OLFM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cAMP-mediated signaling (GO:0043950)9.32521221
2angiotensin maturation (GO:0002003)8.39094841
3exploration behavior (GO:0035640)8.34070859
4neuronal stem cell maintenance (GO:0097150)8.29066731
5proline metabolic process (GO:0006560)7.64761518
6defense response to fungus (GO:0050832)7.51762139
7regulation of respiratory burst (GO:0060263)7.50171087
8regulation of hydrogen peroxide metabolic process (GO:0010310)6.74997607
9endocrine pancreas development (GO:0031018)6.71992735
10regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.65095693
11acylglycerol homeostasis (GO:0055090)6.46777187
12triglyceride homeostasis (GO:0070328)6.46777187
13dentate gyrus development (GO:0021542)6.46465638
14regulation of guanylate cyclase activity (GO:0031282)6.26920859
15killing of cells of other organism (GO:0031640)6.07629246
16disruption of cells of other organism (GO:0044364)6.07629246
17membrane repolarization during cardiac muscle cell action potential (GO:0086013)6.06328638
18calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)6.05436801
19positive regulation of respiratory burst (GO:0060267)5.72021455
20glutamine family amino acid biosynthetic process (GO:0009084)5.58105530
21positive regulation of digestive system process (GO:0060456)5.57436016
22digestive system process (GO:0022600)5.44311353
23membrane repolarization during action potential (GO:0086011)5.32472010
24intestinal absorption (GO:0050892)5.18551226
25negative regulation of glial cell proliferation (GO:0060253)5.11255004
26maintenance of gastrointestinal epithelium (GO:0030277)5.11149181
27potassium ion export (GO:0071435)5.04961759
28sequestering of metal ion (GO:0051238)5.04798300
29positive regulation of glucose transport (GO:0010828)5.01793569
30intestinal epithelial cell development (GO:0060576)4.99083254
31leukocyte migration involved in inflammatory response (GO:0002523)4.86624183
32regulation of cAMP-mediated signaling (GO:0043949)4.85498574
33positive regulation of guanylate cyclase activity (GO:0031284)4.85448498
34positive regulation of pseudopodium assembly (GO:0031274)4.77813650
35hepatocyte apoptotic process (GO:0097284)4.76472139
36cardiovascular system development (GO:0072358)4.69983812
37negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.64995304
38response to fungus (GO:0009620)4.64724834
39complement activation, classical pathway (GO:0006958)4.61366348
40pentose-phosphate shunt (GO:0006098)4.60961169
41cell differentiation involved in embryonic placenta development (GO:0060706)4.58862254
42antimicrobial humoral response (GO:0019730)4.50926972
43antibacterial humoral response (GO:0019731)4.47473862
44regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.47215713
45endocrine process (GO:0050886)4.47215713
46regulation of systemic arterial blood pressure by hormone (GO:0001990)4.47215713
47glomerular filtration (GO:0003094)4.43174493
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.41176414
49lipoprotein transport (GO:0042953)4.40111978
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.34099067
51atrial cardiac muscle cell action potential (GO:0086014)4.34075866
52regulation of pseudopodium assembly (GO:0031272)4.28625654
53digestion (GO:0007586)4.27900474
54leukocyte aggregation (GO:0070486)4.25750222
55epoxygenase P450 pathway (GO:0019373)4.24590064
56antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.20873354
57NADPH regeneration (GO:0006740)4.17631472
58regulation of systemic arterial blood pressure (GO:0003073)4.08012499
59citrulline biosynthetic process (GO:0019240)4.05622831
60hormone catabolic process (GO:0042447)4.04420404
61renal filtration (GO:0097205)4.01868000
62cellular glucuronidation (GO:0052695)4.00807932
63cellular response to epinephrine stimulus (GO:0071872)4.00671487
64antigen processing and presentation of endogenous antigen (GO:0019883)3.99479690
65fat-soluble vitamin biosynthetic process (GO:0042362)3.99207915
66peptide catabolic process (GO:0043171)3.98006859
67positive regulation of glycoprotein biosynthetic process (GO:0010560)3.97510186
68uronic acid metabolic process (GO:0006063)3.96610773
69glucuronate metabolic process (GO:0019585)3.96610773
70long-term synaptic potentiation (GO:0060291)3.94538566
71transcytosis (GO:0045056)3.93997271
72UDP-N-acetylglucosamine metabolic process (GO:0006047)3.92886358
73ATP synthesis coupled proton transport (GO:0015986)3.83734366
74energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83734366
75fructose metabolic process (GO:0006000)3.82333778
76urea cycle (GO:0000050)3.81125859
77urea metabolic process (GO:0019627)3.81125859
78regulation of cGMP biosynthetic process (GO:0030826)3.80311692
79epithelial structure maintenance (GO:0010669)3.78271171
80adhesion of symbiont to host cell (GO:0044650)3.77923111
81virion attachment to host cell (GO:0019062)3.77923111
82receptor guanylyl cyclase signaling pathway (GO:0007168)3.75935355
83intestinal cholesterol absorption (GO:0030299)3.74772929
84ventricular cardiac muscle cell action potential (GO:0086005)3.73883753
85peptide hormone processing (GO:0016486)3.69536368
86diacylglycerol metabolic process (GO:0046339)3.67883625
87complement activation (GO:0006956)3.67101199
88NADH metabolic process (GO:0006734)3.66976209
89positive regulation of glycoprotein metabolic process (GO:1903020)3.62042022
90cobalamin metabolic process (GO:0009235)3.58102336
91positive regulation of chemokine secretion (GO:0090197)3.56686702
92arginine metabolic process (GO:0006525)3.54696494
93positive regulation of insulin secretion (GO:0032024)3.54419028
94glycolipid catabolic process (GO:0019377)3.51212254
95cellular extravasation (GO:0045123)3.48497599
96killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.47774474
97disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.47774474
98membrane repolarization (GO:0086009)3.46372088
99regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.43469781
100L-serine transport (GO:0015825)3.42954749
101negative regulation of epidermal cell differentiation (GO:0045605)3.41500227
102phosphatidylserine acyl-chain remodeling (GO:0036150)3.41131857
103response to axon injury (GO:0048678)3.39589165
104nitrogen cycle metabolic process (GO:0071941)3.36318933
105glycosphingolipid catabolic process (GO:0046479)3.34906891
106regulation of dendritic cell antigen processing and presentation (GO:0002604)3.32315650
107bile acid and bile salt transport (GO:0015721)3.30942487
108regulation of vitamin metabolic process (GO:0030656)3.30688324
109renal system process involved in regulation of blood volume (GO:0001977)3.30259830
110negative regulation of keratinocyte proliferation (GO:0010839)3.30182588
111regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.29203668
112phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.27256555
113regulation of chemokine secretion (GO:0090196)3.26454449
114regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.26250951
115primary alcohol metabolic process (GO:0034308)3.26101176
116GDP-mannose metabolic process (GO:0019673)3.25259919
117very-low-density lipoprotein particle assembly (GO:0034379)3.23446612
118drug metabolic process (GO:0017144)3.15697420
119adhesion of symbiont to host (GO:0044406)3.13449361
120response to epinephrine (GO:0071871)3.12092251
121regulation of bile acid biosynthetic process (GO:0070857)3.11945967
122leukotriene biosynthetic process (GO:0019370)3.11261076
123regulation of cGMP metabolic process (GO:0030823)3.10519398
124eosinophil chemotaxis (GO:0048245)3.10478946
125galactose catabolic process (GO:0019388)3.09859721
126oligosaccharide biosynthetic process (GO:0009312)3.08485695
127O-glycan processing (GO:0016266)3.08250337
128diol metabolic process (GO:0034311)3.06162137
129positive regulation of Cdc42 GTPase activity (GO:0043089)3.06039569
130glucose catabolic process (GO:0006007)3.05979291
131flavonoid metabolic process (GO:0009812)3.04104934
132* regulation of cellular extravasation (GO:0002691)3.01712008
133serine transport (GO:0032329)3.01430483
134vitamin A metabolic process (GO:0006776)3.01155780
135phosphatidylinositol acyl-chain remodeling (GO:0036149)3.00660937
136arginine catabolic process (GO:0006527)2.99778545
137regulation of heart rate by cardiac conduction (GO:0086091)2.99524857
138eosinophil migration (GO:0072677)2.96464535
139cell killing (GO:0001906)2.94779776
140auditory receptor cell differentiation (GO:0042491)2.94430298
141cellular response to vitamin D (GO:0071305)2.93862542
142regulation of glial cell proliferation (GO:0060251)2.92701227
143regulation of triglyceride catabolic process (GO:0010896)2.89351146
144ethanol oxidation (GO:0006069)2.88984008
145bundle of His cell to Purkinje myocyte communication (GO:0086069)2.87509801
146leukotriene metabolic process (GO:0006691)2.86420148
147humoral immune response (GO:0006959)2.86243866
148negative regulation of interleukin-1 beta production (GO:0032691)2.85328247
149detection of bacterium (GO:0016045)2.85165603
150ceramide catabolic process (GO:0046514)2.84429410
151positive regulation of potassium ion transmembrane transport (GO:1901381)2.84042116
152phospholipid scrambling (GO:0017121)2.83368158
153regulation of interleukin-8 secretion (GO:2000482)2.82251851
154regulation of transforming growth factor beta1 production (GO:0032908)2.81569990
155phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.80937251
156alkaloid metabolic process (GO:0009820)2.80189604
157positive regulation of cGMP biosynthetic process (GO:0030828)2.80155851
158sexual reproduction (GO:0019953)2.79786915
159nucleoside diphosphate biosynthetic process (GO:0009133)2.78387699
160plasma lipoprotein particle assembly (GO:0034377)2.77049419
161actin filament depolymerization (GO:0030042)2.76614277
162regulation of cholesterol homeostasis (GO:2000188)2.76052022
163midgut development (GO:0007494)2.75214877
164protein activation cascade (GO:0072376)2.73423258
165innate immune response in mucosa (GO:0002227)2.73403301
166secretion by tissue (GO:0032941)2.72985037
167chronic inflammatory response (GO:0002544)2.72819277
168positive regulation of peptide hormone secretion (GO:0090277)2.72236505
169positive regulation of peptide secretion (GO:0002793)2.61749236
170positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.59115367
171hexose catabolic process (GO:0019320)2.58800449
172oxidative phosphorylation (GO:0006119)2.57674256
173superoxide metabolic process (GO:0006801)2.56859172
174lipid homeostasis (GO:0055088)2.55282550
175negative regulation of interleukin-1 production (GO:0032692)2.54770824
176decidualization (GO:0046697)2.54394414
177primary alcohol catabolic process (GO:0034310)11.2581943
178proline biosynthetic process (GO:0006561)10.7606809
179ethanol metabolic process (GO:0006067)10.0486666

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.02045279
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.90582438
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.41462024
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse4.06315127
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.40040442
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.29311396
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.92883488
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.92624815
9E2F7_22180533_ChIP-Seq_HELA_Human2.88385979
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.88350548
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.81686488
12GATA4_25053715_ChIP-Seq_YYC3_Human2.81284338
13GATA6_25053715_ChIP-Seq_YYC3_Human2.72723774
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.69506587
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65501302
16SOX2_20726797_ChIP-Seq_SW620_Human2.20814801
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.18067558
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.15999616
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.12553714
20AR_21909140_ChIP-Seq_LNCAP_Human2.10339709
21ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.08966722
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.05326124
23EZH2_22144423_ChIP-Seq_EOC_Human2.01863789
24FOXM1_23109430_ChIP-Seq_U2OS_Human1.96542136
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.94947580
26BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.87334952
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77176249
28VDR_21846776_ChIP-Seq_THP-1_Human1.73928625
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.73429529
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.71197870
31LXR_22292898_ChIP-Seq_THP-1_Human1.66669521
32SRY_22984422_ChIP-ChIP_TESTIS_Rat1.65282737
33ATF3_27146783_Chip-Seq_COLON_Human1.63640057
34GATA1_22025678_ChIP-Seq_K562_Human1.59346767
35PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56686173
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56023741
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55398585
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53524862
39RACK7_27058665_Chip-Seq_MCF-7_Human1.51996968
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48437398
41TCF4_18268006_ChIP-ChIP_LS174T_Human1.47805471
42* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46385026
43* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.44302555
44SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.43582193
45BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.42178136
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40791092
47* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39769798
48STAT1_20625510_ChIP-Seq_HELA_Human1.38550766
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38250471
50AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37950400
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37766645
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.36369288
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35407992
54PHF8_20622854_ChIP-Seq_HELA_Human1.35092644
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.32174817
56* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27446631
57SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27442064
58CLOCK_20551151_ChIP-Seq_293T_Human1.26822498
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24834480
60VDR_24763502_ChIP-Seq_THP-1_Human1.23608036
61ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22242516
62EGR1_19032775_ChIP-ChIP_M12_Human1.20645324
63IRF8_27001747_Chip-Seq_BMDM_Mouse1.19150214
64NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19025902
65P68_20966046_ChIP-Seq_HELA_Human1.18565927
66BCL6_27268052_Chip-Seq_Bcells_Human1.18349682
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.18117873
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17172251
69KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16230630
70CTCF_27219007_Chip-Seq_Bcells_Human1.15737318
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.15384134
72FOXA1_25552417_ChIP-Seq_VCAP_Human1.15358591
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14973873
74NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14555322
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13710479
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13004865
77P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12117013
78FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11472833
79OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10728084
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.10095996
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09601316
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09090323
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09077943
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.08584627
85FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07106523
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06792263
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06477029
88FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05669174
89BCOR_27268052_Chip-Seq_Bcells_Human1.04501471
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04396597
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03354918
92UTX_26944678_Chip-Seq_JUKART_Human1.01432193
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00640025
94CDX2_22108803_ChIP-Seq_LS180_Human1.00524172
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99164786
96HNF4A_19822575_ChIP-Seq_HepG2_Human0.98564632
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98001787
98* NANOG_20526341_ChIP-Seq_ESCs_Human0.97945304
99FOXA2_19822575_ChIP-Seq_HepG2_Human0.97000062
100CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96692655
101SMAD_19615063_ChIP-ChIP_OVARY_Human0.96055535
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95796993
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95796993
104CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95459757
105KLF5_25053715_ChIP-Seq_YYC3_Human0.95182249
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.95144449
107SA1_27219007_Chip-Seq_ERYTHROID_Human0.95018479
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94859264
109GATA2_19941826_ChIP-Seq_K562_Human0.94680664
110KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94641957
111HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94041096
112GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93735972
113VDR_24787735_ChIP-Seq_THP-1_Human0.92720189
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90173787
115SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89916752
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89229054
117E2F1_20622854_ChIP-Seq_HELA_Human0.89190391
118MYC_19079543_ChIP-ChIP_MESCs_Mouse0.88329416
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88281518
120SA1_27219007_Chip-Seq_Bcells_Human0.88279839
121JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88271182
122CREB1_26743006_Chip-Seq_LNCaP_Human0.88081458
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87966365
124* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87949269
125MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87923937
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87199571
127ELK3_25401928_ChIP-Seq_HUVEC_Human0.86872271
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85772376
129CEBPB_22108803_ChIP-Seq_LS180_Human0.85684681
130GATA1_19941826_ChIP-Seq_K562_Human0.85325380
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84572600
132GATA3_24758297_ChIP-Seq_MCF-7_Human0.84008624
133STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83843279
134ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83723643
135RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83691650
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83562475
137DROSHA_22980978_ChIP-Seq_HELA_Human0.82757155
138GATA2_21666600_ChIP-Seq_HMVEC_Human0.80759158
139STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79616400
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78814216
141TET1_21451524_ChIP-Seq_MESCs_Mouse0.78437401
142PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78164630
143SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77949139
144RXR_22108803_ChIP-Seq_LS180_Human0.77550300
145FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76311200

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH6.04931254
2MP0003123_paternal_imprinting4.98825989
3MP0005360_urolithiasis3.87656136
4MP0004264_abnormal_extraembryonic_tissu3.87147085
5MP0010234_abnormal_vibrissa_follicle3.85442779
6MP0003300_gastrointestinal_ulcer3.84137135
7MP0000462_abnormal_digestive_system3.69665443
8MP0000490_abnormal_crypts_of3.63928500
9MP0003787_abnormal_imprinting3.56158458
10MP0010155_abnormal_intestine_physiology3.00514406
11MP0003866_abnormal_defecation2.99357059
12MP0000537_abnormal_urethra_morphology2.98913394
13MP0001666_abnormal_nutrient_absorption2.93408316
14MP0002139_abnormal_hepatobiliary_system2.83812449
15MP0004147_increased_porphyrin_level2.76533642
16MP0003806_abnormal_nucleotide_metabolis2.60900909
17MP0010352_gastrointestinal_tract_polyps2.59828785
18* MP0001663_abnormal_digestive_system2.37197553
19MP0001485_abnormal_pinna_reflex2.32524344
20MP0002876_abnormal_thyroid_physiology2.13733028
21MP0003693_abnormal_embryo_hatching2.04118819
22MP0003868_abnormal_feces_composition1.99473261
23MP0005085_abnormal_gallbladder_physiolo1.95536189
24MP0004858_abnormal_nervous_system1.94450797
25* MP0005381_digestive/alimentary_phenotyp1.94165985
26MP0005409_darkened_coat_color1.88962962
27MP0000477_abnormal_intestine_morphology1.87845685
28MP0003303_peritoneal_inflammation1.84736617
29MP0008872_abnormal_physiological_respon1.75570679
30MP0001664_abnormal_digestion1.63376261
31MP0003183_abnormal_peptide_metabolism1.59254507
32MP0004043_abnormal_pH_regulation1.56449888
33MP0002254_reproductive_system_inflammat1.54680557
34MP0003436_decreased_susceptibility_to1.42421640
35MP0002909_abnormal_adrenal_gland1.42390583
36MP0009785_altered_susceptibility_to1.39734342
37MP0009643_abnormal_urine_homeostasis1.38185547
38MP0005387_immune_system_phenotype1.35999098
39MP0001790_abnormal_immune_system1.35999098
40MP0003724_increased_susceptibility_to1.28988267
41MP0009379_abnormal_foot_pigmentation1.27774398
42MP0009840_abnormal_foam_cell1.25644418
43MP0001835_abnormal_antigen_presentation1.24775841
44MP0001348_abnormal_lacrimal_gland1.24506102
45MP0003828_pulmonary_edema1.23867984
46MP0005365_abnormal_bile_salt1.23363751
47MP0004019_abnormal_vitamin_homeostasis1.21527198
48* MP0001873_stomach_inflammation1.21098921
49MP0003191_abnormal_cellular_cholesterol1.20957695
50MP0003315_abnormal_perineum_morphology1.20155673
51MP0000470_abnormal_stomach_morphology1.18036273
52MP0003656_abnormal_erythrocyte_physiolo1.17069955
53MP0002136_abnormal_kidney_physiology1.15201147
54MP0002693_abnormal_pancreas_physiology1.13163797
55MP0003329_amyloid_beta_deposits1.06667152
56MP0010329_abnormal_lipoprotein_level1.06188355
57MP0005166_decreased_susceptibility_to1.04517927
58MP0002138_abnormal_hepatobiliary_system1.03070153
59MP0000613_abnormal_salivary_gland1.01733643
60MP0002118_abnormal_lipid_homeostasis1.01473072
61MP0003705_abnormal_hypodermis_morpholog1.00057672
62MP0005332_abnormal_amino_acid0.99383357
63MP0004957_abnormal_blastocyst_morpholog0.98844341
64MP0004782_abnormal_surfactant_physiolog0.98063189
65MP0002089_abnormal_postnatal_growth/wei0.97506509
66MP0008875_abnormal_xenobiotic_pharmacok0.96728863
67* MP0005025_abnormal_response_to0.94850548
68MP0002277_abnormal_respiratory_mucosa0.94777654
69MP0003252_abnormal_bile_duct0.93745277
70MP0001501_abnormal_sleep_pattern0.93257640
71MP0004947_skin_inflammation0.93250708
72MP0002098_abnormal_vibrissa_morphology0.92903572
73MP0003121_genomic_imprinting0.92711433
74MP0003453_abnormal_keratinocyte_physiol0.92191726
75MP0001764_abnormal_homeostasis0.91793923
76MP0001188_hyperpigmentation0.91403384
77MP0006082_CNS_inflammation0.91117496
78MP0000604_amyloidosis0.89472905
79MP0001851_eye_inflammation0.88525660
80MP0005670_abnormal_white_adipose0.87477714
81MP0002006_tumorigenesis0.87292147
82MP0002796_impaired_skin_barrier0.86909570
83MP0001849_ear_inflammation0.86632945
84MP0001800_abnormal_humoral_immune0.86577993
85* MP0001845_abnormal_inflammatory_respons0.85783693
86MP0004883_abnormal_blood_vessel0.85653101
87MP0002419_abnormal_innate_immunity0.84361761
88MP0005671_abnormal_response_to0.82998445
89MP0006054_spinal_hemorrhage0.82584706
90MP0005220_abnormal_exocrine_pancreas0.81384544
91MP0002166_altered_tumor_susceptibility0.80884075
92MP0009764_decreased_sensitivity_to0.79994857
93* MP0008469_abnormal_protein_level0.79521436
94MP0001533_abnormal_skeleton_physiology0.78710656
95MP0010386_abnormal_urinary_bladder0.78632411
96MP0005000_abnormal_immune_tolerance0.77878712
97MP0002971_abnormal_brown_adipose0.75853168
98MP0005451_abnormal_body_composition0.75361948
99MP0000230_abnormal_systemic_arterial0.75303258
100MP0002896_abnormal_bone_mineralization0.74923375
101MP0009333_abnormal_splenocyte_physiolog0.73109353
102MP0000249_abnormal_blood_vessel0.71329196
103MP0000678_abnormal_parathyroid_gland0.69790738
104MP0005165_increased_susceptibility_to0.69438237
105MP0009115_abnormal_fat_cell0.69325838
106MP0003045_fibrosis0.69092882
107MP0005319_abnormal_enzyme/_coenzyme0.68831351
108MP0005535_abnormal_body_temperature0.68135505
109MP0000681_abnormal_thyroid_gland0.67986526
110MP0000609_abnormal_liver_physiology0.67478000
111MP0006036_abnormal_mitochondrial_physio0.67157035
112MP0001881_abnormal_mammary_gland0.66747452
113MP0001765_abnormal_ion_homeostasis0.66688815
114MP0003879_abnormal_hair_cell0.66449819
115MP0002452_abnormal_antigen_presenting0.66330974
116MP0002998_abnormal_bone_remodeling0.65825540
117MP0002148_abnormal_hypersensitivity_rea0.65737923
118MP0005448_abnormal_energy_balance0.63001589
119MP0001944_abnormal_pancreas_morphology0.62687966
120MP0005310_abnormal_salivary_gland0.62581075
121MP0002405_respiratory_system_inflammati0.59536583
122MP0003075_altered_response_to0.58044815
123MP0005187_abnormal_penis_morphology0.57625147
124MP0001216_abnormal_epidermal_layer0.57115068
125MP0004484_altered_response_of0.56315031
126MP0000685_abnormal_immune_system0.56088801
127MP0003137_abnormal_impulse_conducting0.55822353
128MP0009765_abnormal_xenobiotic_induced0.55696318
129MP0002822_catalepsy0.55466996
130MP0005584_abnormal_enzyme/coenzyme_acti0.55111819
131MP0005636_abnormal_mineral_homeostasis0.53431980
132MP0003566_abnormal_cell_adhesion0.52425376
133MP0000465_gastrointestinal_hemorrhage0.51987831
134MP0000538_abnormal_urinary_bladder0.51468607
135MP0000858_altered_metastatic_potential0.50883834
136MP0001756_abnormal_urination0.49696350
137MP0005464_abnormal_platelet_physiology0.48815232

Predicted human phenotypes

RankGene SetZ-score
1Hypercortisolism (HP:0001578)9.90616597
2Ventricular fibrillation (HP:0001663)8.77813149
3Congenital sensorineural hearing impairment (HP:0008527)7.51990553
4Posterior subcapsular cataract (HP:0007787)7.44940295
5Ileus (HP:0002595)6.22829426
6Systemic lupus erythematosus (HP:0002725)5.56720816
7Late onset (HP:0003584)5.50152511
8Chorioretinal atrophy (HP:0000533)5.48058075
9Hydroxyprolinuria (HP:0003080)5.34072525
10Abnormality of proline metabolism (HP:0010907)5.34072525
11Fat malabsorption (HP:0002630)5.31628416
12Ketoacidosis (HP:0001993)4.89854487
13Chronic diarrhea (HP:0002028)4.80592428
14Adrenal overactivity (HP:0002717)4.75860231
15Subcapsular cataract (HP:0000523)4.35750966
16Steatorrhea (HP:0002570)4.23402054
17Abnormality of the pancreatic islet cells (HP:0006476)3.96653175
18Abnormality of endocrine pancreas physiology (HP:0012093)3.96653175
19Decreased circulating renin level (HP:0003351)3.93599755
20Hyperactive renin-angiotensin system (HP:0000841)3.87540709
21Abdominal distention (HP:0003270)3.52535955
22Metabolic alkalosis (HP:0200114)3.51308673
23Glomerulonephritis (HP:0000099)3.39784216
24Syncope (HP:0001279)3.38027047
25Alkalosis (HP:0001948)3.28504781
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.25532082
27Eczematoid dermatitis (HP:0000976)3.22122784
28Pustule (HP:0200039)3.20585888
29Ketosis (HP:0001946)3.20569388
30Abnormality of renin-angiotensin system (HP:0000847)3.18034314
31Micronodular cirrhosis (HP:0001413)3.14102838
32Abnormality of complement system (HP:0005339)3.08861578
33Rectal prolapse (HP:0002035)3.03631545
34Right ventricular cardiomyopathy (HP:0011663)3.01626788
35Complement deficiency (HP:0004431)3.00735790
36Villous atrophy (HP:0011473)2.99733194
37Abnormality of small intestinal villus morphology (HP:0011472)2.99733194
38Thin bony cortex (HP:0002753)2.98792272
39Insulin resistance (HP:0000855)2.98628059
40Ankyloglossia (HP:0010296)2.93221276
41Ventricular arrhythmia (HP:0004308)2.88827750
42Hyperammonemia (HP:0001987)2.88217506
43Prolonged QT interval (HP:0001657)2.87596698
44Pancreatitis (HP:0001733)2.85176586
45Recurrent gram-negative bacterial infections (HP:0005420)2.84382497
46Recurrent abscess formation (HP:0002722)2.84330896
47Pigmentary retinal degeneration (HP:0001146)2.84066030
48Nephritis (HP:0000123)2.75309959
49Symptomatic seizures (HP:0011145)2.71697134
50Abnormal biliary tract morphology (HP:0012440)2.70378290
51Exocrine pancreatic insufficiency (HP:0001738)2.66771361
52Hemorrhage of the eye (HP:0011885)2.65217453
53Recurrent bacterial skin infections (HP:0005406)2.64918046
54Bone cyst (HP:0012062)2.58024847
55Abnormal EKG (HP:0003115)2.57647888
56Hepatic necrosis (HP:0002605)2.57379319
57Increased muscle lipid content (HP:0009058)2.55345472
58Gingivitis (HP:0000230)2.51607793
59Hypoglycemic coma (HP:0001325)2.49680722
60Biliary tract neoplasm (HP:0100574)2.45419722
61Conjunctival hamartoma (HP:0100780)2.45124424
62Flat acetabular roof (HP:0003180)2.44542693
63Hypophosphatemia (HP:0002148)2.43452135
64Urticaria (HP:0001025)2.42709814
65Nephrolithiasis (HP:0000787)2.42233054
66Abnormality of the vitamin B12 metabolism (HP:0004341)2.41223704
67Polar cataract (HP:0010696)2.41174754
68Hyperphosphatemia (HP:0002905)2.40739315
69Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.39083126
70Potter facies (HP:0002009)2.36416246
71Facial shape deformation (HP:0011334)2.36416246
72Neoplasm of the rectum (HP:0100743)2.35738388
73Proximal tubulopathy (HP:0000114)2.34495438
74Esophageal varix (HP:0002040)2.34262825
75Hyperuricemia (HP:0002149)2.33208449
76Increased purine levels (HP:0004368)2.33208449
77Hepatocellular necrosis (HP:0001404)2.32494608
78Gastrointestinal dysmotility (HP:0002579)2.30112641
79Hypotension (HP:0002615)2.28650176
80Neoplasm of the small intestine (HP:0100833)2.25779929
81Abnormality of vitamin B metabolism (HP:0004340)2.25578838
82Abnormality of oral frenula (HP:0000190)2.24533084
83Xanthomatosis (HP:0000991)2.24518744
84Cheilitis (HP:0100825)2.22056455
85Hypobetalipoproteinemia (HP:0003563)2.19613522
86Premature loss of primary teeth (HP:0006323)2.17365434
87Poikiloderma (HP:0001029)2.16352623
88Increased intramyocellular lipid droplets (HP:0012240)2.16259457
89Periodontitis (HP:0000704)2.15590479
90Trismus (HP:0000211)2.15012407
91Focal segmental glomerulosclerosis (HP:0000097)2.14771794
92Cerebral palsy (HP:0100021)2.13403172
93Hyperglycinuria (HP:0003108)2.12611473
94Abnormality of chloride homeostasis (HP:0011422)2.07738942
95Palpitations (HP:0001962)2.05813410
96Abnormality of the gastric mucosa (HP:0004295)2.04656052
97Multifactorial inheritance (HP:0001426)2.01975697
98Glycosuria (HP:0003076)1.99597635
99Abnormality of urine glucose concentration (HP:0011016)1.99597635
100Abnormal glucose tolerance (HP:0001952)1.99163278
101Abnormality of nucleobase metabolism (HP:0010932)1.98003588
102Wide cranial sutures (HP:0010537)1.95695382
103Progressive hearing impairment (HP:0001730)1.95217313
104Abnormality of serine family amino acid metabolism (HP:0010894)1.95004769
105Abnormality of glycine metabolism (HP:0010895)1.95004769
106Enlarged epiphyses (HP:0010580)1.94017481
107Uterine neoplasm (HP:0010784)1.93672527
108Renal tubular acidosis (HP:0001947)1.93191755
109Dicarboxylic aciduria (HP:0003215)1.92010556
110Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92010556
111Malnutrition (HP:0004395)1.91307794
112Abnormality of aromatic amino acid family metabolism (HP:0004338)1.91063130
113Gout (HP:0001997)1.90584329
114Intrahepatic cholestasis (HP:0001406)1.89377728
115Protuberant abdomen (HP:0001538)1.88609273
116Abnormality of the nasal mucosa (HP:0000433)1.87904837
117Growth hormone excess (HP:0000845)1.87226844
118Abnormality of macrophages (HP:0004311)1.87166930
119Conjugated hyperbilirubinemia (HP:0002908)1.86991616
120Abnormality of pyrimidine metabolism (HP:0004353)1.86118083
121Petechiae (HP:0000967)1.85203145
122Abnormality of vitamin metabolism (HP:0100508)1.84506066
123Delayed epiphyseal ossification (HP:0002663)1.84249425
124Dehydration (HP:0001944)1.83566727
125Vasculitis (HP:0002633)1.83144477
126Gastrointestinal stroma tumor (HP:0100723)1.79587312
127Microretrognathia (HP:0000308)1.79325989
128Colitis (HP:0002583)1.78913304
129Pili torti (HP:0003777)1.78565821
130Hyperaldosteronism (HP:0000859)1.78481724
131Emphysema (HP:0002097)1.78454240
132Bone pain (HP:0002653)1.78045156
133Hyperparathyroidism (HP:0000843)1.75616393
134Increased mean platelet volume (HP:0011877)1.75548804
135Skin rash (HP:0000988)1.74984777
136Acanthocytosis (HP:0001927)1.74166186
137Hypokalemia (HP:0002900)1.73891705
138Confusion (HP:0001289)1.73648681
139Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72303504
140Vacuolated lymphocytes (HP:0001922)1.72093447
141Abnormality of purine metabolism (HP:0004352)1.71586002
142Widely patent fontanelles and sutures (HP:0004492)1.71401406
143Lethargy (HP:0001254)1.71020074
144Inflammation of the large intestine (HP:0002037)1.70979473
145Hypolipoproteinemia (HP:0010981)1.70594922
146Mitochondrial inheritance (HP:0001427)1.70563982
147Glomerulosclerosis (HP:0000096)1.70415154
148Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70362020
149Abnormal tarsal ossification (HP:0008369)1.70101186
150Hyperbilirubinemia (HP:0002904)1.69704947
151Acute encephalopathy (HP:0006846)1.69314544
152Gastrointestinal inflammation (HP:0004386)1.68376676
153Neoplasm of the colon (HP:0100273)1.66112405
154Nausea (HP:0002018)1.65575515
155Xerostomia (HP:0000217)1.65074679
156Abnormal mitochondria in muscle tissue (HP:0008316)1.64682103
157Abnormal platelet volume (HP:0011876)1.64541564
158Fragile skin (HP:0001030)1.62837260
159Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61522616
160Abnormality of monocarboxylic acid metabolism (HP:0010996)1.60310469
161Gastrointestinal carcinoma (HP:0002672)1.58980772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK26.33622467
2ACVR1B5.23188194
3MAP2K64.43604433
4MAP2K24.14932825
5PRKG23.13444888
6NME12.53144681
7EPHA32.39932819
8SCYL22.38190841
9MST1R2.31402939
10PKN22.31029408
11PIK3CA2.28589924
12FRK2.28194716
13GRK62.22574058
14TYK22.17803814
15PTK62.17168662
16TESK12.13726078
17MAP3K21.96636457
18MAPK151.94694778
19BLK1.85024955
20TRIB31.81724523
21STK241.76038492
22PTK21.66482694
23PAK41.65808460
24EPHB11.64689700
25STK391.60991462
26IRAK41.55305824
27MAP3K101.53012274
28MAP3K121.51715486
29PRPF4B1.45566165
30ERN11.45210276
31MAP3K111.44723152
32PDK21.43663274
33NME21.36944150
34FGFR31.36222540
35DDR21.36069585
36MAP3K31.33654522
37MST41.33200414
38CDC42BPA1.30074208
39BUB11.27983275
40NLK1.24889565
41RPS6KB21.24592683
42RIPK11.20029248
43KSR21.16560007
44MAP4K11.13101120
45BCKDK1.09170423
46RIPK41.09144656
47FER1.07474160
48MAP3K81.05846256
49CAMK2B1.05060262
50DAPK21.03036821
51JAK11.02242441
52MAP2K11.01971036
53VRK11.00843355
54IRAK11.00764258
55MAP3K140.97870831
56TESK20.95915840
57PIM20.95084863
58WNK40.94607876
59TAOK30.92861346
60ZAP700.91469886
61NEK20.91388192
62STK100.89836886
63CAMK2D0.87675419
64LRRK20.86116138
65TTK0.85743678
66EPHA20.83308332
67IKBKE0.81963119
68TGFBR20.81505415
69MAPK110.80448482
70CAMK2G0.77471225
71TNIK0.77126507
72OXSR10.76672727
73MAP3K10.75190420
74DYRK1B0.74029419
75BMPR20.73099434
76TBK10.72840685
77TAOK10.71889936
78CSK0.71775465
79AURKB0.70619604
80MAPK40.70340569
81PBK0.69094541
82NEK10.68621354
83JAK20.64682374
84KIT0.64582197
85ERBB20.63986607
86JAK30.63684104
87PRKAA20.62485209
88IRAK30.61827836
89CAMKK10.60875686
90FGFR40.59977751
91PAK10.59004026
92MET0.58295836
93TTN0.55479726
94NUAK10.54765879
95RET0.53437614
96RAF10.52897751
97MYLK0.52192745
98GRK10.51968248
99PRKCD0.51486512
100PRKCQ0.49598357
101PDGFRA0.48597228
102FES0.48499076
103YES10.48134366
104LIMK10.47803237
105MAP2K30.46530536
106CDK190.46150519
107TLK10.44989570
108MAP3K90.44482834
109PDPK10.42119715
110KDR0.42097918
111BMX0.41919633
112FYN0.40918180
113LYN0.40400965
114TRPM70.40338427
115AKT30.37592718
116SYK0.36660347
117EPHB20.35464179
118BTK0.35088955
119DMPK0.34968000
120PRKCZ0.34828580
121EEF2K0.33139030
122ILK0.32831891
123MATK0.32659077
124SMG10.31536678
125ITK0.30631751
126HIPK20.30400885
127SRC0.29163073
128PRKCA0.28159838
129MAPKAPK20.27900734
130ABL20.27648387
131CSF1R0.26445068
132PRKCI0.26377457
133PRKACG0.26003904
134CDK60.24865922
135MAPK70.24853754
136STK110.24528092
137TEC0.24225931
138LCK0.24224615
139PASK0.23876600
140IGF1R0.22019001
141CDK11A0.21372663
142FGR0.21206096
143PRKCB0.20857990
144CDK150.20311314
145PDK10.19708143
146RPS6KA20.19089620
147PIK3CG0.18879760

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000535.40725576
2Histidine metabolism_Homo sapiens_hsa003404.08454524
3Nitrogen metabolism_Homo sapiens_hsa009103.99921194
4Pentose and glucuronate interconversions_Homo sapiens_hsa000403.93125925
5Maturity onset diabetes of the young_Homo sapiens_hsa049503.77244343
6Arginine and proline metabolism_Homo sapiens_hsa003302.95221632
7Fatty acid degradation_Homo sapiens_hsa000712.80172459
8Tryptophan metabolism_Homo sapiens_hsa003802.62112966
9Pyruvate metabolism_Homo sapiens_hsa006202.60147586
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.44062216
11beta-Alanine metabolism_Homo sapiens_hsa004102.30963224
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.13641052
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12623824
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.10217168
15Cyanoamino acid metabolism_Homo sapiens_hsa004602.09491451
16Fat digestion and absorption_Homo sapiens_hsa049751.93697586
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.93219422
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.88692023
19Asthma_Homo sapiens_hsa053101.87666903
20Fructose and mannose metabolism_Homo sapiens_hsa000511.86478628
21Linoleic acid metabolism_Homo sapiens_hsa005911.79580198
22Pentose phosphate pathway_Homo sapiens_hsa000301.77737682
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.68958348
24Glutathione metabolism_Homo sapiens_hsa004801.68936634
25Arginine biosynthesis_Homo sapiens_hsa002201.52058741
26Staphylococcus aureus infection_Homo sapiens_hsa051501.52021725
27Glycerolipid metabolism_Homo sapiens_hsa005611.50266188
28Carbon metabolism_Homo sapiens_hsa012001.37592611
29Parkinsons disease_Homo sapiens_hsa050121.35237574
30Oxidative phosphorylation_Homo sapiens_hsa001901.33569283
31Allograft rejection_Homo sapiens_hsa053301.31381857
32Sulfur metabolism_Homo sapiens_hsa009201.30069343
33Leishmaniasis_Homo sapiens_hsa051401.29637093
34Insulin secretion_Homo sapiens_hsa049111.29400506
35Galactose metabolism_Homo sapiens_hsa000521.26817038
36Autoimmune thyroid disease_Homo sapiens_hsa053201.23671754
37Graft-versus-host disease_Homo sapiens_hsa053321.17317112
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.16924667
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15376849
40Ether lipid metabolism_Homo sapiens_hsa005651.10993410
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07841326
42Biosynthesis of amino acids_Homo sapiens_hsa012301.04163313
43Type I diabetes mellitus_Homo sapiens_hsa049401.03956055
44Lysine degradation_Homo sapiens_hsa003101.03577978
45Alzheimers disease_Homo sapiens_hsa050100.98561248
46Hepatitis C_Homo sapiens_hsa051600.96399418
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93285398
48Folate biosynthesis_Homo sapiens_hsa007900.93272309
49Bladder cancer_Homo sapiens_hsa052190.92608528
50Tight junction_Homo sapiens_hsa045300.88930753
51Vibrio cholerae infection_Homo sapiens_hsa051100.88518734
52Pertussis_Homo sapiens_hsa051330.88412135
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86532775
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85643019
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84415739
56Mineral absorption_Homo sapiens_hsa049780.82666053
57Salmonella infection_Homo sapiens_hsa051320.80035974
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79403367
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76510920
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76475322
61Antigen processing and presentation_Homo sapiens_hsa046120.73805219
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71104747
63Starch and sucrose metabolism_Homo sapiens_hsa005000.71071128
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69888103
65Pancreatic secretion_Homo sapiens_hsa049720.69194417
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.68542226
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67543109
68Huntingtons disease_Homo sapiens_hsa050160.64610139
69Gastric acid secretion_Homo sapiens_hsa049710.63925869
70Thyroid hormone synthesis_Homo sapiens_hsa049180.63875142
71Protein digestion and absorption_Homo sapiens_hsa049740.63870032
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.60884200
73Bile secretion_Homo sapiens_hsa049760.59229635
74Arachidonic acid metabolism_Homo sapiens_hsa005900.56514513
75Shigellosis_Homo sapiens_hsa051310.56410100
76Other glycan degradation_Homo sapiens_hsa005110.54239092
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51366396
78VEGF signaling pathway_Homo sapiens_hsa043700.50136424
79Propanoate metabolism_Homo sapiens_hsa006400.49390659
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47779323
81Toxoplasmosis_Homo sapiens_hsa051450.47474473
82Sulfur relay system_Homo sapiens_hsa041220.46709384
83Viral myocarditis_Homo sapiens_hsa054160.46055784
84Vitamin digestion and absorption_Homo sapiens_hsa049770.42617315
85Butanoate metabolism_Homo sapiens_hsa006500.42270066
86Phenylalanine metabolism_Homo sapiens_hsa003600.42129093
87ABC transporters_Homo sapiens_hsa020100.40956448
88Renin secretion_Homo sapiens_hsa049240.39053867
89Hematopoietic cell lineage_Homo sapiens_hsa046400.38051161
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36289640
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.35899661
92Complement and coagulation cascades_Homo sapiens_hsa046100.35015544
93Fatty acid metabolism_Homo sapiens_hsa012120.34817397
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34770823
95Caffeine metabolism_Homo sapiens_hsa002320.33062187
96Osteoclast differentiation_Homo sapiens_hsa043800.32684483
97Metabolic pathways_Homo sapiens_hsa011000.32109447
98Selenocompound metabolism_Homo sapiens_hsa004500.31012874
99Legionellosis_Homo sapiens_hsa051340.30554178
100African trypanosomiasis_Homo sapiens_hsa051430.30390504
101Rheumatoid arthritis_Homo sapiens_hsa053230.30321527
102Chemokine signaling pathway_Homo sapiens_hsa040620.30171100
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29819792
104DNA replication_Homo sapiens_hsa030300.28668711
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28592130
106Fatty acid biosynthesis_Homo sapiens_hsa000610.28177935
107Influenza A_Homo sapiens_hsa051640.27955623
108Renin-angiotensin system_Homo sapiens_hsa046140.27766567
109Cardiac muscle contraction_Homo sapiens_hsa042600.27101787
110Insulin resistance_Homo sapiens_hsa049310.25888962
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.25624208
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24570726
113Tuberculosis_Homo sapiens_hsa051520.23317287
114GnRH signaling pathway_Homo sapiens_hsa049120.22028321
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.21872876
116Amoebiasis_Homo sapiens_hsa051460.21720784
117Fatty acid elongation_Homo sapiens_hsa000620.21349199
118Peroxisome_Homo sapiens_hsa041460.20685563
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.20603627
120Sphingolipid metabolism_Homo sapiens_hsa006000.19878906
121Ribosome_Homo sapiens_hsa030100.17893981
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17707854
123Retinol metabolism_Homo sapiens_hsa008300.17405755
124Tyrosine metabolism_Homo sapiens_hsa003500.17366044
125TNF signaling pathway_Homo sapiens_hsa046680.16367661
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16198857
127Chemical carcinogenesis_Homo sapiens_hsa052040.15994956
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.14268423
129PPAR signaling pathway_Homo sapiens_hsa033200.14195029
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14093562
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.13826539
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.12851928
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11660825
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.10492654
135Herpes simplex infection_Homo sapiens_hsa051680.08224596
136Phagosome_Homo sapiens_hsa041450.07351944

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