OLFML3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the olfactomedin-like gene family which also includes genes encoding noelin, tiarin, myocilin, amassin, optimedin, photomedin, and latrophilin. The encoded protein is a secreted extracellular matrix glycoprotein with a C-terminal olfactomedin domain that facilitates protein-protein interactions, cell adhesion, and intercellular interactions. It serves as both a scaffold protein that recruits bone morphogenetic protein 1 to its substrate chordin, and as a vascular tissue remodeler with pro-angiogenic properties. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)7.32549632
2positive regulation of chemokine secretion (GO:0090197)6.92292180
3barbed-end actin filament capping (GO:0051016)6.30418011
4microglial cell activation (GO:0001774)5.88242668
5protein heterotrimerization (GO:0070208)5.48185629
6collagen fibril organization (GO:0030199)5.45781677
7cell migration involved in heart development (GO:0060973)5.28817718
8chondroitin sulfate catabolic process (GO:0030207)5.28240979
9G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.25610505
10regulation of chemokine secretion (GO:0090196)5.12666036
11extracellular fibril organization (GO:0043206)4.94788520
12macrophage activation involved in immune response (GO:0002281)4.37792320
13regulation of interferon-beta biosynthetic process (GO:0045357)4.35746054
14negative regulation of granulocyte differentiation (GO:0030853)4.32264800
15pathway-restricted SMAD protein phosphorylation (GO:0060389)4.25445291
16fibril organization (GO:0097435)4.25125465
17paraxial mesoderm development (GO:0048339)4.17870537
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.17123644
19kidney mesenchyme development (GO:0072074)4.06795424
20tooth mineralization (GO:0034505)4.04212695
21planar cell polarity pathway involved in neural tube closure (GO:0090179)4.02656996
22heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.98952573
23glial cell migration (GO:0008347)3.98101693
24regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.95713795
25regulation of extracellular matrix disassembly (GO:0010715)3.90828319
26metanephric mesenchyme development (GO:0072075)3.89637485
27peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.88039921
28vascular endothelial growth factor signaling pathway (GO:0038084)3.86634816
29collagen catabolic process (GO:0030574)3.85742244
30peptidyl-proline hydroxylation (GO:0019511)3.85677044
31collagen metabolic process (GO:0032963)3.85154129
32bone trabecula formation (GO:0060346)3.82847223
33endocardial cushion development (GO:0003197)3.79448923
34basement membrane organization (GO:0071711)3.73442906
35negative regulation of androgen receptor signaling pathway (GO:0060766)3.68334865
36regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.66460642
37multicellular organismal macromolecule metabolic process (GO:0044259)3.60205088
38Golgi transport vesicle coating (GO:0048200)3.57555652
39COPI coating of Golgi vesicle (GO:0048205)3.57555652
40hyaluronan catabolic process (GO:0030214)3.56786402
41dermatan sulfate biosynthetic process (GO:0030208)3.55746986
42multicellular organismal catabolic process (GO:0044243)3.53595222
43type B pancreatic cell proliferation (GO:0044342)3.51793423
44dermatan sulfate metabolic process (GO:0030205)3.51783773
45regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.47356314
46regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.46634713
47sequestering of extracellular ligand from receptor (GO:0035581)3.44776013
48oligosaccharide catabolic process (GO:0009313)3.44023682
49macrophage activation (GO:0042116)3.42713810
50regulation of chemokine-mediated signaling pathway (GO:0070099)3.42277731
51endothelial cell morphogenesis (GO:0001886)3.41529755
52lymphangiogenesis (GO:0001946)3.40928630
53outer ear morphogenesis (GO:0042473)3.40086492
54negative regulation of protein localization to plasma membrane (GO:1903077)3.39198301
55G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.37021609
56multicellular organismal metabolic process (GO:0044236)3.36629117
57cell migration involved in sprouting angiogenesis (GO:0002042)3.36076829
58keratan sulfate metabolic process (GO:0042339)3.34789532
59apoptotic cell clearance (GO:0043277)3.34263202
60germ cell migration (GO:0008354)3.33877184
61chondrocyte proliferation (GO:0035988)3.33583609
62virion attachment to host cell (GO:0019062)3.28458650
63adhesion of symbiont to host cell (GO:0044650)3.28458650
64modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.28214927
65positive regulation by organism of defense response of other organism involved in symbiotic interact3.28214927
66modulation by symbiont of host immune response (GO:0052553)3.28214927
67positive regulation by symbiont of host defense response (GO:0052509)3.28214927
68modulation by symbiont of host defense response (GO:0052031)3.28214927
69modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.28214927
70purinergic nucleotide receptor signaling pathway (GO:0035590)3.25394159
71negative regulation of leukocyte chemotaxis (GO:0002689)3.24834004
72cell proliferation involved in kidney development (GO:0072111)3.23733010
73negative regulation of tissue remodeling (GO:0034104)3.22659608
74negative regulation of nitric-oxide synthase activity (GO:0051001)3.21561691
75negative regulation of chondrocyte differentiation (GO:0032331)3.20793781
76protein hydroxylation (GO:0018126)3.18096565
77endodermal cell differentiation (GO:0035987)3.17849222
78skin morphogenesis (GO:0043589)3.17089821
79convergent extension (GO:0060026)3.16288837
80protein localization to cell surface (GO:0034394)3.15067044
81positive regulation of SMAD protein import into nucleus (GO:0060391)3.14966660
82glycosphingolipid catabolic process (GO:0046479)3.11074426
83regulation of SMAD protein import into nucleus (GO:0060390)3.10538988
84negative regulation of osteoblast proliferation (GO:0033689)3.10338018
85maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.08209670
86protein retention in ER lumen (GO:0006621)3.07371278
87cell proliferation involved in metanephros development (GO:0072203)3.07192998
88establishment of apical/basal cell polarity (GO:0035089)3.05192525
89embryonic cranial skeleton morphogenesis (GO:0048701)3.04405225
90regulation of integrin-mediated signaling pathway (GO:2001044)3.03597857
91monocyte differentiation (GO:0030224)3.02964651
92positive regulation of endothelial cell apoptotic process (GO:2000353)3.01923845
93extracellular matrix disassembly (GO:0022617)3.00675660
94glomerular basement membrane development (GO:0032836)2.99718242
95blood vessel maturation (GO:0001955)2.99104395
96G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.97381998
97negative regulation of BMP signaling pathway (GO:0030514)2.97288883
98cochlea morphogenesis (GO:0090103)2.97189428
99I-kappaB phosphorylation (GO:0007252)2.95757259
100positive regulation of catenin import into nucleus (GO:0035413)2.94615738
101proteoglycan biosynthetic process (GO:0030166)2.90356449
102heparan sulfate proteoglycan metabolic process (GO:0030201)2.88011221
103regulation of macrophage chemotaxis (GO:0010758)2.87593514
104Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.87568129
105substrate-dependent cell migration (GO:0006929)2.87296402
106regulation of catenin import into nucleus (GO:0035412)2.85041065
107phagocytosis, engulfment (GO:0006911)2.84886520
108polarized epithelial cell differentiation (GO:0030859)2.84111687
109extracellular matrix assembly (GO:0085029)2.81300145
110muscle cell fate commitment (GO:0042693)2.81181392
111anterior/posterior axis specification, embryo (GO:0008595)2.79222994
112regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78335709
113glycosaminoglycan catabolic process (GO:0006027)2.77991525
114pericardium development (GO:0060039)2.76748914
115neuron projection extension involved in neuron projection guidance (GO:1902284)2.75720794
116axon extension involved in axon guidance (GO:0048846)2.75720794
117adherens junction assembly (GO:0034333)2.75549980
118adhesion of symbiont to host (GO:0044406)2.75548454
119cellular response to interleukin-6 (GO:0071354)2.75152369
120notochord development (GO:0030903)2.75025146
121protein localization to endosome (GO:0036010)2.73751183
122ruffle organization (GO:0031529)2.73238027
123non-canonical Wnt signaling pathway (GO:0035567)2.73019371
124glycolipid catabolic process (GO:0019377)2.72433528
125regulation of macrophage cytokine production (GO:0010935)2.72389018
126glomerular visceral epithelial cell development (GO:0072015)2.72346036
127cellular response to vitamin (GO:0071295)2.71748337
128macrophage differentiation (GO:0030225)2.71087791
129regulation of establishment of planar polarity (GO:0090175)2.70539430
130cyclooxygenase pathway (GO:0019371)2.68429739
131mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.67472457
132hippo signaling (GO:0035329)2.66404310
133substrate adhesion-dependent cell spreading (GO:0034446)2.66001592
134branching involved in salivary gland morphogenesis (GO:0060445)2.64025197
135cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.63851224
136positive regulation of extracellular matrix organization (GO:1903055)2.62154936
137extracellular matrix organization (GO:0030198)2.62134865
138mesenchymal cell differentiation (GO:0048762)2.61966186
139aminoglycan catabolic process (GO:0006026)2.61645613
140cell adhesion mediated by integrin (GO:0033627)2.61502202
141mesenchymal-epithelial cell signaling (GO:0060638)2.61312794
142extracellular structure organization (GO:0043062)2.61022620
143response to cholesterol (GO:0070723)2.60676557
144cortical actin cytoskeleton organization (GO:0030866)2.60280605
145positive regulation of macrophage cytokine production (GO:0060907)2.59805152
146venous blood vessel morphogenesis (GO:0048845)2.58485384
147adenosine receptor signaling pathway (GO:0001973)2.56711853
148positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.56435428
149sulfur compound catabolic process (GO:0044273)2.56177033
150positive regulation of interferon-alpha production (GO:0032727)2.53324434
151cell-cell junction maintenance (GO:0045217)2.52709184
152negative regulation of interleukin-6 production (GO:0032715)2.51917588
153retina vasculature morphogenesis in camera-type eye (GO:0061299)2.51661998
154purinergic receptor signaling pathway (GO:0035587)2.51415279
155negative regulation of norepinephrine secretion (GO:0010700)2.51380111
156negative regulation of smooth muscle cell migration (GO:0014912)2.50806363
157negative regulation of systemic arterial blood pressure (GO:0003085)2.50521926
158negative regulation of cartilage development (GO:0061037)2.49164138
159import into cell (GO:0098657)2.48719140
160positive regulation of smooth muscle cell migration (GO:0014911)2.47295444
161stress fiber assembly (GO:0043149)2.46837461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.47001183
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.79901162
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.91484772
4* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.69405014
5ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.65906441
6WT1_19549856_ChIP-ChIP_CCG9911_Human2.60117231
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.57838753
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.55973151
9* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.55755322
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.55685673
11* IRF8_27001747_Chip-Seq_BMDM_Mouse2.54675253
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.43164387
13CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.34703996
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.27721539
15CJUN_26792858_Chip-Seq_BT549_Human2.21279797
16CLOCK_20551151_ChIP-Seq_293T_Human2.11874471
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.08918709
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.08767914
19* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.98363862
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.97680593
21* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.97268494
22* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96965614
23* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93649907
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92229156
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82475059
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80327659
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78600699
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77232580
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76823562
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.69798633
31TCF3_18692474_ChIP-Seq_MEFs_Mouse1.66343162
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.65406181
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64179779
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63536057
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.62502672
36VDR_24787735_ChIP-Seq_THP-1_Human1.62252570
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62226994
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59517023
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59268370
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58305152
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57483625
42SA1_22415368_ChIP-Seq_MEFs_Mouse1.57412885
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56109733
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56109733
45P300_27058665_Chip-Seq_ZR-75-30cells_Human1.55642494
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54678415
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.50608454
48* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.50147920
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49961252
50BRD4_25478319_ChIP-Seq_HGPS_Human1.48803406
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48188587
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48183664
53MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.47319037
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45975908
55* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45572645
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.44444884
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.44098677
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41781397
59* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41391246
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40644985
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39872095
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38294683
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38294683
64RUNX_20019798_ChIP-Seq_JUKART_Human1.37701635
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37594616
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36299198
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35503636
68NFIB_24661679_ChIP-Seq_LUNG_Mouse1.35039933
69NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.34998737
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34128753
71* ISL1_27105846_Chip-Seq_CPCs_Mouse1.33325442
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32445792
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31705996
74SPI1_23127762_ChIP-Seq_K562_Human1.30355145
75EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.30266290
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29570372
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.29456513
78* ELK3_25401928_ChIP-Seq_HUVEC_Human1.29039366
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28424784
80ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27463882
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25405956
82TBX3_20139965_ChIP-Seq_ESCs_Mouse1.24996962
83TBX3_20139965_ChIP-Seq_MESCs_Mouse1.24289880
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.23895146
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23428287
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23293078
87RACK7_27058665_Chip-Seq_MCF-7_Human1.22581257
88SOX2_20726797_ChIP-Seq_SW620_Human1.21424778
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20747965
90TP53_23651856_ChIP-Seq_MEFs_Mouse1.19586367
91STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19380158
92TP53_18474530_ChIP-ChIP_U2OS_Human1.19378406
93SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18484437
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18484437
95DROSHA_22980978_ChIP-Seq_HELA_Human1.17526028
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17102944
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16432620
98EOMES_21245162_ChIP-Seq_HESCs_Human1.16214927
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15927422
100PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15363886
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15305026
102TP53_22127205_ChIP-Seq_IMR90_Human1.15297559
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15288540
104TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15070646
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14899947
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14899947
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14899947
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13615165
109UBF1/2_26484160_Chip-Seq_HMECs_Human1.13225797
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12781730
111SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11569615
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11249242
113SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09117743
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08607339
115TP53_16413492_ChIP-PET_HCT116_Human1.06797628
116SCL_19346495_ChIP-Seq_HPC-7_Human1.06359253
117CDX2_20551321_ChIP-Seq_CACO-2_Human1.05723698
118AR_21909140_ChIP-Seq_LNCAP_Human1.05575498
119* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05423792
120AR_21572438_ChIP-Seq_LNCaP_Human1.05206696
121SOX17_20123909_ChIP-Seq_XEN_Mouse1.05061572
122CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05018154
123TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04726282
124PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.04410106
125* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03682677
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02309925
127JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01002909
128WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99324696
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97995270
130TBX20_22080862_ChIP-Seq_HEART_Mouse0.97868498
131TBX20_22328084_ChIP-Seq_HEART_Mouse0.97868498
132TP53_20018659_ChIP-ChIP_R1E_Mouse0.96993072
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96002907
134NFI_21473784_ChIP-Seq_ESCs_Mouse0.95971488
135VDR_24763502_ChIP-Seq_THP-1_Human0.95477915
136TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.94799681
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94619053
138ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93710870
139MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93527114
140EZH2_27304074_Chip-Seq_ESCs_Mouse0.89393744
141GBX2_23144817_ChIP-Seq_PC3_Human0.88220244
142P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86816187
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.86059802
144PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85687698
145TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85685931
146AHR_22903824_ChIP-Seq_MCF-7_Human0.84546176

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.44571215
2MP0005503_abnormal_tendon_morphology6.21484999
3MP0005275_abnormal_skin_tensile5.08920295
4MP0003950_abnormal_plasma_membrane4.41110583
5MP0003279_aneurysm3.67154214
6MP0001958_emphysema3.28486442
7MP0002254_reproductive_system_inflammat2.88978107
8MP0003941_abnormal_skin_development2.71905262
9MP0006082_CNS_inflammation2.65284629
10MP0001542_abnormal_bone_strength2.65205363
11MP0009384_cardiac_valve_regurgitation2.63953242
12MP0003705_abnormal_hypodermis_morpholog2.55935943
13MP0004272_abnormal_basement_membrane2.38886741
14MP0005508_abnormal_skeleton_morphology2.33621261
15MP0003191_abnormal_cellular_cholesterol2.21885733
16MP0005058_abnormal_lysosome_morphology2.12203320
17MP0006054_spinal_hemorrhage2.05101017
18MP0005257_abnormal_intraocular_pressure1.98782948
19MP0002108_abnormal_muscle_morphology1.97946114
20MP0004233_abnormal_muscle_weight1.94939195
21MP0002998_abnormal_bone_remodeling1.86554362
22MP0005023_abnormal_wound_healing1.83321326
23MP0002933_joint_inflammation1.82534625
24MP0005390_skeleton_phenotype1.73778674
25MP0001533_abnormal_skeleton_physiology1.70918727
26MP0003566_abnormal_cell_adhesion1.66715155
27MP0000767_abnormal_smooth_muscle1.64544259
28MP0002060_abnormal_skin_morphology1.61003646
29MP0004883_abnormal_blood_vessel1.59577825
30MP0009780_abnormal_chondrocyte_physiolo1.59519033
31MP0003045_fibrosis1.53191270
32MP0003724_increased_susceptibility_to1.52333699
33MP0008004_abnormal_stomach_pH1.51313120
34MP0002896_abnormal_bone_mineralization1.50653752
35MP0010368_abnormal_lymphatic_system1.50564499
36MP0000343_altered_response_to1.49897020
37MP0003172_abnormal_lysosome_physiology1.42821675
38MP0004858_abnormal_nervous_system1.42250895
39MP0003385_abnormal_body_wall1.41732735
40MP0009250_abnormal_appendicular_skeleto1.41125483
41MP0002115_abnormal_skeleton_extremities1.31663789
42MP0003075_altered_response_to1.30268317
43MP0002282_abnormal_trachea_morphology1.29947705
44MP0002295_abnormal_pulmonary_circulatio1.28222517
45MP0001346_abnormal_lacrimal_gland1.26299880
46MP0005171_absent_coat_pigmentation1.24315193
47MP0000749_muscle_degeneration1.20391992
48MP0003252_abnormal_bile_duct1.18942677
49MP0003091_abnormal_cell_migration1.15699281
50MP0000163_abnormal_cartilage_morphology1.15088429
51MP0003795_abnormal_bone_structure1.15063455
52MP0004134_abnormal_chest_morphology1.13875393
53MP0001849_ear_inflammation1.13034994
54MP0001243_abnormal_dermal_layer1.10789487
55MP0000428_abnormal_craniofacial_morphol1.10540576
56MP0003300_gastrointestinal_ulcer1.10176703
57MP0002113_abnormal_skeleton_development1.08243754
58MP0005164_abnormal_response_to1.07557712
59MP0005623_abnormal_meninges_morphology1.04919903
60MP0003690_abnormal_glial_cell1.04604242
61MP0001835_abnormal_antigen_presentation1.03701842
62MP0001915_intracranial_hemorrhage1.03587150
63MP0005464_abnormal_platelet_physiology1.01779269
64MP0009053_abnormal_anal_canal1.01196264
65MP0010352_gastrointestinal_tract_polyps1.00136089
66MP0002419_abnormal_innate_immunity0.99128456
67MP0004185_abnormal_adipocyte_glucose0.99048520
68MP0000759_abnormal_skeletal_muscle0.98124672
69MP0002168_other_aberrant_phenotype0.94075206
70MP0005595_abnormal_vascular_smooth0.93217581
71MP0001879_abnormal_lymphatic_vessel0.90136379
72MP0002928_abnormal_bile_duct0.89821640
73MP0003303_peritoneal_inflammation0.89142135
74MP0000465_gastrointestinal_hemorrhage0.88891531
75MP0001661_extended_life_span0.87307342
76MP0000534_abnormal_ureter_morphology0.86934400
77MP0003828_pulmonary_edema0.86786941
78MP0000249_abnormal_blood_vessel0.85166985
79MP0001299_abnormal_eye_distance/0.83908415
80MP0001851_eye_inflammation0.83900090
81MP0005197_abnormal_uvea_morphology0.83794052
82MP0000762_abnormal_tongue_morphology0.83747540
83MP0005166_decreased_susceptibility_to0.83393380
84MP0005671_abnormal_response_to0.82716567
85MP0005165_increased_susceptibility_to0.81860203
86MP0000733_abnormal_muscle_development0.81506552
87MP0000750_abnormal_muscle_regeneration0.81341244
88MP0002109_abnormal_limb_morphology0.81165280
89MP0001175_abnormal_lung_morphology0.81075268
90MP0009278_abnormal_bone_marrow0.80945328
91MP0010030_abnormal_orbit_morphology0.79258599
92MP0004084_abnormal_cardiac_muscle0.79083520
93MP0002148_abnormal_hypersensitivity_rea0.77991693
94MP0002090_abnormal_vision0.76075694
95MP0003937_abnormal_limbs/digits/tail_de0.75241482
96MP0003959_abnormal_lean_body0.74920104
97MP0001614_abnormal_blood_vessel0.73591231
98MP0000751_myopathy0.73053305
99MP0005388_respiratory_system_phenotype0.72274697
100MP0002133_abnormal_respiratory_system0.72274697
101MP0002932_abnormal_joint_morphology0.71066790
102MP0005369_muscle_phenotype0.67951831
103MP0002128_abnormal_blood_circulation0.67932581
104MP0003448_altered_tumor_morphology0.67865444
105MP0006138_congestive_heart_failure0.67861388
106MP0003755_abnormal_palate_morphology0.67722914
107MP0002114_abnormal_axial_skeleton0.66528198
108MP0003942_abnormal_urinary_system0.66024058
109MP0003115_abnormal_respiratory_system0.65685981
110MP0002249_abnormal_larynx_morphology0.65599702
111MP0004036_abnormal_muscle_relaxation0.65206454
112MP0005076_abnormal_cell_differentiation0.64011175
113MP0000432_abnormal_head_morphology0.63101971
114MP0000462_abnormal_digestive_system0.62413015
115MP0003122_maternal_imprinting0.62350362
116MP0002111_abnormal_tail_morphology0.62282177
117MP0004087_abnormal_muscle_fiber0.61861180
118MP0003436_decreased_susceptibility_to0.61676808
119MP0002116_abnormal_craniofacial_bone0.61448029
120MP0001177_atelectasis0.60610350
121MP0005670_abnormal_white_adipose0.59787726
122MP0002396_abnormal_hematopoietic_system0.59001644
123MP0002452_abnormal_antigen_presenting0.58376261
124MP0000049_abnormal_middle_ear0.58346097
125MP0003935_abnormal_craniofacial_develop0.58147731
126MP0005620_abnormal_muscle_contractility0.57650623
127MP0008007_abnormal_cellular_replicative0.57231143
128MP0008932_abnormal_embryonic_tissue0.55769138
129MP0002925_abnormal_cardiovascular_devel0.55526934
130MP0002089_abnormal_postnatal_growth/wei0.55147471
131MP0003186_abnormal_redox_activity0.54860312
132MP0002269_muscular_atrophy0.54242938
133MP0009672_abnormal_birth_weight0.53916280
134MP0005193_abnormal_anterior_eye0.53893911
135MP0010386_abnormal_urinary_bladder0.53222572
136MP0000467_abnormal_esophagus_morphology0.51982204

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.00985843
2Premature rupture of membranes (HP:0001788)6.52507871
3Systemic lupus erythematosus (HP:0002725)6.46471518
4Aortic dissection (HP:0002647)5.91422730
5Cerebral aneurysm (HP:0004944)5.82700880
6Aortic aneurysm (HP:0004942)5.65030953
7Arterial tortuosity (HP:0005116)5.59455802
8Vascular tortuosity (HP:0004948)5.36967728
9Glomerulonephritis (HP:0000099)5.22002700
10Soft skin (HP:0000977)4.93737546
11Complement deficiency (HP:0004431)4.07886798
12Mitral valve prolapse (HP:0001634)3.86311447
13Abnormality of glycolipid metabolism (HP:0010969)3.84552131
14Abnormality of liposaccharide metabolism (HP:0010968)3.84552131
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.84552131
16Shallow orbits (HP:0000586)3.72096275
17Broad metatarsal (HP:0001783)3.70050601
18Follicular hyperkeratosis (HP:0007502)3.57227688
19Bladder diverticulum (HP:0000015)3.53519875
20Atrophic scars (HP:0001075)3.47234810
21Dilatation of the ascending aorta (HP:0005111)3.45633448
22Disproportionate tall stature (HP:0001519)3.42362858
23Ankle contracture (HP:0006466)3.41701834
24Spondylolisthesis (HP:0003302)3.40665960
25Vertebral compression fractures (HP:0002953)3.33207841
26Blue sclerae (HP:0000592)3.27173244
27Abnormality of complement system (HP:0005339)3.25288296
28Striae distensae (HP:0001065)3.25265236
29Cervical subluxation (HP:0003308)3.10118944
30Biconcave vertebral bodies (HP:0004586)3.05477612
31Hematochezia (HP:0002573)2.92568448
32Peritonitis (HP:0002586)2.92348377
33Fragile skin (HP:0001030)2.89605389
34Neonatal short-limb short stature (HP:0008921)2.86768334
35Wormian bones (HP:0002645)2.86469782
36Genu recurvatum (HP:0002816)2.82057615
37Abnormality of dentin (HP:0010299)2.75695779
38Camptodactyly of toe (HP:0001836)2.67937320
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.67024436
40Osteolytic defects of the hand bones (HP:0009699)2.67024436
41Nephritis (HP:0000123)2.66805772
42Type 1 muscle fiber predominance (HP:0003803)2.62835964
43Ileus (HP:0002595)2.62003957
44Dysostosis multiplex (HP:0000943)2.55637825
45Coronal craniosynostosis (HP:0004440)2.53802966
46Increased cerebral lipofuscin (HP:0011813)2.53655309
47Breech presentation (HP:0001623)2.51508658
48Hyperextensible skin (HP:0000974)2.51027976
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.49982763
50Joint stiffness (HP:0001387)2.49109192
51Retinal atrophy (HP:0001105)2.48458727
52Joint laxity (HP:0001388)2.47452629
53Increased variability in muscle fiber diameter (HP:0003557)2.40829793
54Abnormality of carpal bone ossification (HP:0006257)2.39057795
55Spinal rigidity (HP:0003306)2.37764535
56Mutism (HP:0002300)2.37520606
57Aortic valve stenosis (HP:0001650)2.36029083
58Aneurysm (HP:0002617)2.35140409
59Aplasia of the musculature (HP:0100854)2.34334541
60Abnormality of skeletal muscle fiber size (HP:0012084)2.32989118
61Broad ribs (HP:0000885)2.32864207
62Slender build (HP:0001533)2.31672720
63Delayed cranial suture closure (HP:0000270)2.30672018
64Wrist flexion contracture (HP:0001239)2.30480843
65Popliteal pterygium (HP:0009756)2.28938526
66Abnormality of the acetabulum (HP:0003170)2.25306222
67Back pain (HP:0003418)2.19862077
68Hypoventilation (HP:0002791)2.17676933
69Arnold-Chiari malformation (HP:0002308)2.14979734
70Overgrowth (HP:0001548)2.10305289
71Cupped ribs (HP:0000887)2.09301925
72Urethral obstruction (HP:0000796)2.08784969
73Thin ribs (HP:0000883)2.07277952
74Round ear (HP:0100830)2.06790222
75Elbow flexion contracture (HP:0002987)2.05956351
76Partial duplication of the phalanx of hand (HP:0009999)2.04228032
77Bowel diverticulosis (HP:0005222)2.04036946
78Thin skin (HP:0000963)2.04021287
79Spinal cord lesions (HP:0100561)2.03765025
80Syringomyelia (HP:0003396)2.03765025
81Bell-shaped thorax (HP:0001591)2.00072949
82Abnormal delivery (HP:0001787)1.99616514
83Osteoarthritis (HP:0002758)1.97865335
84Flexion contracture of toe (HP:0005830)1.96838819
85Joint contractures involving the joints of the feet (HP:0100492)1.96838819
86Abnormal ossification of hand bones (HP:0005921)1.96234953
87Mucopolysacchariduria (HP:0008155)1.96110035
88Urinary glycosaminoglycan excretion (HP:0003541)1.96110035
89Abnormality of the umbilical cord (HP:0010881)1.95039729
90Axonal loss (HP:0003447)1.93114260
91Wide anterior fontanel (HP:0000260)1.91258083
92Spinal cord compression (HP:0002176)1.90945641
93Short nail (HP:0001799)1.89403713
94Pterygium (HP:0001059)1.88898989
95Nemaline bodies (HP:0003798)1.88595841
96Distal lower limb muscle weakness (HP:0009053)1.87763961
97Abnormality of skull ossification (HP:0002703)1.87586417
98Mitral stenosis (HP:0001718)1.87441102
99Delayed closure of the anterior fontanelle (HP:0001476)1.85836526
100Flared iliac wings (HP:0002869)1.85747904
101Abnormality of polysaccharide metabolism (HP:0011012)1.85691727
102Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85691727
103Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85691727
104Deviation of the hallux (HP:0010051)1.85336340
105Deformed tarsal bones (HP:0008119)1.83913820
106Abnormal hand bone ossification (HP:0010660)1.83147157
107Thin bony cortex (HP:0002753)1.82642439
108Mild short stature (HP:0003502)1.82251481
109Hallux valgus (HP:0001822)1.81826559
110Calcaneovalgus deformity (HP:0001848)1.80990083
111Pathologic fracture (HP:0002756)1.80920135
112Mitral regurgitation (HP:0001653)1.80912254
113Congenital glaucoma (HP:0001087)1.80882863
114Ovoid vertebral bodies (HP:0003300)1.80831242
115Turricephaly (HP:0000262)1.80202811
116Disinhibition (HP:0000734)1.80187207
117Inguinal hernia (HP:0000023)1.79360183
118Bradycardia (HP:0001662)1.79159479
119Ulnar bowing (HP:0003031)1.78853883
120Myotonia (HP:0002486)1.78673212
121Orthostatic hypotension (HP:0001278)1.78365531
122Osteopenia (HP:0000938)1.77397443
123Increased connective tissue (HP:0009025)1.76340372
124Broad phalanx (HP:0006009)1.76013876
125Coxa vara (HP:0002812)1.74402476
126Ectopia lentis (HP:0001083)1.73584302
127Pulmonary artery stenosis (HP:0004415)1.71948931
128Mildly elevated creatine phosphokinase (HP:0008180)1.70672669
129Amyloidosis (HP:0011034)1.70196632
130Scapular winging (HP:0003691)1.70153697
131J-shaped sella turcica (HP:0002680)1.69269518
132Generalized amyotrophy (HP:0003700)1.68884598
133Abnormality of the peritoneum (HP:0002585)1.66920262
134Aortic regurgitation (HP:0001659)1.65437613
135Flat cornea (HP:0007720)1.64803165
136Broad long bones (HP:0005622)1.61445390
137Bicuspid aortic valve (HP:0001647)1.59496371
138Femoral bowing (HP:0002980)1.58710017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR28.99679368
2PDK23.94634277
3GRK73.71920072
4MAPK153.61860803
5DDR22.93864732
6CSF1R2.93696637
7VRK22.68876544
8RIPK12.58176189
9PNCK2.50304138
10NTRK12.49116311
11LRRK22.39696082
12MUSK2.30652594
13NEK92.15926716
14ROCK22.10434727
15LIMK12.06759286
16PDGFRA2.06697092
17PAK42.02622032
18ERN11.97463666
19PKN21.94751785
20TESK11.93109095
21TSSK61.72264671
22EPHA31.68731928
23PAK21.63724847
24MOS1.58888836
25MAPK121.58081588
26PRKG21.54188927
27CAMK1D1.44863854
28TYK21.44215986
29MAPK71.43120751
30TRIB31.39993820
31NEK61.36271194
32LATS21.35970526
33JAK11.32824165
34MAP3K81.30284058
35KIT1.21764585
36CDC42BPA1.21611651
37FER1.20945513
38PRKD21.19131726
39SIK11.17915966
40TTN1.17663762
41CLK11.13950939
42TAF11.12189044
43CAMK1G1.05053220
44STK101.04862979
45TBK11.03681355
46EPHB11.00284241
47ABL21.00130946
48EPHB20.99528001
49EIF2AK10.98896810
50MTOR0.98070342
51TRPM70.93076840
52DAPK30.92893562
53ERBB40.92591964
54MELK0.91391023
55CDK80.90891952
56TTK0.90332324
57ZAP700.88987302
58LATS10.85036358
59SMG10.84783737
60MYLK0.84327880
61PIK3CA0.83685630
62ILK0.83278596
63PBK0.82532007
64MAP2K10.80154522
65FLT30.78944183
66MAPKAPK50.78171548
67CAMKK20.78001632
68IRAK40.77836071
69HCK0.77562589
70DMPK0.76242126
71PTK60.73672463
72MAPKAPK30.73619658
73PLK20.73307927
74IGF1R0.72684770
75STK380.72244921
76CAMK40.71620681
77PDGFRB0.70712202
78IKBKB0.69554711
79PIK3CG0.69160277
80ERBB30.68218482
81PRKD30.67515951
82EIF2AK20.67419568
83STK160.67261337
84CAMK10.67157190
85ADRBK20.65793091
86CSK0.65523407
87PTK2B0.65448080
88MAPKAPK20.64714112
89MAP3K100.63741993
90PIM20.63225558
91STK30.62556870
92MATK0.62427241
93PAK10.60908520
94VRK10.60474023
95BLK0.60454923
96JAK20.60171367
97TGFBR10.60170334
98AURKB0.57301647
99PAK60.56137886
100INSR0.54674314
101MAP3K30.53524941
102CDK90.52808261
103SRPK10.51911655
104PRKD10.50730684
105PLK30.49969771
106CAMK2G0.49280519
107TIE10.49064764
108AKT30.48609215
109LYN0.46712503
110BMX0.46345354
111GRK50.46343659
112MAP2K30.44635653
113GSK3A0.43043903
114FGFR30.42396397
115MAP3K120.42378079
116ITK0.41424432
117JAK30.41285220
118FGFR20.40413027
119RPS6KA40.38704613
120RPS6KA20.38574108
121CDK30.38136179
122LCK0.37874359
123FGFR40.37135936
124RET0.36925911
125CAMKK10.36743369
126EEF2K0.36206036
127GRK10.34131597
128CDK150.33836785
129PDK10.33195292
130ROCK10.33139037
131CDK11A0.31493081
132MAPK40.30833618
133SRC0.30056774
134ADRBK10.29931309
135PRKCE0.29472064
136WNK10.29375088
137CDK60.28793363
138STK38L0.28375421
139FRK0.28298935
140PTK20.28212170
141CDK180.27922683
142LMTK20.27577802
143EGFR0.26878985
144IRAK30.26750421
145IRAK10.26570833
146CDK140.26407436
147ERBB20.25930229
148RIPK40.24967688
149MET0.24220119
150CHUK0.23867839
151PDPK10.23864773

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.06000229
2Other glycan degradation_Homo sapiens_hsa005113.70999648
3Staphylococcus aureus infection_Homo sapiens_hsa051503.54038758
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.07090551
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.73092538
6ECM-receptor interaction_Homo sapiens_hsa045122.67367865
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.58103416
8Lysosome_Homo sapiens_hsa041422.45470556
9Osteoclast differentiation_Homo sapiens_hsa043802.12841731
10Prion diseases_Homo sapiens_hsa050202.07141545
11Malaria_Homo sapiens_hsa051442.00314296
12Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.88985928
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.82596451
14Pertussis_Homo sapiens_hsa051331.80652268
15Focal adhesion_Homo sapiens_hsa045101.80095254
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.78024074
17Protein digestion and absorption_Homo sapiens_hsa049741.66449639
18Leishmaniasis_Homo sapiens_hsa051401.66269963
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49534990
20Adherens junction_Homo sapiens_hsa045201.48649460
21Glutathione metabolism_Homo sapiens_hsa004801.44517194
22Tight junction_Homo sapiens_hsa045301.43495682
23TGF-beta signaling pathway_Homo sapiens_hsa043501.43471249
24Toxoplasmosis_Homo sapiens_hsa051451.40492078
25Chronic myeloid leukemia_Homo sapiens_hsa052201.39645032
26Amoebiasis_Homo sapiens_hsa051461.31888644
27Antigen processing and presentation_Homo sapiens_hsa046121.31519525
28Pancreatic cancer_Homo sapiens_hsa052121.30569284
29Complement and coagulation cascades_Homo sapiens_hsa046101.23065867
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21620159
31Gap junction_Homo sapiens_hsa045401.20653576
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18736802
33Platelet activation_Homo sapiens_hsa046111.15552675
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15363234
35Proteoglycans in cancer_Homo sapiens_hsa052051.15128098
36Dilated cardiomyopathy_Homo sapiens_hsa054141.13363655
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12381012
38B cell receptor signaling pathway_Homo sapiens_hsa046621.10294092
39Melanogenesis_Homo sapiens_hsa049161.07505962
40Galactose metabolism_Homo sapiens_hsa000521.07346298
41PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04523137
42Thyroid cancer_Homo sapiens_hsa052161.04355425
43Phagosome_Homo sapiens_hsa041451.04349227
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04117460
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02655971
46Tuberculosis_Homo sapiens_hsa051521.01785658
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.98366415
48Colorectal cancer_Homo sapiens_hsa052100.98296174
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96649716
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.96499896
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96229105
52Legionellosis_Homo sapiens_hsa051340.95405857
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95014132
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91159047
55N-Glycan biosynthesis_Homo sapiens_hsa005100.90669362
56Notch signaling pathway_Homo sapiens_hsa043300.90003816
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.89573986
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88527916
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88204567
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86780565
61Sphingolipid metabolism_Homo sapiens_hsa006000.85821155
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85432217
63Rheumatoid arthritis_Homo sapiens_hsa053230.85305987
64TNF signaling pathway_Homo sapiens_hsa046680.84943010
65Endocytosis_Homo sapiens_hsa041440.84167591
66Hepatitis B_Homo sapiens_hsa051610.82973677
67Arachidonic acid metabolism_Homo sapiens_hsa005900.80020469
68Rap1 signaling pathway_Homo sapiens_hsa040150.79992831
69Small cell lung cancer_Homo sapiens_hsa052220.79941144
70Renin-angiotensin system_Homo sapiens_hsa046140.79032956
71Salmonella infection_Homo sapiens_hsa051320.78532956
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76232422
73Vibrio cholerae infection_Homo sapiens_hsa051100.74434182
74Melanoma_Homo sapiens_hsa052180.73383266
75Apoptosis_Homo sapiens_hsa042100.73115708
76Prostate cancer_Homo sapiens_hsa052150.73093926
77Chemokine signaling pathway_Homo sapiens_hsa040620.72763144
78Hippo signaling pathway_Homo sapiens_hsa043900.72083450
79Pathways in cancer_Homo sapiens_hsa052000.71985599
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71304060
81Renal cell carcinoma_Homo sapiens_hsa052110.71051124
82Hematopoietic cell lineage_Homo sapiens_hsa046400.69076093
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68166177
84Glioma_Homo sapiens_hsa052140.68111440
85Estrogen signaling pathway_Homo sapiens_hsa049150.68087622
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66633201
87Measles_Homo sapiens_hsa051620.66275054
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64725270
89Folate biosynthesis_Homo sapiens_hsa007900.63838480
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62504629
91Viral myocarditis_Homo sapiens_hsa054160.60051942
92Sulfur relay system_Homo sapiens_hsa041220.59912855
93MicroRNAs in cancer_Homo sapiens_hsa052060.59713881
94HTLV-I infection_Homo sapiens_hsa051660.59158187
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.58521148
96Basal cell carcinoma_Homo sapiens_hsa052170.58445360
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.57883112
98Influenza A_Homo sapiens_hsa051640.57758656
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56182022
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55267504
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.53356635
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.53269685
103Ras signaling pathway_Homo sapiens_hsa040140.52653199
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51645980
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51470550
106Axon guidance_Homo sapiens_hsa043600.51301424
107Hedgehog signaling pathway_Homo sapiens_hsa043400.50265412
108Shigellosis_Homo sapiens_hsa051310.50159602
109MAPK signaling pathway_Homo sapiens_hsa040100.49557651
110FoxO signaling pathway_Homo sapiens_hsa040680.49046910
111Wnt signaling pathway_Homo sapiens_hsa043100.48002207
112Biosynthesis of amino acids_Homo sapiens_hsa012300.47292371
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46312876
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46089146
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44517437
116p53 signaling pathway_Homo sapiens_hsa041150.44490211
117Ether lipid metabolism_Homo sapiens_hsa005650.44444032
118Endometrial cancer_Homo sapiens_hsa052130.43971604
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43863128
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42804277
121Thyroid hormone synthesis_Homo sapiens_hsa049180.41700571
122Selenocompound metabolism_Homo sapiens_hsa004500.41407855
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41032492
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.40341347
125HIF-1 signaling pathway_Homo sapiens_hsa040660.39810468
126Bladder cancer_Homo sapiens_hsa052190.37649720
127Lysine degradation_Homo sapiens_hsa003100.37507696
128GnRH signaling pathway_Homo sapiens_hsa049120.37359307
129Renin secretion_Homo sapiens_hsa049240.36371675
130Nucleotide excision repair_Homo sapiens_hsa034200.35447347
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33733644
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33463837
133Pentose phosphate pathway_Homo sapiens_hsa000300.32588649
134Fatty acid elongation_Homo sapiens_hsa000620.32156574
135One carbon pool by folate_Homo sapiens_hsa006700.30345949
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29613949
137Proteasome_Homo sapiens_hsa030500.29449119
138Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29124136
139Mineral absorption_Homo sapiens_hsa049780.26521312
140AMPK signaling pathway_Homo sapiens_hsa041520.23509374
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22886056

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