OLFML2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an olfactomedin domain-containing protein. Most olfactomedin domain-containing proteins are secreted glycoproteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.80201997
2collagen fibril organization (GO:0030199)6.27811434
3regulation of mononuclear cell migration (GO:0071675)5.48893278
4barbed-end actin filament capping (GO:0051016)5.22711445
5skin morphogenesis (GO:0043589)5.01359036
6extracellular fibril organization (GO:0043206)4.77506666
7virion attachment to host cell (GO:0019062)4.76979746
8adhesion of symbiont to host cell (GO:0044650)4.76979746
9chondrocyte proliferation (GO:0035988)4.67821241
10bone trabecula formation (GO:0060346)4.54551013
11cardiac myofibril assembly (GO:0055003)4.51860377
12plasma membrane repair (GO:0001778)4.49668313
13sequestering of extracellular ligand from receptor (GO:0035581)4.49044868
14endodermal cell differentiation (GO:0035987)4.45762473
15adhesion of symbiont to host (GO:0044406)4.38496014
16regulation of macrophage chemotaxis (GO:0010758)4.27296943
17cellular response to thyroid hormone stimulus (GO:0097067)4.26433467
18collagen metabolic process (GO:0032963)4.24409148
19collagen catabolic process (GO:0030574)4.17732570
20fibril organization (GO:0097435)4.17639569
21multicellular organismal macromolecule metabolic process (GO:0044259)3.99569933
22negative regulation of interleukin-12 production (GO:0032695)3.98396183
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.97409724
24gonadal mesoderm development (GO:0007506)3.86836145
25multicellular organismal catabolic process (GO:0044243)3.82051862
26glycosphingolipid catabolic process (GO:0046479)3.81317702
27neuron projection extension involved in neuron projection guidance (GO:1902284)3.78338032
28axon extension involved in axon guidance (GO:0048846)3.78338032
29multicellular organismal metabolic process (GO:0044236)3.74645041
30basement membrane organization (GO:0071711)3.71600983
31negative regulation of fatty acid transport (GO:2000192)3.69515804
32epithelial cell-cell adhesion (GO:0090136)3.69290318
33extracellular matrix assembly (GO:0085029)3.63602708
34myofibril assembly (GO:0030239)3.57824201
35amino sugar catabolic process (GO:0046348)3.55761163
36extracellular matrix disassembly (GO:0022617)3.51619477
37positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.47796276
38dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.43932643
39response to peptidoglycan (GO:0032494)3.42385633
40cellular response to cadmium ion (GO:0071276)3.40331513
41metanephric mesenchyme development (GO:0072075)3.38948265
42glycolipid catabolic process (GO:0019377)3.38440516
43sarcomere organization (GO:0045214)3.36641777
44negative regulation of nitric oxide biosynthetic process (GO:0045019)3.35391945
45dermatan sulfate biosynthetic process (GO:0030208)3.34181463
46actin-myosin filament sliding (GO:0033275)3.33868410
47muscle filament sliding (GO:0030049)3.33868410
48cell adhesion mediated by integrin (GO:0033627)3.33789318
49cellular response to zinc ion (GO:0071294)3.30194067
50glomerular basement membrane development (GO:0032836)3.30139224
51keratan sulfate catabolic process (GO:0042340)3.29493369
52cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.25487207
53trabecula formation (GO:0060343)3.25313698
54response to thyroid hormone (GO:0097066)3.24657596
55retina vasculature morphogenesis in camera-type eye (GO:0061299)3.24466764
56oligosaccharide catabolic process (GO:0009313)3.23719737
57stress fiber assembly (GO:0043149)3.20999310
58endothelial cell chemotaxis (GO:0035767)3.19772246
59detection of molecule of bacterial origin (GO:0032490)3.19383524
60vascular endothelial growth factor signaling pathway (GO:0038084)3.14773457
61eosinophil chemotaxis (GO:0048245)3.12451438
62protein localization to endosome (GO:0036010)3.09123469
63regulation of vitamin D biosynthetic process (GO:0060556)3.09006745
64positive regulation of endothelial cell apoptotic process (GO:2000353)3.08331990
65peripheral nervous system axon ensheathment (GO:0032292)3.05103572
66myelination in peripheral nervous system (GO:0022011)3.05103572
67kidney mesenchyme development (GO:0072074)3.04431350
68negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.03469861
69regulation of membrane protein ectodomain proteolysis (GO:0051043)3.02954787
70actin-mediated cell contraction (GO:0070252)3.00736126
71positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.00654057
72dermatan sulfate metabolic process (GO:0030205)3.00152869
73mesenchymal-epithelial cell signaling (GO:0060638)2.99695780
74insulin-like growth factor receptor signaling pathway (GO:0048009)2.97381658
75endocardial cushion development (GO:0003197)2.94791071
76ceramide catabolic process (GO:0046514)2.94234155
77lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93943699
78actomyosin structure organization (GO:0031032)2.93163633
79* extracellular matrix organization (GO:0030198)2.92275537
80positive regulation of chemokine biosynthetic process (GO:0045080)2.92007184
81positive regulation of receptor recycling (GO:0001921)2.91911126
82N-acetylneuraminate metabolic process (GO:0006054)2.91652924
83venous blood vessel morphogenesis (GO:0048845)2.91573624
84* extracellular structure organization (GO:0043062)2.91299203
85glial cell migration (GO:0008347)2.90286861
86negative regulation of chondrocyte differentiation (GO:0032331)2.89529112
87muscle cell fate commitment (GO:0042693)2.87967782
88heart trabecula formation (GO:0060347)2.87004343
89peptidyl-proline hydroxylation (GO:0019511)2.86082166
90macrophage differentiation (GO:0030225)2.85002251
91peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.84872403
92positive regulation of cellular amide metabolic process (GO:0034250)2.81655705
93pinocytosis (GO:0006907)2.81071827
94wound healing, spreading of epidermal cells (GO:0035313)2.80850342
95regulation of podosome assembly (GO:0071801)2.80831944
96apoptotic cell clearance (GO:0043277)2.80828450
97monocyte chemotaxis (GO:0002548)2.80619003
98macrophage activation involved in immune response (GO:0002281)2.79912585
99negative regulation of nitric-oxide synthase activity (GO:0051001)2.78193226
100eosinophil migration (GO:0072677)2.76045465
101myoblast fusion (GO:0007520)2.75953878
102positive regulation of monocyte chemotaxis (GO:0090026)2.75340618
103tooth mineralization (GO:0034505)2.74965971
104membrane lipid catabolic process (GO:0046466)2.74616506
105endothelial cell morphogenesis (GO:0001886)2.74615878
106negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.74254741
107atrioventricular valve morphogenesis (GO:0003181)2.73612921
108decidualization (GO:0046697)2.73119476
109regulation of cholesterol storage (GO:0010885)2.72802858
110atrial septum morphogenesis (GO:0060413)2.71930537
111regulation of monocyte chemotaxis (GO:0090025)2.71919317
112regulation of tight junction assembly (GO:2000810)2.71194150
113cell-matrix adhesion (GO:0007160)2.71130407
114neutrophil activation involved in immune response (GO:0002283)2.71041342
115positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.70475937
116positive regulation of fibroblast migration (GO:0010763)2.70160556
117craniofacial suture morphogenesis (GO:0097094)2.68472421
118cell migration involved in heart development (GO:0060973)2.67144333
119substrate-dependent cell migration (GO:0006929)2.67037175
120cellular response to vitamin (GO:0071295)2.66758516
121regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.66614019
122negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.65942433
123negative regulation of erythrocyte differentiation (GO:0045647)2.65565223
124protein hydroxylation (GO:0018126)2.65181627
125establishment of nucleus localization (GO:0040023)2.65043126
126syncytium formation by plasma membrane fusion (GO:0000768)2.64879101
127actin filament-based movement (GO:0030048)2.63778172
128peptide catabolic process (GO:0043171)2.63510743
129chondrocyte development (GO:0002063)2.63363117
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.62493936
131positive regulation of heat generation (GO:0031652)2.61972237
132positive regulation of cholesterol efflux (GO:0010875)2.61407420
133syncytium formation (GO:0006949)2.61164738
134adenosine receptor signaling pathway (GO:0001973)2.60115963
135regulation of early endosome to late endosome transport (GO:2000641)2.59874136
136T-helper 1 type immune response (GO:0042088)2.59665682
137positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.58034641
138glomerular filtration (GO:0003094)2.57738919
139cellular response to amino acid stimulus (GO:0071230)2.57427871
140protein targeting to plasma membrane (GO:0072661)2.55358708
141endochondral ossification (GO:0001958)2.54621565
142replacement ossification (GO:0036075)2.54621565
143positive regulation of epithelial to mesenchymal transition (GO:0010718)2.53909952
144positive regulation of osteoblast proliferation (GO:0033690)2.53327628
145substrate adhesion-dependent cell spreading (GO:0034446)2.51934450
146sphingolipid catabolic process (GO:0030149)2.51700091
147chondroitin sulfate catabolic process (GO:0030207)2.51621325
148organ induction (GO:0001759)2.51590143
149cell-substrate adhesion (GO:0031589)2.50771357
150negative regulation of cartilage development (GO:0061037)2.50596932
151cardiac muscle cell development (GO:0055013)2.50381074
152positive regulation of fat cell differentiation (GO:0045600)2.49942067
153cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.48873812
154regulation of fever generation (GO:0031620)2.48052051
155positive regulation of leukocyte degranulation (GO:0043302)2.47592531
156negative regulation of heart growth (GO:0061117)2.47262038
157negative regulation of cardiac muscle tissue growth (GO:0055022)2.47262038
158regulation of cardiac muscle cell apoptotic process (GO:0010665)2.45893936
159negative regulation of potassium ion transmembrane transport (GO:1901380)2.44663512
160protein localization to cell surface (GO:0034394)2.44531731
161mannose metabolic process (GO:0006013)2.44421617
162positive regulation of extracellular matrix organization (GO:1903055)2.43326426
163positive regulation of smooth muscle cell migration (GO:0014911)2.42602191
164phagocytosis, engulfment (GO:0006911)2.41188552
165immunoglobulin mediated immune response (GO:0016064)2.40255959
166negative regulation of cytokine production involved in immune response (GO:0002719)2.39194574
167regulation of chemokine biosynthetic process (GO:0045073)2.39126439
168low-density lipoprotein particle clearance (GO:0034383)2.38854211
169phagocytosis, recognition (GO:0006910)2.38611294
170cortical actin cytoskeleton organization (GO:0030866)2.37890800
171negative regulation of monooxygenase activity (GO:0032769)2.37109191
172positive regulation by symbiont of host defense response (GO:0052509)2.37040531
173modulation by symbiont of host defense response (GO:0052031)2.37040531
174modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.37040531
175modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.37040531
176positive regulation by organism of defense response of other organism involved in symbiotic interact2.37040531
177modulation by symbiont of host immune response (GO:0052553)2.37040531
178negative regulation of smooth muscle cell migration (GO:0014912)2.36031811
179regulation of vitamin metabolic process (GO:0030656)2.35358616
180glycosaminoglycan catabolic process (GO:0006027)2.35190450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.46409123
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.68392099
3* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.58874066
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.54886934
5* EP300_21415370_ChIP-Seq_HL-1_Mouse2.90301934
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.81451864
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.70456837
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.67210806
9CLOCK_20551151_ChIP-Seq_293T_Human2.66727128
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.64781699
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.60577771
12* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.54532776
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52881141
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.49823552
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.43456887
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.41769164
17* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.39104662
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29788604
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.29433954
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.24772169
21* CJUN_26792858_Chip-Seq_BT549_Human2.24708024
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23408190
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.21038274
24EZH2_22144423_ChIP-Seq_EOC_Human2.19693323
25STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13554973
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.10242170
27CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10106554
28CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.05203340
29VDR_24787735_ChIP-Seq_THP-1_Human2.01608359
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99745300
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99745300
32* LXR_22292898_ChIP-Seq_THP-1_Human1.91305481
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.85650399
34BRD4_25478319_ChIP-Seq_HGPS_Human1.84695553
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83603624
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.82491454
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.82491454
38* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.75957662
39* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75421421
40TP53_16413492_ChIP-PET_HCT116_Human1.74013813
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72810880
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70352910
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70070748
44VDR_24763502_ChIP-Seq_THP-1_Human1.70063398
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66870643
46* TBX20_22080862_ChIP-Seq_HEART_Mouse1.61933084
47* TBX20_22328084_ChIP-Seq_HEART_Mouse1.61933084
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61028370
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.58117407
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.57588011
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.56926719
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56217748
53DROSHA_22980978_ChIP-Seq_HELA_Human1.53268687
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53012860
55TP53_18474530_ChIP-ChIP_U2OS_Human1.49819558
56* SPI1_23127762_ChIP-Seq_K562_Human1.47977569
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.47436418
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46641248
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.43964221
60* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.43431404
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42177232
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40933294
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.40750696
64VDR_21846776_ChIP-Seq_THP-1_Human1.38799553
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36646389
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.35873037
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35741876
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35337715
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33956993
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33454862
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32820869
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32812718
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.31794338
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31665811
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30547128
76SMC1_22415368_ChIP-Seq_MEFs_Mouse1.29300616
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.29198055
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28995826
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28955317
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28552066
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27982755
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27902800
83ISL1_27105846_Chip-Seq_CPCs_Mouse1.24657589
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.24146354
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20136135
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.19776873
87* KDM2B_26808549_Chip-Seq_K562_Human1.18947250
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18784244
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18230852
90STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18228772
91SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16360339
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16360339
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16041386
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15769617
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14869829
96* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14728489
97GBX2_23144817_ChIP-Seq_PC3_Human1.14365218
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13890083
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13167864
100JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13046543
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11570125
102TP53_23651856_ChIP-Seq_MEFs_Mouse1.11050535
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09840949
104EZH2_27294783_Chip-Seq_ESCs_Mouse1.09440365
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07020187
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06153471
107SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06094992
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06087084
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05716341
110SA1_22415368_ChIP-Seq_MEFs_Mouse1.05329081
111* PU_27001747_Chip-Seq_BMDM_Mouse1.04612169
112IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04530358
113ERG_21242973_ChIP-ChIP_JURKAT_Human1.04326988
114IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03162000
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03058210
116* UBF1/2_26484160_Chip-Seq_HMECs_Human1.02672810
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02470555
118DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02188183
119RACK7_27058665_Chip-Seq_MCF-7_Human1.02057285
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01848416
121EGR1_19374776_ChIP-ChIP_THP-1_Human1.01457779
122ZNF274_21170338_ChIP-Seq_K562_Hela1.00735815
123FOXO3_23340844_ChIP-Seq_DLD1_Human1.00538108
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99803739
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99781293
126PIAS1_25552417_ChIP-Seq_VCAP_Human0.99345260
127TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99303447
128MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99133987
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98996229
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98942070
131SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98163165
132TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97372242
133CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97018734
134PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96715128
135* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95516680
136* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94731394
137STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94286363
138ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94237346
139RING1B_27294783_Chip-Seq_ESCs_Mouse0.94083718
140SOX2_20726797_ChIP-Seq_SW620_Human0.93877012
141GATA1_19941827_ChIP-Seq_MEL_Mouse0.93842104
142STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93742052
143TCF7_22412390_ChIP-Seq_EML_Mouse0.93423595
144KDM2B_26808549_Chip-Seq_DND41_Human0.93283797
145SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93113430
146PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92971070
147THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92533061
148GATA1_19941826_ChIP-Seq_K562_Human0.92292893
149LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89749240
150RUNX1_22412390_ChIP-Seq_EML_Mouse0.87578643
151NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87012321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.91290329
2MP0005503_abnormal_tendon_morphology5.28161719
3MP0005275_abnormal_skin_tensile5.11982124
4MP0005058_abnormal_lysosome_morphology4.40122993
5MP0003279_aneurysm3.48370225
6MP0000751_myopathy3.17816765
7MP0003705_abnormal_hypodermis_morpholog3.02828563
8MP0009840_abnormal_foam_cell2.94391808
9MP0004272_abnormal_basement_membrane2.91965899
10MP0005623_abnormal_meninges_morphology2.82569715
11MP0001958_emphysema2.80947651
12MP0003303_peritoneal_inflammation2.62255577
13MP0006082_CNS_inflammation2.60420645
14MP0003436_decreased_susceptibility_to2.33562300
15MP0002837_dystrophic_cardiac_calcinosis2.26872983
16MP0003172_abnormal_lysosome_physiology2.24835681
17MP0009384_cardiac_valve_regurgitation2.22891492
18MP0000604_amyloidosis2.21940223
19MP0002108_abnormal_muscle_morphology2.18437723
20MP0004084_abnormal_cardiac_muscle2.16439570
21MP0003300_gastrointestinal_ulcer2.06794078
22MP0006054_spinal_hemorrhage2.06115809
23MP0001533_abnormal_skeleton_physiology2.03663549
24MP0000749_muscle_degeneration2.02562687
25MP0002148_abnormal_hypersensitivity_rea2.02339410
26MP0003566_abnormal_cell_adhesion2.01635035
27MP0005257_abnormal_intraocular_pressure1.96852908
28MP0005508_abnormal_skeleton_morphology1.91379242
29MP0003075_altered_response_to1.91309957
30MP0005167_abnormal_blood-brain_barrier1.90006184
31MP0000750_abnormal_muscle_regeneration1.89860614
32MP0002419_abnormal_innate_immunity1.80470954
33MP0000733_abnormal_muscle_development1.78453454
34MP0003191_abnormal_cellular_cholesterol1.77210087
35MP0001542_abnormal_bone_strength1.75118226
36MP0009785_altered_susceptibility_to1.74601716
37MP0002060_abnormal_skin_morphology1.68522050
38MP0003448_altered_tumor_morphology1.64031041
39MP0004087_abnormal_muscle_fiber1.60703247
40MP0003091_abnormal_cell_migration1.57210519
41MP0000767_abnormal_smooth_muscle1.54126611
42MP0002295_abnormal_pulmonary_circulatio1.53162563
43MP0009250_abnormal_appendicular_skeleto1.43419120
44MP0003724_increased_susceptibility_to1.42809584
45MP0005023_abnormal_wound_healing1.41080276
46MP0000013_abnormal_adipose_tissue1.40844000
47MP0003385_abnormal_body_wall1.39267086
48MP0005330_cardiomyopathy1.38458505
49MP0006138_congestive_heart_failure1.38427614
50MP0010030_abnormal_orbit_morphology1.38241820
51MP0004145_abnormal_muscle_electrophysio1.38190883
52MP0004036_abnormal_muscle_relaxation1.38098374
53MP0002896_abnormal_bone_mineralization1.37071652
54MP0001299_abnormal_eye_distance/1.36144480
55MP0003690_abnormal_glial_cell1.35658116
56MP0005369_muscle_phenotype1.35020385
57MP0003329_amyloid_beta_deposits1.34643981
58MP0000759_abnormal_skeletal_muscle1.33841597
59MP0001853_heart_inflammation1.32997423
60MP0005000_abnormal_immune_tolerance1.30814387
61MP0010368_abnormal_lymphatic_system1.30813732
62MP0002254_reproductive_system_inflammat1.30432130
63MP0001790_abnormal_immune_system1.29686197
64MP0005387_immune_system_phenotype1.29686197
65MP0009764_decreased_sensitivity_to1.28671610
66MP0004215_abnormal_myocardial_fiber1.26833867
67MP0002972_abnormal_cardiac_muscle1.25084629
68MP0003453_abnormal_keratinocyte_physiol1.24914753
69MP0001849_ear_inflammation1.24530997
70MP0003795_abnormal_bone_structure1.24321418
71MP0003045_fibrosis1.24279783
72MP0000747_muscle_weakness1.23915331
73MP0000858_altered_metastatic_potential1.23260973
74MP0002106_abnormal_muscle_physiology1.22845369
75MP0005025_abnormal_response_to1.21682326
76MP0005620_abnormal_muscle_contractility1.20063315
77MP0005164_abnormal_response_to1.19551534
78MP0003115_abnormal_respiratory_system1.17757210
79MP0000920_abnormal_myelination1.14202666
80MP0000685_abnormal_immune_system1.13396500
81MP0010630_abnormal_cardiac_muscle1.11455089
82MP0008775_abnormal_heart_ventricle1.10954872
83MP0004233_abnormal_muscle_weight1.09551431
84MP0001243_abnormal_dermal_layer1.08938153
85MP0004883_abnormal_blood_vessel1.08175598
86MP0002139_abnormal_hepatobiliary_system1.06961507
87MP0003950_abnormal_plasma_membrane1.05177698
88MP0001835_abnormal_antigen_presentation1.03586029
89MP0002234_abnormal_pharynx_morphology1.03503933
90MP0005390_skeleton_phenotype1.03316213
91MP0003283_abnormal_digestive_organ1.03010057
92MP0003828_pulmonary_edema1.02870231
93MP0001545_abnormal_hematopoietic_system1.01995205
94MP0005397_hematopoietic_system_phenotyp1.01995205
95MP0000534_abnormal_ureter_morphology1.01291801
96MP0002933_joint_inflammation1.01090641
97MP0004134_abnormal_chest_morphology1.00998950
98MP0002452_abnormal_antigen_presenting1.00693398
99MP0000428_abnormal_craniofacial_morphol1.00572031
100MP0001544_abnormal_cardiovascular_syste1.00224467
101MP0005385_cardiovascular_system_phenoty1.00224467
102MP0008260_abnormal_autophagy1.00074575
103MP0003634_abnormal_glial_cell0.99776871
104MP0002877_abnormal_melanocyte_morpholog0.99598685
105MP0002128_abnormal_blood_circulation0.98652649
106MP0002269_muscular_atrophy0.98242853
107MP0005165_increased_susceptibility_to0.97533317
108MP0010352_gastrointestinal_tract_polyps0.96740019
109MP0000163_abnormal_cartilage_morphology0.96598049
110MP0002282_abnormal_trachea_morphology0.96142175
111MP0008469_abnormal_protein_level0.95992901
112MP0004185_abnormal_adipocyte_glucose0.94151403
113MP0002115_abnormal_skeleton_extremities0.94101071
114MP0002932_abnormal_joint_morphology0.93049671
115MP0005595_abnormal_vascular_smooth0.90597402
116MP0001845_abnormal_inflammatory_respons0.89570082
117MP0003122_maternal_imprinting0.88915965
118MP0005671_abnormal_response_to0.88897245
119MP0000003_abnormal_adipose_tissue0.88883844
120MP0002168_other_aberrant_phenotype0.86861728
121MP0003942_abnormal_urinary_system0.85424939
122MP0004484_altered_response_of0.85379443
123MP0009780_abnormal_chondrocyte_physiolo0.85174655
124MP0008004_abnormal_stomach_pH0.85085095
125MP0005171_absent_coat_pigmentation0.85049892
126MP0001879_abnormal_lymphatic_vessel0.84430232
127MP0005166_decreased_susceptibility_to0.83693527
128MP0002405_respiratory_system_inflammati0.82593856
129MP0000249_abnormal_blood_vessel0.81931235
130MP0002998_abnormal_bone_remodeling0.80083485
131MP0002113_abnormal_skeleton_development0.79858040
132MP0001614_abnormal_blood_vessel0.79791563
133MP0005310_abnormal_salivary_gland0.79672650
134MP0002089_abnormal_postnatal_growth/wei0.79527177
135MP0002723_abnormal_immune_serum0.78823481
136MP0003935_abnormal_craniofacial_develop0.78411347
137MP0002925_abnormal_cardiovascular_devel0.78244864
138MP0005076_abnormal_cell_differentiation0.76457773
139MP0005388_respiratory_system_phenotype0.76316892
140MP0002133_abnormal_respiratory_system0.76316892
141MP0004947_skin_inflammation0.75739751
142MP0000266_abnormal_heart_morphology0.75066731
143MP0004510_myositis0.72899471
144MP0003755_abnormal_palate_morphology0.71823124
145MP0003137_abnormal_impulse_conducting0.71133525
146MP0000343_altered_response_to0.70286615
147MP0005464_abnormal_platelet_physiology0.69203513
148MP0005375_adipose_tissue_phenotype0.69127204
149MP0004085_abnormal_heartbeat0.67793846
150MP0009053_abnormal_anal_canal0.67402091
151MP0002090_abnormal_vision0.66699233
152MP0005451_abnormal_body_composition0.63303606
153MP0004858_abnormal_nervous_system0.62928729
154MP0009278_abnormal_bone_marrow0.62908949
155MP0000432_abnormal_head_morphology0.62743386
156MP0001819_abnormal_immune_cell0.62288229

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.52896619
2Premature rupture of membranes (HP:0001788)7.24897724
3Abnormality of glycolipid metabolism (HP:0010969)5.99474233
4Abnormality of liposaccharide metabolism (HP:0010968)5.99474233
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.99474233
6Ankle contracture (HP:0006466)5.48001294
7Systemic lupus erythematosus (HP:0002725)4.89173556
8Aortic dissection (HP:0002647)4.84776724
9Type 1 muscle fiber predominance (HP:0003803)4.81073124
10Increased connective tissue (HP:0009025)4.30726046
11Broad metatarsal (HP:0001783)4.26012928
12Soft skin (HP:0000977)4.22591396
13Dysostosis multiplex (HP:0000943)4.20563670
14Atrophic scars (HP:0001075)4.14654837
15Cerebral aneurysm (HP:0004944)4.11942045
16Shallow orbits (HP:0000586)4.00874266
17Spinal rigidity (HP:0003306)3.86925610
18Vacuolated lymphocytes (HP:0001922)3.85017807
19Bladder diverticulum (HP:0000015)3.84401415
20Follicular hyperkeratosis (HP:0007502)3.82351778
21Mildly elevated creatine phosphokinase (HP:0008180)3.70479878
22Abnormality of dentin (HP:0010299)3.69339883
23Aortic aneurysm (HP:0004942)3.66285861
24Fragile skin (HP:0001030)3.62318085
25Peritonitis (HP:0002586)3.61318894
26Dilatation of the ascending aorta (HP:0005111)3.59353685
27Increased variability in muscle fiber diameter (HP:0003557)3.56273766
28Neurofibrillary tangles (HP:0002185)3.55398498
29Increased cerebral lipofuscin (HP:0011813)3.53643105
30Nuclear cataract (HP:0100018)3.46753736
31Slender build (HP:0001533)3.43551437
32Glomerulonephritis (HP:0000099)3.42414026
33Abnormality of mucopolysaccharide metabolism (HP:0011020)3.32190878
34Abnormality of polysaccharide metabolism (HP:0011012)3.32190878
35Abnormality of glycosaminoglycan metabolism (HP:0004371)3.32190878
36Muscle fiber splitting (HP:0003555)3.29479566
37Mitral valve prolapse (HP:0001634)3.27473040
38Mucopolysacchariduria (HP:0008155)3.21924268
39Urinary glycosaminoglycan excretion (HP:0003541)3.21924268
40Abnormality of skeletal muscle fiber size (HP:0012084)3.17265300
41Wormian bones (HP:0002645)3.16014943
42Loss of speech (HP:0002371)3.13210361
43Wrist flexion contracture (HP:0001239)3.10424626
44Genu recurvatum (HP:0002816)3.06340047
45Neonatal short-limb short stature (HP:0008921)3.05068236
46Disinhibition (HP:0000734)3.00681082
47Blue sclerae (HP:0000592)3.00082346
48Mutism (HP:0002300)2.97237273
49Complement deficiency (HP:0004431)2.96331965
50Biconcave vertebral bodies (HP:0004586)2.91962996
51Difficulty climbing stairs (HP:0003551)2.91811887
52Axonal loss (HP:0003447)2.91086850
53Abnormality of macrophages (HP:0004311)2.81223581
54Spontaneous hematomas (HP:0007420)2.78318888
55Cervical subluxation (HP:0003308)2.75846974
56Increased neuronal autofluorescent lipopigment (HP:0002074)2.73469557
57Abnormality of the calf musculature (HP:0001430)2.70043327
58Vertebral compression fractures (HP:0002953)2.65240532
59Hyperextensible skin (HP:0000974)2.64975582
60Distal lower limb amyotrophy (HP:0008944)2.63688380
61Overgrowth (HP:0001548)2.55395098
62Abnormality of the vasculature of the conjunctiva (HP:0008054)2.55136224
63Cerebral inclusion bodies (HP:0100314)2.54260745
64Round ear (HP:0100830)2.50115242
65Abnormality of complement system (HP:0005339)2.49698212
66Asymmetric septal hypertrophy (HP:0001670)2.47958665
67Infantile muscular hypotonia (HP:0008947)2.46262018
68Joint stiffness (HP:0001387)2.44257857
69Bowel diverticulosis (HP:0005222)2.43047199
70Hyporeflexia of lower limbs (HP:0002600)2.40448431
71Aneurysm (HP:0002617)2.39863735
72Hematochezia (HP:0002573)2.38966137
73Osteolytic defects of the hand bones (HP:0009699)2.38416683
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.38416683
75Vascular tortuosity (HP:0004948)2.36224706
76Abnormal delivery (HP:0001787)2.34844869
77Striae distensae (HP:0001065)2.34523282
78Right ventricular cardiomyopathy (HP:0011663)2.32740806
79Scapular winging (HP:0003691)2.31875857
80Sudden death (HP:0001699)2.31265523
81Joint laxity (HP:0001388)2.30328298
82Limb-girdle muscle weakness (HP:0003325)2.26087614
83Elbow flexion contracture (HP:0002987)2.25669117
84Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.24988448
85Arterial tortuosity (HP:0005116)2.18214160
86Recurrent abscess formation (HP:0002722)2.17866404
87Absent frontal sinuses (HP:0002688)2.17783176
88Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.17593594
89Amyloidosis (HP:0011034)2.15485621
90Lower limb amyotrophy (HP:0007210)2.15390206
91Venous abnormality (HP:0002624)2.15276854
92Recurrent bacterial skin infections (HP:0005406)2.14621413
93Thin bony cortex (HP:0002753)2.13006327
94Lipoatrophy (HP:0100578)2.12638121
95Broad ribs (HP:0000885)2.12332839
96Mitral regurgitation (HP:0001653)2.11888397
97Difficulty running (HP:0009046)2.08368621
98Venous insufficiency (HP:0005293)2.06635558
99Wide anterior fontanel (HP:0000260)2.06181481
100Generalized amyotrophy (HP:0003700)2.05910077
101Deviation of the hallux (HP:0010051)2.05391803
102Ulnar deviation of the wrist (HP:0003049)2.05054241
103Increased density of long bones (HP:0006392)2.04194878
104Ovoid vertebral bodies (HP:0003300)2.03749601
105Metaphyseal irregularity (HP:0003025)2.02947897
106EMG: myopathic abnormalities (HP:0003458)2.02858252
107Eczematoid dermatitis (HP:0000976)2.01763775
108Distal upper limb amyotrophy (HP:0007149)2.00363052
109Upper limb amyotrophy (HP:0009129)2.00363052
110Camptodactyly of toe (HP:0001836)2.00112016
111Spondylolisthesis (HP:0003302)1.98658716
112Muscle fiber inclusion bodies (HP:0100299)1.98136192
113Buphthalmos (HP:0000557)1.97360635
114Myocardial infarction (HP:0001658)1.97081972
115Aortic regurgitation (HP:0001659)1.96025091
116Hallux valgus (HP:0001822)1.95752364
117Hip contracture (HP:0003273)1.94058120
118Hypoventilation (HP:0002791)1.93349438
119Abnormality of the acetabulum (HP:0003170)1.93338587
120Atrial fibrillation (HP:0005110)1.93274027
121Retinal atrophy (HP:0001105)1.91890531
122Apathy (HP:0000741)1.91734488
123Osteoarthritis (HP:0002758)1.91375828
124Thin ribs (HP:0000883)1.91297818
125Mesomelia (HP:0003027)1.91030621
126Calf muscle hypertrophy (HP:0008981)1.90603349
127Nephritis (HP:0000123)1.87202551
128Mild short stature (HP:0003502)1.87128220
129Tibial bowing (HP:0002982)1.86918778
130Diminished motivation (HP:0000745)1.86546518
131Upper motor neuron abnormality (HP:0002127)1.86018336
132Knee flexion contracture (HP:0006380)1.85445699
133Recurrent gram-negative bacterial infections (HP:0005420)1.85415210
134Pathologic fracture (HP:0002756)1.85341025
135Bell-shaped thorax (HP:0001591)1.84712686
136Short nail (HP:0001799)1.83049728
137Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.82839250
138Primary atrial arrhythmia (HP:0001692)1.81723094
139Flat cornea (HP:0007720)1.81184520
140Breech presentation (HP:0001623)1.79420787
141Nonimmune hydrops fetalis (HP:0001790)1.78730041
142Alopecia of scalp (HP:0002293)1.77825521
143Purpura (HP:0000979)1.77391318
144Pulmonary artery stenosis (HP:0004415)1.77123950
145Femoral bowing (HP:0002980)1.76339223
146Inguinal hernia (HP:0000023)1.75866856
147Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75532350
148Short hallux (HP:0010109)1.75414524
149Ulnar bowing (HP:0003031)1.75108215
150Calcaneovalgus deformity (HP:0001848)1.75010388
151Flared iliac wings (HP:0002869)1.74956084
152Supraventricular arrhythmia (HP:0005115)1.74721149
153Spinal cord lesions (HP:0100561)1.74676249
154Abnormality of skull ossification (HP:0002703)1.71054060
155Conjunctival telangiectasia (HP:0000524)1.69890203
156Bone pain (HP:0002653)1.68297474
157Cupped ribs (HP:0000887)1.67867985
158Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67832503

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.78568320
2TRIB34.01561984
3DDR23.83094810
4PDGFRA3.54811496
5BLK3.32251144
6PKN22.80341983
7IRAK32.78789263
8MYLK2.76633741
9DMPK2.57978175
10RIPK12.28239780
11FER2.15249890
12PTK2B2.10220340
13NME22.02632985
14LATS12.02133260
15GRK71.96758786
16LATS21.95840124
17MAP3K141.88258193
18TYK21.77094940
19OBSCN1.76350447
20TBK11.75721738
21PAK21.75201164
22TAOK21.67614869
23ERN11.67454300
24TRPM71.64512694
25PAK31.63926251
26MAP3K131.62696779
27CSK1.61010567
28EPHB11.59254944
29EPHB21.56734150
30NTRK31.52895905
31MOS1.52349597
32TGFBR21.51036397
33MAP3K31.48098715
34PDGFRB1.44071496
35EPHA31.44042485
36MATK1.43917402
37CSF1R1.43832055
38SIK11.42879653
39ILK1.42607977
40BMX1.37130494
41FGFR41.33840489
42ROCK11.31863603
43PTK21.31506404
44PRKD31.30862069
45PAK41.29925818
46LIMK11.29517757
47KIT1.26963725
48PIK3CA1.17329744
49ROCK21.16756547
50FGFR11.16018609
51PTK61.13034272
52TGFBR11.10289364
53MUSK1.09567597
54MAP3K61.08577144
55LMTK21.05059588
56MAP3K111.03259943
57MAP2K31.02497904
58TAOK11.01260879
59CDC42BPA0.98220133
60TNIK0.97720021
61ZAP700.96873877
62PIK3CG0.96059148
63PLK20.95829140
64MET0.95078978
65EPHA40.94499130
66STK30.93926119
67RET0.93921533
68ARAF0.92291306
69PIM20.91310281
70TESK10.91159755
71MAP2K10.89994515
72DAPK30.85641871
73MAP3K100.83054775
74MAPK70.82683062
75NTRK10.80753712
76PAK60.79591244
77MTOR0.79250350
78TYRO30.78228618
79JAK30.77171927
80IKBKB0.76978492
81PRKCH0.75670939
82CAMK1D0.74929460
83STK240.74511735
84STK38L0.72529177
85PRKD10.72500426
86PDK40.72410871
87PDK30.72410871
88LRRK20.71546343
89ICK0.69923914
90PDK20.66367775
91FGFR20.65672067
92CAMKK20.65135664
93FES0.64402373
94ADRBK20.62468494
95MARK20.61922348
96CAMKK10.61391528
97CAMK2D0.60684142
98IKBKE0.59830586
99RPS6KC10.59311781
100RPS6KL10.59311781
101LYN0.58910313
102IRAK40.58646349
103KSR20.57931857
104RIPK40.55920348
105MAPKAPK30.54591210
106MAP3K10.54228840
107PHKG10.54172194
108PHKG20.54172194
109INSR0.54143838
110ERBB30.53554943
111SIK20.53527534
112CAMK1G0.52372027
113NEK90.52278130
114CDK150.51514830
115ABL10.50802755
116PRKD20.50591619
117MAPK40.50590830
118PRKG20.50588051
119CDK140.49570727
120PRPF4B0.49455114
121CDK180.49443036
122EEF2K0.47188786
123ACVR1B0.47017085
124MAP3K70.45015560
125CHUK0.43571661
126WNK10.42637902
127SRC0.42470850
128PRKCE0.41974316
129RPS6KA20.40954967
130FRK0.40947521
131RPS6KA60.40266850
132TIE10.40167594
133ABL20.40098901
134FGFR30.39789289
135CAMK2A0.38178178
136CDK11A0.38025304
137JAK20.36901522
138PDPK10.36791882
139CAMK2G0.36082431
140CLK10.35965940
141KSR10.35857811
142GSK3A0.35628163
143MAP3K40.34862533
144PAK10.32104576
145ADRBK10.31620151
146MAPK120.30809693
147JAK10.30584371
148CDK60.30118754
149CDK120.28417415
150FGR0.27493458

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.15020983
2Other glycan degradation_Homo sapiens_hsa005114.11596647
3Lysosome_Homo sapiens_hsa041423.35750980
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.14340058
5Dilated cardiomyopathy_Homo sapiens_hsa054143.14108607
6Focal adhesion_Homo sapiens_hsa045103.06008218
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.99261862
8Staphylococcus aureus infection_Homo sapiens_hsa051502.98091360
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.66654584
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.59720253
11Rheumatoid arthritis_Homo sapiens_hsa053232.36144369
12Osteoclast differentiation_Homo sapiens_hsa043802.33299696
13Protein digestion and absorption_Homo sapiens_hsa049742.20328789
14Amoebiasis_Homo sapiens_hsa051462.09932286
15Pertussis_Homo sapiens_hsa051332.08349085
16Proteoglycans in cancer_Homo sapiens_hsa052051.92548747
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90875552
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85183481
19Leishmaniasis_Homo sapiens_hsa051401.84283706
20Prion diseases_Homo sapiens_hsa050201.77495300
21Tuberculosis_Homo sapiens_hsa051521.76377799
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.76216367
23Adherens junction_Homo sapiens_hsa045201.69901499
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68185829
25Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.60996059
26TGF-beta signaling pathway_Homo sapiens_hsa043501.59309694
27Malaria_Homo sapiens_hsa051441.50442018
28Asthma_Homo sapiens_hsa053101.48689779
29Viral myocarditis_Homo sapiens_hsa054161.48027234
30Regulation of actin cytoskeleton_Homo sapiens_hsa048101.42979526
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.38835872
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37362219
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.35504832
34MicroRNAs in cancer_Homo sapiens_hsa052061.34199226
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34183774
36Complement and coagulation cascades_Homo sapiens_hsa046101.33996700
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32711807
38Bladder cancer_Homo sapiens_hsa052191.31409393
39Hippo signaling pathway_Homo sapiens_hsa043901.30715184
40Mineral absorption_Homo sapiens_hsa049781.29930780
41Axon guidance_Homo sapiens_hsa043601.29868466
42Glioma_Homo sapiens_hsa052141.29619124
43Legionellosis_Homo sapiens_hsa051341.29178023
44Allograft rejection_Homo sapiens_hsa053301.27573366
45Small cell lung cancer_Homo sapiens_hsa052221.24517923
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.24192037
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21641490
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.21206057
49Cardiac muscle contraction_Homo sapiens_hsa042601.17761314
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17372129
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15483489
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12611281
53Graft-versus-host disease_Homo sapiens_hsa053321.10622113
54Chronic myeloid leukemia_Homo sapiens_hsa052201.10391295
55Estrogen signaling pathway_Homo sapiens_hsa049151.10083586
56Platelet activation_Homo sapiens_hsa046111.09669464
57Vascular smooth muscle contraction_Homo sapiens_hsa042701.09371863
58Tight junction_Homo sapiens_hsa045301.09013280
59NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08051357
60Melanoma_Homo sapiens_hsa052181.07574669
61Antigen processing and presentation_Homo sapiens_hsa046121.05348455
62Rap1 signaling pathway_Homo sapiens_hsa040151.04614993
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03649095
64Oxytocin signaling pathway_Homo sapiens_hsa049211.02821549
65Gap junction_Homo sapiens_hsa045401.01056350
66Hedgehog signaling pathway_Homo sapiens_hsa043401.00415695
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00116617
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99569273
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.99437880
70Basal cell carcinoma_Homo sapiens_hsa052170.99215041
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.99140522
72Autoimmune thyroid disease_Homo sapiens_hsa053200.97696319
73GnRH signaling pathway_Homo sapiens_hsa049120.95926614
74Dorso-ventral axis formation_Homo sapiens_hsa043200.95907626
75Pancreatic cancer_Homo sapiens_hsa052120.92832202
76Chemokine signaling pathway_Homo sapiens_hsa040620.92386801
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91612799
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91268287
79Melanogenesis_Homo sapiens_hsa049160.91158262
80Wnt signaling pathway_Homo sapiens_hsa043100.87577611
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87006609
82Pathways in cancer_Homo sapiens_hsa052000.85280036
83Hematopoietic cell lineage_Homo sapiens_hsa046400.83782986
84Galactose metabolism_Homo sapiens_hsa000520.83538036
85Vibrio cholerae infection_Homo sapiens_hsa051100.83133194
86HIF-1 signaling pathway_Homo sapiens_hsa040660.82447422
87Toxoplasmosis_Homo sapiens_hsa051450.82055758
88Renal cell carcinoma_Homo sapiens_hsa052110.81109216
89Renin secretion_Homo sapiens_hsa049240.80671113
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.80030534
91cAMP signaling pathway_Homo sapiens_hsa040240.79724171
92Circadian entrainment_Homo sapiens_hsa047130.79096183
93Long-term potentiation_Homo sapiens_hsa047200.77379275
94Collecting duct acid secretion_Homo sapiens_hsa049660.77216883
95Prostate cancer_Homo sapiens_hsa052150.76903248
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76741177
97Insulin resistance_Homo sapiens_hsa049310.76730434
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.76636597
99Influenza A_Homo sapiens_hsa051640.75664844
100VEGF signaling pathway_Homo sapiens_hsa043700.74939766
101Salmonella infection_Homo sapiens_hsa051320.74889788
102B cell receptor signaling pathway_Homo sapiens_hsa046620.73277422
103Shigellosis_Homo sapiens_hsa051310.72537537
104MAPK signaling pathway_Homo sapiens_hsa040100.70807484
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70610957
106Type I diabetes mellitus_Homo sapiens_hsa049400.68848554
107Sphingolipid metabolism_Homo sapiens_hsa006000.68795676
108Calcium signaling pathway_Homo sapiens_hsa040200.68774572
109Colorectal cancer_Homo sapiens_hsa052100.68621813
110Gastric acid secretion_Homo sapiens_hsa049710.68160584
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67803170
112Phagosome_Homo sapiens_hsa041450.67281383
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66833578
114Insulin signaling pathway_Homo sapiens_hsa049100.66517525
115Ras signaling pathway_Homo sapiens_hsa040140.65872760
116Glucagon signaling pathway_Homo sapiens_hsa049220.65543829
117ErbB signaling pathway_Homo sapiens_hsa040120.65235434
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64036001
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63957644
120Thyroid hormone synthesis_Homo sapiens_hsa049180.63692254
121Amphetamine addiction_Homo sapiens_hsa050310.63141905
122mTOR signaling pathway_Homo sapiens_hsa041500.62791418
123Endocytosis_Homo sapiens_hsa041440.62383792
124Type II diabetes mellitus_Homo sapiens_hsa049300.61784550
125Notch signaling pathway_Homo sapiens_hsa043300.61347217
126HTLV-I infection_Homo sapiens_hsa051660.59490186
127Apoptosis_Homo sapiens_hsa042100.59388942
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.59101168
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.58826277
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58335003
131African trypanosomiasis_Homo sapiens_hsa051430.58251404
132Hepatitis C_Homo sapiens_hsa051600.58185658
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58169319
134Hepatitis B_Homo sapiens_hsa051610.57958008
135TNF signaling pathway_Homo sapiens_hsa046680.56651084
136Endometrial cancer_Homo sapiens_hsa052130.56570673
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56102027
138Acute myeloid leukemia_Homo sapiens_hsa052210.55990783
139Salivary secretion_Homo sapiens_hsa049700.55966196
140Ovarian steroidogenesis_Homo sapiens_hsa049130.55526281
141Cholinergic synapse_Homo sapiens_hsa047250.55495961
142PPAR signaling pathway_Homo sapiens_hsa033200.54182435
143Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54167935
144Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54110790
145Dopaminergic synapse_Homo sapiens_hsa047280.53869925
146RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53416254
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53232972
148Cocaine addiction_Homo sapiens_hsa050300.52619165
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49122152
150Jak-STAT signaling pathway_Homo sapiens_hsa046300.43755266
151Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40877943
152Herpes simplex infection_Homo sapiens_hsa051680.39934860
153Prolactin signaling pathway_Homo sapiens_hsa049170.39536457
154Renin-angiotensin system_Homo sapiens_hsa046140.37953387
155Measles_Homo sapiens_hsa051620.37290562
156Fructose and mannose metabolism_Homo sapiens_hsa000510.35508500
157Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33073841

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