)2.79656841
41Increased CSF lactate (HP:0002490)2.79000241
42Absent forearm bone (HP:0003953)2.74143069
43Aplasia involving forearm bones (HP:0009822)2.74143069
44Ectopic kidney (HP:0000086)2.72105657
45Macrocytic anemia (HP:0001972)2.71458623
46Abnormality of serum amino acid levels (HP:0003112)2.69007913
47Progressive macrocephaly (HP:0004481)2.68894160
48Microretrognathia (HP:0000308)2.64300194
4911 pairs of ribs (HP:0000878)2.60053596
50Premature graying of hair (HP:0002216)2.58760276
51Abnormality of the renal collecting system (HP:0004742)2.58568100
52Abnormal lung lobation (HP:0002101)2.57459204
53Abnormality of glycolysis (HP:0004366)2.56698316
54Abnormal umbilical cord blood vessels (HP:0011403)2.55636441
55Single umbilical artery (HP:0001195)2.55636441
56Abnormality of the fetal cardiovascular system (HP:0010948)2.55636441
57Cerebral edema (HP:0002181)2.55009350
58Abnormality of the duodenum (HP:0002246)2.51083267
59Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.49339335
60Hyperglycinemia (HP:0002154)2.49281020
61Hepatocellular necrosis (HP:0001404)2.46242109
62Sloping forehead (HP:0000340)2.45536367
63Triphalangeal thumb (HP:0001199)2.45075316
64Medulloblastoma (HP:0002885)2.44718906
65Horseshoe kidney (HP:0000085)2.42881449
66Aplasia/Hypoplasia of the sacrum (HP:0008517)2.42655042
67Agnosia (HP:0010524)2.40957296
68Abnormality of the labia minora (HP:0012880)2.38924071
69Clubbing of toes (HP:0100760)2.34589183
70Nephroblastoma (Wilms tumor) (HP:0002667)2.29965162
71Tracheoesophageal fistula (HP:0002575)2.29346676
72Supernumerary spleens (HP:0009799)2.29198703
73Lactic acidosis (HP:0003128)2.29157253
74Pancytopenia (HP:0001876)2.28229717
75Abnormality of the carotid arteries (HP:0005344)2.27154494
76Lipid accumulation in hepatocytes (HP:0006561)2.24328697
77Homocystinuria (HP:0002156)2.23651659
78Abnormality of homocysteine metabolism (HP:0010919)2.23651659
79Type I transferrin isoform profile (HP:0003642)2.22051764
80Short thumb (HP:0009778)2.21847846
81Cleft eyelid (HP:0000625)2.21286711
82Cerebral hypomyelination (HP:0006808)2.18586805
83Thrombocytosis (HP:0001894)2.18110301
84Hepatic necrosis (HP:0002605)2.17013662
85Embryonal renal neoplasm (HP:0011794)2.16962903
86Duplication of thumb phalanx (HP:0009942)2.14507218
87Abnormal trabecular bone morphology (HP:0100671)2.14327773
88Neoplasm of the pancreas (HP:0002894)2.14264501
89Cellular immunodeficiency (HP:0005374)2.12946617
90Microvesicular hepatic steatosis (HP:0001414)2.11804395
91Multiple enchondromatosis (HP:0005701)2.09788424
92Septo-optic dysplasia (HP:0100842)2.09748399
93Abnormal number of incisors (HP:0011064)2.09221076
94Abnormality of reticulocytes (HP:0004312)2.08153755
95Maternal diabetes (HP:0009800)2.07657179
96Hypoplastic pelvis (HP:0008839)2.06179046
97Megaloblastic anemia (HP:0001889)2.05801673
98Exercise intolerance (HP:0003546)2.05128435
99Abnormality of the umbilical cord (HP:0010881)2.04529364
100Absent septum pellucidum (HP:0001331)2.04471977
101Cortical dysplasia (HP:0002539)2.03599584
102Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02578572
103Abnormality of DNA repair (HP:0003254)2.01713939
104Abnormality of cochlea (HP:0000375)2.01292233
105Abnormality of methionine metabolism (HP:0010901)1.99714213
106Arteriovenous malformation (HP:0100026)1.98275207
107Slender long bone (HP:0003100)1.97587427
108Petechiae (HP:0000967)1.96820963
109Stenosis of the external auditory canal (HP:0000402)1.95648285
110Lymphoma (HP:0002665)1.95537392
111Atresia of the external auditory canal (HP:0000413)1.93887473
112Ependymoma (HP:0002888)1.93886023
113Aplasia/Hypoplasia of the sternum (HP:0006714)1.91929847
114Optic nerve coloboma (HP:0000588)1.90647994
115Abnormality of sulfur amino acid metabolism (HP:0004339)1.89991541
116Abnormality of pyrimidine metabolism (HP:0004353)1.89302686
117Abnormal spermatogenesis (HP:0008669)1.87893542
118Cafe-au-lait spot (HP:0000957)1.86879804
119Abnormality of the septum pellucidum (HP:0007375)1.84430225
120Constricted visual fields (HP:0001133)1.83220937
121Methylmalonic acidemia (HP:0002912)1.81447907
122Squamous cell carcinoma (HP:0002860)1.81446044
123Increased nuchal translucency (HP:0010880)1.81437649
124Rhabdomyosarcoma (HP:0002859)1.81233318
125Pendular nystagmus (HP:0012043)1.80253879
126Leukodystrophy (HP:0002415)1.79778610
127Increased serum lactate (HP:0002151)1.78925445
128Reduced antithrombin III activity (HP:0001976)1.78667240
129Hypoplasia of the radius (HP:0002984)1.77821995
130Progressive muscle weakness (HP:0003323)1.76074377
131Amaurosis fugax (HP:0100576)1.75151213
132Asplenia (HP:0001746)1.74762929
133Trismus (HP:0000211)1.73867257
134Poor head control (HP:0002421)1.73210590
135Renal Fanconi syndrome (HP:0001994)1.72036750
136Respiratory failure (HP:0002878)1.71664489
137Increased intramyocellular lipid droplets (HP:0012240)1.71483287
138Short middle phalanx of the 5th finger (HP:0004220)1.70151340
139Muscle fiber atrophy (HP:0100295)1.69436459
140Hypopigmented skin patches (HP:0001053)1.69147382
141Rectovaginal fistula (HP:0000143)1.67043510
142Rectal fistula (HP:0100590)1.67043510
143Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.66988616
144Decreased activity of mitochondrial respiratory chain (HP:0008972)1.66988616
145Neoplasm of the colon (HP:0100273)1.66323352
146Increased hepatocellular lipid droplets (HP:0006565)1.64991966
147Basal cell carcinoma (HP:0002671)1.64777668
148Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.63773738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.23241133
2WEE14.35725881
3CDC73.94002448
4VRK23.38369499
5EIF2AK13.04657062
6SRPK12.91882841
7NEK22.87860056
8BRSK22.87469084
9PLK42.71270267
10STK162.65940985
11TTK2.50992394
12VRK12.24638813
13PLK12.21506257
14ACVR1B2.12340820
15NEK12.11605878
16NME22.04265039
17CCNB11.96174353
18BRSK11.95980392
19MKNK11.95344446
20EIF2AK31.85055063
21AURKB1.82025089
22ZAK1.74102937
23ATR1.69484588
24CHEK21.67559619
25PLK31.64539496
26TLK11.63097971
27TSSK61.62835066
28MKNK21.61420563
29CDK71.56725435
30PASK1.46753512
31TAF11.40972756
32DYRK31.36051030
33RPS6KB21.32184479
34STK41.31694600
35AURKA1.29711829
36TRIM281.28550461
37EPHA21.26237083
38CDK41.23867114
39PBK1.20706890
40RPS6KA41.20394484
41CHEK11.17298007
42EIF2AK21.14359323
43CDK121.13455543
44PDK21.12808584
45CDK81.10991070
46MAP3K81.08630163
47PIM21.06734424
48SCYL21.06408416
49TESK21.01819647
50BRD40.99274506
51STK100.96708464
52PNCK0.96420184
53BCKDK0.93134237
54BRAF0.92312420
55PIM10.86188064
56IRAK30.85880417
57ATM0.85364845
58PAK40.84246180
59CDK90.80983001
60BMPR1B0.78545972
61CDK20.76929689
62MELK0.76283006
63WNK30.76059151
64TGFBR10.74835128
65CDK190.73914182
66CSNK2A10.71092773
67TNIK0.65735643
68IRAK40.65370575
69CSNK2A20.62826688
70CDK10.62655362
71CLK10.60250095
72PAK10.55764631
73PRKCI0.55481067
74EEF2K0.54970110
75MAP3K100.54847143
76CDK60.52296683
77AKT30.52014102
78TEC0.51193231
79FLT30.50338016
80MAP4K10.49469549
81RPS6KA50.48384658
82SMG10.47205111
83KDR0.46868410
84CSNK1G10.45438234
85YES10.45362717
86MAP3K110.44123093
87TESK10.41934022
88DYRK20.41501446
89UHMK10.40562694
90ERBB40.40371181
91ALK0.40092172
92CSNK1G30.38263907
93NEK90.37866865
94STK38L0.35449557
95STK30.34912360
96PLK20.32947260
97JAK30.32921255
98NME10.32679580
99MAP4K20.31159351
100CSNK1E0.30497046
101CDK30.28638730
102MAPKAPK30.28543395
103CDK11A0.28451634
104TAOK20.28080702
105FGR0.27282212
106CDK180.27097940
107AKT20.27002005
108CDK150.26505302
109CSNK1G20.25948692
110BTK0.25819825
111CDK140.25812188
112IKBKB0.24493288
113PRKDC0.24308638
114DAPK10.22699255
115MARK30.22670913
116LYN0.21765575
117TXK0.20685066
118CSNK1A10.20665291
119MST1R0.20039564
120ARAF0.19728071
121ABL20.18076004
122BCR0.18046890
123MAPK140.17925149
124MAPK110.16960136
125ERBB30.16927334
126EPHB20.16699558
127LRRK20.15818014
128AKT10.14787325
129MAP2K30.13727938
130NUAK10.12867513
131TYK20.11792281
132MST40.09857857

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.38151259
2Mismatch repair_Homo sapiens_hsa034304.60305424
3Homologous recombination_Homo sapiens_hsa034403.52348884
4Ribosome_Homo sapiens_hsa030103.46594697
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.45594062
6Base excision repair_Homo sapiens_hsa034103.32637860
7Proteasome_Homo sapiens_hsa030503.20970805
8Spliceosome_Homo sapiens_hsa030403.20637043
9RNA polymerase_Homo sapiens_hsa030203.14971731
10Nucleotide excision repair_Homo sapiens_hsa034203.01519801
11RNA transport_Homo sapiens_hsa030132.85211295
12Cell cycle_Homo sapiens_hsa041102.81346944
13Fanconi anemia pathway_Homo sapiens_hsa034602.69497104
14Pyrimidine metabolism_Homo sapiens_hsa002402.67623597
15One carbon pool by folate_Homo sapiens_hsa006702.49065196
16Non-homologous end-joining_Homo sapiens_hsa034502.23082996
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21782402
18Basal transcription factors_Homo sapiens_hsa030221.95863764
19RNA degradation_Homo sapiens_hsa030181.92452163
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71827914
21p53 signaling pathway_Homo sapiens_hsa041151.69706356
22mRNA surveillance pathway_Homo sapiens_hsa030151.50066350
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47639752
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46472848
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45199341
26Purine metabolism_Homo sapiens_hsa002301.44697077
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39690356
28Pyruvate metabolism_Homo sapiens_hsa006201.30618627
29Systemic lupus erythematosus_Homo sapiens_hsa053221.27747846
30Fatty acid elongation_Homo sapiens_hsa000621.12896621
31Epstein-Barr virus infection_Homo sapiens_hsa051691.08247892
32Steroid biosynthesis_Homo sapiens_hsa001001.06885601
33Herpes simplex infection_Homo sapiens_hsa051681.02032434
34Propanoate metabolism_Homo sapiens_hsa006401.01871581
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94989606
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89658879
37Oocyte meiosis_Homo sapiens_hsa041140.86054974
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83204758
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80034588
40Drug metabolism - other enzymes_Homo sapiens_hsa009830.78364799
41Viral carcinogenesis_Homo sapiens_hsa052030.77858033
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76239465
43Protein export_Homo sapiens_hsa030600.74899527
44Huntingtons disease_Homo sapiens_hsa050160.74880507
45Pentose phosphate pathway_Homo sapiens_hsa000300.73853747
46Folate biosynthesis_Homo sapiens_hsa007900.73153164
47Antigen processing and presentation_Homo sapiens_hsa046120.72209909
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68989480
49Vitamin B6 metabolism_Homo sapiens_hsa007500.67627440
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.67419377
51HTLV-I infection_Homo sapiens_hsa051660.66006510
52Sulfur metabolism_Homo sapiens_hsa009200.61574333
53Parkinsons disease_Homo sapiens_hsa050120.59981543
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57500777
55Cardiac muscle contraction_Homo sapiens_hsa042600.56991308
56Arginine biosynthesis_Homo sapiens_hsa002200.55734801
57Legionellosis_Homo sapiens_hsa051340.55648804
58Selenocompound metabolism_Homo sapiens_hsa004500.55167787
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52602125
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.52334322
61Primary immunodeficiency_Homo sapiens_hsa053400.52200292
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51823467
63Biosynthesis of amino acids_Homo sapiens_hsa012300.51318493
64Small cell lung cancer_Homo sapiens_hsa052220.51260352
65Arginine and proline metabolism_Homo sapiens_hsa003300.50892743
66Glutathione metabolism_Homo sapiens_hsa004800.49628806
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48648829
68Vitamin digestion and absorption_Homo sapiens_hsa049770.45776805
69Measles_Homo sapiens_hsa051620.45408272
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45181148
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43595064
72Apoptosis_Homo sapiens_hsa042100.43274144
73N-Glycan biosynthesis_Homo sapiens_hsa005100.42795861
74Alcoholism_Homo sapiens_hsa050340.42438537
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.41216984
76Oxidative phosphorylation_Homo sapiens_hsa001900.40069520
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39184580
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.38276546
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37854394
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37470467
81MicroRNAs in cancer_Homo sapiens_hsa052060.37155752
82Hepatitis B_Homo sapiens_hsa051610.36948745
83Hematopoietic cell lineage_Homo sapiens_hsa046400.36884091
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36247079
85Fructose and mannose metabolism_Homo sapiens_hsa000510.35699080
86Thyroid cancer_Homo sapiens_hsa052160.35651127
87Fatty acid metabolism_Homo sapiens_hsa012120.34937438
88Peroxisome_Homo sapiens_hsa041460.34290246
89Arachidonic acid metabolism_Homo sapiens_hsa005900.34193396
90Influenza A_Homo sapiens_hsa051640.32647647
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31949436
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31130956
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29422341
94Galactose metabolism_Homo sapiens_hsa000520.28390779
95Metabolic pathways_Homo sapiens_hsa011000.27817946
96Sulfur relay system_Homo sapiens_hsa041220.27645947
97Allograft rejection_Homo sapiens_hsa053300.24571655
98Butanoate metabolism_Homo sapiens_hsa006500.24148133
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23748901
100Collecting duct acid secretion_Homo sapiens_hsa049660.23009394
101Regulation of autophagy_Homo sapiens_hsa041400.22797187
102Carbon metabolism_Homo sapiens_hsa012000.22104841
103Shigellosis_Homo sapiens_hsa051310.19769403
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19740928
105Fatty acid degradation_Homo sapiens_hsa000710.17919594
106Hedgehog signaling pathway_Homo sapiens_hsa043400.17327813
107Notch signaling pathway_Homo sapiens_hsa043300.17292209
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16976922
109TGF-beta signaling pathway_Homo sapiens_hsa043500.16560848
110Autoimmune thyroid disease_Homo sapiens_hsa053200.15747701
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15571930
112Asthma_Homo sapiens_hsa053100.15153123
113Graft-versus-host disease_Homo sapiens_hsa053320.14954720
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14570479
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.14000293
116beta-Alanine metabolism_Homo sapiens_hsa004100.13156458
117Renin-angiotensin system_Homo sapiens_hsa046140.12641265
118Colorectal cancer_Homo sapiens_hsa052100.12311911
119HIF-1 signaling pathway_Homo sapiens_hsa040660.11672048
120Tryptophan metabolism_Homo sapiens_hsa003800.11084225
121Tyrosine metabolism_Homo sapiens_hsa003500.10833561
122Wnt signaling pathway_Homo sapiens_hsa043100.09487808
123Pathways in cancer_Homo sapiens_hsa052000.09479523
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09047718
125Bladder cancer_Homo sapiens_hsa052190.08353171
126Lysine degradation_Homo sapiens_hsa003100.08348426
127Phenylalanine metabolism_Homo sapiens_hsa003600.07279388
128Hippo signaling pathway_Homo sapiens_hsa043900.06585432
129Basal cell carcinoma_Homo sapiens_hsa052170.06479171
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06212231
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05918758
132Alzheimers disease_Homo sapiens_hsa050100.05665109
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.05485925
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.04892274
135Retinol metabolism_Homo sapiens_hsa008300.04819608

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