OIT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)9.79926700
2omega-hydroxylase P450 pathway (GO:0097267)9.74983720
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.35287280
4L-phenylalanine catabolic process (GO:0006559)7.35287280
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.04442220
6L-phenylalanine metabolic process (GO:0006558)7.04442220
7drug metabolic process (GO:0017144)6.64046156
8aromatic amino acid family catabolic process (GO:0009074)6.57763099
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.47725893
10oxidative demethylation (GO:0070989)6.03701444
11indole-containing compound catabolic process (GO:0042436)5.90500405
12indolalkylamine catabolic process (GO:0046218)5.90500405
13tryptophan catabolic process (GO:0006569)5.90500405
14kynurenine metabolic process (GO:0070189)5.82470930
15bile acid biosynthetic process (GO:0006699)5.81763349
16negative regulation of fibrinolysis (GO:0051918)5.79438060
17high-density lipoprotein particle remodeling (GO:0034375)5.73771224
18glyoxylate metabolic process (GO:0046487)5.71593203
19alpha-linolenic acid metabolic process (GO:0036109)5.68813576
20tryptophan metabolic process (GO:0006568)5.59169733
21peptidyl-glutamic acid carboxylation (GO:0017187)5.53745715
22protein carboxylation (GO:0018214)5.53745715
23regulation of fibrinolysis (GO:0051917)5.53465323
24urea cycle (GO:0000050)5.50371345
25urea metabolic process (GO:0019627)5.50371345
26opsonization (GO:0008228)5.46590601
27ethanol metabolic process (GO:0006067)5.43645325
28regulation of protein activation cascade (GO:2000257)5.26867684
29complement activation, alternative pathway (GO:0006957)5.24010131
30sulfur amino acid catabolic process (GO:0000098)5.18666376
31cysteine metabolic process (GO:0006534)5.16680193
32reverse cholesterol transport (GO:0043691)5.06146680
33nitrogen cycle metabolic process (GO:0071941)5.04180739
34bile acid metabolic process (GO:0008206)4.99563763
35negative regulation of protein activation cascade (GO:2000258)4.99253743
36regulation of cholesterol esterification (GO:0010872)4.93365608
37serine family amino acid catabolic process (GO:0009071)4.93078338
38positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.92982477
39protein-lipid complex remodeling (GO:0034368)4.90455679
40macromolecular complex remodeling (GO:0034367)4.90455679
41plasma lipoprotein particle remodeling (GO:0034369)4.90455679
42regulation of complement activation (GO:0030449)4.90136374
43phenylpropanoid metabolic process (GO:0009698)4.82223901
44regulation of humoral immune response (GO:0002920)4.81814986
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.81428025
46regulation of triglyceride catabolic process (GO:0010896)4.79035036
47aromatic amino acid family metabolic process (GO:0009072)4.77483437
48S-adenosylmethionine metabolic process (GO:0046500)4.75685017
49acute-phase response (GO:0006953)4.71862870
50disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.68282574
51killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.68282574
52tyrosine metabolic process (GO:0006570)4.67550720
53plasma lipoprotein particle clearance (GO:0034381)4.65920227
54phospholipid efflux (GO:0033700)4.64888128
55negative regulation of blood coagulation (GO:0030195)4.64432052
56negative regulation of hemostasis (GO:1900047)4.64432052
57regulation of plasminogen activation (GO:0010755)4.62013990
58triglyceride homeostasis (GO:0070328)4.60995708
59acylglycerol homeostasis (GO:0055090)4.60995708
60homocysteine metabolic process (GO:0050667)4.56133510
61negative regulation of cholesterol transport (GO:0032375)4.55469033
62negative regulation of sterol transport (GO:0032372)4.55469033
63alpha-amino acid catabolic process (GO:1901606)4.48429129
64amino-acid betaine metabolic process (GO:0006577)4.48287185
65lysine metabolic process (GO:0006553)4.42051897
66lysine catabolic process (GO:0006554)4.42051897
67cholesterol efflux (GO:0033344)4.36984944
68cellular ketone body metabolic process (GO:0046950)4.35858829
69bile acid and bile salt transport (GO:0015721)4.29405841
70flavonoid metabolic process (GO:0009812)4.29398300
71glycine metabolic process (GO:0006544)4.27348655
72imidazole-containing compound metabolic process (GO:0052803)4.23401477
73negative regulation of coagulation (GO:0050819)4.23149869
74indolalkylamine metabolic process (GO:0006586)4.20882478
75negative regulation of wound healing (GO:0061045)4.18431030
76fibrinolysis (GO:0042730)4.16190788
77plasma lipoprotein particle assembly (GO:0034377)4.16088010
78coenzyme catabolic process (GO:0009109)4.15787657
79arginine metabolic process (GO:0006525)4.13614601
80cellular glucuronidation (GO:0052695)4.13423276
81glutamate metabolic process (GO:0006536)4.10472928
82cellular amino acid catabolic process (GO:0009063)4.10021422
83alkaloid metabolic process (GO:0009820)4.09514060
84amine catabolic process (GO:0009310)4.08003503
85cellular biogenic amine catabolic process (GO:0042402)4.08003503
86low-density lipoprotein particle remodeling (GO:0034374)4.05275592
87blood coagulation, intrinsic pathway (GO:0007597)4.04105281
88aldehyde catabolic process (GO:0046185)4.00528888
89hormone catabolic process (GO:0042447)3.99958009
90benzene-containing compound metabolic process (GO:0042537)3.99531423
91serine family amino acid metabolic process (GO:0009069)3.98315827
92negative regulation of complement activation (GO:0045916)3.91200193
93cellular modified amino acid catabolic process (GO:0042219)3.89967946
94dicarboxylic acid biosynthetic process (GO:0043650)3.88723235
95ethanol oxidation (GO:0006069)3.88191037
96positive regulation of lipoprotein lipase activity (GO:0051006)3.86274531
97positive regulation of triglyceride lipase activity (GO:0061365)3.86274531
98phospholipid homeostasis (GO:0055091)3.84765076
99intestinal cholesterol absorption (GO:0030299)3.84527241
100drug catabolic process (GO:0042737)3.81075586
101serine family amino acid biosynthetic process (GO:0009070)3.80461692
102cholesterol homeostasis (GO:0042632)3.80246715
103cofactor catabolic process (GO:0051187)3.79702817
104very-low-density lipoprotein particle assembly (GO:0034379)3.78372539
105protein activation cascade (GO:0072376)3.77327477
106plasma lipoprotein particle organization (GO:0071827)3.77298906
107protein-lipid complex assembly (GO:0065005)3.76037639
108positive regulation of lipid catabolic process (GO:0050996)3.75986667
109ketone body metabolic process (GO:1902224)3.75588264
110sterol homeostasis (GO:0055092)3.73968823
111positive regulation of hemostasis (GO:1900048)3.72514629
112positive regulation of blood coagulation (GO:0030194)3.72514629
113negative regulation of lipase activity (GO:0060192)3.69602644
114glucuronate metabolic process (GO:0019585)3.68896716
115uronic acid metabolic process (GO:0006063)3.68896716
116complement activation (GO:0006956)3.64599823
117complement activation, classical pathway (GO:0006958)3.63222127
118regulation of cholesterol homeostasis (GO:2000188)3.60478453
119organic acid catabolic process (GO:0016054)3.60418464
120carboxylic acid catabolic process (GO:0046395)3.60418464
121protein-lipid complex subunit organization (GO:0071825)3.56546374
122lipoprotein metabolic process (GO:0042157)3.55961458
123xenobiotic metabolic process (GO:0006805)3.51764781
124regulation of bile acid biosynthetic process (GO:0070857)3.48638459
125heme transport (GO:0015886)3.46220063
126short-chain fatty acid metabolic process (GO:0046459)3.46161046
127acetyl-CoA metabolic process (GO:0006084)3.45585703
128acute inflammatory response (GO:0002526)3.45564021
129cytolysis (GO:0019835)3.43957407
130positive regulation of coagulation (GO:0050820)3.42525262
131fat-soluble vitamin biosynthetic process (GO:0042362)3.37643639
132regulation of acute inflammatory response (GO:0002673)3.32949433
133exogenous drug catabolic process (GO:0042738)10.4627054

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.25900118
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.07739304
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.71142772
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.45189207
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.28435435
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.02380445
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.95646607
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.93222394
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.81715204
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.58123189
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02613432
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7759955
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98310893
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96849998
15CLOCK_20551151_ChIP-Seq_293T_Human1.89367437
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65967932
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.58183869
18GATA1_22025678_ChIP-Seq_K562_Human1.55371114
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54683391
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53714675
21BCAT_22108803_ChIP-Seq_LS180_Human1.40548461
22HTT_18923047_ChIP-ChIP_STHdh_Human1.37956424
23* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34369678
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27622905
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.25109545
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22868300
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22235888
28* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21473802
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14123592
30RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12713726
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10516092
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.10109906
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04718783
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.02469873
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00525186
36ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99013852
37* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97874005
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96526601
39* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93479494
40SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90698107
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90675609
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89139489
43CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88443572
44CDX2_22108803_ChIP-Seq_LS180_Human0.87912072
45GATA4_25053715_ChIP-Seq_YYC3_Human0.86372367
46* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86134141
47* HNFA_21074721_ChIP-Seq_CACO-2_Human0.84714326
48IRF1_19129219_ChIP-ChIP_H3396_Human0.83510206
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82976903
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82944495
51* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82323793
52* PHF8_20622853_ChIP-Seq_HELA_Human0.80818810
53SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79596908
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78695688
55GATA1_19941826_ChIP-Seq_K562_Human0.78108184
56TP53_18474530_ChIP-ChIP_U2OS_Human0.77888595
57* NFYA_21822215_ChIP-Seq_K562_Human0.77159166
58AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76960734
59ZNF263_19887448_ChIP-Seq_K562_Human0.75315475
60ER_23166858_ChIP-Seq_MCF-7_Human0.75297275
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74594657
62SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73991216
63LXR_22292898_ChIP-Seq_THP-1_Human0.73872100
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73634580
65NFE2_27457419_Chip-Seq_LIVER_Mouse0.72806229
66* EZH2_27294783_Chip-Seq_NPCs_Mouse0.71416558
67TCF4_22108803_ChIP-Seq_LS180_Human0.70168640
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.70073806
69RARA_24833708_ChIP-Seq_LIVER_Mouse0.69719445
70ESR2_21235772_ChIP-Seq_MCF-7_Human0.69435825
71KLF5_20875108_ChIP-Seq_MESCs_Mouse0.69316739
72GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.66609149
73GATA2_21666600_ChIP-Seq_HMVEC_Human0.65288248
74MYC_19829295_ChIP-Seq_ESCs_Human0.64740292
75* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.64460741
76PCGF2_27294783_Chip-Seq_NPCs_Mouse0.64197288
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.64095090
78SOX2_19829295_ChIP-Seq_ESCs_Human0.63834268
79NANOG_19829295_ChIP-Seq_ESCs_Human0.63834268
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.63728226
81CBP_20019798_ChIP-Seq_JUKART_Human0.63196125
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.63196125
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.62620538
84* GATA1_19941827_ChIP-Seq_MEL_Mouse0.62341945
85* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62099905
86* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62099905
87GATA6_21074721_ChIP-Seq_CACO-2_Human0.61381383
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.61094834
89CBX2_22325352_ChIP-Seq_293T-Rex_Human0.60992482
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60913333
91GATA2_19941826_ChIP-Seq_K562_Human0.60017575
92BP1_19119308_ChIP-ChIP_Hs578T_Human0.59846334
93TCF4_18268006_ChIP-ChIP_LS174T_Human0.59842061
94ETV2_25802403_ChIP-Seq_MESCs_Mouse0.59560391
95RARB_24833708_ChIP-Seq_LIVER_Mouse0.59447452
96SUZ12_27294783_Chip-Seq_NPCs_Mouse0.58966588
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58782931
98NCOR_22424771_ChIP-Seq_293T_Human0.57912982
99RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57695294
100KAP1_22055183_ChIP-Seq_ESCs_Mouse0.56866510
101ESR1_21235772_ChIP-Seq_MCF-7_Human0.56782540
102STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56547048
103ETV1_20927104_ChIP-Seq_GIST48_Human0.56456645
104CEBPB_22108803_ChIP-Seq_LS180_Human0.56054305
105SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.55916683
106NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.55873671
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.55522082
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.54727791
109FOXH1_21741376_ChIP-Seq_EPCs_Human0.54705471
110GBX2_23144817_ChIP-Seq_PC3_Human0.54671847
111* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.54105668
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.53981215
113* TP63_23658742_ChIP-Seq_EP156T_Human0.53685980
114* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.53153597
115SOX2_21211035_ChIP-Seq_LN229_Human0.53004661
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.52921288
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.52884297
118ERG_20517297_ChIP-Seq_VCAP_Human0.52794964
119BRD4_27068464_Chip-Seq_AML-cells_Mouse0.52470674
120EGR1_19032775_ChIP-ChIP_M12_Human0.52308128
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.50666443
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.50291548
123MYC_19915707_ChIP-ChIP_AK7_Human0.50200916
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.48380227
125IRF8_27001747_Chip-Seq_BMDM_Mouse0.47643670
126* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47601705
127AR_20517297_ChIP-Seq_VCAP_Human0.47188856
128NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.47013333
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.45710223
130GATA6_25053715_ChIP-Seq_YYC3_Human0.45600856
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44830373
132FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.43341722
133FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.43214985
134P53_21459846_ChIP-Seq_SAOS-2_Human0.43048141
135SOX2_20726797_ChIP-Seq_SW620_Human0.42616514
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.42596337
137* FOXO3_23340844_ChIP-Seq_DLD1_Human0.42349200
138* CBP_21632823_ChIP-Seq_H3396_Human0.41997228
139* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.41306571
140* ESET_19884257_ChIP-Seq_ESCs_Mouse0.40369917
141ERG_21242973_ChIP-ChIP_JURKAT_Human0.39559632
142TAF2_19829295_ChIP-Seq_ESCs_Human0.38872961
143CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.38828354
144RACK7_27058665_Chip-Seq_MCF-7_Human0.38763732
145* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.38353241
146SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38279669
147ESR1_20079471_ChIP-ChIP_T-47D_Human0.37235632
148SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.36890896
149STAT1_17558387_ChIP-Seq_HELA_Human0.36890746
150ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.36467603

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.94887895
2MP0005360_urolithiasis7.30358033
3MP0005085_abnormal_gallbladder_physiolo6.15762639
4MP0005365_abnormal_bile_salt5.88836559
5MP0008875_abnormal_xenobiotic_pharmacok4.88143144
6MP0003806_abnormal_nucleotide_metabolis3.96232898
7MP0003252_abnormal_bile_duct3.72590187
8MP0010329_abnormal_lipoprotein_level3.58332700
9MP0009840_abnormal_foam_cell3.42253124
10MP0005083_abnormal_biliary_tract3.16411629
11MP0010368_abnormal_lymphatic_system2.83324036
12MP0003195_calcinosis2.66307501
13MP0005332_abnormal_amino_acid2.58042585
14MP0001666_abnormal_nutrient_absorption2.44858132
15MP0003191_abnormal_cellular_cholesterol2.42179695
16MP0000609_abnormal_liver_physiology2.16901931
17MP0002138_abnormal_hepatobiliary_system2.07588677
18MP0002118_abnormal_lipid_homeostasis2.02745188
19MP0004019_abnormal_vitamin_homeostasis2.01354272
20MP0005319_abnormal_enzyme/_coenzyme1.82808823
21MP0003868_abnormal_feces_composition1.82254484
22MP0009697_abnormal_copulation1.78266680
23MP0001764_abnormal_homeostasis1.51346118
24MP0005584_abnormal_enzyme/coenzyme_acti1.48219206
25MP0003705_abnormal_hypodermis_morpholog1.47063411
26MP0003656_abnormal_erythrocyte_physiolo1.46028390
27MP0005451_abnormal_body_composition1.42791479
28MP0003011_delayed_dark_adaptation1.35655015
29MP0003186_abnormal_redox_activity1.30683004
30MP0002132_abnormal_respiratory_system1.27351541
31MP0000598_abnormal_liver_morphology1.24696696
32MP0009643_abnormal_urine_homeostasis1.20210897
33MP0000604_amyloidosis1.17956164
34MP0009764_decreased_sensitivity_to1.17822983
35MP0005647_abnormal_sex_gland1.13530396
36MP0009763_increased_sensitivity_to1.07169742
37MP0005167_abnormal_blood-brain_barrier1.01820153
38MP0002282_abnormal_trachea_morphology1.01354063
39MP0001879_abnormal_lymphatic_vessel0.98938038
40MP0002254_reproductive_system_inflammat0.98664744
41MP0008469_abnormal_protein_level0.96590532
42MP0005636_abnormal_mineral_homeostasis0.86990545
43MP0008872_abnormal_physiological_respon0.86089987
44MP0009642_abnormal_blood_homeostasis0.85287110
45MP0005187_abnormal_penis_morphology0.84435506
46MP0005376_homeostasis/metabolism_phenot0.82465661
47MP0009765_abnormal_xenobiotic_induced0.78815345
48MP0005408_hypopigmentation0.78320744
49MP0005464_abnormal_platelet_physiology0.78250076
50MP0005084_abnormal_gallbladder_morpholo0.73799749
51MP0003690_abnormal_glial_cell0.73316276
52MP0003724_increased_susceptibility_to0.73253323
53MP0005670_abnormal_white_adipose0.71204688
54MP0004130_abnormal_muscle_cell0.70658050
55MP0002078_abnormal_glucose_homeostasis0.70314659
56MP0006036_abnormal_mitochondrial_physio0.67661401
57MP0003436_decreased_susceptibility_to0.64984026
58MP0002971_abnormal_brown_adipose0.64481896
59MP0009053_abnormal_anal_canal0.63654000
60MP0005220_abnormal_exocrine_pancreas0.62673502
61MP0000639_abnormal_adrenal_gland0.62458996
62MP0005334_abnormal_fat_pad0.62446092
63MP0005266_abnormal_metabolism0.60921911
64MP0003879_abnormal_hair_cell0.59807074
65MP0001756_abnormal_urination0.57474139
66MP0002249_abnormal_larynx_morphology0.56988398
67MP0000249_abnormal_blood_vessel0.56639000
68MP0001661_extended_life_span0.56275025
69MP0005535_abnormal_body_temperature0.55048373
70MP0004883_abnormal_blood_vessel0.54916530
71MP0003638_abnormal_response/metabolism_0.54173756
72MP0004272_abnormal_basement_membrane0.53988435
73MP0000467_abnormal_esophagus_morphology0.53336179
74MP0006082_CNS_inflammation0.53045144
75MP0003329_amyloid_beta_deposits0.52880190
76MP0004782_abnormal_surfactant_physiolog0.50610590
77MP0003075_altered_response_to0.50151679
78MP0003300_gastrointestinal_ulcer0.49881803
79MP0008873_increased_physiological_sensi0.48991924
80MP0002876_abnormal_thyroid_physiology0.48134008
81MP0002136_abnormal_kidney_physiology0.48086248
82MP0005058_abnormal_lysosome_morphology0.47893719
83MP0005448_abnormal_energy_balance0.46563011
84MP0005395_other_phenotype0.46497355
85MP0005164_abnormal_response_to0.45769813
86MP0008874_decreased_physiological_sensi0.45754303
87MP0005166_decreased_susceptibility_to0.44990915
88MP0001915_intracranial_hemorrhage0.43499856
89MP0009785_altered_susceptibility_to0.43158500
90MP0001243_abnormal_dermal_layer0.42056309
91MP0003718_maternal_effect0.39954042
92MP0003303_peritoneal_inflammation0.39774813
93MP0005595_abnormal_vascular_smooth0.39356031
94MP0002928_abnormal_bile_duct0.39295627
95MP0002128_abnormal_blood_circulation0.39123327
96MP0004264_abnormal_extraembryonic_tissu0.39112097
97MP0000230_abnormal_systemic_arterial0.38757122
98MP0001845_abnormal_inflammatory_respons0.38644840
99MP0006035_abnormal_mitochondrial_morpho0.38319805
100MP0000013_abnormal_adipose_tissue0.35691504
101MP0002295_abnormal_pulmonary_circulatio0.34931683
102MP0005023_abnormal_wound_healing0.34333337
103MP0002332_abnormal_exercise_endurance0.32490841
104MP0003953_abnormal_hormone_level0.32272933
105MP0005248_abnormal_Harderian_gland0.32078384
106MP0009672_abnormal_birth_weight0.31817204
107MP0005666_abnormal_adipose_tissue0.31545191
108MP0009115_abnormal_fat_cell0.30777174
109MP0002168_other_aberrant_phenotype0.30556806
110MP0002419_abnormal_innate_immunity0.30124225
111MP0005409_darkened_coat_color0.25878180
112MP0003183_abnormal_peptide_metabolism0.23804373
113MP0005165_increased_susceptibility_to0.22121997
114MP0003633_abnormal_nervous_system0.20713926
115MP0010155_abnormal_intestine_physiology0.20435123
116MP0001986_abnormal_taste_sensitivity0.20018698
117MP0001851_eye_inflammation0.19214726
118MP0006054_spinal_hemorrhage0.19212889

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.61076393
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.10974963
3Intrahepatic cholestasis (HP:0001406)7.06845459
4Prolonged partial thromboplastin time (HP:0003645)6.56919213
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.40627800
6Hypobetalipoproteinemia (HP:0003563)6.26349603
7Xanthomatosis (HP:0000991)6.24432039
8Hyperlipoproteinemia (HP:0010980)5.51309384
9Complement deficiency (HP:0004431)5.15565688
10Joint hemorrhage (HP:0005261)5.11129485
11Hypolipoproteinemia (HP:0010981)4.81024783
12Abnormality of the common coagulation pathway (HP:0010990)4.50645461
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.41579680
14Hyperammonemia (HP:0001987)4.39629719
15Epidermoid cyst (HP:0200040)4.34864190
16Hypoalphalipoproteinemia (HP:0003233)4.32243036
17Hyperglycinemia (HP:0002154)4.11298449
18Abnormality of methionine metabolism (HP:0010901)4.08870601
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.05878538
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.01069262
21Fat malabsorption (HP:0002630)4.00116199
22Ketosis (HP:0001946)3.99725191
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.90316919
24Abnormality of the intrinsic pathway (HP:0010989)3.86258883
25Abnormality of complement system (HP:0005339)3.83710262
26Hypercholesterolemia (HP:0003124)3.70951326
27Hypoglycemic coma (HP:0001325)3.69099657
28Abnormality of pyrimidine metabolism (HP:0004353)3.68453655
29Abnormality of serine family amino acid metabolism (HP:0010894)3.64419491
30Abnormality of glycine metabolism (HP:0010895)3.64419491
31Hyperglycinuria (HP:0003108)3.63619934
32Conjugated hyperbilirubinemia (HP:0002908)3.47907654
33Hyperbilirubinemia (HP:0002904)3.32346368
34Myocardial infarction (HP:0001658)3.17684456
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17426423
36Hepatocellular carcinoma (HP:0001402)3.15735191
37Abnormality of fatty-acid metabolism (HP:0004359)3.13574477
38Spontaneous abortion (HP:0005268)3.02969644
39Steatorrhea (HP:0002570)3.01409067
40Hypochromic microcytic anemia (HP:0004840)3.01066223
41Delayed CNS myelination (HP:0002188)2.93390533
42Abnormality of nucleobase metabolism (HP:0010932)2.92253376
43Systemic lupus erythematosus (HP:0002725)2.81737957
44Abnormality of serum amino acid levels (HP:0003112)2.79678566
45Osteomalacia (HP:0002749)2.78015158
46Skin nodule (HP:0200036)2.77267239
47Ketoacidosis (HP:0001993)2.74161129
48Esophageal varix (HP:0002040)2.71515511
49Acanthocytosis (HP:0001927)2.71474638
50Vascular calcification (HP:0004934)2.68273267
51Neonatal hypoglycemia (HP:0001998)2.64923329
52Metabolic acidosis (HP:0001942)2.60057784
53Glomerulonephritis (HP:0000099)2.57677713
54Abnormality of purine metabolism (HP:0004352)2.54153237
55Abnormal gallbladder morphology (HP:0012437)2.53668937
56Cholelithiasis (HP:0001081)2.50134258
57Recurrent gram-negative bacterial infections (HP:0005420)2.49079857
58Amyloidosis (HP:0011034)2.46781469
59Mitral stenosis (HP:0001718)2.45085038
60Spastic diplegia (HP:0001264)2.44742804
61Menorrhagia (HP:0000132)2.43719084
62Gingival bleeding (HP:0000225)2.43459721
63Cholecystitis (HP:0001082)2.42881447
64Abnormal gallbladder physiology (HP:0012438)2.42881447
65Hemorrhage of the eye (HP:0011885)2.42186930
66Dicarboxylic aciduria (HP:0003215)2.41468334
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41468334
68Cardiovascular calcification (HP:0011915)2.41123282
69Fair hair (HP:0002286)2.37262075
70Lethargy (HP:0001254)2.34538610
71Thrombophlebitis (HP:0004418)2.33521559
72Hypoglycemic seizures (HP:0002173)2.29865236
73Poikilocytosis (HP:0004447)2.25453393
74Purpura (HP:0000979)2.24120183
75Irritability (HP:0000737)2.21336438
76Neonatal onset (HP:0003623)2.21222852
77Malnutrition (HP:0004395)2.17932227
78Joint swelling (HP:0001386)2.14823310
79Gout (HP:0001997)2.14041450
80Abnormality of vitamin metabolism (HP:0100508)2.13448269
81Cerebral edema (HP:0002181)2.12027643
82Sensorimotor neuropathy (HP:0007141)2.11841305
83Pancreatitis (HP:0001733)2.07540877
84Abnormality of iron homeostasis (HP:0011031)2.07449794
85Glycosuria (HP:0003076)2.06552500
86Abnormality of urine glucose concentration (HP:0011016)2.06552500
87Abnormality of the gallbladder (HP:0005264)2.05441056
88Polycythemia (HP:0001901)2.05382279
89Hyperphosphaturia (HP:0003109)2.02679987
90Enlarged kidneys (HP:0000105)2.02196699
91Elevated alkaline phosphatase (HP:0003155)2.01926246
92Abnormality of transition element cation homeostasis (HP:0011030)1.99183953
93Brushfield spots (HP:0001088)1.98922095
94Reticulocytosis (HP:0001923)1.98883266
95Pulmonary embolism (HP:0002204)1.95576854
96Opisthotonus (HP:0002179)1.94525142
97Vomiting (HP:0002013)1.94472062
98Late onset (HP:0003584)1.93280332
99Abnormality of proline metabolism (HP:0010907)1.91901223
100Hydroxyprolinuria (HP:0003080)1.91901223
101Nonimmune hydrops fetalis (HP:0001790)1.90399078
102Rickets (HP:0002748)1.87976048
103Conjunctival telangiectasia (HP:0000524)1.87312331
104Abnormality of alkaline phosphatase activity (HP:0004379)1.85640560
105Nephritis (HP:0000123)1.85145558
106Abnormal cartilage morphology (HP:0002763)1.84363331
107Generalized aminoaciduria (HP:0002909)1.83048787
108Abnormal enzyme/coenzyme activity (HP:0012379)1.81869475
109Hypophosphatemic rickets (HP:0004912)1.80809920
110Stroke (HP:0001297)1.80445304
111Hyperinsulinemic hypoglycemia (HP:0000825)1.80262869
112Increased mean platelet volume (HP:0011877)1.80219407
113Epistaxis (HP:0000421)1.80191849
114Cerebral palsy (HP:0100021)1.78843937
115Abnormal delivery (HP:0001787)1.77918719
116Reduced antithrombin III activity (HP:0001976)1.69784892
117Abnormal urine phosphate concentration (HP:0012599)1.68136800
118Atrioventricular block (HP:0001678)1.66734765
119Facial shape deformation (HP:0011334)1.61980901
120Potter facies (HP:0002009)1.61980901
121Arthropathy (HP:0003040)1.59151842
122Generalized hypopigmentation of hair (HP:0011358)1.57430229
123Nephrolithiasis (HP:0000787)1.51078348
124Increased serum ferritin (HP:0003281)1.50473846
125Alkalosis (HP:0001948)1.47107082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.66445923
2MAP3K124.82365681
3KDR4.80639009
4TIE14.64824596
5ERN14.52935540
6FGFR43.95110508
7SIK13.83730461
8PDK22.83331129
9PKN22.82934457
10MYLK2.64322588
11TAOK32.57809715
12ERBB42.30504488
13FER2.18395299
14ARAF2.14392649
15MST1R2.13721035
16INSRR2.06906265
17TRIB32.04517899
18AKT31.92122778
19FLT31.84312181
20TGFBR21.83387506
21MAP4K21.82304946
22ACVR1B1.80641606
23PTK61.78423082
24MAP2K41.78120900
25TYK21.72745034
26EPHA41.70857265
27WNK31.65158841
28MAPK111.61381662
29MAP2K31.51050018
30NEK91.35586513
31TBK11.34878279
32PIK3CA1.34552852
33PIK3CG1.33896136
34LATS11.32888337
35DAPK21.28534590
36ABL21.25269858
37JAK21.22721961
38MAP3K111.17896894
39MAP3K91.11687473
40ILK1.09133116
41MAP3K31.08308293
42JAK11.07438690
43MAP3K131.05483721
44EPHB11.05457500
45MET1.03526420
46NLK1.02325975
47RIPK10.98771060
48MAP3K100.98734875
49PRKAA20.96425274
50FGFR20.95646860
51MAP3K140.95584883
52MAP3K20.94645531
53GRK10.92702533
54GRK60.91208174
55MAPK120.88061447
56MAP3K70.85473237
57CSK0.85342202
58MAPK40.84177882
59ERBB20.83224017
60CDK60.82357519
61PRKCG0.76945722
62PTK20.76417141
63MAP4K10.75903255
64PTK2B0.75736814
65TGFBR10.75160891
66PRKG10.74574162
67PRKCZ0.68248105
68STK160.68166643
69NTRK30.67580651
70FRK0.66878659
71PRKACG0.65719611
72BMPR1B0.63505656
73GSK3A0.61710970
74PRKACA0.59184102
75BMX0.58963012
76KSR10.57329729
77IKBKE0.57081396
78KSR20.56454702
79DYRK1B0.55755847
80CSF1R0.55193523
81EPHA20.54887877
82PINK10.53384586
83RET0.53085820
84IRAK30.52459250
85MAPK70.52126737
86CAMK1D0.52012536
87EPHB20.51747039
88IGF1R0.50636858
89PRKCE0.50178946
90KIT0.50077850
91EPHA30.49355613
92SRC0.49103238
93FGFR30.49044080
94EGFR0.48833120
95FES0.48118458
96PAK40.47548136
97PRKG20.47501373
98PRKCA0.47435393
99MAP2K10.46986831
100PRKAA10.46725804
101BRAF0.45866301
102PDPK10.44005247
103SGK30.42533460
104MAP3K10.41844278
105MAP2K60.41807006
106TNK20.41243179
107PRKCQ0.40462587
108PBK0.39972617
109MOS0.38889596
110ZAP700.37878080
111MAPK150.37218573
112TAOK20.37201097
113PRKACB0.36978836
114CSNK1D0.36127531
115STK38L0.34864185
116YES10.34578795
117CAMK2G0.34571296
118SGK4940.34254455
119SGK2230.34254455
120SGK20.33782576
121CDK40.33144539
122DAPK10.33114515
123JAK30.31567558
124MTOR0.31315132
125MAP2K20.30927128
126BLK0.30635172
127MAP3K50.30512845
128PRKCB0.29436641
129ICK0.28986518
130CAMK40.28681217
131CDK90.28390741
132ITK0.28336953
133PDK10.26581008
134CSNK1G10.26403272
135OBSCN0.25590755
136LYN0.24660421
137RPS6KA30.24513414
138ABL10.24221247
139ROCK10.23714970
140PAK30.22460436
141STK30.22437676
142LRRK20.22108198
143BCR0.21490027
144STK100.17587562
145MAP3K60.17274538
146PDGFRA0.17217869
147CHUK0.16653625

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.56635886
2Nitrogen metabolism_Homo sapiens_hsa009103.70645887
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40424155
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31986380
5Arginine biosynthesis_Homo sapiens_hsa002203.16475144
6Complement and coagulation cascades_Homo sapiens_hsa046103.00359741
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75342738
8Tryptophan metabolism_Homo sapiens_hsa003802.65481206
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61841010
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49922143
11Fatty acid degradation_Homo sapiens_hsa000712.48388523
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31361384
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29420552
14Butanoate metabolism_Homo sapiens_hsa006502.10032380
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09595112
16Peroxisome_Homo sapiens_hsa041462.05700133
17Staphylococcus aureus infection_Homo sapiens_hsa051501.95315993
18Chemical carcinogenesis_Homo sapiens_hsa052041.93022267
19PPAR signaling pathway_Homo sapiens_hsa033201.91954414
20Histidine metabolism_Homo sapiens_hsa003401.88765407
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88658420
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.88410447
23Propanoate metabolism_Homo sapiens_hsa006401.84703842
24Fatty acid metabolism_Homo sapiens_hsa012121.80076504
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.79695881
26Caffeine metabolism_Homo sapiens_hsa002321.72799557
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67717289
28Retinol metabolism_Homo sapiens_hsa008301.66547379
29beta-Alanine metabolism_Homo sapiens_hsa004101.66384473
30Selenocompound metabolism_Homo sapiens_hsa004501.60195759
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57237159
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56935391
33Bile secretion_Homo sapiens_hsa049761.54410950
34Phenylalanine metabolism_Homo sapiens_hsa003601.49278614
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42208109
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40585128
37Tyrosine metabolism_Homo sapiens_hsa003501.36084949
38Fatty acid elongation_Homo sapiens_hsa000621.30341156
39Starch and sucrose metabolism_Homo sapiens_hsa005001.29196233
40Sulfur metabolism_Homo sapiens_hsa009201.29169972
41Pyruvate metabolism_Homo sapiens_hsa006201.28718239
42ABC transporters_Homo sapiens_hsa020101.24446881
43Steroid biosynthesis_Homo sapiens_hsa001001.23347470
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.22912688
45Fat digestion and absorption_Homo sapiens_hsa049751.18068571
46Folate biosynthesis_Homo sapiens_hsa007901.16574593
47Biosynthesis of amino acids_Homo sapiens_hsa012301.13816251
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11558976
49Carbon metabolism_Homo sapiens_hsa012001.09078830
50Arginine and proline metabolism_Homo sapiens_hsa003300.95293380
51Sulfur relay system_Homo sapiens_hsa041220.92283867
52Vitamin B6 metabolism_Homo sapiens_hsa007500.91423208
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.91259592
54Vitamin digestion and absorption_Homo sapiens_hsa049770.89554209
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85890340
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.85601366
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84057003
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80621718
59Lysine degradation_Homo sapiens_hsa003100.79811682
60One carbon pool by folate_Homo sapiens_hsa006700.75759483
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68599660
62Glycerolipid metabolism_Homo sapiens_hsa005610.65609145
63Glutathione metabolism_Homo sapiens_hsa004800.60677467
64Pentose phosphate pathway_Homo sapiens_hsa000300.57397136
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51834310
66Fatty acid biosynthesis_Homo sapiens_hsa000610.47682246
67Metabolic pathways_Homo sapiens_hsa011000.41912846
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35723034
69Prion diseases_Homo sapiens_hsa050200.33594903
70Galactose metabolism_Homo sapiens_hsa000520.31711378
71Insulin resistance_Homo sapiens_hsa049310.27079928
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.23602618
73Fructose and mannose metabolism_Homo sapiens_hsa000510.19717695
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19516499
75Mineral absorption_Homo sapiens_hsa049780.17339933
76Linoleic acid metabolism_Homo sapiens_hsa005910.13384057
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11504299
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.09783588
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08530908
80Serotonergic synapse_Homo sapiens_hsa047260.07612491
81Glucagon signaling pathway_Homo sapiens_hsa049220.04120307
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.03958592
83Other glycan degradation_Homo sapiens_hsa005110.01032668
84AMPK signaling pathway_Homo sapiens_hsa041520.00024607
85Circadian rhythm_Homo sapiens_hsa04710-0.2597612
86Regulation of autophagy_Homo sapiens_hsa04140-0.2195094
87Platelet activation_Homo sapiens_hsa04611-0.2115124
88Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2100499
89Bladder cancer_Homo sapiens_hsa05219-0.2014275
90Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1993165
91N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1926420
92Ether lipid metabolism_Homo sapiens_hsa00565-0.1825116
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1741205
94Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1508555
95Pertussis_Homo sapiens_hsa05133-0.1478251
96Lysosome_Homo sapiens_hsa04142-0.1448102
97Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1377893
98Amoebiasis_Homo sapiens_hsa05146-0.1296219
99Insulin signaling pathway_Homo sapiens_hsa04910-0.1249460
100Malaria_Homo sapiens_hsa05144-0.1219258
101Hepatitis C_Homo sapiens_hsa05160-0.1149913
102Renin-angiotensin system_Homo sapiens_hsa04614-0.1133122
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1118657
104Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1032900
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0860614
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0848599
107African trypanosomiasis_Homo sapiens_hsa05143-0.0669532
108Sphingolipid metabolism_Homo sapiens_hsa00600-0.0623080
109Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0480813
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0312072
111Protein digestion and absorption_Homo sapiens_hsa04974-0.0124561

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »