OMD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cartilage development involved in endochondral bone morphogenesis (GO:0060351)9.72956427
2cartilage condensation (GO:0001502)8.92503694
3cell aggregation (GO:0098743)8.92503694
4response to parathyroid hormone (GO:0071107)8.70569371
5chondrocyte development (GO:0002063)8.58340129
6collagen fibril organization (GO:0030199)8.20909499
7positive regulation of extracellular matrix organization (GO:1903055)7.29813063
8* keratan sulfate catabolic process (GO:0042340)7.18113238
9DNA double-strand break processing (GO:0000729)6.98804729
10phosphate ion homeostasis (GO:0055062)6.92275368
11trivalent inorganic anion homeostasis (GO:0072506)6.92275368
12notochord development (GO:0030903)6.31693391
13collagen catabolic process (GO:0030574)6.12103379
14protein heterotrimerization (GO:0070208)6.08808601
15regulation of extracellular matrix disassembly (GO:0010715)6.07825859
16limb bud formation (GO:0060174)5.98934687
17collagen metabolic process (GO:0032963)5.96552832
18replacement ossification (GO:0036075)5.77329101
19endochondral ossification (GO:0001958)5.77329101
20multicellular organismal catabolic process (GO:0044243)5.60513130
21multicellular organismal macromolecule metabolic process (GO:0044259)5.56798785
22sphingomyelin metabolic process (GO:0006684)5.37030320
23multicellular organismal metabolic process (GO:0044236)5.33824390
24skin morphogenesis (GO:0043589)5.19430829
25cartilage development (GO:0051216)5.13521075
26chondrocyte proliferation (GO:0035988)5.02615073
27embryonic skeletal joint morphogenesis (GO:0060272)4.98700574
28proteoglycan metabolic process (GO:0006029)4.90512262
29chondroitin sulfate biosynthetic process (GO:0030206)4.85705149
30regulation of extracellular matrix organization (GO:1903053)4.81143160
31negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.72592156
32regulation of plasminogen activation (GO:0010755)4.65619216
33extracellular matrix disassembly (GO:0022617)4.61890352
34endodermal cell differentiation (GO:0035987)4.45663021
35chondrocyte differentiation (GO:0002062)4.44869028
36skeletal system development (GO:0001501)4.44010952
37negative regulation of chondrocyte differentiation (GO:0032331)4.43868210
38tooth mineralization (GO:0034505)4.42078998
39mitochondrial DNA replication (GO:0006264)4.40158195
40endocardial cushion morphogenesis (GO:0003203)4.34527379
41protein retention in ER lumen (GO:0006621)4.34226362
42iron ion import (GO:0097286)4.34140972
43short-term memory (GO:0007614)4.33067324
44bone trabecula formation (GO:0060346)4.31961388
45positive regulation of cartilage development (GO:0061036)4.27712933
46maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.20366657
47cellular response to BMP stimulus (GO:0071773)4.19459668
48response to BMP (GO:0071772)4.19459668
49peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.16997386
50negative regulation of bone mineralization (GO:0030502)4.15018894
51sequestering of extracellular ligand from receptor (GO:0035581)4.10897088
52cellular glucuronidation (GO:0052695)4.09640609
53peptidyl-proline hydroxylation (GO:0019511)4.09472378
54endothelial cell morphogenesis (GO:0001886)4.09416287
55response to gravity (GO:0009629)4.00736336
56biomineral tissue development (GO:0031214)4.00359094
57regulation of DNA endoreduplication (GO:0032875)4.00245186
58positive regulation of hormone biosynthetic process (GO:0046886)3.93832702
59positive regulation of chondrocyte differentiation (GO:0032332)3.92009909
60positive regulation of osteoblast proliferation (GO:0033690)3.89840243
61DNA replication checkpoint (GO:0000076)3.84396091
62replication fork processing (GO:0031297)3.83571757
63negative regulation of smooth muscle cell differentiation (GO:0051151)3.82627050
64regulation of chondrocyte differentiation (GO:0032330)3.82359966
65negative regulation of BMP signaling pathway (GO:0030514)3.75826371
66regulation of steroid hormone biosynthetic process (GO:0090030)3.74427235
67regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.72743218
68mesenchyme morphogenesis (GO:0072132)3.72245346
69regulation of bone mineralization (GO:0030500)3.71176205
70ossification (GO:0001503)3.67844778
71uronic acid metabolic process (GO:0006063)3.67282891
72glucuronate metabolic process (GO:0019585)3.67282891
73negative regulation of cartilage development (GO:0061037)3.67035466
74regulation of biomineral tissue development (GO:0070167)3.65761366
75negative regulation of DNA-dependent DNA replication (GO:2000104)3.63857219
76regulation of cartilage development (GO:0061035)3.62422728
77negative regulation of glycogen biosynthetic process (GO:0045719)3.60952246
78extracellular matrix organization (GO:0030198)3.60005523
79extracellular structure organization (GO:0043062)3.58751222
80positive regulation of epidermal cell differentiation (GO:0045606)3.57525280
81connective tissue development (GO:0061448)3.51452577
82positive regulation of receptor internalization (GO:0002092)3.51085275
83COPII vesicle coating (GO:0048208)3.46605434
84protein hydroxylation (GO:0018126)3.43638893
85negative regulation of glycogen metabolic process (GO:0070874)3.40159882
86bone mineralization (GO:0030282)3.39234335
87nucleotide-sugar biosynthetic process (GO:0009226)3.38317904
88positive regulation of p38MAPK cascade (GO:1900745)3.35606599
89decidualization (GO:0046697)3.30144545
90glycoprotein metabolic process (GO:0009100)3.27947926
91attachment of spindle microtubules to kinetochore (GO:0008608)3.24851401
92embryonic cranial skeleton morphogenesis (GO:0048701)3.23336615
93hypotonic response (GO:0006971)3.22848710
94regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.17921054
95bone development (GO:0060348)3.15259881
96chondroitin sulfate metabolic process (GO:0030204)3.13921235
97protein carboxylation (GO:0018214)3.12779859
98peptidyl-glutamic acid carboxylation (GO:0017187)3.12779859
99mesenchymal-epithelial cell signaling (GO:0060638)3.12778658
100* glycosaminoglycan biosynthetic process (GO:0006024)3.11890721
101* aminoglycan biosynthetic process (GO:0006023)3.07556261
102positive regulation of protein autophosphorylation (GO:0031954)3.06535211
103regulation of nuclear cell cycle DNA replication (GO:0033262)3.06017328
104regulation of hormone biosynthetic process (GO:0046885)3.05438253
105platelet dense granule organization (GO:0060155)3.04726851
106positive regulation of glycolytic process (GO:0045821)3.04398246
107* keratan sulfate biosynthetic process (GO:0018146)3.00742353
108DNA catabolic process, exonucleolytic (GO:0000738)3.00136885
109response to X-ray (GO:0010165)2.98962639
110COPI coating of Golgi vesicle (GO:0048205)2.98962355
111Golgi transport vesicle coating (GO:0048200)2.98962355
112positive regulation of muscle hypertrophy (GO:0014742)2.98722070
113positive regulation of cardiac muscle hypertrophy (GO:0010613)2.98722070
114cell proliferation involved in kidney development (GO:0072111)2.96633134
115positive regulation of hormone metabolic process (GO:0032352)2.95037807
116regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.91958668
117regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90341788
118regulation of mitotic spindle checkpoint (GO:1903504)2.90341788
119* glycosaminoglycan catabolic process (GO:0006027)2.88904721
120regulation of meiosis I (GO:0060631)2.88684561
121chromatin remodeling at centromere (GO:0031055)2.85858150
122maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84977819
123dermatan sulfate biosynthetic process (GO:0030208)2.84498709
124UDP-N-acetylglucosamine metabolic process (GO:0006047)2.83337710
125positive regulation of endothelial cell differentiation (GO:0045603)2.82779805
126type B pancreatic cell development (GO:0003323)2.81552407
127negative regulation of complement activation (GO:0045916)2.80189026
128* sulfur compound catabolic process (GO:0044273)2.79195463
1294-hydroxyproline metabolic process (GO:0019471)2.78563740
130regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.77980914
131negative regulation of biomineral tissue development (GO:0070168)2.77781916
132epithelial to mesenchymal transition (GO:0001837)2.76887203
133pericardium development (GO:0060039)2.76481691
134protein trimerization (GO:0070206)2.75881528
135negative regulation of JUN kinase activity (GO:0043508)2.75580553
136kidney mesenchyme development (GO:0072074)2.74275158
137CENP-A containing nucleosome assembly (GO:0034080)2.73751038
138histone exchange (GO:0043486)2.72156223
139lymphangiogenesis (GO:0001946)2.71842735
140* aminoglycan catabolic process (GO:0006026)2.71650917
141regulation of bone remodeling (GO:0046850)2.60819282
142signal peptide processing (GO:0006465)2.60394488
143mitotic sister chromatid cohesion (GO:0007064)2.59929928
144regulation of centriole replication (GO:0046599)2.58355607
145regulation of sarcomere organization (GO:0060297)2.57512295
146atrial cardiac muscle cell action potential (GO:0086014)2.53196521
147positive regulation of cardiac muscle tissue growth (GO:0055023)2.51731962
148negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.51228678
149double-strand break repair via homologous recombination (GO:0000724)2.48935003
150DNA-dependent DNA replication (GO:0006261)2.48870646
151regulation of alkaline phosphatase activity (GO:0010692)2.48233877
152recombinational repair (GO:0000725)2.48125081
153regulation of phospholipase A2 activity (GO:0032429)2.45563429
154negative regulation of JNK cascade (GO:0046329)2.45387613
155telomere maintenance via telomerase (GO:0007004)2.45039475
156cellular response to vitamin (GO:0071295)2.44137637
157replicative senescence (GO:0090399)2.43888863
158lipid particle organization (GO:0034389)2.42638518
159negative regulation of translation, ncRNA-mediated (GO:0040033)2.42134959
160regulation of translation, ncRNA-mediated (GO:0045974)2.42134959
161negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.42134959
162smooth muscle tissue development (GO:0048745)2.41609885
163negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:2.40939736
164positive regulation of cardiac muscle cell proliferation (GO:0060045)2.40213623
165negative regulation of protein activation cascade (GO:2000258)2.39229233
166negative regulation of protein autophosphorylation (GO:0031953)2.37642047
167kinetochore organization (GO:0051383)2.37477359
168postreplication repair (GO:0006301)2.37259328
169regulation of receptor internalization (GO:0002090)2.35290748
170regulation of cardiac muscle hypertrophy (GO:0010611)2.33822754
171regulation of BMP signaling pathway (GO:0030510)2.32540414
172regulation of protein autophosphorylation (GO:0031952)2.32232436
173protein prenylation (GO:0018342)2.31584644
174prenylation (GO:0097354)2.31584644
175inner ear receptor stereocilium organization (GO:0060122)2.31086552
176artery development (GO:0060840)2.30826208
177virion attachment to host cell (GO:0019062)2.29472311
178adhesion of symbiont to host cell (GO:0044650)2.29472311
179ventricular cardiac muscle cell development (GO:0055015)2.29276097
180regulation of centrosome duplication (GO:0010824)2.27225847

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.55983317
2AR_21572438_ChIP-Seq_LNCaP_Human3.98065746
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.91895989
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.38098302
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.21142053
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.79367454
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.77390373
8GATA1_22025678_ChIP-Seq_K562_Human2.72772872
9* SALL1_21062744_ChIP-ChIP_HESCs_Human2.65556830
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.63589217
11ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.62652401
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62367855
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.59138961
14CJUN_26792858_Chip-Seq_BT549_Human2.58912348
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.56591632
16CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.53831653
17CLOCK_20551151_ChIP-Seq_293T_Human2.43947959
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32841269
19VDR_22108803_ChIP-Seq_LS180_Human2.29505634
20P300_19829295_ChIP-Seq_ESCs_Human2.24447749
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.12366582
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.10914472
23CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.09855901
24FUS_26573619_Chip-Seq_HEK293_Human2.09322337
25ESR2_21235772_ChIP-Seq_MCF-7_Human2.02029026
26NRF2_20460467_ChIP-Seq_MEFs_Mouse2.01516771
27NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.01516771
28GBX2_23144817_ChIP-Seq_PC3_Human2.00202677
29TRIM28_21343339_ChIP-Seq_HEK293_Human10.0402469
30* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.96276403
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.93017661
32TAF15_26573619_Chip-Seq_HEK293_Human1.90399661
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.88276846
34EWS_26573619_Chip-Seq_HEK293_Human1.87741556
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.86774516
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.86563719
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84876959
38BRD4_25478319_ChIP-Seq_HGPS_Human1.80335267
39E2F7_22180533_ChIP-Seq_HELA_Human1.78653066
40SMAD4_21799915_ChIP-Seq_A2780_Human1.78001350
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77752587
42BCAT_22108803_ChIP-Seq_LS180_Human1.72911484
43TP53_18474530_ChIP-ChIP_U2OS_Human1.72383601
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72090546
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.72014254
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.70728200
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67799913
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.67791171
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.65539460
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63377771
51RXR_22108803_ChIP-Seq_LS180_Human1.60679226
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.59189712
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.58701583
54SOX2_20726797_ChIP-Seq_SW620_Human1.58083886
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58077832
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54075192
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53637780
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.52646240
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49892370
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48876459
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48273293
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47704162
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.46466478
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44260773
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43632259
66P53_22387025_ChIP-Seq_ESCs_Mouse1.41476674
67STAT3_23295773_ChIP-Seq_U87_Human1.41189593
68* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40553603
69ER_23166858_ChIP-Seq_MCF-7_Human1.39604716
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38957667
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.38140474
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35835282
73CDX2_22108803_ChIP-Seq_LS180_Human1.35484708
74IGF1R_20145208_ChIP-Seq_DFB_Human1.33012348
75SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32831127
76OCT4_21477851_ChIP-Seq_ESCs_Mouse1.31363177
77AR_25329375_ChIP-Seq_VCAP_Human1.30908362
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30871890
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30533661
80SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.28912210
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.28096027
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27925205
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27925205
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.27806684
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26387893
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25696379
87* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25067583
88* CBP_20019798_ChIP-Seq_JUKART_Human1.25067583
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24932009
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.24464218
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24207781
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23518620
93SA1_22415368_ChIP-Seq_MEFs_Mouse1.23498387
94ELK1_19687146_ChIP-ChIP_HELA_Human1.23243543
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23243102
96TCF4_23295773_ChIP-Seq_U87_Human1.23234372
97ZNF274_21170338_ChIP-Seq_K562_Hela1.22686731
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.22624649
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22348694
100P300_18555785_Chip-Seq_ESCs_Mouse1.22140956
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21547699
102GATA3_24758297_ChIP-Seq_MCF-7_Human1.21545637
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21160084
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20357870
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.19827204
106TP53_16413492_ChIP-PET_HCT116_Human1.18913015
107VDR_24787735_ChIP-Seq_THP-1_Human1.18356353
108SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.17939675
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.13320249
110SOX2_19829295_ChIP-Seq_ESCs_Human1.12793978
111NANOG_19829295_ChIP-Seq_ESCs_Human1.12793978
112AR_21909140_ChIP-Seq_LNCAP_Human1.12682407
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12472098
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11549090
115PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11443778
116NMYC_18555785_Chip-Seq_ESCs_Mouse1.10527741
117ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08701783
118TBL1_22424771_ChIP-Seq_293T_Human1.08189624
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.08129939
120KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07663550
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07493160
122TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07125128
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06796154
124RUNX2_22187159_ChIP-Seq_PCA_Human1.06696965
125ESR1_20079471_ChIP-ChIP_T-47D_Human1.05277449
126SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05027809
127FOXO3_23340844_ChIP-Seq_DLD1_Human1.02862850
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02292237
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01919264
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00688430
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99546727
132CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97717919
133GATA2_21666600_ChIP-Seq_HMVEC_Human0.97576472
134ELK1_22589737_ChIP-Seq_MCF10A_Human0.97412747
135SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96084100
136PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95676805
137SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94480106
138FLI1_27457419_Chip-Seq_LIVER_Mouse0.93980579
139ELF5_23300383_ChIP-Seq_T47D_Human0.92989890
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92699679
141KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92399310
142* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92009435
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91383647
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.90693651
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.90462407
146SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90224328
147EGR1_19032775_ChIP-ChIP_M12_Human0.89170587
148EZH2_27304074_Chip-Seq_ESCs_Mouse0.89088056
149EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88824550
150RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88824550
151RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88755344
152TCF4_22108803_ChIP-Seq_LS180_Human0.87782793
153NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87450716
154TP63_23658742_ChIP-Seq_EP156T_Human0.87196159
155PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86833024
156EGR1_19374776_ChIP-ChIP_THP-1_Human0.85751693
157TBX20_22080862_ChIP-Seq_HEART_Mouse0.85104607
158TBX20_22328084_ChIP-Seq_HEART_Mouse0.85104607
159PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84181813
160P63_26484246_Chip-Seq_KERATINOCYTES_Human0.83448147
161EZH2_27294783_Chip-Seq_NPCs_Mouse0.83054913
162SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82748169
163FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.82290269
164EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82258189
165OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81168601
166SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80225647
167SMC3_22415368_ChIP-Seq_MEFs_Mouse0.79161651
168AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78913541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology6.04526988
2MP0008438_abnormal_cutaneous_collagen5.63712019
3MP0004134_abnormal_chest_morphology4.24196354
4MP0002933_joint_inflammation4.07970327
5MP0005275_abnormal_skin_tensile4.02828952
6MP0003283_abnormal_digestive_organ4.02009339
7MP0002282_abnormal_trachea_morphology3.79741246
8MP0001542_abnormal_bone_strength3.60988538
9MP0009250_abnormal_appendicular_skeleto3.60207722
10MP0000163_abnormal_cartilage_morphology3.30652294
11MP0005083_abnormal_biliary_tract3.27213716
12MP0002115_abnormal_skeleton_extremities2.86573907
13MP0002896_abnormal_bone_mineralization2.82624622
14MP0005508_abnormal_skeleton_morphology2.81116086
15MP0008057_abnormal_DNA_replication2.63170018
16MP0009780_abnormal_chondrocyte_physiolo2.48214527
17MP0009384_cardiac_valve_regurgitation2.34458781
18MP0002113_abnormal_skeleton_development2.33501218
19MP0005390_skeleton_phenotype2.29814498
20MP0002089_abnormal_postnatal_growth/wei2.26180025
21MP0003195_calcinosis2.23572925
22MP0001299_abnormal_eye_distance/2.14421879
23MP0001533_abnormal_skeleton_physiology2.08520146
24MP0003279_aneurysm2.04567524
25MP0005084_abnormal_gallbladder_morpholo1.94469955
26MP0002139_abnormal_hepatobiliary_system1.90262403
27MP0003705_abnormal_hypodermis_morpholog1.89316409
28MP0000569_abnormal_digit_pigmentation1.88250327
29MP0002108_abnormal_muscle_morphology1.84867297
30MP0003795_abnormal_bone_structure1.84180722
31MP0003123_paternal_imprinting1.83846731
32MP0000762_abnormal_tongue_morphology1.76905535
33MP0001958_emphysema1.76550843
34MP0006054_spinal_hemorrhage1.73848329
35MP0002109_abnormal_limb_morphology1.73708753
36MP0003718_maternal_effect1.71131638
37MP0003646_muscle_fatigue1.61574202
38MP0002998_abnormal_bone_remodeling1.61225814
39MP0000372_irregular_coat_pigmentation1.59770032
40MP0002254_reproductive_system_inflammat1.57497503
41MP0002909_abnormal_adrenal_gland1.56971968
42MP0005023_abnormal_wound_healing1.54806195
43MP0004272_abnormal_basement_membrane1.52387054
44MP0000049_abnormal_middle_ear1.51251703
45MP0002060_abnormal_skin_morphology1.47335379
46MP0002116_abnormal_craniofacial_bone1.40248781
47MP0010368_abnormal_lymphatic_system1.40061780
48MP0003656_abnormal_erythrocyte_physiolo1.40031608
49MP0004215_abnormal_myocardial_fiber1.34091491
50MP0003566_abnormal_cell_adhesion1.34087797
51MP0003755_abnormal_palate_morphology1.33788728
52MP0003385_abnormal_body_wall1.30818811
53MP0002876_abnormal_thyroid_physiology1.29268307
54MP0005395_other_phenotype1.26279018
55MP0000432_abnormal_head_morphology1.25531927
56MP0008877_abnormal_DNA_methylation1.24557376
57MP0010094_abnormal_chromosome_stability1.23111673
58MP0001270_distended_abdomen1.21549979
59MP0010386_abnormal_urinary_bladder1.21325679
60MP0001243_abnormal_dermal_layer1.19391503
61MP0000343_altered_response_to1.19321746
62MP0002111_abnormal_tail_morphology1.15064416
63MP0002233_abnormal_nose_morphology1.13518084
64MP0003935_abnormal_craniofacial_develop1.12675781
65MP0003950_abnormal_plasma_membrane1.10283303
66MP0000751_myopathy1.09638597
67MP0004185_abnormal_adipocyte_glucose1.07723409
68MP0002102_abnormal_ear_morphology1.06798033
69MP0009697_abnormal_copulation1.04600197
70MP0001879_abnormal_lymphatic_vessel1.00695590
71MP0002114_abnormal_axial_skeleton1.00631840
72MP0002163_abnormal_gland_morphology0.99940031
73MP0002932_abnormal_joint_morphology0.99796728
74MP0008058_abnormal_DNA_repair0.98456063
75MP0008004_abnormal_stomach_pH0.96974988
76MP0005171_absent_coat_pigmentation0.95913690
77MP0004019_abnormal_vitamin_homeostasis0.95187107
78MP0005360_urolithiasis0.94668502
79MP0003091_abnormal_cell_migration0.94536713
80MP0005164_abnormal_response_to0.92699209
81MP0001666_abnormal_nutrient_absorption0.90762488
82MP0003942_abnormal_urinary_system0.90533935
83MP0002249_abnormal_larynx_morphology0.89595813
84MP0003937_abnormal_limbs/digits/tail_de0.88964842
85MP0003786_premature_aging0.88428394
86MP0002295_abnormal_pulmonary_circulatio0.86202230
87MP0000427_abnormal_hair_cycle0.85295997
88MP0005257_abnormal_intraocular_pressure0.85276797
89MP0010030_abnormal_orbit_morphology0.85097099
90MP0003787_abnormal_imprinting0.84939077
91MP0000462_abnormal_digestive_system0.83211104
92MP0005551_abnormal_eye_electrophysiolog0.82688962
93MP0003806_abnormal_nucleotide_metabolis0.81236247
94MP0004883_abnormal_blood_vessel0.76548694
95MP0006292_abnormal_olfactory_placode0.73230003
96MP0001177_atelectasis0.72644527
97MP0003941_abnormal_skin_development0.71801368
98MP0000613_abnormal_salivary_gland0.71268351
99MP0008007_abnormal_cellular_replicative0.69999133
100MP0004197_abnormal_fetal_growth/weight/0.69433004
101MP0003011_delayed_dark_adaptation0.69329248
102MP0004084_abnormal_cardiac_muscle0.67762195
103MP0003868_abnormal_feces_composition0.67598313
104MP0002938_white_spotting0.66423326
105MP0009115_abnormal_fat_cell0.65979664
106MP0004484_altered_response_of0.65895235
107MP0010307_abnormal_tumor_latency0.65718118
108MP0003436_decreased_susceptibility_to0.65228134
109MP0002090_abnormal_vision0.63320602
110MP0000428_abnormal_craniofacial_morphol0.62947963
111MP0005365_abnormal_bile_salt0.62885758
112MP0002234_abnormal_pharynx_morphology0.62790698
113MP0005381_digestive/alimentary_phenotyp0.62218268
114MP0000534_abnormal_ureter_morphology0.60300153
115MP0005253_abnormal_eye_physiology0.57078263
116MP0005623_abnormal_meninges_morphology0.56842325
117MP0002168_other_aberrant_phenotype0.56402561
118MP0000767_abnormal_smooth_muscle0.55849543
119MP0005076_abnormal_cell_differentiation0.55136657
120MP0004085_abnormal_heartbeat0.54613661
121MP0005085_abnormal_gallbladder_physiolo0.54356015
122MP0005646_abnormal_pituitary_gland0.50911850
123MP0009053_abnormal_anal_canal0.50633325
124MP0001346_abnormal_lacrimal_gland0.50025542
125MP0002837_dystrophic_cardiac_calcinosis0.49386954
126MP0000465_gastrointestinal_hemorrhage0.49060515
127MP0004036_abnormal_muscle_relaxation0.48484655
128MP0005386_behavior/neurological_phenoty0.48200084
129MP0004924_abnormal_behavior0.48200084
130MP0005165_increased_susceptibility_to0.48174315
131MP0005452_abnormal_adipose_tissue0.48143001
132MP0000516_abnormal_urinary_system0.47784523
133MP0005166_decreased_susceptibility_to0.47603751
134MP0003252_abnormal_bile_duct0.46328804
135MP0003119_abnormal_digestive_system0.45730819
136MP0001663_abnormal_digestive_system0.44456500
137MP0001286_abnormal_eye_development0.42875861
138MP0005379_endocrine/exocrine_gland_phen0.41635696
139MP0002128_abnormal_blood_circulation0.41213456
140MP0005193_abnormal_anterior_eye0.40683886
141MP0003448_altered_tumor_morphology0.40506584
142MP0008775_abnormal_heart_ventricle0.40450109
143MP0005595_abnormal_vascular_smooth0.37310661
144MP0002133_abnormal_respiratory_system0.36767251
145MP0005388_respiratory_system_phenotype0.36767251
146MP0000733_abnormal_muscle_development0.34896776

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)9.60733180
2Hypophosphatemic rickets (HP:0004912)8.84079950
3Epiphyseal dysplasia (HP:0002656)8.68081359
4Irregular epiphyses (HP:0010582)8.03311831
5Increased density of long bones (HP:0006392)7.40158550
6Vitreoretinal degeneration (HP:0000655)7.25046483
7Hypoplastic ischia (HP:0003175)6.28536008
8Cupped ribs (HP:0000887)6.20284706
9Facial diplegia (HP:0001349)6.00864753
10Small epiphyses (HP:0010585)5.90328611
11Abnormality of the ischium (HP:0003174)5.57657336
12Abnormality of calcium-phosphate metabolism (HP:0100530)5.50757321
13Abnormal tarsal ossification (HP:0008369)5.38860092
14Metaphyseal cupping (HP:0003021)5.25917077
15Overgrowth (HP:0001548)5.12632085
16Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.08700811
17Broad ribs (HP:0000885)5.03346148
18Neonatal short-limb short stature (HP:0008921)5.01620502
19Flat capital femoral epiphysis (HP:0003370)4.80401965
20Genu varum (HP:0002970)4.78067221
21Mild short stature (HP:0003502)4.46884314
22Flat acetabular roof (HP:0003180)4.40101312
23Metaphyseal dysplasia (HP:0100255)4.31667836
24Delayed epiphyseal ossification (HP:0002663)4.28191208
25Craniofacial hyperostosis (HP:0004493)4.20468952
26Abnormal foot bone ossification (HP:0010675)4.19645827
27Abnormality of the vertebral endplates (HP:0005106)4.15131472
28Flattened epiphyses (HP:0003071)4.07395741
29Osteoarthritis (HP:0002758)4.05633143
30Arthropathy (HP:0003040)3.92396246
31Irregular vertebral endplates (HP:0003301)3.91300287
32Abnormality of femoral epiphyses (HP:0006499)3.89209052
33Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.89209052
34Spondylolisthesis (HP:0003302)3.79786279
35Absent epiphyses (HP:0010577)3.72899315
36Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.72899315
37Rickets (HP:0002748)3.64791937
38Femoral bowing (HP:0002980)3.64663159
39Cranial hyperostosis (HP:0004437)3.60678531
40Abnormality of the epiphysis of the femoral head (HP:0010574)3.42999416
41Abnormality of the phalanges of the 2nd finger (HP:0009541)3.40685853
42Abnormal vertebral ossification (HP:0100569)3.39509011
43Cervical subluxation (HP:0003308)3.39042333
44Protrusio acetabuli (HP:0003179)3.31701205
45Absent frontal sinuses (HP:0002688)3.29451880
46Short femoral neck (HP:0100864)3.27348925
47Sudden death (HP:0001699)3.27049645
48Metaphyseal irregularity (HP:0003025)3.26735777
49Coxa vara (HP:0002812)3.25912468
50Choanal stenosis (HP:0000452)3.25232592
51Protuberant abdomen (HP:0001538)3.19572844
52Abnormality of the femoral head (HP:0003368)3.12674760
53Platyspondyly (HP:0000926)3.11285014
54Osteomalacia (HP:0002749)3.03900003
55Abnormality of the proximal phalanges of the hand (HP:0009834)3.01764026
56Constricted visual fields (HP:0001133)3.00173436
57Premature rupture of membranes (HP:0001788)2.98493081
58Abnormality of carpal bone ossification (HP:0006257)2.97534303
59Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.92847439
60Abnormality of the pubic bones (HP:0003172)2.90230140
61Stillbirth (HP:0003826)2.71599599
62Thoracolumbar scoliosis (HP:0002944)2.71079707
63Persistence of primary teeth (HP:0006335)2.69678319
64Beaking of vertebral bodies (HP:0004568)2.67938965
65Enlarged epiphyses (HP:0010580)2.61608881
66Ovoid vertebral bodies (HP:0003300)2.60142641
67Vertebral clefting (HP:0008428)2.58325026
68Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.56939454
69Limited elbow extension (HP:0001377)2.51968495
70Thin ribs (HP:0000883)2.50847330
71Abnormality of the 2nd finger (HP:0004100)2.49975668
72Aortic dissection (HP:0002647)2.49283644
73Ulnar bowing (HP:0003031)2.48829232
74Long clavicles (HP:0000890)2.48068734
75Abnormality of incisor morphology (HP:0011063)2.46445195
76Abnormality of the acetabulum (HP:0003170)2.46115142
77Waddling gait (HP:0002515)2.44366591
78Follicular hyperkeratosis (HP:0007502)2.40647965
79Hypophosphatemia (HP:0002148)2.40097573
80Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.39337557
81Exostoses (HP:0100777)2.34471595
82Biconcave vertebral bodies (HP:0004586)2.32941930
83Fibular hypoplasia (HP:0003038)2.32912123
84Abnormal hand bone ossification (HP:0010660)2.31892367
85Aplasia/hypoplasia of the femur (HP:0005613)2.28146318
86Abnormal ossification of hand bones (HP:0005921)2.26542447
87Disproportionate short-trunk short stature (HP:0003521)2.25312094
88Limited hip movement (HP:0008800)2.24459254
89Aortic aneurysm (HP:0004942)2.22355979
90Spinal cord compression (HP:0002176)2.21956582
91Radial bowing (HP:0002986)2.21514564
92Barrel-shaped chest (HP:0001552)2.20955472
93Broad long bones (HP:0005622)2.19483419
94Hip contracture (HP:0003273)2.18829394
95Abnormality of the lumbar spine (HP:0100712)2.17591642
96Abnormal cartilage morphology (HP:0002763)2.17178574
97Lumbar hyperlordosis (HP:0002938)2.16921822
98Vascular tortuosity (HP:0004948)2.15284279
99Abnormality of the frontal sinuses (HP:0002687)2.14234325
100Wormian bones (HP:0002645)2.14106644
101Glossoptosis (HP:0000162)2.14014703
102Ankle contracture (HP:0006466)2.13452972
103Abnormality of the phalanges of the 5th finger (HP:0004213)2.10489220
104Abnormality of the vitreous humor (HP:0004327)2.08315694
105Broad phalanx (HP:0006009)2.06123680
106Carpal bone hypoplasia (HP:0001498)2.05567330
107Flared metaphyses (HP:0003015)2.05038956
108Soft skin (HP:0000977)2.04740083
109Hypoplasia of the odontoid process (HP:0003311)2.04664066
110Mesomelia (HP:0003027)2.03774328
111Abnormality of Sharpey fibers (HP:0100685)2.02023336
112Micromelia (HP:0002983)2.01805176
113Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.01455269
114Vertebral hypoplasia (HP:0008417)2.01455269
115Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.01102623
116Papilledema (HP:0001085)13.3629674
117Aplasia/Hypoplasia of the uvula (HP:0010293)1.99916283
118Tibial bowing (HP:0002982)1.98144298
119Delayed closure of the anterior fontanelle (HP:0001476)1.96314553
120Short middle phalanx of finger (HP:0005819)1.94930373
121Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.93709716
122Short ribs (HP:0000773)1.93041554
123Hypoplastic ilia (HP:0000946)1.89617597
124Decreased skull ossification (HP:0004331)1.89340308
125Arterial tortuosity (HP:0005116)1.89026034
126Blue sclerae (HP:0000592)1.88158330
127Rhizomelia (HP:0008905)1.86897579
128Abnormality of dentin (HP:0010299)1.86745187
129Osteolytic defects of the phalanges of the hand (HP:0009771)1.83526916
130Osteolytic defects of the hand bones (HP:0009699)1.83526916
131Slender build (HP:0001533)1.81341074
132Abnormality of the middle phalanges of the hand (HP:0009833)1.78297910
133Short middle phalanx of the 5th finger (HP:0004220)1.77617499
134Progressive visual loss (HP:0000529)1.73604731
135Volvulus (HP:0002580)1.71744072
136Increased corneal curvature (HP:0100692)1.71162440
137Keratoconus (HP:0000563)1.71162440
138Elevated alkaline phosphatase (HP:0003155)1.71058588
139Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.70630821
140Flared iliac wings (HP:0002869)1.62388954
141Abnormality of chromosome stability (HP:0003220)1.57003774
142Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.56632591
143Chromsome breakage (HP:0040012)1.53989146
144Abnormality of the labia minora (HP:0012880)1.51675720
145Ectopic kidney (HP:0000086)1.50392268
146Abnormality of alkaline phosphatase activity (HP:0004379)1.48525938
147Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.47090581
148Meckel diverticulum (HP:0002245)1.45958713
149Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.45642597
150Abnormality of the ileum (HP:0001549)1.43864436
151Abnormal enzyme/coenzyme activity (HP:0012379)1.43304037
152Microglossia (HP:0000171)1.41685081
153Chromosomal breakage induced by crosslinking agents (HP:0003221)1.38546601
154Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.36009886
155Abnormality of the epiphyses of the hand (HP:0005924)1.35886069
156Abnormal cortical bone morphology (HP:0003103)1.35688932
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.35030691
158Pancreatic fibrosis (HP:0100732)1.32427234
159Aqueductal stenosis (HP:0002410)1.32414173
160Convex nasal ridge (HP:0000444)1.27394897
161Exertional dyspnea (HP:0002875)1.27090685
162Hypoplastic scapulae (HP:0000882)1.27083131
163Aplasia/Hypoplasia of the scapulae (HP:0006713)1.27083131
164Esotropia (HP:0000565)1.26903385
165Striae distensae (HP:0001065)1.25775587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR28.33117239
2MAP3K37.35353350
3STK38L4.40791741
4STK244.34935306
5PRKG23.04601117
6TNIK3.01423215
7TRIM282.76818063
8PNCK2.70269776
9NEK12.60343610
10NME12.39705300
11WEE12.39044251
12MAP4K22.33347366
13BMPR1B2.28511665
14BRSK22.25454714
15BUB12.04547454
16SIK12.03228771
17ERBB31.91300228
18NLK1.83595469
19STK31.81512483
20LATS11.79769633
21PLK21.64990832
22ACVR1B1.63593664
23NUAK11.61514237
24PLK41.57606431
25TRIB31.56567975
26WNK31.54365445
27TRPM71.52783886
28PIK3CA1.49907160
29MYLK1.48093432
30MET1.43144029
31EPHB21.39507960
32TAF11.38824961
33EIF2AK31.38763313
34MST41.38645482
35AKT31.30282714
36GRK11.25082587
37PIM21.23166069
38DYRK1A1.19368264
39EIF2AK11.15876094
40INSRR1.15394541
41NME21.15231684
42ROCK11.05037302
43MKNK11.02680014
44CASK1.00845411
45CCNB11.00543809
46CAMK1G1.00159625
47MAPK120.98762521
48PDGFRA0.96977596
49TTN0.96063133
50PBK0.93848933
51MKNK20.93629732
52MAPK40.91216411
53TTK0.91215704
54PIK3CG0.90947859
55EIF2AK20.89323894
56MAP3K40.89318619
57OXSR10.88554404
58PRKCE0.88316467
59TIE10.87946483
60TGFBR20.85499783
61EPHA30.84944201
62MUSK0.83559133
63SIK30.83143307
64TESK10.82887466
65TSSK60.80590848
66GSK3A0.79958063
67DMPK0.79120851
68MAPK70.78386296
69ERN10.75337392
70FRK0.73028590
71PLK10.71108234
72LIMK10.68608738
73TAOK10.67759872
74FLT30.66999093
75NEK90.66798652
76GRK50.65259389
77PDGFRB0.64612824
78CSF1R0.64330390
79FGFR10.63329955
80SGK20.63302802
81WNK40.61852814
82BRSK10.60464206
83PLK30.60288078
84FER0.57808322
85TAOK20.56098589
86PINK10.52269801
87RPS6KA40.52067728
88ERBB40.51711405
89MELK0.51634495
90VRK20.51437939
91EPHA40.51385119
92PTK20.50244867
93NEK60.50159637
94VRK10.49447311
95PKN10.46677448
96BCR0.46545755
97EPHA20.46321822
98ATM0.45901698
99ATR0.45087823
100PTK2B0.45029281
101PAK20.42925816
102FGFR30.42567073
103CDC70.42136479
104TEC0.41755797
105MST1R0.41657946
106STK40.41218805
107MAPKAPK50.41183729
108LRRK20.38793023
109LATS20.38424960
110ADRBK20.37488471
111OBSCN0.37233232
112CAMK2D0.36266828
113STK390.36173632
114IGF1R0.35180392
115CAMK10.35107922
116MAP2K30.34436434
117PKN20.34387144
118MAPK30.33850663
119NTRK20.33751638
120IKBKB0.33714404
121MINK10.33405029
122PAK30.33312234
123CDK80.32681138
124STK100.31845265
125CSNK1G10.30968139
126PRKG10.30878076
127RPS6KB10.30775145
128PIM10.30499447
129GRK70.30247072
130ILK0.29841969
131TGFBR10.29801033
132CDK60.29632794
133INSR0.29043557
134ADRBK10.28962706
135MAP3K120.26031836
136MAPK10.25809103
137PRKCG0.25563947
138PDK20.24167318
139JAK10.21531292
140CAMK1D0.20696148
141ABL20.20231329
142BMX0.19985341
143ABL10.19927190
144PRKACG0.19323401
145PRKCI0.18807961
146CHUK0.18563812
147AURKB0.17710793
148RIPK10.16991219
149MAPK100.16887995
150FGFR20.16423248
151ZAK0.16087376
152RET0.15277714
153PRKD30.15272075
154ROCK20.14841733
155CSNK1A1L0.14413076
156CSK0.14069794
157MTOR0.13548773

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045126.51223357
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005326.13182644
3Protein digestion and absorption_Homo sapiens_hsa049745.75980468
4Non-homologous end-joining_Homo sapiens_hsa034503.17459206
5Fanconi anemia pathway_Homo sapiens_hsa034602.66874681
6Focal adhesion_Homo sapiens_hsa045102.62823409
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.26996886
8Steroid biosynthesis_Homo sapiens_hsa001002.23350638
9Homologous recombination_Homo sapiens_hsa034402.20109495
10Nitrogen metabolism_Homo sapiens_hsa009102.15162915
11Proteasome_Homo sapiens_hsa030502.03795664
12Sphingolipid metabolism_Homo sapiens_hsa006001.99141190
13TGF-beta signaling pathway_Homo sapiens_hsa043501.92912379
14Malaria_Homo sapiens_hsa051441.92666870
15Starch and sucrose metabolism_Homo sapiens_hsa005001.86267710
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.79604594
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.78489736
18Mismatch repair_Homo sapiens_hsa034301.73376153
19PI3K-Akt signaling pathway_Homo sapiens_hsa041511.72216595
20Vitamin B6 metabolism_Homo sapiens_hsa007501.67643267
21Fatty acid elongation_Homo sapiens_hsa000621.66589203
22DNA replication_Homo sapiens_hsa030301.65726561
23Complement and coagulation cascades_Homo sapiens_hsa046101.64284158
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63958165
25Phototransduction_Homo sapiens_hsa047441.63146240
26Sulfur metabolism_Homo sapiens_hsa009201.59550211
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56745106
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.53016473
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47038495
30Proteoglycans in cancer_Homo sapiens_hsa052051.43101188
31Circadian rhythm_Homo sapiens_hsa047101.42303595
32Folate biosynthesis_Homo sapiens_hsa007901.35098696
33Protein export_Homo sapiens_hsa030601.27932373
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25450932
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22542268
36RNA degradation_Homo sapiens_hsa030181.22227763
37Basal cell carcinoma_Homo sapiens_hsa052171.21393288
38Ovarian steroidogenesis_Homo sapiens_hsa049131.17440706
39Regulation of autophagy_Homo sapiens_hsa041401.16103932
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14551598
41Cell cycle_Homo sapiens_hsa041101.14220274
42Hippo signaling pathway_Homo sapiens_hsa043901.13578869
43Selenocompound metabolism_Homo sapiens_hsa004501.09684289
44Oocyte meiosis_Homo sapiens_hsa041141.07038755
45Hedgehog signaling pathway_Homo sapiens_hsa043401.05284141
46Arginine biosynthesis_Homo sapiens_hsa002201.03052267
47Linoleic acid metabolism_Homo sapiens_hsa005910.97695944
48Amoebiasis_Homo sapiens_hsa051460.96759880
49Ether lipid metabolism_Homo sapiens_hsa005650.96465368
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96216328
51Arginine and proline metabolism_Homo sapiens_hsa003300.95843135
52RNA polymerase_Homo sapiens_hsa030200.95757000
53Tryptophan metabolism_Homo sapiens_hsa003800.95045023
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.94927800
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94412471
56p53 signaling pathway_Homo sapiens_hsa041150.92101704
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86576269
58Basal transcription factors_Homo sapiens_hsa030220.85021928
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83810718
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83478337
61Chemical carcinogenesis_Homo sapiens_hsa052040.82930305
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81695834
63Glycerolipid metabolism_Homo sapiens_hsa005610.80590756
64One carbon pool by folate_Homo sapiens_hsa006700.78439320
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77688054
66Bile secretion_Homo sapiens_hsa049760.77041479
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76102220
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75089202
69Olfactory transduction_Homo sapiens_hsa047400.74719648
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71206665
71Renin secretion_Homo sapiens_hsa049240.70394659
72Thyroid hormone synthesis_Homo sapiens_hsa049180.68950124
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68712202
74Lysine degradation_Homo sapiens_hsa003100.67341807
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67068805
76Collecting duct acid secretion_Homo sapiens_hsa049660.66718010
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65749731
78Retinol metabolism_Homo sapiens_hsa008300.65692820
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65371671
80Vitamin digestion and absorption_Homo sapiens_hsa049770.65042626
81Phagosome_Homo sapiens_hsa041450.61676304
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60824787
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60824727
84Arachidonic acid metabolism_Homo sapiens_hsa005900.59939874
85PPAR signaling pathway_Homo sapiens_hsa033200.59485858
86Bladder cancer_Homo sapiens_hsa052190.57627029
87Fatty acid degradation_Homo sapiens_hsa000710.57217935
88Pyruvate metabolism_Homo sapiens_hsa006200.56419850
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.56252449
90Phenylalanine metabolism_Homo sapiens_hsa003600.55125769
91Purine metabolism_Homo sapiens_hsa002300.54334688
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54140553
93MicroRNAs in cancer_Homo sapiens_hsa052060.52972124
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52425552
95Other glycan degradation_Homo sapiens_hsa005110.52397669
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51905435
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50477194
98Dilated cardiomyopathy_Homo sapiens_hsa054140.49768218
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49400425
100Wnt signaling pathway_Homo sapiens_hsa043100.49357465
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.48643060
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48637469
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48624763
104Calcium signaling pathway_Homo sapiens_hsa040200.47244500
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44218953
106Glutathione metabolism_Homo sapiens_hsa004800.44068475
107RNA transport_Homo sapiens_hsa030130.42778102
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42767757
109Platelet activation_Homo sapiens_hsa046110.42056931
110Nucleotide excision repair_Homo sapiens_hsa034200.41881236
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41703280
112Mineral absorption_Homo sapiens_hsa049780.40552136
113Prostate cancer_Homo sapiens_hsa052150.40296878
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40281804
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39290665
116Insulin secretion_Homo sapiens_hsa049110.38855452
117N-Glycan biosynthesis_Homo sapiens_hsa005100.38687709
118Fatty acid metabolism_Homo sapiens_hsa012120.36784065
119Small cell lung cancer_Homo sapiens_hsa052220.36043695
120Tyrosine metabolism_Homo sapiens_hsa003500.35768987
121Staphylococcus aureus infection_Homo sapiens_hsa051500.34063964
122Adherens junction_Homo sapiens_hsa045200.32250988
123Caffeine metabolism_Homo sapiens_hsa002320.31776487
124beta-Alanine metabolism_Homo sapiens_hsa004100.30799767
125Butanoate metabolism_Homo sapiens_hsa006500.29976809
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28218684
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25910693
128Histidine metabolism_Homo sapiens_hsa003400.25591312
129Melanogenesis_Homo sapiens_hsa049160.24371845
130Propanoate metabolism_Homo sapiens_hsa006400.24185496
131Peroxisome_Homo sapiens_hsa041460.22003887
132Galactose metabolism_Homo sapiens_hsa000520.20970437
133Melanoma_Homo sapiens_hsa052180.20070090
134HTLV-I infection_Homo sapiens_hsa051660.18618874
135Gap junction_Homo sapiens_hsa045400.18299054
136Pathways in cancer_Homo sapiens_hsa052000.16834803
137Legionellosis_Homo sapiens_hsa051340.16639075
138Insulin resistance_Homo sapiens_hsa049310.15973707
139mTOR signaling pathway_Homo sapiens_hsa041500.14333531
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.13738383

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