ONECUT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.39955711
2L-phenylalanine catabolic process (GO:0006559)7.39955711
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.85252178
4L-phenylalanine metabolic process (GO:0006558)6.85252178
5aromatic amino acid family catabolic process (GO:0009074)6.38427467
6tryptophan catabolic process (GO:0006569)5.56058137
7indole-containing compound catabolic process (GO:0042436)5.56058137
8indolalkylamine catabolic process (GO:0046218)5.56058137
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.56021366
10bile acid biosynthetic process (GO:0006699)5.42974776
11behavioral response to nicotine (GO:0035095)5.34490940
12glyoxylate metabolic process (GO:0046487)5.28908857
13auditory behavior (GO:0031223)5.25918560
14kynurenine metabolic process (GO:0070189)5.24623827
15tryptophan metabolic process (GO:0006568)5.18153450
16urea cycle (GO:0000050)4.99362103
17urea metabolic process (GO:0019627)4.99362103
18cell migration in hindbrain (GO:0021535)4.98827014
19positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.83642054
20regulation of fibrinolysis (GO:0051917)4.83450916
21high-density lipoprotein particle remodeling (GO:0034375)4.81298890
22negative regulation of fibrinolysis (GO:0051918)4.74546619
23alpha-linolenic acid metabolic process (GO:0036109)4.73140275
24cysteine metabolic process (GO:0006534)4.72844935
25bile acid metabolic process (GO:0008206)4.71193268
26cellular ketone body metabolic process (GO:0046950)4.70210200
27nitrogen cycle metabolic process (GO:0071941)4.63660050
28complement activation, alternative pathway (GO:0006957)4.61817756
29neurofilament cytoskeleton organization (GO:0060052)4.60399558
30neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.55321994
31aromatic amino acid family metabolic process (GO:0009072)4.54102355
32peristalsis (GO:0030432)4.51654851
33protein carboxylation (GO:0018214)4.46648201
34peptidyl-glutamic acid carboxylation (GO:0017187)4.46648201
35regulation of protein activation cascade (GO:2000257)4.44963773
36tyrosine metabolic process (GO:0006570)4.40066030
37coenzyme catabolic process (GO:0009109)4.39850676
38regulation of cholesterol esterification (GO:0010872)4.39533090
39reverse cholesterol transport (GO:0043691)4.33150566
40fatty acid elongation (GO:0030497)4.30542658
41sulfur amino acid catabolic process (GO:0000098)4.24644438
42regulation of triglyceride catabolic process (GO:0010896)4.20546054
43plasma lipoprotein particle remodeling (GO:0034369)4.18593055
44protein-lipid complex remodeling (GO:0034368)4.18593055
45macromolecular complex remodeling (GO:0034367)4.18593055
46substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.18152600
47substrate-independent telencephalic tangential migration (GO:0021826)4.18152600
48presynaptic membrane assembly (GO:0097105)4.17517896
49cellular glucuronidation (GO:0052695)4.16870242
50neuron recognition (GO:0008038)4.12594807
51acylglycerol homeostasis (GO:0055090)4.12487797
52triglyceride homeostasis (GO:0070328)4.12487797
53cholesterol efflux (GO:0033344)4.11261080
54regulation of synapse structural plasticity (GO:0051823)4.10710562
55bile acid and bile salt transport (GO:0015721)4.09431886
56regulation of complement activation (GO:0030449)4.08546075
57ketone body metabolic process (GO:1902224)4.07711336
58protein localization to synapse (GO:0035418)4.06740018
59amine catabolic process (GO:0009310)4.06221120
60cellular biogenic amine catabolic process (GO:0042402)4.06221120
61phospholipid efflux (GO:0033700)4.02849374
62serine family amino acid catabolic process (GO:0009071)4.01933212
63homocysteine metabolic process (GO:0050667)4.01297057
64fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.99604748
65postsynaptic membrane organization (GO:0001941)3.98963581
66indolalkylamine metabolic process (GO:0006586)3.97781595
67mechanosensory behavior (GO:0007638)3.97204193
68presynaptic membrane organization (GO:0097090)3.97034212
69pyrimidine nucleobase catabolic process (GO:0006208)3.96693765
70protein localization to cilium (GO:0061512)3.96492154
71very-low-density lipoprotein particle assembly (GO:0034379)3.92631681
72uronic acid metabolic process (GO:0006063)3.92247631
73glucuronate metabolic process (GO:0019585)3.92247631
74alpha-amino acid catabolic process (GO:1901606)3.91962776
75aldehyde catabolic process (GO:0046185)3.91339872
76negative regulation of sterol transport (GO:0032372)3.91023390
77negative regulation of cholesterol transport (GO:0032375)3.91023390
78plasma lipoprotein particle clearance (GO:0034381)3.90262469
79axonal fasciculation (GO:0007413)3.88879763
80negative regulation of cytosolic calcium ion concentration (GO:0051481)3.85132475
81drug catabolic process (GO:0042737)3.82402454
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.80769477
83regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.80605394
84synapse assembly (GO:0007416)3.79712637
85fibrinolysis (GO:0042730)3.79080777
86regulation of bile acid biosynthetic process (GO:0070857)3.78314665
87dendrite morphogenesis (GO:0048813)3.77264182
88opsonization (GO:0008228)3.76277306
89neurotransmitter-gated ion channel clustering (GO:0072578)3.75627746
90response to auditory stimulus (GO:0010996)3.74841775
91cholesterol biosynthetic process (GO:0006695)3.73780345
92imidazole-containing compound metabolic process (GO:0052803)3.71700649
93neuromuscular synaptic transmission (GO:0007274)3.71340605
94synaptic transmission, cholinergic (GO:0007271)3.71030731
95dendritic spine morphogenesis (GO:0060997)3.69934532
96glutamate metabolic process (GO:0006536)3.69092671
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.68639051
98arginine metabolic process (GO:0006525)3.68189060
99plasma lipoprotein particle assembly (GO:0034377)3.67710761
100very long-chain fatty acid metabolic process (GO:0000038)3.67266292
101neuron cell-cell adhesion (GO:0007158)3.65867780
102cofactor catabolic process (GO:0051187)3.65290491
103acetyl-CoA metabolic process (GO:0006084)3.61220802
104amino-acid betaine metabolic process (GO:0006577)3.59992130
105negative regulation of lipase activity (GO:0060192)3.58949938
106benzene-containing compound metabolic process (GO:0042537)3.58070399
107low-density lipoprotein particle remodeling (GO:0034374)3.57757493
108intestinal cholesterol absorption (GO:0030299)3.56755742
109cellular amino acid catabolic process (GO:0009063)3.56663746
110blood coagulation, intrinsic pathway (GO:0007597)3.55951725
111positive regulation of growth hormone secretion (GO:0060124)3.55769198
112behavioral response to ethanol (GO:0048149)3.55244949
113positive regulation of triglyceride lipase activity (GO:0061365)3.51664545
114positive regulation of lipoprotein lipase activity (GO:0051006)3.51664545
115cholesterol homeostasis (GO:0042632)3.45919598
116retinal ganglion cell axon guidance (GO:0031290)3.43283187
117flavonoid metabolic process (GO:0009812)3.42542966
118nucleobase catabolic process (GO:0046113)3.40675163
119cellular modified amino acid catabolic process (GO:0042219)3.39725800
120sterol homeostasis (GO:0055092)3.39512178
121response to nitrosative stress (GO:0051409)3.37340027
122mitochondrion transport along microtubule (GO:0047497)3.36254859
123establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.36254859
124lysine catabolic process (GO:0006554)3.32379795
125lysine metabolic process (GO:0006553)3.32379795
126protein-lipid complex assembly (GO:0065005)3.31408055
127regulation of dopamine secretion (GO:0014059)3.31159111
128central nervous system projection neuron axonogenesis (GO:0021952)3.31020649
129striatum development (GO:0021756)3.30348496
130spinal cord development (GO:0021510)3.28141737
131protein activation cascade (GO:0072376)3.28059974
132short-chain fatty acid metabolic process (GO:0046459)3.27528239
133exogenous drug catabolic process (GO:0042738)3.26624042
134adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.25756916
135establishment of mitochondrion localization (GO:0051654)3.25634160
136ethanol oxidation (GO:0006069)3.25539128
137sterol biosynthetic process (GO:0016126)3.22813879
138drug metabolic process (GO:0017144)3.22478243
139serine family amino acid metabolic process (GO:0009069)3.22035750
140response to histamine (GO:0034776)3.19803540
141plasma lipoprotein particle organization (GO:0071827)3.19612146
142complement activation, classical pathway (GO:0006958)3.19218598
143negative regulation of catecholamine secretion (GO:0033604)3.18379919
144axon extension (GO:0048675)3.18302513
145neuronal ion channel clustering (GO:0045161)3.17475765
146regulation of respiratory system process (GO:0044065)3.16907283
147regulation of short-term neuronal synaptic plasticity (GO:0048172)3.10282514
148positive regulation of neurotransmitter transport (GO:0051590)3.07857502
149hindbrain development (GO:0030902)3.07414609
150regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.06360842
151regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.06360842
152regulation of growth hormone secretion (GO:0060123)3.04533937
153transmission of nerve impulse (GO:0019226)3.03680841
154short-term memory (GO:0007614)3.01161058
155regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.92874509
156behavioral response to cocaine (GO:0048148)2.91469003
157cell differentiation in hindbrain (GO:0021533)2.86444360
158synapse organization (GO:0050808)2.84145247
159negative regulation of translation, ncRNA-mediated (GO:0040033)2.82663770
160regulation of translation, ncRNA-mediated (GO:0045974)2.82663770
161negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.82663770
162adult walking behavior (GO:0007628)2.81671272
163neuron migration (GO:0001764)2.80373229
164central nervous system neuron axonogenesis (GO:0021955)2.78631343
165response to inactivity (GO:0014854)2.77959283
166positive regulation of synapse assembly (GO:0051965)2.74628579
167regulation of respiratory gaseous exchange (GO:0043576)2.74075072
168layer formation in cerebral cortex (GO:0021819)2.73281822
169dopamine receptor signaling pathway (GO:0007212)2.72550727
170vocalization behavior (GO:0071625)2.72353438
171ganglion development (GO:0061548)2.69833053
172positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.65128284
173positive regulation of dendritic spine morphogenesis (GO:0061003)2.65064720
174cerebellar Purkinje cell differentiation (GO:0021702)2.64418260
175neuron maturation (GO:0042551)2.62781093
176body morphogenesis (GO:0010171)2.60607415
177negative regulation of neurotransmitter secretion (GO:0046929)2.60266014
178sympathetic nervous system development (GO:0048485)2.57880487
179regulation of NFAT protein import into nucleus (GO:0051532)2.56307209
180motor neuron axon guidance (GO:0008045)2.55072937
181skeletal muscle organ development (GO:0060538)2.54614417
182phasic smooth muscle contraction (GO:0014821)2.54148623
183cerebellar granule cell differentiation (GO:0021707)2.52474266
184spinal cord association neuron differentiation (GO:0021527)2.52291677
185synaptic transmission, glutamatergic (GO:0035249)2.52196388
186response to nicotine (GO:0035094)2.51778514
187regulation of synaptic vesicle exocytosis (GO:2000300)2.49376069
188prepulse inhibition (GO:0060134)2.49199416
189cranial nerve morphogenesis (GO:0021602)2.48570320
190membrane depolarization during action potential (GO:0086010)2.48307074
191synaptic transmission, dopaminergic (GO:0001963)2.48287128
192neuron projection extension (GO:1990138)2.47593005
193regulation of axon guidance (GO:1902667)2.47379057
194dendrite development (GO:0016358)2.47162158
195neuronal action potential (GO:0019228)2.46596909
196regulation of synaptic transmission, GABAergic (GO:0032228)2.46221770
197* endocrine pancreas development (GO:0031018)2.45943438

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.71367971
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.41816988
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.90914951
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.37266577
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.37109820
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.53017033
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.11475352
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.88216957
9GBX2_23144817_ChIP-Seq_PC3_Human2.53599604
10TAF15_26573619_Chip-Seq_HEK293_Human2.47941279
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.35971809
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20043672
13* RNF2_27304074_Chip-Seq_ESCs_Mouse2.02300556
14* REST_18959480_ChIP-ChIP_MESCs_Mouse2.00673769
15RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95965544
16RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.83970518
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81799637
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78653003
19HTT_18923047_ChIP-ChIP_STHdh_Human1.72208856
20EZH2_22144423_ChIP-Seq_EOC_Human1.71172571
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59094796
22* TP53_20018659_ChIP-ChIP_R1E_Mouse1.57522684
23* RING1B_27294783_Chip-Seq_ESCs_Mouse1.54509799
24IGF1R_20145208_ChIP-Seq_DFB_Human1.52636908
25FUS_26573619_Chip-Seq_HEK293_Human1.49455148
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44933106
27* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43718494
28* RING1B_27294783_Chip-Seq_NPCs_Mouse1.43621771
29* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.42790322
30ZNF274_21170338_ChIP-Seq_K562_Hela1.38772214
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.37085577
32* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35101853
33* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34118434
34* EED_16625203_ChIP-ChIP_MESCs_Mouse1.31471051
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30379901
36* EZH2_27304074_Chip-Seq_ESCs_Mouse1.30188551
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29684389
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.28041813
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.27565650
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26737079
41CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26726774
42IRF1_19129219_ChIP-ChIP_H3396_Human1.26233292
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.25706928
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24249138
45* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21941454
46TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21864725
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21372467
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21094274
49AR_21572438_ChIP-Seq_LNCaP_Human1.20343401
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.20309142
51STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19924421
52* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19871003
53* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17523271
54* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17523271
55P300_19829295_ChIP-Seq_ESCs_Human1.17365599
56* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17214373
57EWS_26573619_Chip-Seq_HEK293_Human1.17102319
58* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16046773
59* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16024093
60* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15982973
61* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15937894
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15765692
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15756943
64* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15666577
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14565717
66* EZH2_27294783_Chip-Seq_ESCs_Mouse1.14478465
67* CBX2_27304074_Chip-Seq_ESCs_Mouse1.13165625
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11638742
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11366208
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11034391
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09377152
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08974252
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08129117
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08129117
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07728474
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.07642167
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07396703
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.06985426
79ER_23166858_ChIP-Seq_MCF-7_Human1.06957156
80STAT3_23295773_ChIP-Seq_U87_Human1.06174689
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05035355
82* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03876319
83AR_25329375_ChIP-Seq_VCAP_Human1.03873424
84RARB_27405468_Chip-Seq_BRAIN_Mouse1.03172543
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02799154
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01773168
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01440145
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01140034
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00755430
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00367300
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99553317
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98860662
93* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97977772
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97960941
95SOX2_21211035_ChIP-Seq_LN229_Gbm0.97497326
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97438273
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97292151
98VDR_22108803_ChIP-Seq_LS180_Human0.97219963
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96619630
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95998770
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95512431
102SALL1_21062744_ChIP-ChIP_HESCs_Human0.95220552
103* AR_19668381_ChIP-Seq_PC3_Human0.95189443
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95005739
105EZH2_27294783_Chip-Seq_NPCs_Mouse0.94682309
106* HNF4A_19822575_ChIP-Seq_HepG2_Human0.93689128
107* REST_21632747_ChIP-Seq_MESCs_Mouse0.92511442
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91943680
109SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91564465
110CMYC_18555785_Chip-Seq_ESCs_Mouse0.90806529
111* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90711829
112RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90558958
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90256587
114P53_22387025_ChIP-Seq_ESCs_Mouse0.89547493
115* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89249548
116P300_18555785_Chip-Seq_ESCs_Mouse0.89092639
117NANOG_18555785_Chip-Seq_ESCs_Mouse0.88948244
118TCF4_23295773_ChIP-Seq_U87_Human0.88372118
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87817528
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87706180
121* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87590003
122* CBP_20019798_ChIP-Seq_JUKART_Human0.87590003
123EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.87429562
124STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87244325
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.87077351
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.87049123
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86905697
128ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86487166
129DROSHA_22980978_ChIP-Seq_HELA_Human0.85887301
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85331870
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85034012
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84788258
133SMAD4_21799915_ChIP-Seq_A2780_Human0.84550901
134* TAL1_26923725_Chip-Seq_HPCs_Mouse0.84357644
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.82493439
136CDX2_20551321_ChIP-Seq_CACO-2_Human0.81735256
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81353248
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81353248
139KDM2B_26808549_Chip-Seq_REH_Human0.80581816
140BCAT_22108803_ChIP-Seq_LS180_Human0.80547058
141PCGF2_27294783_Chip-Seq_NPCs_Mouse0.78637305
142* RNF2_27304074_Chip-Seq_NSC_Mouse0.78382544
143* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78377578
144CRX_20693478_ChIP-Seq_RETINA_Mouse0.78156136
145SMAD1_18555785_Chip-Seq_ESCs_Mouse0.77759929
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.77668186
147OCT4_18555785_Chip-Seq_ESCs_Mouse0.77565311
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77393799
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76829558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.56338464
2MP0005360_urolithiasis6.91688797
3MP0005085_abnormal_gallbladder_physiolo6.00832719
4MP0005365_abnormal_bile_salt5.32054979
5MP0008875_abnormal_xenobiotic_pharmacok4.85134131
6MP0003252_abnormal_bile_duct3.67341886
7MP0001188_hyperpigmentation3.45854256
8MP0005083_abnormal_biliary_tract3.36482327
9MP0003806_abnormal_nucleotide_metabolis3.28860326
10MP0003195_calcinosis2.94848635
11MP0010329_abnormal_lipoprotein_level2.94701613
12MP0001666_abnormal_nutrient_absorption2.71568220
13MP0003787_abnormal_imprinting2.60425218
14MP0005423_abnormal_somatic_nervous2.56277911
15MP0003122_maternal_imprinting2.43023850
16MP0005332_abnormal_amino_acid2.30264873
17MP0002909_abnormal_adrenal_gland2.23918738
18MP0005451_abnormal_body_composition2.18334371
19MP0005646_abnormal_pituitary_gland2.17931727
20MP0005187_abnormal_penis_morphology2.15227551
21MP0009840_abnormal_foam_cell2.13668709
22MP0003868_abnormal_feces_composition2.06874215
23MP0003123_paternal_imprinting2.05528801
24MP0003121_genomic_imprinting2.02645352
25MP0004019_abnormal_vitamin_homeostasis2.01731945
26MP0000955_abnormal_spinal_cord1.96859852
27MP0003890_abnormal_embryonic-extraembry1.84803237
28MP0002118_abnormal_lipid_homeostasis1.84273697
29MP0005645_abnormal_hypothalamus_physiol1.82954816
30MP0003635_abnormal_synaptic_transmissio1.80415592
31MP0004859_abnormal_synaptic_plasticity1.75080258
32MP0003011_delayed_dark_adaptation1.74566087
33MP0002184_abnormal_innervation1.73282145
34MP0000631_abnormal_neuroendocrine_gland1.70576859
35MP0009379_abnormal_foot_pigmentation1.69333813
36MP0002138_abnormal_hepatobiliary_system1.66255742
37MP0002557_abnormal_social/conspecific_i1.61409966
38MP0005499_abnormal_olfactory_system1.61333144
39MP0005394_taste/olfaction_phenotype1.61333144
40MP0000609_abnormal_liver_physiology1.59397065
41MP0004133_heterotaxia1.57880756
42MP0009697_abnormal_copulation1.53879798
43MP0002063_abnormal_learning/memory/cond1.52430442
44MP0005386_behavior/neurological_phenoty1.50776646
45MP0004924_abnormal_behavior1.50776646
46MP0009046_muscle_twitch1.48578867
47MP0003315_abnormal_perineum_morphology1.44932063
48MP0003880_abnormal_central_pattern1.42636000
49MP0002882_abnormal_neuron_morphology1.41950361
50MP0000566_synostosis1.37070946
51MP0003191_abnormal_cellular_cholesterol1.36163358
52MP0001970_abnormal_pain_threshold1.34985202
53MP0005084_abnormal_gallbladder_morpholo1.34957244
54MP0001986_abnormal_taste_sensitivity1.33883239
55MP0004811_abnormal_neuron_physiology1.32861688
56MP0008789_abnormal_olfactory_epithelium1.32106126
57MP0002733_abnormal_thermal_nociception1.30895107
58MP0003690_abnormal_glial_cell1.29618584
59MP0002752_abnormal_somatic_nervous1.29133573
60MP0002638_abnormal_pupillary_reflex1.27635587
61MP0006292_abnormal_olfactory_placode1.27342574
62MP0004270_analgesia1.25262930
63MP0000920_abnormal_myelination1.25121620
64MP0005584_abnormal_enzyme/coenzyme_acti1.24323060
65MP0003861_abnormal_nervous_system1.22412307
66MP0005319_abnormal_enzyme/_coenzyme1.21229378
67MP0003329_amyloid_beta_deposits1.19661414
68MP0002067_abnormal_sensory_capabilities1.18786462
69MP0004145_abnormal_muscle_electrophysio1.18362328
70MP0002822_catalepsy1.16968896
71MP0001764_abnormal_homeostasis1.14744327
72MP0000604_amyloidosis1.14108978
73MP0002152_abnormal_brain_morphology1.12851973
74MP0003119_abnormal_digestive_system1.11909340
75MP0003283_abnormal_digestive_organ1.11877514
76MP0002751_abnormal_autonomic_nervous1.08065785
77MP0002876_abnormal_thyroid_physiology1.07261475
78MP0005408_hypopigmentation1.05944446
79MP0006276_abnormal_autonomic_nervous1.04409806
80MP0000462_abnormal_digestive_system1.03853834
81MP0010386_abnormal_urinary_bladder1.02519031
82MP0000534_abnormal_ureter_morphology0.98153371
83MP0003656_abnormal_erythrocyte_physiolo0.97571214
84MP0001919_abnormal_reproductive_system0.87733074
85MP0002697_abnormal_eye_size0.86854569
86MP0009764_decreased_sensitivity_to0.85624750
87MP0003942_abnormal_urinary_system0.84653222
88MP0004381_abnormal_hair_follicle0.84366012
89MP0001486_abnormal_startle_reflex0.83486322
90MP0002653_abnormal_ependyma_morphology0.81951587
91MP0009765_abnormal_xenobiotic_induced0.81687872
92MP0005220_abnormal_exocrine_pancreas0.81665129
93MP0001286_abnormal_eye_development0.81159325
94MP0001502_abnormal_circadian_rhythm0.81152127
95MP0002163_abnormal_gland_morphology0.80575527
96MP0001529_abnormal_vocalization0.80442007
97MP0009643_abnormal_urine_homeostasis0.78817892
98MP0009053_abnormal_anal_canal0.78307589
99MP0002066_abnormal_motor_capabilities/c0.78013663
100* MP0002928_abnormal_bile_duct0.77559371
101MP0002234_abnormal_pharynx_morphology0.76789929
102MP0008995_early_reproductive_senescence0.76649073
103MP0002081_perinatal_lethality0.76215543
104MP0005636_abnormal_mineral_homeostasis0.75835577
105MP0005647_abnormal_sex_gland0.74707333
106MP0000778_abnormal_nervous_system0.73508938
107MP0004742_abnormal_vestibular_system0.72779703
108MP0001944_abnormal_pancreas_morphology0.72204231
109MP0003385_abnormal_body_wall0.71191413
110MP0001485_abnormal_pinna_reflex0.71016598
111MP0001661_extended_life_span0.69727840
112MP0002233_abnormal_nose_morphology0.69138763
113MP0003632_abnormal_nervous_system0.69053768
114MP0005389_reproductive_system_phenotype0.68954432
115MP0004142_abnormal_muscle_tone0.68889447
116MP0002102_abnormal_ear_morphology0.68719872
117MP0005409_darkened_coat_color0.67745953
118MP0005551_abnormal_eye_electrophysiolog0.67441717
119MP0009642_abnormal_blood_homeostasis0.67044400
120MP0009763_increased_sensitivity_to0.65700256
121* MP0000598_abnormal_liver_morphology0.65023895
122MP0002229_neurodegeneration0.64563455
123MP0005535_abnormal_body_temperature0.62214539
124MP0002078_abnormal_glucose_homeostasis0.61792183
125MP0005376_homeostasis/metabolism_phenot0.61034623
126MP0002272_abnormal_nervous_system0.61017438
127MP0004883_abnormal_blood_vessel0.59906799
128MP0008874_decreased_physiological_sensi0.58960166
129MP0003718_maternal_effect0.57773471
130MP0005334_abnormal_fat_pad0.56836351
131MP0004147_increased_porphyrin_level0.56780564
132MP0002735_abnormal_chemical_nociception0.54163347
133MP0003186_abnormal_redox_activity0.53485189
134MP0009745_abnormal_behavioral_response0.52887472
135MP0000579_abnormal_nail_morphology0.51892270
136MP0001905_abnormal_dopamine_level0.51687043
137MP0005448_abnormal_energy_balance0.51189617
138MP0008469_abnormal_protein_level0.50314237
139MP0002734_abnormal_mechanical_nocicepti0.49401152
140MP0006035_abnormal_mitochondrial_morpho0.49238133
141MP0001968_abnormal_touch/_nociception0.48992738
142MP0008872_abnormal_physiological_respon0.48884584
143MP0001664_abnormal_digestion0.47991076
144MP0006036_abnormal_mitochondrial_physio0.47775694
145MP0000538_abnormal_urinary_bladder0.47069340
146MP0005395_other_phenotype0.46143087
147MP0001324_abnormal_eye_pigmentation0.44923437
148MP0000639_abnormal_adrenal_gland0.44104430
149MP0000427_abnormal_hair_cycle0.43602426
150MP0002064_seizures0.43259917
151MP0005379_endocrine/exocrine_gland_phen0.43165911
152MP0004885_abnormal_endolymph0.42751614
153MP0002572_abnormal_emotion/affect_behav0.42464753
154MP0002971_abnormal_brown_adipose0.42313324
155MP0002254_reproductive_system_inflammat0.42123361
156MP0001984_abnormal_olfaction0.41882410
157MP0002069_abnormal_eating/drinking_beha0.39608145
158MP0005195_abnormal_posterior_eye0.39496465
159MP0001440_abnormal_grooming_behavior0.39455368
160MP0003938_abnormal_ear_development0.38772672

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.26026483
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.82507337
3Deep venous thrombosis (HP:0002625)6.79909430
4Prolonged partial thromboplastin time (HP:0003645)6.41726476
5Hypobetalipoproteinemia (HP:0003563)6.19893590
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.89010149
7Xanthomatosis (HP:0000991)5.48062111
8Hyperlipoproteinemia (HP:0010980)5.05525431
9Complement deficiency (HP:0004431)4.64842334
10Conjugated hyperbilirubinemia (HP:0002908)4.57630919
11Epidermoid cyst (HP:0200040)4.36698220
12Joint hemorrhage (HP:0005261)4.35179359
13Fat malabsorption (HP:0002630)4.19062809
14Progressive cerebellar ataxia (HP:0002073)4.13781864
15Hypolipoproteinemia (HP:0010981)4.07502530
16Limb dystonia (HP:0002451)3.98195870
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.87508986
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.79277870
19Myokymia (HP:0002411)3.75984099
20Hyperglycinemia (HP:0002154)3.72508008
21Abnormality of methionine metabolism (HP:0010901)3.71368864
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.67464633
23Abnormality of the common coagulation pathway (HP:0010990)3.67311625
24Hyperammonemia (HP:0001987)3.55857529
25Abnormal pancreas size (HP:0012094)3.55780931
26Genetic anticipation (HP:0003743)3.47083554
27Drooling (HP:0002307)3.46085189
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.43621522
29Ketosis (HP:0001946)3.40716939
30Exotropia (HP:0000577)3.40420463
31Hypercholesterolemia (HP:0003124)3.40051953
32Osteomalacia (HP:0002749)3.32574692
33Broad-based gait (HP:0002136)3.28404248
34Abnormality of glycine metabolism (HP:0010895)3.27194788
35Abnormality of serine family amino acid metabolism (HP:0010894)3.27194788
36Agitation (HP:0000713)3.20202690
37Abnormality of complement system (HP:0005339)3.18686991
38Shawl scrotum (HP:0000049)3.15579447
39Excessive salivation (HP:0003781)3.13121099
40Hyperglycinuria (HP:0003108)3.10222590
41Focal seizures (HP:0007359)3.06561804
42Lissencephaly (HP:0001339)3.04489311
43Acanthocytosis (HP:0001927)3.03988721
44Steatorrhea (HP:0002570)3.02007526
45Hypoalphalipoproteinemia (HP:0003233)3.01563606
46Abnormality of pyrimidine metabolism (HP:0004353)2.99779198
47Hyperbilirubinemia (HP:0002904)2.90515207
48Torticollis (HP:0000473)2.89233930
49Abnormality of the intrinsic pathway (HP:0010989)2.86707441
50Pachygyria (HP:0001302)2.82824627
51Parakeratosis (HP:0001036)2.81001458
52Hypoglycemic coma (HP:0001325)2.76571532
53Cerebral edema (HP:0002181)2.75874101
54High anterior hairline (HP:0009890)2.75270516
55Cortical dysplasia (HP:0002539)2.73584908
56Spontaneous abortion (HP:0005268)2.69868044
57Hypophosphatemic rickets (HP:0004912)2.67468419
58Epileptic encephalopathy (HP:0200134)2.63848944
59Sensory axonal neuropathy (HP:0003390)2.61290252
60Hypoplasia of the brainstem (HP:0002365)2.56219730
61Aplasia/Hypoplasia of the brainstem (HP:0007362)2.56219730
62Amblyopia (HP:0000646)2.56145545
63Febrile seizures (HP:0002373)2.55730363
64Delayed CNS myelination (HP:0002188)2.53246316
65Vascular calcification (HP:0004934)2.52112970
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.50724185
67Hepatoblastoma (HP:0002884)2.50134685
68Skin nodule (HP:0200036)2.49711148
69Lethargy (HP:0001254)2.48150738
70Abnormality of serum amino acid levels (HP:0003112)2.47670587
71Hypochromic microcytic anemia (HP:0004840)2.47592391
72Gait imbalance (HP:0002141)2.46879247
73Metabolic acidosis (HP:0001942)2.46171622
74Protruding tongue (HP:0010808)2.42097878
75Abnormality of fatty-acid metabolism (HP:0004359)2.39640394
76Neurofibrillary tangles (HP:0002185)2.36948018
77Abnormality of nucleobase metabolism (HP:0010932)2.35331070
78Volvulus (HP:0002580)2.32539470
79Rickets (HP:0002748)2.31781909
80Oligodactyly (hands) (HP:0001180)2.29770404
81Fair hair (HP:0002286)2.27173462
82Spastic paraparesis (HP:0002313)2.26805094
83Glomerulonephritis (HP:0000099)2.24135219
84Macroorchidism (HP:0000053)2.23175603
85Ketoacidosis (HP:0001993)2.22481989
86Chronic hepatic failure (HP:0100626)2.21782083
87Amyloidosis (HP:0011034)2.20467809
88Abnormal gallbladder morphology (HP:0012437)2.20371565
89Degeneration of the lateral corticospinal tracts (HP:0002314)2.19855766
90Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19855766
91Hepatocellular carcinoma (HP:0001402)2.19484382
92Glycosuria (HP:0003076)2.18973941
93Abnormality of urine glucose concentration (HP:0011016)2.18973941
94Diastasis recti (HP:0001540)2.18879945
95Abnormality of the corticospinal tract (HP:0002492)2.18374282
96Abnormality of midbrain morphology (HP:0002418)2.15897589
97Molar tooth sign on MRI (HP:0002419)2.15897589
98Enlarged kidneys (HP:0000105)2.15589572
99Cardiovascular calcification (HP:0011915)2.12980937
100Pendular nystagmus (HP:0012043)2.10700581
101Urinary bladder sphincter dysfunction (HP:0002839)2.09709076
102Malnutrition (HP:0004395)2.08173200
103Abnormal gallbladder physiology (HP:0012438)2.07875112
104Cholecystitis (HP:0001082)2.07875112
105Hyperventilation (HP:0002883)2.06864571
106Abnormality of the intervertebral disk (HP:0005108)2.06617742
107Increased serum pyruvate (HP:0003542)2.06597769
108Abnormality of glycolysis (HP:0004366)2.06597769
109Nephronophthisis (HP:0000090)2.05778454
110Focal dystonia (HP:0004373)2.05219972
111Morphological abnormality of the pyramidal tract (HP:0002062)2.05190566
112Craniofacial dystonia (HP:0012179)2.04939738
113Irritability (HP:0000737)2.04202029
114Impaired vibration sensation in the lower limbs (HP:0002166)2.04120594
115Hypoglycemic seizures (HP:0002173)2.03798212
116Mitral stenosis (HP:0001718)2.03428508
117Abnormality of purine metabolism (HP:0004352)2.03107006
118Retinal dysplasia (HP:0007973)2.02636198
119Obsessive-compulsive behavior (HP:0000722)2.01037264
120Atonic seizures (HP:0010819)1.97686134
121Gingival bleeding (HP:0000225)1.96654672
122Polyphagia (HP:0002591)1.96579838
123Acute encephalopathy (HP:0006846)1.94694856
124Anxiety (HP:0000739)1.94414579
125Vaginal atresia (HP:0000148)1.94225263
126Hypothermia (HP:0002045)1.94177188
127Cholelithiasis (HP:0001081)1.93409982
128Medial flaring of the eyebrow (HP:0010747)1.93100068
129Abnormality of vitamin metabolism (HP:0100508)1.91911514
130Congenital primary aphakia (HP:0007707)1.91059826
131Renal Fanconi syndrome (HP:0001994)1.90073194
132Myocardial infarction (HP:0001658)1.89581813
133Renal hypoplasia (HP:0000089)1.88969281
134Vomiting (HP:0002013)1.88223434
135Polymicrogyria (HP:0002126)1.87889996
136Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87020499
137Dicarboxylic aciduria (HP:0003215)1.87020499
138Hypsarrhythmia (HP:0002521)1.86997252
139Incomplete penetrance (HP:0003829)1.85947263
140Genital tract atresia (HP:0001827)1.85945422
141Hemorrhage of the eye (HP:0011885)1.85895553
142Ileus (HP:0002595)1.85398252
143Poikilocytosis (HP:0004447)1.84270039
144Aqueductal stenosis (HP:0002410)1.84034156
145Menorrhagia (HP:0000132)1.83521148
146Poor coordination (HP:0002370)1.83411370
147Pheochromocytoma (HP:0002666)1.83316892
148Systemic lupus erythematosus (HP:0002725)1.82947540
149Labial hypoplasia (HP:0000066)1.82494316
150EEG with generalized epileptiform discharges (HP:0011198)1.82213410
151Epileptiform EEG discharges (HP:0011182)1.81834806
152Sensorimotor neuropathy (HP:0007141)1.81233803
153Anencephaly (HP:0002323)1.80436560
154Opisthotonus (HP:0002179)1.80135087
155True hermaphroditism (HP:0010459)1.79072797
156Abnormality of the aortic arch (HP:0012303)1.78704632
157Midline defect of the nose (HP:0004122)1.78522702
158Neonatal onset (HP:0003623)1.78208522
159Delayed myelination (HP:0012448)1.78064764
160Cerebral hemorrhage (HP:0001342)1.77944173
161Dialeptic seizures (HP:0011146)1.77552259
162Brushfield spots (HP:0001088)1.76798447
163Nephrogenic diabetes insipidus (HP:0009806)1.76139754
164Abnormality of the renal medulla (HP:0100957)1.75509524
165Pancreatic cysts (HP:0001737)1.75278696
166Abnormality of the gallbladder (HP:0005264)1.74566598
167Specific learning disability (HP:0001328)1.74082949
168Pancreatitis (HP:0001733)1.73873653
169Down-sloping shoulders (HP:0200021)1.73647814
170Absence seizures (HP:0002121)1.73206316
171Absent eyebrow (HP:0002223)1.73161683
172Abnormality of placental membranes (HP:0011409)1.71368028
173Amniotic constriction ring (HP:0009775)1.71368028
174Spastic tetraplegia (HP:0002510)1.70955203
175Abnormal respiratory epithelium morphology (HP:0012253)1.70853511
176Abnormal respiratory motile cilium morphology (HP:0005938)1.70853511
177Pancreatic fibrosis (HP:0100732)1.70713285
178Inappropriate behavior (HP:0000719)1.70003041
179Anophthalmia (HP:0000528)1.68104364
180Hemiparesis (HP:0001269)1.67889279
181Abnormality of salivation (HP:0100755)1.67774186
182Truncal obesity (HP:0001956)1.66249129
183Partial agenesis of the corpus callosum (HP:0001338)1.66037180
184Abnormal urine phosphate concentration (HP:0012599)1.65268959
185Hyperphosphaturia (HP:0003109)1.63925500
186Heterotopia (HP:0002282)1.63542437
187Urinary urgency (HP:0000012)1.62958463
188Focal motor seizures (HP:0011153)1.62546415
189Cystic liver disease (HP:0006706)1.62392224
190Meningocele (HP:0002435)1.62190887
191Patellar aplasia (HP:0006443)1.61692064
192Fetal akinesia sequence (HP:0001989)1.60833152
193Hypoplastic female external genitalia (HP:0012815)1.58727675
194Enlarged penis (HP:0000040)1.57509880
195Poor suck (HP:0002033)1.57332758
196Intellectual disability, moderate (HP:0002342)1.56828459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.49743036
2STK394.38492497
3SIK23.00879571
4OXSR12.87374336
5BCR2.53270776
6INSRR2.37404729
7CASK2.35516348
8ERBB42.30095902
9BCKDK2.04561127
10FGFR22.03751297
11MARK11.98539870
12DYRK31.97046496
13EPHB11.93561805
14WNK41.92100402
15UHMK11.90056564
16FGFR41.85046220
17CSNK1G31.75741531
18CSNK1A1L1.71801566
19MAPK131.65549957
20EPHA41.64051344
21FRK1.63031924
22CSNK1G11.60921540
23TAOK31.58886078
24PBK1.58487960
25PKN11.56201294
26MAP2K41.55431884
27SIK11.50697717
28AKT31.44025141
29ICK1.43942832
30CAMK1G1.41323686
31CSNK1G21.41119170
32MST1R1.40007574
33SGK21.39648878
34STK161.33157281
35MET1.31965661
36EPHB21.25991372
37CAMK1D1.22714332
38CAMK2B1.22119219
39DYRK21.20479596
40CDK191.15795620
41NTRK31.12379832
42MAP3K91.09987063
43PAK61.08907210
44PKN21.05659902
45NEK61.03247196
46PAK31.02941911
47BMPR1B1.01365099
48CAMK2G0.97155971
49IRAK20.93031581
50RPS6KA20.92208287
51MAPK40.89586138
52ABL20.85955225
53FGR0.85506466
54ERBB20.83755685
55PRKCQ0.83487064
56WNK10.83371460
57LMTK20.83325768
58CAMK2A0.81520795
59MAP2K70.79812884
60PIK3CG0.77754226
61GRK10.74192424
62EPHA20.73376909
63MAPK150.73322704
64PRKCZ0.69545149
65CAMK2D0.69238556
66NUAK10.68925530
67SGK30.67944910
68MAP3K40.67825761
69SGK4940.63808263
70SGK2230.63808263
71CSNK1E0.63405037
72MAP3K120.62777619
73PRKCG0.62739462
74EPHA30.62362557
75DYRK1B0.60377909
76PRKAA10.60235160
77PRKAA20.60226369
78DAPK20.58834022
79CDK50.58770566
80CAMKK10.58232582
81PNCK0.58038983
82NTRK10.56001607
83PRKCH0.55043166
84GSK3A0.53819470
85PASK0.53381544
86CAMK40.51777793
87MAP3K60.51054151
88PRKACG0.50331521
89PINK10.50102133
90NTRK20.49292209
91IRAK10.48913389
92PRPF4B0.48373364
93MAPK110.48213386
94LATS20.45866040
95PRKCE0.45166214
96MAP3K140.44155411
97STK110.43634132
98FLT30.43620971
99PRKG10.43355337
100CDK140.43212905
101BLK0.43153324
102MARK20.43075171
103WNK30.43057526
104GRK50.42904792
105MAP3K70.42722830
106MINK10.42470087
107ADRBK10.42330122
108PHKG20.41873310
109PHKG10.41873310
110PRKACA0.41850838
111ROCK20.40738963
112ERBB30.40094286
113NLK0.40076124
114FYN0.39834669
115ADRBK20.39185113
116MAP3K100.38445224
117DYRK1A0.38309403
118CDK150.37915816
119MKNK20.37046391
120CDK180.36641309
121PRKDC0.36133628
122CDK11A0.36020624
123SGK10.35142709
124PIK3CA0.34520974
125TLK10.34425706
126TYRO30.33866142
127ROCK10.33742881
128GSK3B0.33115210
129MAPK80.32775168
130FGFR10.31535870
131CAMK10.30494783
132CSNK1D0.29782801
133RPS6KA60.29125061
134NEK20.29115353
135RET0.28737075
136MAPK90.28234603
137CAMKK20.27967507
138KSR10.27402899
139MAPK140.27155315

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.26757299
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.08446578
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.01856000
4Nitrogen metabolism_Homo sapiens_hsa009102.97975025
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.80921889
6Arginine biosynthesis_Homo sapiens_hsa002202.63240331
7Complement and coagulation cascades_Homo sapiens_hsa046102.62046354
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.59141716
9Tryptophan metabolism_Homo sapiens_hsa003802.58196423
10Steroid biosynthesis_Homo sapiens_hsa001002.56348575
11Butanoate metabolism_Homo sapiens_hsa006502.44924226
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32012164
13Cocaine addiction_Homo sapiens_hsa050302.27901485
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.27346296
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23771352
16Fatty acid degradation_Homo sapiens_hsa000712.22713222
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20068037
18Steroid hormone biosynthesis_Homo sapiens_hsa001402.17774551
19Fatty acid elongation_Homo sapiens_hsa000622.12793032
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.10314666
21Dopaminergic synapse_Homo sapiens_hsa047282.09298962
22Peroxisome_Homo sapiens_hsa041462.08842209
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98140996
24Chemical carcinogenesis_Homo sapiens_hsa052041.97074057
25Histidine metabolism_Homo sapiens_hsa003401.94890536
26Cholinergic synapse_Homo sapiens_hsa047251.91057052
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.82980831
28Morphine addiction_Homo sapiens_hsa050321.82834059
29Retinol metabolism_Homo sapiens_hsa008301.82621771
30Fatty acid metabolism_Homo sapiens_hsa012121.81409699
31Propanoate metabolism_Homo sapiens_hsa006401.75870482
32Sulfur metabolism_Homo sapiens_hsa009201.72522317
33PPAR signaling pathway_Homo sapiens_hsa033201.72071741
34Synaptic vesicle cycle_Homo sapiens_hsa047211.71264761
35Circadian entrainment_Homo sapiens_hsa047131.70591223
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66335797
37Cardiac muscle contraction_Homo sapiens_hsa042601.61106553
38beta-Alanine metabolism_Homo sapiens_hsa004101.60158010
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59391443
40Caffeine metabolism_Homo sapiens_hsa002321.59310148
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.57524806
42Staphylococcus aureus infection_Homo sapiens_hsa051501.55594676
43Type II diabetes mellitus_Homo sapiens_hsa049301.53141428
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.52604663
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50466534
46Phototransduction_Homo sapiens_hsa047441.44362853
47Bile secretion_Homo sapiens_hsa049761.43663809
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43457049
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39634689
50Fat digestion and absorption_Homo sapiens_hsa049751.39166330
51Tyrosine metabolism_Homo sapiens_hsa003501.36260102
52Phenylalanine metabolism_Homo sapiens_hsa003601.31992306
53Taste transduction_Homo sapiens_hsa047421.31242705
54Insulin secretion_Homo sapiens_hsa049111.27515650
55Starch and sucrose metabolism_Homo sapiens_hsa005001.25528441
56ABC transporters_Homo sapiens_hsa020101.22990537
57Pyruvate metabolism_Homo sapiens_hsa006201.20501343
58Basal cell carcinoma_Homo sapiens_hsa052171.19839639
59Selenocompound metabolism_Homo sapiens_hsa004501.05594420
60Arginine and proline metabolism_Homo sapiens_hsa003301.04281007
61Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03602637
62Hedgehog signaling pathway_Homo sapiens_hsa043401.01260604
63Folate biosynthesis_Homo sapiens_hsa007901.00259261
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98236349
65Vitamin digestion and absorption_Homo sapiens_hsa049770.96242193
66Amphetamine addiction_Homo sapiens_hsa050310.95454838
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.94732273
68Gap junction_Homo sapiens_hsa045400.87510890
69Long-term depression_Homo sapiens_hsa047300.87434075
70ErbB signaling pathway_Homo sapiens_hsa040120.85389774
71Glutathione metabolism_Homo sapiens_hsa004800.82676370
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80906662
73Vitamin B6 metabolism_Homo sapiens_hsa007500.80642406
74Endometrial cancer_Homo sapiens_hsa052130.80374728
75Colorectal cancer_Homo sapiens_hsa052100.78081602
76Hippo signaling pathway_Homo sapiens_hsa043900.77378996
77Wnt signaling pathway_Homo sapiens_hsa043100.76907630
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76670719
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75750551
80Alcoholism_Homo sapiens_hsa050340.70867101
81Melanogenesis_Homo sapiens_hsa049160.70480304
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69784291
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69346482
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68161760
85AMPK signaling pathway_Homo sapiens_hsa041520.65586629
86Olfactory transduction_Homo sapiens_hsa047400.64987127
87Carbon metabolism_Homo sapiens_hsa012000.64291117
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.61033251
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60791814
90Lysine degradation_Homo sapiens_hsa003100.60173349
91Glycerolipid metabolism_Homo sapiens_hsa005610.59126504
92Thyroid hormone synthesis_Homo sapiens_hsa049180.58044779
93cAMP signaling pathway_Homo sapiens_hsa040240.57485175
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56648416
95Biosynthesis of amino acids_Homo sapiens_hsa012300.56625371
96Sulfur relay system_Homo sapiens_hsa041220.56497603
97Ether lipid metabolism_Homo sapiens_hsa005650.56445373
98Metabolic pathways_Homo sapiens_hsa011000.56273905
99Fatty acid biosynthesis_Homo sapiens_hsa000610.55663742
100Oxidative phosphorylation_Homo sapiens_hsa001900.55064159
101Prolactin signaling pathway_Homo sapiens_hsa049170.52839092
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50492813
103Rap1 signaling pathway_Homo sapiens_hsa040150.49230095
104Linoleic acid metabolism_Homo sapiens_hsa005910.48496927
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48399684
106Oxytocin signaling pathway_Homo sapiens_hsa049210.48017804
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46975464
108Gastric acid secretion_Homo sapiens_hsa049710.46311163
109Ras signaling pathway_Homo sapiens_hsa040140.44496985
110MAPK signaling pathway_Homo sapiens_hsa040100.42792025
111Estrogen signaling pathway_Homo sapiens_hsa049150.42677734
112Circadian rhythm_Homo sapiens_hsa047100.42452224
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40339227
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40324967
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40160852
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40095051
117Thyroid cancer_Homo sapiens_hsa052160.39103860
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37414195
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34097157
120Alzheimers disease_Homo sapiens_hsa050100.32717968
121Parkinsons disease_Homo sapiens_hsa050120.29763028
122Axon guidance_Homo sapiens_hsa043600.27123575
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.23055518
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21945538
125Prion diseases_Homo sapiens_hsa050200.21549209
126Ovarian steroidogenesis_Homo sapiens_hsa049130.18267194
127Pentose phosphate pathway_Homo sapiens_hsa000300.17110951
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12548581
129Arachidonic acid metabolism_Homo sapiens_hsa005900.07475501
130Nicotine addiction_Homo sapiens_hsa050330.04497807
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.03447352
132Protein export_Homo sapiens_hsa030600.02720609
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.02250070
134Regulation of autophagy_Homo sapiens_hsa041400.00725334
135GABAergic synapse_Homo sapiens_hsa047270.00530778
136Fructose and mannose metabolism_Homo sapiens_hsa00051-0.1002512
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0999177
138Insulin resistance_Homo sapiens_hsa04931-0.0913674
139Retrograde endocannabinoid signaling_Homo sapiens_hsa04723-0.0883170
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0596141
141Mineral absorption_Homo sapiens_hsa04978-0.0583636
142Galactose metabolism_Homo sapiens_hsa00052-0.0521691
143Serotonergic synapse_Homo sapiens_hsa04726-0.0482477
144Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0310220
145Glutamatergic synapse_Homo sapiens_hsa04724-0.0276763
146Sphingolipid metabolism_Homo sapiens_hsa00600-0.0173064
147Huntingtons disease_Homo sapiens_hsa05016-0.0162217
148One carbon pool by folate_Homo sapiens_hsa00670-0.0051186

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