OLA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.56833448
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.45785893
3formation of translation preinitiation complex (GO:0001731)4.44349233
4ribosomal large subunit biogenesis (GO:0042273)4.42394759
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.34581490
6translational termination (GO:0006415)4.33527400
7viral transcription (GO:0019083)4.27611290
8nuclear pore complex assembly (GO:0051292)4.16556541
9ribosomal small subunit biogenesis (GO:0042274)4.09716751
10nucleobase biosynthetic process (GO:0046112)4.07030700
11translational initiation (GO:0006413)3.99655412
12cullin deneddylation (GO:0010388)3.94263931
13DNA unwinding involved in DNA replication (GO:0006268)3.92796867
14translational elongation (GO:0006414)3.91410302
15ATP synthesis coupled proton transport (GO:0015986)3.90788790
16energy coupled proton transport, down electrochemical gradient (GO:0015985)3.90788790
17establishment of integrated proviral latency (GO:0075713)3.87809498
18purine nucleobase biosynthetic process (GO:0009113)3.83870028
19ribonucleoprotein complex biogenesis (GO:0022613)3.83171800
20cellular protein complex disassembly (GO:0043624)3.75143889
21ribosome assembly (GO:0042255)3.65118583
22protein deneddylation (GO:0000338)3.59181752
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.58805756
24ribosome biogenesis (GO:0042254)3.52429078
25peptidyl-arginine omega-N-methylation (GO:0035247)3.52280949
26ribosomal small subunit assembly (GO:0000028)3.51372506
27cotranslational protein targeting to membrane (GO:0006613)3.44779202
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43845958
29regulation of translational fidelity (GO:0006450)3.40674949
30DNA replication initiation (GO:0006270)3.39762671
31protein targeting to ER (GO:0045047)3.38831632
32rRNA processing (GO:0006364)3.36784916
33telomere maintenance via semi-conservative replication (GO:0032201)3.35611113
34viral life cycle (GO:0019058)3.34219963
35spliceosomal snRNP assembly (GO:0000387)3.31233682
36sister chromatid segregation (GO:0000819)3.30989744
37DNA replication checkpoint (GO:0000076)3.29029188
38histone arginine methylation (GO:0034969)3.26293606
39protein localization to chromosome, centromeric region (GO:0071459)3.25965320
40rRNA metabolic process (GO:0016072)3.25958076
41IMP biosynthetic process (GO:0006188)3.25372964
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.25172150
43protein complex disassembly (GO:0043241)3.24837709
44DNA topological change (GO:0006265)3.24410182
45cellular component biogenesis (GO:0044085)3.23250983
46protein localization to endoplasmic reticulum (GO:0070972)3.22358211
47translation (GO:0006412)3.22160600
48DNA ligation (GO:0006266)3.21153642
49mitotic chromosome condensation (GO:0007076)3.20308364
50mitotic metaphase plate congression (GO:0007080)3.19971219
51macromolecular complex disassembly (GO:0032984)3.18477660
52kinetochore organization (GO:0051383)3.18433848
53peptidyl-arginine methylation (GO:0018216)3.18330098
54peptidyl-arginine N-methylation (GO:0035246)3.18330098
55negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17590715
56regulation of translational termination (GO:0006449)3.17549517
57transcription elongation from RNA polymerase I promoter (GO:0006362)3.14472071
58DNA replication-independent nucleosome organization (GO:0034724)3.14180878
59DNA replication-independent nucleosome assembly (GO:0006336)3.14180878
60regulation of mitochondrial translation (GO:0070129)3.13597074
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11424416
62DNA damage response, detection of DNA damage (GO:0042769)3.10026390
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09377670
64histone exchange (GO:0043486)3.05999241
65chaperone-mediated protein complex assembly (GO:0051131)3.04593524
66DNA strand elongation involved in DNA replication (GO:0006271)3.04321377
67nucleobase-containing small molecule interconversion (GO:0015949)3.03242862
68pseudouridine synthesis (GO:0001522)3.02229102
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02109032
70mitotic sister chromatid cohesion (GO:0007064)3.01642808
71L-serine metabolic process (GO:0006563)3.01251980
72double-strand break repair via nonhomologous end joining (GO:0006303)3.00353388
73non-recombinational repair (GO:0000726)3.00353388
74pore complex assembly (GO:0046931)3.00175099
75folic acid-containing compound biosynthetic process (GO:0009396)3.00115366
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.99589324
77IMP metabolic process (GO:0046040)2.99268794
78protein neddylation (GO:0045116)2.98588294
79tRNA aminoacylation for protein translation (GO:0006418)2.98009431
807-methylguanosine mRNA capping (GO:0006370)2.97788832
817-methylguanosine RNA capping (GO:0009452)2.97302057
82RNA capping (GO:0036260)2.97302057
83protein localization to kinetochore (GO:0034501)2.96806276
84metaphase plate congression (GO:0051310)2.95843231
85chromatin remodeling at centromere (GO:0031055)2.95584361
86spindle checkpoint (GO:0031577)2.94875887
87de novo protein folding (GO:0006458)2.93761715
88mitotic spindle checkpoint (GO:0071174)2.93509936
89spliceosomal complex assembly (GO:0000245)2.92296695
90amino acid activation (GO:0043038)2.91605080
91tRNA aminoacylation (GO:0043039)2.91605080
92oxidative phosphorylation (GO:0006119)2.91172460
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91151533
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91151533
95negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91151533
96negative regulation of mitotic sister chromatid separation (GO:2000816)2.91151533
97negative regulation of sister chromatid segregation (GO:0033046)2.91151533
98mitotic recombination (GO:0006312)2.90617041
99termination of RNA polymerase I transcription (GO:0006363)2.90271119
100negative regulation of chromosome segregation (GO:0051985)2.89747420
101regulation of centriole replication (GO:0046599)2.89186816
102transcription elongation from RNA polymerase III promoter (GO:0006385)2.88607863
103termination of RNA polymerase III transcription (GO:0006386)2.88607863
104negative regulation of ligase activity (GO:0051352)2.88106583
105negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.88106583
106telomere maintenance via recombination (GO:0000722)2.87896552
107CENP-A containing nucleosome assembly (GO:0034080)2.86215183
108DNA replication-dependent nucleosome organization (GO:0034723)2.85975144
109DNA replication-dependent nucleosome assembly (GO:0006335)2.85975144
110chaperone-mediated protein transport (GO:0072321)2.85397457
111mitotic nuclear envelope disassembly (GO:0007077)2.85296045
112kinetochore assembly (GO:0051382)2.84871659
113nuclear pore organization (GO:0006999)2.84648751
114proteasome assembly (GO:0043248)2.84400327
115DNA strand elongation (GO:0022616)2.84135326
116protein localization to mitochondrion (GO:0070585)2.84128694
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.84075939
118mitotic sister chromatid segregation (GO:0000070)2.83184063
119establishment of protein localization to mitochondrion (GO:0072655)2.82791632
120cell cycle G1/S phase transition (GO:0044843)2.82163413
121G1/S transition of mitotic cell cycle (GO:0000082)2.82163413
122establishment of viral latency (GO:0019043)2.81899669
123guanosine-containing compound biosynthetic process (GO:1901070)2.79615601
124mitotic spindle assembly checkpoint (GO:0007094)2.79032441
125mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78296128
126regulation of chromosome segregation (GO:0051983)2.78133539
127heterochromatin organization (GO:0070828)2.77407986
128regulation of cellular amino acid metabolic process (GO:0006521)2.76337010
129membrane disassembly (GO:0030397)2.75958828
130nuclear envelope disassembly (GO:0051081)2.75958828
131spindle assembly checkpoint (GO:0071173)2.75597293
132positive regulation of cellular response to oxidative stress (GO:1900409)2.75408846
133positive regulation of response to oxidative stress (GO:1902884)2.75408846
134synaptic vesicle exocytosis (GO:0016079)2.75249454
135respiratory electron transport chain (GO:0022904)2.73731474
136ATP-dependent chromatin remodeling (GO:0043044)2.71917774
137UTP biosynthetic process (GO:0006228)2.71003283
138nuclear-transcribed mRNA catabolic process (GO:0000956)2.68999866
139positive regulation of ligase activity (GO:0051351)2.68197581
140regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.68051169
141regulation of mitotic metaphase/anaphase transition (GO:0030071)2.68051169

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.81257129
2MYC_18555785_ChIP-Seq_MESCs_Mouse5.17230193
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.90810495
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82761298
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.57893295
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.55874447
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.46117202
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.37320860
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.29488003
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.25926582
11MYC_19030024_ChIP-ChIP_MESCs_Mouse3.09752736
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.99719153
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92513543
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90215920
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.89312245
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.87110509
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66227227
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59912749
19XRN2_22483619_ChIP-Seq_HELA_Human2.43255907
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38308683
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36342319
22VDR_23849224_ChIP-Seq_CD4+_Human2.31460390
23DCP1A_22483619_ChIP-Seq_HELA_Human2.24426376
24TTF2_22483619_ChIP-Seq_HELA_Human2.23317568
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21812758
26ELK1_19687146_ChIP-ChIP_HELA_Human2.20884979
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.13758069
28AR_21909140_ChIP-Seq_LNCAP_Human2.13487909
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12947317
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10623163
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05539390
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00739842
33E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00068558
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96138805
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.93569281
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93034814
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92248327
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85653364
39FOXP3_21729870_ChIP-Seq_TREG_Human1.84811550
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82663907
41FUS_26573619_Chip-Seq_HEK293_Human1.82115438
42GABP_19822575_ChIP-Seq_HepG2_Human1.77215052
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.72737989
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71409770
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.64312430
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62623199
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58844649
48EZH2_22144423_ChIP-Seq_EOC_Human1.53130266
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51931408
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47113509
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.46200162
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45961336
53MYC_18940864_ChIP-ChIP_HL60_Human1.38723302
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37653182
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34016749
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33611000
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29990577
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24857748
59TAF15_26573619_Chip-Seq_HEK293_Human1.24790653
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24476299
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23789714
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.23705938
63EWS_26573619_Chip-Seq_HEK293_Human1.22265604
64KDM5A_27292631_Chip-Seq_BREAST_Human1.20674020
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20248239
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19834809
67SOX17_20123909_ChIP-Seq_XEN_Mouse1.17202481
68CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.16494752
69SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13838796
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12147981
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10326397
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09387475
73ZNF274_21170338_ChIP-Seq_K562_Hela1.09076782
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.03252721
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02966314
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02088121
77* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01653184
78KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97068880
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96960302
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95545709
81SALL1_21062744_ChIP-ChIP_HESCs_Human0.95350525
82ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94675874
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93923947
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93615609
85SRF_21415370_ChIP-Seq_HL-1_Mouse0.93298637
86TP63_19390658_ChIP-ChIP_HaCaT_Human0.90840057
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89997900
88TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89995999
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88369251
90STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88225042
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.88081551
92CIITA_25753668_ChIP-Seq_RAJI_Human0.84782294
93CHD1_26751641_Chip-Seq_LNCaP_Human0.84400653
94EGR1_19374776_ChIP-ChIP_THP-1_Human0.84110625
95E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82729002
96NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82682902
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82471528
98ZNF263_19887448_ChIP-Seq_K562_Human0.81541741
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80801736
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80242985
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79029091
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.78183444
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77927918
104CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77553662
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77034155
106POU5F1_16153702_ChIP-ChIP_HESCs_Human0.76527521
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74982020
108NANOG_16153702_ChIP-ChIP_HESCs_Human0.74975860
109TCF3_18692474_ChIP-Seq_MEFs_Mouse0.74430574
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74299174
111REST_19997604_ChIP-ChIP_NEURONS_Mouse0.74025579
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.73387298
113ELF5_23300383_ChIP-Seq_T47D_Human0.72983735
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72021435
115IGF1R_20145208_ChIP-Seq_DFB_Human0.70434949
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.70096816
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.69729513
118SOX2_18692474_ChIP-Seq_MEFs_Mouse0.67481306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.89315594
2MP0004957_abnormal_blastocyst_morpholog3.77623936
3MP0004859_abnormal_synaptic_plasticity3.45681638
4MP0003693_abnormal_embryo_hatching3.43127619
5MP0003123_paternal_imprinting3.40631719
6MP0010094_abnormal_chromosome_stability3.09857573
7MP0009379_abnormal_foot_pigmentation2.78204294
8MP0001968_abnormal_touch/_nociception2.61861162
9MP0002736_abnormal_nociception_after2.60111163
10MP0003635_abnormal_synaptic_transmissio2.54005132
11MP0001529_abnormal_vocalization2.52610651
12MP0003111_abnormal_nucleus_morphology2.51015781
13MP0008057_abnormal_DNA_replication2.42118249
14MP0003077_abnormal_cell_cycle2.32765527
15MP0008932_abnormal_embryonic_tissue2.31544438
16MP0006292_abnormal_olfactory_placode2.24052537
17MP0003941_abnormal_skin_development2.17823996
18MP0004270_analgesia2.16123411
19MP0008877_abnormal_DNA_methylation2.13664271
20MP0002063_abnormal_learning/memory/cond2.11434589
21MP0009745_abnormal_behavioral_response2.09040493
22MP0001293_anophthalmia1.93700116
23MP0001730_embryonic_growth_arrest1.93305590
24MP0002735_abnormal_chemical_nociception1.88008531
25MP0001440_abnormal_grooming_behavior1.83242871
26MP0002064_seizures1.79796661
27MP0003121_genomic_imprinting1.79751220
28MP0008058_abnormal_DNA_repair1.79640532
29MP0009046_muscle_twitch1.72568204
30MP0002572_abnormal_emotion/affect_behav1.68670054
31MP0002938_white_spotting1.66854560
32MP0002734_abnormal_mechanical_nocicepti1.61100588
33MP0001188_hyperpigmentation1.58421359
34MP0000350_abnormal_cell_proliferation1.54160681
35MP0002697_abnormal_eye_size1.53892484
36MP0002272_abnormal_nervous_system1.51445027
37MP0003937_abnormal_limbs/digits/tail_de1.48835959
38MP0000537_abnormal_urethra_morphology1.48545081
39MP0002234_abnormal_pharynx_morphology1.46393751
40MP0004233_abnormal_muscle_weight1.46376394
41MP0006276_abnormal_autonomic_nervous1.45543352
42MP0003122_maternal_imprinting1.44111143
43MP0006035_abnormal_mitochondrial_morpho1.40310542
44MP0001286_abnormal_eye_development1.39112881
45MP0002184_abnormal_innervation1.38546307
46MP0001697_abnormal_embryo_size1.37020362
47MP0010030_abnormal_orbit_morphology1.36951319
48MP0009672_abnormal_birth_weight1.36363227
49MP0002163_abnormal_gland_morphology1.30448464
50MP0002067_abnormal_sensory_capabilities1.21421366
51MP0003787_abnormal_imprinting1.20178875
52MP0004811_abnormal_neuron_physiology1.19595387
53MP0010352_gastrointestinal_tract_polyps1.19247306
54MP0003186_abnormal_redox_activity1.18593859
55MP0002733_abnormal_thermal_nociception1.17941446
56MP0001501_abnormal_sleep_pattern1.16535719
57MP0002233_abnormal_nose_morphology1.15567556
58MP0002080_prenatal_lethality1.14917837
59MP0008007_abnormal_cellular_replicative1.13646373
60MP0004924_abnormal_behavior1.13256669
61MP0005386_behavior/neurological_phenoty1.13256669
62MP0001346_abnormal_lacrimal_gland1.12504381
63MP0002084_abnormal_developmental_patter1.12250944
64MP0010234_abnormal_vibrissa_follicle1.11490743
65MP0003786_premature_aging1.11389061
66MP0010307_abnormal_tumor_latency1.10218910
67MP0001970_abnormal_pain_threshold1.09283155
68MP0005380_embryogenesis_phenotype1.08106627
69MP0001672_abnormal_embryogenesis/_devel1.08106627
70MP0003385_abnormal_body_wall1.05736456
71MP0000778_abnormal_nervous_system1.02524624
72MP0008995_early_reproductive_senescence1.01818654
73MP0002751_abnormal_autonomic_nervous1.01094613
74MP0001905_abnormal_dopamine_level1.00885243
75MP0000358_abnormal_cell_content/1.00752044
76MP0005623_abnormal_meninges_morphology0.99152500
77MP0003755_abnormal_palate_morphology0.97861275
78MP0006036_abnormal_mitochondrial_physio0.97777588
79MP0002085_abnormal_embryonic_tissue0.97380609
80MP0005499_abnormal_olfactory_system0.96607167
81MP0005394_taste/olfaction_phenotype0.96607167
82MP0002092_abnormal_eye_morphology0.96552500
83MP0002877_abnormal_melanocyte_morpholog0.94769920
84MP0003984_embryonic_growth_retardation0.94636203
85MP0003718_maternal_effect0.93321770
86MP0006072_abnormal_retinal_apoptosis0.93268595
87MP0002210_abnormal_sex_determination0.92587554
88MP0008872_abnormal_physiological_respon0.92136869
89MP0003119_abnormal_digestive_system0.91913431
90MP0002088_abnormal_embryonic_growth/wei0.91271406
91MP0000313_abnormal_cell_death0.89973581
92MP0008789_abnormal_olfactory_epithelium0.89317580
93MP0001486_abnormal_startle_reflex0.89021234
94MP0000566_synostosis0.88917873
95MP0005408_hypopigmentation0.88462493
96MP0002111_abnormal_tail_morphology0.88185891
97MP0000647_abnormal_sebaceous_gland0.87757192
98MP0003861_abnormal_nervous_system0.87283544
99MP0002160_abnormal_reproductive_system0.86833434
100MP0003221_abnormal_cardiomyocyte_apopto0.86412986
101MP0003942_abnormal_urinary_system0.86225436
102MP0004147_increased_porphyrin_level0.85150116
103MP0009703_decreased_birth_body0.84373183
104MP0002066_abnormal_motor_capabilities/c0.84070743
105MP0004197_abnormal_fetal_growth/weight/0.83757942
106MP0000049_abnormal_middle_ear0.83747862
107MP0004142_abnormal_muscle_tone0.83522765
108MP0005501_abnormal_skin_physiology0.82808394
109MP0004484_altered_response_of0.82167521
110MP0003806_abnormal_nucleotide_metabolis0.81904695
111MP0002152_abnormal_brain_morphology0.81770412
112MP0000579_abnormal_nail_morphology0.81735543
113MP0003890_abnormal_embryonic-extraembry0.80780939
114MP0002557_abnormal_social/conspecific_i0.80282856
115MP0001727_abnormal_embryo_implantation0.78456010
116MP0002090_abnormal_vision0.78292832
117MP0000955_abnormal_spinal_cord0.76917396
118MP0002086_abnormal_extraembryonic_tissu0.76731968
119MP0003315_abnormal_perineum_morphology0.76381380
120MP0002081_perinatal_lethality0.76034126
121MP0001145_abnormal_male_reproductive0.75460999
122MP0003935_abnormal_craniofacial_develop0.74854041
123MP0004215_abnormal_myocardial_fiber0.74704570
124MP0009053_abnormal_anal_canal0.74687423
125MP0005391_vision/eye_phenotype0.74020303
126MP0001929_abnormal_gametogenesis0.70997911
127MP0002882_abnormal_neuron_morphology0.70804542
128MP0002822_catalepsy0.69622622
129MP0000762_abnormal_tongue_morphology0.69398271
130MP0000631_abnormal_neuroendocrine_gland0.67942728
131MP0004145_abnormal_muscle_electrophysio0.67705978
132MP0000653_abnormal_sex_gland0.67311836
133MP0009697_abnormal_copulation0.67062534
134MP0001984_abnormal_olfaction0.64473814
135MP0003938_abnormal_ear_development0.63069631
136MP0003183_abnormal_peptide_metabolism0.62901851
137MP0003567_abnormal_fetal_cardiomyocyte0.62650378
138MP0008770_decreased_survivor_rate0.62451140
139MP0005384_cellular_phenotype0.60354196
140MP0001299_abnormal_eye_distance/0.59672783
141MP0005187_abnormal_penis_morphology0.58138453
142MP0000747_muscle_weakness0.57919290

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.07511955
2Acute necrotizing encephalopathy (HP:0006965)3.98383452
3Birth length less than 3rd percentile (HP:0003561)3.84952589
4Abnormality of the labia minora (HP:0012880)3.80242533
5Increased serum pyruvate (HP:0003542)3.68996284
6Abnormality of glycolysis (HP:0004366)3.68996284
7Abnormal mitochondria in muscle tissue (HP:0008316)3.63172276
8Chromsome breakage (HP:0040012)3.60003132
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.53432260
10Progressive macrocephaly (HP:0004481)3.46493652
11Cortical dysplasia (HP:0002539)3.36441192
12Atonic seizures (HP:0010819)3.33340260
13Increased CSF lactate (HP:0002490)3.25342366
14Mitochondrial inheritance (HP:0001427)3.25022115
15Shoulder girdle muscle weakness (HP:0003547)3.16611086
16Abnormality of cells of the erythroid lineage (HP:0012130)3.07910084
17Acute encephalopathy (HP:0006846)2.96810083
18Absence seizures (HP:0002121)2.93178685
19Multiple enchondromatosis (HP:0005701)2.92380005
20Breast hypoplasia (HP:0003187)2.83284693
21Epileptic encephalopathy (HP:0200134)2.80601630
22Cerebral hypomyelination (HP:0006808)2.79097224
23Carpal bone hypoplasia (HP:0001498)2.74660769
24Reticulocytopenia (HP:0001896)2.72932942
25Meckel diverticulum (HP:0002245)2.72576161
26Macrocytic anemia (HP:0001972)2.71871434
27Increased hepatocellular lipid droplets (HP:0006565)2.71526170
28Visual hallucinations (HP:0002367)2.66940639
29Oral leukoplakia (HP:0002745)2.65273663
30Focal seizures (HP:0007359)2.63673302
31Abnormal number of erythroid precursors (HP:0012131)2.60116144
32Hyperalaninemia (HP:0003348)2.59732444
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59732444
34Abnormality of alanine metabolism (HP:0010916)2.59732444
35Pelvic girdle muscle weakness (HP:0003749)2.58093803
36Hepatocellular necrosis (HP:0001404)2.58051350
37Increased nuchal translucency (HP:0010880)2.57262654
38Delusions (HP:0000746)2.56849240
39Postnatal microcephaly (HP:0005484)2.55815474
40Abnormality of the ileum (HP:0001549)2.54272117
41Nephroblastoma (Wilms tumor) (HP:0002667)2.53668302
42Dialeptic seizures (HP:0011146)2.47963483
43Abnormality of the preputium (HP:0100587)2.46572781
44Myokymia (HP:0002411)2.46172276
45Abnormal lung lobation (HP:0002101)2.43643060
46Emotional lability (HP:0000712)2.42855843
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.40766085
48Increased serum lactate (HP:0002151)2.39498336
49Abnormality of chromosome stability (HP:0003220)2.37790305
50Abnormality of the musculature of the pelvis (HP:0001469)2.37442514
51Abnormality of the hip-girdle musculature (HP:0001445)2.37442514
52Embryonal renal neoplasm (HP:0011794)2.35912667
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29803661
54Colon cancer (HP:0003003)2.29020556
55Exercise intolerance (HP:0003546)2.23377256
56Glossoptosis (HP:0000162)2.23110245
57Hyperventilation (HP:0002883)2.21980639
58Pallor (HP:0000980)2.18934833
59Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.17718189
60Volvulus (HP:0002580)2.17298643
61Agnosia (HP:0010524)2.13823658
62Abnormality of methionine metabolism (HP:0010901)2.12847291
63Small intestinal stenosis (HP:0012848)2.11246506
64Duodenal stenosis (HP:0100867)2.11246506
65Lipid accumulation in hepatocytes (HP:0006561)2.10411610
66Medulloblastoma (HP:0002885)2.09670145
67Respiratory failure (HP:0002878)2.09649236
68Rough bone trabeculation (HP:0100670)2.08734524
69Hyperglycinemia (HP:0002154)2.07816220
70Unsteady gait (HP:0002317)2.04151750
71Horseshoe kidney (HP:0000085)2.02906401
72Neuroblastoma (HP:0003006)1.98919878
73Primitive neuroectodermal tumor (HP:0030065)1.98919878
74Neuroblastic tumors (HP:0004376)1.98919878
75Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.98919878
76Irregular epiphyses (HP:0010582)1.98530132
77Cerebral edema (HP:0002181)1.98470551
78Myelodysplasia (HP:0002863)1.97794190
79Triphalangeal thumb (HP:0001199)1.97300565
80Hyperthyroidism (HP:0000836)1.96541523
81CNS hypomyelination (HP:0003429)1.96490215
82Leukodystrophy (HP:0002415)1.94314790
83Rhabdomyosarcoma (HP:0002859)1.93321865
84Testicular atrophy (HP:0000029)1.93066991
85Lactic acidosis (HP:0003128)1.91846593
86Termporal pattern (HP:0011008)1.88588422
87Insidious onset (HP:0003587)1.88588422
88Overlapping toe (HP:0001845)1.88023463
89Exercise-induced muscle cramps (HP:0003710)1.87903181
90Angiofibromas (HP:0010615)1.87757878
91Adenoma sebaceum (HP:0009720)1.87757878
92Atrophy/Degeneration involving motor neurons (HP:0007373)1.87570255
93Hydroureter (HP:0000072)1.87483592
94Absent thumb (HP:0009777)1.84790060
95Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84532097
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84438995
97Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84438995
98Respiratory difficulties (HP:0002880)1.84152279
99Neoplasm of the peripheral nervous system (HP:0100007)1.83809557
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83146468
101Hypoplastic pelvis (HP:0008839)1.82329526
102Microvesicular hepatic steatosis (HP:0001414)1.81807034
103Neoplasm of the colon (HP:0100273)1.81589309
104Trismus (HP:0000211)1.80695625
105Abnormality of the duodenum (HP:0002246)1.79888902
106Hypoplasia of the pons (HP:0012110)1.79789400
107Progressive cerebellar ataxia (HP:0002073)1.78878323
108Amblyopia (HP:0000646)1.78713953
109Abnormality of the carotid arteries (HP:0005344)1.77941111
110Optic disc pallor (HP:0000543)1.77490430
111Abnormality of reticulocytes (HP:0004312)1.77251427
112Cholecystitis (HP:0001082)1.76429961
113Abnormal gallbladder physiology (HP:0012438)1.76429961
114Progressive external ophthalmoplegia (HP:0000590)1.76136052
115Hypoglycemic coma (HP:0001325)1.74915532
116Abnormality of the anterior horn cell (HP:0006802)1.74447402
117Degeneration of anterior horn cells (HP:0002398)1.74447402
118Amyotrophic lateral sclerosis (HP:0007354)1.74365274
119Facial hemangioma (HP:0000329)1.74293970
120Facial cleft (HP:0002006)1.72096018
121X-linked dominant inheritance (HP:0001423)1.71934175
122Febrile seizures (HP:0002373)1.71920679
123Absent radius (HP:0003974)1.70987320
124Abnormality of serum amino acid levels (HP:0003112)1.69987280
125Resting tremor (HP:0002322)1.69605528
126Poor eye contact (HP:0000817)1.69284988
127Patellar aplasia (HP:0006443)1.68826555
128Generalized tonic-clonic seizures (HP:0002069)1.68240537
129Gout (HP:0001997)1.66053681
130Embryonal neoplasm (HP:0002898)1.65826090
131Premature ovarian failure (HP:0008209)1.65509052
132Broad-based gait (HP:0002136)1.65502763
133Hepatic necrosis (HP:0002605)1.65419498
134Absent forearm bone (HP:0003953)1.63845146
135Aplasia involving forearm bones (HP:0009822)1.63845146
136Pancreatic islet-cell hyperplasia (HP:0004510)1.63544297
137Sloping forehead (HP:0000340)1.63014437
138Hepatoblastoma (HP:0002884)1.62213249
139Ependymoma (HP:0002888)1.62200990
140Renal Fanconi syndrome (HP:0001994)1.61797842
141Hyperinsulinemic hypoglycemia (HP:0000825)1.60894339
142Proximal placement of thumb (HP:0009623)1.60508890
143Stenosis of the external auditory canal (HP:0000402)1.59793000
144Aplastic anemia (HP:0001915)1.58458015
145Megaloblastic anemia (HP:0001889)1.55636730
146Abnormality of placental membranes (HP:0011409)1.55106820
147Amniotic constriction ring (HP:0009775)1.55106820
148Abnormality of cochlea (HP:0000375)1.53925283
149Missing ribs (HP:0000921)1.52297276
150Insomnia (HP:0100785)1.51337223
151Choanal atresia (HP:0000453)1.49437332
152Deviation of the thumb (HP:0009603)1.45938153

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.13644659
2EIF2AK13.09578304
3TSSK63.03032416
4PNCK2.97733600
5MAP3K122.87463514
6BUB12.83857488
7WEE12.77388769
8VRK22.58490470
9NEK12.46938314
10PLK22.37317726
11NME22.33341017
12NME12.27917730
13NTRK32.16584220
14EPHA42.08759581
15PLK32.05282726
16TRIM281.93067063
17MAP3K41.89946052
18CASK1.89433615
19MINK11.88484309
20CCNB11.87318823
21TAF11.73971574
22SCYL21.67753588
23CDK191.65989177
24TLK11.61408340
25MKNK11.57199659
26MAP2K71.56985282
27MAP3K91.56497097
28DAPK11.51376950
29MKNK21.50351932
30SRPK11.48637373
31EIF2AK31.42912946
32RIPK41.40063408
33ARAF1.26782055
34STK161.25698816
35MAP2K41.23797483
36LATS21.23352613
37PLK11.23331769
38PDK31.23092964
39PDK41.23092964
40VRK11.19149987
41AKT31.18262454
42TNIK1.14142550
43KSR11.11504536
44ERBB31.11354313
45ACVR1B1.11071544
46ZAK1.08809190
47RPS6KA41.06206595
48TTK1.05365527
49CDK141.04295610
50BRSK21.01578039
51ALK0.98139959
52BRAF0.97589042
53AURKA0.96823279
54CSNK1G30.94854642
55CSNK1A1L0.94740381
56GRK50.92313759
57DYRK20.91083746
58CDK180.90493322
59DYRK30.89178928
60CDK80.88579363
61PBK0.86739202
62CDK150.86375376
63EIF2AK20.86260505
64NEK20.85182835
65AURKB0.84548885
66CSNK1G20.84175477
67STK38L0.81692335
68BRSK10.81488694
69CSNK1G10.81237909
70RAF10.80573918
71PRKCG0.80013812
72WNK30.79293265
73CDK11A0.78924287
74BRD40.78276633
75LIMK10.77033507
76PLK40.76953507
77LATS10.76441449
78ERBB40.76148409
79BCR0.74613214
80CSNK2A20.72539372
81RPS6KB20.72435588
82NUAK10.72017799
83WNK40.70518567
84STK30.68875598
85CHEK20.68220381
86FER0.67968978
87CSNK1E0.65871776
88MST40.65285697
89ATR0.65274344
90KSR20.64754904
91CHEK10.64504368
92TESK20.63586929
93EEF2K0.62036947
94FGFR10.61764347
95STK390.61447117
96PAK40.60815906
97BMPR20.59942503
98GRK60.58944036
99PTK2B0.54899510
100STK240.54687621
101PASK0.54095378
102PRKCI0.53394114
103CDK70.50805251
104MST1R0.50792743
105SIK30.49651995
106PAK10.49578180
107CDK50.48243659
108CSNK2A10.47897755
109ILK0.47346779
110MAPKAPK50.46920862
111CDK20.46521543
112MARK10.44887258
113MET0.44775463
114PDK20.44473706
115MAP3K80.44321929
116CAMK2B0.43764185
117ATM0.43498413
118PRKDC0.43445620
119SMG10.42558003
120CAMK2A0.42495703
121CAMKK20.40644852
122MAP3K50.40383597
123NTRK10.40150820
124FLT30.38959898
125CDK10.38526760
126PAK60.38440386
127DYRK1A0.38347803
128RPS6KB10.37832244
129TESK10.37277445
130BCKDK0.36072397
131ADRBK10.35954696
132ROCK20.35827679
133CDK120.35483352
134DAPK30.34940524
135PKN20.34878353
136FGR0.34857680

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.87648072
2Proteasome_Homo sapiens_hsa030503.78281818
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.37255992
4RNA polymerase_Homo sapiens_hsa030202.97413276
5DNA replication_Homo sapiens_hsa030302.84540154
6Oxidative phosphorylation_Homo sapiens_hsa001902.83360888
7RNA transport_Homo sapiens_hsa030132.73518371
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.58793726
9Spliceosome_Homo sapiens_hsa030402.53242456
10Mismatch repair_Homo sapiens_hsa034302.51992992
11Parkinsons disease_Homo sapiens_hsa050122.46654581
12Nicotine addiction_Homo sapiens_hsa050332.43725807
13Nucleotide excision repair_Homo sapiens_hsa034202.11989937
14Huntingtons disease_Homo sapiens_hsa050162.00845572
15Alzheimers disease_Homo sapiens_hsa050101.93156223
16Long-term potentiation_Homo sapiens_hsa047201.90408870
17Oocyte meiosis_Homo sapiens_hsa041141.82687283
18Synaptic vesicle cycle_Homo sapiens_hsa047211.82533211
19Cell cycle_Homo sapiens_hsa041101.72403510
20Pyrimidine metabolism_Homo sapiens_hsa002401.68607854
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63051963
22Homologous recombination_Homo sapiens_hsa034401.62441351
23Collecting duct acid secretion_Homo sapiens_hsa049661.57230650
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52643553
25Amphetamine addiction_Homo sapiens_hsa050311.43359343
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42026225
27One carbon pool by folate_Homo sapiens_hsa006701.41004916
28Propanoate metabolism_Homo sapiens_hsa006401.40165633
29Steroid biosynthesis_Homo sapiens_hsa001001.38974481
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.34160749
31RNA degradation_Homo sapiens_hsa030181.30692690
32mRNA surveillance pathway_Homo sapiens_hsa030151.29040662
33Dopaminergic synapse_Homo sapiens_hsa047281.25833010
34Fatty acid elongation_Homo sapiens_hsa000621.20825914
35Vibrio cholerae infection_Homo sapiens_hsa051101.17076072
36Basal transcription factors_Homo sapiens_hsa030221.14036166
37Non-homologous end-joining_Homo sapiens_hsa034501.12718547
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12488417
39Cardiac muscle contraction_Homo sapiens_hsa042601.09281401
40Base excision repair_Homo sapiens_hsa034101.09049935
41Long-term depression_Homo sapiens_hsa047301.08732082
42Purine metabolism_Homo sapiens_hsa002301.05922434
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03545445
44GABAergic synapse_Homo sapiens_hsa047271.02432143
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01674871
46Circadian entrainment_Homo sapiens_hsa047130.97334668
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97074163
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97071013
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93138823
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93015401
51Glutamatergic synapse_Homo sapiens_hsa047240.91757363
52Morphine addiction_Homo sapiens_hsa050320.90633545
53Alcoholism_Homo sapiens_hsa050340.89022976
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87841229
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85902242
56Folate biosynthesis_Homo sapiens_hsa007900.85382296
57Olfactory transduction_Homo sapiens_hsa047400.84744579
58Selenocompound metabolism_Homo sapiens_hsa004500.84543846
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.83844964
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.81434820
61Taste transduction_Homo sapiens_hsa047420.80600977
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79770224
63Serotonergic synapse_Homo sapiens_hsa047260.79230639
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78601104
65Arginine and proline metabolism_Homo sapiens_hsa003300.78285386
66Fanconi anemia pathway_Homo sapiens_hsa034600.78257708
67Biosynthesis of amino acids_Homo sapiens_hsa012300.77211346
68Vitamin B6 metabolism_Homo sapiens_hsa007500.77002638
69Epstein-Barr virus infection_Homo sapiens_hsa051690.76486884
70Glutathione metabolism_Homo sapiens_hsa004800.74641253
71Salivary secretion_Homo sapiens_hsa049700.72820461
72Gap junction_Homo sapiens_hsa045400.70467473
73p53 signaling pathway_Homo sapiens_hsa041150.69484361
74Systemic lupus erythematosus_Homo sapiens_hsa053220.69360251
75Fatty acid metabolism_Homo sapiens_hsa012120.67289691
76Oxytocin signaling pathway_Homo sapiens_hsa049210.67288215
77Renin secretion_Homo sapiens_hsa049240.66578132
78Protein export_Homo sapiens_hsa030600.62922119
79Glioma_Homo sapiens_hsa052140.62683623
80Thyroid cancer_Homo sapiens_hsa052160.62653767
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61568212
82Carbon metabolism_Homo sapiens_hsa012000.61370907
83Metabolic pathways_Homo sapiens_hsa011000.59213697
84Calcium signaling pathway_Homo sapiens_hsa040200.56552001
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56439642
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54104302
87Sulfur relay system_Homo sapiens_hsa041220.53810698
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53761176
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53392358
90Cholinergic synapse_Homo sapiens_hsa047250.53305655
91Arginine biosynthesis_Homo sapiens_hsa002200.50088048
92N-Glycan biosynthesis_Homo sapiens_hsa005100.49869353
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49836081
94Butanoate metabolism_Homo sapiens_hsa006500.49542369
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49493220
96Fructose and mannose metabolism_Homo sapiens_hsa000510.48817750
97Gastric acid secretion_Homo sapiens_hsa049710.47822379
98Adherens junction_Homo sapiens_hsa045200.47541379
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46811586
100Estrogen signaling pathway_Homo sapiens_hsa049150.46204492
101Melanogenesis_Homo sapiens_hsa049160.45496610
102GnRH signaling pathway_Homo sapiens_hsa049120.45218134
103Pyruvate metabolism_Homo sapiens_hsa006200.44416713
104Basal cell carcinoma_Homo sapiens_hsa052170.43607431
105Viral carcinogenesis_Homo sapiens_hsa052030.42478449
106Melanoma_Homo sapiens_hsa052180.40946268
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40156930
108Lysine degradation_Homo sapiens_hsa003100.39350370
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39240715
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37082456
111Colorectal cancer_Homo sapiens_hsa052100.36631507
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35867436
113Wnt signaling pathway_Homo sapiens_hsa043100.34884796
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33770396
115Hedgehog signaling pathway_Homo sapiens_hsa043400.33482384
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.33229269
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31467589
118Tight junction_Homo sapiens_hsa045300.29488301
119ErbB signaling pathway_Homo sapiens_hsa040120.28564143
120HIF-1 signaling pathway_Homo sapiens_hsa040660.28522093
121Peroxisome_Homo sapiens_hsa041460.28111596
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27559105
123Galactose metabolism_Homo sapiens_hsa000520.26677362
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24900225
125beta-Alanine metabolism_Homo sapiens_hsa004100.24572637
126Cocaine addiction_Homo sapiens_hsa050300.24353394
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23776002
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.23640348
129Fatty acid biosynthesis_Homo sapiens_hsa000610.23562174
130Type I diabetes mellitus_Homo sapiens_hsa049400.23494808
131mTOR signaling pathway_Homo sapiens_hsa041500.23222536
132Hippo signaling pathway_Homo sapiens_hsa043900.23211539
133Glucagon signaling pathway_Homo sapiens_hsa049220.23077361
134Fatty acid degradation_Homo sapiens_hsa000710.22479246
135Insulin secretion_Homo sapiens_hsa049110.22355605
136Pentose phosphate pathway_Homo sapiens_hsa000300.21623466
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20385318
138VEGF signaling pathway_Homo sapiens_hsa043700.20202387
139Starch and sucrose metabolism_Homo sapiens_hsa005000.19702011
140TGF-beta signaling pathway_Homo sapiens_hsa043500.19355501
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18812469
142Vitamin digestion and absorption_Homo sapiens_hsa049770.15367334
143Sulfur metabolism_Homo sapiens_hsa009200.14635579
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.13075751

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