OLFM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.25014437
2synaptic vesicle maturation (GO:0016188)5.80083331
3locomotory exploration behavior (GO:0035641)5.73086633
4glutamate secretion (GO:0014047)5.69774374
5synaptic vesicle exocytosis (GO:0016079)5.67551967
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.66887636
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.58981650
8vocalization behavior (GO:0071625)5.52464646
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.51308293
10regulation of glutamate receptor signaling pathway (GO:1900449)5.19356992
11protein localization to synapse (GO:0035418)5.16368561
12regulation of synaptic vesicle exocytosis (GO:2000300)5.09070521
13ionotropic glutamate receptor signaling pathway (GO:0035235)5.08333466
14synaptic vesicle docking involved in exocytosis (GO:0016081)5.05729924
15neuronal action potential propagation (GO:0019227)4.87763180
16neuron cell-cell adhesion (GO:0007158)4.85163619
17exploration behavior (GO:0035640)4.73239590
18glutamate receptor signaling pathway (GO:0007215)4.69059975
19regulation of synaptic vesicle transport (GO:1902803)4.61795625
20regulation of neuronal synaptic plasticity (GO:0048168)4.59695581
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.59474630
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.53778060
23synaptic transmission, glutamatergic (GO:0035249)4.39864827
24L-amino acid import (GO:0043092)4.39787372
25neurotransmitter secretion (GO:0007269)4.30800257
26layer formation in cerebral cortex (GO:0021819)4.21156668
27neuronal ion channel clustering (GO:0045161)4.09342131
28neuron-neuron synaptic transmission (GO:0007270)4.08602738
29positive regulation of synapse maturation (GO:0090129)4.06702581
30regulation of excitatory postsynaptic membrane potential (GO:0060079)4.05386646
31neuron recognition (GO:0008038)4.04628471
32dendritic spine morphogenesis (GO:0060997)4.02812825
33neurotransmitter-gated ion channel clustering (GO:0072578)4.00921318
34amino acid import (GO:0043090)3.99443212
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.98934239
36proline transport (GO:0015824)3.97129021
37long-term memory (GO:0007616)3.96996004
38regulation of voltage-gated calcium channel activity (GO:1901385)3.95940865
39cellular potassium ion homeostasis (GO:0030007)3.93060742
40potassium ion homeostasis (GO:0055075)3.91501379
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.90637438
42regulation of synapse structural plasticity (GO:0051823)3.85726044
43regulation of synaptic plasticity (GO:0048167)3.85709937
44regulation of postsynaptic membrane potential (GO:0060078)3.85112985
45regulation of dendritic spine morphogenesis (GO:0061001)3.80942215
46synaptic vesicle endocytosis (GO:0048488)3.79644632
47positive regulation of membrane potential (GO:0045838)3.78432098
48negative regulation of dendrite morphogenesis (GO:0050774)3.76784136
49axonal fasciculation (GO:0007413)3.72453478
50long-term synaptic potentiation (GO:0060291)3.68990125
51gamma-aminobutyric acid transport (GO:0015812)3.58940925
52axon ensheathment in central nervous system (GO:0032291)3.57890400
53central nervous system myelination (GO:0022010)3.57890400
54regulation of neurotransmitter secretion (GO:0046928)3.57333133
55potassium ion import (GO:0010107)3.55301218
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.52804062
57neurotransmitter transport (GO:0006836)3.52687777
58G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.51769830
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.50471215
60regulation of vesicle fusion (GO:0031338)3.49796018
61auditory behavior (GO:0031223)3.46412228
62positive regulation of neurotransmitter secretion (GO:0001956)3.45634129
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45177678
64postsynaptic membrane organization (GO:0001941)3.44611940
65neuromuscular synaptic transmission (GO:0007274)3.41007266
66activation of protein kinase A activity (GO:0034199)3.38377303
67sodium ion export (GO:0071436)3.36572285
68positive regulation of dendritic spine morphogenesis (GO:0061003)3.36458428
69regulation of dendritic spine development (GO:0060998)3.34696927
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.31557092
71presynaptic membrane assembly (GO:0097105)3.30057589
72regulation of ARF protein signal transduction (GO:0032012)3.29514033
73positive regulation of dendritic spine development (GO:0060999)3.28838518
74behavioral defense response (GO:0002209)3.28745195
75behavioral fear response (GO:0001662)3.28745195
76cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28481015
77transmission of nerve impulse (GO:0019226)3.28421693
78dendritic spine organization (GO:0097061)3.27028999
79establishment of synaptic vesicle localization (GO:0097480)3.27024649
80synaptic vesicle transport (GO:0048489)3.27024649
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26966604
82innervation (GO:0060384)3.24787246
83cerebellar Purkinje cell differentiation (GO:0021702)3.24603248
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24045185
85establishment of mitochondrion localization (GO:0051654)3.23062433
86membrane depolarization (GO:0051899)3.22960311
87regulation of neurotransmitter levels (GO:0001505)3.22367013
88fear response (GO:0042596)3.19463298
89neuromuscular process controlling balance (GO:0050885)3.18587492
90regulation of neurotransmitter transport (GO:0051588)3.18487175
91cellular sodium ion homeostasis (GO:0006883)3.17574002
92acidic amino acid transport (GO:0015800)3.17005977
93cell communication by electrical coupling (GO:0010644)3.15166629
94neuromuscular process controlling posture (GO:0050884)3.14030622
95neurotransmitter uptake (GO:0001504)3.13458891
96regulation of synaptic transmission (GO:0050804)3.12555214
97regulation of synapse maturation (GO:0090128)3.11411394
98response to histamine (GO:0034776)3.10132608
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.08771195
100dendrite morphogenesis (GO:0048813)3.08324195
101cerebellar granule cell differentiation (GO:0021707)3.07608146
102positive regulation of neurotransmitter transport (GO:0051590)3.07583555
103learning (GO:0007612)3.07414065
104vesicle docking involved in exocytosis (GO:0006904)3.06433454
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05828419
106neuromuscular process (GO:0050905)3.05433685
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05069566
108presynaptic membrane organization (GO:0097090)3.04672310
109synaptic transmission (GO:0007268)3.03390707
110membrane depolarization during action potential (GO:0086010)3.01319671
111positive regulation of synaptic transmission (GO:0050806)3.00151487
112long term synaptic depression (GO:0060292)2.97022617
113detection of calcium ion (GO:0005513)2.96472380
114vesicle transport along microtubule (GO:0047496)2.95022535
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93922754
116intraspecies interaction between organisms (GO:0051703)2.93711858
117social behavior (GO:0035176)2.93711858
118synapse assembly (GO:0007416)2.89734192
119positive regulation of synaptic transmission, GABAergic (GO:0032230)2.87310641
120membrane hyperpolarization (GO:0060081)2.87055896
121cell migration in hindbrain (GO:0021535)2.87053826
122chemosensory behavior (GO:0007635)2.85399907
123central nervous system projection neuron axonogenesis (GO:0021952)2.83345313

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.58925426
2GBX2_23144817_ChIP-Seq_PC3_Human3.63180642
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.25447892
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.23444822
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.15516948
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.86428551
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.86428551
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.78609054
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.77319574
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75422070
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64359958
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58375554
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.56253811
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55832538
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.55652040
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55408175
17DROSHA_22980978_ChIP-Seq_HELA_Human2.42527945
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.38038064
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28908246
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.27281552
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.27134482
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.25794361
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.22436230
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95668263
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91008158
26* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90649166
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90102692
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89227714
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77419425
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76250029
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74493519
32AR_21572438_ChIP-Seq_LNCaP_Human1.71380037
33TAF15_26573619_Chip-Seq_HEK293_Human1.65641345
34SMAD4_21799915_ChIP-Seq_A2780_Human1.64957694
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59836709
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.54623508
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53134162
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45863099
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44757026
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40558271
41P300_19829295_ChIP-Seq_ESCs_Human1.40471240
42ZNF274_21170338_ChIP-Seq_K562_Hela1.38991291
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.37150861
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32195125
45* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31419500
46GATA1_26923725_Chip-Seq_HPCs_Mouse1.30054506
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29793193
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28363656
49TET1_21490601_ChIP-Seq_MESCs_Mouse1.27559371
50CTCF_27219007_Chip-Seq_Bcells_Human1.27218020
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.25865900
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25862917
53* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25858448
54* AR_25329375_ChIP-Seq_VCAP_Human1.25575258
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.24839286
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24326257
57ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23968764
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23730206
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.21613327
60OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19314472
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17202050
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.16885369
63STAT3_23295773_ChIP-Seq_U87_Human1.16295775
64* AR_19668381_ChIP-Seq_PC3_Human1.16223499
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15336364
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.13284309
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13232960
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13178274
69* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11508069
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11442224
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09961653
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09841470
73RNF2_27304074_Chip-Seq_NSC_Mouse1.07895395
74IGF1R_20145208_ChIP-Seq_DFB_Human1.07750600
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.07522466
76VDR_22108803_ChIP-Seq_LS180_Human1.05574459
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04964177
78* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04373390
79SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04077414
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.03730465
81KDM2B_26808549_Chip-Seq_K562_Human1.01726886
82* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01579248
83TCF4_23295773_ChIP-Seq_U87_Human1.01120121
84FUS_26573619_Chip-Seq_HEK293_Human1.01089853
85TP53_16413492_ChIP-PET_HCT116_Human1.00388228
86* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99474676
87* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99321089
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99303472
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99190468
90* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98755129
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98711907
92AHR_22903824_ChIP-Seq_MCF-7_Human0.98536702
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97734827
94ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96960962
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96430027
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96430027
97* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95014259
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94491193
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94292811
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93532525
101* RUNX2_22187159_ChIP-Seq_PCA_Human0.93410826
102* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93089328
103TP53_18474530_ChIP-ChIP_U2OS_Human0.91749758
104* TP53_20018659_ChIP-ChIP_R1E_Mouse0.91577922
105* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91422414
106* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91302710
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90760909
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90743111
109JUN_21703547_ChIP-Seq_K562_Human0.90643374
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90543600
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90465657
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90461700
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.90196973
114* SMAD3_21741376_ChIP-Seq_ESCs_Human0.89173844
115* OCT4_19829295_ChIP-Seq_ESCs_Human0.87995637
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87721648
117DPY_21335234_ChIP-Seq_ESCs_Mouse0.87616212
118* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86146199
119RXR_22108803_ChIP-Seq_LS180_Human0.85363960
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82231844
121* SMC4_20622854_ChIP-Seq_HELA_Human0.78522373
122* KLF4_19829295_ChIP-Seq_ESCs_Human0.74570698
123* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74485839
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.74327829
125* SOX9_26525672_Chip-Seq_HEART_Mouse0.72576287
126RUNX1_26923725_Chip-Seq_HPCs_Mouse0.72142371
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71890761
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71435515
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.71362026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.10945251
2MP0003880_abnormal_central_pattern5.36049142
3MP0003635_abnormal_synaptic_transmissio4.34491813
4MP0004270_analgesia3.88321960
5MP0009745_abnormal_behavioral_response3.51408514
6MP0002063_abnormal_learning/memory/cond3.51107655
7MP0002064_seizures3.24728651
8MP0001968_abnormal_touch/_nociception3.08643209
9MP0009046_muscle_twitch2.94978787
10MP0002572_abnormal_emotion/affect_behav2.88974930
11MP0002734_abnormal_mechanical_nocicepti2.64413331
12MP0002272_abnormal_nervous_system2.64148985
13MP0002735_abnormal_chemical_nociception2.54854452
14MP0005423_abnormal_somatic_nervous2.53989530
15MP0001486_abnormal_startle_reflex2.50152189
16MP0002736_abnormal_nociception_after2.46173897
17MP0001501_abnormal_sleep_pattern2.44338810
18MP0001440_abnormal_grooming_behavior2.36832718
19MP0003329_amyloid_beta_deposits2.17946514
20MP0002733_abnormal_thermal_nociception2.05766412
21MP0004858_abnormal_nervous_system2.03344218
22MP0002067_abnormal_sensory_capabilities1.98144971
23MP0001970_abnormal_pain_threshold1.97439134
24MP0002184_abnormal_innervation1.95742703
25MP0000778_abnormal_nervous_system1.94017058
26MP0002822_catalepsy1.93881030
27MP0009780_abnormal_chondrocyte_physiolo1.90528824
28MP0008569_lethality_at_weaning1.81240288
29MP0004811_abnormal_neuron_physiology1.75383029
30MP0001984_abnormal_olfaction1.72989205
31MP0003879_abnormal_hair_cell1.70362317
32MP0002557_abnormal_social/conspecific_i1.70112720
33MP0003123_paternal_imprinting1.66608737
34MP0006276_abnormal_autonomic_nervous1.63495269
35MP0004924_abnormal_behavior1.58744039
36MP0005386_behavior/neurological_phenoty1.58744039
37MP0000955_abnormal_spinal_cord1.57491163
38MP0002909_abnormal_adrenal_gland1.51101929
39MP0002882_abnormal_neuron_morphology1.45575918
40MP0002066_abnormal_motor_capabilities/c1.41935672
41MP0003787_abnormal_imprinting1.33639637
42MP0004885_abnormal_endolymph1.32306035
43MP0003633_abnormal_nervous_system1.31783393
44MP0001502_abnormal_circadian_rhythm1.27535411
45MP0005646_abnormal_pituitary_gland1.23196877
46MP0001905_abnormal_dopamine_level1.21106883
47MP0005645_abnormal_hypothalamus_physiol1.19280733
48MP0008877_abnormal_DNA_methylation1.16111164
49MP0003631_nervous_system_phenotype1.14399902
50MP0002152_abnormal_brain_morphology1.11416487
51MP0010386_abnormal_urinary_bladder1.09461529
52MP0004145_abnormal_muscle_electrophysio1.09237024
53MP0004142_abnormal_muscle_tone1.07993912
54MP0000604_amyloidosis1.07453148
55MP0004510_myositis1.03130831
56MP0003121_genomic_imprinting1.00286395
57MP0004742_abnormal_vestibular_system0.96386211
58MP0003122_maternal_imprinting0.94659686
59MP0000751_myopathy0.94221743
60MP0002229_neurodegeneration0.92956503
61MP0002837_dystrophic_cardiac_calcinosis0.92906504
62MP0002069_abnormal_eating/drinking_beha0.92388463
63MP0005551_abnormal_eye_electrophysiolog0.92305084
64MP0008872_abnormal_physiological_respon0.91324545
65MP0008874_decreased_physiological_sensi0.89463392
66MP0001188_hyperpigmentation0.88274706
67MP0001963_abnormal_hearing_physiology0.87604896
68MP0001529_abnormal_vocalization0.87332791
69MP0005394_taste/olfaction_phenotype0.87264410
70MP0005499_abnormal_olfactory_system0.87264410
71MP0004484_altered_response_of0.86273637
72MP0003632_abnormal_nervous_system0.82970483
73MP0005535_abnormal_body_temperature0.82754920
74MP0002752_abnormal_somatic_nervous0.80849208
75MP0001986_abnormal_taste_sensitivity0.78866800
76MP0002876_abnormal_thyroid_physiology0.78537598
77MP0004085_abnormal_heartbeat0.78285624
78MP0004147_increased_porphyrin_level0.77857435
79MP0003634_abnormal_glial_cell0.77488738
80MP0001346_abnormal_lacrimal_gland0.74319951
81MP0010234_abnormal_vibrissa_follicle0.74269850
82MP0001177_atelectasis0.73525700
83MP0008961_abnormal_basal_metabolism0.72682013
84MP0000569_abnormal_digit_pigmentation0.72173953
85MP0004215_abnormal_myocardial_fiber0.70933761
86MP0000920_abnormal_myelination0.68494282
87MP0001485_abnormal_pinna_reflex0.67299979
88MP0002090_abnormal_vision0.67189425
89MP0001664_abnormal_digestion0.65547637
90* MP0003075_altered_response_to0.65411624
91MP0000013_abnormal_adipose_tissue0.65173219
92MP0001348_abnormal_lacrimal_gland0.64588523
93MP0000579_abnormal_nail_morphology0.63851903
94MP0003283_abnormal_digestive_organ0.63620343
95MP0003690_abnormal_glial_cell0.63490558
96MP0000631_abnormal_neuroendocrine_gland0.60530727
97MP0006292_abnormal_olfactory_placode0.60133413
98MP0003861_abnormal_nervous_system0.58618621
99MP0004233_abnormal_muscle_weight0.58374852
100MP0005623_abnormal_meninges_morphology0.58166561
101MP0010768_mortality/aging0.54777436
102MP0002082_postnatal_lethality0.54521330
103MP0004130_abnormal_muscle_cell0.54112489
104MP0000026_abnormal_inner_ear0.53903698
105MP0002638_abnormal_pupillary_reflex0.52973520
106MP0003938_abnormal_ear_development0.52441452
107MP0005187_abnormal_penis_morphology0.52414060
108MP0002653_abnormal_ependyma_morphology0.51781923
109MP0003137_abnormal_impulse_conducting0.51445649
110MP0003956_abnormal_body_size0.51123093
111MP0001943_abnormal_respiration0.50999920
112MP0005167_abnormal_blood-brain_barrier0.50537028
113MP0010769_abnormal_survival0.50534783
114MP0002234_abnormal_pharynx_morphology0.49403089
115MP0000566_synostosis0.48824230
116MP0010770_preweaning_lethality0.48322455
117MP0001299_abnormal_eye_distance/0.45881220
118MP0002873_normal_phenotype0.42491320

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.33187109
2Myokymia (HP:0002411)6.66142935
3Focal seizures (HP:0007359)6.20585623
4Visual hallucinations (HP:0002367)5.89626219
5Atonic seizures (HP:0010819)5.41410628
6Epileptic encephalopathy (HP:0200134)5.41069622
7Febrile seizures (HP:0002373)4.92840021
8Absence seizures (HP:0002121)4.72282320
9Dialeptic seizures (HP:0011146)4.38639931
10Progressive cerebellar ataxia (HP:0002073)4.33835633
11Generalized tonic-clonic seizures (HP:0002069)4.17854120
12Hyperventilation (HP:0002883)3.94447200
13Action tremor (HP:0002345)3.83381590
14Amblyopia (HP:0000646)3.79177148
15Supranuclear gaze palsy (HP:0000605)3.72223957
16Broad-based gait (HP:0002136)3.66106927
17Poor eye contact (HP:0000817)3.48944980
18Cerebral hypomyelination (HP:0006808)3.32126501
19Gaze-evoked nystagmus (HP:0000640)3.30013871
20Impaired vibration sensation in the lower limbs (HP:0002166)3.23105912
21Abnormality of the lower motor neuron (HP:0002366)3.22746215
22Cerebral inclusion bodies (HP:0100314)3.21332267
23Dysdiadochokinesis (HP:0002075)3.16916447
24Dysmetria (HP:0001310)3.15642490
25Depression (HP:0000716)3.13546147
26Impaired social interactions (HP:0000735)3.08100757
27Abnormal social behavior (HP:0012433)3.08100757
28Mutism (HP:0002300)3.01859272
29Truncal ataxia (HP:0002078)2.98231595
30Ankle clonus (HP:0011448)2.96457973
31Excessive salivation (HP:0003781)2.92801606
32Drooling (HP:0002307)2.92801606
33Akinesia (HP:0002304)2.91725064
34Neurofibrillary tangles (HP:0002185)2.90756274
35Urinary bladder sphincter dysfunction (HP:0002839)2.86868668
36Tetraplegia (HP:0002445)2.82794195
37Anxiety (HP:0000739)2.80521316
38Abnormal eating behavior (HP:0100738)2.77817122
39Hemiparesis (HP:0001269)2.72312358
40Genetic anticipation (HP:0003743)2.70914779
41Papilledema (HP:0001085)2.70151379
42Sleep apnea (HP:0010535)2.69713936
43Postural instability (HP:0002172)2.65554329
44Abnormality of binocular vision (HP:0011514)2.63691069
45Diplopia (HP:0000651)2.63691069
46Epileptiform EEG discharges (HP:0011182)2.63317994
47Peripheral hypomyelination (HP:0007182)2.62732338
48Absent speech (HP:0001344)2.61832067
49Impaired smooth pursuit (HP:0007772)2.60265056
50Insidious onset (HP:0003587)2.57548575
51Termporal pattern (HP:0011008)2.57548575
52Urinary urgency (HP:0000012)2.56086815
53Stereotypic behavior (HP:0000733)2.55826604
54Clonus (HP:0002169)2.55182828
55Progressive inability to walk (HP:0002505)2.50970448
56EEG with generalized epileptiform discharges (HP:0011198)2.46993684
57Inability to walk (HP:0002540)2.43699598
58Status epilepticus (HP:0002133)2.43021493
59Scanning speech (HP:0002168)2.40912126
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39927207
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.39927207
62Abnormality of the corticospinal tract (HP:0002492)2.38485151
63Generalized myoclonic seizures (HP:0002123)2.37754600
64Fetal akinesia sequence (HP:0001989)2.37260489
65Spastic gait (HP:0002064)2.36086928
66Bradykinesia (HP:0002067)2.34245560
67Intention tremor (HP:0002080)2.31082077
68Hypsarrhythmia (HP:0002521)2.28338748
69Amyotrophic lateral sclerosis (HP:0007354)2.27730634
70Abnormality of ocular smooth pursuit (HP:0000617)2.25991327
71Delusions (HP:0000746)2.25302654
72Morphological abnormality of the pyramidal tract (HP:0002062)2.25147433
73Hemiplegia (HP:0002301)2.19989029
74Torticollis (HP:0000473)2.18255682
75Megalencephaly (HP:0001355)2.16749424
76Impaired vibratory sensation (HP:0002495)2.15454016
77CNS hypomyelination (HP:0003429)2.15098730
78Spastic tetraparesis (HP:0001285)2.15061189
79Focal dystonia (HP:0004373)2.13067979
80Ventricular fibrillation (HP:0001663)2.11421191
81Rigidity (HP:0002063)2.10546882
82Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.10313092
83Inappropriate behavior (HP:0000719)2.06301098
84Rapidly progressive (HP:0003678)2.05235311
85Lower limb muscle weakness (HP:0007340)2.04618472
86Dysmetric saccades (HP:0000641)2.02205841
87Obstructive sleep apnea (HP:0002870)2.01705576
88Agitation (HP:0000713)2.00650333
89Abnormality of salivation (HP:0100755)2.00267470
90Protruding tongue (HP:0010808)1.99347045
91Lower limb asymmetry (HP:0100559)1.96476996
92Choreoathetosis (HP:0001266)1.95482575
93Annular pancreas (HP:0001734)1.95424854
94Gait ataxia (HP:0002066)1.95145811
95Polyphagia (HP:0002591)1.94861318
96Apathy (HP:0000741)1.94259503
97Retinal dysplasia (HP:0007973)1.92012312
98Split foot (HP:0001839)1.91039119
99Incomplete penetrance (HP:0003829)1.90644720
100Pheochromocytoma (HP:0002666)1.89501032
101Spastic tetraplegia (HP:0002510)1.89437076
102Psychosis (HP:0000709)1.86500494
103Neuronal loss in central nervous system (HP:0002529)1.82485067
104Blue irides (HP:0000635)1.82406657
105Pointed chin (HP:0000307)1.80776186
106Thickened helices (HP:0000391)1.78627646
107Craniofacial dystonia (HP:0012179)1.78041716
108Hyperthyroidism (HP:0000836)1.76254580
109Unsteady gait (HP:0002317)1.74407200
110Hypoventilation (HP:0002791)1.73368941
111Gait imbalance (HP:0002141)1.70588391
112Insomnia (HP:0100785)1.70221433
113Lower limb amyotrophy (HP:0007210)1.69637209
114Diminished motivation (HP:0000745)1.69501884
115Paraplegia (HP:0010550)1.68591325
116Hypoplasia of the corpus callosum (HP:0002079)1.68262496
117Type II lissencephaly (HP:0007260)1.67812806
118Increased circulating renin level (HP:0000848)1.67795061
119Abnormality of saccadic eye movements (HP:0000570)1.66732037
120Limb dystonia (HP:0002451)1.66386220
121Specific learning disability (HP:0001328)1.65370645
122Spinal canal stenosis (HP:0003416)1.64207583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.71272129
2EPHA44.55990625
3MAP3K93.99338393
4DAPK22.81436326
5MAP3K42.80694171
6RIPK42.76099352
7MINK12.65406323
8MARK12.62318221
9KSR22.38051571
10MAP2K72.36890747
11PAK62.26907170
12MAP3K122.10017676
13PLK21.93354694
14MAP2K41.92212490
15GRK51.88081160
16KSR11.85579331
17CASK1.85113581
18ARAF1.79978346
19DAPK11.79469330
20NTRK11.78552643
21NTRK21.76708471
22PNCK1.74989996
23PRPF4B1.74072381
24PRKD31.71109414
25CAMKK11.64843153
26SIK21.64453348
27MAP3K131.52782979
28CDK51.49548726
29CDK191.40685997
30TNIK1.27594903
31PRKCG1.27207694
32STK381.25953894
33PTK2B1.23169346
34MAPK131.19539148
35MAP3K21.15254123
36BMPR21.14011884
37FES1.09055461
38RAF11.05158383
39CAMK2A1.04526096
40TYRO31.03358569
41CAMKK21.00569449
42CAMK11.00199453
43LATS20.98851019
44UHMK10.93383031
45NEK60.91522756
46NME10.87004747
47CAMK2B0.86215543
48CDK180.86201842
49CDK140.85544748
50PHKG10.85125325
51PHKG20.85125325
52CDK150.84489239
53BRSK10.83193446
54MAP3K110.81899601
55RIPK10.81623190
56PKN10.81544033
57DYRK1A0.79188793
58PAK30.78416194
59STK110.76305895
60FGR0.74360362
61CDK11A0.73899089
62CCNB10.72472162
63RET0.72155766
64OXSR10.70406263
65LIMK10.69525490
66SGK4940.66547371
67SGK2230.66547371
68PDK10.64168337
69TAOK10.63787921
70SGK10.63698723
71CAMK1D0.63068559
72PRKCH0.62237318
73PDPK10.59996078
74MAP3K10.59828623
75PINK10.58488820
76MARK20.55928042
77DYRK20.55724343
78CSNK1G20.54242906
79TESK10.52449285
80ALK0.50735767
81CAMK2D0.50283127
82CAMK1G0.50089505
83DAPK30.48998837
84MAP2K10.48338327
85MOS0.48172928
86PRKCZ0.48147820
87PRKCE0.47998676
88SGK20.47086735
89MAP3K70.46623447
90FER0.46298124
91MAPK120.45232801
92CAMK40.44593303
93MAP3K60.44551048
94BRAF0.42617567
95CAMK2G0.42283574
96LMTK20.41597773
97GRK60.41333271
98RPS6KA30.40151794
99FYN0.38805460
100MAPK100.37749953
101SGK30.37589598
102ROCK20.35185272
103CSNK1E0.34799264
104TNK20.34506636
105DMPK0.34323352
106IRAK20.30562931
107ERBB20.29785221
108PRKACA0.29283551
109MAPK80.28165716
110CDC42BPA0.26274520
111CSNK1G30.26214986
112WNK10.26106108
113PRKCA0.26053453
114PRKCB0.25666643
115CSNK1D0.25574640
116GSK3B0.24939753
117PRKG10.24403584
118MUSK0.24214306
119FGFR20.23772424
120WNK30.21471448

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.80880226
2Synaptic vesicle cycle_Homo sapiens_hsa047213.24812665
3Long-term potentiation_Homo sapiens_hsa047202.94241623
4Olfactory transduction_Homo sapiens_hsa047402.79517528
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.76462030
6Circadian entrainment_Homo sapiens_hsa047132.72605629
7Glutamatergic synapse_Homo sapiens_hsa047242.67495118
8GABAergic synapse_Homo sapiens_hsa047272.55222360
9Amphetamine addiction_Homo sapiens_hsa050312.47867925
10Morphine addiction_Homo sapiens_hsa050322.38635458
11Salivary secretion_Homo sapiens_hsa049702.29580563
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27821878
13Dopaminergic synapse_Homo sapiens_hsa047282.12376326
14Insulin secretion_Homo sapiens_hsa049111.96382260
15Gastric acid secretion_Homo sapiens_hsa049711.94076867
16Taste transduction_Homo sapiens_hsa047421.87831003
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84468137
18Cholinergic synapse_Homo sapiens_hsa047251.83384439
19Long-term depression_Homo sapiens_hsa047301.81706783
20Oxytocin signaling pathway_Homo sapiens_hsa049211.75605064
21Renin secretion_Homo sapiens_hsa049241.73057885
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66480157
23Calcium signaling pathway_Homo sapiens_hsa040201.65592372
24Collecting duct acid secretion_Homo sapiens_hsa049661.65097811
25Serotonergic synapse_Homo sapiens_hsa047261.65089538
26GnRH signaling pathway_Homo sapiens_hsa049121.55379502
27Vitamin B6 metabolism_Homo sapiens_hsa007501.51279800
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40178642
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37164835
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35495429
31Gap junction_Homo sapiens_hsa045401.31516972
32Cocaine addiction_Homo sapiens_hsa050301.28389868
33cAMP signaling pathway_Homo sapiens_hsa040241.27688724
34Glioma_Homo sapiens_hsa052141.20749819
35Estrogen signaling pathway_Homo sapiens_hsa049151.17322631
36Axon guidance_Homo sapiens_hsa043601.15600997
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15472837
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10348245
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09878939
40Melanogenesis_Homo sapiens_hsa049161.09359918
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07905725
42Type II diabetes mellitus_Homo sapiens_hsa049301.05578251
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04031577
44Cardiac muscle contraction_Homo sapiens_hsa042601.01779778
45ErbB signaling pathway_Homo sapiens_hsa040121.01706912
46Vibrio cholerae infection_Homo sapiens_hsa051101.01560478
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00615148
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99262180
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96581144
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.94653468
51Phototransduction_Homo sapiens_hsa047440.92158591
52Oocyte meiosis_Homo sapiens_hsa041140.91985824
53Pancreatic secretion_Homo sapiens_hsa049720.87863724
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.85462010
55Dorso-ventral axis formation_Homo sapiens_hsa043200.85251158
56VEGF signaling pathway_Homo sapiens_hsa043700.82802684
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80530993
58Choline metabolism in cancer_Homo sapiens_hsa052310.79754383
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79026576
60Thyroid hormone synthesis_Homo sapiens_hsa049180.76501542
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74279444
62MAPK signaling pathway_Homo sapiens_hsa040100.69350150
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68424044
64Dilated cardiomyopathy_Homo sapiens_hsa054140.67616189
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.64647917
66Glucagon signaling pathway_Homo sapiens_hsa049220.59409402
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59291379
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.57545414
69Ras signaling pathway_Homo sapiens_hsa040140.56952661
70African trypanosomiasis_Homo sapiens_hsa051430.55183783
71Alzheimers disease_Homo sapiens_hsa050100.55161437
72Rap1 signaling pathway_Homo sapiens_hsa040150.54394246
73SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52439611
74mTOR signaling pathway_Homo sapiens_hsa041500.49372958
75Inositol phosphate metabolism_Homo sapiens_hsa005620.48643169
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45698559
77Nitrogen metabolism_Homo sapiens_hsa009100.44427715
78Wnt signaling pathway_Homo sapiens_hsa043100.44273750
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44183070
80Prion diseases_Homo sapiens_hsa050200.44012342
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43506392
82Endocytosis_Homo sapiens_hsa041440.43354705
83Bile secretion_Homo sapiens_hsa049760.40979927
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40620320
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40332457
86Arginine and proline metabolism_Homo sapiens_hsa003300.39897881
87Arginine biosynthesis_Homo sapiens_hsa002200.38962747
88Type I diabetes mellitus_Homo sapiens_hsa049400.38732571
89Non-small cell lung cancer_Homo sapiens_hsa052230.38518676
90Renal cell carcinoma_Homo sapiens_hsa052110.37991667
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36821434
92Alcoholism_Homo sapiens_hsa050340.36371269
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36246504
94Endometrial cancer_Homo sapiens_hsa052130.35055056
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34582431
96Circadian rhythm_Homo sapiens_hsa047100.34282356
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34052088
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33234803
99Insulin signaling pathway_Homo sapiens_hsa049100.33211505
100Chemokine signaling pathway_Homo sapiens_hsa040620.31894829
101Fatty acid biosynthesis_Homo sapiens_hsa000610.30449399
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30105613
103Regulation of autophagy_Homo sapiens_hsa041400.29792682
104Ovarian steroidogenesis_Homo sapiens_hsa049130.29506572
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27394411
106Oxidative phosphorylation_Homo sapiens_hsa001900.27340933
107Rheumatoid arthritis_Homo sapiens_hsa053230.27321643
108AMPK signaling pathway_Homo sapiens_hsa041520.26178288
109Parkinsons disease_Homo sapiens_hsa050120.25651931
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25507237
111Hippo signaling pathway_Homo sapiens_hsa043900.23568629
112Tight junction_Homo sapiens_hsa045300.21607594
113Mineral absorption_Homo sapiens_hsa049780.20759888
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18755509
115Histidine metabolism_Homo sapiens_hsa003400.18192801

Most similar genes based on co-expression Upload to Enrichr

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