

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | vocalization behavior (GO:0071625) | 5.77504903 |
| 2 | synaptic vesicle exocytosis (GO:0016079) | 5.72863850 |
| 3 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.60496695 |
| 4 | locomotory exploration behavior (GO:0035641) | 5.46643385 |
| 5 | neuronal action potential propagation (GO:0019227) | 5.27661006 |
| 6 | glutamate secretion (GO:0014047) | 5.08865557 |
| 7 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.06844550 |
| 8 | neurotransmitter secretion (GO:0007269) | 5.05457951 |
| 9 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 5.03491316 |
| 10 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.03304599 |
| 11 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.00721814 |
| 12 | positive regulation of amino acid transport (GO:0051957) | 4.99852226 |
| 13 | neuron cell-cell adhesion (GO:0007158) | 4.94303580 |
| 14 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.86196358 |
| 15 | gamma-aminobutyric acid transport (GO:0015812) | 4.82474444 |
| 16 | synaptic vesicle maturation (GO:0016188) | 4.81631883 |
| 17 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.79805565 |
| 18 | cerebellar granule cell differentiation (GO:0021707) | 4.79761523 |
| 19 | negative regulation of amino acid transport (GO:0051956) | 4.74969494 |
| 20 | glutamate receptor signaling pathway (GO:0007215) | 4.69978715 |
| 21 | neuron-neuron synaptic transmission (GO:0007270) | 4.62023314 |
| 22 | synaptic transmission, glutamatergic (GO:0035249) | 4.58617622 |
| 23 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 4.52617689 |
| 24 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.50361843 |
| 25 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.33427197 |
| 26 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.32869046 |
| 27 | regulation of synaptic vesicle transport (GO:1902803) | 4.28367952 |
| 28 | exploration behavior (GO:0035640) | 4.27342946 |
| 29 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.25197996 |
| 30 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 4.17149873 |
| 31 | neurotransmitter transport (GO:0006836) | 4.13937266 |
| 32 | protein localization to synapse (GO:0035418) | 4.11279507 |
| 33 | cerebellar Purkinje cell differentiation (GO:0021702) | 4.10997218 |
| 34 | regulation of feeding behavior (GO:0060259) | 4.10826342 |
| 35 | serotonin receptor signaling pathway (GO:0007210) | 4.02126089 |
| 36 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.98268527 |
| 37 | positive regulation of synapse maturation (GO:0090129) | 3.96210918 |
| 38 | regulation of neurotransmitter levels (GO:0001505) | 3.91326395 |
| 39 | long-term memory (GO:0007616) | 3.87695884 |
| 40 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.87152066 |
| 41 | neuronal ion channel clustering (GO:0045161) | 3.85599342 |
| 42 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.85371462 |
| 43 | cellular potassium ion homeostasis (GO:0030007) | 3.80172380 |
| 44 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.76498951 |
| 45 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.75156733 |
| 46 | neuromuscular process controlling posture (GO:0050884) | 3.66838715 |
| 47 | transmission of nerve impulse (GO:0019226) | 3.63414175 |
| 48 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.61412171 |
| 49 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.60882029 |
| 50 | long-term synaptic potentiation (GO:0060291) | 3.60680782 |
| 51 | regulation of phospholipid biosynthetic process (GO:0071071) | 3.59654203 |
| 52 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.58531720 |
| 53 | regulation of postsynaptic membrane potential (GO:0060078) | 3.58360437 |
| 54 | presynaptic membrane assembly (GO:0097105) | 3.57898772 |
| 55 | proline transport (GO:0015824) | 3.56870782 |
| 56 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.56850441 |
| 57 | response to pheromone (GO:0019236) | 3.55513065 |
| 58 | serotonin metabolic process (GO:0042428) | 3.54322762 |
| 59 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.54071524 |
| 60 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.50921561 |
| 61 | postsynaptic membrane organization (GO:0001941) | 3.48922483 |
| 62 | presynaptic membrane organization (GO:0097090) | 3.48485115 |
| 63 | layer formation in cerebral cortex (GO:0021819) | 3.46965669 |
| 64 | positive regulation of synapse assembly (GO:0051965) | 3.46762252 |
| 65 | response to histamine (GO:0034776) | 3.46495467 |
| 66 | positive regulation of membrane potential (GO:0045838) | 3.43945953 |
| 67 | startle response (GO:0001964) | 3.43505811 |
| 68 | cell differentiation in hindbrain (GO:0021533) | 3.42006692 |
| 69 | synaptic vesicle endocytosis (GO:0048488) | 3.39750778 |
| 70 | neuron recognition (GO:0008038) | 3.38902013 |
| 71 | short-term memory (GO:0007614) | 3.38237138 |
| 72 | dendritic spine morphogenesis (GO:0060997) | 3.36994618 |
| 73 | regulation of synapse structural plasticity (GO:0051823) | 3.36491090 |
| 74 | activation of protein kinase A activity (GO:0034199) | 3.34053178 |
| 75 | regulation of neurotransmitter secretion (GO:0046928) | 3.32023690 |
| 76 | nucleobase catabolic process (GO:0046113) | 3.28762740 |
| 77 | positive regulation of amine transport (GO:0051954) | 3.28202596 |
| 78 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.28077437 |
| 79 | behavioral response to cocaine (GO:0048148) | 3.27869677 |
| 80 | sodium ion export (GO:0071436) | 3.25833752 |
| 81 | regulation of synapse maturation (GO:0090128) | 3.25729517 |
| 82 | membrane hyperpolarization (GO:0060081) | 3.24591508 |
| 83 | synapse assembly (GO:0007416) | 3.23250850 |
| 84 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.22672752 |
| 85 | membrane depolarization (GO:0051899) | 3.22377428 |
| 86 | regulation of vesicle fusion (GO:0031338) | 3.19182256 |
| 87 | behavioral defense response (GO:0002209) | 3.17851907 |
| 88 | behavioral fear response (GO:0001662) | 3.17851907 |
| 89 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.17757440 |
| 90 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.17757440 |
| 91 | primary amino compound metabolic process (GO:1901160) | 3.16903411 |
| 92 | retinal ganglion cell axon guidance (GO:0031290) | 3.16680577 |
| 93 | regulation of synaptic plasticity (GO:0048167) | 3.16196891 |
| 94 | regulation of neurotransmitter transport (GO:0051588) | 3.15112888 |
| 95 | synaptic transmission (GO:0007268) | 3.13544124 |
| 96 | membrane depolarization during action potential (GO:0086010) | 3.13491707 |
| 97 | prepulse inhibition (GO:0060134) | 3.12970284 |
| 98 | dendrite morphogenesis (GO:0048813) | 3.12704471 |
| 99 | adult walking behavior (GO:0007628) | 3.10820148 |
| 100 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.10248389 |
| 101 | striatum development (GO:0021756) | 3.09493265 |
| 102 | regulation of synaptic transmission, GABAergic (GO:0032228) | 3.09276952 |
| 103 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.07867784 |
| 104 | fear response (GO:0042596) | 3.07375854 |
| 105 | auditory behavior (GO:0031223) | 3.05979297 |
| 106 | imidazole-containing compound metabolic process (GO:0052803) | 3.05134768 |
| 107 | mechanosensory behavior (GO:0007638) | 3.04109262 |
| 108 | regulation of glutamate secretion (GO:0014048) | 3.02322059 |
| 109 | mating behavior (GO:0007617) | 3.00308801 |
| 110 | regulation of amino acid transport (GO:0051955) | 3.00227575 |
| 111 | response to amphetamine (GO:0001975) | 3.00105802 |
| 112 | social behavior (GO:0035176) | 2.99768438 |
| 113 | intraspecies interaction between organisms (GO:0051703) | 2.99768438 |
| 114 | positive regulation of synaptic transmission (GO:0050806) | 2.98355575 |
| 115 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.96159609 |
| 116 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.95858531 |
| 117 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.95558603 |
| 118 | establishment of synaptic vesicle localization (GO:0097480) | 2.94258615 |
| 119 | synaptic vesicle transport (GO:0048489) | 2.94258615 |
| 120 | regulation of synaptic transmission (GO:0050804) | 2.94031598 |
| 121 | neuromuscular process controlling balance (GO:0050885) | 2.93588681 |
| 122 | axonal fasciculation (GO:0007413) | 2.92736349 |
| 123 | transferrin transport (GO:0033572) | 2.90619626 |
| 124 | adult behavior (GO:0030534) | 2.89697841 |
| 125 | regulation of appetite (GO:0032098) | 2.87476459 |
| 126 | positive regulation of dendritic spine development (GO:0060999) | 2.86283376 |
| 127 | neuromuscular synaptic transmission (GO:0007274) | 2.83789182 |
| 128 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.83772485 |
| 129 | response to auditory stimulus (GO:0010996) | 2.82116510 |
| 130 | axon extension involved in axon guidance (GO:0048846) | 2.81523203 |
| 131 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.81523203 |
| 132 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G- | 2.81015569 |
| 133 | cGMP metabolic process (GO:0046068) | 2.80077013 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.10951248 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.88591786 |
| 3 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.18094927 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.15728685 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.98849749 |
| 6 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.74418714 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.65631555 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.65631555 |
| 9 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.62979262 |
| 10 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.54067995 |
| 11 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.53616224 |
| 12 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.51364906 |
| 13 | * TAF15_26573619_Chip-Seq_HEK293_Human | 2.50163685 |
| 14 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.46487029 |
| 15 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.44452194 |
| 16 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.43190179 |
| 17 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.37972079 |
| 18 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.35558071 |
| 19 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.32549618 |
| 20 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.23275780 |
| 21 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.20584223 |
| 22 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.16735846 |
| 23 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.15283804 |
| 24 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.13482289 |
| 25 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.11813834 |
| 26 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.06598322 |
| 27 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.97333208 |
| 28 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.97157084 |
| 29 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.91528289 |
| 30 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.89338115 |
| 31 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.89144331 |
| 32 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.86769891 |
| 33 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.82922166 |
| 34 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.79618453 |
| 35 | * ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.72386005 |
| 36 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.69683905 |
| 37 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.66391397 |
| 38 | P300_19829295_ChIP-Seq_ESCs_Human | 1.61773418 |
| 39 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.58808867 |
| 40 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.56786335 |
| 41 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.54790425 |
| 42 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.52462474 |
| 43 | EWS_26573619_Chip-Seq_HEK293_Human | 1.51623209 |
| 44 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.50888937 |
| 45 | * BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.46655655 |
| 46 | * POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.41550592 |
| 47 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.40924813 |
| 48 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.40368172 |
| 49 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.39182447 |
| 50 | AR_25329375_ChIP-Seq_VCAP_Human | 1.37979127 |
| 51 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.36751424 |
| 52 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.36694767 |
| 53 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.36555128 |
| 54 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.36373996 |
| 55 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.35242022 |
| 56 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.32477122 |
| 57 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.32343655 |
| 58 | * OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.30823084 |
| 59 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.28365972 |
| 60 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.27600508 |
| 61 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.27279268 |
| 62 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.27170381 |
| 63 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.27156127 |
| 64 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.26600168 |
| 65 | * CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.26543664 |
| 66 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.22334670 |
| 67 | * RNF2_27304074_Chip-Seq_NSC_Mouse | 1.22117355 |
| 68 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.21400310 |
| 69 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.21386349 |
| 70 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.18416280 |
| 71 | * AR_19668381_ChIP-Seq_PC3_Human | 1.18249550 |
| 72 | TCF4_23295773_ChIP-Seq_U87_Human | 1.17752281 |
| 73 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.17246089 |
| 74 | FUS_26573619_Chip-Seq_HEK293_Human | 1.17158193 |
| 75 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.14253396 |
| 76 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.13256080 |
| 77 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.11935981 |
| 78 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.11817171 |
| 79 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.11476987 |
| 80 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.11389882 |
| 81 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.11107921 |
| 82 | * LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.10823473 |
| 83 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.10153320 |
| 84 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.10103946 |
| 85 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.10094537 |
| 86 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.08568162 |
| 87 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.07887456 |
| 88 | VDR_22108803_ChIP-Seq_LS180_Human | 1.06482699 |
| 89 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.05161373 |
| 90 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.03799432 |
| 91 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03400434 |
| 92 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.00761001 |
| 93 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.00714526 |
| 94 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.98485194 |
| 95 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.98377430 |
| 96 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.95336849 |
| 97 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.95082343 |
| 98 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.94823982 |
| 99 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.94434999 |
| 100 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.93762705 |
| 101 | * NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.93047882 |
| 102 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.92658969 |
| 103 | JUN_21703547_ChIP-Seq_K562_Human | 0.91916824 |
| 104 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 0.91228257 |
| 105 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.91173936 |
| 106 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.91094468 |
| 107 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.90665630 |
| 108 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.90665630 |
| 109 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.90566590 |
| 110 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.89018744 |
| 111 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.88728583 |
| 112 | TP53_16413492_ChIP-PET_HCT116_Human | 0.88643718 |
| 113 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.86617581 |
| 114 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.86476443 |
| 115 | KDM2B_26808549_Chip-Seq_REH_Human | 0.84818724 |
| 116 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.84386457 |
| 117 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.84238969 |
| 118 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.83952028 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.36949445 |
| 2 | MP0003880_abnormal_central_pattern | 4.84489179 |
| 3 | MP0009046_muscle_twitch | 4.17945991 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 4.11250723 |
| 5 | MP0009745_abnormal_behavioral_response | 3.59931229 |
| 6 | MP0002064_seizures | 3.46559714 |
| 7 | MP0002063_abnormal_learning/memory/cond | 3.14698443 |
| 8 | MP0001968_abnormal_touch/_nociception | 3.06789048 |
| 9 | MP0004270_analgesia | 3.06475665 |
| 10 | MP0002272_abnormal_nervous_system | 2.96025001 |
| 11 | MP0002572_abnormal_emotion/affect_behav | 2.91513215 |
| 12 | MP0005423_abnormal_somatic_nervous | 2.66697850 |
| 13 | MP0002736_abnormal_nociception_after | 2.66565925 |
| 14 | MP0001501_abnormal_sleep_pattern | 2.65594358 |
| 15 | MP0000372_irregular_coat_pigmentation | 2.64252977 |
| 16 | MP0002822_catalepsy | 2.63615033 |
| 17 | MP0002734_abnormal_mechanical_nocicepti | 2.61850721 |
| 18 | MP0000566_synostosis | 2.50170146 |
| 19 | MP0001440_abnormal_grooming_behavior | 2.45731193 |
| 20 | MP0001486_abnormal_startle_reflex | 2.42294924 |
| 21 | MP0002735_abnormal_chemical_nociception | 2.35050573 |
| 22 | MP0002067_abnormal_sensory_capabilities | 2.32422254 |
| 23 | MP0010030_abnormal_orbit_morphology | 2.21707314 |
| 24 | MP0008569_lethality_at_weaning | 2.18211795 |
| 25 | MP0002733_abnormal_thermal_nociception | 2.03132645 |
| 26 | MP0004142_abnormal_muscle_tone | 2.02897425 |
| 27 | MP0006276_abnormal_autonomic_nervous | 2.02220303 |
| 28 | MP0000579_abnormal_nail_morphology | 2.00620105 |
| 29 | MP0001970_abnormal_pain_threshold | 1.97495090 |
| 30 | MP0002184_abnormal_innervation | 1.95485974 |
| 31 | MP0005386_behavior/neurological_phenoty | 1.93248906 |
| 32 | MP0004924_abnormal_behavior | 1.93248906 |
| 33 | MP0003122_maternal_imprinting | 1.86237372 |
| 34 | MP0002557_abnormal_social/conspecific_i | 1.84558302 |
| 35 | MP0005646_abnormal_pituitary_gland | 1.73958591 |
| 36 | MP0003787_abnormal_imprinting | 1.71619915 |
| 37 | MP0001346_abnormal_lacrimal_gland | 1.66705712 |
| 38 | MP0003329_amyloid_beta_deposits | 1.64433109 |
| 39 | MP0001529_abnormal_vocalization | 1.63280091 |
| 40 | MP0009780_abnormal_chondrocyte_physiolo | 1.59449564 |
| 41 | MP0002909_abnormal_adrenal_gland | 1.59224378 |
| 42 | MP0003879_abnormal_hair_cell | 1.56491414 |
| 43 | MP0005645_abnormal_hypothalamus_physiol | 1.55594432 |
| 44 | MP0002066_abnormal_motor_capabilities/c | 1.49948948 |
| 45 | MP0003011_delayed_dark_adaptation | 1.47069519 |
| 46 | MP0004811_abnormal_neuron_physiology | 1.46163844 |
| 47 | MP0000955_abnormal_spinal_cord | 1.44243127 |
| 48 | MP0002837_dystrophic_cardiac_calcinosis | 1.44055772 |
| 49 | MP0001984_abnormal_olfaction | 1.42679893 |
| 50 | MP0003136_yellow_coat_color | 1.42204171 |
| 51 | MP0000778_abnormal_nervous_system | 1.42141156 |
| 52 | MP0004145_abnormal_muscle_electrophysio | 1.34697756 |
| 53 | MP0001905_abnormal_dopamine_level | 1.34385093 |
| 54 | MP0001188_hyperpigmentation | 1.30353010 |
| 55 | MP0002102_abnormal_ear_morphology | 1.28805775 |
| 56 | MP0002882_abnormal_neuron_morphology | 1.27350148 |
| 57 | MP0004885_abnormal_endolymph | 1.26492807 |
| 58 | MP0003633_abnormal_nervous_system | 1.26184259 |
| 59 | MP0001502_abnormal_circadian_rhythm | 1.25999696 |
| 60 | MP0005171_absent_coat_pigmentation | 1.24784350 |
| 61 | MP0008961_abnormal_basal_metabolism | 1.22659113 |
| 62 | MP0006292_abnormal_olfactory_placode | 1.22463673 |
| 63 | MP0000013_abnormal_adipose_tissue | 1.18119522 |
| 64 | MP0004858_abnormal_nervous_system | 1.17379709 |
| 65 | MP0008872_abnormal_physiological_respon | 1.16492707 |
| 66 | MP0003631_nervous_system_phenotype | 1.14784176 |
| 67 | MP0004742_abnormal_vestibular_system | 1.10219845 |
| 68 | MP0002295_abnormal_pulmonary_circulatio | 1.05517132 |
| 69 | MP0004043_abnormal_pH_regulation | 1.04682347 |
| 70 | MP0002234_abnormal_pharynx_morphology | 1.04408699 |
| 71 | MP0003632_abnormal_nervous_system | 1.01749947 |
| 72 | MP0002152_abnormal_brain_morphology | 1.00235400 |
| 73 | MP0003938_abnormal_ear_development | 0.96863594 |
| 74 | MP0002069_abnormal_eating/drinking_beha | 0.96794480 |
| 75 | MP0002229_neurodegeneration | 0.96144236 |
| 76 | MP0002876_abnormal_thyroid_physiology | 0.95399861 |
| 77 | MP0005253_abnormal_eye_physiology | 0.95000752 |
| 78 | MP0003942_abnormal_urinary_system | 0.94934427 |
| 79 | MP0005535_abnormal_body_temperature | 0.94580952 |
| 80 | MP0000751_myopathy | 0.94015739 |
| 81 | MP0002751_abnormal_autonomic_nervous | 0.93830216 |
| 82 | MP0004215_abnormal_myocardial_fiber | 0.93676320 |
| 83 | MP0008874_decreased_physiological_sensi | 0.93437014 |
| 84 | MP0005551_abnormal_eye_electrophysiolog | 0.92426764 |
| 85 | MP0003646_muscle_fatigue | 0.90614432 |
| 86 | MP0001293_anophthalmia | 0.89380900 |
| 87 | MP0002938_white_spotting | 0.88298951 |
| 88 | MP0000026_abnormal_inner_ear | 0.86483471 |
| 89 | MP0001324_abnormal_eye_pigmentation | 0.86430269 |
| 90 | MP0003690_abnormal_glial_cell | 0.83370238 |
| 91 | MP0008789_abnormal_olfactory_epithelium | 0.81802068 |
| 92 | MP0004085_abnormal_heartbeat | 0.81245570 |
| 93 | MP0010386_abnormal_urinary_bladder | 0.81174985 |
| 94 | MP0001963_abnormal_hearing_physiology | 0.80974308 |
| 95 | MP0003861_abnormal_nervous_system | 0.80564854 |
| 96 | MP0003937_abnormal_limbs/digits/tail_de | 0.79457836 |
| 97 | MP0004484_altered_response_of | 0.79244737 |
| 98 | MP0003890_abnormal_embryonic-extraembry | 0.78356658 |
| 99 | MP0000537_abnormal_urethra_morphology | 0.78142396 |
| 100 | MP0002233_abnormal_nose_morphology | 0.77789824 |
| 101 | MP0001177_atelectasis | 0.73038157 |
| 102 | MP0000604_amyloidosis | 0.72704440 |
| 103 | MP0003183_abnormal_peptide_metabolism | 0.71450577 |
| 104 | MP0004233_abnormal_muscle_weight | 0.71296343 |
| 105 | MP0004133_heterotaxia | 0.69110302 |
| 106 | MP0002653_abnormal_ependyma_morphology | 0.68220551 |
| 107 | MP0003634_abnormal_glial_cell | 0.66462691 |
| 108 | MP0002752_abnormal_somatic_nervous | 0.66289154 |
| 109 | MP0002928_abnormal_bile_duct | 0.66095493 |
| 110 | MP0005084_abnormal_gallbladder_morpholo | 0.66001128 |
| 111 | MP0000920_abnormal_myelination | 0.65462826 |
| 112 | MP0000631_abnormal_neuroendocrine_gland | 0.64978489 |
| 113 | MP0001664_abnormal_digestion | 0.64498842 |
| 114 | MP0003121_genomic_imprinting | 0.61998309 |
| 115 | MP0002638_abnormal_pupillary_reflex | 0.59424182 |
| 116 | MP0002090_abnormal_vision | 0.59041377 |
| 117 | MP0004147_increased_porphyrin_level | 0.58809300 |
| 118 | MP0005499_abnormal_olfactory_system | 0.58709056 |
| 119 | MP0005394_taste/olfaction_phenotype | 0.58709056 |
| 120 | MP0001943_abnormal_respiration | 0.58546684 |
| 121 | MP0003137_abnormal_impulse_conducting | 0.55813038 |
| 122 | MP0002082_postnatal_lethality | 0.54892210 |
| 123 | MP0010770_preweaning_lethality | 0.54892210 |
| 124 | MP0010769_abnormal_survival | 0.53553285 |
| 125 | MP0010768_mortality/aging | 0.50344330 |
| 126 | MP0003956_abnormal_body_size | 0.50199013 |
| 127 | MP0008877_abnormal_DNA_methylation | 0.50086360 |
| 128 | MP0003123_paternal_imprinting | 0.49968585 |
| 129 | MP0001299_abnormal_eye_distance/ | 0.49557930 |
| 130 | MP0002332_abnormal_exercise_endurance | 0.49271160 |
| 131 | MP0006035_abnormal_mitochondrial_morpho | 0.48795400 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.83464472 |
| 2 | Atonic seizures (HP:0010819) | 5.97153613 |
| 3 | Focal seizures (HP:0007359) | 5.90504574 |
| 4 | Visual hallucinations (HP:0002367) | 5.50703852 |
| 5 | Myokymia (HP:0002411) | 5.42391721 |
| 6 | Febrile seizures (HP:0002373) | 5.12604086 |
| 7 | Progressive cerebellar ataxia (HP:0002073) | 5.10471732 |
| 8 | Epileptic encephalopathy (HP:0200134) | 4.98167156 |
| 9 | Absence seizures (HP:0002121) | 4.83016073 |
| 10 | Hyperventilation (HP:0002883) | 4.39222364 |
| 11 | Dialeptic seizures (HP:0011146) | 4.30652972 |
| 12 | Action tremor (HP:0002345) | 4.21833940 |
| 13 | Gaze-evoked nystagmus (HP:0000640) | 4.20243271 |
| 14 | Generalized tonic-clonic seizures (HP:0002069) | 4.15222735 |
| 15 | Broad-based gait (HP:0002136) | 4.05014483 |
| 16 | Dysdiadochokinesis (HP:0002075) | 3.72801160 |
| 17 | Dysmetric saccades (HP:0000641) | 3.39233721 |
| 18 | Scanning speech (HP:0002168) | 3.37040794 |
| 19 | Truncal ataxia (HP:0002078) | 3.33824240 |
| 20 | Abnormality of binocular vision (HP:0011514) | 3.33744310 |
| 21 | Diplopia (HP:0000651) | 3.33744310 |
| 22 | Abnormal eating behavior (HP:0100738) | 3.27406803 |
| 23 | Poor eye contact (HP:0000817) | 3.21699208 |
| 24 | Pheochromocytoma (HP:0002666) | 3.21243690 |
| 25 | Impaired smooth pursuit (HP:0007772) | 3.11776184 |
| 26 | Impaired social interactions (HP:0000735) | 3.10422134 |
| 27 | Abnormal social behavior (HP:0012433) | 3.10422134 |
| 28 | Status epilepticus (HP:0002133) | 3.09903855 |
| 29 | Dysmetria (HP:0001310) | 3.07696554 |
| 30 | Anxiety (HP:0000739) | 3.06895385 |
| 31 | Neuroendocrine neoplasm (HP:0100634) | 2.99409968 |
| 32 | Split foot (HP:0001839) | 2.95237509 |
| 33 | Depression (HP:0000716) | 2.95161235 |
| 34 | Limb dystonia (HP:0002451) | 2.91062064 |
| 35 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.89345331 |
| 36 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.87448518 |
| 37 | Polyphagia (HP:0002591) | 2.85209332 |
| 38 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 2.75040447 |
| 39 | Hemiplegia (HP:0002301) | 2.71602506 |
| 40 | Excessive salivation (HP:0003781) | 2.71371348 |
| 41 | Drooling (HP:0002307) | 2.71371348 |
| 42 | Epileptiform EEG discharges (HP:0011182) | 2.70130475 |
| 43 | Genital tract atresia (HP:0001827) | 2.65804586 |
| 44 | Postural instability (HP:0002172) | 2.64705421 |
| 45 | Vaginal atresia (HP:0000148) | 2.64579835 |
| 46 | Failure to thrive in infancy (HP:0001531) | 2.64575791 |
| 47 | Supranuclear gaze palsy (HP:0000605) | 2.64222272 |
| 48 | Progressive inability to walk (HP:0002505) | 2.64077800 |
| 49 | Genetic anticipation (HP:0003743) | 2.63439724 |
| 50 | Intention tremor (HP:0002080) | 2.62153925 |
| 51 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.60643420 |
| 52 | Aplasia of the phalanges of the hand (HP:0009802) | 2.60643420 |
| 53 | Aplasia involving bones of the extremities (HP:0009825) | 2.60643420 |
| 54 | Sleep apnea (HP:0010535) | 2.58521168 |
| 55 | Abnormality of midbrain morphology (HP:0002418) | 2.57064368 |
| 56 | Molar tooth sign on MRI (HP:0002419) | 2.57064368 |
| 57 | Postural tremor (HP:0002174) | 2.56576541 |
| 58 | EEG with generalized epileptiform discharges (HP:0011198) | 2.55868493 |
| 59 | Hemiparesis (HP:0001269) | 2.54918897 |
| 60 | Abnormality of the lower motor neuron (HP:0002366) | 2.53709000 |
| 61 | Congenital primary aphakia (HP:0007707) | 2.52658821 |
| 62 | Medial flaring of the eyebrow (HP:0010747) | 2.51316679 |
| 63 | Abnormal hair whorl (HP:0010721) | 2.48653222 |
| 64 | Fetal akinesia sequence (HP:0001989) | 2.45634013 |
| 65 | Poor suck (HP:0002033) | 2.45525706 |
| 66 | Hypsarrhythmia (HP:0002521) | 2.44809753 |
| 67 | Bradykinesia (HP:0002067) | 2.43732698 |
| 68 | Amblyopia (HP:0000646) | 2.43355733 |
| 69 | Pancreatic fibrosis (HP:0100732) | 2.41590794 |
| 70 | Abnormality of the corticospinal tract (HP:0002492) | 2.40769615 |
| 71 | Decreased central vision (HP:0007663) | 2.39965483 |
| 72 | Short tibia (HP:0005736) | 2.39319794 |
| 73 | Absent speech (HP:0001344) | 2.38949268 |
| 74 | Hyperglycinemia (HP:0002154) | 2.38017396 |
| 75 | Mutism (HP:0002300) | 2.36331766 |
| 76 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.34925454 |
| 77 | Agitation (HP:0000713) | 2.34706472 |
| 78 | Psychosis (HP:0000709) | 2.34240097 |
| 79 | Ankle clonus (HP:0011448) | 2.32225510 |
| 80 | Cutaneous finger syndactyly (HP:0010554) | 2.31208954 |
| 81 | Horizontal nystagmus (HP:0000666) | 2.30179414 |
| 82 | Nephrogenic diabetes insipidus (HP:0009806) | 2.29835223 |
| 83 | Blue irides (HP:0000635) | 2.29704691 |
| 84 | Resting tremor (HP:0002322) | 2.29045593 |
| 85 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.26284948 |
| 86 | Spastic gait (HP:0002064) | 2.25440629 |
| 87 | Gait ataxia (HP:0002066) | 2.23469680 |
| 88 | Abnormality of saccadic eye movements (HP:0000570) | 2.22018811 |
| 89 | Protruding tongue (HP:0010808) | 2.20105656 |
| 90 | Generalized myoclonic seizures (HP:0002123) | 2.16804319 |
| 91 | Abnormal ciliary motility (HP:0012262) | 2.16791869 |
| 92 | Neuronal loss in central nervous system (HP:0002529) | 2.15810512 |
| 93 | Tetraplegia (HP:0002445) | 2.15304569 |
| 94 | Coronal craniosynostosis (HP:0004440) | 2.15074229 |
| 95 | Abnormality of the parietal bone (HP:0002696) | 2.14325024 |
| 96 | Urinary urgency (HP:0000012) | 2.12572240 |
| 97 | Nephronophthisis (HP:0000090) | 2.12162609 |
| 98 | True hermaphroditism (HP:0010459) | 2.10684571 |
| 99 | Narrow nasal bridge (HP:0000446) | 2.08398789 |
| 100 | Oligomenorrhea (HP:0000876) | 2.08340564 |
| 101 | Impaired vibratory sensation (HP:0002495) | 2.06783049 |
| 102 | Turricephaly (HP:0000262) | 2.06676705 |
| 103 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.05633473 |
| 104 | Focal dystonia (HP:0004373) | 2.04945442 |
| 105 | Torticollis (HP:0000473) | 2.04057681 |
| 106 | Gait imbalance (HP:0002141) | 2.02965094 |
| 107 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.01961836 |
| 108 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.01961836 |
| 109 | Cerebral inclusion bodies (HP:0100314) | 2.01155363 |
| 110 | Pancreatic cysts (HP:0001737) | 1.98565176 |
| 111 | Hypoventilation (HP:0002791) | 1.98258365 |
| 112 | Specific learning disability (HP:0001328) | 1.97496289 |
| 113 | Insidious onset (HP:0003587) | 1.96759203 |
| 114 | Termporal pattern (HP:0011008) | 1.96759203 |
| 115 | Amyotrophic lateral sclerosis (HP:0007354) | 1.96589970 |
| 116 | Inability to walk (HP:0002540) | 1.95586586 |
| 117 | Stereotypic behavior (HP:0000733) | 1.95295108 |
| 118 | Spastic tetraplegia (HP:0002510) | 1.95283222 |
| 119 | Limb ataxia (HP:0002070) | 1.92696461 |
| 120 | Stenosis of the external auditory canal (HP:0000402) | 1.92451072 |
| 121 | Sensorimotor neuropathy (HP:0007141) | 1.91999893 |
| 122 | Esophageal atresia (HP:0002032) | 1.91718322 |
| 123 | Esotropia (HP:0000565) | 1.91697432 |
| 124 | Broad foot (HP:0001769) | 1.91127460 |
| 125 | Delusions (HP:0000746) | 1.90356452 |
| 126 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.89866953 |
| 127 | Postaxial hand polydactyly (HP:0001162) | 1.88445292 |
| 128 | Cutaneous syndactyly (HP:0012725) | 1.88069256 |
| 129 | Incomplete penetrance (HP:0003829) | 1.87721227 |
| 130 | Ventricular fibrillation (HP:0001663) | 1.86961249 |
| 131 | Trigonocephaly (HP:0000243) | 1.86411186 |
| 132 | Rigidity (HP:0002063) | 1.84573021 |
| 133 | Papilledema (HP:0001085) | 1.83677960 |
| 134 | Bronchomalacia (HP:0002780) | 1.81284873 |
| 135 | Craniofacial dystonia (HP:0012179) | 1.80810844 |
| 136 | Neurofibrillary tangles (HP:0002185) | 1.80379539 |
| 137 | Restlessness (HP:0000711) | 1.80033147 |
| 138 | Unsteady gait (HP:0002317) | 1.79378171 |
| 139 | Alacrima (HP:0000522) | 1.77017237 |
| 140 | Abnormality of the middle phalanges of the toes (HP:0010183) | 1.76590457 |
| 141 | Generalized hypotonia (HP:0001290) | 1.76329107 |
| 142 | Occipital encephalocele (HP:0002085) | 1.75838830 |
| 143 | Absent septum pellucidum (HP:0001331) | 1.75386302 |
| 144 | Abnormality of the labia minora (HP:0012880) | 1.75011781 |
| 145 | Humeroradial synostosis (HP:0003041) | 1.73544164 |
| 146 | Synostosis involving the elbow (HP:0003938) | 1.73544164 |
| 147 | Increased corneal curvature (HP:0100692) | 1.73317989 |
| 148 | Keratoconus (HP:0000563) | 1.73317989 |
| 149 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.72472972 |
| 150 | Septo-optic dysplasia (HP:0100842) | 1.70651304 |
| 151 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.68401005 |
| 152 | Hypothermia (HP:0002045) | 1.66916164 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 4.07593106 |
| 2 | CASK | 3.67988792 |
| 3 | MAP3K4 | 3.65894485 |
| 4 | MAP2K7 | 3.25483186 |
| 5 | MAP3K9 | 3.24982221 |
| 6 | MAP3K12 | 3.20640792 |
| 7 | FGFR2 | 2.90571012 |
| 8 | EPHA4 | 2.89171958 |
| 9 | MAP2K4 | 2.56806748 |
| 10 | CDK19 | 2.53233616 |
| 11 | MINK1 | 2.41630932 |
| 12 | MARK1 | 2.29638598 |
| 13 | DAPK2 | 2.16488107 |
| 14 | CAMKK2 | 2.10059552 |
| 15 | NTRK2 | 2.09851999 |
| 16 | RIPK4 | 1.88289102 |
| 17 | PNCK | 1.70607289 |
| 18 | OXSR1 | 1.67974215 |
| 19 | PAK6 | 1.63250744 |
| 20 | GRK5 | 1.59904944 |
| 21 | PLK2 | 1.59861461 |
| 22 | CAMKK1 | 1.55326936 |
| 23 | DAPK1 | 1.53071026 |
| 24 | ARAF | 1.43611155 |
| 25 | PRPF4B | 1.43201338 |
| 26 | PRKCG | 1.42715123 |
| 27 | DYRK2 | 1.38263912 |
| 28 | CDK5 | 1.32014472 |
| 29 | KSR2 | 1.31115910 |
| 30 | MAPK13 | 1.26467839 |
| 31 | SIK2 | 1.25584018 |
| 32 | MAP3K11 | 1.25511432 |
| 33 | AKT3 | 1.24106788 |
| 34 | PKN1 | 1.22680846 |
| 35 | TNIK | 1.21278120 |
| 36 | NTRK1 | 1.19062340 |
| 37 | KSR1 | 1.16593106 |
| 38 | SGK223 | 1.16023695 |
| 39 | SGK494 | 1.16023695 |
| 40 | STK38 | 1.16016449 |
| 41 | CAMK2A | 1.15637284 |
| 42 | SGK2 | 1.14734638 |
| 43 | MAP3K13 | 1.12837914 |
| 44 | BCKDK | 1.11961238 |
| 45 | CSNK1G3 | 1.08200057 |
| 46 | WNK1 | 1.05384652 |
| 47 | CAMK2B | 1.03992611 |
| 48 | UHMK1 | 0.98679749 |
| 49 | TRIM28 | 0.95650383 |
| 50 | CSNK1G1 | 0.95260056 |
| 51 | FES | 0.92629725 |
| 52 | MAP4K2 | 0.90837038 |
| 53 | CDK18 | 0.88164124 |
| 54 | CDK15 | 0.86239708 |
| 55 | SGK3 | 0.86216198 |
| 56 | CAMK2G | 0.83815634 |
| 57 | BMPR2 | 0.83663805 |
| 58 | PINK1 | 0.82297278 |
| 59 | CSNK1A1L | 0.81061912 |
| 60 | CDK14 | 0.80358369 |
| 61 | CAMK1 | 0.80295302 |
| 62 | TSSK6 | 0.80200176 |
| 63 | PRKCH | 0.79771004 |
| 64 | STK11 | 0.79509198 |
| 65 | EPHA3 | 0.78838944 |
| 66 | EPHB2 | 0.77029419 |
| 67 | NME1 | 0.75770037 |
| 68 | WNK3 | 0.75268198 |
| 69 | CDK11A | 0.73271511 |
| 70 | CAMK2D | 0.71955557 |
| 71 | TYRO3 | 0.71626616 |
| 72 | PLK3 | 0.69941243 |
| 73 | DYRK1A | 0.68638513 |
| 74 | PDK4 | 0.67849208 |
| 75 | PDK3 | 0.67849208 |
| 76 | PHKG1 | 0.67559114 |
| 77 | PHKG2 | 0.67559114 |
| 78 | CSNK1G2 | 0.67157704 |
| 79 | PRKCE | 0.66468787 |
| 80 | TLK1 | 0.65388231 |
| 81 | MAPK15 | 0.63947587 |
| 82 | SGK1 | 0.63904477 |
| 83 | ADRBK2 | 0.62842816 |
| 84 | SIK3 | 0.61664382 |
| 85 | TNK2 | 0.61603548 |
| 86 | GRK7 | 0.61014682 |
| 87 | PTK2B | 0.60504195 |
| 88 | BMPR1B | 0.60481138 |
| 89 | MAP3K5 | 0.58885993 |
| 90 | RET | 0.57751396 |
| 91 | RIPK1 | 0.57505820 |
| 92 | MAPKAPK5 | 0.56463082 |
| 93 | ZAK | 0.55711034 |
| 94 | PDK1 | 0.55321134 |
| 95 | CAMK4 | 0.54396104 |
| 96 | BRAF | 0.54058072 |
| 97 | MAP3K2 | 0.53814776 |
| 98 | MUSK | 0.53791540 |
| 99 | PRKD3 | 0.51341527 |
| 100 | PRKACB | 0.50736601 |
| 101 | INSRR | 0.50542027 |
| 102 | PDPK1 | 0.50427089 |
| 103 | ERBB3 | 0.49678653 |
| 104 | PAK3 | 0.49281354 |
| 105 | RAF1 | 0.49198650 |
| 106 | ROCK2 | 0.47581041 |
| 107 | RPS6KA3 | 0.46740875 |
| 108 | GRK1 | 0.46641447 |
| 109 | SRPK1 | 0.45703389 |
| 110 | LATS2 | 0.45558595 |
| 111 | STK38L | 0.45553267 |
| 112 | ADRBK1 | 0.45394775 |
| 113 | DYRK3 | 0.44594452 |
| 114 | FER | 0.42925006 |
| 115 | MAP3K6 | 0.42872230 |
| 116 | CDK3 | 0.42219578 |
| 117 | FYN | 0.42107760 |
| 118 | PRKACA | 0.41007657 |
| 119 | CAMK1G | 0.40571267 |
| 120 | CCNB1 | 0.40122886 |
| 121 | CSNK1E | 0.38930914 |
| 122 | DYRK1B | 0.38749259 |
| 123 | SCYL2 | 0.38258887 |
| 124 | PRKG1 | 0.37444852 |
| 125 | BCR | 0.37151726 |
| 126 | ALK | 0.36649282 |
| 127 | MAP3K1 | 0.35797053 |
| 128 | PRKCZ | 0.35245552 |
| 129 | MARK2 | 0.34399557 |
| 130 | PIK3CA | 0.34217131 |
| 131 | MKNK2 | 0.33801758 |
| 132 | PRKCA | 0.32362681 |
| 133 | CSNK1A1 | 0.30262891 |
| 134 | PRKCB | 0.28211309 |
| 135 | MAPK10 | 0.26343859 |
| 136 | CSNK1D | 0.26204532 |
| 137 | DDR2 | 0.25874957 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.57875393 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.79957922 |
| 3 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.94764380 |
| 4 | GABAergic synapse_Homo sapiens_hsa04727 | 2.87427102 |
| 5 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.60418290 |
| 6 | Morphine addiction_Homo sapiens_hsa05032 | 2.58739896 |
| 7 | Long-term potentiation_Homo sapiens_hsa04720 | 2.57172986 |
| 8 | Circadian entrainment_Homo sapiens_hsa04713 | 2.51412098 |
| 9 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.43967467 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.39210254 |
| 11 | Olfactory transduction_Homo sapiens_hsa04740 | 2.26204771 |
| 12 | Taste transduction_Homo sapiens_hsa04742 | 2.16764502 |
| 13 | Long-term depression_Homo sapiens_hsa04730 | 2.06841306 |
| 14 | Salivary secretion_Homo sapiens_hsa04970 | 2.05724257 |
| 15 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.02744038 |
| 16 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.94118076 |
| 17 | Insulin secretion_Homo sapiens_hsa04911 | 1.78807607 |
| 18 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.71952634 |
| 19 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.67197567 |
| 20 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.65910761 |
| 21 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.65788913 |
| 22 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.63100498 |
| 23 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.60476645 |
| 24 | Cocaine addiction_Homo sapiens_hsa05030 | 1.58609225 |
| 25 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.52419925 |
| 26 | Renin secretion_Homo sapiens_hsa04924 | 1.52117208 |
| 27 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.46304059 |
| 28 | Protein export_Homo sapiens_hsa03060 | 1.45248886 |
| 29 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.42051557 |
| 30 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.39141183 |
| 31 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.37861961 |
| 32 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.37570559 |
| 33 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.26142633 |
| 34 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.25984223 |
| 35 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.24764106 |
| 36 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.24188648 |
| 37 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.21931182 |
| 38 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.21019434 |
| 39 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.17700461 |
| 40 | Gap junction_Homo sapiens_hsa04540 | 1.17567372 |
| 41 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.15460041 |
| 42 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.11876235 |
| 43 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.11018729 |
| 44 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.09964011 |
| 45 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.06164998 |
| 46 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.03259052 |
| 47 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.99757732 |
| 48 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.98580326 |
| 49 | Alzheimers disease_Homo sapiens_hsa05010 | 0.93133927 |
| 50 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.90532160 |
| 51 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.88588934 |
| 52 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.87389186 |
| 53 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.87334191 |
| 54 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.86769168 |
| 55 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.82282486 |
| 56 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.80675778 |
| 57 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.80428711 |
| 58 | Parkinsons disease_Homo sapiens_hsa05012 | 0.79639735 |
| 59 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.79086510 |
| 60 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.77533422 |
| 61 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.76557588 |
| 62 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.73447247 |
| 63 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.71878397 |
| 64 | Melanogenesis_Homo sapiens_hsa04916 | 0.70695477 |
| 65 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.69799787 |
| 66 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.69765195 |
| 67 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.67317118 |
| 68 | Glioma_Homo sapiens_hsa05214 | 0.65725479 |
| 69 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.64676341 |
| 70 | Axon guidance_Homo sapiens_hsa04360 | 0.64145482 |
| 71 | Bile secretion_Homo sapiens_hsa04976 | 0.64029452 |
| 72 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.63324189 |
| 73 | Phototransduction_Homo sapiens_hsa04744 | 0.61833862 |
| 74 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.60552857 |
| 75 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.59528951 |
| 76 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.59206010 |
| 77 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.56521097 |
| 78 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.55830152 |
| 79 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.52373263 |
| 80 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.51553704 |
| 81 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.51375944 |
| 82 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.51228469 |
| 83 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.50759173 |
| 84 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.50151277 |
| 85 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.49584798 |
| 86 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.49583913 |
| 87 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.48507893 |
| 88 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.48346738 |
| 89 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.47852590 |
| 90 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.47039030 |
| 91 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.46361781 |
| 92 | Huntingtons disease_Homo sapiens_hsa05016 | 0.44991549 |
| 93 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.42857335 |
| 94 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.42399916 |
| 95 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.42119805 |
| 96 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.40543232 |
| 97 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.38359743 |
| 98 | Circadian rhythm_Homo sapiens_hsa04710 | 0.37130441 |
| 99 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.37115496 |
| 100 | Alcoholism_Homo sapiens_hsa05034 | 0.36867364 |
| 101 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.36496592 |
| 102 | Phagosome_Homo sapiens_hsa04145 | 0.35609539 |
| 103 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.34999682 |
| 104 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.34113710 |
| 105 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.33766004 |
| 106 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.33326521 |
| 107 | Histidine metabolism_Homo sapiens_hsa00340 | 0.31187986 |
| 108 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.30441561 |
| 109 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.30105536 |
| 110 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.29758714 |
| 111 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.29263381 |
| 112 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.28109320 |
| 113 | Mineral absorption_Homo sapiens_hsa04978 | 0.28046188 |
| 114 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.27390962 |
| 115 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.25967256 |
| 116 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.25143758 |
| 117 | Prion diseases_Homo sapiens_hsa05020 | 0.22586771 |
| 118 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.22334964 |
| 119 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.22149121 |
| 120 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.21929635 |
| 121 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.21744366 |
| 122 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.21023599 |
| 123 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.20921853 |
| 124 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.19437205 |
| 125 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.19342139 |
| 126 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.18984449 |
| 127 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.17816088 |

