OLIG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.80208830
2central nervous system myelination (GO:0022010)9.80208830
3* myelination (GO:0042552)6.46684356
4* ensheathment of neurons (GO:0007272)6.44221531
5* axon ensheathment (GO:0008366)6.44221531
6oligodendrocyte differentiation (GO:0048709)5.80845253
7fatty acid elongation (GO:0030497)5.59959604
8photoreceptor cell differentiation (GO:0046530)5.15039154
9eye photoreceptor cell differentiation (GO:0001754)5.15039154
10neuron cell-cell adhesion (GO:0007158)5.14927900
11exploration behavior (GO:0035640)5.11451955
12negative regulation of neurotransmitter secretion (GO:0046929)5.08515714
13regulation of respiratory gaseous exchange by neurological system process (GO:0002087)5.01262888
14creatine metabolic process (GO:0006600)5.00917405
15cellular potassium ion homeostasis (GO:0030007)4.89780978
16potassium ion import (GO:0010107)4.81131443
17presynaptic membrane assembly (GO:0097105)4.67154725
18astrocyte development (GO:0014002)4.64597926
19negative regulation of neurotransmitter transport (GO:0051589)4.63773971
20long-chain fatty acid biosynthetic process (GO:0042759)4.50351655
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.50174198
22potassium ion homeostasis (GO:0055075)4.49505341
23sodium ion export (GO:0071436)4.46500709
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.46036963
25presynaptic membrane organization (GO:0097090)4.43479903
26positive regulation of osteoblast proliferation (GO:0033690)4.34250665
27asymmetric protein localization (GO:0008105)4.30771054
28apical protein localization (GO:0045176)4.27630386
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.19615121
30L-amino acid import (GO:0043092)4.19579011
31amino acid import (GO:0043090)4.17579524
32peripheral nervous system axon ensheathment (GO:0032292)4.06951820
33myelination in peripheral nervous system (GO:0022011)4.06951820
34cholesterol biosynthetic process (GO:0006695)4.05687384
35substantia nigra development (GO:0021762)4.04988474
36neurotransmitter uptake (GO:0001504)4.01860599
37mechanosensory behavior (GO:0007638)3.90620360
38negative regulation of protein localization to cell surface (GO:2000009)3.89059937
39negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.88612995
40regulation of respiratory system process (GO:0044065)3.86308784
41vocalization behavior (GO:0071625)3.81027551
42neurotransmitter-gated ion channel clustering (GO:0072578)3.80599979
43negative regulation of axon extension (GO:0030517)3.68707408
44synaptic vesicle maturation (GO:0016188)3.66267662
45neuron projection regeneration (GO:0031102)3.64244735
46cerebral cortex radially oriented cell migration (GO:0021799)3.63370396
47locomotory exploration behavior (GO:0035641)3.60188380
48glial cell differentiation (GO:0010001)3.59845061
49peptidyl-tyrosine autophosphorylation (GO:0038083)3.59149870
50regulation of synapse structural plasticity (GO:0051823)3.58865497
51negative regulation of axonogenesis (GO:0050771)3.58129417
52auditory behavior (GO:0031223)3.57962605
53Leydig cell differentiation (GO:0033327)3.57477758
54myelin maintenance (GO:0043217)3.56931627
55regulation of synaptic vesicle exocytosis (GO:2000300)3.56494103
56synaptic transmission, glutamatergic (GO:0035249)3.53171673
57enteric nervous system development (GO:0048484)3.52614933
58acidic amino acid transport (GO:0015800)3.50513637
59regulation of glutamate receptor signaling pathway (GO:1900449)3.48215522
60regulation of neuronal synaptic plasticity (GO:0048168)3.47455868
61sterol biosynthetic process (GO:0016126)3.47133612
62synaptic vesicle docking involved in exocytosis (GO:0016081)3.45014548
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45002267
64transmission of nerve impulse (GO:0019226)3.44994532
65regulation of collateral sprouting (GO:0048670)3.44151807
66cAMP-mediated signaling (GO:0019933)3.43022312
67regulation of axon regeneration (GO:0048679)3.41521945
68regulation of neuron projection regeneration (GO:0070570)3.41521945
69glycerophospholipid catabolic process (GO:0046475)3.41302146
70growth hormone secretion (GO:0030252)3.41025942
71protein localization to synapse (GO:0035418)3.34233042
72response to lipoprotein particle (GO:0055094)3.33796364
73synaptic vesicle exocytosis (GO:0016079)3.31238957
74glutamate secretion (GO:0014047)3.31134656
75regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30416046
76lens fiber cell development (GO:0070307)3.30166649
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.30046903
78dermatan sulfate biosynthetic process (GO:0030208)3.30018011
79establishment of mitochondrion localization (GO:0051654)3.27280048
80regulation of neurotransmitter uptake (GO:0051580)3.25555899
81limb bud formation (GO:0060174)3.24499556
82positive regulation of growth hormone secretion (GO:0060124)3.24406297
83cyclic-nucleotide-mediated signaling (GO:0019935)3.21182867
84dendrite morphogenesis (GO:0048813)3.20321658
85cerebellar Purkinje cell layer development (GO:0021680)3.19311157
86virion attachment to host cell (GO:0019062)3.18961658
87adhesion of symbiont to host cell (GO:0044650)3.18961658
88chondroitin sulfate biosynthetic process (GO:0030206)3.18747294
89Sertoli cell development (GO:0060009)3.18672516
90* positive regulation of gliogenesis (GO:0014015)3.15939775
91astrocyte differentiation (GO:0048708)3.15786683
92cerebellar granule cell differentiation (GO:0021707)3.14872881
93cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.14231818
94neuromuscular process controlling balance (GO:0050885)3.12264319
95positive regulation of neurological system process (GO:0031646)3.11269654
96regulation of synaptic transmission, glutamatergic (GO:0051966)3.10824160
97negative regulation of myoblast differentiation (GO:0045662)3.09889820
98regulation of short-term neuronal synaptic plasticity (GO:0048172)3.09361622
99negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.09203784
100response to auditory stimulus (GO:0010996)3.08918281
101positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.08673385
102glutamate receptor signaling pathway (GO:0007215)3.07593806
103cellular sodium ion homeostasis (GO:0006883)3.07564629
104membrane hyperpolarization (GO:0060081)3.06981711
105regulation of growth hormone secretion (GO:0060123)3.06895303
106regulation of synaptic vesicle transport (GO:1902803)3.06637662
107L-glutamate transport (GO:0015813)3.06465951
108mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.03303090
109long-term synaptic potentiation (GO:0060291)3.03008565
110peripheral nervous system development (GO:0007422)3.01633602
111isoprenoid biosynthetic process (GO:0008299)3.01538925
112positive regulation of p38MAPK cascade (GO:1900745)3.01415633
113protein palmitoylation (GO:0018345)3.00554827
114regulation of respiratory gaseous exchange (GO:0043576)2.99088826
115response to methylmercury (GO:0051597)2.98819649
116glial cell development (GO:0021782)2.98616170
117regulation of circadian sleep/wake cycle (GO:0042749)2.97309861
118regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.97309861
119activated T cell proliferation (GO:0050798)2.97086701
120dermatan sulfate metabolic process (GO:0030205)2.92022454
121regulation of somitogenesis (GO:0014807)2.91451567
122* regulation of gliogenesis (GO:0014013)2.91042109
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90810986
124adult walking behavior (GO:0007628)2.90575795
125neuron recognition (GO:0008038)2.90239311
126positive regulation of actin filament depolymerization (GO:0030836)2.89624834
127neurotransmitter secretion (GO:0007269)2.89420940
128long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.88524893
129regulation of long-term neuronal synaptic plasticity (GO:0048169)2.87244419
130neuronal ion channel clustering (GO:0045161)2.86782813
131neuroblast proliferation (GO:0007405)2.85104819
132regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.84757406
133lateral sprouting from an epithelium (GO:0060601)2.81639870
134innervation (GO:0060384)2.81104193
135nephron tubule formation (GO:0072079)2.80058825
136neural nucleus development (GO:0048857)2.79899494
137dendritic spine morphogenesis (GO:0060997)2.79841633
138negative regulation of smoothened signaling pathway (GO:0045879)2.79163195
139* positive regulation of oligodendrocyte differentiation (GO:0048714)2.77845927
140chondroitin sulfate catabolic process (GO:0030207)2.77761909
141import into cell (GO:0098657)2.77028777
142nerve growth factor signaling pathway (GO:0038180)2.74186985
143positive regulation of astrocyte differentiation (GO:0048711)2.73084613
144* positive regulation of glial cell differentiation (GO:0045687)2.70180650
145mammary gland alveolus development (GO:0060749)2.69916958
146response to redox state (GO:0051775)2.69368598
147cellular response to epinephrine stimulus (GO:0071872)2.66534652
148very long-chain fatty acid metabolic process (GO:0000038)2.66471447
149neurotransmitter catabolic process (GO:0042135)2.66169807
150* regulation of oligodendrocyte differentiation (GO:0048713)2.66047947
151axon development (GO:0061564)2.65525325
152substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.64584396
153substrate-independent telencephalic tangential migration (GO:0021826)2.64584396
154axonal fasciculation (GO:0007413)2.63276572
155postsynaptic membrane organization (GO:0001941)2.62114077
156positive regulation of synapse assembly (GO:0051965)2.60360980
157L-serine transport (GO:0015825)2.56231005
158layer formation in cerebral cortex (GO:0021819)2.53555501
159Rap protein signal transduction (GO:0032486)2.51611199
160peptidyl-cysteine modification (GO:0018198)2.50750596
161positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.47321380
162membrane assembly (GO:0071709)2.47236499
163* regulation of glial cell differentiation (GO:0045685)2.46130656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.99120855
2GBX2_23144817_ChIP-Seq_PC3_Human3.53212314
3AR_21572438_ChIP-Seq_LNCaP_Human2.89685872
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88163497
5SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.74855184
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74374700
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.63778053
8* EZH2_27304074_Chip-Seq_ESCs_Mouse2.60121153
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57188978
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57188978
11* EED_16625203_ChIP-ChIP_MESCs_Mouse2.40828179
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39697393
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37417551
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28705870
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25368695
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.25011348
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23851852
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.20442423
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19352682
20* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.13830748
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13718258
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.11703019
23* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.07746576
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06746038
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.98488200
26DROSHA_22980978_ChIP-Seq_HELA_Human1.96451442
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.94255938
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88482611
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86885123
30TAF15_26573619_Chip-Seq_HEK293_Human1.81220595
31* CBX2_27304074_Chip-Seq_ESCs_Mouse1.75517021
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.73675936
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72099497
34EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.69974562
35* SMAD3_21741376_ChIP-Seq_EPCs_Human1.69277561
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.68815399
37* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67027072
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66240978
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64738634
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61567753
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.60811686
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59751023
43KDM2B_26808549_Chip-Seq_K562_Human1.59623082
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56954490
45REST_21632747_ChIP-Seq_MESCs_Mouse1.55049847
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50485289
47* RING1B_27294783_Chip-Seq_ESCs_Mouse1.48081866
48* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47034716
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46460803
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46235636
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44009541
52* RING1B_27294783_Chip-Seq_NPCs_Mouse1.42987988
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41614963
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40624064
55STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.39621275
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37748231
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35650203
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.35022666
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33744820
60* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31094141
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29057874
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28893223
63ER_23166858_ChIP-Seq_MCF-7_Human1.25211839
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.24198772
65FUS_26573619_Chip-Seq_HEK293_Human1.21446597
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17975407
67SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.17682038
68* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16610789
69POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12551609
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.11777995
71STAT3_23295773_ChIP-Seq_U87_Human1.11542068
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10817983
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10433242
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10391302
75CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10286598
76P300_19829295_ChIP-Seq_ESCs_Human1.10269483
77LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08991758
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07414936
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07296601
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.06040448
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05921474
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.05213427
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05115932
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04792379
85ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04080894
86GATA1_26923725_Chip-Seq_HPCs_Mouse1.02289990
87SMAD3_21741376_ChIP-Seq_ESCs_Human1.01994736
88RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01905994
89LXR_22292898_ChIP-Seq_THP-1_Human1.01596150
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.01531627
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.01331085
92* ERG_21242973_ChIP-ChIP_JURKAT_Human1.01282949
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01104716
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.00797373
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00306619
96* SMAD4_21799915_ChIP-Seq_A2780_Human1.00279082
97AR_19668381_ChIP-Seq_PC3_Human1.00230544
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99272373
99AHR_22903824_ChIP-Seq_MCF-7_Human0.98667790
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98117601
101CTCF_27219007_Chip-Seq_Bcells_Human0.97265627
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97070825
103POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96460250
104LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95688150
105DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94164375
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93998389
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93998389
108* SOX9_26525672_Chip-Seq_HEART_Mouse0.93961837
109* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90601376
110TP53_23651856_ChIP-Seq_MEFs_Mouse0.90327408
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.89957795
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89730035
113NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89181947
114NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89046830
115* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88554353
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88515014
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87980624
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87836732
119* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87288698
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.86586730
121CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86511849
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86282999
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86113349
124RNF2_27304074_Chip-Seq_NSC_Mouse0.85254723
125* TCF4_23295773_ChIP-Seq_U87_Human0.83646762
126* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83401191
127SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83160399
128* TP53_20018659_ChIP-ChIP_R1E_Mouse0.82485751
129TET1_21490601_ChIP-Seq_MESCs_Mouse0.82326340
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81910872
131SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80565844
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79939120
133SOX3_22085726_ChIP-Seq_NPCs_Mouse0.79434849
134ISL1_27105846_Chip-Seq_CPCs_Mouse0.79421668
135OCT4_19829295_ChIP-Seq_ESCs_Human0.79210942
136KLF4_19829295_ChIP-Seq_ESCs_Human0.79131552
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77274253
138SMC4_20622854_ChIP-Seq_HELA_Human0.76956129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.60390758
2MP0003880_abnormal_central_pattern4.01730446
3MP0003136_yellow_coat_color3.32333367
4MP0004859_abnormal_synaptic_plasticity3.16656319
5MP0005167_abnormal_blood-brain_barrier2.87397265
6MP0003690_abnormal_glial_cell2.86825091
7* MP0000778_abnormal_nervous_system2.84048630
8MP0004270_analgesia2.81533106
9* MP0003634_abnormal_glial_cell2.73865221
10MP0004885_abnormal_endolymph2.66139636
11MP0001486_abnormal_startle_reflex2.53199822
12MP0004742_abnormal_vestibular_system2.44467173
13MP0002064_seizures2.41088995
14MP0001485_abnormal_pinna_reflex2.40213188
15MP0005171_absent_coat_pigmentation2.29980240
16MP0003950_abnormal_plasma_membrane2.23883663
17MP0003635_abnormal_synaptic_transmissio2.21003143
18MP0002272_abnormal_nervous_system2.18029728
19MP0003787_abnormal_imprinting2.16979871
20MP0005423_abnormal_somatic_nervous2.16649805
21MP0003329_amyloid_beta_deposits2.14812247
22MP0009745_abnormal_behavioral_response2.03397321
23MP0004858_abnormal_nervous_system1.99038825
24MP0001529_abnormal_vocalization1.95693698
25MP0002735_abnormal_chemical_nociception1.93141793
26MP0005623_abnormal_meninges_morphology1.86217638
27MP0001905_abnormal_dopamine_level1.85270098
28MP0004134_abnormal_chest_morphology1.83279380
29MP0010678_abnormal_skin_adnexa1.79515408
30* MP0000955_abnormal_spinal_cord1.77572189
31MP0003183_abnormal_peptide_metabolism1.77517867
32MP0002063_abnormal_learning/memory/cond1.76085186
33MP0003632_abnormal_nervous_system1.74045532
34MP0002653_abnormal_ependyma_morphology1.60716287
35MP0005645_abnormal_hypothalamus_physiol1.59855176
36MP0003123_paternal_imprinting1.59371136
37MP0002572_abnormal_emotion/affect_behav1.59331805
38* MP0002882_abnormal_neuron_morphology1.59004084
39MP0000383_abnormal_hair_follicle1.53279918
40MP0000462_abnormal_digestive_system1.52456399
41MP0001501_abnormal_sleep_pattern1.47323095
42MP0000467_abnormal_esophagus_morphology1.45692327
43MP0001299_abnormal_eye_distance/1.44957716
44MP0009046_muscle_twitch1.43672609
45MP0002229_neurodegeneration1.42365524
46* MP0002152_abnormal_brain_morphology1.41800880
47* MP0004142_abnormal_muscle_tone1.40615637
48* MP0002067_abnormal_sensory_capabilities1.39998739
49MP0000631_abnormal_neuroendocrine_gland1.39717882
50MP0002734_abnormal_mechanical_nocicepti1.38551228
51MP0003879_abnormal_hair_cell1.37895528
52MP0005409_darkened_coat_color1.32995003
53MP0005379_endocrine/exocrine_gland_phen1.32469372
54MP0001440_abnormal_grooming_behavior1.31050492
55* MP0002066_abnormal_motor_capabilities/c1.29274934
56MP0002557_abnormal_social/conspecific_i1.28766878
57MP0003937_abnormal_limbs/digits/tail_de1.28667056
58MP0000647_abnormal_sebaceous_gland1.28527716
59MP0002752_abnormal_somatic_nervous1.27935287
60MP0001984_abnormal_olfaction1.25740919
61MP0002184_abnormal_innervation1.23812376
62MP0002249_abnormal_larynx_morphology1.23088809
63MP0002736_abnormal_nociception_after1.20686841
64* MP0003861_abnormal_nervous_system1.19931148
65MP0003938_abnormal_ear_development1.19211450
66MP0001963_abnormal_hearing_physiology1.17639224
67MP0005551_abnormal_eye_electrophysiolog1.16972414
68MP0009250_abnormal_appendicular_skeleto1.16640540
69MP0001968_abnormal_touch/_nociception1.14242453
70MP0008569_lethality_at_weaning1.13669142
71MP0002733_abnormal_thermal_nociception1.13618105
72MP0005646_abnormal_pituitary_gland1.09925766
73MP0004130_abnormal_muscle_cell1.09165261
74MP0000762_abnormal_tongue_morphology1.08620915
75MP0003631_nervous_system_phenotype1.07769620
76MP0001970_abnormal_pain_threshold1.05992667
77MP0005410_abnormal_fertilization1.03727232
78MP0003075_altered_response_to1.02321555
79MP0001502_abnormal_circadian_rhythm1.00463432
80MP0002909_abnormal_adrenal_gland0.99456774
81MP0000026_abnormal_inner_ear0.99419406
82MP0005195_abnormal_posterior_eye0.98305428
83MP0001177_atelectasis0.98192409
84MP0005386_behavior/neurological_phenoty0.97373685
85MP0004924_abnormal_behavior0.97373685
86MP0006276_abnormal_autonomic_nervous0.97076619
87MP0000579_abnormal_nail_morphology0.90368023
88MP0002233_abnormal_nose_morphology0.87494440
89MP0000534_abnormal_ureter_morphology0.87363857
90* MP0004811_abnormal_neuron_physiology0.85658416
91MP0003633_abnormal_nervous_system0.84372707
92MP0006072_abnormal_retinal_apoptosis0.83667106
93MP0000639_abnormal_adrenal_gland0.82784490
94MP0003755_abnormal_palate_morphology0.82696096
95MP0003122_maternal_imprinting0.81972166
96MP0001346_abnormal_lacrimal_gland0.81842309
97MP0000566_synostosis0.80826673
98MP0001340_abnormal_eyelid_morphology0.77592306
99MP0000733_abnormal_muscle_development0.77433301
100MP0004381_abnormal_hair_follicle0.77374445
101MP0001958_emphysema0.76844653
102MP0000604_amyloidosis0.76597086
103MP0009780_abnormal_chondrocyte_physiolo0.76384031
104MP0000747_muscle_weakness0.75989584
105* MP0001943_abnormal_respiration0.75730782
106MP0003172_abnormal_lysosome_physiology0.75672424
107MP0000428_abnormal_craniofacial_morphol0.74395951
108MP0002822_catalepsy0.74144030
109MP0004043_abnormal_pH_regulation0.72491696
110MP0002638_abnormal_pupillary_reflex0.72305636
111MP0001986_abnormal_taste_sensitivity0.70361507
112MP0002090_abnormal_vision0.69576949
113* MP0002069_abnormal_eating/drinking_beha0.68217621
114MP0009278_abnormal_bone_marrow0.67332428
115MP0001661_extended_life_span0.67110586
116MP0005253_abnormal_eye_physiology0.66544436
117MP0001293_anophthalmia0.66320982
118MP0004145_abnormal_muscle_electrophysio0.65738216
119MP0002108_abnormal_muscle_morphology0.64870187
120MP0009379_abnormal_foot_pigmentation0.64238787
121MP0000537_abnormal_urethra_morphology0.64232701
122MP0002163_abnormal_gland_morphology0.62971749
123MP0003119_abnormal_digestive_system0.54538284
124MP0005535_abnormal_body_temperature0.54208603
125MP0001731_abnormal_postnatal_growth0.53371939
126MP0005670_abnormal_white_adipose0.53113849
127MP0005595_abnormal_vascular_smooth0.52535924
128MP0003137_abnormal_impulse_conducting0.49417564
129MP0010769_abnormal_survival0.48883775
130MP0005394_taste/olfaction_phenotype0.48543597
131MP0005499_abnormal_olfactory_system0.48543597
132MP0010770_preweaning_lethality0.47067407
133MP0002082_postnatal_lethality0.47067407

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.86543955
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.86543955
3Neurofibrillary tangles (HP:0002185)5.05189685
4Abnormality of the corticospinal tract (HP:0002492)4.49885343
5Peripheral hypomyelination (HP:0007182)4.39824725
6Sensory axonal neuropathy (HP:0003390)4.31390260
7Obstructive sleep apnea (HP:0002870)4.22029998
8Focal motor seizures (HP:0011153)4.06238213
9Diplopia (HP:0000651)4.01143664
10Abnormality of binocular vision (HP:0011514)4.01143664
11Septo-optic dysplasia (HP:0100842)3.90761381
12Cerebral inclusion bodies (HP:0100314)3.86625639
13Megalencephaly (HP:0001355)3.67583207
14Parakeratosis (HP:0001036)3.57983710
15Absent septum pellucidum (HP:0001331)3.55276338
16Cerebral hypomyelination (HP:0006808)3.41199301
17Spastic gait (HP:0002064)3.38832822
18Retinal dysplasia (HP:0007973)3.35427374
19Abnormal auditory evoked potentials (HP:0006958)3.34282120
20Split foot (HP:0001839)3.33977091
21Supranuclear gaze palsy (HP:0000605)3.32538441
22Alacrima (HP:0000522)3.27585026
23Termporal pattern (HP:0011008)3.25266492
24Insidious onset (HP:0003587)3.25266492
25Hypoplastic pelvis (HP:0008839)3.24788301
26Focal seizures (HP:0007359)3.13509245
27Coronal craniosynostosis (HP:0004440)3.10181022
28Abnormal eating behavior (HP:0100738)3.09381461
29Abnormality of the 4th metacarpal (HP:0010012)3.08420056
30Myokymia (HP:0002411)3.06238192
31Hemiplegia (HP:0002301)3.02522182
32Abnormality of the septum pellucidum (HP:0007375)2.95956435
33Abnormality of cochlea (HP:0000375)2.93000861
34Relative macrocephaly (HP:0004482)2.92157160
35Metabolic alkalosis (HP:0200114)2.91894628
36Insomnia (HP:0100785)2.90987408
37Premature skin wrinkling (HP:0100678)2.85054012
38Intention tremor (HP:0002080)2.84967467
39Anteriorly placed anus (HP:0001545)2.83547739
40Akinesia (HP:0002304)2.82333667
41Epileptic encephalopathy (HP:0200134)2.82197012
42Hepatoblastoma (HP:0002884)2.79052718
43Oligodactyly (hands) (HP:0001180)2.76901351
44Pheochromocytoma (HP:0002666)2.76637779
45Onion bulb formation (HP:0003383)2.75368093
46Esophageal atresia (HP:0002032)2.74665573
47Morphological abnormality of the inner ear (HP:0011390)2.74023695
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.66560829
49Dysmetria (HP:0001310)2.65548289
50Truncus arteriosus (HP:0001660)2.63832731
51Hemiparesis (HP:0001269)2.63346052
52Decreased lacrimation (HP:0000633)2.61300139
53Humeroradial synostosis (HP:0003041)2.61063421
54Synostosis involving the elbow (HP:0003938)2.61063421
55Hypokalemic alkalosis (HP:0001949)2.60999353
56Congenital malformation of the right heart (HP:0011723)2.60972592
57Double outlet right ventricle (HP:0001719)2.60972592
58Hyperacusis (HP:0010780)2.58968652
59Generalized tonic-clonic seizures (HP:0002069)2.58551686
60Overgrowth (HP:0001548)2.54082146
61Sleep apnea (HP:0010535)2.52958162
62Febrile seizures (HP:0002373)2.48408087
63Ankle clonus (HP:0011448)2.47628629
64Leukodystrophy (HP:0002415)2.41044870
65Elfin facies (HP:0004428)2.38981345
66Aplasia involving bones of the upper limbs (HP:0009823)2.37622723
67Aplasia of the phalanges of the hand (HP:0009802)2.37622723
68Aplasia involving bones of the extremities (HP:0009825)2.37622723
69Spastic paraparesis (HP:0002313)2.35646279
70Neuroendocrine neoplasm (HP:0100634)2.34248213
71Abnormality of glycolysis (HP:0004366)2.31695252
72Increased serum pyruvate (HP:0003542)2.31695252
73Hyperparathyroidism (HP:0000843)2.30708901
74Chin dimple (HP:0010751)2.29387685
75Thickened helices (HP:0000391)2.27304181
76Fibular hypoplasia (HP:0003038)2.24499985
77Germ cell neoplasia (HP:0100728)2.24401291
78Lower limb muscle weakness (HP:0007340)2.23864129
79Hypoplasia of the iris (HP:0007676)2.23863404
80Increased circulating renin level (HP:0000848)2.21478115
81Partial agenesis of the corpus callosum (HP:0001338)2.19014825
82Truncal ataxia (HP:0002078)2.16764987
83Neoplasm of the adrenal cortex (HP:0100641)2.15574955
84Overriding aorta (HP:0002623)2.14978029
85Scanning speech (HP:0002168)2.13216701
86Metaphyseal dysplasia (HP:0100255)2.12215579
87Spastic tetraparesis (HP:0001285)2.08006552
88Mutism (HP:0002300)2.07712243
89Hypoglycemic seizures (HP:0002173)2.06792182
90Bowel incontinence (HP:0002607)2.06681774
91Optic nerve hypoplasia (HP:0000609)2.04084611
92Rib fusion (HP:0000902)2.04041510
93CNS hypomyelination (HP:0003429)2.03728906
94Slow saccadic eye movements (HP:0000514)2.03205689
95Aplasia/Hypoplasia of the sternum (HP:0006714)2.03072801
96Neoplasm of the peripheral nervous system (HP:0100007)2.01180734
97Anomalous pulmonary venous return (HP:0010772)1.98596072
98Cupped ear (HP:0000378)1.97375182
99Synostosis of carpal bones (HP:0005048)1.97223235
100Type II lissencephaly (HP:0007260)1.96981195
101Abnormal large intestine physiology (HP:0012700)1.96674363
102Megalocornea (HP:0000485)1.96031537
103Urethral obstruction (HP:0000796)1.95273066
104Large earlobe (HP:0009748)1.94732236
105Urinary urgency (HP:0000012)1.93562764
106Anophthalmia (HP:0000528)1.93262167
107Action tremor (HP:0002345)1.92522930
108Hypomagnesemia (HP:0002917)1.92231354
109Ankyloglossia (HP:0010296)1.91882831
110Stereotypic behavior (HP:0000733)1.91453055
111Maternal diabetes (HP:0009800)1.91054375
112Clumsiness (HP:0002312)1.89043408
113Rigidity (HP:0002063)1.88592071
114Intellectual disability, moderate (HP:0002342)1.87541140
115Anterior segment dysgenesis (HP:0007700)1.86483992
116Depression (HP:0000716)1.84663511
117Abnormality of the parathyroid morphology (HP:0011766)1.84265643
118Partial duplication of thumb phalanx (HP:0009944)1.83987449
119Short palpebral fissure (HP:0012745)1.82809216
120Laryngomalacia (HP:0001601)1.82641177
121Mitral regurgitation (HP:0001653)1.81872999
122Morphological abnormality of the pyramidal tract (HP:0002062)1.81622843
123Hypercalcemia (HP:0003072)1.81286585
124Renovascular hypertension (HP:0100817)1.80893387
125Obsessive-compulsive behavior (HP:0000722)1.80796929
126Hyperaldosteronism (HP:0000859)1.78510490
127Absent speech (HP:0001344)1.78435141
128Anxiety (HP:0000739)1.78127148
129Abnormality of the middle phalanges of the toes (HP:0010183)1.75758562
130Abnormality of the diencephalon (HP:0010662)1.74540944
131Progressive cerebellar ataxia (HP:0002073)1.74310961
132Postural instability (HP:0002172)1.73477532
133Clonus (HP:0002169)1.72306245
134Turricephaly (HP:0000262)1.72073248
135Diminished motivation (HP:0000745)1.71568446
136Aqueductal stenosis (HP:0002410)1.71426610
137Apathy (HP:0000741)1.71349721
138Paraparesis (HP:0002385)1.70331097
139Torticollis (HP:0000473)1.69781545
140Abnormality of the pulmonary veins (HP:0011718)1.69679448
141Abnormality of magnesium homeostasis (HP:0004921)1.69588976
142Urinary bladder sphincter dysfunction (HP:0002839)1.69195646
143Meningocele (HP:0002435)1.69006150
144Hypoplasia of the corpus callosum (HP:0002079)1.68861086
145Anosmia (HP:0000458)1.68764137
146Urinary incontinence (HP:0000020)1.68184765
147Missing ribs (HP:0000921)1.67616797
148Myelomeningocele (HP:0002475)1.66704695
149Epiphyseal dysplasia (HP:0002656)1.65897219
150Hammertoe (HP:0001765)1.63982856
151Congenital ichthyosiform erythroderma (HP:0007431)1.62636694
152Infantile muscular hypotonia (HP:0008947)1.62025141
153Pachygyria (HP:0001302)1.59507558
154Limb dystonia (HP:0002451)1.58335423
155Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.57930658
156Oligodactyly (HP:0012165)1.57866942
157Generalized myoclonic seizures (HP:0002123)1.57645497
158Mixed hearing impairment (HP:0000410)1.57398281
159Cerebral hemorrhage (HP:0001342)1.56795072
160Dysdiadochokinesis (HP:0002075)1.56422876
161Atonic seizures (HP:0010819)1.56012085

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.98045238
2OXSR13.44354569
3TNIK3.13510719
4TYRO32.84930633
5TNK22.69795692
6EPHB12.60675790
7ICK2.57629982
8LIMK12.53281590
9CDK192.39781543
10PKN12.33819470
11CASK2.25240884
12PRPF4B2.17136113
13BCR2.01580151
14ERBB41.94623305
15UHMK11.94603430
16CSNK1G31.94036611
17NEK61.92687491
18PAK61.91230833
19TESK21.90932880
20NTRK11.88969208
21MARK11.85140728
22FGFR21.84316232
23MET1.83457205
24CSNK1A1L1.82743279
25ROCK21.70225970
26PBK1.69013855
27WNK41.62180942
28CAMKK11.54603100
29CSNK1G21.53722754
30MAPKAPK51.49740717
31FGR1.47325471
32NTRK21.46841963
33CSNK1G11.44737795
34IRAK21.43576163
35SGK21.39006034
36EPHA41.30991273
37MINK11.30111563
38PAK31.25486497
39WNK11.24264449
40MAP3K91.23322475
41CDK141.17190260
42SGK31.15727744
43STK38L1.15714767
44RIPK11.15502332
45CAMK2B1.14688315
46PHKG11.14085944
47PHKG21.14085944
48IRAK11.13440521
49PDGFRB1.10412074
50SIK21.09235585
51PINK11.09089723
52CDK151.08247261
53PNCK1.07557379
54FES1.05523077
55CDK181.01422774
56CDK11A1.01278947
57KSR20.96741006
58CAMK2D0.94395481
59BMX0.93774794
60CLK10.90187624
61MAPK130.89992224
62CDK50.88222708
63DYRK20.87997869
64KSR10.85648444
65MKNK10.84685846
66SGK10.84572231
67PRKCG0.84396845
68DAPK20.82466648
69MUSK0.81888364
70PRKD30.80955801
71DYRK1B0.79475013
72CAMK2G0.76288298
73SGK2230.73893052
74SGK4940.73893052
75PDGFRA0.72241395
76CAMK10.71031480
77CAMK2A0.70827601
78MAPK120.70259379
79ERBB20.69778335
80PRKD10.66871765
81CAMK40.65904273
82MAP3K130.60968954
83CAMK1D0.60399265
84ROCK10.59015706
85CSNK1D0.58982703
86NTRK30.58965824
87PRKCZ0.58965548
88DYRK1A0.58926791
89PRKCH0.58509873
90PRKCQ0.58064074
91RAF10.57233144
92FYN0.57011072
93LMTK20.55273283
94ILK0.54738919
95TESK10.53704483
96DMPK0.53528022
97MKNK20.50612978
98STK380.49118148
99MOS0.48246092
100ALK0.47771436
101PTK20.47652206
102PRKCE0.45967084
103MAPK150.45786390
104RET0.44789070
105PLK20.44647045
106DDR20.43865665
107BRSK10.43802357
108GSK3A0.43511556
109MARK20.41886482
110CAMKK20.41162778
111RPS6KA30.40544569
112STK110.40067245
113ARAF0.38527948
114MAP2K70.36742642
115PIK3CA0.36291667
116MST40.34386139
117LRRK20.33437810
118RPS6KB10.32982928
119MAP3K10.31881733
120PAK20.31439316
121MAP2K10.31294189
122MAP2K40.31159337
123MAP3K40.30916706
124INSR0.30880742
125CSNK1A10.30170118
126PRKG10.29797934
127PAK10.29582409
128PRKACB0.29148154
129SRC0.29023836
130CAMK1G0.25407821
131PDPK10.25038283
132MAPK100.24679697
133CSK0.24081601

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.71336775
2Steroid biosynthesis_Homo sapiens_hsa001004.14479412
3Fatty acid elongation_Homo sapiens_hsa000623.40491978
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.37352272
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.22394565
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.03902280
7Nitrogen metabolism_Homo sapiens_hsa009102.52416517
8Axon guidance_Homo sapiens_hsa043602.44362875
9Ether lipid metabolism_Homo sapiens_hsa005652.22383524
10Insulin secretion_Homo sapiens_hsa049112.14498305
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10584778
12Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.83136114
13Vitamin B6 metabolism_Homo sapiens_hsa007501.73835859
14Sulfur metabolism_Homo sapiens_hsa009201.62739075
15Glutamatergic synapse_Homo sapiens_hsa047241.60651026
16Renal cell carcinoma_Homo sapiens_hsa052111.57535968
17GABAergic synapse_Homo sapiens_hsa047271.53190652
18Butanoate metabolism_Homo sapiens_hsa006501.39319571
19Bile secretion_Homo sapiens_hsa049761.30442351
20Long-term depression_Homo sapiens_hsa047301.29451960
21VEGF signaling pathway_Homo sapiens_hsa043701.28192856
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28123227
23Sphingolipid metabolism_Homo sapiens_hsa006001.27299565
24Dorso-ventral axis formation_Homo sapiens_hsa043201.26750534
25Endometrial cancer_Homo sapiens_hsa052131.25976844
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25860885
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.22548303
28Tight junction_Homo sapiens_hsa045301.21676537
29Serotonergic synapse_Homo sapiens_hsa047261.21329920
30Phospholipase D signaling pathway_Homo sapiens_hsa040721.20460341
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19247830
32Hedgehog signaling pathway_Homo sapiens_hsa043401.16109053
33ErbB signaling pathway_Homo sapiens_hsa040121.15853633
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15736085
35Gap junction_Homo sapiens_hsa045401.13458162
36Morphine addiction_Homo sapiens_hsa050321.10888227
37Fatty acid metabolism_Homo sapiens_hsa012121.09723159
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08556952
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.08415146
40Sphingolipid signaling pathway_Homo sapiens_hsa040711.05834911
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04471682
42Circadian entrainment_Homo sapiens_hsa047131.02660045
43Oxidative phosphorylation_Homo sapiens_hsa001901.02264510
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.01146408
45Glioma_Homo sapiens_hsa052140.98944910
46Basal cell carcinoma_Homo sapiens_hsa052170.95625157
47Nicotine addiction_Homo sapiens_hsa050330.95616191
48Cholinergic synapse_Homo sapiens_hsa047250.95496993
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95419325
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93437151
51Olfactory transduction_Homo sapiens_hsa047400.93290856
52Cocaine addiction_Homo sapiens_hsa050300.90661474
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90631254
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89699875
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89516404
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89472706
57Dopaminergic synapse_Homo sapiens_hsa047280.89444812
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89025452
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88925746
60Vibrio cholerae infection_Homo sapiens_hsa051100.88662690
61Arginine and proline metabolism_Homo sapiens_hsa003300.88109605
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87426699
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86211480
64Endocytosis_Homo sapiens_hsa041440.85275115
65beta-Alanine metabolism_Homo sapiens_hsa004100.83557031
66Gastric acid secretion_Homo sapiens_hsa049710.83330944
67Pancreatic secretion_Homo sapiens_hsa049720.83289770
68Ras signaling pathway_Homo sapiens_hsa040140.83177633
69Prion diseases_Homo sapiens_hsa050200.82896813
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82530911
71Fatty acid biosynthesis_Homo sapiens_hsa000610.82140348
72Taste transduction_Homo sapiens_hsa047420.80704827
73Synaptic vesicle cycle_Homo sapiens_hsa047210.79632308
74Parkinsons disease_Homo sapiens_hsa050120.78923464
75Non-small cell lung cancer_Homo sapiens_hsa052230.78371510
76Salivary secretion_Homo sapiens_hsa049700.78314191
77Choline metabolism in cancer_Homo sapiens_hsa052310.76102807
78Colorectal cancer_Homo sapiens_hsa052100.75123189
79Thyroid hormone synthesis_Homo sapiens_hsa049180.74317716
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74014678
81Hippo signaling pathway_Homo sapiens_hsa043900.72477272
82Alzheimers disease_Homo sapiens_hsa050100.70754722
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70576625
84Renin secretion_Homo sapiens_hsa049240.67514901
85Wnt signaling pathway_Homo sapiens_hsa043100.67457972
86mTOR signaling pathway_Homo sapiens_hsa041500.67300400
87Melanogenesis_Homo sapiens_hsa049160.66156440
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63640863
89Chronic myeloid leukemia_Homo sapiens_hsa052200.63624944
90Notch signaling pathway_Homo sapiens_hsa043300.61511086
91Collecting duct acid secretion_Homo sapiens_hsa049660.61485660
92Oxytocin signaling pathway_Homo sapiens_hsa049210.61252724
93Prolactin signaling pathway_Homo sapiens_hsa049170.59945848
94MicroRNAs in cancer_Homo sapiens_hsa052060.59613688
95Cardiac muscle contraction_Homo sapiens_hsa042600.58176516
96Linoleic acid metabolism_Homo sapiens_hsa005910.57460131
97PPAR signaling pathway_Homo sapiens_hsa033200.55190286
98Amphetamine addiction_Homo sapiens_hsa050310.54962072
99Circadian rhythm_Homo sapiens_hsa047100.53021568
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.52034385
101cAMP signaling pathway_Homo sapiens_hsa040240.51493682
102AMPK signaling pathway_Homo sapiens_hsa041520.51316269
103Long-term potentiation_Homo sapiens_hsa047200.51152391
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50434725
105Alcoholism_Homo sapiens_hsa050340.50422153
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49858719
107Protein export_Homo sapiens_hsa030600.48092016
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47476296
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47405774
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47393818
111GnRH signaling pathway_Homo sapiens_hsa049120.46960851
112Estrogen signaling pathway_Homo sapiens_hsa049150.46935463
113ECM-receptor interaction_Homo sapiens_hsa045120.46410994
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46011427
115Ovarian steroidogenesis_Homo sapiens_hsa049130.45843554
116Inositol phosphate metabolism_Homo sapiens_hsa005620.45539047
117Histidine metabolism_Homo sapiens_hsa003400.45024446
118Focal adhesion_Homo sapiens_hsa045100.43083247
119Huntingtons disease_Homo sapiens_hsa050160.42856191
120Prostate cancer_Homo sapiens_hsa052150.42618502
121Dilated cardiomyopathy_Homo sapiens_hsa054140.41880725
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40873607
123Pancreatic cancer_Homo sapiens_hsa052120.40424592
124MAPK signaling pathway_Homo sapiens_hsa040100.40387580
125Propanoate metabolism_Homo sapiens_hsa006400.40051138
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39875489
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39299020
128Melanoma_Homo sapiens_hsa052180.39222899
129Arginine biosynthesis_Homo sapiens_hsa002200.38976010
130Rap1 signaling pathway_Homo sapiens_hsa040150.36641042
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35318496
132Calcium signaling pathway_Homo sapiens_hsa040200.34921274

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