

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | central nervous system myelination (GO:0022010) | 9.17763976 |
| 2 | axon ensheathment in central nervous system (GO:0032291) | 9.17763976 |
| 3 | cilium or flagellum-dependent cell motility (GO:0001539) | 8.71196319 |
| 4 | cilium movement (GO:0003341) | 7.41682660 |
| 5 | motile cilium assembly (GO:0044458) | 6.82052310 |
| 6 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 6.58128467 |
| 7 | epithelial cilium movement (GO:0003351) | 6.35290081 |
| 8 | fatty acid elongation (GO:0030497) | 6.17207156 |
| 9 | long-chain fatty acid biosynthetic process (GO:0042759) | 5.31502720 |
| 10 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 5.30299288 |
| 11 | myelination (GO:0042552) | 5.28996491 |
| 12 | axon ensheathment (GO:0008366) | 5.26209421 |
| 13 | ensheathment of neurons (GO:0007272) | 5.26209421 |
| 14 | axoneme assembly (GO:0035082) | 5.24450028 |
| 15 | presynaptic membrane organization (GO:0097090) | 5.03033707 |
| 16 | presynaptic membrane assembly (GO:0097105) | 4.98549970 |
| 17 | negative regulation of neurotransmitter transport (GO:0051589) | 4.81981084 |
| 18 | neuron cell-cell adhesion (GO:0007158) | 4.70088817 |
| 19 | cellular potassium ion homeostasis (GO:0030007) | 4.51930739 |
| 20 | negative regulation of neurotransmitter secretion (GO:0046929) | 4.46742507 |
| 21 | L-amino acid import (GO:0043092) | 4.33511224 |
| 22 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.15097239 |
| 23 | left/right pattern formation (GO:0060972) | 4.13603248 |
| 24 | negative regulation of protein localization to cell surface (GO:2000009) | 4.06254414 |
| 25 | sodium ion export (GO:0071436) | 3.97631036 |
| 26 | potassium ion homeostasis (GO:0055075) | 3.92802333 |
| 27 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.91195533 |
| 28 | myelin maintenance (GO:0043217) | 3.89042241 |
| 29 | negative regulation of inclusion body assembly (GO:0090084) | 3.87734159 |
| 30 | exploration behavior (GO:0035640) | 3.86686473 |
| 31 | microtubule bundle formation (GO:0001578) | 3.86469283 |
| 32 | neuronal action potential propagation (GO:0019227) | 3.84625033 |
| 33 | regulation of cilium movement (GO:0003352) | 3.83893815 |
| 34 | regulation of synaptic vesicle transport (GO:1902803) | 3.78764004 |
| 35 | establishment of mitochondrion localization (GO:0051654) | 3.78456052 |
| 36 | oligodendrocyte differentiation (GO:0048709) | 3.76236714 |
| 37 | one-carbon compound transport (GO:0019755) | 3.74297723 |
| 38 | neurotransmitter secretion (GO:0007269) | 3.73139635 |
| 39 | apical protein localization (GO:0045176) | 3.67547593 |
| 40 | glycerophospholipid catabolic process (GO:0046475) | 3.67459820 |
| 41 | protein localization to cilium (GO:0061512) | 3.66840519 |
| 42 | ventricular system development (GO:0021591) | 3.59784270 |
| 43 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.56204853 |
| 44 | neurotransmitter uptake (GO:0001504) | 3.49196496 |
| 45 | transmission of nerve impulse (GO:0019226) | 3.46719935 |
| 46 | amino acid import (GO:0043090) | 3.46227577 |
| 47 | adult walking behavior (GO:0007628) | 3.40602528 |
| 48 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.40044488 |
| 49 | response to methylmercury (GO:0051597) | 3.38860426 |
| 50 | cholesterol biosynthetic process (GO:0006695) | 3.36811612 |
| 51 | synaptic vesicle exocytosis (GO:0016079) | 3.34377449 |
| 52 | potassium ion import (GO:0010107) | 3.34214617 |
| 53 | vitamin transmembrane transport (GO:0035461) | 3.32505690 |
| 54 | asymmetric protein localization (GO:0008105) | 3.29328587 |
| 55 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.28812639 |
| 56 | cellular sodium ion homeostasis (GO:0006883) | 3.27305771 |
| 57 | cerebellar granule cell differentiation (GO:0021707) | 3.24326872 |
| 58 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.23018109 |
| 59 | primary alcohol catabolic process (GO:0034310) | 3.16164839 |
| 60 | substantia nigra development (GO:0021762) | 3.15772298 |
| 61 | neurotransmitter transport (GO:0006836) | 3.15659798 |
| 62 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.15401871 |
| 63 | regulation of neurotransmitter levels (GO:0001505) | 3.15302652 |
| 64 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.15279523 |
| 65 | cilium organization (GO:0044782) | 3.13699871 |
| 66 | eye photoreceptor cell differentiation (GO:0001754) | 3.12409546 |
| 67 | photoreceptor cell differentiation (GO:0046530) | 3.12409546 |
| 68 | long-chain fatty-acyl-CoA biosynthetic process (GO:0035338) | 3.11805972 |
| 69 | negative regulation of peptidyl-threonine phosphorylation (GO:0010801) | 3.11492334 |
| 70 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.09145293 |
| 71 | astrocyte development (GO:0014002) | 3.07884591 |
| 72 | cilium assembly (GO:0042384) | 3.07867243 |
| 73 | neuron recognition (GO:0008038) | 3.07305132 |
| 74 | long-chain fatty-acyl-CoA metabolic process (GO:0035336) | 3.02714648 |
| 75 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.01660493 |
| 76 | glutamate receptor signaling pathway (GO:0007215) | 3.01298615 |
| 77 | regulation of microtubule-based movement (GO:0060632) | 2.99647182 |
| 78 | vocalization behavior (GO:0071625) | 2.99542221 |
| 79 | regulation of neurotransmitter secretion (GO:0046928) | 2.99101533 |
| 80 | regulation of synaptic plasticity (GO:0048167) | 2.99070042 |
| 81 | protein localization to synapse (GO:0035418) | 2.98569182 |
| 82 | positive regulation of oligodendrocyte differentiation (GO:0048714) | 2.97124354 |
| 83 | intraciliary transport (GO:0042073) | 2.96965598 |
| 84 | regulation of inclusion body assembly (GO:0090083) | 2.96890974 |
| 85 | neuron-neuron synaptic transmission (GO:0007270) | 2.95782736 |
| 86 | regulation of synapse structural plasticity (GO:0051823) | 2.95331887 |
| 87 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.95231223 |
| 88 | left/right axis specification (GO:0070986) | 2.94585599 |
| 89 | sterol biosynthetic process (GO:0016126) | 2.94201342 |
| 90 | righting reflex (GO:0060013) | 2.93648621 |
| 91 | glutamate secretion (GO:0014047) | 2.93555760 |
| 92 | positive regulation of action potential (GO:0045760) | 2.92885270 |
| 93 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.92102007 |
| 94 | gamma-aminobutyric acid transport (GO:0015812) | 2.88948260 |
| 95 | regulation of ARF protein signal transduction (GO:0032012) | 2.86335694 |
| 96 | synaptic transmission, glutamatergic (GO:0035249) | 2.85869420 |
| 97 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.85293129 |
| 98 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.85246428 |
| 99 | response to redox state (GO:0051775) | 2.85196785 |
| 100 | negative regulation of synaptic transmission (GO:0050805) | 2.84594740 |
| 101 | regulation of neurotransmitter transport (GO:0051588) | 2.84318986 |
| 102 | creatine metabolic process (GO:0006600) | 2.82712531 |
| 103 | mechanosensory behavior (GO:0007638) | 2.81374555 |
| 104 | microtubule-based movement (GO:0007018) | 2.79231939 |
| 105 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.78525762 |
| 106 | isoprenoid biosynthetic process (GO:0008299) | 2.78073094 |
| 107 | postsynaptic membrane organization (GO:0001941) | 2.77899826 |
| 108 | diterpenoid biosynthetic process (GO:0016102) | 2.76879608 |
| 109 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.75848675 |
| 110 | regulation of dopamine metabolic process (GO:0042053) | 2.75632755 |
| 111 | regulation of catecholamine metabolic process (GO:0042069) | 2.75632755 |
| 112 | neuron remodeling (GO:0016322) | 2.75253943 |
| 113 | negative regulation of dendrite morphogenesis (GO:0050774) | 2.74765269 |
| 114 | sodium ion homeostasis (GO:0055078) | 2.72831395 |
| 115 | sperm capacitation (GO:0048240) | 2.72470245 |
| 116 | regulation of cell communication by electrical coupling (GO:0010649) | 2.71710846 |
| 117 | protein palmitoylation (GO:0018345) | 2.71345626 |
| 118 | long-term synaptic potentiation (GO:0060291) | 2.71140440 |
| 119 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.70592353 |
| 120 | membrane assembly (GO:0071709) | 2.70588853 |
| 121 | ethanol metabolic process (GO:0006067) | 2.70113740 |
| 122 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.68684058 |
| 123 | import into cell (GO:0098657) | 2.66984050 |
| 124 | regulation of postsynaptic membrane potential (GO:0060078) | 2.66975711 |
| 125 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 2.66710805 |
| 126 | negative regulation of B cell mediated immunity (GO:0002713) | 2.66676729 |
| 127 | negative regulation of immunoglobulin mediated immune response (GO:0002890) | 2.66676729 |
| 128 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.66527202 |
| 129 | fatty-acyl-CoA biosynthetic process (GO:0046949) | 2.65027851 |
| 130 | positive regulation of synapse assembly (GO:0051965) | 2.64453841 |
| 131 | startle response (GO:0001964) | 2.64283673 |
| 132 | membrane tubulation (GO:0097320) | 2.62448545 |
| 133 | axonal fasciculation (GO:0007413) | 2.61399893 |
| 134 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.60410990 |
| 135 | auditory behavior (GO:0031223) | 2.60132808 |
| 136 | positive regulation of epidermal growth factor-activated receptor activity (GO:0045741) | 2.59312918 |
| 137 | fatty-acyl-CoA metabolic process (GO:0035337) | 2.58040802 |
| 138 | C4-dicarboxylate transport (GO:0015740) | 2.58006374 |
| 139 | magnesium ion transport (GO:0015693) | 2.57699266 |
| 140 | neuronal ion channel clustering (GO:0045161) | 2.57687272 |
| 141 | dendritic spine morphogenesis (GO:0060997) | 2.55815896 |
| 142 | regulation of glutamate secretion (GO:0014048) | 2.55505944 |
| 143 | regulation of glutamate receptor signaling pathway (GO:1900449) | 2.55122808 |
| 144 | nerve growth factor signaling pathway (GO:0038180) | 2.54172354 |
| 145 | myelination in peripheral nervous system (GO:0022011) | 2.53823192 |
| 146 | peripheral nervous system axon ensheathment (GO:0032292) | 2.53823192 |
| 147 | synaptic vesicle maturation (GO:0016188) | 2.53336616 |
| 148 | amyloid precursor protein metabolic process (GO:0042982) | 2.52881460 |
| 149 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.51608417 |
| 150 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.50640651 |
| 151 | locomotory exploration behavior (GO:0035641) | 2.50201303 |
| 152 | cellular response to epinephrine stimulus (GO:0071872) | 2.49964507 |
| 153 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.48476438 |
| 154 | adult locomotory behavior (GO:0008344) | 2.47926617 |
| 155 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.47792160 |
| 156 | regulation of lipoprotein metabolic process (GO:0050746) | 2.47207752 |
| 157 | acidic amino acid transport (GO:0015800) | 2.47124771 |
| 158 | axonemal dynein complex assembly (GO:0070286) | 10.1075879 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.10029885 |
| 2 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.93214350 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.82394672 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.72644833 |
| 5 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.65413619 |
| 6 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.64388587 |
| 7 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.29202241 |
| 8 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.28586172 |
| 9 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.27246138 |
| 10 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.26968436 |
| 11 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.26651778 |
| 12 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.26651778 |
| 13 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 2.26110825 |
| 14 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.23239684 |
| 15 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.21704265 |
| 16 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.21549820 |
| 17 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.14006990 |
| 18 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.10121294 |
| 19 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.03017986 |
| 20 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.02657926 |
| 21 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.93701549 |
| 22 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.93638553 |
| 23 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.91333948 |
| 24 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.90924360 |
| 25 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.89700751 |
| 26 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.84933612 |
| 27 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.83294750 |
| 28 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.82769476 |
| 29 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 1.75490400 |
| 30 | * POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.70867052 |
| 31 | VDR_22108803_ChIP-Seq_LS180_Human | 1.67174557 |
| 32 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.65525422 |
| 33 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.65469430 |
| 34 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.64585240 |
| 35 | P300_19829295_ChIP-Seq_ESCs_Human | 1.62435675 |
| 36 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.56661459 |
| 37 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.56396948 |
| 38 | FUS_26573619_Chip-Seq_HEK293_Human | 1.56323774 |
| 39 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.54828250 |
| 40 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.54410931 |
| 41 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.53423972 |
| 42 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.52948323 |
| 43 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.52562164 |
| 44 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.52521712 |
| 45 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.51762455 |
| 46 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.49850264 |
| 47 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.47870241 |
| 48 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.46847292 |
| 49 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.46373099 |
| 50 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.44346361 |
| 51 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.41881929 |
| 52 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.40849367 |
| 53 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.36875893 |
| 54 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.33720887 |
| 55 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.26505171 |
| 56 | STAT3_23295773_ChIP-Seq_U87_Human | 1.25058761 |
| 57 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.24526101 |
| 58 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.22226874 |
| 59 | AR_19668381_ChIP-Seq_PC3_Human | 1.21829588 |
| 60 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.19562214 |
| 61 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.19323583 |
| 62 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.18957143 |
| 63 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.18303952 |
| 64 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.18039947 |
| 65 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.17960596 |
| 66 | * BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.17065381 |
| 67 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.17026363 |
| 68 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.15457813 |
| 69 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.15119910 |
| 70 | TCF4_23295773_ChIP-Seq_U87_Human | 1.14759393 |
| 71 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.14466357 |
| 72 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.13717258 |
| 73 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.13477616 |
| 74 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.13430801 |
| 75 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.12385118 |
| 76 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.11804551 |
| 77 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.11483582 |
| 78 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.09884617 |
| 79 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.09614046 |
| 80 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.09614046 |
| 81 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.09596557 |
| 82 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.09126344 |
| 83 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.08100163 |
| 84 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.06653032 |
| 85 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.05926107 |
| 86 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.05868599 |
| 87 | * AR_25329375_ChIP-Seq_VCAP_Human | 1.05597314 |
| 88 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.05358282 |
| 89 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.05218918 |
| 90 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.03907503 |
| 91 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.03683540 |
| 92 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.03447677 |
| 93 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.03447677 |
| 94 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.03044957 |
| 95 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.03022138 |
| 96 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.02750910 |
| 97 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.02689152 |
| 98 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.01745650 |
| 99 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.01455479 |
| 100 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.00697940 |
| 101 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.00126144 |
| 102 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.99968932 |
| 103 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.99838340 |
| 104 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.99182972 |
| 105 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.98912670 |
| 106 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.98846206 |
| 107 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.97782956 |
| 108 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.97485278 |
| 109 | JUN_21703547_ChIP-Seq_K562_Human | 0.96536743 |
| 110 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.96176678 |
| 111 | * SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.96139181 |
| 112 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.96121173 |
| 113 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.95992810 |
| 114 | KDM2B_26808549_Chip-Seq_REH_Human | 0.95890169 |
| 115 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.95862998 |
| 116 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.95555743 |
| 117 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.95472086 |
| 118 | TP53_16413492_ChIP-PET_HCT116_Human | 0.95360513 |
| 119 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.95277504 |
| 120 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.94882133 |
| 121 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94109427 |
| 122 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.93000959 |
| 123 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 0.92515832 |
| 124 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 0.92407902 |
| 125 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.92326270 |
| 126 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.90999865 |
| 127 | RXR_22108803_ChIP-Seq_LS180_Human | 0.88223195 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 4.93058623 |
| 2 | MP0000920_abnormal_myelination | 3.82192836 |
| 3 | MP0004859_abnormal_synaptic_plasticity | 3.65124949 |
| 4 | MP0004270_analgesia | 3.53354418 |
| 5 | MP0002064_seizures | 2.89778213 |
| 6 | MP0003635_abnormal_synaptic_transmissio | 2.87633210 |
| 7 | MP0001529_abnormal_vocalization | 2.85681626 |
| 8 | MP0002272_abnormal_nervous_system | 2.83722019 |
| 9 | MP0001486_abnormal_startle_reflex | 2.78782221 |
| 10 | MP0009745_abnormal_behavioral_response | 2.71124081 |
| 11 | MP0009046_muscle_twitch | 2.70027301 |
| 12 | MP0008875_abnormal_xenobiotic_pharmacok | 2.59775690 |
| 13 | MP0003329_amyloid_beta_deposits | 2.55037874 |
| 14 | MP0001905_abnormal_dopamine_level | 2.49519174 |
| 15 | MP0003690_abnormal_glial_cell | 2.44967731 |
| 16 | MP0004885_abnormal_endolymph | 2.34488683 |
| 17 | MP0003950_abnormal_plasma_membrane | 2.33974765 |
| 18 | MP0005171_absent_coat_pigmentation | 2.27535095 |
| 19 | MP0002063_abnormal_learning/memory/cond | 2.26251611 |
| 20 | MP0002572_abnormal_emotion/affect_behav | 2.25927861 |
| 21 | MP0004142_abnormal_muscle_tone | 2.24545263 |
| 22 | MP0005423_abnormal_somatic_nervous | 2.15925228 |
| 23 | MP0002734_abnormal_mechanical_nocicepti | 2.14651123 |
| 24 | MP0001968_abnormal_touch/_nociception | 2.13165465 |
| 25 | MP0004742_abnormal_vestibular_system | 2.10345305 |
| 26 | MP0002653_abnormal_ependyma_morphology | 2.09384119 |
| 27 | MP0003136_yellow_coat_color | 2.02867770 |
| 28 | MP0000778_abnormal_nervous_system | 2.02027037 |
| 29 | MP0001440_abnormal_grooming_behavior | 2.01449088 |
| 30 | MP0002736_abnormal_nociception_after | 1.95147834 |
| 31 | MP0003634_abnormal_glial_cell | 1.88459129 |
| 32 | MP0001485_abnormal_pinna_reflex | 1.81573823 |
| 33 | MP0002067_abnormal_sensory_capabilities | 1.76340345 |
| 34 | MP0005409_darkened_coat_color | 1.75494327 |
| 35 | MP0001501_abnormal_sleep_pattern | 1.63558016 |
| 36 | MP0002229_neurodegeneration | 1.63073518 |
| 37 | MP0001970_abnormal_pain_threshold | 1.62732988 |
| 38 | MP0005386_behavior/neurological_phenoty | 1.61585308 |
| 39 | MP0004924_abnormal_behavior | 1.61585308 |
| 40 | MP0002735_abnormal_chemical_nociception | 1.57859742 |
| 41 | MP0008569_lethality_at_weaning | 1.51869852 |
| 42 | MP0003632_abnormal_nervous_system | 1.51784672 |
| 43 | MP0002733_abnormal_thermal_nociception | 1.49776771 |
| 44 | MP0003631_nervous_system_phenotype | 1.49679769 |
| 45 | MP0003633_abnormal_nervous_system | 1.48492727 |
| 46 | MP0004043_abnormal_pH_regulation | 1.46157179 |
| 47 | MP0005410_abnormal_fertilization | 1.45482604 |
| 48 | MP0000955_abnormal_spinal_cord | 1.45019211 |
| 49 | MP0002882_abnormal_neuron_morphology | 1.42883909 |
| 50 | MP0005551_abnormal_eye_electrophysiolog | 1.42533568 |
| 51 | MP0005646_abnormal_pituitary_gland | 1.42209742 |
| 52 | MP0002066_abnormal_motor_capabilities/c | 1.40974687 |
| 53 | MP0002822_catalepsy | 1.39956320 |
| 54 | MP0001963_abnormal_hearing_physiology | 1.31357949 |
| 55 | MP0004133_heterotaxia | 1.27677947 |
| 56 | MP0002557_abnormal_social/conspecific_i | 1.22185942 |
| 57 | MP0000604_amyloidosis | 1.21959228 |
| 58 | MP0003787_abnormal_imprinting | 1.18650125 |
| 59 | MP0001502_abnormal_circadian_rhythm | 1.17101840 |
| 60 | MP0009780_abnormal_chondrocyte_physiolo | 1.15379177 |
| 61 | MP0002638_abnormal_pupillary_reflex | 1.13661707 |
| 62 | MP0005645_abnormal_hypothalamus_physiol | 1.13496647 |
| 63 | MP0002184_abnormal_innervation | 1.12757848 |
| 64 | MP0006276_abnormal_autonomic_nervous | 1.07223251 |
| 65 | MP0002752_abnormal_somatic_nervous | 1.06217260 |
| 66 | MP0002909_abnormal_adrenal_gland | 1.04094812 |
| 67 | MP0005167_abnormal_blood-brain_barrier | 1.03866255 |
| 68 | MP0000462_abnormal_digestive_system | 0.99905443 |
| 69 | MP0002152_abnormal_brain_morphology | 0.96255951 |
| 70 | MP0001188_hyperpigmentation | 0.96136788 |
| 71 | MP0004145_abnormal_muscle_electrophysio | 0.93332324 |
| 72 | MP0004134_abnormal_chest_morphology | 0.93203908 |
| 73 | MP0003075_altered_response_to | 0.92921754 |
| 74 | MP0000566_synostosis | 0.92723154 |
| 75 | MP0008260_abnormal_autophagy | 0.92351291 |
| 76 | MP0001346_abnormal_lacrimal_gland | 0.92248507 |
| 77 | MP0001984_abnormal_olfaction | 0.91062440 |
| 78 | MP0000026_abnormal_inner_ear | 0.90134198 |
| 79 | MP0004811_abnormal_neuron_physiology | 0.89775291 |
| 80 | MP0004147_increased_porphyrin_level | 0.86586261 |
| 81 | MP0001765_abnormal_ion_homeostasis | 0.84588900 |
| 82 | MP0010386_abnormal_urinary_bladder | 0.83137031 |
| 83 | MP0003183_abnormal_peptide_metabolism | 0.81623399 |
| 84 | MP0001299_abnormal_eye_distance/ | 0.81298289 |
| 85 | MP0010678_abnormal_skin_adnexa | 0.80195872 |
| 86 | MP0003938_abnormal_ear_development | 0.79114277 |
| 87 | MP0005195_abnormal_posterior_eye | 0.78760004 |
| 88 | MP0005623_abnormal_meninges_morphology | 0.78579501 |
| 89 | MP0008872_abnormal_physiological_respon | 0.78057318 |
| 90 | MP0004381_abnormal_hair_follicle | 0.77088863 |
| 91 | MP0000631_abnormal_neuroendocrine_gland | 0.76839031 |
| 92 | MP0001177_atelectasis | 0.76367510 |
| 93 | MP0001664_abnormal_digestion | 0.75806734 |
| 94 | MP0000747_muscle_weakness | 0.74219120 |
| 95 | MP0000569_abnormal_digit_pigmentation | 0.73211372 |
| 96 | MP0005253_abnormal_eye_physiology | 0.70179940 |
| 97 | MP0005187_abnormal_penis_morphology | 0.69990068 |
| 98 | MP0003806_abnormal_nucleotide_metabolis | 0.67715895 |
| 99 | MP0000383_abnormal_hair_follicle | 0.67169943 |
| 100 | MP0008874_decreased_physiological_sensi | 0.66071275 |
| 101 | MP0003045_fibrosis | 0.65351248 |
| 102 | MP0004085_abnormal_heartbeat | 0.64431489 |
| 103 | MP0004215_abnormal_myocardial_fiber | 0.64265028 |
| 104 | MP0002168_other_aberrant_phenotype | 0.63791276 |
| 105 | MP0002090_abnormal_vision | 0.63215209 |
| 106 | MP0003137_abnormal_impulse_conducting | 0.62463633 |
| 107 | MP0002069_abnormal_eating/drinking_beha | 0.61411499 |
| 108 | MP0005451_abnormal_body_composition | 0.60551122 |
| 109 | MP0006072_abnormal_retinal_apoptosis | 0.60346185 |
| 110 | MP0003879_abnormal_hair_cell | 0.59549227 |
| 111 | MP0001986_abnormal_taste_sensitivity | 0.58306380 |
| 112 | MP0001943_abnormal_respiration | 0.58043566 |
| 113 | MP0004036_abnormal_muscle_relaxation | 0.57652988 |
| 114 | MP0001661_extended_life_span | 0.57403432 |
| 115 | MP0004858_abnormal_nervous_system | 0.56919090 |
| 116 | MP0002160_abnormal_reproductive_system | 0.56365740 |
| 117 | MP0003195_calcinosis | 0.56160670 |
| 118 | MP0008789_abnormal_olfactory_epithelium | 0.56135172 |
| 119 | MP0000639_abnormal_adrenal_gland | 0.55905854 |
| 120 | MP0005165_increased_susceptibility_to | 0.55513210 |
| 121 | MP0002876_abnormal_thyroid_physiology | 0.55387023 |
| 122 | MP0000751_myopathy | 0.55200250 |
| 123 | MP0002277_abnormal_respiratory_mucosa | 0.53244024 |
| 124 | MP0005394_taste/olfaction_phenotype | 0.52794600 |
| 125 | MP0005499_abnormal_olfactory_system | 0.52794600 |
| 126 | MP0003956_abnormal_body_size | 0.51739672 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 9.40803412 |
| 2 | Abnormal respiratory motile cilium morphology (HP:0005938) | 8.57046938 |
| 3 | Abnormal respiratory epithelium morphology (HP:0012253) | 8.57046938 |
| 4 | Abnormal respiratory motile cilium physiology (HP:0012261) | 8.31752972 |
| 5 | Abnormal ciliary motility (HP:0012262) | 8.17716330 |
| 6 | Rhinitis (HP:0012384) | 7.78402304 |
| 7 | Chronic bronchitis (HP:0004469) | 5.89071438 |
| 8 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 5.79706911 |
| 9 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 5.79706911 |
| 10 | Neurofibrillary tangles (HP:0002185) | 5.64333670 |
| 11 | Bronchiectasis (HP:0002110) | 5.48726694 |
| 12 | Focal motor seizures (HP:0011153) | 4.77930172 |
| 13 | Nasal polyposis (HP:0100582) | 4.68664471 |
| 14 | Abnormality of the corticospinal tract (HP:0002492) | 4.43248855 |
| 15 | Cerebral inclusion bodies (HP:0100314) | 4.37597383 |
| 16 | Myokymia (HP:0002411) | 3.95294231 |
| 17 | Sensory axonal neuropathy (HP:0003390) | 3.87069363 |
| 18 | Abnormality of the nasal mucosa (HP:0000433) | 3.80981835 |
| 19 | Epileptic encephalopathy (HP:0200134) | 3.72163947 |
| 20 | Parakeratosis (HP:0001036) | 3.71254650 |
| 21 | Peripheral hypomyelination (HP:0007182) | 3.68809041 |
| 22 | Supranuclear gaze palsy (HP:0000605) | 3.60693962 |
| 23 | Hyperventilation (HP:0002883) | 3.40493948 |
| 24 | Dysmetria (HP:0001310) | 3.29726902 |
| 25 | Spastic gait (HP:0002064) | 3.28920589 |
| 26 | Termporal pattern (HP:0011008) | 3.28185596 |
| 27 | Insidious onset (HP:0003587) | 3.28185596 |
| 28 | True hermaphroditism (HP:0010459) | 3.20821675 |
| 29 | Infertility (HP:0000789) | 3.20460034 |
| 30 | Atonic seizures (HP:0010819) | 3.15042649 |
| 31 | Increased serum pyruvate (HP:0003542) | 3.09369452 |
| 32 | Abnormality of glycolysis (HP:0004366) | 3.09369452 |
| 33 | Bronchitis (HP:0012387) | 3.08422607 |
| 34 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 3.08139561 |
| 35 | Recurrent sinusitis (HP:0011108) | 3.02408507 |
| 36 | Focal seizures (HP:0007359) | 2.99294726 |
| 37 | Pancreatic fibrosis (HP:0100732) | 2.96827462 |
| 38 | Scanning speech (HP:0002168) | 2.92012938 |
| 39 | Occipital encephalocele (HP:0002085) | 2.90773409 |
| 40 | Retinal dysplasia (HP:0007973) | 2.90736563 |
| 41 | Chronic sinusitis (HP:0011109) | 2.86431466 |
| 42 | Onion bulb formation (HP:0003383) | 2.83515290 |
| 43 | Pheochromocytoma (HP:0002666) | 2.81681196 |
| 44 | Clumsiness (HP:0002312) | 2.81252457 |
| 45 | Intention tremor (HP:0002080) | 2.81193952 |
| 46 | Ankle clonus (HP:0011448) | 2.73740733 |
| 47 | Thickened helices (HP:0000391) | 2.73482556 |
| 48 | Leukodystrophy (HP:0002415) | 2.71190526 |
| 49 | Recurrent otitis media (HP:0000403) | 2.71079812 |
| 50 | Male infertility (HP:0003251) | 2.65258468 |
| 51 | Cerebral hypomyelination (HP:0006808) | 2.63182368 |
| 52 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.60275526 |
| 53 | Aplasia of the phalanges of the hand (HP:0009802) | 2.60275526 |
| 54 | Aplasia involving bones of the extremities (HP:0009825) | 2.60275526 |
| 55 | Broad-based gait (HP:0002136) | 2.57515410 |
| 56 | Abnormal auditory evoked potentials (HP:0006958) | 2.54326204 |
| 57 | Neuroendocrine neoplasm (HP:0100634) | 2.53713156 |
| 58 | Dialeptic seizures (HP:0011146) | 2.50190059 |
| 59 | Cystic liver disease (HP:0006706) | 2.48703260 |
| 60 | Alacrima (HP:0000522) | 2.47687184 |
| 61 | Chronic otitis media (HP:0000389) | 2.45316222 |
| 62 | Hyperactive renin-angiotensin system (HP:0000841) | 2.41078597 |
| 63 | Acute necrotizing encephalopathy (HP:0006965) | 2.33456679 |
| 64 | Molar tooth sign on MRI (HP:0002419) | 2.32645297 |
| 65 | Abnormality of midbrain morphology (HP:0002418) | 2.32645297 |
| 66 | Akinesia (HP:0002304) | 2.31528915 |
| 67 | Lower limb muscle weakness (HP:0007340) | 2.29452896 |
| 68 | Autoamputation (HP:0001218) | 2.28378495 |
| 69 | Hypokalemic alkalosis (HP:0001949) | 2.28190738 |
| 70 | Pancreatic cysts (HP:0001737) | 2.27716072 |
| 71 | Absence seizures (HP:0002121) | 2.23944040 |
| 72 | Slow saccadic eye movements (HP:0000514) | 2.23094574 |
| 73 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.22132519 |
| 74 | Absent septum pellucidum (HP:0001331) | 2.21832593 |
| 75 | Action tremor (HP:0002345) | 2.21738024 |
| 76 | Dysdiadochokinesis (HP:0002075) | 2.20862355 |
| 77 | Megalencephaly (HP:0001355) | 2.19774749 |
| 78 | Gaze-evoked nystagmus (HP:0000640) | 2.18459778 |
| 79 | Anteriorly placed anus (HP:0001545) | 2.17394422 |
| 80 | Cerebral hemorrhage (HP:0001342) | 2.16794818 |
| 81 | Nephronophthisis (HP:0000090) | 2.14593634 |
| 82 | Progressive cerebellar ataxia (HP:0002073) | 2.14191898 |
| 83 | Methylmalonic acidemia (HP:0002912) | 2.12968207 |
| 84 | Hemiparesis (HP:0001269) | 2.11763636 |
| 85 | Postural instability (HP:0002172) | 2.11468817 |
| 86 | Generalized tonic-clonic seizures (HP:0002069) | 2.10886257 |
| 87 | Hypoplastic pelvis (HP:0008839) | 2.10565865 |
| 88 | Abnormality of binocular vision (HP:0011514) | 2.10222367 |
| 89 | Diplopia (HP:0000651) | 2.10222367 |
| 90 | Split foot (HP:0001839) | 2.09891563 |
| 91 | Congenital primary aphakia (HP:0007707) | 2.09812149 |
| 92 | Chronic hepatic failure (HP:0100626) | 2.08398843 |
| 93 | Generalized myoclonic seizures (HP:0002123) | 2.08026908 |
| 94 | Torticollis (HP:0000473) | 2.06985882 |
| 95 | Truncal ataxia (HP:0002078) | 2.06610242 |
| 96 | Obstructive sleep apnea (HP:0002870) | 2.06159233 |
| 97 | Congenital ichthyosiform erythroderma (HP:0007431) | 2.05442661 |
| 98 | Vaginal atresia (HP:0000148) | 2.04205793 |
| 99 | Atelectasis (HP:0100750) | 2.01641968 |
| 100 | Hyperaldosteronism (HP:0000859) | 2.00458768 |
| 101 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.99696345 |
| 102 | Decreased lacrimation (HP:0000633) | 1.98963855 |
| 103 | Genital tract atresia (HP:0001827) | 1.97624246 |
| 104 | Renal salt wasting (HP:0000127) | 1.96505980 |
| 105 | Metabolic alkalosis (HP:0200114) | 1.96163808 |
| 106 | Urinary urgency (HP:0000012) | 1.95613349 |
| 107 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.95407110 |
| 108 | Increased circulating renin level (HP:0000848) | 1.93509643 |
| 109 | Progressive macrocephaly (HP:0004481) | 1.93321360 |
| 110 | Blue irides (HP:0000635) | 1.91938596 |
| 111 | Progressive inability to walk (HP:0002505) | 1.90092452 |
| 112 | Humeroradial synostosis (HP:0003041) | 1.89156267 |
| 113 | Synostosis involving the elbow (HP:0003938) | 1.89156267 |
| 114 | Postaxial foot polydactyly (HP:0001830) | 1.89119448 |
| 115 | Gait imbalance (HP:0002141) | 1.88934749 |
| 116 | Spastic tetraparesis (HP:0001285) | 1.87509036 |
| 117 | Mitochondrial inheritance (HP:0001427) | 1.87195679 |
| 118 | Acute encephalopathy (HP:0006846) | 1.86453295 |
| 119 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.85582538 |
| 120 | Widely spaced teeth (HP:0000687) | 1.85475371 |
| 121 | Morphological abnormality of the inner ear (HP:0011390) | 1.84185403 |
| 122 | Anxiety (HP:0000739) | 1.83933040 |
| 123 | Spastic paraparesis (HP:0002313) | 1.83423693 |
| 124 | Bell-shaped thorax (HP:0001591) | 1.82956687 |
| 125 | Abnormality of the septum pellucidum (HP:0007375) | 1.82929560 |
| 126 | Segmental peripheral demyelination/remyelination (HP:0003481) | 1.82602360 |
| 127 | Abnormal eating behavior (HP:0100738) | 1.82035134 |
| 128 | Medial flaring of the eyebrow (HP:0010747) | 1.81347326 |
| 129 | Decreased circulating renin level (HP:0003351) | 1.80001604 |
| 130 | Neuronal loss in central nervous system (HP:0002529) | 1.79600632 |
| 131 | CNS hypomyelination (HP:0003429) | 1.79194023 |
| 132 | Nephrogenic diabetes insipidus (HP:0009806) | 1.79152168 |
| 133 | Febrile seizures (HP:0002373) | 1.78885605 |
| 134 | Poor speech (HP:0002465) | 1.77509259 |
| 135 | Abnormality of renin-angiotensin system (HP:0000847) | 1.77388244 |
| 136 | Partial agenesis of the corpus callosum (HP:0001338) | 1.77302688 |
| 137 | Limb dystonia (HP:0002451) | 1.76156332 |
| 138 | Hemiplegia (HP:0002301) | 1.76034712 |
| 139 | Ventricular fibrillation (HP:0001663) | 1.74838388 |
| 140 | Absent speech (HP:0001344) | 1.73945559 |
| 141 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.73844443 |
| 142 | Absent/shortened dynein arms (HP:0200106) | 1.73844443 |
| 143 | Drooling (HP:0002307) | 1.72625681 |
| 144 | Excessive salivation (HP:0003781) | 1.72625681 |
| 145 | Focal dystonia (HP:0004373) | 1.72123700 |
| 146 | Papilledema (HP:0001085) | 1.71149779 |
| 147 | Sleep apnea (HP:0010535) | 1.70363816 |
| 148 | Fetal akinesia sequence (HP:0001989) | 1.69120987 |
| 149 | Depression (HP:0000716) | 1.67659788 |
| 150 | Male pseudohermaphroditism (HP:0000037) | 1.65271185 |
| 151 | Congenital hepatic fibrosis (HP:0002612) | 1.63664112 |
| 152 | Absent frontal sinuses (HP:0002688) | 1.62967005 |
| 153 | Abnormality of the renal medulla (HP:0100957) | 1.62733847 |
| 154 | Status epilepticus (HP:0002133) | 1.61297076 |
| 155 | Asplenia (HP:0001746) | 1.60589345 |
| 156 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.60430243 |
| 157 | Tubulointerstitial nephritis (HP:0001970) | 1.59236887 |
| 158 | Anencephaly (HP:0002323) | 1.59044247 |
| 159 | Dysmetric saccades (HP:0000641) | 1.57993882 |
| 160 | Impaired smooth pursuit (HP:0007772) | 1.57234983 |
| 161 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.55977244 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | STK39 | 4.65467391 |
| 2 | OXSR1 | 3.98440385 |
| 3 | CASK | 3.75388812 |
| 4 | EPHA4 | 2.91868105 |
| 5 | CDK19 | 2.86362259 |
| 6 | MAPKAPK5 | 2.17273924 |
| 7 | BCR | 2.16785546 |
| 8 | PBK | 2.11942092 |
| 9 | TNIK | 2.09065017 |
| 10 | CAMKK1 | 2.07980175 |
| 11 | PRPF4B | 2.05706079 |
| 12 | EPHB1 | 2.04457228 |
| 13 | PNCK | 2.03276221 |
| 14 | PKN1 | 2.03028174 |
| 15 | MUSK | 1.95005978 |
| 16 | NTRK3 | 1.85146515 |
| 17 | WNK4 | 1.82237305 |
| 18 | PRKD3 | 1.66548915 |
| 19 | MAP3K2 | 1.65760201 |
| 20 | CAMK2B | 1.61710146 |
| 21 | FGFR2 | 1.58260152 |
| 22 | NTRK1 | 1.56298205 |
| 23 | UHMK1 | 1.52833100 |
| 24 | MET | 1.50678089 |
| 25 | WNK1 | 1.50264568 |
| 26 | FGR | 1.47101860 |
| 27 | MAP2K7 | 1.41303526 |
| 28 | MARK1 | 1.40181003 |
| 29 | NEK6 | 1.39632774 |
| 30 | CSNK1G3 | 1.37805652 |
| 31 | MAP3K4 | 1.37502281 |
| 32 | PAK6 | 1.36904783 |
| 33 | SGK2 | 1.36459526 |
| 34 | SGK494 | 1.29032310 |
| 35 | SGK223 | 1.29032310 |
| 36 | CAMKK2 | 1.28164246 |
| 37 | CSNK1G2 | 1.26710183 |
| 38 | LIMK1 | 1.26256340 |
| 39 | CSNK1A1L | 1.25028683 |
| 40 | ROCK2 | 1.24694674 |
| 41 | CAMK2D | 1.20872954 |
| 42 | CAMK2A | 1.19136997 |
| 43 | NTRK2 | 1.12638621 |
| 44 | CDK5 | 1.12386011 |
| 45 | PLK2 | 1.12003123 |
| 46 | FRK | 1.11998775 |
| 47 | MAP3K9 | 1.05613460 |
| 48 | ARAF | 1.05612345 |
| 49 | MST4 | 1.04637380 |
| 50 | CSNK1G1 | 1.00531387 |
| 51 | CAMK2G | 0.98796210 |
| 52 | SGK3 | 0.95924622 |
| 53 | CAMK1 | 0.95573353 |
| 54 | STK38 | 0.93053749 |
| 55 | PHKG2 | 0.91360577 |
| 56 | PHKG1 | 0.91360577 |
| 57 | CDK14 | 0.90371700 |
| 58 | PRKCE | 0.87585733 |
| 59 | CDK15 | 0.86225089 |
| 60 | CDK18 | 0.84603875 |
| 61 | DAPK2 | 0.83379461 |
| 62 | MAPK13 | 0.80906753 |
| 63 | BMPR1B | 0.79548187 |
| 64 | PAK3 | 0.77404878 |
| 65 | MINK1 | 0.76920315 |
| 66 | GRK5 | 0.76030950 |
| 67 | MAPK10 | 0.75507143 |
| 68 | CDK11A | 0.75344449 |
| 69 | PTK2B | 0.75324581 |
| 70 | ICK | 0.72270277 |
| 71 | CLK1 | 0.71159923 |
| 72 | DAPK1 | 0.70747029 |
| 73 | BMPR2 | 0.70631922 |
| 74 | SIK2 | 0.70337473 |
| 75 | KSR2 | 0.70247232 |
| 76 | MAP3K13 | 0.69882051 |
| 77 | TESK2 | 0.69600411 |
| 78 | PRKCQ | 0.69286860 |
| 79 | TYRO3 | 0.67046304 |
| 80 | MARK2 | 0.66219702 |
| 81 | GRK7 | 0.66062269 |
| 82 | MAP3K12 | 0.65006724 |
| 83 | EPHA2 | 0.64951470 |
| 84 | MAPKAPK3 | 0.63971589 |
| 85 | PDPK1 | 0.63935223 |
| 86 | MAP2K4 | 0.63714041 |
| 87 | PRKCG | 0.62520172 |
| 88 | FES | 0.61200772 |
| 89 | EPHA3 | 0.60828120 |
| 90 | NME1 | 0.60739649 |
| 91 | ADRBK2 | 0.60655410 |
| 92 | RPS6KA3 | 0.59574358 |
| 93 | RIPK4 | 0.59031126 |
| 94 | DYRK2 | 0.58716678 |
| 95 | ERBB2 | 0.57847555 |
| 96 | ERBB4 | 0.57556671 |
| 97 | PRKCZ | 0.56812878 |
| 98 | TNK2 | 0.52916809 |
| 99 | STK11 | 0.52054094 |
| 100 | FYN | 0.51667787 |
| 101 | MAPK7 | 0.51571051 |
| 102 | ALK | 0.51000372 |
| 103 | CAMK4 | 0.50976996 |
| 104 | PRKCA | 0.50944636 |
| 105 | PRKG1 | 0.49731311 |
| 106 | ROCK1 | 0.49393531 |
| 107 | AKT3 | 0.47487612 |
| 108 | DYRK1A | 0.46866298 |
| 109 | PRKCH | 0.46653686 |
| 110 | CSNK1A1 | 0.45922397 |
| 111 | PRKD1 | 0.45695492 |
| 112 | MAP3K7 | 0.44926449 |
| 113 | LATS2 | 0.43380950 |
| 114 | SGK1 | 0.43042260 |
| 115 | RAF1 | 0.42775702 |
| 116 | PRKACB | 0.42535912 |
| 117 | RET | 0.42330511 |
| 118 | PIK3CA | 0.42325279 |
| 119 | MAPK15 | 0.42286303 |
| 120 | PINK1 | 0.41657676 |
| 121 | PRKACA | 0.40226668 |
| 122 | RIPK1 | 0.39964317 |
| 123 | CDK3 | 0.38983761 |
| 124 | CSNK1D | 0.38717867 |
| 125 | PDK1 | 0.37022869 |
| 126 | CAMK1G | 0.36822779 |
| 127 | MAPK12 | 0.36676851 |
| 128 | ADRBK1 | 0.35216864 |
| 129 | RPS6KB1 | 0.32561358 |
| 130 | PRKCB | 0.30575428 |
| 131 | STK24 | 0.30041077 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 3.69922295 |
| 2 | Fatty acid elongation_Homo sapiens_hsa00062 | 3.27056508 |
| 3 | Steroid biosynthesis_Homo sapiens_hsa00100 | 3.11369101 |
| 4 | Nicotine addiction_Homo sapiens_hsa05033 | 2.66923263 |
| 5 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.61129832 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.42595032 |
| 7 | Ether lipid metabolism_Homo sapiens_hsa00565 | 2.34830802 |
| 8 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.27547391 |
| 9 | GABAergic synapse_Homo sapiens_hsa04727 | 2.17505292 |
| 10 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.10697648 |
| 11 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.09396148 |
| 12 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.07719413 |
| 13 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.04849479 |
| 14 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.04785536 |
| 15 | Morphine addiction_Homo sapiens_hsa05032 | 1.94513667 |
| 16 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.89344979 |
| 17 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.72871492 |
| 18 | Circadian entrainment_Homo sapiens_hsa04713 | 1.70312625 |
| 19 | Parkinsons disease_Homo sapiens_hsa05012 | 1.66242277 |
| 20 | Alzheimers disease_Homo sapiens_hsa05010 | 1.65333913 |
| 21 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.60918270 |
| 22 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.55006386 |
| 23 | Long-term depression_Homo sapiens_hsa04730 | 1.53345906 |
| 24 | Salivary secretion_Homo sapiens_hsa04970 | 1.50982101 |
| 25 | Axon guidance_Homo sapiens_hsa04360 | 1.46220607 |
| 26 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.44000917 |
| 27 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.41533584 |
| 28 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.39675204 |
| 29 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.39519216 |
| 30 | Cocaine addiction_Homo sapiens_hsa05030 | 1.35560969 |
| 31 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.33524865 |
| 32 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.32262788 |
| 33 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.30109184 |
| 34 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.29959319 |
| 35 | Long-term potentiation_Homo sapiens_hsa04720 | 1.27310726 |
| 36 | Olfactory transduction_Homo sapiens_hsa04740 | 1.24564835 |
| 37 | Taste transduction_Homo sapiens_hsa04742 | 1.23360535 |
| 38 | Circadian rhythm_Homo sapiens_hsa04710 | 1.21525244 |
| 39 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.17388397 |
| 40 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.17162833 |
| 41 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.16596221 |
| 42 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.16075602 |
| 43 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.12932122 |
| 44 | Histidine metabolism_Homo sapiens_hsa00340 | 1.12442198 |
| 45 | Renin secretion_Homo sapiens_hsa04924 | 1.11228554 |
| 46 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.10149865 |
| 47 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.03054763 |
| 48 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.01644404 |
| 49 | Phototransduction_Homo sapiens_hsa04744 | 1.01320998 |
| 50 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.00739253 |
| 51 | Protein export_Homo sapiens_hsa03060 | 1.00235308 |
| 52 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.00191224 |
| 53 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.99825600 |
| 54 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.98459418 |
| 55 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.94894944 |
| 56 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.94797729 |
| 57 | Insulin secretion_Homo sapiens_hsa04911 | 0.94411512 |
| 58 | Huntingtons disease_Homo sapiens_hsa05016 | 0.91945571 |
| 59 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.91193945 |
| 60 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.89444297 |
| 61 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.88781995 |
| 62 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.85517276 |
| 63 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.84085731 |
| 64 | ABC transporters_Homo sapiens_hsa02010 | 0.79696542 |
| 65 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.78332266 |
| 66 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.78313555 |
| 67 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.77681307 |
| 68 | Gap junction_Homo sapiens_hsa04540 | 0.76137322 |
| 69 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.75977512 |
| 70 | Bile secretion_Homo sapiens_hsa04976 | 0.75802943 |
| 71 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.74993164 |
| 72 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.73151173 |
| 73 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.72852574 |
| 74 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.72570258 |
| 75 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.69850599 |
| 76 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.69444348 |
| 77 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.69063922 |
| 78 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.68770933 |
| 79 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.68579709 |
| 80 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.67258199 |
| 81 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.67085444 |
| 82 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.66682214 |
| 83 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.65251632 |
| 84 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.64492217 |
| 85 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.63895744 |
| 86 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.62840245 |
| 87 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.60969064 |
| 88 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.60547318 |
| 89 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.60064634 |
| 90 | Glioma_Homo sapiens_hsa05214 | 0.59201593 |
| 91 | Mineral absorption_Homo sapiens_hsa04978 | 0.56519363 |
| 92 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.56279280 |
| 93 | Phagosome_Homo sapiens_hsa04145 | 0.53400817 |
| 94 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.53009928 |
| 95 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.52862727 |
| 96 | Tight junction_Homo sapiens_hsa04530 | 0.51136408 |
| 97 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.51114309 |
| 98 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.49500538 |
| 99 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.48944692 |
| 100 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.48681097 |
| 101 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.48549266 |
| 102 | Melanogenesis_Homo sapiens_hsa04916 | 0.48518769 |
| 103 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.46673644 |
| 104 | Endocytosis_Homo sapiens_hsa04144 | 0.46356476 |
| 105 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.44692360 |
| 106 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.43945068 |
| 107 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.42634796 |
| 108 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.42510354 |
| 109 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.41707419 |
| 110 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.40610691 |
| 111 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.39146098 |
| 112 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.37314442 |
| 113 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.36736259 |
| 114 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.35973762 |
| 115 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.35090875 |
| 116 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.34557633 |
| 117 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.33880957 |
| 118 | Alcoholism_Homo sapiens_hsa05034 | 0.33506767 |
| 119 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.33404756 |
| 120 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.32158278 |
| 121 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.31962125 |
| 122 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.30441874 |
| 123 | Prion diseases_Homo sapiens_hsa05020 | 0.29013815 |
| 124 | Retinol metabolism_Homo sapiens_hsa00830 | 0.27681621 |
| 125 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.25177567 |
| 126 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.23645027 |

