ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.08195442
2	tryptophan catabolic process (GO:0006569)	4.88831930
3	indole-containing compound catabolic process (GO:0042436)	4.88831930
4	indolalkylamine catabolic process (GO:0046218)	4.88831930
5	indolalkylamine metabolic process (GO:0006586)	4.61591540
6	kynurenine metabolic process (GO:0070189)	4.57796210
7	L-fucose catabolic process (GO:0042355)	4.41375726
8	fucose catabolic process (GO:0019317)	4.41375726
9	L-fucose metabolic process (GO:0042354)	4.41375726
10	tryptophan metabolic process (GO:0006568)	4.22085001
11	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.18812688
12	response to pheromone (GO:0019236)	4.09328104
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.70164060
14	detection of light stimulus involved in sensory perception (GO:0050962)	3.66964334
15	detection of light stimulus involved in visual perception (GO:0050908)	3.66964334
16	cellular ketone body metabolic process (GO:0046950)	3.65585984
17	photoreceptor cell maintenance (GO:0045494)	3.64338760
18	neural tube formation (GO:0001841)	3.47901252
19	DNA deamination (GO:0045006)	3.42671820
20	indole-containing compound metabolic process (GO:0042430)	3.42465669
21	regulation of hippo signaling (GO:0035330)	3.40519798
22	auditory receptor cell stereocilium organization (GO:0060088)	3.38649136
23	protein K11-linked deubiquitination (GO:0035871)	3.37933291
24	cilium or flagellum-dependent cell motility (GO:0001539)	3.36317344
25	gamma-aminobutyric acid transport (GO:0015812)	3.32854960
26	ketone body metabolic process (GO:1902224)	3.29272086
27	piRNA metabolic process (GO:0034587)	3.25794370
28	axoneme assembly (GO:0035082)	3.21242169
29	reflex (GO:0060004)	3.16200595
30	retinal cone cell development (GO:0046549)	3.15944629
31	amine catabolic process (GO:0009310)	3.15669844
32	cellular biogenic amine catabolic process (GO:0042402)	3.15669844
33	behavioral response to ethanol (GO:0048149)	3.13960504
34	inner ear receptor stereocilium organization (GO:0060122)	3.04251576
35	sulfation (GO:0051923)	3.00482118
36	signal peptide processing (GO:0006465)	2.98297982
37	epithelial cilium movement (GO:0003351)	2.95446970
38	tachykinin receptor signaling pathway (GO:0007217)	2.92593729
39	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.91682230
40	benzene-containing compound metabolic process (GO:0042537)	2.91642532
41	reciprocal meiotic recombination (GO:0007131)	2.89225761
42	reciprocal DNA recombination (GO:0035825)	2.89225761
43	DNA double-strand break processing (GO:0000729)	2.89025632
44	negative regulation of mast cell activation (GO:0033004)	2.88494655
45	adaptation of signaling pathway (GO:0023058)	2.87319436
46	protein polyglutamylation (GO:0018095)	2.85758422
47	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.80200649
48	neuronal action potential (GO:0019228)	2.80187568
49	kidney morphogenesis (GO:0060993)	2.78380034
50	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.78261215
51	DNA methylation involved in gamete generation (GO:0043046)	2.77943427
52	thyroid hormone metabolic process (GO:0042403)	2.75296553
53	nonmotile primary cilium assembly (GO:0035058)	2.74968202
54	double-strand break repair via homologous recombination (GO:0000724)	2.74627491
55	recombinational repair (GO:0000725)	2.73872527
56	centriole replication (GO:0007099)	2.72160055
57	aromatic amino acid family catabolic process (GO:0009074)	2.71644214
58	primary amino compound metabolic process (GO:1901160)	2.70685251
59	cilium morphogenesis (GO:0060271)	2.70309527
60	oxidative demethylation (GO:0070989)	2.68720159
61	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.68557111
62	multicellular organism reproduction (GO:0032504)	2.68310848
63	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.67718176
64	serotonin metabolic process (GO:0042428)	2.67093744
65	regulation of cilium movement (GO:0003352)	2.66733545
66	rhodopsin mediated signaling pathway (GO:0016056)	2.65814805
67	replication fork processing (GO:0031297)	2.65137572
68	water-soluble vitamin biosynthetic process (GO:0042364)	2.63632913
69	cilium movement (GO:0003341)	2.63210561
70	establishment of protein localization to Golgi (GO:0072600)	2.61842400
71	platelet dense granule organization (GO:0060155)	2.61499864
72	cilium organization (GO:0044782)	2.60627805
73	photoreceptor cell development (GO:0042461)	2.58680697
74	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.57889031
75	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.57546795
76	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.57546795
77	regulation of translation, ncRNA-mediated (GO:0045974)	2.57546795
78	NAD biosynthetic process (GO:0009435)	2.56975651
79	regulation of meiosis I (GO:0060631)	2.54244572
80	drug catabolic process (GO:0042737)	2.51229702
81	dopamine transport (GO:0015872)	2.51035712
82	cilium assembly (GO:0042384)	2.50960457
83	rRNA catabolic process (GO:0016075)	2.48800762
84	regulation of action potential (GO:0098900)	2.48160323
85	synapsis (GO:0007129)	2.46171980
86	neuronal action potential propagation (GO:0019227)	2.46164964
87	respiratory chain complex IV assembly (GO:0008535)	2.46110859
88	negative regulation of systemic arterial blood pressure (GO:0003085)	2.44086720
89	startle response (GO:0001964)	2.43666857
90	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.43526958
91	cornea development in camera-type eye (GO:0061303)	2.43310615
92	protein prenylation (GO:0018342)	2.42450679
93	prenylation (GO:0097354)	2.42450679
94	protein localization to cilium (GO:0061512)	2.42101935
95	negative regulation of telomere maintenance (GO:0032205)	2.40967662
96	protein K63-linked deubiquitination (GO:0070536)	2.40936839
97	male meiosis (GO:0007140)	2.40239169
98	transmission of nerve impulse (GO:0019226)	2.39869701
99	aromatic amino acid family metabolic process (GO:0009072)	2.38771124
100	positive regulation of developmental pigmentation (GO:0048087)	2.36436432

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.73539595
2	VDR_22108803_ChIP-Seq_LS180_Human	3.43293082
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.36930882
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.78039781
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.72507911
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69456139
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.68396289
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.62079362
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.52920235
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35395448
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.31065818
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.19332586
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.15126637
14	P300_19829295_ChIP-Seq_ESCs_Human	2.13178667
15	EWS_26573619_Chip-Seq_HEK293_Human	2.12180568
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06717347
17	FUS_26573619_Chip-Seq_HEK293_Human	2.06154733
18	ER_23166858_ChIP-Seq_MCF-7_Human	2.01386566
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.99598499
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.96014981
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.85036237
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82874571
23	STAT3_23295773_ChIP-Seq_U87_Human	1.79090885
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71877636
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.70008623
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.69409940
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.68316986
28	TCF4_23295773_ChIP-Seq_U87_Human	1.65983721
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.65512393
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63419473
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.60808186
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.60808186
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.56310538
34	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.55247763
35	AR_25329375_ChIP-Seq_VCAP_Human	1.52596843
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50751485
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.50751485
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50480277
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.47836333
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.43976107
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.42632122
42	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41419015
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40949914
44	TCF4_22108803_ChIP-Seq_LS180_Human	1.40066624
45	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.40028422
46	AR_21572438_ChIP-Seq_LNCaP_Human	1.39479549
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37921354
48	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.36610668
49	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.36419755
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.35948842
51	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.34621538
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34409250
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34409250
54	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31796781
55	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.31361627
56	RUNX2_22187159_ChIP-Seq_PCA_Human	1.31032090
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30870579
58	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28320282
59	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.28122370
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27681742
61	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.26763325
62	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.26351758
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.25576680
64	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24152924
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.21714846
66	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21223113
67	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21055086
68	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.20913322
69	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20804264
70	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20779551
71	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20779551
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20685043
73	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.20139685
74	IRF1_19129219_ChIP-ChIP_H3396_Human	1.19823117
75	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.15829012
76	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15535759
77	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.15177854
78	CDX2_22108803_ChIP-Seq_LS180_Human	1.12307468
79	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.12185418
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.12092924
81	TP53_16413492_ChIP-PET_HCT116_Human	1.11333558
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10300652
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09935261
84	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09236633
85	NCOR_22424771_ChIP-Seq_293T_Human	1.08021147
86	AR_20517297_ChIP-Seq_VCAP_Human	1.06090594
87	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05674908
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04938815
89	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04762194
90	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.04546680
91	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.03094868
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03042774
93	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02258495
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02245534
95	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.00662260
96	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.00485706
97	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99376665
98	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98640965
99	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97050529
100	MYC_18940864_ChIP-ChIP_HL60_Human	0.96682421

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.56279349
2	MP0000569_abnormal_digit_pigmentation	3.27003166
3	MP0008877_abnormal_DNA_methylation	2.78621257
4	MP0005551_abnormal_eye_electrophysiolog	2.66041384
5	MP0001968_abnormal_touch/_nociception	2.49257300
6	MP0002102_abnormal_ear_morphology	2.32474498
7	MP0004043_abnormal_pH_regulation	2.19771400
8	MP0009046_muscle_twitch	2.17375486
9	MP0001501_abnormal_sleep_pattern	2.14522984
10	MP0002736_abnormal_nociception_after	2.12152850
11	MP0008872_abnormal_physiological_respon	2.11525130
12	MP0003646_muscle_fatigue	2.11364178
13	MP0005646_abnormal_pituitary_gland	2.01013185
14	MP0000427_abnormal_hair_cycle	1.94905524
15	MP0009745_abnormal_behavioral_response	1.94103142
16	MP0005253_abnormal_eye_physiology	1.88844287
17	MP0008875_abnormal_xenobiotic_pharmacok	1.84944740
18	MP0002837_dystrophic_cardiac_calcinosis	1.82009292
19	MP0002876_abnormal_thyroid_physiology	1.79579355
20	MP0003136_yellow_coat_color	1.78903093
21	MP0001485_abnormal_pinna_reflex	1.73387988
22	MP0004147_increased_porphyrin_level	1.69913780
23	MP0001986_abnormal_taste_sensitivity	1.68982646
24	MP0002735_abnormal_chemical_nociception	1.67302947
25	MP0005645_abnormal_hypothalamus_physiol	1.66092822
26	MP0006276_abnormal_autonomic_nervous	1.63726400
27	MP0006072_abnormal_retinal_apoptosis	1.62773417
28	MP0001486_abnormal_startle_reflex	1.62753804
29	MP0004142_abnormal_muscle_tone	1.61111591
30	MP0000372_irregular_coat_pigmentation	1.60604081
31	MP0002272_abnormal_nervous_system	1.59246042
32	MP0002138_abnormal_hepatobiliary_system	1.58631023
33	MP0003787_abnormal_imprinting	1.57690074
34	MP0000383_abnormal_hair_follicle	1.54870742
35	MP0001984_abnormal_olfaction	1.53168236
36	MP0004885_abnormal_endolymph	1.51614955
37	MP0002638_abnormal_pupillary_reflex	1.49809415
38	MP0010386_abnormal_urinary_bladder	1.47977469
39	MP0008057_abnormal_DNA_replication	1.47581075
40	MP0002938_white_spotting	1.39520013
41	MP0004742_abnormal_vestibular_system	1.37821040
42	MP0004145_abnormal_muscle_electrophysio	1.35057439
43	MP0000631_abnormal_neuroendocrine_gland	1.34183029
44	MP0003252_abnormal_bile_duct	1.32509512
45	MP0002572_abnormal_emotion/affect_behav	1.32320129
46	MP0004924_abnormal_behavior	1.29145459
47	MP0005386_behavior/neurological_phenoty	1.29145459
48	MP0005085_abnormal_gallbladder_physiolo	1.28807262
49	MP0006292_abnormal_olfactory_placode	1.27409702
50	MP0001970_abnormal_pain_threshold	1.25648125
51	MP0005174_abnormal_tail_pigmentation	1.24343595
52	MP0002733_abnormal_thermal_nociception	1.23034129
53	MP0002064_seizures	1.22485172
54	MP0003880_abnormal_central_pattern	1.21593499
55	MP0005167_abnormal_blood-brain_barrier	1.21273996
56	MP0002557_abnormal_social/conspecific_i	1.19354564
57	MP0002067_abnormal_sensory_capabilities	1.17474799
58	MP0003718_maternal_effect	1.15017599
59	MP0005410_abnormal_fertilization	1.14050958
60	MP0005377_hearing/vestibular/ear_phenot	1.12961044
61	MP0003878_abnormal_ear_physiology	1.12961044
62	MP0002928_abnormal_bile_duct	1.12713401
63	MP0001529_abnormal_vocalization	1.11947974
64	MP0005389_reproductive_system_phenotype	1.06266290
65	MP0004215_abnormal_myocardial_fiber	1.05482556
66	MP0003635_abnormal_synaptic_transmissio	1.05331387
67	MP0000230_abnormal_systemic_arterial	1.02919502
68	MP0004133_heterotaxia	1.02340693
69	MP0005084_abnormal_gallbladder_morpholo	1.02066371
70	MP0008058_abnormal_DNA_repair	1.00042990
71	MP0002653_abnormal_ependyma_morphology	0.99970695
72	MP0002234_abnormal_pharynx_morphology	0.99575609
73	MP0000538_abnormal_urinary_bladder	0.99556083
74	MP0003011_delayed_dark_adaptation	0.98667511
75	MP0002160_abnormal_reproductive_system	0.96596471
76	MP0003698_abnormal_male_reproductive	0.96289916
77	MP0002063_abnormal_learning/memory/cond	0.92719839
78	MP0005195_abnormal_posterior_eye	0.92442284
79	MP0002751_abnormal_autonomic_nervous	0.91248840
80	MP0008995_early_reproductive_senescence	0.90785002
81	MP0002229_neurodegeneration	0.90492219
82	MP0003045_fibrosis	0.89201500
83	MP0008961_abnormal_basal_metabolism	0.89137076
84	MP0002095_abnormal_skin_pigmentation	0.88536149
85	MP0001929_abnormal_gametogenesis	0.87698336
86	MP0005171_absent_coat_pigmentation	0.84685614
87	MP0001764_abnormal_homeostasis	0.84575793
88	MP0003950_abnormal_plasma_membrane	0.84361412
89	MP0003137_abnormal_impulse_conducting	0.83646291
90	MP0008775_abnormal_heart_ventricle	0.82921357
91	MP0001919_abnormal_reproductive_system	0.82278736
92	MP0002734_abnormal_mechanical_nocicepti	0.81471534
93	MP0002752_abnormal_somatic_nervous	0.80603598
94	MP0002168_other_aberrant_phenotype	0.78506075
95	MP0001963_abnormal_hearing_physiology	0.78250083
96	MP0003119_abnormal_digestive_system	0.77224601
97	MP0005395_other_phenotype	0.76410489
98	MP0003890_abnormal_embryonic-extraembry	0.75521551
99	MP0001905_abnormal_dopamine_level	0.75017274
100	MP0000647_abnormal_sebaceous_gland	0.74850119

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.75022298
2	Pancreatic fibrosis (HP:0100732)	4.16984339
3	True hermaphroditism (HP:0010459)	4.01111912
4	Hyperventilation (HP:0002883)	4.00058325
5	Molar tooth sign on MRI (HP:0002419)	3.75732986
6	Abnormality of midbrain morphology (HP:0002418)	3.75732986
7	Congenital stationary night blindness (HP:0007642)	3.74206896
8	Abnormality of the renal cortex (HP:0011035)	3.64393585
9	Attenuation of retinal blood vessels (HP:0007843)	3.57772545
10	Nephronophthisis (HP:0000090)	3.43393763
11	Gaze-evoked nystagmus (HP:0000640)	3.26128281
12	Abnormality of the renal medulla (HP:0100957)	3.23175496
13	Type II lissencephaly (HP:0007260)	3.08253930
14	Genetic anticipation (HP:0003743)	3.06659619
15	Chronic hepatic failure (HP:0100626)	3.06099634
16	Medial flaring of the eyebrow (HP:0010747)	3.01961520
17	Abolished electroretinogram (ERG) (HP:0000550)	2.99688546
18	Cystic liver disease (HP:0006706)	2.93935195
19	Progressive cerebellar ataxia (HP:0002073)	2.77615873
20	Protruding tongue (HP:0010808)	2.65811457
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.65555342
22	Tubular atrophy (HP:0000092)	2.65291132
23	Renal cortical cysts (HP:0000803)	2.58530025
24	Decreased circulating renin level (HP:0003351)	2.57647620
25	Febrile seizures (HP:0002373)	2.57546085
26	Cerebellar dysplasia (HP:0007033)	2.54664801
27	Abnormal drinking behavior (HP:0030082)	2.53034051
28	Polydipsia (HP:0001959)	2.53034051
29	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.51181351
30	Pendular nystagmus (HP:0012043)	2.50814459
31	Inability to walk (HP:0002540)	2.49779257
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.49276678
33	Decreased central vision (HP:0007663)	2.48986525
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.48098201
35	Abnormality of alanine metabolism (HP:0010916)	2.48098201
36	Hyperalaninemia (HP:0003348)	2.48098201
37	Absent/shortened dynein arms (HP:0200106)	2.47656047
38	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.47656047
39	Keratoconus (HP:0000563)	2.47629687
40	Increased corneal curvature (HP:0100692)	2.47629687
41	Bony spicule pigmentary retinopathy (HP:0007737)	2.45589899
42	Progressive inability to walk (HP:0002505)	2.40921294
43	Clumsiness (HP:0002312)	2.38171084
44	Stomach cancer (HP:0012126)	2.36342513
45	Large for gestational age (HP:0001520)	2.36119500
46	Gait imbalance (HP:0002141)	2.31747489
47	Congenital hepatic fibrosis (HP:0002612)	2.30396559
48	Fair hair (HP:0002286)	2.30140640
49	Sclerocornea (HP:0000647)	2.30013179
50	Congenital sensorineural hearing impairment (HP:0008527)	2.29951256
51	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.26881379
52	Congenital primary aphakia (HP:0007707)	2.25994181
53	Absent speech (HP:0001344)	2.18608460
54	Furrowed tongue (HP:0000221)	2.14944594
55	Lissencephaly (HP:0001339)	2.14148909
56	Broad-based gait (HP:0002136)	2.13974168
57	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.12472522
58	Abnormality of macular pigmentation (HP:0008002)	2.11350240
59	Genital tract atresia (HP:0001827)	2.11315735
60	Hypothermia (HP:0002045)	2.07052061
61	Anencephaly (HP:0002323)	2.06486591
62	Nephrogenic diabetes insipidus (HP:0009806)	2.06397599
63	Polyuria (HP:0000103)	2.05676572
64	Intestinal atresia (HP:0011100)	2.01295520
65	Vaginal atresia (HP:0000148)	2.00114850
66	Patellar aplasia (HP:0006443)	1.96312368
67	Focal seizures (HP:0007359)	1.95308546
68	Postaxial foot polydactyly (HP:0001830)	1.94926746
69	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.94792977
70	Chorioretinal atrophy (HP:0000533)	1.93328003
71	Widely spaced teeth (HP:0000687)	1.92387650
72	Abnormal biliary tract physiology (HP:0012439)	1.91437203
73	Bile duct proliferation (HP:0001408)	1.91437203
74	Constricted visual fields (HP:0001133)	1.90685305
75	Male pseudohermaphroditism (HP:0000037)	1.89956599
76	Congenital, generalized hypertrichosis (HP:0004540)	1.89811645
77	Focal motor seizures (HP:0011153)	1.89756998
78	Birth length less than 3rd percentile (HP:0003561)	1.85884613
79	Aplasia/Hypoplasia of the patella (HP:0006498)	1.85506721
80	Dialeptic seizures (HP:0011146)	1.84915802
81	Generalized hypopigmentation of hair (HP:0011358)	1.83551014
82	Small hand (HP:0200055)	1.82114910
83	Ketoacidosis (HP:0001993)	1.81633489
84	Abnormal respiratory epithelium morphology (HP:0012253)	1.79949205
85	Abnormal respiratory motile cilium morphology (HP:0005938)	1.79949205
86	Pachygyria (HP:0001302)	1.79005787
87	Retinitis pigmentosa (HP:0000510)	1.79001582
88	Abnormal ciliary motility (HP:0012262)	1.78457817
89	Optic nerve hypoplasia (HP:0000609)	1.77476573
90	Tubulointerstitial abnormality (HP:0001969)	1.76906809
91	Colon cancer (HP:0003003)	1.75768295
92	Astigmatism (HP:0000483)	1.75091361
93	Abnormality of the ileum (HP:0001549)	1.74996069
94	Poor coordination (HP:0002370)	1.74542121
95	Abnormality of the pons (HP:0007361)	1.74443258
96	Hemiparesis (HP:0001269)	1.73224901
97	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.72975128
98	Ketosis (HP:0001946)	1.72313468
99	Abnormality of the labia minora (HP:0012880)	1.71753260
100	Clubbing of toes (HP:0100760)	1.70610354

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.52883298
2	BMPR1B	3.57645061
3	ADRBK2	2.88212897
4	ACVR1B	2.83413185
5	WNK3	2.56003509
6	NUAK1	2.38807084
7	ZAK	2.31076910
8	INSRR	2.29020437
9	MAP4K2	2.28769882
10	GRK1	1.99118669
11	CASK	1.97806874
12	TAOK3	1.93339279
13	PINK1	1.79064788
14	MAPK13	1.77907646
15	WNK4	1.73783215
16	OXSR1	1.61931494
17	TXK	1.60889389
18	MAP3K4	1.58746091
19	TLK1	1.53998241
20	MKNK2	1.53709358
21	STK39	1.47829712
22	STK38L	1.35747195
23	DAPK2	1.34232237
24	TNIK	1.31936905
25	TGFBR1	1.31552151
26	TRIM28	1.24638540
27	ADRBK1	1.22939400
28	NTRK3	1.16786643
29	PRKCE	0.97764561
30	PAK3	0.95165404
31	MARK1	0.95136415
32	PNCK	0.91991127
33	CAMKK2	0.91563733
34	BRSK2	0.86984993
35	TEC	0.85362278
36	PRKCG	0.83846651
37	VRK1	0.81515420
38	PIK3CA	0.80739529
39	PLK2	0.79261339
40	PTK2B	0.79123265
41	PIK3CG	0.78670854
42	BCKDK	0.77929606
43	NEK2	0.76599931
44	MAP2K7	0.75947652
45	MKNK1	0.75361369
46	EIF2AK3	0.70323845
47	FGFR2	0.69269948
48	CSNK1G2	0.69035324
49	AKT3	0.67821076
50	CSNK1G1	0.67214938
51	CSNK1A1L	0.66632521
52	STK3	0.66595322
53	EPHA4	0.65636683
54	DYRK2	0.63082052
55	PKN1	0.62905060
56	BCR	0.62867007
57	PLK4	0.60439922
58	LATS1	0.59151893
59	CSNK1G3	0.58340218
60	IRAK1	0.57985273
61	FER	0.57584868
62	ERBB3	0.56532971
63	TIE1	0.56321280
64	TNK2	0.56263702
65	MAPKAPK5	0.56158706
66	ITK	0.53997098
67	MAPKAPK3	0.50958725
68	CAMK2A	0.50927517
69	TAF1	0.50221160
70	MUSK	0.49759508
71	PRKCQ	0.49539402
72	PHKG1	0.48840990
73	PHKG2	0.48840990
74	NLK	0.48338650
75	WEE1	0.47681240
76	FLT3	0.47250954
77	GRK7	0.46867201
78	OBSCN	0.46507178
79	CAMK1	0.45532266
80	NTRK2	0.45271735
81	IKBKB	0.45044311
82	KIT	0.44772351
83	SIK2	0.44707144
84	CAMK1D	0.44143885
85	CHUK	0.44059887
86	PRKAA2	0.43729086
87	CAMK1G	0.43715666
88	NME1	0.43697305
89	SGK2	0.43023619
90	PLK3	0.42923138
91	MAP2K6	0.42159956
92	GRK5	0.41588633
93	STK11	0.39602591
94	RPS6KA5	0.39262224
95	MAPK15	0.39098574
96	MST4	0.39074407
97	CCNB1	0.38301911
98	CSNK1D	0.37722786
99	PRKACA	0.36885512
100	EPHA3	0.35952945

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.92162210
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.84143198
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.81386465
4	Butanoate metabolism_Homo sapiens_hsa00650	2.53434606
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.47401007
6	Nicotine addiction_Homo sapiens_hsa05033	2.37124268
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.28651195
8	Tryptophan metabolism_Homo sapiens_hsa00380	2.24493411
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.22520788
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.15217277
11	Caffeine metabolism_Homo sapiens_hsa00232	2.14177592
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.13433284
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.11885338
14	Ether lipid metabolism_Homo sapiens_hsa00565	1.94036913
15	Homologous recombination_Homo sapiens_hsa03440	1.86120283
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.83485358
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.83279134
18	ABC transporters_Homo sapiens_hsa02010	1.76120268
19	Taste transduction_Homo sapiens_hsa04742	1.71853466
20	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.70664300
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.70501380
22	Propanoate metabolism_Homo sapiens_hsa00640	1.65759579
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59523447
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.57334918
25	Morphine addiction_Homo sapiens_hsa05032	1.52377000
26	Basal transcription factors_Homo sapiens_hsa03022	1.50921259
27	Olfactory transduction_Homo sapiens_hsa04740	1.44225338
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.43369013
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.39905183
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.36572406
31	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.33317611
32	Chemical carcinogenesis_Homo sapiens_hsa05204	1.31131831
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.30591560
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.24560259
35	Serotonergic synapse_Homo sapiens_hsa04726	1.22455478
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.21893720
37	Retinol metabolism_Homo sapiens_hsa00830	1.21693901
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.19899104
39	Circadian entrainment_Homo sapiens_hsa04713	1.17327932
40	GABAergic synapse_Homo sapiens_hsa04727	1.14859155
41	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.13295099
42	Glutamatergic synapse_Homo sapiens_hsa04724	1.12196610
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.11658473
44	RNA polymerase_Homo sapiens_hsa03020	1.11513279
45	Peroxisome_Homo sapiens_hsa04146	1.08786321
46	One carbon pool by folate_Homo sapiens_hsa00670	1.03421897
47	Glycerolipid metabolism_Homo sapiens_hsa00561	0.97989929
48	Regulation of autophagy_Homo sapiens_hsa04140	0.96403511
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95884892
50	Histidine metabolism_Homo sapiens_hsa00340	0.95030754
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.94493269
52	Insulin secretion_Homo sapiens_hsa04911	0.93506072
53	Salivary secretion_Homo sapiens_hsa04970	0.93068552
54	Calcium signaling pathway_Homo sapiens_hsa04020	0.91723947
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.86615270
56	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.85089681
57	Oxidative phosphorylation_Homo sapiens_hsa00190	0.84076300
58	RNA degradation_Homo sapiens_hsa03018	0.83460861
59	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.82955652
60	Protein export_Homo sapiens_hsa03060	0.82072222
61	Asthma_Homo sapiens_hsa05310	0.78466061
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.72078919
63	Non-homologous end-joining_Homo sapiens_hsa03450	0.70509134
64	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66684629
65	Lysine degradation_Homo sapiens_hsa00310	0.62561705
66	Fatty acid degradation_Homo sapiens_hsa00071	0.62177296
67	Long-term depression_Homo sapiens_hsa04730	0.61682977
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.59749330
69	Circadian rhythm_Homo sapiens_hsa04710	0.58269413
70	Dopaminergic synapse_Homo sapiens_hsa04728	0.55331553
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.55190258
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.53773935
73	Purine metabolism_Homo sapiens_hsa00230	0.52986796
74	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.49779351
75	Metabolic pathways_Homo sapiens_hsa01100	0.47904484
76	Cholinergic synapse_Homo sapiens_hsa04725	0.46105322
77	Parkinsons disease_Homo sapiens_hsa05012	0.45887452
78	Primary immunodeficiency_Homo sapiens_hsa05340	0.45127174
79	cAMP signaling pathway_Homo sapiens_hsa04024	0.44244385
80	Renin secretion_Homo sapiens_hsa04924	0.43557110
81	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.43143038
82	Graft-versus-host disease_Homo sapiens_hsa05332	0.41172445
83	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.41164422
84	Sphingolipid metabolism_Homo sapiens_hsa00600	0.40902050
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40842334
86	Huntingtons disease_Homo sapiens_hsa05016	0.40343593
87	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.37460465
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37330353
89	Type I diabetes mellitus_Homo sapiens_hsa04940	0.36575570
90	Collecting duct acid secretion_Homo sapiens_hsa04966	0.35792955
91	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.35484043
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.34957578
93	Mineral absorption_Homo sapiens_hsa04978	0.34542034
94	Gastric acid secretion_Homo sapiens_hsa04971	0.34462045
95	Amphetamine addiction_Homo sapiens_hsa05031	0.33936247
96	Sulfur metabolism_Homo sapiens_hsa00920	0.33294437
97	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.33063082
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.32991101
99	Pancreatic secretion_Homo sapiens_hsa04972	0.32396044
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.31691350

OLA1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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