ONECUT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.52987221
2L-phenylalanine catabolic process (GO:0006559)7.52987221
3L-phenylalanine metabolic process (GO:0006558)7.14324040
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.14324040
5aromatic amino acid family catabolic process (GO:0009074)7.00460807
6indole-containing compound catabolic process (GO:0042436)6.62396211
7indolalkylamine catabolic process (GO:0046218)6.62396211
8tryptophan catabolic process (GO:0006569)6.62396211
9kynurenine metabolic process (GO:0070189)6.41943864
10tryptophan metabolic process (GO:0006568)6.21103344
11bile acid biosynthetic process (GO:0006699)6.13864387
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.11662191
13alpha-linolenic acid metabolic process (GO:0036109)5.79414812
14glyoxylate metabolic process (GO:0046487)5.78163618
15urea metabolic process (GO:0019627)5.67558434
16urea cycle (GO:0000050)5.67558434
17flavonoid metabolic process (GO:0009812)5.53065470
18regulation of protein activation cascade (GO:2000257)5.52041849
19complement activation, alternative pathway (GO:0006957)5.48505228
20negative regulation of fibrinolysis (GO:0051918)5.48334592
21regulation of fibrinolysis (GO:0051917)5.40597771
22protein carboxylation (GO:0018214)5.37865089
23peptidyl-glutamic acid carboxylation (GO:0017187)5.37865089
24high-density lipoprotein particle remodeling (GO:0034375)5.32839203
25bile acid metabolic process (GO:0008206)5.21917259
26nitrogen cycle metabolic process (GO:0071941)5.21507805
27regulation of complement activation (GO:0030449)5.15486635
28pyrimidine nucleobase catabolic process (GO:0006208)5.13434886
29aromatic amino acid family metabolic process (GO:0009072)5.05070420
30sulfur amino acid catabolic process (GO:0000098)5.03155089
31cysteine metabolic process (GO:0006534)5.02365752
32serine family amino acid catabolic process (GO:0009071)4.95729513
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.95580161
34coenzyme catabolic process (GO:0009109)4.92723822
35homocysteine metabolic process (GO:0050667)4.83432530
36indolalkylamine metabolic process (GO:0006586)4.70073644
37reverse cholesterol transport (GO:0043691)4.69328828
38regulation of triglyceride catabolic process (GO:0010896)4.66658021
39epoxygenase P450 pathway (GO:0019373)4.65898052
40cellular biogenic amine catabolic process (GO:0042402)4.64198682
41amine catabolic process (GO:0009310)4.64198682
42alpha-amino acid catabolic process (GO:1901606)4.62616179
43triglyceride homeostasis (GO:0070328)4.62065776
44acylglycerol homeostasis (GO:0055090)4.62065776
45protein-lipid complex remodeling (GO:0034368)4.61808330
46macromolecular complex remodeling (GO:0034367)4.61808330
47plasma lipoprotein particle remodeling (GO:0034369)4.61808330
48tyrosine metabolic process (GO:0006570)4.59109763
49regulation of cholesterol esterification (GO:0010872)4.57168938
50regulation of plasminogen activation (GO:0010755)4.53217523
51bile acid and bile salt transport (GO:0015721)4.52194978
52phospholipid efflux (GO:0033700)4.49570429
53amino-acid betaine metabolic process (GO:0006577)4.46042420
54proline metabolic process (GO:0006560)4.45971241
55lysine metabolic process (GO:0006553)4.45832247
56lysine catabolic process (GO:0006554)4.45832247
57nucleobase catabolic process (GO:0046113)4.42367344
58imidazole-containing compound metabolic process (GO:0052803)4.38598312
59drug metabolic process (GO:0017144)4.38208828
60cellular ketone body metabolic process (GO:0046950)4.37328232
61negative regulation of sterol transport (GO:0032372)4.34105654
62negative regulation of cholesterol transport (GO:0032375)4.34105654
63omega-hydroxylase P450 pathway (GO:0097267)4.28777477
64glycine metabolic process (GO:0006544)4.26806111
65cellular glucuronidation (GO:0052695)4.26695958
66cellular amino acid catabolic process (GO:0009063)4.22381816
67benzene-containing compound metabolic process (GO:0042537)4.16276900
68plasma lipoprotein particle clearance (GO:0034381)4.16168898
69glutamate metabolic process (GO:0006536)4.13756229
70regulation of bile acid biosynthetic process (GO:0070857)4.11497560
71ethanol oxidation (GO:0006069)4.08918064
72cellular modified amino acid catabolic process (GO:0042219)4.08471491
73cholesterol efflux (GO:0033344)4.07714266
74fibrinolysis (GO:0042730)4.06143008
75drug catabolic process (GO:0042737)4.03061117
76dicarboxylic acid biosynthetic process (GO:0043650)4.01293687
77serine family amino acid metabolic process (GO:0009069)3.98373411
78cofactor catabolic process (GO:0051187)3.96645827
79arginine metabolic process (GO:0006525)3.95196441
80intestinal absorption (GO:0050892)3.90575132
81blood coagulation, intrinsic pathway (GO:0007597)3.89219916
82complement activation, classical pathway (GO:0006958)3.87307492
83acetyl-CoA metabolic process (GO:0006084)3.86195696
84cytolysis (GO:0019835)3.84481388
85plasma lipoprotein particle assembly (GO:0034377)3.84322607
86low-density lipoprotein particle remodeling (GO:0034374)3.83956124
87aldehyde catabolic process (GO:0046185)3.81671155
88phospholipid homeostasis (GO:0055091)3.80150601
89glucuronate metabolic process (GO:0019585)3.79540221
90uronic acid metabolic process (GO:0006063)3.79540221
91complement activation (GO:0006956)3.77492428
92ketone body metabolic process (GO:1902224)3.77153540
93protein activation cascade (GO:0072376)3.76995486
94serine family amino acid biosynthetic process (GO:0009070)3.74201641
95very-low-density lipoprotein particle assembly (GO:0034379)3.69731824
96organic acid catabolic process (GO:0016054)3.69429132
97carboxylic acid catabolic process (GO:0046395)3.69429132
98positive regulation of lipid catabolic process (GO:0050996)3.67069103
99cholesterol homeostasis (GO:0042632)3.66746025
100intestinal cholesterol absorption (GO:0030299)3.66522557
101NAD biosynthetic process (GO:0009435)3.65493545
102positive regulation of lipoprotein lipase activity (GO:0051006)3.65129146
103positive regulation of triglyceride lipase activity (GO:0061365)3.65129146
104negative regulation of lipase activity (GO:0060192)3.64901308
105regulation of cholesterol homeostasis (GO:2000188)3.64054413
106sterol homeostasis (GO:0055092)3.60601923
107nicotinamide nucleotide biosynthetic process (GO:0019359)3.57540184
108pyridine nucleotide biosynthetic process (GO:0019363)3.57540184
109embryonic retina morphogenesis in camera-type eye (GO:0060059)3.53427027
110exogenous drug catabolic process (GO:0042738)3.51677784
111oxidative demethylation (GO:0070989)3.50240465
112plasma lipoprotein particle organization (GO:0071827)3.38964854
113negative regulation of digestive system process (GO:0060457)3.35803613
114positive regulation of hormone metabolic process (GO:0032352)3.25855889
115phenylpropanoid metabolic process (GO:0009698)3.22436595
116alkaloid metabolic process (GO:0009820)3.16485735
117protein-lipid complex subunit organization (GO:0071825)3.11614762
118behavioral response to nicotine (GO:0035095)3.10748994
119negative regulation of blood coagulation (GO:0030195)3.09507626
120negative regulation of hemostasis (GO:1900047)3.09507626
121negative regulation of fatty acid metabolic process (GO:0045922)3.07168472
122positive regulation of fatty acid biosynthetic process (GO:0045723)3.07141986
123glutamine family amino acid catabolic process (GO:0009065)3.06743129
124arginine catabolic process (GO:0006527)3.06135936
125sodium-independent organic anion transport (GO:0043252)3.05393787
126peptidyl-glutamic acid modification (GO:0018200)3.04481458
127acute-phase response (GO:0006953)3.02586258
128positive regulation of hormone biosynthetic process (GO:0046886)3.02458337
129protein-lipid complex assembly (GO:0065005)3.01770908
130neurofilament cytoskeleton organization (GO:0060052)2.98776104
131sterol transport (GO:0015918)2.96851269
132cholesterol transport (GO:0030301)2.96851269
133S-adenosylmethionine metabolic process (GO:0046500)2.95046349
134response to misfolded protein (GO:0051788)2.94116733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.08346781
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.01213778
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.89042607
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.38946117
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.37430920
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.70311703
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.19080351
8EZH2_22144423_ChIP-Seq_EOC_Human4.09774788
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05882912
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.58282848
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85072908
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.29913635
13DROSHA_22980978_ChIP-Seq_HELA_Human2.09517895
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4377286
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95138096
16* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93227613
17IGF1R_20145208_ChIP-Seq_DFB_Human1.90438381
18* CBX2_27304074_Chip-Seq_ESCs_Mouse1.86212705
19* REST_18959480_ChIP-ChIP_MESCs_Mouse1.79339959
20* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77121792
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75099812
22* EED_16625203_ChIP-ChIP_MESCs_Mouse1.73027177
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67579632
24HTT_18923047_ChIP-ChIP_STHdh_Human1.67546611
25GBX2_23144817_ChIP-Seq_PC3_Human1.64382918
26* EZH2_27304074_Chip-Seq_ESCs_Mouse1.63346003
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.62959817
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62742549
29* EZH2_27294783_Chip-Seq_ESCs_Mouse1.59779427
30* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59403661
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56809251
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56735172
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50389167
34* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50353508
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49772242
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46077588
37* RNF2_27304074_Chip-Seq_NSC_Mouse1.45471787
38* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45137002
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43143356
40HNF4A_19822575_ChIP-Seq_HepG2_Human1.38008906
41* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37815250
42* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32648366
43* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31760169
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.30413254
45CLOCK_20551151_ChIP-Seq_293T_Human1.29267084
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27814703
47* CTCF_27219007_Chip-Seq_Bcells_Human1.27505740
48* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27497469
49* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27497469
50ZNF274_21170338_ChIP-Seq_K562_Hela1.26551256
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19304929
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14964776
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14442076
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14442076
55* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12669788
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12240688
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10949070
58GATA1_22025678_ChIP-Seq_K562_Human1.10899144
59RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10857163
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10507532
61* RNF2_27304074_Chip-Seq_ESCs_Mouse1.08455439
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08172824
63* RING1B_27294783_Chip-Seq_ESCs_Mouse1.07796779
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06990999
65* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05888886
66TAF15_26573619_Chip-Seq_HEK293_Human1.05752580
67* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04961029
68* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03878049
69* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00116595
70VDR_22108803_ChIP-Seq_LS180_Human0.99884179
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95064059
72* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94092090
73* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93720043
74* TP53_20018659_ChIP-ChIP_R1E_Mouse0.93094969
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92932225
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92774131
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92674181
78* AR_19668381_ChIP-Seq_PC3_Human0.91227936
79* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90886018
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90520613
81* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88960399
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88916234
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88837615
84* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87980449
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86712967
86WDR5_24793694_ChIP-Seq_LNCAP_Human0.86624692
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86545605
88ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86515516
89SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86261311
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85379396
91KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84611775
92NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84468530
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83713853
94ERA_21632823_ChIP-Seq_H3396_Human0.81350204
95PHF8_20622854_ChIP-Seq_HELA_Human0.80515229
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.79624605
97GATA4_25053715_ChIP-Seq_YYC3_Human0.79387740
98RUNX2_22187159_ChIP-Seq_PCA_Human0.77743522
99STAT3_23295773_ChIP-Seq_U87_Human0.77299901
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.76788166
101P300_19829295_ChIP-Seq_ESCs_Human0.76361217
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76014874
103AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75670867
104NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75049772
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75049772
106MYC_19829295_ChIP-Seq_ESCs_Human0.74918655
107* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.74454992
108* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73643833
109* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.73603789
110OCT4_20526341_ChIP-Seq_ESCs_Human0.73555145
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71778017
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71316860
113SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70648614
114IRF8_22096565_ChIP-ChIP_GC-B_Human0.70009940
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.69053964
116RARG_19884340_ChIP-ChIP_MEFs_Mouse0.68171972
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.64626161
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.63959575
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.63626823
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.63506813
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62219849
122IRF1_19129219_ChIP-ChIP_H3396_Human0.61795568
123BCAT_22108803_ChIP-Seq_LS180_Human0.61344147
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.61113170
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.61043795
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.60467083
127* RARA_24833708_ChIP-Seq_LIVER_Mouse0.60460395
128STAT1_17558387_ChIP-Seq_HELA_Human0.60446003
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60311782
130FOXA1_25552417_ChIP-Seq_VCAP_Human0.58200121
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57907161
132RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57746652
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.57450522
134SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.57328787
135EZH2_27294783_Chip-Seq_NPCs_Mouse0.56568567
136ESR1_21235772_ChIP-Seq_MCF-7_Human0.55965993
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55550269
138SUZ12_27294783_Chip-Seq_NPCs_Mouse0.55510358
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.55482365
140* CBP_21632823_ChIP-Seq_H3396_Human0.55410478
141NFE2_27457419_Chip-Seq_LIVER_Mouse0.55329189
142BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.54261042
143EGR1_19032775_ChIP-ChIP_M12_Human0.53114427
144CDX2_20551321_ChIP-Seq_CACO-2_Human0.52833814
145SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.52178462
146ESET_19884257_ChIP-Seq_ESCs_Mouse0.51594293
147CEBPB_22108803_ChIP-Seq_LS180_Human0.50496457
148OCT4_21477851_ChIP-Seq_ESCs_Mouse0.50470144
149FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50171729
150CRX_20693478_ChIP-Seq_RETINA_Mouse0.49526849
151MYC_19915707_ChIP-ChIP_AK7_Human0.49375373
152RARB_24833708_ChIP-Seq_LIVER_Mouse0.49061051
153* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.48935349
154AR_20517297_ChIP-Seq_VCAP_Human0.48267790
155ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.47930522
156RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.46436580
157* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.45567583
158RUNX1_27457419_Chip-Seq_LIVER_Mouse0.44838778
159EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.44559322
160PPAR_26484153_Chip-Seq_NCI-H1993_Human0.44434963
161* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.43699301
162CDX2_22108803_ChIP-Seq_LS180_Human0.43014214
163FOXH1_21741376_ChIP-Seq_EPCs_Human0.42408388
164PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42207128
165FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.42140882
166PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.41672768
167RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.40165597
168P53_21459846_ChIP-Seq_SAOS-2_Human0.39789248
169* STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39632868
170ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.39431599
171MYC_27129775_Chip-Seq_CORNEA_Mouse0.38621049
172HNFA_21074721_ChIP-Seq_CACO-2_Human0.38397541
173FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.37626913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.54639456
2MP0005360_urolithiasis7.21791513
3MP0005085_abnormal_gallbladder_physiolo6.70541356
4MP0005365_abnormal_bile_salt6.53291553
5MP0008875_abnormal_xenobiotic_pharmacok4.94966003
6MP0003252_abnormal_bile_duct4.29577317
7MP0003806_abnormal_nucleotide_metabolis3.83027368
8MP0010329_abnormal_lipoprotein_level3.59946238
9MP0001666_abnormal_nutrient_absorption2.97401141
10MP0002138_abnormal_hepatobiliary_system2.82111474
11* MP0005083_abnormal_biliary_tract2.79108232
12MP0003195_calcinosis2.69857430
13MP0009840_abnormal_foam_cell2.63447938
14MP0005332_abnormal_amino_acid2.58540415
15MP0003868_abnormal_feces_composition2.38672348
16MP0003122_maternal_imprinting2.38546362
17MP0004019_abnormal_vitamin_homeostasis2.20461860
18MP0002118_abnormal_lipid_homeostasis2.11051294
19* MP0000609_abnormal_liver_physiology2.10284726
20MP0003191_abnormal_cellular_cholesterol1.99332217
21MP0010386_abnormal_urinary_bladder1.70074399
22MP0005319_abnormal_enzyme/_coenzyme1.68313851
23MP0006276_abnormal_autonomic_nervous1.61918558
24MP0003880_abnormal_central_pattern1.57316416
25MP0009697_abnormal_copulation1.57228958
26MP0002909_abnormal_adrenal_gland1.57037991
27MP0002089_abnormal_postnatal_growth/wei1.55196140
28MP0005451_abnormal_body_composition1.54820214
29MP0004133_heterotaxia1.51357668
30MP0001764_abnormal_homeostasis1.49361835
31MP0003879_abnormal_hair_cell1.49342135
32MP0003011_delayed_dark_adaptation1.47040277
33MP0000778_abnormal_nervous_system1.46369903
34MP0005584_abnormal_enzyme/coenzyme_acti1.35378773
35MP0002653_abnormal_ependyma_morphology1.27079761
36MP0004270_analgesia1.24576436
37MP0005647_abnormal_sex_gland1.19376659
38MP0002160_abnormal_reproductive_system1.19110842
39MP0004742_abnormal_vestibular_system1.18666049
40MP0002557_abnormal_social/conspecific_i1.18158507
41MP0005551_abnormal_eye_electrophysiolog1.14712168
42MP0003121_genomic_imprinting1.10206992
43MP0009643_abnormal_urine_homeostasis1.10087417
44MP0009764_decreased_sensitivity_to1.10043714
45* MP0000598_abnormal_liver_morphology1.09534319
46MP0005167_abnormal_blood-brain_barrier1.06959390
47MP0003656_abnormal_erythrocyte_physiolo1.05415224
48MP0001984_abnormal_olfaction1.03506867
49* MP0005220_abnormal_exocrine_pancreas1.03323431
50MP0000955_abnormal_spinal_cord1.02468968
51MP0003787_abnormal_imprinting1.02397211
52MP0001529_abnormal_vocalization1.02291902
53MP0002254_reproductive_system_inflammat1.01716390
54MP0003705_abnormal_hypodermis_morpholog1.01562974
55MP0003186_abnormal_redox_activity1.00687734
56MP0010368_abnormal_lymphatic_system0.97895370
57MP0009763_increased_sensitivity_to0.96825482
58MP0005499_abnormal_olfactory_system0.96619182
59MP0005394_taste/olfaction_phenotype0.96619182
60MP0005423_abnormal_somatic_nervous0.93967770
61MP0002735_abnormal_chemical_nociception0.91974613
62MP0003119_abnormal_digestive_system0.91304670
63MP0003635_abnormal_synaptic_transmissio0.89441712
64MP0002184_abnormal_innervation0.88316608
65MP0009745_abnormal_behavioral_response0.87550271
66* MP0005084_abnormal_gallbladder_morpholo0.87431399
67MP0002876_abnormal_thyroid_physiology0.86770742
68MP0000604_amyloidosis0.86643184
69MP0001485_abnormal_pinna_reflex0.84964287
70MP0002064_seizures0.84576288
71MP0005636_abnormal_mineral_homeostasis0.84261316
72MP0001486_abnormal_startle_reflex0.84124045
73MP0002272_abnormal_nervous_system0.83087573
74* MP0009642_abnormal_blood_homeostasis0.81779697
75MP0002882_abnormal_neuron_morphology0.81572234
76MP0003123_paternal_imprinting0.81382397
77MP0009046_muscle_twitch0.81249038
78MP0002572_abnormal_emotion/affect_behav0.80809495
79MP0008469_abnormal_protein_level0.80414667
80MP0002752_abnormal_somatic_nervous0.80147860
81MP0002063_abnormal_learning/memory/cond0.79897279
82MP0003567_abnormal_fetal_cardiomyocyte0.78340868
83* MP0002078_abnormal_glucose_homeostasis0.78147376
84MP0009765_abnormal_xenobiotic_induced0.77379623
85MP0003890_abnormal_embryonic-extraembry0.77056051
86MP0001440_abnormal_grooming_behavior0.73971806
87MP0005187_abnormal_penis_morphology0.73787712
88MP0005408_hypopigmentation0.73760453
89MP0005334_abnormal_fat_pad0.73707153
90MP0003183_abnormal_peptide_metabolism0.72722089
91MP0003632_abnormal_nervous_system0.72585898
92MP0005377_hearing/vestibular/ear_phenot0.72411431
93MP0003878_abnormal_ear_physiology0.72411431
94MP0002734_abnormal_mechanical_nocicepti0.71740986
95MP0006292_abnormal_olfactory_placode0.71340302
96* MP0002928_abnormal_bile_duct0.70821592
97MP0000579_abnormal_nail_morphology0.70476109
98MP0002067_abnormal_sensory_capabilities0.70127538
99MP0005376_homeostasis/metabolism_phenot0.70113564
100MP0002069_abnormal_eating/drinking_beha0.69873726
101MP0009379_abnormal_foot_pigmentation0.69867348
102MP0001188_hyperpigmentation0.69084052
103MP0009384_cardiac_valve_regurgitation0.68851810
104MP0003631_nervous_system_phenotype0.67459970
105MP0005448_abnormal_energy_balance0.66155890
106MP0004381_abnormal_hair_follicle0.66061820
107MP0005645_abnormal_hypothalamus_physiol0.65244563
108MP0002971_abnormal_brown_adipose0.64936676
109MP0002229_neurodegeneration0.64314673
110MP0005535_abnormal_body_temperature0.64066021
111MP0005670_abnormal_white_adipose0.63593508
112MP0004811_abnormal_neuron_physiology0.63555587
113MP0005195_abnormal_posterior_eye0.63522557
114MP0004142_abnormal_muscle_tone0.63057400
115MP0002152_abnormal_brain_morphology0.62693851
116MP0003633_abnormal_nervous_system0.62058288
117MP0006036_abnormal_mitochondrial_physio0.61343190
118MP0009053_abnormal_anal_canal0.58168161
119MP0000639_abnormal_adrenal_gland0.57052574
120MP0004130_abnormal_muscle_cell0.56782204
121MP0005395_other_phenotype0.52676996
122MP0003690_abnormal_glial_cell0.52144851
123MP0000566_synostosis0.51783505
124MP0001661_extended_life_span0.50400058
125MP0001756_abnormal_urination0.50222889
126MP0004782_abnormal_surfactant_physiolog0.50055419
127MP0005266_abnormal_metabolism0.49363376
128MP0006035_abnormal_mitochondrial_morpho0.47977968
129MP0003724_increased_susceptibility_to0.47220591
130MP0003638_abnormal_response/metabolism_0.47041069
131MP0005248_abnormal_Harderian_gland0.46355398
132MP0009672_abnormal_birth_weight0.45412806
133MP0003329_amyloid_beta_deposits0.45166499
134MP0002168_other_aberrant_phenotype0.42632205
135* MP0003953_abnormal_hormone_level0.42478190
136MP0003718_maternal_effect0.41935158
137MP0002822_catalepsy0.41573304
138MP0002796_impaired_skin_barrier0.40985066
139MP0003959_abnormal_lean_body0.40346779
140MP0008874_decreased_physiological_sensi0.39530036
141MP0004883_abnormal_blood_vessel0.39367874
142MP0002136_abnormal_kidney_physiology0.38421111
143MP0005464_abnormal_platelet_physiology0.37456869
144MP0000427_abnormal_hair_cycle0.36043299
145MP0008872_abnormal_physiological_respon0.34882599
146* MP0001944_abnormal_pancreas_morphology0.34095501
147MP0003436_decreased_susceptibility_to0.33679243
148MP0005166_decreased_susceptibility_to0.32498244
149MP0008873_increased_physiological_sensi0.31333814
150MP0002060_abnormal_skin_morphology0.30543406
151MP0001881_abnormal_mammary_gland0.29852102
152MP0001324_abnormal_eye_pigmentation0.28087157
153MP0004264_abnormal_extraembryonic_tissu0.27721053
154MP0000230_abnormal_systemic_arterial0.27578284
155MP0001853_heart_inflammation0.26416299
156MP0001243_abnormal_dermal_layer0.26095352
157MP0003075_altered_response_to0.25945231
158MP0002970_abnormal_white_adipose0.25749795
159MP0005164_abnormal_response_to0.25733743
160MP0002090_abnormal_vision0.25685699

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.60879001
2Deep venous thrombosis (HP:0002625)7.42872981
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.26496940
4Prolonged partial thromboplastin time (HP:0003645)6.80049287
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.60237730
6Hypobetalipoproteinemia (HP:0003563)6.52612888
7Xanthomatosis (HP:0000991)6.13924744
8Complement deficiency (HP:0004431)5.81635571
9Hyperlipoproteinemia (HP:0010980)5.34971179
10Joint hemorrhage (HP:0005261)4.99741682
11Hypolipoproteinemia (HP:0010981)4.77796909
12Hyperglycinemia (HP:0002154)4.62603582
13Epidermoid cyst (HP:0200040)4.56708139
14Abnormality of the common coagulation pathway (HP:0010990)4.53829602
15Fat malabsorption (HP:0002630)4.49235466
16Hyperammonemia (HP:0001987)4.43338498
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.31764591
18Ketosis (HP:0001946)4.25688414
19Abnormality of methionine metabolism (HP:0010901)4.21069739
20Abnormality of complement system (HP:0005339)4.18359949
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.16161180
22Hypoalphalipoproteinemia (HP:0003233)4.14089407
23Conjugated hyperbilirubinemia (HP:0002908)4.10322377
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.06895827
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.05503769
26Abnormality of pyrimidine metabolism (HP:0004353)3.90775151
27Abnormality of glycine metabolism (HP:0010895)3.89910631
28Abnormality of serine family amino acid metabolism (HP:0010894)3.89910631
29Hyperglycinuria (HP:0003108)3.87630846
30Hypoglycemic coma (HP:0001325)3.84521709
31Abnormality of the intrinsic pathway (HP:0010989)3.76454074
32Hypercholesterolemia (HP:0003124)3.46552163
33Steatorrhea (HP:0002570)3.44394834
34Hyperbilirubinemia (HP:0002904)3.24941392
35Spontaneous abortion (HP:0005268)3.14920447
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.13717149
37Abnormality of serum amino acid levels (HP:0003112)3.13059899
38Hypochromic microcytic anemia (HP:0004840)3.09822253
39Myocardial infarction (HP:0001658)3.08448976
40Abnormality of nucleobase metabolism (HP:0010932)3.07375321
41Abnormality of fatty-acid metabolism (HP:0004359)3.04227494
42Hepatocellular carcinoma (HP:0001402)2.96784790
43Ketoacidosis (HP:0001993)2.96223558
44Myokymia (HP:0002411)2.91480564
45Delayed CNS myelination (HP:0002188)2.84128713
46Systemic lupus erythematosus (HP:0002725)2.83112806
47Hypoglycemic seizures (HP:0002173)2.78732172
48Skin nodule (HP:0200036)2.76977879
49Gout (HP:0001997)2.75107093
50Osteomalacia (HP:0002749)2.68143607
51Recurrent gram-negative bacterial infections (HP:0005420)2.66557402
52Abnormality of purine metabolism (HP:0004352)2.65675406
53Metabolic acidosis (HP:0001942)2.65328578
54Progressive cerebellar ataxia (HP:0002073)2.64665904
55Acanthocytosis (HP:0001927)2.60718139
56Enlarged kidneys (HP:0000105)2.57727645
57Mitral stenosis (HP:0001718)2.57664279
58Genetic anticipation (HP:0003743)2.56230800
59Glomerulonephritis (HP:0000099)2.52765719
60Vascular calcification (HP:0004934)2.52505790
61Lethargy (HP:0001254)2.51454619
62Facial shape deformation (HP:0011334)2.48717399
63Potter facies (HP:0002009)2.48717399
64Neonatal onset (HP:0003623)2.47740422
65Esophageal varix (HP:0002040)2.42470932
66Cerebral edema (HP:0002181)2.39805945
67Abnormal urine phosphate concentration (HP:0012599)2.39224740
68Dicarboxylic aciduria (HP:0003215)2.37792763
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37792763
70Spastic diplegia (HP:0001264)2.36091012
71Abnormal gallbladder morphology (HP:0012437)2.34059675
72Cortical dysplasia (HP:0002539)2.32752739
73Hyperphosphaturia (HP:0003109)2.29928410
74Cardiovascular calcification (HP:0011915)2.26831775
75Neoplasm of the liver (HP:0002896)2.26493505
76Late onset (HP:0003584)2.26234486
77Cholelithiasis (HP:0001081)2.26106223
78Irritability (HP:0000737)2.23756823
79Reticulocytosis (HP:0001923)2.23479920
80Gingival bleeding (HP:0000225)2.22290584
81Increased serum pyruvate (HP:0003542)2.22203517
82Abnormal gallbladder physiology (HP:0012438)2.22012425
83Cholecystitis (HP:0001082)2.22012425
84Hyperinsulinemic hypoglycemia (HP:0000825)2.21548609
85Menorrhagia (HP:0000132)2.19313140
86Amyloidosis (HP:0011034)2.18719599
87Pancreatitis (HP:0001733)2.14953899
88Malnutrition (HP:0004395)2.12614227
89Hypothermia (HP:0002045)2.12260481
90Thrombophlebitis (HP:0004418)2.11975856
91Brushfield spots (HP:0001088)2.10135029
92Proximal tubulopathy (HP:0000114)2.08056168
93Opisthotonus (HP:0002179)2.04833128
94Sensorimotor neuropathy (HP:0007141)2.04049217
95Abnormality of glycolysis (HP:0004366)2.02595764
96Bile duct proliferation (HP:0001408)2.01553231
97Abnormal biliary tract physiology (HP:0012439)2.01553231
98Abnormality of urine glucose concentration (HP:0011016)1.97777945
99Glycosuria (HP:0003076)1.97777945
100Hemorrhage of the eye (HP:0011885)1.96781912
101Hypophosphatemic rickets (HP:0004912)1.95904828
102Vomiting (HP:0002013)1.95782038
103Hyperglycemia (HP:0003074)1.95409157
104Rickets (HP:0002748)1.94001052
105Renal cortical cysts (HP:0000803)1.92814705
106Retinal atrophy (HP:0001105)1.91823885
107Drooling (HP:0002307)1.91807269
108Anosmia (HP:0000458)1.91517163
109Poikilocytosis (HP:0004447)1.91229062
110Abnormality of the intervertebral disk (HP:0005108)1.91021846
111Abnormality of the gallbladder (HP:0005264)1.90985439
112Symptomatic seizures (HP:0011145)1.90842470
113Agitation (HP:0000713)1.89457462
114Limb dystonia (HP:0002451)1.89065266
115Spastic tetraplegia (HP:0002510)1.88407297
116Cerebral palsy (HP:0100021)1.88319854
117Hepatoblastoma (HP:0002884)1.88172134
118Generalized aminoaciduria (HP:0002909)1.86869159
119Back pain (HP:0003418)1.86207698
120Status epilepticus (HP:0002133)1.86099303
121Hyperventilation (HP:0002883)1.82360844
122Abnormal enzyme/coenzyme activity (HP:0012379)1.82302999
123Fair hair (HP:0002286)1.80072498
124Focal segmental glomerulosclerosis (HP:0000097)1.79986889
125Elevated hepatic transaminases (HP:0002910)1.79652894
126Hydroxyprolinuria (HP:0003080)1.78523967
127Abnormality of proline metabolism (HP:0010907)1.78523967
128Abnormality of iron homeostasis (HP:0011031)1.78358456
129Glomerulosclerosis (HP:0000096)1.78063186
130Arthropathy (HP:0003040)1.77398111
131Abnormal cartilage morphology (HP:0002763)1.75385182
132Type I diabetes mellitus (HP:0100651)1.74948577
133Abnormal pancreas size (HP:0012094)1.72307190
134Chorioretinal atrophy (HP:0000533)1.69938200
135Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69932961
136Abnormality of alanine metabolism (HP:0010916)1.69932961
137Hyperalaninemia (HP:0003348)1.69932961
138Decreased central vision (HP:0007663)1.69691097
139Excessive salivation (HP:0003781)1.66815669
140Abnormality of the lower motor neuron (HP:0002366)1.66173517
141Focal seizures (HP:0007359)1.64108973

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.01190542
2SIK14.65849450
3FGFR44.57487808
4ERN13.98764232
5ERBB43.94871078
6INSRR3.64823727
7MARK13.62494017
8TAOK33.52304996
9MAP3K43.05761503
10MAP2K72.84932678
11BCR2.74179901
12CDK192.52880079
13MAP2K42.46620248
14NTRK32.42244473
15LATS12.39030465
16MST1R2.27667449
17PIK3CG1.95945999
18MAPK111.95759140
19DAPK21.93038753
20DYRK31.91351323
21FGFR21.88834220
22SIK21.88611106
23ADRBK21.65246167
24WNK41.61495539
25MINK11.56124445
26ERBB21.54931936
27PKN21.42343993
28PNCK1.34936898
29MAPK131.33935555
30ABL21.33864421
31OXSR11.28065141
32SRPK11.27168035
33PTK61.25079086
34FRK1.22134928
35STK38L1.20257823
36MAPK41.19251063
37TYK21.18308004
38PRKAA21.17969723
39NEK91.16429155
40JAK21.14416931
41FLT31.11161918
42TNIK1.09048953
43MAP3K71.08537992
44CAMKK21.03974928
45PAK31.00630622
46MAP4K21.00393530
47TYRO30.99956585
48DYRK1B0.99089457
49MAP3K140.97106606
50PKN10.96645002
51PRKCZ0.96129027
52NTRK10.92572241
53CAMK1D0.91030382
54DDR20.88934043
55CSNK1E0.88411353
56JAK10.87781021
57MAP3K60.86978073
58CDK50.86975179
59KDR0.86481769
60GRK10.84714317
61IRAK30.83891624
62MAPK150.81716525
63SGK20.80679818
64DYRK1A0.80199196
65MAPK120.80118104
66BMPR1B0.77583403
67TRIM280.75099809
68CAMK2G0.74936186
69PRKACG0.74482302
70MAP2K60.74015932
71EPHB20.73045482
72PIK3CA0.71713844
73MARK20.71344723
74GSK3A0.71203045
75PINK10.70316565
76PRKAA10.69175022
77TBK10.68642719
78SGK30.68329702
79EPHA30.67299832
80SGK2230.67198112
81SGK4940.67198112
82MAP3K110.66536576
83FGFR30.66365229
84CAMKK10.65547873
85PRKACA0.65286531
86TRIB30.62661817
87TAOK20.62048512
88STK160.60650307
89CDK180.60632854
90LATS20.60266261
91CDK150.59970682
92RPS6KA20.59625284
93CDK140.58668308
94PRKCE0.58453580
95CSNK1A10.57224679
96CSNK1G10.56627367
97STK240.55756716
98CDK11A0.54609661
99CAMK1G0.54214455
100MAP3K100.53494223
101CDK120.52680516
102PRKG10.50461576
103CAMK40.50259682
104MET0.49688021
105CSK0.49555640
106PHKG10.47741653
107PHKG20.47741653
108TIE10.47648426
109CAMK2A0.47421815
110IGF1R0.47369906
111TGFBR20.46132039
112IRAK20.45381112
113GRK60.45361652
114CASK0.45073990
115MAP3K10.44113725
116PRKCG0.43781908
117ICK0.43609868
118CSNK1A1L0.43531308
119RPS6KA30.42986541
120RIPK10.42957894
121MAPK70.42579757
122WNK30.42083726
123STK390.41784359
124EPHB10.40902784
125SGK10.39575669
126GSK3B0.39535210
127MAP3K50.39019382
128RET0.38861434
129MAP3K30.38707111
130ADRBK10.38574053
131CDK60.38273273
132PRKCQ0.37830338
133PTK20.37810287
134CAMK10.37649554
135PRKCB0.37592825
136CHUK0.36267677
137CSF1R0.35752989
138PASK0.35118393
139MAPK80.34788621
140MAP2K10.34562805
141MAPK90.33874793
142CSNK1D0.33526448
143CDK40.33053591
144DYRK20.31627270
145CSNK1G30.31175379
146CSNK1G20.30615853
147PRKCA0.28460165
148NTRK20.28094266
149EPHA40.28052320
150PRKACB0.28040209
151ABL10.27955661
152MTOR0.27881401
153FGFR10.27847515
154STK110.26896985
155EGFR0.26417045

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.68659827
2Nitrogen metabolism_Homo sapiens_hsa009103.50790696
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29382332
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.29158272
5Arginine biosynthesis_Homo sapiens_hsa002202.98117760
6Complement and coagulation cascades_Homo sapiens_hsa046102.83634707
7Tryptophan metabolism_Homo sapiens_hsa003802.80437499
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.72980697
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56034731
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49832473
11Fatty acid degradation_Homo sapiens_hsa000712.48164519
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36334602
13Butanoate metabolism_Homo sapiens_hsa006502.20947933
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19560494
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14015929
16Peroxisome_Homo sapiens_hsa041462.12733164
17Steroid hormone biosynthesis_Homo sapiens_hsa001402.02305528
18Chemical carcinogenesis_Homo sapiens_hsa052041.92610696
19PPAR signaling pathway_Homo sapiens_hsa033201.89500496
20Histidine metabolism_Homo sapiens_hsa003401.88126296
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86445927
22Propanoate metabolism_Homo sapiens_hsa006401.85988847
23Fatty acid metabolism_Homo sapiens_hsa012121.81635163
24Staphylococcus aureus infection_Homo sapiens_hsa051501.80273171
25Retinol metabolism_Homo sapiens_hsa008301.78805525
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.72917131
27beta-Alanine metabolism_Homo sapiens_hsa004101.71916518
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71615887
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68682274
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64310699
31Caffeine metabolism_Homo sapiens_hsa002321.61585444
32Phenylalanine metabolism_Homo sapiens_hsa003601.55446243
33Selenocompound metabolism_Homo sapiens_hsa004501.51982397
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49612408
35Bile secretion_Homo sapiens_hsa049761.46121173
36Tyrosine metabolism_Homo sapiens_hsa003501.45501539
37* Maturity onset diabetes of the young_Homo sapiens_hsa049501.38653097
38Fatty acid elongation_Homo sapiens_hsa000621.38620338
39Steroid biosynthesis_Homo sapiens_hsa001001.37511224
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36704827
41Fat digestion and absorption_Homo sapiens_hsa049751.34853064
42Sulfur metabolism_Homo sapiens_hsa009201.29469225
43Starch and sucrose metabolism_Homo sapiens_hsa005001.29158398
44Pyruvate metabolism_Homo sapiens_hsa006201.28640756
45ABC transporters_Homo sapiens_hsa020101.22365378
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.21199079
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10963335
48Folate biosynthesis_Homo sapiens_hsa007901.10470877
49Vitamin B6 metabolism_Homo sapiens_hsa007501.05743219
50Biosynthesis of amino acids_Homo sapiens_hsa012301.05064643
51Nicotine addiction_Homo sapiens_hsa050331.04798265
52Carbon metabolism_Homo sapiens_hsa012000.98919373
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.93071535
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92831552
55Arginine and proline metabolism_Homo sapiens_hsa003300.90953806
56Lysine degradation_Homo sapiens_hsa003100.89434332
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89424500
58Vitamin digestion and absorption_Homo sapiens_hsa049770.88969738
59Sulfur relay system_Homo sapiens_hsa041220.86937042
60GABAergic synapse_Homo sapiens_hsa047270.84411514
61One carbon pool by folate_Homo sapiens_hsa006700.77732797
62Glycerolipid metabolism_Homo sapiens_hsa005610.72227544
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67794172
64Fatty acid biosynthesis_Homo sapiens_hsa000610.65665536
65Renin-angiotensin system_Homo sapiens_hsa046140.59209511
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57671506
67Glutathione metabolism_Homo sapiens_hsa004800.55444212
68Serotonergic synapse_Homo sapiens_hsa047260.50379006
69Phototransduction_Homo sapiens_hsa047440.49091499
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48656901
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48304174
72Metabolic pathways_Homo sapiens_hsa011000.44290269
73Type II diabetes mellitus_Homo sapiens_hsa049300.44195804
74Prion diseases_Homo sapiens_hsa050200.44181525
75Pentose phosphate pathway_Homo sapiens_hsa000300.42996577
76Cocaine addiction_Homo sapiens_hsa050300.42751283
77Glutamatergic synapse_Homo sapiens_hsa047240.41308058
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37730160
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35950932
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34149017
81Morphine addiction_Homo sapiens_hsa050320.33368632
82Oxidative phosphorylation_Homo sapiens_hsa001900.32427915
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30889497
84Axon guidance_Homo sapiens_hsa043600.29620829
85Cardiac muscle contraction_Homo sapiens_hsa042600.28941247
86Taste transduction_Homo sapiens_hsa047420.27378359
87Dopaminergic synapse_Homo sapiens_hsa047280.26944209
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25475670
89Sphingolipid metabolism_Homo sapiens_hsa006000.23285651
90Parkinsons disease_Homo sapiens_hsa050120.23128618
91Linoleic acid metabolism_Homo sapiens_hsa005910.22906990
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22603421
93Insulin resistance_Homo sapiens_hsa049310.21685861
94Galactose metabolism_Homo sapiens_hsa000520.20014437
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.18831641
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17977434
97Pancreatic secretion_Homo sapiens_hsa049720.17510368
98Glucagon signaling pathway_Homo sapiens_hsa049220.15127563
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.12608835
100Synaptic vesicle cycle_Homo sapiens_hsa047210.12185477
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.11460573
102Fructose and mannose metabolism_Homo sapiens_hsa000510.11343143
103Circadian entrainment_Homo sapiens_hsa047130.11172300
104Insulin secretion_Homo sapiens_hsa049110.11154225
105Ovarian steroidogenesis_Homo sapiens_hsa049130.02178821
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.00860325
107AMPK signaling pathway_Homo sapiens_hsa041520.00598233
108Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2393208
109Amoebiasis_Homo sapiens_hsa05146-0.2392957
110Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2391485
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2390886
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2145799
113Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2143884
114Ether lipid metabolism_Homo sapiens_hsa00565-0.2049981
115Bladder cancer_Homo sapiens_hsa05219-0.1978816
116Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1755187
117Circadian rhythm_Homo sapiens_hsa04710-0.1702156
118Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1553855
119Protein digestion and absorption_Homo sapiens_hsa04974-0.1540563
120Hepatitis C_Homo sapiens_hsa05160-0.1461568
121African trypanosomiasis_Homo sapiens_hsa05143-0.1269333
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1062673
123Regulation of autophagy_Homo sapiens_hsa04140-0.0932784
124Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0807340
125Insulin signaling pathway_Homo sapiens_hsa04910-0.0642115
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0358454

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