OLR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.66711450
2detection of molecule of bacterial origin (GO:0032490)5.96115043
3positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.79277719
4modulation by symbiont of host immune response (GO:0052553)5.68968973
5positive regulation by symbiont of host defense response (GO:0052509)5.68968973
6modulation by symbiont of host defense response (GO:0052031)5.68968973
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.68968973
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.68968973
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.68968973
10macrophage activation involved in immune response (GO:0002281)5.36160882
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.29210544
12regulation of vitamin metabolic process (GO:0030656)5.18245806
13response to peptidoglycan (GO:0032494)5.12540973
14neutrophil activation involved in immune response (GO:0002283)4.69991855
15regulation of heat generation (GO:0031650)4.60395736
16positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.55782983
17superoxide anion generation (GO:0042554)4.45215280
18lipopolysaccharide-mediated signaling pathway (GO:0031663)4.42141918
19hydrogen peroxide biosynthetic process (GO:0050665)4.32628470
20positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.30001808
21regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.22671219
22detection of external biotic stimulus (GO:0098581)4.14595177
23respiratory burst (GO:0045730)4.13823551
24response to host immune response (GO:0052572)4.10814734
25response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.10814734
26negative regulation of growth of symbiont in host (GO:0044130)4.10744583
27negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.10744583
28modulation of growth of symbiont involved in interaction with host (GO:0044144)4.10744583
29regulation of growth of symbiont in host (GO:0044126)4.10744583
30reactive oxygen species biosynthetic process (GO:1903409)4.07473888
31production of molecular mediator involved in inflammatory response (GO:0002532)3.97250259
32positive regulation of chemokine biosynthetic process (GO:0045080)3.92626262
33regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.91442987
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.90330954
35glycosphingolipid catabolic process (GO:0046479)3.89318114
36positive regulation of macrophage cytokine production (GO:0060907)3.86946427
37monocyte chemotaxis (GO:0002548)3.85894125
38regulation of vascular endothelial growth factor production (GO:0010574)3.80428824
39regulation of prostaglandin secretion (GO:0032306)3.80236049
40positive regulation of prostaglandin secretion (GO:0032308)3.79872383
41positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.79077942
42macrophage activation (GO:0042116)3.78243569
43positive regulation of toll-like receptor signaling pathway (GO:0034123)3.77693404
44T-helper 1 type immune response (GO:0042088)3.76166252
45negative regulation of interleukin-17 production (GO:0032700)3.73903814
46positive regulation of interferon-alpha production (GO:0032727)3.73588722
47positive regulation of respiratory burst (GO:0060267)3.69714910
48regulation of membrane protein ectodomain proteolysis (GO:0051043)3.69308509
49granulocyte activation (GO:0036230)3.68998052
50regulation of podosome assembly (GO:0071801)3.68296299
51response to host (GO:0075136)3.66813135
52response to host defenses (GO:0052200)3.66813135
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.66813135
54regulation of interferon-alpha production (GO:0032647)3.62754537
55positive regulation vascular endothelial growth factor production (GO:0010575)3.62328938
56detection of biotic stimulus (GO:0009595)3.60869034
57regulation of interleukin-2 biosynthetic process (GO:0045076)3.60622308
58positive regulation of heat generation (GO:0031652)3.58005209
59purine ribonucleotide transport (GO:0015868)3.57757191
60oligosaccharide catabolic process (GO:0009313)3.57497970
61adenine nucleotide transport (GO:0051503)3.56593956
62positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.55262081
63neutrophil activation (GO:0042119)3.51765858
64leukocyte aggregation (GO:0070486)3.49673169
65myeloid cell activation involved in immune response (GO:0002275)3.48960445
66glycolipid catabolic process (GO:0019377)3.46234819
67positive regulation of acute inflammatory response (GO:0002675)3.45460625
68positive regulation of monocyte chemotaxis (GO:0090026)3.43068199
69regulation of NF-kappaB import into nucleus (GO:0042345)3.41479945
70regulation of macrophage cytokine production (GO:0010935)3.40640567
71microglial cell activation (GO:0001774)3.39561705
72regulation of mononuclear cell migration (GO:0071675)3.39071603
73regulation of chemokine biosynthetic process (GO:0045073)3.36880203
74cellular response to thyroid hormone stimulus (GO:0097067)3.34976348
75regulation of fever generation (GO:0031620)3.34752998
76positive regulation of nitric oxide biosynthetic process (GO:0045429)3.32979576
77regulation of T-helper 1 cell differentiation (GO:0045625)3.30935356
78negative regulation of interleukin-12 production (GO:0032695)3.28068238
79positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.26895939
80response to muramyl dipeptide (GO:0032495)3.26328809
81positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.25895632
82regulation of interferon-beta biosynthetic process (GO:0045357)3.17442638
83positive regulation of tumor necrosis factor production (GO:0032760)3.17064427
84positive regulation of chemokine production (GO:0032722)3.16767003
85NIK/NF-kappaB signaling (GO:0038061)3.15567964
86germinal center formation (GO:0002467)3.15554905
87cellular extravasation (GO:0045123)3.15108924
88regulation of nitric oxide biosynthetic process (GO:0045428)3.14862134
89positive regulation of mast cell activation involved in immune response (GO:0033008)3.13196394
90positive regulation of mast cell degranulation (GO:0043306)3.13196394
91eosinophil chemotaxis (GO:0048245)3.12464281
92regulation of interleukin-6 biosynthetic process (GO:0045408)3.11827058
93regulation of monocyte chemotaxis (GO:0090025)3.10953784
94immunoglobulin mediated immune response (GO:0016064)3.09762872
95neutrophil chemotaxis (GO:0030593)3.08959501
96positive regulation of interleukin-12 production (GO:0032735)3.08726075
97regulation of cytokine secretion involved in immune response (GO:0002739)3.08200008
98regulation of macrophage chemotaxis (GO:0010758)3.08005269
99ceramide catabolic process (GO:0046514)3.07722566
100negative regulation of myeloid cell apoptotic process (GO:0033033)3.07594085
101positive regulation of cytokine biosynthetic process (GO:0042108)3.05231336
102regulation of T-helper 2 cell differentiation (GO:0045628)3.04816794
103regulation of interleukin-12 biosynthetic process (GO:0045075)3.03222374
104positive regulation of interleukin-6 production (GO:0032755)3.01848544
105neutrophil migration (GO:1990266)3.00579452
106positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.99830743
107response to protozoan (GO:0001562)2.99762725
108regulation of integrin activation (GO:0033623)2.99732981
109myeloid dendritic cell differentiation (GO:0043011)2.98371018
110low-density lipoprotein particle clearance (GO:0034383)2.97713082
111negative regulation of cytokine production involved in immune response (GO:0002719)2.97373969
112cellular response to arsenic-containing substance (GO:0071243)2.97114958
113regulation of mast cell degranulation (GO:0043304)2.97023248
114positive regulation of mast cell activation (GO:0033005)2.95911510
115positive regulation of gamma-delta T cell activation (GO:0046645)2.95435904
116leukocyte migration involved in inflammatory response (GO:0002523)2.94750309
117purine nucleotide transport (GO:0015865)2.94748677
118positive regulation of interleukin-10 production (GO:0032733)2.94010431
119cellular response to ethanol (GO:0071361)2.93078664
120regulation of lymphocyte chemotaxis (GO:1901623)2.91612367
121positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91534005
122positive regulation of interferon-beta production (GO:0032728)2.91150925
123eosinophil migration (GO:0072677)2.90213095
124regulation of cholesterol storage (GO:0010885)2.90033358
125positive regulation of interleukin-2 production (GO:0032743)2.89695998
126positive regulation of NF-kappaB import into nucleus (GO:0042346)2.89224020
127negative regulation of interleukin-1 beta production (GO:0032691)2.88621526
128granulocyte chemotaxis (GO:0071621)2.87901317
129positive regulation of type 2 immune response (GO:0002830)2.86852551
130myeloid leukocyte activation (GO:0002274)2.86815025
131neutrophil mediated immunity (GO:0002446)2.86533195
132regulation of chronic inflammatory response (GO:0002676)2.85412360
133positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.84912048
134positive regulation of transcription factor import into nucleus (GO:0042993)2.83759399
135regulation of interleukin-17 production (GO:0032660)2.83536220
136opsonization (GO:0008228)2.82000816
137regulation of interleukin-12 production (GO:0032655)2.79462708
138cellular response to lipopolysaccharide (GO:0071222)2.79324005
139positive regulation of cellular amide metabolic process (GO:0034250)2.79289071
140myeloid dendritic cell activation (GO:0001773)2.78782014
141negative regulation of lipid storage (GO:0010888)2.78603494
142regulation of interleukin-6 production (GO:0032675)2.78532772
143cellular response to molecule of bacterial origin (GO:0071219)2.77986217
144I-kappaB phosphorylation (GO:0007252)2.77125156
145regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.76476552
146regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.76062090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.05600510
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.17066311
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.23498569
4Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.94840616
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.92638291
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.92047828
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.78545625
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.38405768
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.22048127
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20327762
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.10313034
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.06155963
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95619309
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69532331
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48267044
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.40688788
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06830655
18GATA1_22025678_ChIP-Seq_K562_Human1.97319065
19PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.96444202
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93727067
21* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.92416926
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88154256
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87164187
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.82079373
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81678097
26PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.81233707
27VDR_24787735_ChIP-Seq_THP-1_Human1.80323250
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73513170
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69995281
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69828910
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66949554
32* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61870340
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.59960556
34SCL_19346495_ChIP-Seq_HPC-7_Human1.56596556
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54535213
36RUNX_20019798_ChIP-Seq_JUKART_Human1.49316166
37NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.47098653
38PU_27001747_Chip-Seq_BMDM_Mouse1.46680515
39SPI1_23547873_ChIP-Seq_NB4_Human1.44800634
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44355805
41CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42178503
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39826849
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39826849
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37669599
45IGF1R_20145208_ChIP-Seq_DFB_Human1.36512511
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.35819288
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.35646867
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35502105
49* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34059073
50VDR_21846776_ChIP-Seq_THP-1_Human1.33697198
51SPI1_23127762_ChIP-Seq_K562_Human1.30650907
52TFEB_21752829_ChIP-Seq_HELA_Human1.28309208
53VDR_24763502_ChIP-Seq_THP-1_Human1.26919196
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23707883
55MYB_26560356_Chip-Seq_TH2_Human1.23381720
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20680131
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20406693
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19307110
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17856838
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14802626
61CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10007648
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.08439203
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07484304
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07135781
65JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06871128
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06840913
67CJUN_26792858_Chip-Seq_BT549_Human1.06422903
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04911676
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.04592904
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02409910
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02058416
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01773707
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01264517
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00780917
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99430099
76SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98937228
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98295554
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98221696
79GATA1_19941826_ChIP-Seq_K562_Human0.96033396
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95759074
81SOX2_20726797_ChIP-Seq_SW620_Human0.95731154
82RUNX1_22412390_ChIP-Seq_EML_Mouse0.95645259
83* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94184411
84ELK3_25401928_ChIP-Seq_HUVEC_Human0.93617426
85GATA3_26560356_Chip-Seq_TH2_Human0.92722195
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91931880
87* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91872194
88TP53_18474530_ChIP-ChIP_U2OS_Human0.91373625
89IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88806035
90MAF_26560356_Chip-Seq_TH1_Human0.87430854
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87113815
92* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86668866
93* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86668866
94LXR_22158963_ChIP-Seq_LIVER_Mouse0.86169426
95RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86047636
96TCF7_22412390_ChIP-Seq_EML_Mouse0.85872698
97MYB_26560356_Chip-Seq_TH1_Human0.85348422
98PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85277603
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85044580
100KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84231247
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83618570
102STAT1_20625510_ChIP-Seq_HELA_Human0.83597564
103EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83364549
104ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83193552
105PU1_27457419_Chip-Seq_LIVER_Mouse0.83086509
106P53_22387025_ChIP-Seq_ESCs_Mouse0.81230254
107PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80321292
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80286373
109ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80282621
110SUZ12_18555785_Chip-Seq_ESCs_Mouse0.79711959
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.79279718
112SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79135218
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78750212
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78260701
115CMYC_18555785_Chip-Seq_ESCs_Mouse0.78256475
116PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78042877
117ZFP57_27257070_Chip-Seq_ESCs_Mouse0.77386676
118STAT3_18555785_Chip-Seq_ESCs_Mouse0.77228847
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77172106
120CLOCK_20551151_ChIP-Seq_293T_Human0.76113162
121SOX2_18555785_Chip-Seq_ESCs_Mouse0.75964973
122SMAD1_18555785_Chip-Seq_ESCs_Mouse0.75956879
123PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.74119648
124NMYC_18555785_Chip-Seq_ESCs_Mouse0.73107694
125GATA2_22383799_ChIP-Seq_G1ME_Mouse0.72803930
126GATA3_27048872_Chip-Seq_THYMUS_Human0.72649533
127GATA2_19941826_ChIP-Seq_K562_Human0.72120765
128UBF1/2_26484160_Chip-Seq_HMECs_Human0.71321793
129UTX_26944678_Chip-Seq_JUKART_Human0.71179403
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.70786010
131* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70098759

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.21776559
2MP0009785_altered_susceptibility_to3.99140963
3MP0003436_decreased_susceptibility_to3.98037844
4MP0003303_peritoneal_inflammation3.67991780
5MP0002148_abnormal_hypersensitivity_rea3.66639193
6MP0002419_abnormal_innate_immunity3.49291515
7MP0003724_increased_susceptibility_to3.48202030
8MP0006082_CNS_inflammation3.14770951
9MP0005000_abnormal_immune_tolerance3.02435629
10MP0004510_myositis3.00109301
11MP0005025_abnormal_response_to2.97178855
12MP0001790_abnormal_immune_system2.67005539
13MP0005387_immune_system_phenotype2.67005539
14MP0002452_abnormal_antigen_presenting2.53878623
15MP0009764_decreased_sensitivity_to2.51805889
16MP0005671_abnormal_response_to2.45346392
17* MP0002723_abnormal_immune_serum2.31629581
18MP0002254_reproductive_system_inflammat2.27056817
19MP0005058_abnormal_lysosome_morphology2.21033970
20MP0001533_abnormal_skeleton_physiology2.20991309
21MP0001800_abnormal_humoral_immune2.16211397
22MP0001819_abnormal_immune_cell2.09143826
23MP0005464_abnormal_platelet_physiology2.04238186
24MP0002420_abnormal_adaptive_immunity2.03799761
25MP0003448_altered_tumor_morphology2.01729675
26MP0000685_abnormal_immune_system1.99537297
27MP0003075_altered_response_to1.91442453
28MP0001853_heart_inflammation1.88766357
29MP0001845_abnormal_inflammatory_respons1.84484253
30MP0008438_abnormal_cutaneous_collagen1.80272264
31MP0003656_abnormal_erythrocyte_physiolo1.77690546
32* MP0000343_altered_response_to1.77278512
33MP0005164_abnormal_response_to1.75365033
34MP0002998_abnormal_bone_remodeling1.73576602
35MP0005166_decreased_susceptibility_to1.73270229
36MP0003806_abnormal_nucleotide_metabolis1.72286856
37MP0002405_respiratory_system_inflammati1.71510475
38MP0002139_abnormal_hepatobiliary_system1.70572440
39MP0003136_yellow_coat_color1.66612165
40MP0004947_skin_inflammation1.63159892
41MP0000858_altered_metastatic_potential1.62468549
42* MP0008469_abnormal_protein_level1.52380217
43MP0004782_abnormal_surfactant_physiolog1.51756233
44MP0010155_abnormal_intestine_physiology1.49697426
45MP0003195_calcinosis1.46382840
46MP0003191_abnormal_cellular_cholesterol1.45483978
47MP0009278_abnormal_bone_marrow1.45465014
48MP0002332_abnormal_exercise_endurance1.39709663
49MP0000716_abnormal_immune_system1.36346313
50MP0002102_abnormal_ear_morphology1.35597139
51MP0005451_abnormal_body_composition1.34644836
52MP0004883_abnormal_blood_vessel1.34219846
53MP0003172_abnormal_lysosome_physiology1.32378800
54MP0003566_abnormal_cell_adhesion1.31823180
55MP0002006_tumorigenesis1.29587169
56MP0005167_abnormal_blood-brain_barrier1.26708626
57MP0003828_pulmonary_edema1.22788834
58MP0009333_abnormal_splenocyte_physiolog1.20363474
59MP0010352_gastrointestinal_tract_polyps1.19718193
60MP0000920_abnormal_myelination1.19552346
61MP0005397_hematopoietic_system_phenotyp1.18071164
62MP0001545_abnormal_hematopoietic_system1.18071164
63MP0000767_abnormal_smooth_muscle1.14210685
64MP0000604_amyloidosis1.14136067
65MP0005310_abnormal_salivary_gland1.13874890
66MP0005390_skeleton_phenotype1.11326599
67MP0002398_abnormal_bone_marrow1.10993099
68MP0002877_abnormal_melanocyte_morpholog1.05672494
69MP0002429_abnormal_blood_cell1.04817769
70MP0003690_abnormal_glial_cell1.00687352
71MP0006054_spinal_hemorrhage0.98845017
72MP0000681_abnormal_thyroid_gland0.98337240
73MP0003045_fibrosis0.97986124
74MP0009763_increased_sensitivity_to0.96099223
75MP0003300_gastrointestinal_ulcer0.95971451
76MP0003453_abnormal_keratinocyte_physiol0.94682444
77MP0000372_irregular_coat_pigmentation0.93541266
78MP0000689_abnormal_spleen_morphology0.91702947
79MP0010386_abnormal_urinary_bladder0.88398384
80MP0009765_abnormal_xenobiotic_induced0.88351978
81MP0002933_joint_inflammation0.87673033
82MP0001851_eye_inflammation0.87432954
83MP0002722_abnormal_immune_system0.87171187
84MP0003091_abnormal_cell_migration0.84966518
85MP0003183_abnormal_peptide_metabolism0.83636903
86MP0005165_increased_susceptibility_to0.83462214
87MP0003795_abnormal_bone_structure0.83443224
88* MP0000249_abnormal_blood_vessel0.83440377
89MP0001879_abnormal_lymphatic_vessel0.83430235
90MP0002735_abnormal_chemical_nociception0.83019666
91MP0002168_other_aberrant_phenotype0.82760863
92MP0000015_abnormal_ear_pigmentation0.81464476
93MP0001958_emphysema0.81278215
94MP0008004_abnormal_stomach_pH0.78808630
95MP0003329_amyloid_beta_deposits0.78246746
96MP0001727_abnormal_embryo_implantation0.77845312
97MP0000490_abnormal_crypts_of0.77313125
98MP0000371_diluted_coat_color0.77127229
99MP0003186_abnormal_redox_activity0.77068583
100MP0001663_abnormal_digestive_system0.76768796
101MP0005535_abnormal_body_temperature0.74633255
102MP0004808_abnormal_hematopoietic_stem0.72174728
103MP0005647_abnormal_sex_gland0.71876814
104MP0005076_abnormal_cell_differentiation0.70917578
105MP0005595_abnormal_vascular_smooth0.69266901
106MP0003279_aneurysm0.67671281
107MP0000465_gastrointestinal_hemorrhage0.66212552
108MP0003705_abnormal_hypodermis_morpholog0.64944368
109MP0009840_abnormal_foam_cell0.64029698
110MP0005023_abnormal_wound_healing0.63894894
111MP0005171_absent_coat_pigmentation0.63153167
112MP0008260_abnormal_autophagy0.62723460
113MP0002090_abnormal_vision0.62016035
114MP0002277_abnormal_respiratory_mucosa0.61708319
115MP0008874_decreased_physiological_sensi0.61123262
116MP0002136_abnormal_kidney_physiology0.59057461
117MP0003634_abnormal_glial_cell0.58348523
118MP0001986_abnormal_taste_sensitivity0.57982301
119MP0003633_abnormal_nervous_system0.57276179
120MP0001542_abnormal_bone_strength0.57182899
121MP0008873_increased_physiological_sensi0.56993839
122MP0002138_abnormal_hepatobiliary_system0.55144266
123MP0005584_abnormal_enzyme/coenzyme_acti0.55031501

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.36834940
2Recurrent abscess formation (HP:0002722)6.54065588
3Recurrent gram-negative bacterial infections (HP:0005420)6.37069413
4Recurrent bacterial skin infections (HP:0005406)6.15829723
5Abnormality of macrophages (HP:0004311)5.21943244
6Mediastinal lymphadenopathy (HP:0100721)4.80753212
7Recurrent fungal infections (HP:0002841)4.59667758
8Obstructive lung disease (HP:0006536)4.51485409
9Chronic obstructive pulmonary disease (HP:0006510)4.51485409
10Stomatitis (HP:0010280)4.42037324
11Loss of speech (HP:0002371)4.38483956
12Recurrent skin infections (HP:0001581)4.36159537
13Autoimmune thrombocytopenia (HP:0001973)4.21361077
14Vacuolated lymphocytes (HP:0001922)4.17371815
15Mutism (HP:0002300)4.09706732
16Recurrent cutaneous fungal infections (HP:0011370)4.09538041
17Chronic mucocutaneous candidiasis (HP:0002728)4.09538041
18Systemic lupus erythematosus (HP:0002725)3.93746494
19Gingivitis (HP:0000230)3.92697471
20Neurofibrillary tangles (HP:0002185)3.60497100
21Orchitis (HP:0100796)3.48216706
22Recurrent viral infections (HP:0004429)3.47784512
23Increased neuronal autofluorescent lipopigment (HP:0002074)3.43126274
24Increased cerebral lipofuscin (HP:0011813)3.42997302
25Interstitial pulmonary disease (HP:0006530)3.38394072
26Retrobulbar optic neuritis (HP:0100654)3.36828159
27Optic neuritis (HP:0100653)3.36828159
28Myositis (HP:0100614)3.31730297
29Amyloidosis (HP:0011034)3.30248000
30Vasculitis (HP:0002633)3.09895246
31Basal ganglia calcification (HP:0002135)3.05417951
32Apathy (HP:0000741)3.04933008
33Elevated erythrocyte sedimentation rate (HP:0003565)2.99220814
34Diminished motivation (HP:0000745)2.97029005
35Dysostosis multiplex (HP:0000943)2.96711052
36Agnosia (HP:0010524)2.89982625
37Hematochezia (HP:0002573)2.85845082
38Spondylolisthesis (HP:0003302)2.81068565
39Neuronal loss in central nervous system (HP:0002529)2.79121442
40Prostate neoplasm (HP:0100787)2.78202924
41Nuclear cataract (HP:0100018)2.76805812
42Meningitis (HP:0001287)2.76560284
43Pulmonary infiltrates (HP:0002113)2.70919142
44Abnormality of the vasculature of the conjunctiva (HP:0008054)2.70547819
45Cellulitis (HP:0100658)2.69718409
46Osteomyelitis (HP:0002754)2.67697501
47Purpura (HP:0000979)2.66709557
48Periodontitis (HP:0000704)2.66678790
49Urticaria (HP:0001025)2.63146753
50Petechiae (HP:0000967)2.62538221
51Myocardial infarction (HP:0001658)2.59196902
52Gastrointestinal infarctions (HP:0005244)2.58784813
53Inappropriate behavior (HP:0000719)2.58528991
54Mucopolysacchariduria (HP:0008155)2.58006209
55Urinary glycosaminoglycan excretion (HP:0003541)2.58006209
56Progressive neurologic deterioration (HP:0002344)2.55380981
57Gingival bleeding (HP:0000225)2.53085022
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.53035461
59Abnormality of polysaccharide metabolism (HP:0011012)2.53035461
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.53035461
61Complement deficiency (HP:0004431)2.52513550
62Polyneuropathy (HP:0001271)2.51678273
63Osteolytic defects of the hand bones (HP:0009699)2.47509711
64Osteolytic defects of the phalanges of the hand (HP:0009771)2.47509711
65Increased serum ferritin (HP:0003281)2.47395051
66Gangrene (HP:0100758)2.46243521
67Axonal loss (HP:0003447)2.45922133
68Cerebral inclusion bodies (HP:0100314)2.44942229
69Hemoptysis (HP:0002105)2.42748072
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.41393630
71Abnormality of glycolipid metabolism (HP:0010969)2.41393630
72Abnormality of liposaccharide metabolism (HP:0010968)2.41393630
73Joint hemorrhage (HP:0005261)2.40775826
74Increased IgM level (HP:0003496)2.40486933
75Absent frontal sinuses (HP:0002688)2.40413523
76Keratoconjunctivitis (HP:0001096)2.39773818
77Abnormal delayed hypersensitivity skin test (HP:0002963)2.38356733
78Episodic fever (HP:0001954)2.37665851
79Leukocytosis (HP:0001974)2.35481937
80Recurrent pneumonia (HP:0006532)2.35030952
81Pustule (HP:0200039)2.33988773
82Recurrent lower respiratory tract infections (HP:0002783)2.33893169
83Arterial thrombosis (HP:0004420)2.33292820
84Upper motor neuron abnormality (HP:0002127)2.32803063
85Tetany (HP:0001281)2.31003610
86Hypergammaglobulinemia (HP:0010702)2.28715035
87Abnormality of the periventricular white matter (HP:0002518)2.24692398
88Disinhibition (HP:0000734)2.21613210
89Cheilitis (HP:0100825)2.19847473
90Peritonitis (HP:0002586)2.18901611
91Asymmetric septal hypertrophy (HP:0001670)2.18167650
92Increased CSF protein (HP:0002922)2.17431565
93Porencephaly (HP:0002132)2.16586897
94Nausea (HP:0002018)2.12878854
95Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.12530929
96Abnormality of complement system (HP:0005339)2.11840699
97Retinal atrophy (HP:0001105)2.11795121
98Tetraparesis (HP:0002273)2.11138172
99Panhypogammaglobulinemia (HP:0003139)2.11045238
100Abnormality of T cell physiology (HP:0011840)2.10856850
101Bone pain (HP:0002653)2.10275548
102Menorrhagia (HP:0000132)2.08341352
103Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.06766345
104Arterial tortuosity (HP:0005116)2.06352910
105Glomerulonephritis (HP:0000099)2.06065975
106Global brain atrophy (HP:0002283)2.04666106
107Esophageal neoplasm (HP:0100751)2.03654762
108Neoplasm of head and neck (HP:0012288)2.03654762
109Personality changes (HP:0000751)2.00255004
110Pathologic fracture (HP:0002756)2.00178409
111Aplasia/Hypoplasia of the fovea (HP:0008060)1.98582983
112Hypoplasia of the fovea (HP:0007750)1.98582983
113Hepatosplenomegaly (HP:0001433)1.98331497
114Joint swelling (HP:0001386)1.97985693
115Pulmonary artery stenosis (HP:0004415)1.97816145
116Abnormality of iron homeostasis (HP:0011031)1.97537669
117Metaphyseal irregularity (HP:0003025)1.96392426
118Keratoconjunctivitis sicca (HP:0001097)1.95326380
119Delayed closure of the anterior fontanelle (HP:0001476)1.93001601
120Restrictive lung disease (HP:0002091)1.92941807
121Supranuclear gaze palsy (HP:0000605)1.92463283
122Dementia (HP:0000726)1.92362477
123Progressive visual loss (HP:0000529)1.89874194
124Memory impairment (HP:0002354)1.88748109
125Abnormality of the prostate (HP:0008775)1.88745494
126Aortic dissection (HP:0002647)1.87585600
127Anorexia (HP:0002039)1.85639446
128Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.84990007
129Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.83883787
130Nephritis (HP:0000123)1.83120608
131Vascular tortuosity (HP:0004948)1.82020632
132Vertigo (HP:0002321)1.81801011
133Eosinophilia (HP:0001880)1.81100821
134Fused cervical vertebrae (HP:0002949)1.80632185
135Peripheral demyelination (HP:0011096)1.79884628
136Abnormality of the pericardium (HP:0001697)1.79070113
137Prolonged neonatal jaundice (HP:0006579)1.78907291
138Abnormality of T cells (HP:0002843)1.77783474
139Vertebral compression fractures (HP:0002953)1.76824131
140Arthralgia (HP:0002829)1.76584846
141Abnormality of the endocardium (HP:0004306)1.76201065
142Conjunctival telangiectasia (HP:0000524)1.75296755
143Thick nail (HP:0001805)1.72985103

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.56019647
2MAP3K144.24484772
3RIPK43.50042970
4BLK3.37728776
5IRAK43.34785757
6TBK13.27170472
7MST42.98180677
8DDR22.75020024
9PBK2.73992296
10TXK2.45125200
11STK242.32909193
12IKBKE2.27312241
13IKBKB2.22496109
14MAP4K12.17573998
15JAK32.13388760
16ERN12.07095355
17PDK22.01683895
18PIM21.99317334
19TGFBR21.93895970
20PRPF4B1.82040070
21MST1R1.73278758
22KIT1.72067084
23STK38L1.64501888
24TYK21.59350250
25EPHB11.54717830
26JAK11.54636474
27RPS6KA41.46007032
28TAOK21.43152334
29NTRK11.39967793
30MOS1.39151885
31BMX1.38266856
32PIM11.37001385
33ACVR1B1.35219719
34CDC42BPA1.33999725
35CHUK1.33008665
36TAOK11.31472669
37MAP3K131.31100142
38TAOK31.27723630
39TRPM71.21874961
40STK41.21762239
41EPHA31.20200955
42NEK91.16120913
43SYK1.15942281
44ABL21.15468560
45CSK1.15264782
46LATS21.13881006
47ADRBK21.13692237
48HCK1.12349031
49NME21.11427721
50ZAP701.08860110
51EIF2AK21.08579567
52OBSCN1.07596229
53BTK1.00419705
54MARK30.99247101
55IRAK10.95109069
56TEC0.94892591
57LYN0.94004115
58TTN0.92639583
59JAK20.90201962
60CLK10.88741777
61BMPR20.88368815
62SIK30.82973751
63GRK70.79086651
64LCK0.79045502
65ERBB30.77892611
66CAMKK20.74170157
67IRAK20.72001089
68STK100.70748276
69PAK40.69272191
70FGR0.67968699
71CAMK1D0.67610559
72CDK60.65405655
73ABL10.65345369
74ARAF0.65276696
75EGFR0.64468314
76STK30.63590439
77PIK3CG0.63473832
78MATK0.60932577
79MAP3K120.60657223
80PRKCD0.60364928
81FGFR30.59244267
82MAP3K50.57383854
83YES10.55495853
84TYRO30.54821108
85FES0.53093459
86PDGFRA0.50254498
87MAP3K110.49614012
88MAP3K10.49172890
89RPS6KA60.46328289
90RIPK10.46252525
91DAPK20.46034268
92DAPK30.44479516
93ERBB40.44349682
94MYLK0.42744514
95MAP2K30.42059583
96MAP3K20.41925526
97PDGFRB0.41307666
98ITK0.40206309
99MAP3K30.38615099
100PDPK10.38107804
101CSF1R0.37825294
102CAMKK10.36913150
103MET0.36813880
104NLK0.36313640
105PDK10.35946510
106RPS6KA50.32523894
107PRKCQ0.31659986
108KSR20.30234041
109NUAK10.27844815
110RPS6KA20.26813530
111PTK60.26697579
112MAPKAPK20.26477211
113NEK60.26144700
114MAP2K60.25862900
115INSR0.25391624
116TESK20.25290803
117LRRK20.25089089
118MAPK40.24708620
119FYN0.23287870
120GSK3A0.22843811
121EPHB20.21954476
122SRC0.21913837
123SGK10.21760146
124RPS6KC10.18486349
125RPS6KL10.18486349
126CAMK2G0.18014034
127KSR10.17563320
128CSNK1A1L0.16948351
129FER0.16614191
130IGF1R0.16404331
131TESK10.15768044
132MAP3K90.15600787
133PRKAA20.15245198
134PKN10.14838661

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.56395420
2Graft-versus-host disease_Homo sapiens_hsa053323.18297299
3Staphylococcus aureus infection_Homo sapiens_hsa051502.87421804
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.76956268
5Rheumatoid arthritis_Homo sapiens_hsa053232.71261577
6Tuberculosis_Homo sapiens_hsa051522.56191294
7Malaria_Homo sapiens_hsa051442.55878186
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.55654898
9Legionellosis_Homo sapiens_hsa051342.54897061
10Allograft rejection_Homo sapiens_hsa053302.43153418
11Pertussis_Homo sapiens_hsa051332.36556732
12Osteoclast differentiation_Homo sapiens_hsa043802.30286843
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.14210010
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11916773
15* Phagosome_Homo sapiens_hsa041452.08089791
16Type I diabetes mellitus_Homo sapiens_hsa049402.05775289
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.96056969
18Hematopoietic cell lineage_Homo sapiens_hsa046401.90218337
19Salmonella infection_Homo sapiens_hsa051321.86164553
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86068704
21Lysosome_Homo sapiens_hsa041421.85194772
22TNF signaling pathway_Homo sapiens_hsa046681.84846599
23Asthma_Homo sapiens_hsa053101.84369381
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77587754
25Measles_Homo sapiens_hsa051621.69992865
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.57731609
27African trypanosomiasis_Homo sapiens_hsa051431.56715576
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.52345040
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.47243664
30Toxoplasmosis_Homo sapiens_hsa051451.39588192
31Influenza A_Homo sapiens_hsa051641.38229024
32Other glycan degradation_Homo sapiens_hsa005111.35812288
33Amoebiasis_Homo sapiens_hsa051461.29590354
34Herpes simplex infection_Homo sapiens_hsa051681.27586841
35Apoptosis_Homo sapiens_hsa042101.27478541
36Chemokine signaling pathway_Homo sapiens_hsa040621.27394885
37Autoimmune thyroid disease_Homo sapiens_hsa053201.27235512
38Complement and coagulation cascades_Homo sapiens_hsa046101.26644667
39B cell receptor signaling pathway_Homo sapiens_hsa046621.24700095
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17173816
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16398075
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14541739
43Shigellosis_Homo sapiens_hsa051311.13116106
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05444870
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02610089
46Hepatitis B_Homo sapiens_hsa051611.00440848
47Bladder cancer_Homo sapiens_hsa052190.99758585
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.99361387
49Collecting duct acid secretion_Homo sapiens_hsa049660.97848270
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97815356
51Antigen processing and presentation_Homo sapiens_hsa046120.90577652
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.84159543
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83726462
54Viral myocarditis_Homo sapiens_hsa054160.82838528
55Primary immunodeficiency_Homo sapiens_hsa053400.80945389
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79603315
57Chronic myeloid leukemia_Homo sapiens_hsa052200.72976094
58Hepatitis C_Homo sapiens_hsa051600.71861322
59Prion diseases_Homo sapiens_hsa050200.68727671
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64279441
61Sphingolipid metabolism_Homo sapiens_hsa006000.63278002
62T cell receptor signaling pathway_Homo sapiens_hsa046600.62988421
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60907767
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58716998
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58449369
66Platelet activation_Homo sapiens_hsa046110.57494637
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.57023234
68Acute myeloid leukemia_Homo sapiens_hsa052210.54883907
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54469849
70Pancreatic cancer_Homo sapiens_hsa052120.54077362
71Prolactin signaling pathway_Homo sapiens_hsa049170.51060567
72Proteoglycans in cancer_Homo sapiens_hsa052050.50862600
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50339125
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.49756769
75Small cell lung cancer_Homo sapiens_hsa052220.48847389
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45359964
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44368070
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.42916072
79Galactose metabolism_Homo sapiens_hsa000520.42704386
80Mineral absorption_Homo sapiens_hsa049780.41397297
81Focal adhesion_Homo sapiens_hsa045100.39896789
82VEGF signaling pathway_Homo sapiens_hsa043700.39307428
83Vibrio cholerae infection_Homo sapiens_hsa051100.38326349
84Caffeine metabolism_Homo sapiens_hsa002320.37723621
85Arachidonic acid metabolism_Homo sapiens_hsa005900.36967271
86Vitamin digestion and absorption_Homo sapiens_hsa049770.33905025
87Sulfur metabolism_Homo sapiens_hsa009200.33342570
88Epstein-Barr virus infection_Homo sapiens_hsa051690.32679561
89ECM-receptor interaction_Homo sapiens_hsa045120.32224110
90TGF-beta signaling pathway_Homo sapiens_hsa043500.29158254
91HIF-1 signaling pathway_Homo sapiens_hsa040660.28754241
92Renal cell carcinoma_Homo sapiens_hsa052110.27309363
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26853529
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25627638
95FoxO signaling pathway_Homo sapiens_hsa040680.25160974
96Notch signaling pathway_Homo sapiens_hsa043300.24877116
97HTLV-I infection_Homo sapiens_hsa051660.24103304
98Tryptophan metabolism_Homo sapiens_hsa003800.22607763
99Histidine metabolism_Homo sapiens_hsa003400.22600097
100Viral carcinogenesis_Homo sapiens_hsa052030.22565350
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22275387
102Insulin resistance_Homo sapiens_hsa049310.22123745
103Dorso-ventral axis formation_Homo sapiens_hsa043200.21906437
104MAPK signaling pathway_Homo sapiens_hsa040100.21576972
105Type II diabetes mellitus_Homo sapiens_hsa049300.21253705
106Ras signaling pathway_Homo sapiens_hsa040140.21158506
107Endocytosis_Homo sapiens_hsa041440.21000621
108Renin-angiotensin system_Homo sapiens_hsa046140.20861657
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.20465878
110Fatty acid biosynthesis_Homo sapiens_hsa000610.19603889
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18825502
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16935881
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.16436982
114* PPAR signaling pathway_Homo sapiens_hsa033200.11954348
115GnRH signaling pathway_Homo sapiens_hsa049120.11534107
116Systemic lupus erythematosus_Homo sapiens_hsa053220.10500342

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