ONECUT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1superoxide anion generation (GO:0042554)4.53093606
2microtubule depolymerization (GO:0007019)4.17435063
3peripheral nervous system neuron development (GO:0048935)4.05130551
4protein polyglutamylation (GO:0018095)4.04937862
5presynaptic membrane assembly (GO:0097105)3.99766720
6pyrimidine nucleobase catabolic process (GO:0006208)3.89696792
7behavioral response to ethanol (GO:0048149)3.71394312
8presynaptic membrane organization (GO:0097090)3.69249845
9tachykinin receptor signaling pathway (GO:0007217)3.67846917
10neuron cell-cell adhesion (GO:0007158)3.57618153
11polyketide metabolic process (GO:0030638)3.54286908
12doxorubicin metabolic process (GO:0044598)3.54286908
13daunorubicin metabolic process (GO:0044597)3.54286908
14negative regulation of cytosolic calcium ion concentration (GO:0051481)3.52938484
15neurofilament cytoskeleton organization (GO:0060052)3.48687690
16adenosine metabolic process (GO:0046085)3.47444089
17gamma-aminobutyric acid transport (GO:0015812)3.46180565
18detection of light stimulus involved in visual perception (GO:0050908)3.41298064
19detection of light stimulus involved in sensory perception (GO:0050962)3.41298064
20L-fucose catabolic process (GO:0042355)3.40411459
21fucose catabolic process (GO:0019317)3.40411459
22L-fucose metabolic process (GO:0042354)3.40411459
23positive regulation of protein homodimerization activity (GO:0090073)3.39977029
24substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.37387794
25substrate-independent telencephalic tangential migration (GO:0021826)3.37387794
26cerebral cortex radially oriented cell migration (GO:0021799)3.33830955
27peristalsis (GO:0030432)3.32696087
28synaptic transmission, cholinergic (GO:0007271)3.29958731
29nucleobase catabolic process (GO:0046113)3.27690847
30keratinocyte development (GO:0003334)3.27137612
31epithelial cilium movement (GO:0003351)3.27082972
32regulation of timing of cell differentiation (GO:0048505)3.26765998
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25529744
34positive regulation of cellular amide metabolic process (GO:0034250)3.25062771
35postsynaptic membrane organization (GO:0001941)3.24350393
36opioid receptor signaling pathway (GO:0038003)3.23476879
37startle response (GO:0001964)3.21395624
38transmission of nerve impulse (GO:0019226)3.20214839
39response to pheromone (GO:0019236)3.11704790
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11650107
41G-protein coupled receptor internalization (GO:0002031)3.09622279
42cell proliferation in forebrain (GO:0021846)3.09432120
43sympathetic nervous system development (GO:0048485)3.08435642
44regulation of neurotransmitter uptake (GO:0051580)3.08174715
45mesenchymal cell differentiation involved in renal system development (GO:2001012)3.02010844
46mesenchymal cell differentiation involved in kidney development (GO:0072161)3.02010844
47cornea development in camera-type eye (GO:0061303)3.00378360
48auditory behavior (GO:0031223)2.98301519
49regulation of action potential (GO:0098900)2.97862320
50neuronal action potential propagation (GO:0019227)2.96680967
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.95694905
52kidney morphogenesis (GO:0060993)2.94339908
53kynurenine metabolic process (GO:0070189)2.92744386
54indolalkylamine metabolic process (GO:0006586)2.92260518
55tryptophan catabolic process (GO:0006569)2.92220671
56indole-containing compound catabolic process (GO:0042436)2.92220671
57indolalkylamine catabolic process (GO:0046218)2.92220671
58retinal ganglion cell axon guidance (GO:0031290)2.91537540
59adaptation of signaling pathway (GO:0023058)2.90361896
60positive regulation of uterine smooth muscle contraction (GO:0070474)2.89879332
61head development (GO:0060322)2.88252719
62protein localization to cilium (GO:0061512)2.86715164
63long-chain fatty acid biosynthetic process (GO:0042759)2.85958499
64cellular anion homeostasis (GO:0030002)2.85947439
65regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.83332116
66regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.83332116
67neural tube formation (GO:0001841)2.82093567
68neuromuscular synaptic transmission (GO:0007274)2.77360890
69regulation of activation of Janus kinase activity (GO:0010533)2.77053330
70somite development (GO:0061053)2.76916131
71positive regulation of synapse assembly (GO:0051965)2.75389157
72magnesium ion transport (GO:0015693)2.74778248
73cell differentiation involved in metanephros development (GO:0072202)2.74655145
74regulation of development, heterochronic (GO:0040034)2.74132085
75negative regulation of telomere maintenance (GO:0032205)2.72388013
76preassembly of GPI anchor in ER membrane (GO:0016254)2.71892461
77superoxide metabolic process (GO:0006801)2.70504917
78axoneme assembly (GO:0035082)2.69768635
79synapse assembly (GO:0007416)2.69703363
80negative regulation of mast cell activation (GO:0033004)2.69224067
81endoderm formation (GO:0001706)2.69029229
82water-soluble vitamin biosynthetic process (GO:0042364)2.68434284
83cellular response to ATP (GO:0071318)2.68239691
84DNA deamination (GO:0045006)2.67929214
85positive regulation of interleukin-1 beta secretion (GO:0050718)2.67474764
86centriole assembly (GO:0098534)2.66687521
87cranial nerve morphogenesis (GO:0021602)2.66611067
88glycerophospholipid catabolic process (GO:0046475)2.64526439
89behavioral response to nicotine (GO:0035095)2.64462114
90neuronal action potential (GO:0019228)2.62791023
91limb bud formation (GO:0060174)2.62542827
92cilium movement (GO:0003341)2.62053644
93dentate gyrus development (GO:0021542)2.60618470
94retina layer formation (GO:0010842)2.60289632
95central nervous system myelination (GO:0022010)2.60258515
96axon ensheathment in central nervous system (GO:0032291)2.60258515
97righting reflex (GO:0060013)2.59983280
98regulation of cilium movement (GO:0003352)2.59642836
99negative regulation of transcription regulatory region DNA binding (GO:2000678)2.59241355
100negative regulation of response to food (GO:0032096)2.56971020
101negative regulation of appetite (GO:0032099)2.56971020
102membrane depolarization during action potential (GO:0086010)2.55420842
103positive regulation of action potential (GO:0045760)2.55415674
104protein complex biogenesis (GO:0070271)2.55393665
105regulation of rhodopsin mediated signaling pathway (GO:0022400)2.55256856
106GPI anchor metabolic process (GO:0006505)2.54916828
107sulfation (GO:0051923)2.54838269
108spinal cord development (GO:0021510)2.53400009
109regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.52712193
110drinking behavior (GO:0042756)2.52557361
111axonal fasciculation (GO:0007413)2.50242237
112negative regulation of keratinocyte proliferation (GO:0010839)2.48812111
113mitochondrial respiratory chain complex I assembly (GO:0032981)2.47510395
114NADH dehydrogenase complex assembly (GO:0010257)2.47510395
115mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.47510395
116mechanosensory behavior (GO:0007638)2.47406040
117regulation of collateral sprouting (GO:0048670)2.46986776
118cell differentiation in spinal cord (GO:0021515)2.46577093
119establishment of protein localization to mitochondrial membrane (GO:0090151)2.46178467
120dendritic cell migration (GO:0036336)2.45987388
121negative regulation of homotypic cell-cell adhesion (GO:0034111)2.45137522
122ionotropic glutamate receptor signaling pathway (GO:0035235)2.44893175
123calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.44746649
124regulation of synapse assembly (GO:0051963)2.44614098
125positive regulation of mast cell degranulation (GO:0043306)2.44243196
126positive regulation of mast cell activation involved in immune response (GO:0033008)2.44243196
127microtubule polymerization or depolymerization (GO:0031109)2.44227001
128inner ear receptor stereocilium organization (GO:0060122)2.43525574
129positive regulation of interleukin-1 secretion (GO:0050716)2.43449788
130GPI anchor biosynthetic process (GO:0006506)2.43352809
131adult walking behavior (GO:0007628)2.42841179
132piRNA metabolic process (GO:0034587)2.42699232
133dendritic cell chemotaxis (GO:0002407)2.42496275
134regulation of synapse structural plasticity (GO:0051823)2.41860673
135vocalization behavior (GO:0071625)2.41437465
136tryptophan metabolic process (GO:0006568)2.41332495
137regulation of non-canonical Wnt signaling pathway (GO:2000050)2.41137576
138rhodopsin mediated signaling pathway (GO:0016056)2.40752501
139developmental pigmentation (GO:0048066)2.40556301
140positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.39947379
141parturition (GO:0007567)2.38370303
142regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.38269898
143positive regulation of gastrulation (GO:2000543)2.37381703
144embryonic epithelial tube formation (GO:0001838)2.37366265
145regulation of telomere maintenance (GO:0032204)2.37017636
146cell differentiation involved in kidney development (GO:0061005)2.36912592
147neuron maturation (GO:0042551)2.36344845
148positive regulation of oligodendrocyte differentiation (GO:0048714)2.35716028
149cilium assembly (GO:0042384)2.34734847
150glutamate receptor signaling pathway (GO:0007215)2.34682084
151negative regulation of axon guidance (GO:1902668)2.34603264
152detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.34387982
153regulation of platelet aggregation (GO:0090330)2.34215688
154ovulation cycle (GO:0042698)2.34202507
155cyclic nucleotide catabolic process (GO:0009214)2.34133947
156detection of molecule of bacterial origin (GO:0032490)2.34122401
157histone H3-K4 trimethylation (GO:0080182)2.33839446
158spinal cord motor neuron differentiation (GO:0021522)2.32958159
159female gonad development (GO:0008585)2.31960275
160protein localization to synapse (GO:0035418)2.31218045
161photoreceptor cell maintenance (GO:0045494)2.30820221
162reflex (GO:0060004)2.30058371
163G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.28560970
164neuron recognition (GO:0008038)2.28132207
165DNA integration (GO:0015074)2.26758586
166pyrimidine dimer repair (GO:0006290)2.26541270
167G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.25645057
168auditory receptor cell stereocilium organization (GO:0060088)2.24810683
169regulation of interleukin-1 beta secretion (GO:0050706)2.24484963
170negative regulation of synaptic transmission, GABAergic (GO:0032229)2.23698133
171interferon-gamma production (GO:0032609)2.23198796
172regulation of feeding behavior (GO:0060259)2.23101323
173protein heterotetramerization (GO:0051290)2.22931429
174positive regulation of heat generation (GO:0031652)2.21699276
175forebrain neuron differentiation (GO:0021879)2.21227067
176regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.21103408
177cAMP catabolic process (GO:0006198)2.20713359
178cellular response to interleukin-15 (GO:0071350)2.19356409
179response to peptidoglycan (GO:0032494)2.18546337
180nonmotile primary cilium assembly (GO:0035058)2.17555621
181microglial cell activation (GO:0001774)2.17546747
182cilium organization (GO:0044782)2.15700899
183central nervous system projection neuron axonogenesis (GO:0021952)2.14422180
184dendritic spine morphogenesis (GO:0060997)2.14295006
185positive regulation of mast cell activation (GO:0033005)2.14112706

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.67872717
2GBX2_23144817_ChIP-Seq_PC3_Human3.62653551
3ZNF274_21170338_ChIP-Seq_K562_Hela3.17321928
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78435803
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.76439113
6* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.62472881
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57546676
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.53176838
9* CBX2_27304074_Chip-Seq_ESCs_Mouse2.45520625
10IGF1R_20145208_ChIP-Seq_DFB_Human2.38541418
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37786031
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.37499828
13* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24520484
14* EZH2_27304074_Chip-Seq_ESCs_Mouse2.17979080
15SUZ12_27294783_Chip-Seq_NPCs_Mouse2.17853771
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17269413
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13857503
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.12253212
19RNF2_27304074_Chip-Seq_NSC_Mouse2.11486386
20PCGF2_27294783_Chip-Seq_NPCs_Mouse2.03169693
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.01620070
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.99454873
23* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98805682
24TAF15_26573619_Chip-Seq_HEK293_Human1.93402229
25* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.93041963
26P300_19829295_ChIP-Seq_ESCs_Human1.87044736
27NANOG_18555785_Chip-Seq_ESCs_Mouse1.82623445
28EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.81509299
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.80502610
30* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78872684
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.78302841
32SUZ12_18555785_Chip-Seq_ESCs_Mouse1.77422449
33* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75497605
34P53_22387025_ChIP-Seq_ESCs_Mouse1.75450620
35E2F1_18555785_Chip-Seq_ESCs_Mouse1.75326437
36* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74765407
37STAT3_18555785_Chip-Seq_ESCs_Mouse1.74411175
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.74086712
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72114763
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71882217
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69036653
42EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.66789289
43NMYC_18555785_Chip-Seq_ESCs_Mouse1.65933169
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.65875842
45CMYC_18555785_Chip-Seq_ESCs_Mouse1.65424854
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65124558
47FUS_26573619_Chip-Seq_HEK293_Human1.64410946
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63865585
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61160091
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59119166
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58791180
52* RNF2_27304074_Chip-Seq_ESCs_Mouse1.58126923
53* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56756407
54ER_23166858_ChIP-Seq_MCF-7_Human1.56099383
55* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54974594
56* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54974594
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.54694179
58SOX2_18555785_Chip-Seq_ESCs_Mouse1.54606310
59P300_18555785_Chip-Seq_ESCs_Mouse1.54540056
60* EZH2_27294783_Chip-Seq_ESCs_Mouse1.54445210
61RUNX1_27457419_Chip-Seq_LIVER_Mouse1.53603942
62BCAT_22108803_ChIP-Seq_LS180_Human1.51445026
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50602070
64* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49787053
65HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49525428
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.48134345
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46798029
68EWS_26573619_Chip-Seq_HEK293_Human1.45343707
69SMAD4_21799915_ChIP-Seq_A2780_Human1.45233814
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.44065063
71ZFX_18555785_Chip-Seq_ESCs_Mouse1.43123065
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43032327
73* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42543307
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.42267147
75AR_25329375_ChIP-Seq_VCAP_Human1.42177636
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41595788
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.41163579
78KLF4_18555785_Chip-Seq_ESCs_Mouse1.40454886
79REST_21632747_ChIP-Seq_MESCs_Mouse1.40396327
80VDR_22108803_ChIP-Seq_LS180_Human1.39821431
81PU1_27457419_Chip-Seq_LIVER_Mouse1.38875940
82ESRRB_18555785_Chip-Seq_ESCs_Mouse1.38526367
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.37346366
84AR_21572438_ChIP-Seq_LNCaP_Human1.36593846
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36512480
86SMAD1_18555785_Chip-Seq_ESCs_Mouse1.34782997
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33553788
88NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33507702
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33210015
90ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33117292
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32823594
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32748213
93CTCF_18555785_Chip-Seq_ESCs_Mouse1.32736995
94CBP_20019798_ChIP-Seq_JUKART_Human1.31494008
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31494008
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31123191
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31123191
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31016673
99* TAL1_26923725_Chip-Seq_HPCs_Mouse1.30043483
100TP53_22573176_ChIP-Seq_HFKS_Human1.27036402
101* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26434295
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25628934
103CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.24861382
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22077222
105DROSHA_22980978_ChIP-Seq_HELA_Human1.19412140
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19002796
107* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18793312
108CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17904428
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17464099
110* CRX_20693478_ChIP-Seq_RETINA_Mouse1.16970848
111KDM2B_26808549_Chip-Seq_REH_Human1.15971149
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15693951
113* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15504239
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15478033
115ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14643937
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13069313
117NCOR_22424771_ChIP-Seq_293T_Human1.12583604
118TCF4_22108803_ChIP-Seq_LS180_Human1.11893220
119* IRF1_19129219_ChIP-ChIP_H3396_Human1.11234135
120STAT3_23295773_ChIP-Seq_U87_Human1.11021761
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.10670995
122FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10670995
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10639706
124RUNX2_22187159_ChIP-Seq_PCA_Human1.10433062
125* TCF4_23295773_ChIP-Seq_U87_Human1.10343644
126GATA3_21878914_ChIP-Seq_MCF-7_Human1.09874526
127SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09226472
128NANOG_19829295_ChIP-Seq_ESCs_Human1.05723468
129SOX2_19829295_ChIP-Seq_ESCs_Human1.05723468
130CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05550677
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05423347
132P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05373618
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04941798
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04717722
135SMAD4_21741376_ChIP-Seq_EPCs_Human1.03964093
136MYC_18940864_ChIP-ChIP_HL60_Human1.02110680
137* RING1B_27294783_Chip-Seq_ESCs_Mouse0.99294455
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.98937240
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.98838933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.23016348
2MP0001188_hyperpigmentation3.63544102
3MP0000566_synostosis3.47443377
4MP0002102_abnormal_ear_morphology3.05399424
5MP0003880_abnormal_central_pattern3.01458754
6MP0005645_abnormal_hypothalamus_physiol2.89556620
7MP0002638_abnormal_pupillary_reflex2.73296476
8MP0005646_abnormal_pituitary_gland2.63326777
9MP0003283_abnormal_digestive_organ2.52941188
10MP0002653_abnormal_ependyma_morphology2.26806258
11MP0003787_abnormal_imprinting2.16627709
12MP0003136_yellow_coat_color2.10751133
13MP0005171_absent_coat_pigmentation2.07692042
14MP0002735_abnormal_chemical_nociception2.05048013
15MP0002837_dystrophic_cardiac_calcinosis2.00506028
16MP0008877_abnormal_DNA_methylation1.99823349
17MP0006276_abnormal_autonomic_nervous1.98744376
18MP0001486_abnormal_startle_reflex1.96383029
19MP0003646_muscle_fatigue1.93124891
20MP0004742_abnormal_vestibular_system1.92504949
21MP0002163_abnormal_gland_morphology1.90744562
22MP0005423_abnormal_somatic_nervous1.84687959
23MP0001986_abnormal_taste_sensitivity1.84680834
24MP0004145_abnormal_muscle_electrophysio1.79808248
25MP0009697_abnormal_copulation1.78511900
26MP0005409_darkened_coat_color1.75781771
27MP0000569_abnormal_digit_pigmentation1.72246574
28MP0002277_abnormal_respiratory_mucosa1.71823206
29MP0005379_endocrine/exocrine_gland_phen1.65152379
30MP0003121_genomic_imprinting1.62841249
31MP0005257_abnormal_intraocular_pressure1.60179556
32MP0008789_abnormal_olfactory_epithelium1.59758047
33MP0010386_abnormal_urinary_bladder1.59476452
34MP0008872_abnormal_physiological_respon1.59095150
35MP0004885_abnormal_endolymph1.57552547
36MP0004133_heterotaxia1.54993812
37MP0003122_maternal_imprinting1.54260140
38MP0001968_abnormal_touch/_nociception1.54005441
39MP0000015_abnormal_ear_pigmentation1.51343969
40MP0002572_abnormal_emotion/affect_behav1.50199749
41MP0008995_early_reproductive_senescence1.49613324
42MP0005084_abnormal_gallbladder_morpholo1.49162795
43MP0001529_abnormal_vocalization1.48742400
44MP0000778_abnormal_nervous_system1.48085716
45MP0001502_abnormal_circadian_rhythm1.45429667
46MP0002736_abnormal_nociception_after1.45218494
47MP0009745_abnormal_behavioral_response1.45134343
48MP0002938_white_spotting1.44984476
49MP0000955_abnormal_spinal_cord1.44045783
50MP0002132_abnormal_respiratory_system1.42975983
51MP0005551_abnormal_eye_electrophysiolog1.42305555
52MP0005394_taste/olfaction_phenotype1.41132438
53MP0005499_abnormal_olfactory_system1.41132438
54MP0001984_abnormal_olfaction1.39083511
55MP0001346_abnormal_lacrimal_gland1.38022198
56MP0002557_abnormal_social/conspecific_i1.37750902
57MP0001905_abnormal_dopamine_level1.33297786
58MP0002909_abnormal_adrenal_gland1.31802121
59MP0000026_abnormal_inner_ear1.31182740
60MP0002148_abnormal_hypersensitivity_rea1.30766092
61MP0002160_abnormal_reproductive_system1.30525507
62MP0003195_calcinosis1.28940398
63MP0002734_abnormal_mechanical_nocicepti1.28155562
64MP0001963_abnormal_hearing_physiology1.26785828
65MP0009046_muscle_twitch1.25798960
66MP0003119_abnormal_digestive_system1.24686698
67MP0002067_abnormal_sensory_capabilities1.24219875
68MP0000631_abnormal_neuroendocrine_gland1.20779975
69MP0000427_abnormal_hair_cycle1.19698236
70MP0008004_abnormal_stomach_pH1.18301529
71MP0003123_paternal_imprinting1.18203169
72MP0005253_abnormal_eye_physiology1.16895844
73MP0001485_abnormal_pinna_reflex1.16807268
74MP0002063_abnormal_learning/memory/cond1.15760455
75MP0002138_abnormal_hepatobiliary_system1.15692577
76MP0002272_abnormal_nervous_system1.15159525
77MP0003635_abnormal_synaptic_transmissio1.14889083
78MP0009785_altered_susceptibility_to1.14482971
79MP0005389_reproductive_system_phenotype1.14088014
80MP0004142_abnormal_muscle_tone1.11653817
81MP0005174_abnormal_tail_pigmentation1.11386517
82MP0003938_abnormal_ear_development1.11339000
83MP0001348_abnormal_lacrimal_gland1.11222971
84MP0003878_abnormal_ear_physiology1.11220961
85MP0005377_hearing/vestibular/ear_phenot1.11220961
86MP0000372_irregular_coat_pigmentation1.09928272
87MP0005671_abnormal_response_to1.09157734
88MP0002751_abnormal_autonomic_nervous1.09139113
89MP0001835_abnormal_antigen_presentation1.08492574
90MP0002184_abnormal_innervation1.06500251
91MP0008058_abnormal_DNA_repair1.05322563
92MP0002876_abnormal_thyroid_physiology1.04439077
93MP0003890_abnormal_embryonic-extraembry1.03020456
94MP0004381_abnormal_hair_follicle1.01930646
95MP0001501_abnormal_sleep_pattern1.00669226
96MP0002064_seizures0.99929533
97MP0002928_abnormal_bile_duct0.99641245
98MP0003011_delayed_dark_adaptation0.98317576
99MP0008875_abnormal_xenobiotic_pharmacok0.95894286
100MP0000049_abnormal_middle_ear0.95880382
101MP0001440_abnormal_grooming_behavior0.94390294
102MP0003941_abnormal_skin_development0.94361911
103MP0009379_abnormal_foot_pigmentation0.93624701
104MP0002234_abnormal_pharynx_morphology0.92983556
105MP0002752_abnormal_somatic_nervous0.92907675
106MP0004270_analgesia0.92070624
107MP0003937_abnormal_limbs/digits/tail_de0.91386716
108MP0002822_catalepsy0.89805359
109MP0008260_abnormal_autophagy0.89659244
110MP0004043_abnormal_pH_regulation0.89650095
111MP0006072_abnormal_retinal_apoptosis0.88569357
112MP0004859_abnormal_synaptic_plasticity0.88168398
113MP0001970_abnormal_pain_threshold0.86708883
114MP0000383_abnormal_hair_follicle0.85135525
115MP0001293_anophthalmia0.85004801
116MP0001919_abnormal_reproductive_system0.84776725
117MP0002095_abnormal_skin_pigmentation0.83892864
118MP0001664_abnormal_digestion0.81636325
119MP0002229_neurodegeneration0.80969279
120MP0003950_abnormal_plasma_membrane0.80331901
121MP0000678_abnormal_parathyroid_gland0.80285629
122MP0004134_abnormal_chest_morphology0.79785823
123MP0004782_abnormal_surfactant_physiolog0.79491902
124MP0004924_abnormal_behavior0.78725288
125MP0005386_behavior/neurological_phenoty0.78725288
126MP0005451_abnormal_body_composition0.77666902
127MP0001944_abnormal_pancreas_morphology0.76963187
128MP0008057_abnormal_DNA_replication0.76936764
129MP0002733_abnormal_thermal_nociception0.76556897
130MP0005195_abnormal_posterior_eye0.75701092
131MP0002882_abnormal_neuron_morphology0.74188663
132MP0005248_abnormal_Harderian_gland0.71870248
133MP0001177_atelectasis0.71104029
134MP0006082_CNS_inflammation0.69920872
135MP0003724_increased_susceptibility_to0.69068082

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.78652605
2Molar tooth sign on MRI (HP:0002419)4.20162893
3Abnormality of midbrain morphology (HP:0002418)4.20162893
4Chromsome breakage (HP:0040012)4.03649666
5Pancreatic fibrosis (HP:0100732)4.02446596
6Abnormal pancreas size (HP:0012094)3.66590391
7Duplicated collecting system (HP:0000081)3.56693321
8Progressive cerebellar ataxia (HP:0002073)3.52089119
9Abnormality of the renal collecting system (HP:0004742)3.42729233
10Febrile seizures (HP:0002373)3.39679023
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.24192286
12Absent/shortened dynein arms (HP:0200106)3.24192286
13Abnormal rod and cone electroretinograms (HP:0008323)3.16028553
14Genetic anticipation (HP:0003743)3.15606672
15Septo-optic dysplasia (HP:0100842)3.04406599
16Hypoplasia of the fovea (HP:0007750)3.03489934
17Aplasia/Hypoplasia of the fovea (HP:0008060)3.03489934
18Absent rod-and cone-mediated responses on ERG (HP:0007688)3.01055913
19Aplasia cutis congenita (HP:0001057)2.98852072
20Cystic liver disease (HP:0006706)2.83626452
21Abnormal hair whorl (HP:0010721)2.82502688
22Tubular atrophy (HP:0000092)2.80788217
23White forelock (HP:0002211)2.73392342
24Congenital sensorineural hearing impairment (HP:0008527)2.73129932
25Decreased central vision (HP:0007663)2.73013232
26Abnormality of the renal cortex (HP:0011035)2.72514136
27Hypothermia (HP:0002045)2.72169577
28Patchy hypopigmentation of hair (HP:0011365)2.68663555
29Optic nerve hypoplasia (HP:0000609)2.66724185
30Medial flaring of the eyebrow (HP:0010747)2.61736901
31Focal motor seizures (HP:0011153)2.61266313
32Sclerocornea (HP:0000647)2.61214933
33Type II lissencephaly (HP:0007260)2.56100542
34Abnormality of DNA repair (HP:0003254)2.55300741
35Adrenal hypoplasia (HP:0000835)2.51174425
36Abolished electroretinogram (ERG) (HP:0000550)2.50414677
37Abnormality of the fovea (HP:0000493)2.48395890
38Gaze-evoked nystagmus (HP:0000640)2.47853667
39Parakeratosis (HP:0001036)2.46014757
40Osteomalacia (HP:0002749)2.45906949
41Duplication of thumb phalanx (HP:0009942)2.44716746
42Abnormal drinking behavior (HP:0030082)2.43879537
43Polydipsia (HP:0001959)2.43879537
44Fair hair (HP:0002286)2.42630627
45Ectopic kidney (HP:0000086)2.40697517
46Abnormality of incisor morphology (HP:0011063)2.39716240
47Protruding tongue (HP:0010808)2.37030222
48Attenuation of retinal blood vessels (HP:0007843)2.36558502
49Congenital stationary night blindness (HP:0007642)2.35593616
50Abnormal ciliary motility (HP:0012262)2.33989580
51Agitation (HP:0000713)2.33822189
52Abnormal respiratory motile cilium morphology (HP:0005938)2.33758206
53Abnormal respiratory epithelium morphology (HP:0012253)2.33758206
54Abnormality of the preputium (HP:0100587)2.31383812
55Broad-based gait (HP:0002136)2.27203965
56Conical tooth (HP:0000698)2.25838804
57Bony spicule pigmentary retinopathy (HP:0007737)2.25345406
58Prostate neoplasm (HP:0100787)2.23941668
59Gait imbalance (HP:0002141)2.23393844
60Lissencephaly (HP:0001339)2.21444248
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.20864001
62Nephrogenic diabetes insipidus (HP:0009806)2.20773930
63Absent septum pellucidum (HP:0001331)2.19944508
64Anencephaly (HP:0002323)2.17836587
65Tubulointerstitial nephritis (HP:0001970)2.16952132
66Pachygyria (HP:0001302)2.12886739
67Anomalous pulmonary venous return (HP:0010772)2.10795453
68Clubbing of toes (HP:0100760)2.10567945
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10480195
70Chorioretinal atrophy (HP:0000533)2.09935533
71Epileptic encephalopathy (HP:0200134)2.08799065
72Aplasia/Hypoplasia of the spleen (HP:0010451)2.05749917
73Genital tract atresia (HP:0001827)2.05635235
74Shawl scrotum (HP:0000049)2.05535314
75Generalized hypopigmentation of hair (HP:0011358)2.04537858
76Morphological abnormality of the middle ear (HP:0008609)2.03538988
77Congenital hepatic fibrosis (HP:0002612)2.03296712
78Esotropia (HP:0000565)2.02952730
79Congenital primary aphakia (HP:0007707)2.02667839
80Nasolacrimal duct obstruction (HP:0000579)2.02197087
81Abnormal biliary tract physiology (HP:0012439)2.02012634
82Bile duct proliferation (HP:0001408)2.02012634
83Vaginal atresia (HP:0000148)2.01593781
84Aplasia/Hypoplasia of the tongue (HP:0010295)2.00932326
85Abnormality of the nasal septum (HP:0000419)2.00725716
86Furrowed tongue (HP:0000221)2.00681921
87Abnormality of the septum pellucidum (HP:0007375)1.99418177
88Aplasia/hypoplasia of the uterus (HP:0008684)1.99288113
89Focal seizures (HP:0007359)1.98915062
90Obstructive lung disease (HP:0006536)1.97762146
91Chronic obstructive pulmonary disease (HP:0006510)1.97762146
92Neoplasm of the adrenal cortex (HP:0100641)1.97189334
93Meckel diverticulum (HP:0002245)1.97125269
94Rib fusion (HP:0000902)1.96163390
95Abnormality of the ileum (HP:0001549)1.95628942
96True hermaphroditism (HP:0010459)1.95495635
97Chronic hepatic failure (HP:0100626)1.95210123
98Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95033034
99Polyuria (HP:0000103)1.94860288
100Recurrent cutaneous fungal infections (HP:0011370)1.92785383
101Chronic mucocutaneous candidiasis (HP:0002728)1.92785383
102Limb dystonia (HP:0002451)1.92396480
103Asplenia (HP:0001746)1.91505611
104Hypoplasia of the uterus (HP:0000013)1.91125490
105Optic neuritis (HP:0100653)1.90992350
106Retrobulbar optic neuritis (HP:0100654)1.90992350
107Decreased circulating renin level (HP:0003351)1.90801607
108Drooling (HP:0002307)1.90628987
109Abnormality of macular pigmentation (HP:0008002)1.90609908
110Atelectasis (HP:0100750)1.90369699
111Patellar aplasia (HP:0006443)1.90148774
112Increased corneal curvature (HP:0100692)1.89971852
113Keratoconus (HP:0000563)1.89971852
114Aplasia/Hypoplasia of the lens (HP:0008063)1.88871472
115Poor coordination (HP:0002370)1.88038656
116Aplasia/Hypoplasia of the patella (HP:0006498)1.87787257
117Nephronophthisis (HP:0000090)1.87780180
118Conjugated hyperbilirubinemia (HP:0002908)1.86408245
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85890991
120Abnormality of alanine metabolism (HP:0010916)1.85890991
121Hyperalaninemia (HP:0003348)1.85890991
122Renal Fanconi syndrome (HP:0001994)1.85819013
123Myokymia (HP:0002411)1.85766931
124Pancreatic cysts (HP:0001737)1.85259682
125Hemiparesis (HP:0001269)1.85095864
126Cheilitis (HP:0100825)1.84628346
127Abnormality of the labia minora (HP:0012880)1.84596712
128Concave nail (HP:0001598)1.84159023
129Pendular nystagmus (HP:0012043)1.82453165
130Exotropia (HP:0000577)1.81872441
131Abnormality of the pulmonary veins (HP:0011718)1.81236268
132Postaxial hand polydactyly (HP:0001162)1.81013779
133Abnormality of the lacrimal duct (HP:0011481)1.80905081
134Retinal dysplasia (HP:0007973)1.78271298
135Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.77959716
136Oligodactyly (hands) (HP:0001180)1.76170485
137Abnormality of the axillary hair (HP:0100134)1.75817271
138Abnormality of secondary sexual hair (HP:0009888)1.75817271
139Abnormality of the renal medulla (HP:0100957)1.75798440
140Tetany (HP:0001281)1.74522072
141Abnormality of the nasolacrimal system (HP:0000614)1.73213748
142Astigmatism (HP:0000483)1.73202664
143Specific learning disability (HP:0001328)1.73155461
144Absent speech (HP:0001344)1.73013404
145Lip pit (HP:0100267)1.72495733
146Preaxial hand polydactyly (HP:0001177)1.72305184
147Postaxial foot polydactyly (HP:0001830)1.70571082
148Aplasia/Hypoplasia of the macula (HP:0008059)1.68721783
149Inability to walk (HP:0002540)1.68684542
150Hyperventilation (HP:0002883)1.68377686
151Severe visual impairment (HP:0001141)1.68114065
152Narrow forehead (HP:0000341)1.67261106
153Aganglionic megacolon (HP:0002251)1.67168280
154Retinitis pigmentosa (HP:0000510)1.67166797
155Abnormal respiratory motile cilium physiology (HP:0012261)1.66765978
156Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.66728609
157Dialeptic seizures (HP:0011146)1.66660302
158Thyroid-stimulating hormone excess (HP:0002925)1.66579283
159Excessive salivation (HP:0003781)1.66245608
160Anophthalmia (HP:0000528)1.66013981
161Male pseudohermaphroditism (HP:0000037)1.65653731
162Small hand (HP:0200055)1.65539736
163Abnormality of renal resorption (HP:0011038)1.64827009
164Fetal akinesia sequence (HP:0001989)1.64206549
165Cerebellar dysplasia (HP:0007033)1.64187873
166Absent eyebrow (HP:0002223)1.63856145
167Tented upper lip vermilion (HP:0010804)1.62993893
168Reticulocytopenia (HP:0001896)1.62271674
169Xerostomia (HP:0000217)1.61970425
170Cupped ear (HP:0000378)1.61549681
171Increased hepatocellular lipid droplets (HP:0006565)1.61164308
172Recurrent pneumonia (HP:0006532)1.60762464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.46124695
2FRK5.07997554
3TNIK3.25917307
4PRPF4B3.20584450
5PINK12.61851093
6TXK2.53737928
7WNK42.39229935
8SIK32.33577584
9MAPK132.25051525
10STK162.25024438
11BMPR1B2.10614960
12MARK12.07186192
13MAP4K22.01063717
14MAP3K121.97325708
15IRAK41.96318519
16MAP3K141.73304571
17MAP2K71.71405131
18BLK1.64481249
19ADRBK21.59932711
20PASK1.58909592
21EIF2AK21.58866966
22MKNK21.56635776
23IRAK31.54012195
24STK391.51816308
25NTRK31.51210914
26INSRR1.47893931
27YES11.47447120
28ZAK1.45707514
29MINK11.43754488
30PAK31.36060128
31DAPK21.34758438
32GRK11.31719488
33BMPR21.28320584
34SIK21.28290716
35MUSK1.27922788
36TNK21.24878062
37CSNK1G21.23922002
38NTRK21.22326716
39TIE11.19360519
40TAOK21.17859122
41NEK61.14834988
42SRPK11.14643889
43DYRK21.14250959
44PKN11.13266589
45NUAK11.09057910
46STK111.07526563
47TAOK31.07276127
48NME21.04854500
49MKNK11.02623633
50AKT31.00977626
51IRAK20.98419447
52WNK30.97615697
53RIPK40.95699024
54UHMK10.92665049
55EPHA40.91967397
56ERBB30.91956068
57BCR0.90293163
58DYRK30.90015262
59CDK30.88432684
60GRK70.86430863
61STK30.84952821
62CDK80.83764030
63TRIM280.82424584
64SGK20.80683865
65IRAK10.79645144
66NLK0.78660716
67PBK0.78414467
68FLT30.76092274
69PRKCE0.75583752
70TLK10.73413317
71FGFR20.73243844
72NME10.72317220
73PLK40.72227625
74MAP2K40.70443691
75BRD40.69126693
76EPHB20.69097871
77PRKCI0.68769983
78VRK10.68712575
79OXSR10.68420037
80TEC0.67977055
81DYRK1A0.67784146
82MAP2K60.66972708
83FES0.64671662
84PLK20.63714164
85CLK10.63422722
86SGK4940.63195024
87SGK2230.63195024
88CSNK1A10.63043901
89STK38L0.59881187
90CAMK1G0.59281657
91CDK50.59277138
92KIT0.58934677
93CAMK2A0.57430180
94MAP3K90.56895285
95PRKAA10.56712451
96ACVR1B0.56044444
97PRKCQ0.54968869
98PTK2B0.54840619
99CAMK2B0.54150722
100CAMKK20.53990585
101PRKCH0.53703395
102MAPKAPK30.53472579
103CCNB10.53359783
104IKBKE0.52797801
105PRKCZ0.52578787
106GRK50.49978214
107PIK3CG0.48992782
108ERBB20.48751257
109LYN0.48176842
110CDK190.48148359
111FGR0.48137945
112MAPK150.48109726
113CAMK10.47997091
114IKBKB0.47389639
115MAP3K40.45877703
116CSNK1D0.43391487
117JAK30.42944652
118PIK3CA0.42890911
119CSNK1G30.42785956
120SYK0.42420050
121PRKG10.41973644
122CSNK1G10.40232280
123RPS6KA60.39296917
124CSNK1E0.39244889
125CSNK1A1L0.39208955
126MAPK40.38369010
127MARK30.36755417
128BRAF0.36037246
129PHKG10.35131906
130PHKG20.35131906
131MST1R0.35123349
132HIPK20.34565108
133ADRBK10.34292473
134SGK10.33769186
135PRKCA0.33232567
136PNCK0.31545059
137PRKACA0.31100685
138MAPK80.28515462
139CHUK0.28443075
140RPS6KA50.27949131
141NEK20.26828047
142CAMK1D0.26526345
143ATR0.26436813
144WNK10.25928801
145TAF10.25782965
146PRKCG0.24741195
147GSK3B0.24206155
148MAPK90.23324669

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.07303052
2Graft-versus-host disease_Homo sapiens_hsa053322.40408373
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.25792529
4Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.16924942
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15945185
6Fanconi anemia pathway_Homo sapiens_hsa034601.95701639
7Autoimmune thyroid disease_Homo sapiens_hsa053201.94591080
8Taste transduction_Homo sapiens_hsa047421.88211327
9Allograft rejection_Homo sapiens_hsa053301.86818440
10Linoleic acid metabolism_Homo sapiens_hsa005911.86682452
11Rheumatoid arthritis_Homo sapiens_hsa053231.83027011
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78361271
13Phototransduction_Homo sapiens_hsa047441.77640606
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.71183243
15Oxidative phosphorylation_Homo sapiens_hsa001901.66172586
16Morphine addiction_Homo sapiens_hsa050321.64253003
17Nitrogen metabolism_Homo sapiens_hsa009101.64195573
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.62298133
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61327554
20Butanoate metabolism_Homo sapiens_hsa006501.60890158
21Serotonergic synapse_Homo sapiens_hsa047261.53907936
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53885787
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52912185
24Basal transcription factors_Homo sapiens_hsa030221.47569326
25RNA polymerase_Homo sapiens_hsa030201.46108203
26Tryptophan metabolism_Homo sapiens_hsa003801.45949632
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.45947081
28Collecting duct acid secretion_Homo sapiens_hsa049661.39919041
29Asthma_Homo sapiens_hsa053101.36945042
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35250882
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34652206
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30439574
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29719731
34Selenocompound metabolism_Homo sapiens_hsa004501.25635556
35Sphingolipid metabolism_Homo sapiens_hsa006001.24709748
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19545856
37Type I diabetes mellitus_Homo sapiens_hsa049401.18822176
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18760016
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.16052791
40Steroid biosynthesis_Homo sapiens_hsa001001.15632817
41Chemical carcinogenesis_Homo sapiens_hsa052041.14671053
42Hematopoietic cell lineage_Homo sapiens_hsa046401.14261733
43Glutamatergic synapse_Homo sapiens_hsa047241.14167354
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13566615
45Retinol metabolism_Homo sapiens_hsa008301.13168914
46Homologous recombination_Homo sapiens_hsa034401.12655362
47Caffeine metabolism_Homo sapiens_hsa002321.12105098
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11007148
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10819148
50Ether lipid metabolism_Homo sapiens_hsa005651.10487355
51Alzheimers disease_Homo sapiens_hsa050101.10224251
52Parkinsons disease_Homo sapiens_hsa050121.09848980
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05906857
54Primary immunodeficiency_Homo sapiens_hsa053401.04356928
55Axon guidance_Homo sapiens_hsa043601.03258412
56Olfactory transduction_Homo sapiens_hsa047401.02717998
57Synaptic vesicle cycle_Homo sapiens_hsa047211.02498972
58Phagosome_Homo sapiens_hsa041451.02451181
59Circadian entrainment_Homo sapiens_hsa047131.00967454
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00860070
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98959974
62Huntingtons disease_Homo sapiens_hsa050160.97922629
63GABAergic synapse_Homo sapiens_hsa047270.97124021
64Arachidonic acid metabolism_Homo sapiens_hsa005900.96408704
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95539995
66Measles_Homo sapiens_hsa051620.95230669
67African trypanosomiasis_Homo sapiens_hsa051430.94854593
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94674392
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94402736
70Basal cell carcinoma_Homo sapiens_hsa052170.94379429
71Hedgehog signaling pathway_Homo sapiens_hsa043400.90907863
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88962889
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.87669556
74Pyrimidine metabolism_Homo sapiens_hsa002400.87665984
75Dorso-ventral axis formation_Homo sapiens_hsa043200.84839745
76Protein export_Homo sapiens_hsa030600.84711616
77Calcium signaling pathway_Homo sapiens_hsa040200.83288870
78ABC transporters_Homo sapiens_hsa020100.82839112
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81868031
80Glycerolipid metabolism_Homo sapiens_hsa005610.81848996
81Peroxisome_Homo sapiens_hsa041460.80105832
82Sulfur metabolism_Homo sapiens_hsa009200.78729810
83Purine metabolism_Homo sapiens_hsa002300.77298053
84Leishmaniasis_Homo sapiens_hsa051400.74954546
85Malaria_Homo sapiens_hsa051440.73549171
86Cocaine addiction_Homo sapiens_hsa050300.72073341
87Gastric acid secretion_Homo sapiens_hsa049710.71497798
88Regulation of autophagy_Homo sapiens_hsa041400.71083815
89Non-homologous end-joining_Homo sapiens_hsa034500.69214890
90Propanoate metabolism_Homo sapiens_hsa006400.68268406
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67812390
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67476892
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67168679
94Oxytocin signaling pathway_Homo sapiens_hsa049210.66825239
95Ovarian steroidogenesis_Homo sapiens_hsa049130.65897820
96Histidine metabolism_Homo sapiens_hsa003400.65228855
97Nucleotide excision repair_Homo sapiens_hsa034200.64822966
98Chemokine signaling pathway_Homo sapiens_hsa040620.63848373
99Type II diabetes mellitus_Homo sapiens_hsa049300.62539800
100Cholinergic synapse_Homo sapiens_hsa047250.62381970
101One carbon pool by folate_Homo sapiens_hsa006700.62117235
102Fat digestion and absorption_Homo sapiens_hsa049750.61161406
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60032423
104beta-Alanine metabolism_Homo sapiens_hsa004100.59239257
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58490109
106Long-term depression_Homo sapiens_hsa047300.58185233
107Herpes simplex infection_Homo sapiens_hsa051680.58046463
108Vibrio cholerae infection_Homo sapiens_hsa051100.56445243
109Hippo signaling pathway_Homo sapiens_hsa043900.56215309
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55151552
111Insulin secretion_Homo sapiens_hsa049110.55096863
112Influenza A_Homo sapiens_hsa051640.53985115
113Cardiac muscle contraction_Homo sapiens_hsa042600.53793882
114Salivary secretion_Homo sapiens_hsa049700.52147655
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51439006
116Circadian rhythm_Homo sapiens_hsa047100.51007120
117cAMP signaling pathway_Homo sapiens_hsa040240.49702636
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48253992
119Tuberculosis_Homo sapiens_hsa051520.47665116
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46928314
121Pertussis_Homo sapiens_hsa051330.46804596
122Ras signaling pathway_Homo sapiens_hsa040140.46802543
123Metabolic pathways_Homo sapiens_hsa011000.46164463
124Mineral absorption_Homo sapiens_hsa049780.45519468
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44155192
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.44132848
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.43900893
128Salmonella infection_Homo sapiens_hsa051320.43594070
129Proteasome_Homo sapiens_hsa030500.43247987
130Amphetamine addiction_Homo sapiens_hsa050310.43227465
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41334423
132Dopaminergic synapse_Homo sapiens_hsa047280.40538564
133RNA degradation_Homo sapiens_hsa030180.40476401
134Fatty acid degradation_Homo sapiens_hsa000710.40406008
135MAPK signaling pathway_Homo sapiens_hsa040100.40042276
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39659327
137Wnt signaling pathway_Homo sapiens_hsa043100.38992908
138Maturity onset diabetes of the young_Homo sapiens_hsa049500.38366001
139TNF signaling pathway_Homo sapiens_hsa046680.37809332
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37346699
141Osteoclast differentiation_Homo sapiens_hsa043800.36363588
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.36075371
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35722676
144Renin secretion_Homo sapiens_hsa049240.35448470
145Melanogenesis_Homo sapiens_hsa049160.31026909
146Ribosome_Homo sapiens_hsa030100.30910455

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