OMP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Olfactory marker protein is uniquely associated with the mature olfactory receptor neurons in many vertebrate species from fish to man. The OMP gene structure and protein sequence are highly conserved between mouse, rat and human. Results of the mouse knockout studies show that OMP-null mice are compromised in their ability to respond to odor stimuli, and that OMP represents a novel modulatory component of the odor detection/signal transduction cascade. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)7.23004803
2adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.96253889
3regulation of cilium movement (GO:0003352)6.33947056
4regulation of chromatin binding (GO:0035561)5.86076377
5protein polyglutamylation (GO:0018095)5.79682369
6axonemal dynein complex assembly (GO:0070286)5.77227132
7axoneme assembly (GO:0035082)5.71476216
8antibacterial humoral response (GO:0019731)5.37335177
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.11288402
10cilium morphogenesis (GO:0060271)5.08338015
11auditory receptor cell differentiation (GO:0042491)5.06652511
12antimicrobial humoral response (GO:0019730)4.96473111
13intraciliary transport (GO:0042073)4.95971592
14innate immune response in mucosa (GO:0002227)4.80471167
15activation of protein kinase A activity (GO:0034199)4.77781418
16cilium movement (GO:0003341)4.76814775
17negative regulation of cytosolic calcium ion concentration (GO:0051481)4.47007032
18detection of calcium ion (GO:0005513)4.34816976
19dopamine receptor signaling pathway (GO:0007212)4.31687230
20adipose tissue development (GO:0060612)4.20164097
21cAMP biosynthetic process (GO:0006171)4.08284603
22response to caffeine (GO:0031000)4.07674678
23olfactory bulb development (GO:0021772)4.07197472
24behavioral response to cocaine (GO:0048148)4.07149933
25microtubule severing (GO:0051013)3.97350865
26mucosal immune response (GO:0002385)3.92693373
27regulation of sodium ion transmembrane transporter activity (GO:2000649)3.81182911
28regulation of microtubule-based movement (GO:0060632)3.76808163
29organ or tissue specific immune response (GO:0002251)3.71112053
30cellular response to glucagon stimulus (GO:0071377)3.66070245
31natural killer cell mediated cytotoxicity (GO:0042267)3.62998706
32natural killer cell mediated immunity (GO:0002228)3.62998706
33protein heterotetramerization (GO:0051290)3.62772960
34epithelial cilium movement (GO:0003351)3.57916695
35neuron cell-cell adhesion (GO:0007158)3.55811225
36photoreceptor cell maintenance (GO:0045494)3.54803607
37oligosaccharide catabolic process (GO:0009313)3.47421948
38phosphorelay signal transduction system (GO:0000160)3.45663218
39regulation of sodium ion transmembrane transport (GO:1902305)3.44882029
40membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.38754920
41axonal fasciculation (GO:0007413)3.38635421
42mating behavior (GO:0007617)3.34890666
43negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.34853210
44regulation of heart rate by cardiac conduction (GO:0086091)3.33469099
45calcium-mediated signaling using intracellular calcium source (GO:0035584)3.32427195
46negative regulation of microtubule polymerization (GO:0031115)3.31125068
47microtubule bundle formation (GO:0001578)3.29971270
48potassium ion transmembrane transport (GO:0071805)3.26200115
49cellular potassium ion transport (GO:0071804)3.26200115
50cellular copper ion homeostasis (GO:0006878)3.22382150
51magnesium ion transport (GO:0015693)3.18067866
52response to amphetamine (GO:0001975)3.14816990
53negative regulation of complement activation (GO:0045916)3.13932254
54brain morphogenesis (GO:0048854)3.10009689
55negative regulation of astrocyte differentiation (GO:0048712)3.08047462
56regulation of protein kinase A signaling (GO:0010738)3.04364712
57hair cell differentiation (GO:0035315)3.03635280
58* sensory perception of smell (GO:0007608)23.3059303
59chemical homeostasis within a tissue (GO:0048875)2.99695197
60ovulation cycle (GO:0042698)2.98459908
61inner ear receptor cell differentiation (GO:0060113)2.97941445
62membrane repolarization during action potential (GO:0086011)2.97891950
63potassium ion homeostasis (GO:0055075)2.97194566
64glycogen catabolic process (GO:0005980)2.95997603
65regulation of cell communication by electrical coupling (GO:0010649)2.95706563
66potassium ion transport (GO:0006813)2.92186741
67positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.90916956
68negative regulation of transcription regulatory region DNA binding (GO:2000678)2.90345012
69atrial cardiac muscle cell action potential (GO:0086014)2.90108106
70cellular response to electrical stimulus (GO:0071257)2.86240412
71regulation of sodium ion transport (GO:0002028)2.86225841
72response to glucagon (GO:0033762)2.86079983
73facial nerve structural organization (GO:0021612)2.84461395
74melanosome transport (GO:0032402)2.84240219
75glutamate secretion (GO:0014047)2.83605062
76left/right axis specification (GO:0070986)2.80004664
77relaxation of cardiac muscle (GO:0055119)2.79398321
78cilium or flagellum-dependent cell motility (GO:0001539)2.76256497
79glucan catabolic process (GO:0009251)2.76040389
80cardiac conduction (GO:0061337)2.75879665
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.75779775
82connective tissue development (GO:0061448)2.75612298
83nucleoside diphosphate phosphorylation (GO:0006165)2.74519920
84cAMP metabolic process (GO:0046058)2.73971021
85positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.73150741
86sensory perception of taste (GO:0050909)2.71953472
87cilium assembly (GO:0042384)2.71726148
88establishment of melanosome localization (GO:0032401)2.71067722
89adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)2.69564250
90neuronal action potential (GO:0019228)2.68473060
91response to gravity (GO:0009629)2.67883829
92pigment granule transport (GO:0051904)2.67355120
93negative regulation of protein activation cascade (GO:2000258)2.64752223
94calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.62038649
95potassium ion export (GO:0071435)2.61336347
96phototransduction, visible light (GO:0007603)2.61242864
97forebrain neuron development (GO:0021884)2.60873514
98* sensory perception of chemical stimulus (GO:0007606)13.3422934
99protein insertion into membrane (GO:0051205)13.0670194
100protein localization to cilium (GO:0061512)10.9158562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.35538708
2ZNF263_19887448_ChIP-Seq_K562_Human3.91947325
3DROSHA_22980978_ChIP-Seq_HELA_Human3.03980609
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.01932921
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.90592152
6GBX2_23144817_ChIP-Seq_PC3_Human2.79377245
7TAF15_26573619_Chip-Seq_HEK293_Human2.55929862
8* BMI1_19503595_ChIP-Seq_MEFsC_Mouse2.01747946
9EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92404165
10RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92404165
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88727530
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83672755
13ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.81507021
14EED_16625203_ChIP-ChIP_MESCs_Mouse1.78835693
15ESR1_20079471_ChIP-ChIP_T-47D_Human1.77408194
16CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75739024
17SRY_22984422_ChIP-ChIP_TESTIS_Rat1.71126765
18AHR_22903824_ChIP-Seq_MCF-7_Human1.70270265
19GATA1_26923725_Chip-Seq_HPCs_Mouse1.69432176
20GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.68954552
21LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67527532
22KDM2B_26808549_Chip-Seq_K562_Human1.66680474
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66009180
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63381433
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54747738
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54632270
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54632270
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50050438
29ARNT_22903824_ChIP-Seq_MCF-7_Human1.48925377
30REST_21632747_ChIP-Seq_MESCs_Mouse1.48255954
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47691842
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45680617
33RNF2_27304074_Chip-Seq_NSC_Mouse1.44419917
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41524237
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41265910
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40876913
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36091590
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35637111
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34521145
40TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.32966101
41SMAD4_21741376_ChIP-Seq_EPCs_Human1.29817126
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28347854
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27249037
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.22587833
45SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21661484
46* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21254890
47RING1B_27294783_Chip-Seq_ESCs_Mouse1.21139802
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21025921
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21025775
50GATA3_27048872_Chip-Seq_THYMUS_Human1.19244846
51MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18276881
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17826447
53OCT4_20526341_ChIP-Seq_ESCs_Human1.13764419
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12676828
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11433223
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09394530
57P300_19829295_ChIP-Seq_ESCs_Human1.09187577
58SMAD4_21799915_ChIP-Seq_A2780_Human1.08624715
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.08615113
60* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08402324
61* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08157569
62* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07742901
63SMAD4_21741376_ChIP-Seq_HESCs_Human1.07376247
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.06820090
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.05989290
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.05807771
67SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03505885
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02303057
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.01533353
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01203900
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00371321
72* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98983710
73PRDM14_20953172_ChIP-Seq_ESCs_Human0.98140595
74CTCF_20526341_ChIP-Seq_ESCs_Human0.95993890
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93495827
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93379429
77TCF4_22108803_ChIP-Seq_LS180_Human0.93322531
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92711673
79CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92024426
80EZH2_27304074_Chip-Seq_ESCs_Mouse0.91983409
81MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91284021
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91260623
83KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91224989
84SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91110157
85KLF5_25053715_ChIP-Seq_YYC3_Human0.90834130
86STAT1_20625510_ChIP-Seq_HELA_Human0.89639374
87TAF2_19829295_ChIP-Seq_ESCs_Human0.89541100
88E2F1_20622854_ChIP-Seq_HELA_Human0.88484032
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.88268573
90ERG_21242973_ChIP-ChIP_JURKAT_Human0.88015932
91CEBPB_22108803_ChIP-Seq_LS180_Human0.87860733
92GF1_26923725_Chip-Seq_HPCs_Mouse0.87059777
93CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86289995
94ESR2_21235772_ChIP-Seq_MCF-7_Human0.85811669
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.85303834
96ERA_21632823_ChIP-Seq_H3396_Human0.84934014
97TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83308935
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.80969062
99NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80305137
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.79625407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium4.56252840
2MP0005394_taste/olfaction_phenotype4.32385817
3MP0005499_abnormal_olfactory_system4.32385817
4MP0003806_abnormal_nucleotide_metabolis3.03385631
5MP0005645_abnormal_hypothalamus_physiol2.71585031
6MP0003878_abnormal_ear_physiology2.55766500
7MP0005377_hearing/vestibular/ear_phenot2.55766500
8MP0002184_abnormal_innervation2.29271493
9MP0001485_abnormal_pinna_reflex2.26059937
10MP0001984_abnormal_olfaction15.9295858
11MP0002822_catalepsy1.66985159
12MP0001542_abnormal_bone_strength1.56142701
13MP0002160_abnormal_reproductive_system1.50181978
14MP0002734_abnormal_mechanical_nocicepti1.46021149
15MP0005367_renal/urinary_system_phenotyp1.39770537
16MP0000516_abnormal_urinary_system1.39770537
17MP0002928_abnormal_bile_duct1.32802266
18MP0001486_abnormal_startle_reflex1.31374498
19MP0008875_abnormal_xenobiotic_pharmacok1.30014535
20MP0002557_abnormal_social/conspecific_i1.24325950
21MP0002653_abnormal_ependyma_morphology1.23892213
22* MP0002752_abnormal_somatic_nervous1.22045773
23MP0002272_abnormal_nervous_system1.19136948
24MP0005084_abnormal_gallbladder_morpholo1.19020487
25MP0000372_irregular_coat_pigmentation1.16845604
26MP0002233_abnormal_nose_morphology1.16159605
27MP0010234_abnormal_vibrissa_follicle1.07062828
28MP0005410_abnormal_fertilization1.05635582
29MP0000778_abnormal_nervous_system0.96098903
30MP0003635_abnormal_synaptic_transmissio0.94690477
31MP0005646_abnormal_pituitary_gland0.93305463
32* MP0002882_abnormal_neuron_morphology0.91849863
33MP0003252_abnormal_bile_duct0.89454199
34MP0002877_abnormal_melanocyte_morpholog0.88676742
35MP0005551_abnormal_eye_electrophysiolog0.84345896
36MP0003880_abnormal_central_pattern0.82667299
37MP0004742_abnormal_vestibular_system0.79517495
38MP0009333_abnormal_splenocyte_physiolog0.77345584
39MP0002063_abnormal_learning/memory/cond0.77111741
40MP0000003_abnormal_adipose_tissue0.76395261
41MP0004811_abnormal_neuron_physiology0.75491429
42MP0002909_abnormal_adrenal_gland0.74746637
43MP0001293_anophthalmia0.73488473
44MP0004147_increased_porphyrin_level0.73468159
45MP0002229_neurodegeneration0.71547977
46MP0004133_heterotaxia0.67866112
47MP0002572_abnormal_emotion/affect_behav0.66175458
48MP0001970_abnormal_pain_threshold0.65418462
49MP0004270_analgesia0.64274087
50MP0005389_reproductive_system_phenotype0.63687370
51MP0005187_abnormal_penis_morphology0.63667481
52MP0006276_abnormal_autonomic_nervous0.63514448
53MP0001963_abnormal_hearing_physiology0.63426300
54* MP0002152_abnormal_brain_morphology0.63335532
55MP0004858_abnormal_nervous_system0.58572786
56MP0003634_abnormal_glial_cell0.57107628
57MP0000026_abnormal_inner_ear0.55761138
58MP0002064_seizures0.54820957
59MP0005623_abnormal_meninges_morphology0.54661350
60MP0002067_abnormal_sensory_capabilities0.54063445
61MP0000538_abnormal_urinary_bladder0.52892348
62MP0006082_CNS_inflammation0.52430924
63MP0005195_abnormal_posterior_eye0.47323658
64MP0004859_abnormal_synaptic_plasticity0.46074211
65MP0002896_abnormal_bone_mineralization0.46022374
66MP0009745_abnormal_behavioral_response0.45321817
67MP0010386_abnormal_urinary_bladder0.45027250
68MP0010030_abnormal_orbit_morphology0.44242488
69MP0003633_abnormal_nervous_system0.44106890
70MP0003075_altered_response_to0.43682478
71MP0001188_hyperpigmentation0.43080410
72MP0002751_abnormal_autonomic_nervous0.42455102
73MP0000049_abnormal_middle_ear0.41700138
74MP0003861_abnormal_nervous_system0.41265534
75MP0000631_abnormal_neuroendocrine_gland0.40869065
76MP0005423_abnormal_somatic_nervous0.40756759
77MP0002092_abnormal_eye_morphology0.40137742
78MP0008874_decreased_physiological_sensi0.39252467
79MP0001501_abnormal_sleep_pattern0.39126467
80MP0003195_calcinosis0.38880596
81MP0003942_abnormal_urinary_system0.38820438
82MP0003879_abnormal_hair_cell0.38621399
83MP0005174_abnormal_tail_pigmentation0.37874584
84MP0005165_increased_susceptibility_to0.35358059
85MP0003693_abnormal_embryo_hatching0.35012659
86MP0005058_abnormal_lysosome_morphology0.34945802
87MP0001299_abnormal_eye_distance/0.33480220
88MP0005365_abnormal_bile_salt0.32207311
89MP0002295_abnormal_pulmonary_circulatio0.31140180
90MP0002082_postnatal_lethality0.31014597
91MP0010770_preweaning_lethality0.31014597
92MP0006036_abnormal_mitochondrial_physio0.29965928
93MP0006035_abnormal_mitochondrial_morpho0.29964145
94MP0002066_abnormal_motor_capabilities/c0.29956395
95MP0001270_distended_abdomen0.29037987
96MP0009046_muscle_twitch0.28843057
97MP0002938_white_spotting0.28136865
98MP0002102_abnormal_ear_morphology0.27961828
99MP0004782_abnormal_surfactant_physiolog0.26543631
100MP0010769_abnormal_survival0.26088132

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.36336950
2Retinal dysplasia (HP:0007973)7.56194603
3Abnormal respiratory motile cilium physiology (HP:0012261)7.12483658
4Rhinitis (HP:0012384)6.34582340
5Abnormality of macular pigmentation (HP:0008002)6.19140864
6Limb dystonia (HP:0002451)6.03307994
7Abnormal respiratory motile cilium morphology (HP:0005938)5.95983173
8Abnormal respiratory epithelium morphology (HP:0012253)5.95983173
9Abnormal ciliary motility (HP:0012262)5.86462096
10Chronic bronchitis (HP:0004469)5.40516580
11Molar tooth sign on MRI (HP:0002419)5.06180016
12Abnormality of midbrain morphology (HP:0002418)5.06180016
13Palpitations (HP:0001962)5.04774814
14Bifid tongue (HP:0010297)5.04644171
15Bony spicule pigmentary retinopathy (HP:0007737)4.66610255
16Dysphonia (HP:0001618)4.58807605
17Atonic seizures (HP:0010819)4.37999076
18Hypothermia (HP:0002045)4.37039533
19Bronchiectasis (HP:0002110)3.66560266
20Absent/shortened dynein arms (HP:0200106)3.59334097
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.59334097
22Chronic hepatic failure (HP:0100626)3.59036867
23Syncope (HP:0001279)3.57852059
24Gait imbalance (HP:0002141)3.42096618
25Abnormality of dentin (HP:0010299)3.35870616
26Short nail (HP:0001799)3.35307255
27Anosmia (HP:0000458)3.34508777
28Congenital primary aphakia (HP:0007707)3.32410020
29Hypochromic microcytic anemia (HP:0004840)3.26802084
30Abolished electroretinogram (ERG) (HP:0000550)3.24652982
31Torticollis (HP:0000473)3.23022359
32Nephrogenic diabetes insipidus (HP:0009806)3.12092519
33Poikilocytosis (HP:0004447)3.12019914
34Medial flaring of the eyebrow (HP:0010747)3.01359098
35Febrile seizures (HP:0002373)2.96395892
36Postaxial hand polydactyly (HP:0001162)2.93072589
37Central scotoma (HP:0000603)2.91660973
38Abnormality of sodium homeostasis (HP:0010931)2.88879187
39Craniofacial dystonia (HP:0012179)2.85174279
40Occipital encephalocele (HP:0002085)2.79980719
41Absence seizures (HP:0002121)2.75552754
42Prolonged QT interval (HP:0001657)2.74383186
43Vaginal atresia (HP:0000148)2.67988218
44Nephronophthisis (HP:0000090)2.60334461
45True hermaphroditism (HP:0010459)2.59488190
46Focal dystonia (HP:0004373)2.59202918
47Genital tract atresia (HP:0001827)2.54705241
48Insidious onset (HP:0003587)2.51019337
49Termporal pattern (HP:0011008)2.51019337
50Xerostomia (HP:0000217)2.50232970
51Poor coordination (HP:0002370)2.49987988
52Chronic sinusitis (HP:0011109)2.48062932
53Pancreatic fibrosis (HP:0100732)2.42584177
54Oculomotor apraxia (HP:0000657)2.36432726
55Nasal polyposis (HP:0100582)2.35247081
56Constricted visual fields (HP:0001133)2.34291136
57Aplasia/Hypoplasia of the lens (HP:0008063)2.28553011
58Recurrent otitis media (HP:0000403)2.22283410
59Hyperglycinemia (HP:0002154)2.18466202
60Recurrent sinusitis (HP:0011108)2.15180539
61Renal hypoplasia (HP:0000089)2.14221276
62Cystic liver disease (HP:0006706)2.11910094
63Retinitis pigmentosa (HP:0000510)2.07468773
64Pancreatic cysts (HP:0001737)2.06988652
65Bronchitis (HP:0012387)2.06740559
66Abnormality of the dental root (HP:0006486)2.05795592
67Taurodontia (HP:0000679)2.05795592
68Abnormality of permanent molar morphology (HP:0011071)2.05795592
69Restlessness (HP:0000711)2.04432268
70Sudden death (HP:0001699)2.03560673
71Dialeptic seizures (HP:0011146)2.03308719
72Agitation (HP:0000713)2.00108747
73Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98734796
74Complete atrioventricular canal defect (HP:0001674)1.98298084
75Abnormality of the renal medulla (HP:0100957)1.95487463
76Vacuolated lymphocytes (HP:0001922)1.94885654
77Abnormality of the dental pulp (HP:0006479)1.93639998
78Bradycardia (HP:0001662)1.93269150
79Abnormality of molar (HP:0011077)1.92397530
80Abnormality of molar morphology (HP:0011070)1.92397530
81Median cleft lip (HP:0000161)1.90367226
82Myokymia (HP:0002411)1.89351031
83Furrowed tongue (HP:0000221)1.86235060
84Conjunctival hamartoma (HP:0100780)1.82498629
85Abnormal biliary tract physiology (HP:0012439)1.82168743
86Bile duct proliferation (HP:0001408)1.82168743
87Diminished motivation (HP:0000745)1.81829700
88Abnormality of the nasal mucosa (HP:0000433)1.80009594
89Abnormality of the diencephalon (HP:0010662)1.78608665
90Apathy (HP:0000741)1.74928683
91Focal seizures (HP:0007359)1.74456697
92Abnormal EKG (HP:0003115)1.73400402
93Tubulointerstitial nephritis (HP:0001970)1.70911134
94Impaired pain sensation (HP:0007328)1.70896371
95Abnormality of pain sensation (HP:0010832)1.70896371
96Primary atrial arrhythmia (HP:0001692)1.70860924
97Sclerocornea (HP:0000647)1.70433293
98Aganglionic megacolon (HP:0002251)1.68303165
99Absent eyebrow (HP:0002223)1.67555534
100Erectile abnormalities (HP:0100639)1.66725890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.89922355
2PHKG25.46424172
3PHKG15.46424172
4ERBB33.80266543
5PAK33.32488865
6CAMK2D2.75647827
7CAMK2B2.57143691
8MAPKAPK32.30628346
9SIK22.26674125
10STK242.18838099
11STK38L2.15939904
12CAMK2G2.09519177
13EEF2K2.08359967
14DAPK22.06063107
15NUAK12.03157653
16ARAF1.94925318
17STK161.86237624
18CSNK1A1L1.85616958
19ICK1.69413833
20CSNK1G31.67528687
21TRIB31.49846164
22RIPK11.47566535
23CSNK1G11.43853263
24CSNK1G21.40608003
25FRK1.27295602
26HIPK21.24130473
27ILK1.16141447
28PRKCG1.10198408
29CAMK1G1.08822532
30STK391.07947715
31DAPK11.07554610
32DYRK31.00843507
33CAMKK20.99989274
34RPS6KA20.95435053
35CAMK1D0.89941397
36GRK60.86285303
37PIM20.84113192
38CAMK2A0.80426723
39STK380.79666762
40MAP3K100.75453438
41TYRO30.75291851
42DYRK1A0.75022508
43MAP3K20.74449621
44GRK50.72871297
45DYRK1B0.70075093
46MINK10.61783044
47STK110.59933161
48MARK10.58192568
49PRPF4B0.54619192
50SRPK10.53490705
51MAP3K40.48556622
52TRPM70.47435939
53CAMKK10.46542445
54MAPK130.46112999
55TNK20.44035018
56MAPKAPK20.42720768
57TGFBR20.42647878
58MUSK0.42437802
59MAP3K70.40634960
60AKT30.40493433
61SGK4940.40447903
62SGK2230.40447903
63MAPKAPK50.40252237
64MARK20.38113933
65MAP2K20.36983401
66NLK0.36593092
67PRKAA20.35785606
68DAPK30.33925255
69PRKCQ0.33619963
70MAP2K70.33609654
71CASK0.33535802
72BRAF0.33131561
73PRKCZ0.32972046
74WNK40.32016064
75CDK50.31642494
76TESK10.31237065
77AKT20.29982796
78FYN0.29310761
79TTK0.28372463
80CAMK40.28221080
81PNCK0.25898774
82LMTK20.25274424
83CDK30.24888552
84EGFR0.24505003
85IRAK10.23831480
86NTRK10.23732422
87PLK20.23462519
88PRKACG0.23431607
89CDK90.23358272
90ROCK20.22864049
91OXSR10.22585644
92MAPK70.22453787
93PTK2B0.22350625
94PRKD10.22028738
95PRKACA0.21301642
96FER0.20320519
97INSR0.19967132
98MAP2K40.19849051
99PRKAA10.19681467
100AURKA0.19454686

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.89761072
2Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.89509479
3Olfactory transduction_Homo sapiens_hsa0474012.2942551
4Taste transduction_Homo sapiens_hsa047421.82957368
5Morphine addiction_Homo sapiens_hsa050321.72620078
6Circadian entrainment_Homo sapiens_hsa047131.64069589
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62810919
8Insulin secretion_Homo sapiens_hsa049111.47143892
9cAMP signaling pathway_Homo sapiens_hsa040241.41741472
10Histidine metabolism_Homo sapiens_hsa003401.41053026
11Dopaminergic synapse_Homo sapiens_hsa047281.38967252
12Gastric acid secretion_Homo sapiens_hsa049711.36841818
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36286461
14Salivary secretion_Homo sapiens_hsa049701.33756267
15Vibrio cholerae infection_Homo sapiens_hsa051101.32865759
16Ovarian steroidogenesis_Homo sapiens_hsa049131.28709423
17Bile secretion_Homo sapiens_hsa049761.26457382
18Thyroid hormone synthesis_Homo sapiens_hsa049181.24780567
19Cholinergic synapse_Homo sapiens_hsa047251.23772013
20GABAergic synapse_Homo sapiens_hsa047271.20839610
21Glutamatergic synapse_Homo sapiens_hsa047241.19694450
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16776261
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16331002
24beta-Alanine metabolism_Homo sapiens_hsa004101.08083226
25cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04788836
26Other glycan degradation_Homo sapiens_hsa005110.97436231
27Alcoholism_Homo sapiens_hsa050340.96608814
28Amphetamine addiction_Homo sapiens_hsa050310.93040601
29Calcium signaling pathway_Homo sapiens_hsa040200.90624434
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88025225
31Sphingolipid metabolism_Homo sapiens_hsa006000.87189690
32Synaptic vesicle cycle_Homo sapiens_hsa047210.87078867
33Estrogen signaling pathway_Homo sapiens_hsa049150.86726482
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86001556
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79290177
36GnRH signaling pathway_Homo sapiens_hsa049120.78334654
37Renin secretion_Homo sapiens_hsa049240.77832091
38Parkinsons disease_Homo sapiens_hsa050120.77828162
39Fatty acid biosynthesis_Homo sapiens_hsa000610.76643312
40Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75437530
41Melanogenesis_Homo sapiens_hsa049160.69962206
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68116358
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67269942
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66876846
45Collecting duct acid secretion_Homo sapiens_hsa049660.66660141
46Sulfur metabolism_Homo sapiens_hsa009200.63569214
47Glucagon signaling pathway_Homo sapiens_hsa049220.63466322
48ABC transporters_Homo sapiens_hsa020100.62947090
49Sulfur relay system_Homo sapiens_hsa041220.62192904
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.60002522
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59883501
52Oxytocin signaling pathway_Homo sapiens_hsa049210.52692052
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.51278792
54Gap junction_Homo sapiens_hsa045400.51252590
55Pancreatic secretion_Homo sapiens_hsa049720.51234370
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49553889
57Alzheimers disease_Homo sapiens_hsa050100.49338246
58Arachidonic acid metabolism_Homo sapiens_hsa005900.48250979
59Long-term potentiation_Homo sapiens_hsa047200.47387609
60Purine metabolism_Homo sapiens_hsa002300.45814965
61Cocaine addiction_Homo sapiens_hsa050300.44933740
62N-Glycan biosynthesis_Homo sapiens_hsa005100.44482281
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44458392
64Serotonergic synapse_Homo sapiens_hsa047260.43945022
65Dilated cardiomyopathy_Homo sapiens_hsa054140.41914582
66Oxidative phosphorylation_Homo sapiens_hsa001900.41854996
67Systemic lupus erythematosus_Homo sapiens_hsa053220.39798831
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38903906
69Rap1 signaling pathway_Homo sapiens_hsa040150.38443502
70Pyruvate metabolism_Homo sapiens_hsa006200.38308082
71Cardiac muscle contraction_Homo sapiens_hsa042600.37093189
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36479381
73Insulin signaling pathway_Homo sapiens_hsa049100.35318038
74Oocyte meiosis_Homo sapiens_hsa041140.31903881
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.31781137
76Starch and sucrose metabolism_Homo sapiens_hsa005000.30878522
77Axon guidance_Homo sapiens_hsa043600.30224113
78Caffeine metabolism_Homo sapiens_hsa002320.29628121
79Ras signaling pathway_Homo sapiens_hsa040140.29008228
80Chemical carcinogenesis_Homo sapiens_hsa052040.27591646
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27545480
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27079330
83Huntingtons disease_Homo sapiens_hsa050160.23233995
84Amoebiasis_Homo sapiens_hsa051460.21794864
85Glioma_Homo sapiens_hsa052140.21014246
86Propanoate metabolism_Homo sapiens_hsa006400.20936527
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19040555
88Arginine and proline metabolism_Homo sapiens_hsa003300.18842257
89Chemokine signaling pathway_Homo sapiens_hsa040620.18136550
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.16882279
91Notch signaling pathway_Homo sapiens_hsa043300.16794107
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16654051
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16632883
94Glutathione metabolism_Homo sapiens_hsa004800.16003517
95Nicotine addiction_Homo sapiens_hsa050330.15500300
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14919143
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13494617
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.12920265
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.10633698
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10464731

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