OLFM5P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)8.89571068
2sperm capacitation (GO:0048240)8.80581625
3DNA packaging (GO:0006323)8.74420115
4spermatid nucleus differentiation (GO:0007289)8.41741098
5response to pheromone (GO:0019236)8.39890340
6single strand break repair (GO:0000012)7.69962822
7spermatid development (GO:0007286)7.65445855
8plasma membrane fusion (GO:0045026)7.64093646
9microtubule depolymerization (GO:0007019)6.91053767
10sperm-egg recognition (GO:0035036)6.83106116
11sexual reproduction (GO:0019953)6.72255541
12multicellular organism reproduction (GO:0032504)6.71997367
13reproduction (GO:0000003)6.48099087
14protein targeting to Golgi (GO:0000042)6.40396952
15phosphatidylethanolamine biosynthetic process (GO:0006646)6.32283758
16microtubule severing (GO:0051013)6.27076142
17establishment of protein localization to Golgi (GO:0072600)6.24686759
18protein polyglutamylation (GO:0018095)6.21128342
19negative regulation of inclusion body assembly (GO:0090084)6.19826082
20binding of sperm to zona pellucida (GO:0007339)6.15354772
21rRNA methylation (GO:0031167)6.03657978
22retrograde transport, vesicle recycling within Golgi (GO:0000301)5.96461250
23phosphatidylethanolamine metabolic process (GO:0046337)5.95513903
24calcium ion-dependent exocytosis (GO:0017156)5.84788852
25microtubule polymerization or depolymerization (GO:0031109)5.84470674
26axonemal dynein complex assembly (GO:0070286)5.83421225
27cellular ketone body metabolic process (GO:0046950)5.72372117
28positive regulation of Rab GTPase activity (GO:0032851)5.66484285
29regulation of Rab GTPase activity (GO:0032313)5.66484285
30cell-cell recognition (GO:0009988)5.66286976
31spermatogenesis (GO:0007283)5.59718444
32male gamete generation (GO:0048232)5.57392495
33cilium or flagellum-dependent cell motility (GO:0001539)5.52612787
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.37824993
35centriole replication (GO:0007099)5.24484244
36regulation of cilium movement (GO:0003352)5.15000295
37gamete generation (GO:0007276)5.08449465
38ketone body metabolic process (GO:1902224)5.01344635
39chromatin silencing (GO:0006342)5.00323673
40rRNA modification (GO:0000154)4.83720413
41regulation of transcription involved in cell fate commitment (GO:0060850)4.72906827
42seminiferous tubule development (GO:0072520)4.53262595
43protein localization to Golgi apparatus (GO:0034067)4.51138027
44single fertilization (GO:0007338)4.44963361
45regulation of inclusion body assembly (GO:0090083)4.44219912
46centriole assembly (GO:0098534)4.41350149
47germ cell development (GO:0007281)4.28827850
48negative regulation of Rho protein signal transduction (GO:0035024)4.25912192
49RNA destabilization (GO:0050779)4.21162037
50motile cilium assembly (GO:0044458)4.20360527
51cell wall macromolecule catabolic process (GO:0016998)4.18995915
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.17267121
53cell wall macromolecule metabolic process (GO:0044036)4.14614385
54nucleus organization (GO:0006997)4.10305810
55multicellular organismal reproductive process (GO:0048609)4.07038680
56epithelial cilium movement (GO:0003351)3.96902461
57fertilization (GO:0009566)3.72697162
58glycerol ether metabolic process (GO:0006662)3.69839104
59cilium movement (GO:0003341)3.58830059
60regulation of centriole replication (GO:0046599)3.55143360
61protein-DNA complex disassembly (GO:0032986)3.54586157
62nucleosome disassembly (GO:0006337)3.54586157
63negative regulation of gene expression, epigenetic (GO:0045814)3.43498980
64cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.38197742
65ether metabolic process (GO:0018904)3.37937149
66organic cation transport (GO:0015695)3.37519759
67regulation of T-helper 2 cell differentiation (GO:0045628)3.36922623
68regulation of microtubule-based movement (GO:0060632)3.29765629
69response to acidic pH (GO:0010447)3.28343752
70cellular response to pH (GO:0071467)3.21496295
71histone H3-K9 demethylation (GO:0033169)3.18882866
72homeostasis of number of cells within a tissue (GO:0048873)3.15002131
73peptidyl-threonine dephosphorylation (GO:0035970)3.14712389
74musculoskeletal movement (GO:0050881)3.13738008
75multicellular organismal movement (GO:0050879)3.13738008
76coenzyme catabolic process (GO:0009109)3.12004969
77polyamine biosynthetic process (GO:0006596)3.09135319
78microtubule nucleation (GO:0007020)3.09090732
79Golgi to endosome transport (GO:0006895)3.07684083
80centrosome duplication (GO:0051298)3.03607337
81membrane protein intracellular domain proteolysis (GO:0031293)3.02408374
82regulation of histone H3-K27 methylation (GO:0061085)3.00526316
83regulation of interleukin-13 production (GO:0032656)2.99682892
84coronary vasculature morphogenesis (GO:0060977)2.98475845
85multicellular organismal development (GO:0007275)2.97361903
86regulation of ARF GTPase activity (GO:0032312)2.94929933
87mesenchymal cell differentiation involved in kidney development (GO:0072161)2.89599050
88mesenchymal cell differentiation involved in renal system development (GO:2001012)2.89599050
89cranial nerve morphogenesis (GO:0021602)2.87409229
90negative regulation of histone methylation (GO:0031061)2.87233934
91alanine transport (GO:0032328)2.86043530
92regulation of cilium assembly (GO:1902017)2.83464039
93cerebral cortex neuron differentiation (GO:0021895)2.79175096
94left/right axis specification (GO:0070986)2.77631679
95DNA conformation change (GO:0071103)2.76243596
96NAD biosynthetic process (GO:0009435)2.73518841
97negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.73398059
98acrosome reaction (GO:0007340)11.0335409
99sperm motility (GO:0030317)10.9996237
100fusion of sperm to egg plasma membrane (GO:0007342)10.2468428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.45860935
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77691815
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.70037973
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35619090
5VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.18677586
6ELF1_20517297_ChIP-Seq_JURKAT_Human2.10791659
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08546213
8DROSHA_22980978_ChIP-Seq_HELA_Human2.07891806
9CBP_20019798_ChIP-Seq_JUKART_Human2.03441356
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.03441356
11CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92531618
12CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91158252
13TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89531056
14POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.89531056
15WDR5_24793694_ChIP-Seq_LNCAP_Human1.84631342
16ER_23166858_ChIP-Seq_MCF-7_Human1.75256489
17RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.72485396
18ERA_21632823_ChIP-Seq_H3396_Human1.72008624
19UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70645414
20FUS_26573619_Chip-Seq_HEK293_Human1.69151550
21NANOG_20526341_ChIP-Seq_ESCs_Human1.68196614
22EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.66447872
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.65188728
24RAC3_21632823_ChIP-Seq_H3396_Human1.62196551
25EZH2_22144423_ChIP-Seq_EOC_Human1.61268811
26ARNT_22903824_ChIP-Seq_MCF-7_Human1.56765165
27BCL6_27268052_Chip-Seq_Bcells_Human1.55175581
28AR_25329375_ChIP-Seq_VCAP_Human1.55168004
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54663410
30AUTS2_25519132_ChIP-Seq_293T-REX_Human1.50477415
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.47485829
32RUNX_20019798_ChIP-Seq_JUKART_Human1.46532801
33EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.45551661
34BCOR_27268052_Chip-Seq_Bcells_Human1.44373579
35SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44369412
36ETV2_25802403_ChIP-Seq_MESCs_Mouse1.42515972
37CTCF_27219007_Chip-Seq_Bcells_Human1.41665919
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41036245
39E2F1_20622854_ChIP-Seq_HELA_Human1.40725194
40TAF2_19829295_ChIP-Seq_ESCs_Human1.40108798
41TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39216529
42SMAD4_21741376_ChIP-Seq_EPCs_Human1.39067296
43PHF8_20622854_ChIP-Seq_HELA_Human1.38763585
44MYC_19829295_ChIP-Seq_ESCs_Human1.38334432
45YY1_22570637_ChIP-Seq_MALME-3M_Human1.36208375
46SMC4_20622854_ChIP-Seq_HELA_Human1.34246329
47OCT4_20526341_ChIP-Seq_ESCs_Human1.33537660
48P300_27268052_Chip-Seq_Bcells_Human1.32187347
49P68_20966046_ChIP-Seq_HELA_Human1.30884831
50ETV1_20927104_ChIP-Seq_GIST48_Human1.29678779
51ERG_20517297_ChIP-Seq_VCAP_Human1.28402417
52SMRT_27268052_Chip-Seq_Bcells_Human1.28276324
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.28033811
54TP63_22573176_ChIP-Seq_HFKS_Human1.27290218
55ZNF274_21170338_ChIP-Seq_K562_Hela1.26558678
56SMAD3_21741376_ChIP-Seq_ESCs_Human1.26410342
57P300_19829295_ChIP-Seq_ESCs_Human1.23559523
58LXR_22292898_ChIP-Seq_THP-1_Human1.22920381
59CBX2_22325352_ChIP-Seq_293T-Rex_Human1.22483727
60KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.20414575
61RBPJ_21746931_ChIP-Seq_IB4_Human1.19261155
62HNFA_21074721_ChIP-Seq_CACO-2_Human1.18943239
63CEBPB_22108803_ChIP-Seq_LS180_Human1.17860571
64CTCF_20526341_ChIP-Seq_ESCs_Human1.17766526
65CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.17313684
66TP53_18474530_ChIP-ChIP_U2OS_Human1.17235170
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16806970
68RUNX2_22187159_ChIP-Seq_PCA_Human1.16263939
69GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15343659
70SMAD4_21741376_ChIP-Seq_HESCs_Human1.15144926
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.14819303
72OCT1_27270436_Chip-Seq_PROSTATE_Human1.12798092
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11931406
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08853008
75TAF15_26573619_Chip-Seq_HEK293_Human1.08325437
76TBL1_22424771_ChIP-Seq_293T_Human1.08007382
77STAT3_23295773_ChIP-Seq_U87_Human1.07483176
78VDR_24787735_ChIP-Seq_THP-1_Human1.07068072
79JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06819490
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06561220
81P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.06075469
82GATA3_26560356_Chip-Seq_TH1_Human1.05866249
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05767556
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.05572897
85GATA1_19941826_ChIP-Seq_K562_Human1.05496336
86NANOG_19829295_ChIP-Seq_ESCs_Human1.04954341
87SOX2_19829295_ChIP-Seq_ESCs_Human1.04954341
88NFYB_21822215_ChIP-Seq_K562_Human1.03995192
89RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03364289
90PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.03325152
91CJUN_26792858_Chip-Seq_BT549_Human1.00944948
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00880406
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00738169
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99890618
95IRF8_22096565_ChIP-ChIP_GC-B_Human0.98871120
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98601437
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97202922
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96183991
99SMAD4_21799915_ChIP-Seq_A2780_Human0.95566221
100P53_21459846_ChIP-Seq_SAOS-2_Human0.94958347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.27032420
2MP0005377_hearing/vestibular/ear_phenot4.52922133
3MP0003878_abnormal_ear_physiology4.52922133
4MP0003698_abnormal_male_reproductive4.29694142
5MP0001348_abnormal_lacrimal_gland4.04885950
6MP0001929_abnormal_gametogenesis3.69294701
7MP0003011_delayed_dark_adaptation2.68396790
8MP0002161_abnormal_fertility/fecundity2.32422724
9MP0000678_abnormal_parathyroid_gland2.21933582
10MP0002132_abnormal_respiratory_system2.17102304
11MP0005410_abnormal_fertilization12.0621797
12MP0003646_muscle_fatigue1.90280867
13MP0001485_abnormal_pinna_reflex1.81868777
14MP0005310_abnormal_salivary_gland1.81318442
15MP0003718_maternal_effect1.67803455
16MP0005379_endocrine/exocrine_gland_phen1.63849680
17MP0002249_abnormal_larynx_morphology1.63385818
18MP0002282_abnormal_trachea_morphology1.54091728
19MP0002210_abnormal_sex_determination1.43307003
20MP0000534_abnormal_ureter_morphology1.36964866
21MP0009053_abnormal_anal_canal1.31567284
22MP0001145_abnormal_male_reproductive1.22379011
23MP0002928_abnormal_bile_duct1.21285879
24MP0002127_abnormal_cardiovascular_syste1.20866675
25MP0000653_abnormal_sex_gland1.20189141
26MP0005248_abnormal_Harderian_gland1.17836973
27MP0005423_abnormal_somatic_nervous1.14252948
28MP0000681_abnormal_thyroid_gland1.14023801
29MP0001486_abnormal_startle_reflex1.11197402
30MP0002138_abnormal_hepatobiliary_system1.09779106
31MP0005167_abnormal_blood-brain_barrier1.08301463
32MP0005666_abnormal_adipose_tissue1.06562445
33MP0001765_abnormal_ion_homeostasis1.06538182
34MP0004484_altered_response_of1.06534037
35MP0002735_abnormal_chemical_nociception1.06406973
36MP0004782_abnormal_surfactant_physiolog1.06015726
37MP0005451_abnormal_body_composition1.00921361
38MP0008961_abnormal_basal_metabolism1.00055033
39MP0009115_abnormal_fat_cell0.96328241
40MP0001963_abnormal_hearing_physiology0.95937545
41MP0001968_abnormal_touch/_nociception0.92387624
42MP0005395_other_phenotype0.92106169
43MP0005367_renal/urinary_system_phenotyp0.86940312
44MP0000516_abnormal_urinary_system0.86940312
45MP0000026_abnormal_inner_ear0.86892773
46MP0000569_abnormal_digit_pigmentation0.79401093
47MP0000049_abnormal_middle_ear0.79253911
48MP0002234_abnormal_pharynx_morphology0.77698626
49MP0004859_abnormal_synaptic_plasticity0.77566083
50MP0005551_abnormal_eye_electrophysiolog0.73108815
51MP0001873_stomach_inflammation0.72771053
52MP0008877_abnormal_DNA_methylation0.72670656
53MP0002822_catalepsy0.71455214
54MP0008569_lethality_at_weaning0.71263083
55MP0004742_abnormal_vestibular_system0.69260922
56MP0000249_abnormal_blood_vessel0.66759119
57MP0003091_abnormal_cell_migration0.64844776
58MP0005164_abnormal_response_to0.64483945
59MP0004510_myositis0.63298218
60MP0009764_decreased_sensitivity_to0.62165264
61MP0002733_abnormal_thermal_nociception0.57493207
62MP0005375_adipose_tissue_phenotype0.57425734
63MP0006292_abnormal_olfactory_placode0.57109755
64MP0005647_abnormal_sex_gland0.55688060
65MP0003172_abnormal_lysosome_physiology0.55352846
66MP0000955_abnormal_spinal_cord0.55132122
67MP0001879_abnormal_lymphatic_vessel0.55052846
68MP0002229_neurodegeneration0.54694799
69MP0001835_abnormal_antigen_presentation0.53429859
70MP0005636_abnormal_mineral_homeostasis0.52396919
71MP0005535_abnormal_body_temperature0.51876369
72MP0000470_abnormal_stomach_morphology0.51547139
73MP0002168_other_aberrant_phenotype0.47571736
74MP0003879_abnormal_hair_cell0.46770015
75MP0001545_abnormal_hematopoietic_system0.46558916
76MP0005397_hematopoietic_system_phenotyp0.46558916
77MP0005253_abnormal_eye_physiology0.46040467
78MP0001614_abnormal_blood_vessel0.44150412
79MP0000230_abnormal_systemic_arterial0.43454922
80MP0004085_abnormal_heartbeat0.41630225
81MP0002933_joint_inflammation0.41480609
82MP0002653_abnormal_ependyma_morphology0.40949500
83MP0003221_abnormal_cardiomyocyte_apopto0.40810806
84MP0002067_abnormal_sensory_capabilities0.40514377
85MP0009765_abnormal_xenobiotic_induced0.40310252
86MP0001270_distended_abdomen0.40131296
87MP0001175_abnormal_lung_morphology0.39414961
88MP0009384_cardiac_valve_regurgitation0.39275998
89MP0002419_abnormal_innate_immunity0.39148066
90MP0008995_early_reproductive_senescence0.38001678
91MP0004084_abnormal_cardiac_muscle0.37902407
92MP0000467_abnormal_esophagus_morphology0.37446017
93MP0005623_abnormal_meninges_morphology0.36041133
94MP0005595_abnormal_vascular_smooth0.35917159
95MP0002925_abnormal_cardiovascular_devel0.35215534
96MP0000685_abnormal_immune_system0.35102860
97MP0003724_increased_susceptibility_to0.35015865
98MP0004133_heterotaxia0.34431378
99MP0001533_abnormal_skeleton_physiology0.34232998
100MP0005174_abnormal_tail_pigmentation0.32438348

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.42936035
2Absent/shortened dynein arms (HP:0200106)5.83412483
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.83412483
4Asymmetric septal hypertrophy (HP:0001670)5.18720541
5Abnormal ciliary motility (HP:0012262)4.83623688
6Bony spicule pigmentary retinopathy (HP:0007737)4.70269947
7Attenuation of retinal blood vessels (HP:0007843)4.64351991
8Abnormal respiratory epithelium morphology (HP:0012253)4.60260524
9Abnormal respiratory motile cilium morphology (HP:0005938)4.60260524
10Tubulointerstitial nephritis (HP:0001970)4.54333796
11Abnormal respiratory motile cilium physiology (HP:0012261)4.43206047
12Nasal polyposis (HP:0100582)4.36864297
13Hyperkalemia (HP:0002153)4.32151769
14Chronic hepatic failure (HP:0100626)4.25690182
15Bell-shaped thorax (HP:0001591)4.21054948
16Hypoplastic ischia (HP:0003175)4.18167426
17Male infertility (HP:0003251)4.02771603
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.98977206
19Abnormality of the ischium (HP:0003174)3.83070374
20Infertility (HP:0000789)3.78609102
21Abnormal rod and cone electroretinograms (HP:0008323)3.69970773
22Abnormality of the nasal mucosa (HP:0000433)3.66073854
23Resting tremor (HP:0002322)3.56543993
24Enlarged epiphyses (HP:0010580)3.56141314
25Potter facies (HP:0002009)3.53063784
26Facial shape deformation (HP:0011334)3.53063784
27Aplasia/Hypoplasia of the earlobes (HP:0009906)3.44415863
28Abnormality of macular pigmentation (HP:0008002)3.32893791
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.31001799
30Azoospermia (HP:0000027)3.29819543
31Hypoalphalipoproteinemia (HP:0003233)3.19069042
32Abnormal spermatogenesis (HP:0008669)3.17115141
33Impulsivity (HP:0100710)3.06115821
34Cone-rod dystrophy (HP:0000548)3.04930005
35Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.96354109
36Portal hypertension (HP:0001409)2.88111351
37Progressive sensorineural hearing impairment (HP:0000408)2.86440468
38Abnormality of the costochondral junction (HP:0000919)2.85721903
39Abnormality of potassium homeostasis (HP:0011042)2.67282100
40Abnormality of the hepatic vasculature (HP:0006707)2.61411439
41Nephronophthisis (HP:0000090)2.55692284
42Abnormality of dental color (HP:0011073)2.52066949
43Hypoplasia of the thymus (HP:0000778)2.46417929
44Amelogenesis imperfecta (HP:0000705)2.46399533
45Stage 5 chronic kidney disease (HP:0003774)2.46227939
46Rhinitis (HP:0012384)2.44702410
47Truncal obesity (HP:0001956)2.42737983
48Insulin-resistant diabetes mellitus (HP:0000831)2.37710322
49Osteomalacia (HP:0002749)2.37093699
50Bronchiectasis (HP:0002110)2.35103051
51Abnormal urine output (HP:0012590)2.34786152
52Progressive cerebellar ataxia (HP:0002073)2.28897439
53Abnormality of the aortic arch (HP:0012303)2.28809242
54Cerebellar dysplasia (HP:0007033)2.27311174
55Recurrent pneumonia (HP:0006532)2.27272729
56Abnormality of the renal medulla (HP:0100957)2.27173709
57Renal dysplasia (HP:0000110)2.24889111
58Tetany (HP:0001281)2.20572159
59Hyponatremia (HP:0002902)2.18279288
60Atelectasis (HP:0100750)2.15179893
61Tubulointerstitial abnormality (HP:0001969)2.14863432
62Postural instability (HP:0002172)2.11256671
63Abnormality of renal excretion (HP:0011036)1.94113916
64Abnormality of the parathyroid morphology (HP:0011766)1.91229651
65Abnormal drinking behavior (HP:0030082)1.90561472
66Polydipsia (HP:0001959)1.90561472
67Short ribs (HP:0000773)1.90079089
68Epiphyseal dysplasia (HP:0002656)1.88276903
69Unilateral renal agenesis (HP:0000122)1.87829823
70Neonatal short-limb short stature (HP:0008921)1.87647035
71Progressive hearing impairment (HP:0001730)1.87486723
72Hypoparathyroidism (HP:0000829)1.87422438
73Gingivitis (HP:0000230)1.85834677
74Renovascular hypertension (HP:0100817)1.85599633
75Flattened epiphyses (HP:0003071)1.83950809
76Widely patent fontanelles and sutures (HP:0004492)1.83274831
77Recurrent corneal erosions (HP:0000495)1.82015674
78Congenital malformation of the right heart (HP:0011723)1.80660086
79Double outlet right ventricle (HP:0001719)1.80660086
80Hypokalemia (HP:0002900)1.80498952
81Polyuria (HP:0000103)1.79277807
82Hypochromic microcytic anemia (HP:0004840)1.78999917
83Hyperthyroidism (HP:0000836)1.78942288
84Flat capital femoral epiphysis (HP:0003370)1.78698013
85Abnormality of the pubic bones (HP:0003172)1.77350631
86Genetic anticipation (HP:0003743)1.77190401
87Ventricular tachycardia (HP:0004756)1.73456215
88Hypophosphatemic rickets (HP:0004912)1.66652415
89Intellectual disability, moderate (HP:0002342)1.66108361
90Short phalanx of the thumb (HP:0009660)1.65548488
91Macular degeneration (HP:0000608)1.65463190
92Abnormality of sodium homeostasis (HP:0010931)1.64544624
93Menstrual irregularities (HP:0000858)1.63445145
94Generalized aminoaciduria (HP:0002909)1.62847460
95Increased purine levels (HP:0004368)1.60841575
96Hyperuricemia (HP:0002149)1.60841575
97Bowel incontinence (HP:0002607)1.59943238
98Protuberant abdomen (HP:0001538)1.55886030
99Sandal gap (HP:0001852)1.55612987
100Reticulocytosis (HP:0001923)1.54013054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.36875592
2TESK15.29407044
3DDR25.03244288
4PNCK3.74757538
5STK383.52379329
6MAP4K22.71240347
7MAPK152.63425617
8BRD42.59454337
9INSRR2.55396499
10PLK22.37991546
11STK38L2.06475174
12PIK3CG2.02561449
13CAMK1G1.89819874
14PRKD31.88328062
15DYRK1B1.83094810
16WNK11.71476928
17MST1R1.39016571
18PDK11.38264910
19MAP3K71.37469460
20PDPK11.34443874
21RIPK41.32285499
22PTK2B1.30364058
23PKN21.28885973
24SIK21.27548016
25KSR21.24318683
26MARK21.07649936
27BRSK21.07579824
28CDK121.06664937
29AKT31.04097512
30TNK21.01248662
31JAK30.99493251
32MUSK0.96832576
33NEK60.90267703
34CAMK10.86407679
35PRKAA20.84689620
36CDK70.81177440
37PRKG20.81115926
38STK390.77447198
39KIT0.73863372
40MAP3K10.73387509
41RPS6KA20.73169409
42FLT30.72203950
43ROCK10.72158264
44RPS6KA10.68110392
45PRKG10.62244112
46BRAF0.61335477
47MAP3K20.61271667
48MAP2K20.61210030
49RPS6KL10.57799660
50RPS6KC10.57799660
51FER0.56070502
52WNK40.53258113
53MAPK110.52830931
54MAP3K80.51305383
55RPS6KA60.51230934
56BLK0.50652237
57TEC0.50348541
58CAMK40.49165554
59CAMKK20.47369258
60BMPR20.45888217
61LATS10.44171689
62GSK3B0.44053270
63CLK10.43203546
64MAPK10.41944183
65CAMK1D0.41861866
66MAPK80.39739270
67CDK40.39369484
68MAP2K70.38925372
69MAP3K40.38795484
70MAP3K90.38358858
71CDK20.34558805
72MTOR0.33616178
73BRSK10.33210673
74WNK30.33148333
75UHMK10.32410329
76PKN10.31604031
77TRPM70.30385902
78MAPK100.30162877
79BMPR1B0.28977703
80PBK0.28623379
81ERN10.28176717
82JAK20.27483260
83LATS20.27277381
84CDK10.26872337
85PRKCB0.26335114
86OXSR10.25420057
87ITK0.25241654
88RET0.25208270
89HCK0.24514697
90TXK0.24328284
91NTRK30.23465946
92NEK90.22443476
93CHEK10.21875615
94MAP3K130.21784941
95FES0.20186523
96CDK30.19981668
97PRKAA10.19952267
98CSK0.19748810
99SGK10.19080869
100ERBB30.17299441

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.73467681
2Fatty acid biosynthesis_Homo sapiens_hsa000614.49841525
3Olfactory transduction_Homo sapiens_hsa047403.39624163
4Butanoate metabolism_Homo sapiens_hsa006502.49585551
5Autoimmune thyroid disease_Homo sapiens_hsa053201.95448918
6Dorso-ventral axis formation_Homo sapiens_hsa043201.92054615
7Allograft rejection_Homo sapiens_hsa053301.85428314
8Graft-versus-host disease_Homo sapiens_hsa053321.74681094
9Glycerophospholipid metabolism_Homo sapiens_hsa005641.71639311
10Type I diabetes mellitus_Homo sapiens_hsa049401.70876840
11Antigen processing and presentation_Homo sapiens_hsa046121.59414129
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.57196866
13ABC transporters_Homo sapiens_hsa020101.55196286
14Inositol phosphate metabolism_Homo sapiens_hsa005621.39436755
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38678104
16Taste transduction_Homo sapiens_hsa047421.37637694
17Viral myocarditis_Homo sapiens_hsa054161.37613645
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21104105
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18503128
20Influenza A_Homo sapiens_hsa051641.11886014
21Type II diabetes mellitus_Homo sapiens_hsa049301.10926924
22Protein digestion and absorption_Homo sapiens_hsa049741.10657714
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09843274
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09624067
25Vitamin B6 metabolism_Homo sapiens_hsa007501.08713273
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05330124
27Endocytosis_Homo sapiens_hsa041441.04398532
28Phenylalanine metabolism_Homo sapiens_hsa003601.00560085
29Fatty acid degradation_Homo sapiens_hsa000710.99897220
30Circadian rhythm_Homo sapiens_hsa047100.98833584
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97372342
32Adipocytokine signaling pathway_Homo sapiens_hsa049200.95680044
33Estrogen signaling pathway_Homo sapiens_hsa049150.92931748
34Hedgehog signaling pathway_Homo sapiens_hsa043400.92471039
35Salivary secretion_Homo sapiens_hsa049700.92322211
36Glycerolipid metabolism_Homo sapiens_hsa005610.83239425
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80713375
38Jak-STAT signaling pathway_Homo sapiens_hsa046300.80704583
39Calcium signaling pathway_Homo sapiens_hsa040200.79972711
40Acute myeloid leukemia_Homo sapiens_hsa052210.73427744
41Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72287869
42Morphine addiction_Homo sapiens_hsa050320.70582932
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67345337
44Circadian entrainment_Homo sapiens_hsa047130.65234143
45B cell receptor signaling pathway_Homo sapiens_hsa046620.63883078
46MAPK signaling pathway_Homo sapiens_hsa040100.63179055
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62705449
48RNA transport_Homo sapiens_hsa030130.61729016
49Phototransduction_Homo sapiens_hsa047440.60944727
50cAMP signaling pathway_Homo sapiens_hsa040240.60549377
51Fatty acid metabolism_Homo sapiens_hsa012120.60128125
52Arginine and proline metabolism_Homo sapiens_hsa003300.59196222
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.58904970
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54439275
55Lysine degradation_Homo sapiens_hsa003100.53614265
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53199051
57Herpes simplex infection_Homo sapiens_hsa051680.50705370
58PPAR signaling pathway_Homo sapiens_hsa033200.50553243
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.49719249
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49511822
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49015979
62Renin secretion_Homo sapiens_hsa049240.48276056
63Chemokine signaling pathway_Homo sapiens_hsa040620.48067323
64Toxoplasmosis_Homo sapiens_hsa051450.47404787
65Measles_Homo sapiens_hsa051620.47188919
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47048008
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.46973167
68Prolactin signaling pathway_Homo sapiens_hsa049170.46523119
69Leishmaniasis_Homo sapiens_hsa051400.44938622
70Platelet activation_Homo sapiens_hsa046110.44926964
71Renin-angiotensin system_Homo sapiens_hsa046140.44192704
72Viral carcinogenesis_Homo sapiens_hsa052030.43712576
73Tyrosine metabolism_Homo sapiens_hsa003500.43361547
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43282374
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42752798
76Osteoclast differentiation_Homo sapiens_hsa043800.42623299
77Cholinergic synapse_Homo sapiens_hsa047250.41928046
78VEGF signaling pathway_Homo sapiens_hsa043700.41750811
79Oocyte meiosis_Homo sapiens_hsa041140.40237114
80Selenocompound metabolism_Homo sapiens_hsa004500.40057297
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.38386853
82Regulation of autophagy_Homo sapiens_hsa041400.38107973
83Fat digestion and absorption_Homo sapiens_hsa049750.37512699
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.37182820
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36011331
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34875071
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.34095630
88Glutamatergic synapse_Homo sapiens_hsa047240.33666154
89ECM-receptor interaction_Homo sapiens_hsa045120.32949758
90Adherens junction_Homo sapiens_hsa045200.31055606
91Thyroid hormone synthesis_Homo sapiens_hsa049180.30925625
92Retinol metabolism_Homo sapiens_hsa008300.30637423
93Gastric acid secretion_Homo sapiens_hsa049710.30284441
94Nitrogen metabolism_Homo sapiens_hsa009100.29727035
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29049295
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28586758
97Fanconi anemia pathway_Homo sapiens_hsa034600.28177426
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27943504
99African trypanosomiasis_Homo sapiens_hsa051430.27597428
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26730671

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