ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	rRNA modification (GO:0000154)	4.61410657
2	proteasome assembly (GO:0043248)	4.57619297
3	DNA double-strand break processing (GO:0000729)	4.44967190
4	rRNA methylation (GO:0031167)	4.14007105
5	motile cilium assembly (GO:0044458)	4.11172549
6	chaperone-mediated protein transport (GO:0072321)	3.88847424
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.72454178
8	protein neddylation (GO:0045116)	3.72031384
9	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.71459720
10	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.68582936
11	DNA deamination (GO:0045006)	3.67523100
12	positive regulation of granulocyte differentiation (GO:0030854)	3.65892010
13	water-soluble vitamin biosynthetic process (GO:0042364)	3.52799257
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.46449716
15	ATP synthesis coupled proton transport (GO:0015986)	3.46449716
16	termination of RNA polymerase III transcription (GO:0006386)	3.42911412
17	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.42911412
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.38986974
19	platelet dense granule organization (GO:0060155)	3.33797959
20	prenylation (GO:0097354)	3.33708415
21	protein prenylation (GO:0018342)	3.33708415
22	cullin deneddylation (GO:0010388)	3.27127426
23	DNA replication-dependent nucleosome organization (GO:0034723)	3.26532503
24	DNA replication-dependent nucleosome assembly (GO:0006335)	3.26532503
25	protein K6-linked ubiquitination (GO:0085020)	3.26405714
26	dentate gyrus development (GO:0021542)	3.19780130
27	pseudouridine synthesis (GO:0001522)	3.17522165
28	adenosine metabolic process (GO:0046085)	3.14717791
29	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.13332073
30	ubiquinone metabolic process (GO:0006743)	3.10965584
31	ribonucleoprotein complex disassembly (GO:0032988)	3.09438270
32	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.09289811
33	chromatin remodeling at centromere (GO:0031055)	3.07424413
34	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	3.02239754
35	ubiquinone biosynthetic process (GO:0006744)	3.00785201
36	inositol phosphate catabolic process (GO:0071545)	2.99897624
37	regulation of isotype switching to IgG isotypes (GO:0048302)	2.94805053
38	postreplication repair (GO:0006301)	2.94479665
39	DNA catabolic process, exonucleolytic (GO:0000738)	2.92845939
40	respiratory electron transport chain (GO:0022904)	2.91283094
41	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.89805442
42	protein-cofactor linkage (GO:0018065)	2.88055273
43	protein deneddylation (GO:0000338)	2.87106472
44	electron transport chain (GO:0022900)	2.86485955
45	viral mRNA export from host cell nucleus (GO:0046784)	2.84753461
46	replication fork processing (GO:0031297)	2.84185869
47	mitochondrial RNA metabolic process (GO:0000959)	2.82753209
48	CENP-A containing nucleosome assembly (GO:0034080)	2.82494727
49	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.80435891
50	inositol phosphate dephosphorylation (GO:0046855)	2.80435891
51	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.79314664
52	DNA replication checkpoint (GO:0000076)	2.79149991
53	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.78330097
54	peptidyl-histidine modification (GO:0018202)	2.78247619
55	DNA ligation (GO:0006266)	2.77933858
56	protein K11-linked ubiquitination (GO:0070979)	2.76707674
57	negative regulation of membrane potential (GO:0045837)	2.76120156
58	histone mRNA metabolic process (GO:0008334)	2.74256228
59	signal peptide processing (GO:0006465)	2.72057878
60	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.70772869
61	ribosome assembly (GO:0042255)	2.69518078
62	kinetochore assembly (GO:0051382)	2.69348827
63	recombinational repair (GO:0000725)	2.69312962
64	regulation of mitochondrial translation (GO:0070129)	2.68507674
65	tRNA methylation (GO:0030488)	2.68377705
66	maturation of 5.8S rRNA (GO:0000460)	2.67928922
67	regulation of cellular amino acid metabolic process (GO:0006521)	2.67928618
68	DNA damage response, detection of DNA damage (GO:0042769)	2.65699766
69	rRNA catabolic process (GO:0016075)	2.65062882
70	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.64008031
71	negative regulation of T-helper cell differentiation (GO:0045623)	2.64008031
72	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.63472412
73	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.63472412
74	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.63472412
75	double-strand break repair via homologous recombination (GO:0000724)	2.62465834
76	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.61206989
77	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.61206989
78	centriole assembly (GO:0098534)	2.60934426
79	termination of RNA polymerase I transcription (GO:0006363)	2.59105939
80	histone H2A acetylation (GO:0043968)	2.59044946
81	negative regulation of telomere maintenance (GO:0032205)	2.57607459
82	regulation of chronic inflammatory response (GO:0002676)	2.57394968
83	negative regulation of DNA recombination (GO:0045910)	2.57146156
84	aldehyde catabolic process (GO:0046185)	2.55176339
85	opioid receptor signaling pathway (GO:0038003)	2.54485392
86	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.53609989
87	organelle disassembly (GO:1903008)	2.52550685
88	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.51741639
89	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.51741639
90	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.50786399
91	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	2.50737277
92	T-helper cell differentiation (GO:0042093)	2.50737277
93	protein localization to synapse (GO:0035418)	2.49490319
94	magnesium ion transport (GO:0015693)	2.48297754
95	cellular ketone body metabolic process (GO:0046950)	2.47008765
96	ether lipid metabolic process (GO:0046485)	2.45678704
97	glycerol ether metabolic process (GO:0006662)	2.44667337
98	quinone biosynthetic process (GO:1901663)	2.44511968
99	sequestering of actin monomers (GO:0042989)	2.44302353
100	cytokine biosynthetic process (GO:0042089)	2.43868436

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.96907769
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.55065242
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.54622124
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.14551005
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.05508658
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82067491
7	FUS_26573619_Chip-Seq_HEK293_Human	2.59241454
8	EWS_26573619_Chip-Seq_HEK293_Human	2.53898758
9	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.53601627
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.49611810
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.42908752
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.40879655
13	VDR_22108803_ChIP-Seq_LS180_Human	2.31527651
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.30177644
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.25731506
16	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.23457022
17	E2F7_22180533_ChIP-Seq_HELA_Human	2.22116869
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.19903358
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.17591489
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.12604518
21	ELK1_19687146_ChIP-ChIP_HELA_Human	2.09586892
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.08993866
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.08427760
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07637386
25	TAF15_26573619_Chip-Seq_HEK293_Human	2.04930313
26	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.95366886
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.84788417
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.78620987
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.72015411
30	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.70441876
31	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.69557667
32	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.69128983
33	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.67416818
34	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.62839113
35	P300_19829295_ChIP-Seq_ESCs_Human	1.54628733
36	GBX2_23144817_ChIP-Seq_PC3_Human	1.53899941
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.51085979
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49463799
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.49005394
40	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48308977
41	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.47954242
42	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.47439046
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.47342397
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47342397
45	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.45915425
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.45288633
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.41730378
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.40763120
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.36563360
50	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35740558
51	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34946995
52	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.34923417
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.31861972
54	AR_20517297_ChIP-Seq_VCAP_Human	1.29225024
55	DCP1A_22483619_ChIP-Seq_HELA_Human	1.29122600
56	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.27436216
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.26742431
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25297674
59	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25297674
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24669315
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24669315
62	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23287639
63	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.21251003
64	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.19296309
65	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.17893754
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17560920
67	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.17374381
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16705481
69	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.14794138
70	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.12545010
71	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.11968620
72	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.11543813
73	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.11408965
74	NCOR_22424771_ChIP-Seq_293T_Human	1.11376435
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09892859
76	TTF2_22483619_ChIP-Seq_HELA_Human	1.08769053
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06431403
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05427588
79	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.04603310
80	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.02452393
81	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.02156779
82	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.02125330
83	ERG_20517297_ChIP-Seq_VCAP_Human	0.97660034
84	TCF4_22108803_ChIP-Seq_LS180_Human	0.96694687
85	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.95910330
86	HTT_18923047_ChIP-ChIP_STHdh_Human	0.95328895
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94992788
88	TCF4_23295773_ChIP-Seq_U87_Human	0.93415206
89	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.93138000
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92973763
91	AR_25329375_ChIP-Seq_VCAP_Human	0.92661216
92	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.92190512
93	STAT3_23295773_ChIP-Seq_U87_Human	0.89004065
94	BCAT_22108803_ChIP-Seq_LS180_Human	0.88811726
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87854424
96	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.87789026
97	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.87658245
98	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.87237499
99	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.86684523
100	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.86449202

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	5.92119580
2	MP0001529_abnormal_vocalization	3.35483936
3	MP0006072_abnormal_retinal_apoptosis	2.87655356
4	MP0008872_abnormal_physiological_respon	2.60475768
5	MP0008877_abnormal_DNA_methylation	2.51115348
6	MP0003787_abnormal_imprinting	2.46363645
7	MP0006292_abnormal_olfactory_placode	2.45817079
8	MP0001188_hyperpigmentation	2.42145663
9	MP0003693_abnormal_embryo_hatching	2.33744800
10	MP0008789_abnormal_olfactory_epithelium	2.31851241
11	MP0001348_abnormal_lacrimal_gland	2.14037092
12	MP0009697_abnormal_copulation	1.99569358
13	MP0002837_dystrophic_cardiac_calcinosis	1.98913517
14	MP0001986_abnormal_taste_sensitivity	1.94969735
15	MP0005085_abnormal_gallbladder_physiolo	1.89727420
16	MP0008875_abnormal_xenobiotic_pharmacok	1.78215534
17	MP0002102_abnormal_ear_morphology	1.73846829
18	MP0005551_abnormal_eye_electrophysiolog	1.71659198
19	MP0002735_abnormal_chemical_nociception	1.67206827
20	MP0003786_premature_aging	1.61002971
21	MP0001984_abnormal_olfaction	1.60960356
22	MP0005394_taste/olfaction_phenotype	1.57867155
23	MP0005499_abnormal_olfactory_system	1.57867155
24	MP0005253_abnormal_eye_physiology	1.56230982
25	MP0002160_abnormal_reproductive_system	1.52412901
26	MP0003880_abnormal_central_pattern	1.52223301
27	MP0002638_abnormal_pupillary_reflex	1.50753978
28	MP0003121_genomic_imprinting	1.49284324
29	MP0001873_stomach_inflammation	1.48856818
30	MP0004142_abnormal_muscle_tone	1.46935351
31	MP0010386_abnormal_urinary_bladder	1.46198642
32	MP0004957_abnormal_blastocyst_morpholog	1.45498438
33	MP0001293_anophthalmia	1.43416257
34	MP0010094_abnormal_chromosome_stability	1.42504196
35	MP0005645_abnormal_hypothalamus_physiol	1.39115008
36	MP0002272_abnormal_nervous_system	1.38573920
37	MP0005084_abnormal_gallbladder_morpholo	1.38415095
38	MP0003718_maternal_effect	1.34983187
39	MP0008058_abnormal_DNA_repair	1.33715106
40	MP0002184_abnormal_innervation	1.32135073
41	MP0009745_abnormal_behavioral_response	1.31443103
42	MP0001905_abnormal_dopamine_level	1.28307547
43	MP0005389_reproductive_system_phenotype	1.27855910
44	MP0000427_abnormal_hair_cycle	1.27702769
45	MP0008057_abnormal_DNA_replication	1.26810019
46	MP0004145_abnormal_muscle_electrophysio	1.26486103
47	MP0001968_abnormal_touch/_nociception	1.24924949
48	MP0006036_abnormal_mitochondrial_physio	1.19868174
49	MP0004742_abnormal_vestibular_system	1.18966321
50	MP0005386_behavior/neurological_phenoty	1.13856066
51	MP0004924_abnormal_behavior	1.13856066
52	MP0009046_muscle_twitch	1.13084859
53	MP0006276_abnormal_autonomic_nervous	1.11416247
54	MP0001486_abnormal_startle_reflex	1.11134793
55	MP0002736_abnormal_nociception_after	1.09614346
56	MP0000372_irregular_coat_pigmentation	1.08401426
57	MP0002557_abnormal_social/conspecific_i	1.07902069
58	MP0004885_abnormal_endolymph	1.06786603
59	MP0001879_abnormal_lymphatic_vessel	1.06580277
60	MP0000013_abnormal_adipose_tissue	1.04916965
61	MP0002751_abnormal_autonomic_nervous	1.04856423
62	MP0000778_abnormal_nervous_system	1.04586603
63	MP0001919_abnormal_reproductive_system	1.02952787
64	MP0003011_delayed_dark_adaptation	1.02178939
65	MP0004270_analgesia	1.01237609
66	MP0001286_abnormal_eye_development	0.98362048
67	MP0004084_abnormal_cardiac_muscle	0.95413253
68	MP0003635_abnormal_synaptic_transmissio	0.94649251
69	MP0006035_abnormal_mitochondrial_morpho	0.93978109
70	MP0002734_abnormal_mechanical_nocicepti	0.93874924
71	MP0002277_abnormal_respiratory_mucosa	0.92637968
72	MP0002752_abnormal_somatic_nervous	0.89296270
73	MP0001970_abnormal_pain_threshold	0.87995747
74	MP0003119_abnormal_digestive_system	0.87679504
75	MP0003806_abnormal_nucleotide_metabolis	0.86910008
76	MP0002733_abnormal_thermal_nociception	0.85392495
77	MP0002653_abnormal_ependyma_morphology	0.84849534
78	MP0003077_abnormal_cell_cycle	0.83945374
79	MP0001664_abnormal_digestion	0.83537174
80	MP0001485_abnormal_pinna_reflex	0.83334990
81	MP0005220_abnormal_exocrine_pancreas	0.82912520
82	MP0003186_abnormal_redox_activity	0.82898208
83	MP0005195_abnormal_posterior_eye	0.82875008
84	MP0003890_abnormal_embryonic-extraembry	0.81182050
85	MP0001764_abnormal_homeostasis	0.81106096
86	MP0001177_atelectasis	0.80661659
87	MP0004215_abnormal_myocardial_fiber	0.80049408
88	MP0008775_abnormal_heart_ventricle	0.77774531
89	MP0003937_abnormal_limbs/digits/tail_de	0.77705348
90	MP0000631_abnormal_neuroendocrine_gland	0.77557208
91	MP0005379_endocrine/exocrine_gland_phen	0.76682917
92	MP0005377_hearing/vestibular/ear_phenot	0.76363966
93	MP0003878_abnormal_ear_physiology	0.76363966
94	MP0003111_abnormal_nucleus_morphology	0.75557642
95	MP0003195_calcinosis	0.74043203
96	MP0002572_abnormal_emotion/affect_behav	0.73933646
97	MP0002067_abnormal_sensory_capabilities	0.72831582
98	MP0004185_abnormal_adipocyte_glucose	0.71371976
99	MP0000955_abnormal_spinal_cord	0.68048492
100	MP0009379_abnormal_foot_pigmentation	0.67996033

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.54996862
2	Progressive macrocephaly (HP:0004481)	3.12966676
3	Acute encephalopathy (HP:0006846)	3.10381578
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.09091545
5	Pendular nystagmus (HP:0012043)	3.00573519
6	Mitochondrial inheritance (HP:0001427)	2.95191608
7	Pancreatic cysts (HP:0001737)	2.87958115
8	Pancreatic fibrosis (HP:0100732)	2.82973235
9	Type 2 muscle fiber atrophy (HP:0003554)	2.80902097
10	Increased CSF lactate (HP:0002490)	2.78975868
11	Decreased central vision (HP:0007663)	2.74223643
12	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.71046184
13	Hepatic necrosis (HP:0002605)	2.69861260
14	Meckel diverticulum (HP:0002245)	2.66552131
15	Molar tooth sign on MRI (HP:0002419)	2.66405172
16	Abnormality of midbrain morphology (HP:0002418)	2.66405172
17	Hepatocellular necrosis (HP:0001404)	2.62910710
18	Abnormality of the ileum (HP:0001549)	2.55527003
19	True hermaphroditism (HP:0010459)	2.52760048
20	Muscle fiber atrophy (HP:0100295)	2.50995212
21	Oligodactyly (hands) (HP:0001180)	2.49985711
22	Hyperglycinemia (HP:0002154)	2.47714403
23	Colon cancer (HP:0003003)	2.46171786
24	Abnormality of chromosome stability (HP:0003220)	2.45118170
25	Increased serum lactate (HP:0002151)	2.44762962
26	Medial flaring of the eyebrow (HP:0010747)	2.42689391
27	Hypoplasia of the uterus (HP:0000013)	2.42612970
28	Cerebral edema (HP:0002181)	2.41166436
29	Cutaneous melanoma (HP:0012056)	2.39406150
30	Horseshoe kidney (HP:0000085)	2.38887479
31	3-Methylglutaconic aciduria (HP:0003535)	2.38609453
32	Stenosis of the external auditory canal (HP:0000402)	2.35010404
33	Abolished electroretinogram (ERG) (HP:0000550)	2.34968012
34	Neuroendocrine neoplasm (HP:0100634)	2.32583555
35	Small intestinal stenosis (HP:0012848)	2.32380431
36	Duodenal stenosis (HP:0100867)	2.32380431
37	Nephrogenic diabetes insipidus (HP:0009806)	2.31681103
38	Aplasia/hypoplasia of the uterus (HP:0008684)	2.27601751
39	Increased corneal curvature (HP:0100692)	2.27220876
40	Keratoconus (HP:0000563)	2.27220876
41	Sclerocornea (HP:0000647)	2.25770406
42	Nephronophthisis (HP:0000090)	2.25616437
43	Squamous cell carcinoma (HP:0002860)	2.25117284
44	Clubbing of toes (HP:0100760)	2.21716839
45	Hyperglycinuria (HP:0003108)	2.21605730
46	Abnormality of alanine metabolism (HP:0010916)	2.20315467
47	Hyperalaninemia (HP:0003348)	2.20315467
48	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.20315467
49	Abnormality of the preputium (HP:0100587)	2.20113154
50	Genital tract atresia (HP:0001827)	2.19931447
51	Absent thumb (HP:0009777)	2.17209988
52	Abnormality of the anterior horn cell (HP:0006802)	2.16424236
53	Degeneration of anterior horn cells (HP:0002398)	2.16424236
54	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.13515748
55	Vaginal atresia (HP:0000148)	2.12678247
56	Abnormality of the duodenum (HP:0002246)	2.09696146
57	Choroideremia (HP:0001139)	2.09296915
58	Hypomagnesemia (HP:0002917)	2.09193257
59	Lactic acidosis (HP:0003128)	2.07982076
60	Neoplasm of the adrenal gland (HP:0100631)	2.05116273
61	Triphalangeal thumb (HP:0001199)	2.05059015
62	Hypoplastic pelvis (HP:0008839)	2.03842290
63	Congenital stationary night blindness (HP:0007642)	2.03317627
64	Congenital primary aphakia (HP:0007707)	2.02557607
65	Optic nerve hypoplasia (HP:0000609)	2.01537526
66	Gait imbalance (HP:0002141)	1.98870662
67	Lethargy (HP:0001254)	1.98479264
68	Abnormal rod and cone electroretinograms (HP:0008323)	1.96300718
69	Abnormality of the renal medulla (HP:0100957)	1.95735451
70	Anophthalmia (HP:0000528)	1.95650153
71	Increased hepatocellular lipid droplets (HP:0006565)	1.94487577
72	Decreased subcutaneous fat (HP:0001002)	1.94142809
73	Abnormal hair whorl (HP:0010721)	1.91314735
74	Aqueductal stenosis (HP:0002410)	1.91158314
75	Optic disc pallor (HP:0000543)	1.91117751
76	Decreased muscle mass (HP:0003199)	1.87776917
77	Respiratory failure (HP:0002878)	1.86525523
78	Abnormal lung lobation (HP:0002101)	1.86410737
79	Aplastic anemia (HP:0001915)	1.86072735
80	Abnormality of the labia minora (HP:0012880)	1.84203127
81	Pheochromocytoma (HP:0002666)	1.83938336
82	Renal Fanconi syndrome (HP:0001994)	1.81464034
83	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.81033775
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.80113757
85	Thyroiditis (HP:0100646)	1.80059155
86	Male pseudohermaphroditism (HP:0000037)	1.79253584
87	Lipid accumulation in hepatocytes (HP:0006561)	1.78996805
88	Oligodactyly (HP:0012165)	1.78373980
89	Chronic bronchitis (HP:0004469)	1.78100481
90	Abnormality of serum amino acid levels (HP:0003112)	1.77670197
91	Neoplasm of the peripheral nervous system (HP:0100007)	1.76809050
92	Cerebral hypomyelination (HP:0006808)	1.76337754
93	Short chin (HP:0000331)	1.76187362
94	Attenuation of retinal blood vessels (HP:0007843)	1.75255755
95	Constricted visual fields (HP:0001133)	1.74909781
96	Abnormality of the renal cortex (HP:0011035)	1.74740465
97	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.74626132
98	Retinal dysplasia (HP:0007973)	1.74168540
99	Hypothermia (HP:0002045)	1.73219506
100	Chromsome breakage (HP:0040012)	1.72927457

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	4.22004985
2	FRK	3.02389675
3	PINK1	2.94783719
4	BCKDK	2.42911652
5	BCR	2.38943294
6	EIF2AK3	2.35908167
7	NEK1	2.32545671
8	VRK2	2.32405083
9	BMPR1B	2.27280732
10	MKNK2	2.22407306
11	MAP3K12	2.17402385
12	SRPK1	2.09325907
13	MST4	1.82823078
14	TXK	1.80954606
15	MKNK1	1.74430154
16	ZAK	1.68449073
17	BUB1	1.66497503
18	TLK1	1.65708480
19	ADRBK2	1.64427597
20	EIF2AK1	1.62941201
21	CSNK1G3	1.62240426
22	TRIM28	1.61472561
23	TSSK6	1.61337063
24	TESK2	1.58552650
25	CSNK1A1L	1.52746803
26	ACVR1B	1.51527171
27	TNIK	1.50574068
28	WNK3	1.44804094
29	VRK1	1.39527864
30	MAPK13	1.39357178
31	PLK3	1.39321693
32	CSNK1G1	1.35361458
33	CDC7	1.35157453
34	CAMKK2	1.31172083
35	NUAK1	1.28659033
36	CSNK1G2	1.27182405
37	BRSK2	1.23332443
38	GRK1	1.22756341
39	MAP4K2	1.21677824
40	TAOK3	1.16638262
41	OXSR1	1.14790629
42	PLK2	1.12756563
43	STK39	1.08354544
44	DYRK2	1.01313415
45	WNK4	1.00144964
46	PASK	0.95787324
47	PLK4	0.94336956
48	ERBB3	0.91710864
49	PHKG1	0.90064166
50	PHKG2	0.90064166
51	TAF1	0.89069278
52	NEK2	0.86137485
53	PDK2	0.82612656
54	INSRR	0.78408442
55	PLK1	0.76830677
56	MARK1	0.72784629
57	FGFR2	0.70528747
58	PIK3CG	0.70107132
59	CCNB1	0.65385021
60	PRKCE	0.63735277
61	FES	0.62773072
62	LIMK1	0.59619919
63	OBSCN	0.58722536
64	AKT3	0.56402487
65	DAPK1	0.54835761
66	MINK1	0.54484693
67	CAMK1D	0.54277593
68	NLK	0.53124414
69	AURKB	0.52548956
70	CHEK2	0.51936368
71	CAMK1G	0.50932793
72	TEC	0.49895800
73	STK38L	0.49241217
74	DAPK2	0.49011335
75	RPS6KA4	0.48539991
76	TGFBR1	0.48500641
77	NME1	0.47901282
78	CSNK2A1	0.47778565
79	CSF1R	0.47725930
80	PRKCG	0.44595931
81	ATR	0.44306686
82	KDR	0.43899785
83	STK16	0.43876697
84	CSNK1A1	0.42886697
85	ADRBK1	0.42792078
86	TTK	0.41873553
87	CDK19	0.41775717
88	CDK7	0.41296584
89	TIE1	0.40978893
90	AURKA	0.40572638
91	CSNK2A2	0.39953035
92	ITK	0.39537579
93	RPS6KA5	0.39249611
94	CSNK1D	0.36518150
95	PIK3CA	0.35339490
96	CAMK2A	0.35255499
97	DYRK3	0.34934882
98	FLT3	0.33929018
99	PRKACA	0.33101815
100	STK11	0.31234145

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.97885125
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.39281421
3	RNA polymerase_Homo sapiens_hsa03020	3.09688047
4	Parkinsons disease_Homo sapiens_hsa05012	2.89933300
5	Protein export_Homo sapiens_hsa03060	2.70344256
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.44869959
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.36302095
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.19806175
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.18562459
10	Ribosome_Homo sapiens_hsa03010	2.11676170
11	Homologous recombination_Homo sapiens_hsa03440	2.09956137
12	Alzheimers disease_Homo sapiens_hsa05010	1.88221649
13	Asthma_Homo sapiens_hsa05310	1.87929169
14	Spliceosome_Homo sapiens_hsa03040	1.82265511
15	RNA transport_Homo sapiens_hsa03013	1.75968436
16	Huntingtons disease_Homo sapiens_hsa05016	1.72398886
17	Phototransduction_Homo sapiens_hsa04744	1.72092534
18	RNA degradation_Homo sapiens_hsa03018	1.69075308
19	Mismatch repair_Homo sapiens_hsa03430	1.61980242
20	Steroid biosynthesis_Homo sapiens_hsa00100	1.59916134
21	Fatty acid elongation_Homo sapiens_hsa00062	1.54319219
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.51377432
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.49496397
24	One carbon pool by folate_Homo sapiens_hsa00670	1.49463429
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.47240274
26	DNA replication_Homo sapiens_hsa03030	1.47010016
27	Butanoate metabolism_Homo sapiens_hsa00650	1.44295112
28	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.43751323
29	Nicotine addiction_Homo sapiens_hsa05033	1.39656677
30	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.38626015
31	Allograft rejection_Homo sapiens_hsa05330	1.38021960
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.37308423
33	Basal transcription factors_Homo sapiens_hsa03022	1.36186196
34	Olfactory transduction_Homo sapiens_hsa04740	1.31727428
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.30448269
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.27481981
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.25037655
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24404644
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24182827
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.21858633
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.18963407
42	Non-homologous end-joining_Homo sapiens_hsa03450	1.15944702
43	Linoleic acid metabolism_Homo sapiens_hsa00591	1.13836401
44	Base excision repair_Homo sapiens_hsa03410	1.13748319
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12011696
46	Propanoate metabolism_Homo sapiens_hsa00640	1.08543471
47	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.03801182
48	Tryptophan metabolism_Homo sapiens_hsa00380	1.01151002
49	Peroxisome_Homo sapiens_hsa04146	0.99589671
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.99300675
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.97492628
52	Purine metabolism_Homo sapiens_hsa00230	0.95909583
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.95330889
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.91533353
55	Pyruvate metabolism_Homo sapiens_hsa00620	0.89173323
56	Morphine addiction_Homo sapiens_hsa05032	0.84427965
57	Primary immunodeficiency_Homo sapiens_hsa05340	0.84214750
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.82136242
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.80524813
60	GABAergic synapse_Homo sapiens_hsa04727	0.79550035
61	Taste transduction_Homo sapiens_hsa04742	0.76175200
62	Metabolic pathways_Homo sapiens_hsa01100	0.73002199
63	Selenocompound metabolism_Homo sapiens_hsa00450	0.71665589
64	Nitrogen metabolism_Homo sapiens_hsa00910	0.71029900
65	Caffeine metabolism_Homo sapiens_hsa00232	0.65622806
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.62492771
67	Cell cycle_Homo sapiens_hsa04110	0.58275401
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57553305
69	Regulation of autophagy_Homo sapiens_hsa04140	0.57026905
70	Glutathione metabolism_Homo sapiens_hsa00480	0.56787792
71	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.54537202
72	Serotonergic synapse_Homo sapiens_hsa04726	0.54015030
73	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.53273366
74	Fatty acid metabolism_Homo sapiens_hsa01212	0.51410387
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50169043
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48359180
77	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47113077
78	mRNA surveillance pathway_Homo sapiens_hsa03015	0.46851500
79	Oocyte meiosis_Homo sapiens_hsa04114	0.46466520
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44765693
81	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.43234538
82	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42725607
83	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.41240322
84	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.40180173
85	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.39188106
86	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.38645231
87	Alcoholism_Homo sapiens_hsa05034	0.38263770
88	Fatty acid degradation_Homo sapiens_hsa00071	0.38178783
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.37306070
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.36439277
91	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.35931041
92	Circadian entrainment_Homo sapiens_hsa04713	0.33859544
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32080982
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.31478097
95	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30235522
96	Arginine and proline metabolism_Homo sapiens_hsa00330	0.29824783
97	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.26955026
98	Type I diabetes mellitus_Homo sapiens_hsa04940	0.24972204
99	Long-term depression_Homo sapiens_hsa04730	0.24192583
100	Renin-angiotensin system_Homo sapiens_hsa04614	0.23436251

OLA1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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