OOEP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of retinoic acid receptor signaling pathway (GO:0048385)7.66420035
2oocyte development (GO:0048599)6.62019014
3piRNA metabolic process (GO:0034587)6.58350117
4retinal cone cell development (GO:0046549)6.29091887
5mitotic chromosome condensation (GO:0007076)5.82638539
6positive regulation of histone H3-K4 methylation (GO:0051571)5.74883934
7mitotic metaphase plate congression (GO:0007080)5.69874479
8regulation of female gonad development (GO:2000194)5.61048840
9glycine transport (GO:0015816)5.56090319
10female gamete generation (GO:0007292)5.52319720
11regulation of cell maturation (GO:1903429)5.44372687
12regulation of steroid hormone secretion (GO:2000831)5.23124741
13mitotic sister chromatid segregation (GO:0000070)5.22754998
14establishment of chromosome localization (GO:0051303)5.12954829
15synapsis (GO:0007129)5.11875226
16metaphase plate congression (GO:0051310)5.10009991
17kinetochore organization (GO:0051383)5.00944468
18DNA methylation involved in gamete generation (GO:0043046)4.98154631
19histone H2A monoubiquitination (GO:0035518)4.88858906
20positive regulation of gastrulation (GO:2000543)4.86649225
21protein kinase C signaling (GO:0070528)4.85788546
22male meiosis I (GO:0007141)4.84404687
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.77267772
24meiotic chromosome segregation (GO:0045132)4.73803908
25regulation of acrosome reaction (GO:0060046)4.72329633
26attachment of spindle microtubules to kinetochore (GO:0008608)4.62738082
27kinetochore assembly (GO:0051382)4.58893036
28meiotic cell cycle (GO:0051321)4.58666904
29centriole replication (GO:0007099)4.56035788
30primitive streak formation (GO:0090009)4.53404678
31DNA replication checkpoint (GO:0000076)4.47561543
32protein K6-linked ubiquitination (GO:0085020)4.46943527
33oogenesis (GO:0048477)4.44967591
34regulation of exit from mitosis (GO:0007096)4.41875999
35protein localization to kinetochore (GO:0034501)4.40162078
36positive regulation of humoral immune response (GO:0002922)4.38413489
37chromosome organization involved in meiosis (GO:0070192)4.37959918
38regulation of sister chromatid cohesion (GO:0007063)4.36823322
39sister chromatid segregation (GO:0000819)4.24247484
40female gonad development (GO:0008585)4.23297396
41reproduction (GO:0000003)4.17319542
42notochord development (GO:0030903)4.16470625
43protein localization to chromosome, centromeric region (GO:0071459)4.16429338
44negative regulation of meiosis (GO:0045835)4.15445437
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.09902986
46positive regulation of mitotic sister chromatid separation (GO:1901970)4.09902986
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.09902986
48base-excision repair, AP site formation (GO:0006285)4.08836839
49DNA methylation (GO:0006306)4.07362330
50DNA alkylation (GO:0006305)4.07362330
51CENP-A containing nucleosome assembly (GO:0034080)4.06724461
52chromatin remodeling at centromere (GO:0031055)4.06568477
53meiotic nuclear division (GO:0007126)4.03610266
54synaptonemal complex organization (GO:0070193)4.03085704
55meiosis I (GO:0007127)4.02923445
56regulation of double-strand break repair via homologous recombination (GO:0010569)4.01764371
57regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.01046495
58regulation of meiosis (GO:0040020)3.96959867
59histone H2A ubiquitination (GO:0033522)3.94058908
60L-amino acid import (GO:0043092)3.88510258
61regulation of DNA methylation (GO:0044030)3.86928921
62positive regulation of chromosome segregation (GO:0051984)3.83925046
63negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.82408787
64intestinal epithelial cell development (GO:0060576)3.81211234
65regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.78967604
66regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.77892875
67mitotic nuclear envelope disassembly (GO:0007077)3.77100711
68negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.76604155
69pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.76230217
70spindle checkpoint (GO:0031577)3.76003094
71meiotic cell cycle process (GO:1903046)3.75981430
72chromosome segregation (GO:0007059)3.71732402
73positive regulation of uterine smooth muscle contraction (GO:0070474)3.70641190
74positive regulation of reproductive process (GO:2000243)3.68475085
75DNA replication-dependent nucleosome organization (GO:0034723)3.66530238
76DNA replication-dependent nucleosome assembly (GO:0006335)3.66530238
77positive regulation of histone methylation (GO:0031062)3.65303279
78regulation of meiosis I (GO:0060631)3.64486228
79labyrinthine layer development (GO:0060711)3.64126717
80DNA replication-independent nucleosome organization (GO:0034724)3.62029258
81DNA replication-independent nucleosome assembly (GO:0006336)3.62029258
82negative regulation of chromosome segregation (GO:0051985)3.62010099
83regulation of mitotic metaphase/anaphase transition (GO:0030071)3.59840386
84nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.59547480
85DNA damage induced protein phosphorylation (GO:0006975)3.58974092
86histone exchange (GO:0043486)3.56786673
87negative regulation of histone methylation (GO:0031061)3.56532835
88translesion synthesis (GO:0019985)3.55895404
89binding of sperm to zona pellucida (GO:0007339)3.55142676
90negative regulation of sister chromatid segregation (GO:0033046)3.53042164
91negative regulation of mitotic sister chromatid separation (GO:2000816)3.53042164
92negative regulation of mitotic sister chromatid segregation (GO:0033048)3.53042164
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.53042164
94regulation of mitotic sister chromatid separation (GO:0010965)3.51934730
95regulation of mitotic sister chromatid segregation (GO:0033047)3.51934730
96regulation of sister chromatid segregation (GO:0033045)3.51934730
97multicellular organism reproduction (GO:0032504)3.50538780
98male meiosis (GO:0007140)3.50415243
99membrane disassembly (GO:0030397)3.49589393
100nuclear envelope disassembly (GO:0051081)3.49589393
101regulation of chromosome segregation (GO:0051983)3.49579910
102spindle assembly checkpoint (GO:0071173)3.49518390
103mitotic spindle assembly checkpoint (GO:0007094)3.48851931
104mitotic spindle checkpoint (GO:0071174)3.46981342
105somite rostral/caudal axis specification (GO:0032525)3.46570594
106regulation of spindle organization (GO:0090224)3.46366418
107regulation of mitotic spindle organization (GO:0060236)3.43317120
108negative regulation of cell division (GO:0051782)3.42745136
109protein localization to chromosome (GO:0034502)3.42471555
110regulation of histone H3-K4 methylation (GO:0051569)3.40891100
111gene silencing (GO:0016458)3.39046356
112nuclear pore complex assembly (GO:0051292)3.38012341
113DNA methylation or demethylation (GO:0044728)3.37833289
114oocyte maturation (GO:0001556)3.35211609
115phosphorelay signal transduction system (GO:0000160)3.34849244
116regulation of histone methylation (GO:0031060)3.34565398
117negative regulation of execution phase of apoptosis (GO:1900118)3.32867298
118regulation of steroid hormone biosynthetic process (GO:0090030)3.31548110
119regulation of spindle checkpoint (GO:0090231)3.31182923
120DNA modification (GO:0006304)3.30547987
121relaxation of smooth muscle (GO:0044557)3.29887654
122negative regulation of reproductive process (GO:2000242)3.29372228
123regulation of centrosome cycle (GO:0046605)3.28328004
124regulation of histone H3-K9 methylation (GO:0051570)3.28160720
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.27179810
126regulation of reproductive process (GO:2000241)3.27064843
127negative regulation of nuclear division (GO:0051784)3.25255701
128maturation of 5.8S rRNA (GO:0000460)3.24939389
129gene silencing by RNA (GO:0031047)3.23644551
130negative regulation of cAMP-mediated signaling (GO:0043951)3.21388365
131regulation of nuclear cell cycle DNA replication (GO:0033262)3.21232963
132neuron fate determination (GO:0048664)3.20417289
133DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.19343814
134regulation of gene expression by genetic imprinting (GO:0006349)3.18892530
135nuclear pore organization (GO:0006999)3.18878475
136synaptonemal complex assembly (GO:0007130)3.18302027
137establishment of spindle localization (GO:0051293)3.17762200
138regulation of telomere maintenance via telomerase (GO:0032210)3.15961151
139centriole assembly (GO:0098534)3.15323762
140DNA replication initiation (GO:0006270)3.13907368
141N-terminal protein amino acid acetylation (GO:0006474)3.13863284
142regulation of centriole replication (GO:0046599)3.13557404
143negative regulation of mitosis (GO:0045839)3.12832141
144ribosome assembly (GO:0042255)3.11808506
145regulation of meiotic cell cycle (GO:0051445)3.11233488
146single fertilization (GO:0007338)3.10379977
147negative regulation of hormone biosynthetic process (GO:0032353)3.03940135
148phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.99228407
149regulation of chromatin silencing (GO:0031935)2.98508203
150* fertilization (GO:0009566)2.97279627
151nucleus organization (GO:0006997)2.96386825
152negative regulation of hormone metabolic process (GO:0032351)2.95817401
153histone H3-K9 demethylation (GO:0033169)2.93360119
154positive regulation of meiosis (GO:0045836)2.93197536
155regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.90923710

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.67816347
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.58426595
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.91129283
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.77071321
5SALL1_21062744_ChIP-ChIP_HESCs_Human4.32496577
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.15862973
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.79329448
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.92034513
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.91494468
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.75964340
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70784554
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.67069309
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.60300501
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.57812566
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.52528708
16NANOG_18555785_ChIP-Seq_MESCs_Mouse2.52356001
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.51029052
18AR_21909140_ChIP-Seq_LNCAP_Human2.48713997
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.48623790
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.48623790
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.48623790
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.28758201
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.23504435
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21963872
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20218436
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12391759
27TCF3_18692474_ChIP-Seq_MESCs_Mouse2.09673207
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09480138
29BP1_19119308_ChIP-ChIP_Hs578T_Human2.08621409
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06449123
31POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.05724152
32TCF3_18692474_ChIP-Seq_MEFs_Mouse2.03888599
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.00019426
34EZH2_22144423_ChIP-Seq_EOC_Human12.9801414
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.98360630
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96405071
37NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.90559263
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.90026725
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.89347829
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.89150036
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.81426135
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78290432
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.76053344
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75887194
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.73320607
46SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.71649304
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69763087
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69704292
49NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.66063322
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64248295
51GBX2_23144817_ChIP-Seq_PC3_Human1.64032149
52NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.61607251
53MYC_18940864_ChIP-ChIP_HL60_Human1.61512968
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59997908
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.55350045
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49404518
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.46076500
58NANOG_18692474_ChIP-Seq_MESCs_Mouse1.46010484
59TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.45792548
60NANOG_21062744_ChIP-ChIP_HESCs_Human1.44859635
61JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44497780
62POU5F1_16518401_ChIP-PET_MESCs_Mouse1.37814327
63ETS1_20019798_ChIP-Seq_JURKAT_Human1.36149543
64NANOG_18692474_ChIP-Seq_MEFs_Mouse1.34313971
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32323064
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.29136306
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24224243
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23542876
69IRF1_19129219_ChIP-ChIP_H3396_Human1.22909606
70TTF2_22483619_ChIP-Seq_HELA_Human1.22023354
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21717854
72* KAP1_27257070_Chip-Seq_ESCs_Mouse1.19519734
73POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.16399026
74FLI1_27457419_Chip-Seq_LIVER_Mouse1.16058331
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14950680
76HTT_18923047_ChIP-ChIP_STHdh_Human1.13683758
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.13159144
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12412698
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12052834
80VDR_23849224_ChIP-Seq_CD4+_Human1.11982407
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11237143
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.09914512
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09439494
84CBP_20019798_ChIP-Seq_JUKART_Human1.09439494
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.07997448
86SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07050506
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06972254
88* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06871045
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06499116
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04839809
91TCF4_23295773_ChIP-Seq_U87_Human1.04053787
92ZNF274_21170338_ChIP-Seq_K562_Hela1.02684778
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02281323
94SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01893321
95* NANOG_20526341_ChIP-Seq_ESCs_Human1.01516329
96POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01256624
97LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00544035
98PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.99841741
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99335523
100XRN2_22483619_ChIP-Seq_HELA_Human0.98883034
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98645727
102EWS_26573619_Chip-Seq_HEK293_Human0.97920953
103FUS_26573619_Chip-Seq_HEK293_Human0.96085867
104CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95223783
105GABP_19822575_ChIP-Seq_HepG2_Human0.93824961
106KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93319904
107CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93027854
108IGF1R_20145208_ChIP-Seq_DFB_Human0.92160336
109FOXP3_21729870_ChIP-Seq_TREG_Human0.92017910
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91494366
111FOXH1_21741376_ChIP-Seq_EPCs_Human0.91129888
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90588388
113AR_25329375_ChIP-Seq_VCAP_Human0.90351628
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90186437
115NANOG_16518401_ChIP-PET_MESCs_Mouse0.90034295
116RNF2_27304074_Chip-Seq_NSC_Mouse0.89144396
117SMAD4_21799915_ChIP-Seq_A2780_Human0.88262005
118FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88170088
119RUNX2_22187159_ChIP-Seq_PCA_Human0.87647054
120CBP_21632823_ChIP-Seq_H3396_Human0.87051995
121GF1_26923725_Chip-Seq_HPCs_Mouse0.86806679
122SOX2_16153702_ChIP-ChIP_HESCs_Human0.86056317
123TP53_22573176_ChIP-Seq_HFKS_Human0.85676538
124STAT3_18555785_ChIP-Seq_MESCs_Mouse0.85491234
125LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85198491
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84855628
127SMAD4_21741376_ChIP-Seq_EPCs_Human0.84235334
128HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.82140926
129DCP1A_22483619_ChIP-Seq_HELA_Human0.81833208
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80637150
131E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80379261
132RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79200687
133KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78170945
134SALL4_22934838_ChIP-ChIP_CD34+_Human0.77989855
135PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77792524
136YY1_21170310_ChIP-Seq_MESCs_Mouse0.77777418
137* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.77659165
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.77355035
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76892051
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.76892051
141YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76170260
142BMI1_23680149_ChIP-Seq_NPCS_Mouse0.74373392
143THAP11_20581084_ChIP-Seq_MESCs_Mouse0.73578257
144* STAT3_23295773_ChIP-Seq_U87_Human0.73317420
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.70833553
146TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.70546204
147PADI4_21655091_ChIP-ChIP_MCF-7_Human0.70166386
148P300_19829295_ChIP-Seq_ESCs_Human0.69219423
149GATA1_19941827_ChIP-Seq_MEL86_Mouse0.68968107
150PKCTHETA_26484144_Chip-Seq_BREAST_Human0.68490325
151SMRT_27268052_Chip-Seq_Bcells_Human0.66603031
152ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.66216744
153AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65796533
154SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.64809136
155AHR_22903824_ChIP-Seq_MCF-7_Human0.63626440
156GATA3_26560356_Chip-Seq_TH1_Human0.62937552
157VDR_22108803_ChIP-Seq_LS180_Human0.61538158
158KLF4_19829295_ChIP-Seq_ESCs_Human0.61334351
159NR3C1_23031785_ChIP-Seq_PC12_Mouse0.61036797
160SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.60902485
161AR_20517297_ChIP-Seq_VCAP_Human0.60050181
162TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.59909037
163BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.59654570
164NANOG_19829295_ChIP-Seq_ESCs_Human0.59019564
165SOX2_19829295_ChIP-Seq_ESCs_Human0.59019564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003718_maternal_effect5.29680340
2MP0003693_abnormal_embryo_hatching4.95053408
3MP0010094_abnormal_chromosome_stability4.30541495
4MP0004957_abnormal_blastocyst_morpholog3.95613972
5MP0003111_abnormal_nucleus_morphology3.67127940
6MP0003787_abnormal_imprinting3.62154054
7MP0003077_abnormal_cell_cycle3.54800575
8MP0008877_abnormal_DNA_methylation3.52143695
9MP0008057_abnormal_DNA_replication3.32462960
10MP0006292_abnormal_olfactory_placode3.00914967
11MP0002139_abnormal_hepatobiliary_system2.92453642
12MP0010234_abnormal_vibrissa_follicle2.88313714
13MP0003121_genomic_imprinting2.85646233
14MP0008058_abnormal_DNA_repair2.78848169
15MP0005360_urolithiasis2.78425387
16MP0002138_abnormal_hepatobiliary_system2.69955333
17MP0002653_abnormal_ependyma_morphology2.60582174
18MP0008932_abnormal_embryonic_tissue2.54605431
19MP0003646_muscle_fatigue2.54575079
20MP0001119_abnormal_female_reproductive2.42338474
21MP0003879_abnormal_hair_cell2.32682187
22MP0002234_abnormal_pharynx_morphology2.30408673
23MP0004264_abnormal_extraembryonic_tissu2.25036674
24* MP0003699_abnormal_female_reproductive2.22578556
25MP0002210_abnormal_sex_determination2.19088908
26MP0001929_abnormal_gametogenesis2.15427963
27* MP0005395_other_phenotype2.13383612
28MP0003136_yellow_coat_color2.04455993
29MP0005410_abnormal_fertilization2.02835063
30MP0000653_abnormal_sex_gland1.98162699
31MP0003806_abnormal_nucleotide_metabolis1.91728595
32MP0008007_abnormal_cellular_replicative1.89691663
33MP0000350_abnormal_cell_proliferation1.88804074
34MP0003183_abnormal_peptide_metabolism1.88532803
35MP0002102_abnormal_ear_morphology1.82427909
36MP0003315_abnormal_perineum_morphology1.78393003
37MP0003123_paternal_imprinting1.73469343
38MP0002085_abnormal_embryonic_tissue1.70174017
39MP0002249_abnormal_larynx_morphology1.67430722
40MP0001730_embryonic_growth_arrest1.64270010
41MP0001986_abnormal_taste_sensitivity1.58840087
42MP0001145_abnormal_male_reproductive1.58199386
43MP0003890_abnormal_embryonic-extraembry1.52019093
44MP0003937_abnormal_limbs/digits/tail_de1.50521042
45* MP0001672_abnormal_embryogenesis/_devel1.48215112
46* MP0005380_embryogenesis_phenotype1.48215112
47MP0005451_abnormal_body_composition1.47209501
48MP0002084_abnormal_developmental_patter1.42971037
49MP0001293_anophthalmia1.42854129
50MP0000579_abnormal_nail_morphology1.41156542
51MP0001919_abnormal_reproductive_system1.39713709
52MP0009840_abnormal_foam_cell1.38599643
53MP0001697_abnormal_embryo_size1.36648219
54MP0004133_heterotaxia1.31635316
55MP0003941_abnormal_skin_development1.27822369
56MP0005389_reproductive_system_phenotype1.26906031
57MP0003786_premature_aging1.26068298
58* MP0002161_abnormal_fertility/fecundity1.25529665
59MP0000631_abnormal_neuroendocrine_gland1.24532606
60MP0002233_abnormal_nose_morphology1.20311265
61MP0003950_abnormal_plasma_membrane1.18439702
62MP0010368_abnormal_lymphatic_system1.17880328
63MP0001984_abnormal_olfaction1.17350669
64MP0003252_abnormal_bile_duct1.15497239
65MP0002877_abnormal_melanocyte_morpholog1.15208826
66MP0010030_abnormal_orbit_morphology1.14946265
67MP0006072_abnormal_retinal_apoptosis1.12344347
68MP0003755_abnormal_palate_morphology1.10706613
69MP0002019_abnormal_tumor_incidence1.06668714
70MP0003984_embryonic_growth_retardation1.05390006
71MP0002086_abnormal_extraembryonic_tissu1.04305658
72MP0004142_abnormal_muscle_tone1.03754589
73MP0002088_abnormal_embryonic_growth/wei1.01686791
74MP0006276_abnormal_autonomic_nervous1.00022671
75MP0010352_gastrointestinal_tract_polyps0.97633847
76MP0000427_abnormal_hair_cycle0.97354465
77MP0000313_abnormal_cell_death0.96595942
78MP0000566_synostosis0.95671580
79MP0009379_abnormal_foot_pigmentation0.93296939
80MP0009697_abnormal_copulation0.92911752
81MP0010307_abnormal_tumor_latency0.91041720
82MP0001286_abnormal_eye_development0.90303368
83MP0002080_prenatal_lethality0.90223132
84MP0003119_abnormal_digestive_system0.90059409
85MP0003698_abnormal_male_reproductive0.88129992
86MP0000490_abnormal_crypts_of0.87498185
87MP0010678_abnormal_skin_adnexa0.87243756
88MP0002272_abnormal_nervous_system0.86276996
89MP0002796_impaired_skin_barrier0.84512765
90MP0005085_abnormal_gallbladder_physiolo0.84137867
91MP0001485_abnormal_pinna_reflex0.80392848
92MP0000049_abnormal_middle_ear0.79287535
93MP0005646_abnormal_pituitary_gland0.77611409
94MP0002160_abnormal_reproductive_system0.77166922
95MP0005551_abnormal_eye_electrophysiolog0.75963013
96MP0003861_abnormal_nervous_system0.75031061
97MP0002932_abnormal_joint_morphology0.74717896
98MP0001324_abnormal_eye_pigmentation0.74010238
99MP0003936_abnormal_reproductive_system0.73922877
100MP0003283_abnormal_digestive_organ0.73782280
101MP0000613_abnormal_salivary_gland0.73575584
102MP0000432_abnormal_head_morphology0.72991727
103MP0001666_abnormal_nutrient_absorption0.72428547
104MP0000678_abnormal_parathyroid_gland0.70747283
105MP0000015_abnormal_ear_pigmentation0.69244645
106MP0005621_abnormal_cell_physiology0.69122407
107MP0001502_abnormal_circadian_rhythm0.67926716
108MP0001346_abnormal_lacrimal_gland0.67602365
109MP0005408_hypopigmentation0.67033859
110MP0005384_cellular_phenotype0.66124069
111MP0005501_abnormal_skin_physiology0.66118796
112MP0000462_abnormal_digestive_system0.65311735
113MP0002111_abnormal_tail_morphology0.65210855
114MP0002127_abnormal_cardiovascular_syste0.65190043
115MP0003453_abnormal_keratinocyte_physiol0.64638234
116MP0005266_abnormal_metabolism0.64079862
117MP0005075_abnormal_melanosome_morpholog0.63844842
118MP0003186_abnormal_redox_activity0.63601337
119MP0002116_abnormal_craniofacial_bone0.62158576
120MP0008789_abnormal_olfactory_epithelium0.61656365
121MP0001664_abnormal_digestion0.61147863
122MP0003935_abnormal_craniofacial_develop0.57848690
123MP0008995_early_reproductive_senescence0.56055382
124MP0001915_intracranial_hemorrhage0.56040241
125MP0005394_taste/olfaction_phenotype0.55558153
126MP0005499_abnormal_olfactory_system0.55558153
127MP0004197_abnormal_fetal_growth/weight/0.54881045
128MP0002114_abnormal_axial_skeleton0.54277270
129MP0005023_abnormal_wound_healing0.53923897
130MP0001963_abnormal_hearing_physiology0.53316664
131MP0001905_abnormal_dopamine_level0.51935185
132MP0000762_abnormal_tongue_morphology0.51913190
133MP0005647_abnormal_sex_gland0.50909078
134MP0000627_abnormal_mammary_gland0.50900521
135MP0003938_abnormal_ear_development0.50640412
136MP0003868_abnormal_feces_composition0.50266589
137MP0003195_calcinosis0.49512905
138MP0002638_abnormal_pupillary_reflex0.46753304
139MP0002089_abnormal_postnatal_growth/wei0.45460201
140MP0002090_abnormal_vision0.44446586
141MP0002928_abnormal_bile_duct0.42159231
142MP0002873_normal_phenotype0.42034659
143MP0002735_abnormal_chemical_nociception0.41583677
144MP0002169_no_abnormal_phenotype0.41431048
145MP0000372_irregular_coat_pigmentation0.40654137
146MP0004381_abnormal_hair_follicle0.40470950
147MP0001881_abnormal_mammary_gland0.40168243
148MP0005174_abnormal_tail_pigmentation0.37977138
149MP0000026_abnormal_inner_ear0.37263552

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)7.55923279
2Chromsome breakage (HP:0040012)6.18034615
3Chromosomal breakage induced by crosslinking agents (HP:0003221)6.06960740
4Osteomalacia (HP:0002749)5.01962753
5Birth length less than 3rd percentile (HP:0003561)4.79537774
6Abnormality of the labia minora (HP:0012880)4.62034608
7Breast hypoplasia (HP:0003187)4.58780973
8Hypophosphatemic rickets (HP:0004912)4.36336545
9Septo-optic dysplasia (HP:0100842)4.07957197
10Supernumerary spleens (HP:0009799)4.07281764
11Azoospermia (HP:0000027)3.99378746
12Impulsivity (HP:0100710)3.94529363
13Anterior segment dysgenesis (HP:0007700)3.87603527
14Infertility (HP:0000789)3.83187700
15Patellar aplasia (HP:0006443)3.81833403
16Absent septum pellucidum (HP:0001331)3.69969986
17Premature ovarian failure (HP:0008209)3.65319273
18Median cleft lip (HP:0000161)3.61029819
19Gonadotropin excess (HP:0000837)3.60927841
20Short tibia (HP:0005736)3.54323438
21Absent radius (HP:0003974)3.53065343
22Aplasia/Hypoplasia of the patella (HP:0006498)3.51300734
23Shawl scrotum (HP:0000049)3.41771131
24Rhabdomyosarcoma (HP:0002859)3.39027638
25Aplasia/Hypoplasia of the uvula (HP:0010293)3.38554711
26Aplasia involving forearm bones (HP:0009822)3.36823153
27Absent forearm bone (HP:0003953)3.36823153
28Abnormality of chromosome stability (HP:0003220)3.31254646
29Medulloblastoma (HP:0002885)3.29729414
30Papillary thyroid carcinoma (HP:0002895)3.28390522
31Abnormality of the septum pellucidum (HP:0007375)3.24255346
32Meckel diverticulum (HP:0002245)3.21367934
33Abnormality of the preputium (HP:0100587)3.13778849
34Aplasia/Hypoplasia of the tibia (HP:0005772)3.12754613
35Abnormality of the ileum (HP:0001549)3.10947186
36Lip pit (HP:0100267)3.07801452
37Abnormal spermatogenesis (HP:0008669)3.04161690
38Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.03596634
39Enlarged penis (HP:0000040)2.94659702
40Aplasia/Hypoplasia of the macula (HP:0008059)2.90547348
41Wrist flexion contracture (HP:0001239)2.88957533
42Facial hemangioma (HP:0000329)2.82764220
43Flat capital femoral epiphysis (HP:0003370)2.81869682
44Adrenal hypoplasia (HP:0000835)2.81776263
45Sloping forehead (HP:0000340)2.81545805
46Neoplasm of the oral cavity (HP:0100649)2.80411365
47Hypokinesia (HP:0002375)2.78093853
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.77570880
49Carpal bone hypoplasia (HP:0001498)2.71079639
50Stillbirth (HP:0003826)2.70145226
51Duplicated collecting system (HP:0000081)2.68951626
52Conjunctival telangiectasia (HP:0000524)2.67636688
53Aplasia/Hypoplasia affecting the retina (HP:0008061)2.65605741
54Abnormality of the renal collecting system (HP:0004742)2.65412819
55Fair hair (HP:0002286)2.65300732
56Atelectasis (HP:0100750)2.65123188
57Small intestinal stenosis (HP:0012848)2.63803472
58Duodenal stenosis (HP:0100867)2.63803472
59Male infertility (HP:0003251)2.63055526
60Muscle stiffness (HP:0003552)2.60805866
61Neoplasm of striated muscle (HP:0009728)2.54050705
62Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.53781352
63Apathy (HP:0000741)2.53390492
64Sensory axonal neuropathy (HP:0003390)2.51784008
65Diminished motivation (HP:0000745)2.50395491
66Metaphyseal irregularity (HP:0003025)2.49132238
67Nephroblastoma (Wilms tumor) (HP:0002667)2.46412018
68Urethral obstruction (HP:0000796)2.45310062
69Proximal tubulopathy (HP:0000114)2.42664443
70Aplasia/Hypoplasia of the earlobes (HP:0009906)2.42048831
71Hypergonadotropic hypogonadism (HP:0000815)2.40247516
72Generalized aminoaciduria (HP:0002909)2.39494224
73Rib fusion (HP:0000902)2.38719784
74Secondary amenorrhea (HP:0000869)2.38407386
75Abdominal situs inversus (HP:0003363)2.37980820
76Abnormality of abdominal situs (HP:0011620)2.37980820
77Skin pits (HP:0100276)2.37856192
78Short thumb (HP:0009778)2.37624977
79Breast aplasia (HP:0100783)2.37304725
80Abnormality of the phalanges of the hallux (HP:0010057)2.36941434
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.36286283
82Truncal obesity (HP:0001956)2.35301933
83Spinal cord compression (HP:0002176)2.35181338
84Abnormality of chromosome segregation (HP:0002916)2.32768025
85Aplasia/Hypoplasia of the breasts (HP:0010311)2.30622704
86Abnormality of cochlea (HP:0000375)2.28381229
87Embryonal renal neoplasm (HP:0011794)2.27366640
88Loss of speech (HP:0002371)2.26808175
89Abnormal sex determination (HP:0012244)2.26777912
90Sex reversal (HP:0012245)2.26777912
91Ankle contracture (HP:0006466)2.26012674
92Ependymoma (HP:0002888)2.25360854
93Clubbing of toes (HP:0100760)2.25273678
94Abnormal ciliary motility (HP:0012262)2.21658587
95Aplasia/Hypoplasia of the fovea (HP:0008060)2.20824873
96Hypoplasia of the fovea (HP:0007750)2.20824873
97Intrahepatic cholestasis (HP:0001406)2.20259748
98Myokymia (HP:0002411)2.19290496
99Maternal diabetes (HP:0009800)2.18879371
100Abnormality of the proximal phalanges of the hand (HP:0009834)2.18732784
101Aplasia/Hypoplasia involving the musculature (HP:0001460)2.18562780
102Posterior subcapsular cataract (HP:0007787)2.18553668
103Bile duct proliferation (HP:0001408)2.18346035
104Abnormal biliary tract physiology (HP:0012439)2.18346035
105Insulin-resistant diabetes mellitus (HP:0000831)2.18245343
106Myelodysplasia (HP:0002863)2.15246670
107Ectopic kidney (HP:0000086)2.15198177
108Aplasia/Hypoplasia of the sternum (HP:0006714)2.15161703
109Aplasia of the musculature (HP:0100854)2.14689803
110Horseshoe kidney (HP:0000085)2.13851015
111Abnormality of the duodenum (HP:0002246)2.12349239
112Anhidrosis (HP:0000970)2.09133606
113Abnormality of the vasculature of the conjunctiva (HP:0008054)2.06149862
114Lower limb hyperreflexia (HP:0002395)2.05888537
115Agnosia (HP:0010524)2.04405238
116Abnormality of the fovea (HP:0000493)2.04007147
117Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.01965874
118Chronic bronchitis (HP:0004469)2.01822156
119Capillary hemangiomas (HP:0005306)2.01204080
120Triphalangeal thumb (HP:0001199)2.00511264
121Congenital sensorineural hearing impairment (HP:0008527)2.00262370
122Thyroid carcinoma (HP:0002890)1.98849853
123Oligodactyly (hands) (HP:0001180)1.98062008
124Colon cancer (HP:0003003)1.97275905
125Abnormality of the carotid arteries (HP:0005344)1.96716313
126Rhinitis (HP:0012384)1.96650856
127Pulmonary fibrosis (HP:0002206)1.96303979
128Sandal gap (HP:0001852)1.94876656
129Cleft eyelid (HP:0000625)1.94831607
130Acute myeloid leukemia (HP:0004808)1.94503396
131Bone marrow hypocellularity (HP:0005528)1.94322004
132Aplasia/hypoplasia of the humerus (HP:0006507)1.93790953
133Abnormality of calcium-phosphate metabolism (HP:0100530)1.93146481
134Absent thumb (HP:0009777)1.92776702
135Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.92521550
136Heterotopia (HP:0002282)1.91789870
137Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91371318
138Hypercortisolism (HP:0001578)1.91231720
139Generalized hypopigmentation of hair (HP:0011358)1.90556965
140Hip contracture (HP:0003273)1.89230545
141Prostate neoplasm (HP:0100787)1.89013391
142Striae distensae (HP:0001065)1.88069991
143Oligodactyly (HP:0012165)1.87644972
144Oral leukoplakia (HP:0002745)1.86509723
145Bicornuate uterus (HP:0000813)1.85856548
146Rickets (HP:0002748)1.84837563
147Microglossia (HP:0000171)1.84086942
148Bundle branch block (HP:0011710)1.83880112
149Dysdiadochokinesis (HP:0002075)1.83533362
150Selective tooth agenesis (HP:0001592)1.83008872
151Sparse lateral eyebrow (HP:0005338)1.81160064
152Abnormality of midbrain morphology (HP:0002418)1.80923327
153Molar tooth sign on MRI (HP:0002419)1.80923327
154Short humerus (HP:0005792)1.78331788
155Malnutrition (HP:0004395)1.77725200
156Abnormal lung lobation (HP:0002101)1.73424194
157Cholecystitis (HP:0001082)1.71572370
158Abnormal gallbladder physiology (HP:0012438)1.71572370
159Abnormality of the salivary glands (HP:0010286)1.70753027
160Aplasia/Hypoplasia of the ulna (HP:0006495)1.70101447
161Rectovaginal fistula (HP:0000143)1.69531173
162Rectal fistula (HP:0100590)1.69531173
163Villous atrophy (HP:0011473)1.69395475
164Abnormality of small intestinal villus morphology (HP:0011472)1.69395475
165Irregular epiphyses (HP:0010582)1.66571284

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.86698729
2TTK4.26483226
3MAP3K64.11384341
4PLK43.86808985
5BRAF3.13516906
6CDC73.04136894
7CHEK22.84718863
8BUB12.73897686
9LATS22.37085987
10STK38L2.35536206
11CDK122.32396734
12LATS12.29965916
13MET2.23903718
14PLK12.08910668
15MOS2.07639886
16STK102.07377871
17ERBB41.94158426
18EIF2AK31.89412984
19BMPR21.86131443
20NEK21.83109988
21MAP3K91.82640185
22WEE11.79280124
23MAPKAPK31.77336658
24RPS6KB21.69563818
25EIF2AK11.67072996
26EPHA21.65416798
27NEK11.49585773
28MAP3K81.47989093
29TRIM281.41360203
30CDK71.38461731
31AURKA1.37613045
32AURKB1.34719894
33KSR11.34641784
34AKT31.34099064
35CDK81.33278868
36MELK1.27342679
37ARAF1.23656675
38PRKD31.23245122
39MAP3K131.16220142
40CHEK11.14786883
41CDK191.12910916
42VRK11.11289127
43STK31.10637354
44DYRK21.10544132
45NUAK11.07712346
46MUSK1.06463339
47SRPK11.02071927
48BRSK11.01926448
49MAP3K40.99393427
50CDK90.99272901
51TYRO30.96696737
52ATR0.96593138
53ATM0.95714392
54MAP2K70.95566061
55PLK30.95035969
56ACVR1B0.94788904
57EEF2K0.92917394
58KSR20.91487874
59PNCK0.90893098
60NEK90.89800943
61STK390.89615728
62TAOK10.85193954
63TNIK0.84435180
64MAPK130.84319897
65TIE10.82555400
66ZAK0.81733378
67MST40.81578305
68MARK30.79546852
69CDK30.78008641
70NTRK30.74628053
71PINK10.73223734
72DMPK0.73081198
73CDK20.71560206
74CDK40.71534111
75WNK10.68108305
76PRKD20.66690094
77CDK10.61923657
78RAF10.61126902
79STK40.61097136
80PTK20.57621321
81CSNK1G10.56903897
82TNK20.53580863
83RPS6KA40.52967580
84PRKG10.52958894
85DYRK30.52875679
86LMTK20.52140755
87CSNK1E0.50546473
88TLK10.50014349
89NTRK20.49396005
90PDK20.48964000
91LRRK20.46163210
92PRKAA10.43602364
93TGFBR10.43222566
94PKN10.42662794
95PDK40.41187025
96PDK30.41187025
97PIM10.41065510
98MAP3K50.40401933
99STK240.40068778
100CSNK1D0.39958285
101PBK0.38027751
102PRKCI0.37514464
103NEK60.36719246
104STK380.36378124
105OXSR10.34647461
106MAPK140.34592289
107AKT10.34062197
108CAMK2A0.33870104
109CDK60.33825036
110BRSK20.33447879
111NLK0.32811046
112PRKCZ0.31200902
113CSNK2A10.30222551
114GSK3B0.30105724
115PLK20.29017157
116PRKACB0.28645648
117PRKACA0.26144149
118PRKAA20.25704175
119AKT20.25426035
120CDK50.25195739
121MAPK10.24729529
122PAK10.24065406
123MKNK20.23378166
124EIF2AK20.23185194
125TESK20.23134253
126MTOR0.21796545
127CSNK1G30.21501342
128ABL20.21332143
129MAP3K10.21258783
130CHUK0.21210062
131BMPR1B0.20740072
132PDK10.20385662
133ABL10.20071668
134CSNK1G20.18547449
135EGFR0.18485228
136CSNK1A1L0.16921576
137WNK40.15838143
138MAP2K10.15250848
139CSNK2A20.13040223
140CDK11A0.12778822

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.89648987
2Cell cycle_Homo sapiens_hsa041103.81269995
3Basal transcription factors_Homo sapiens_hsa030223.67998076
4DNA replication_Homo sapiens_hsa030303.67765572
5Homologous recombination_Homo sapiens_hsa034403.65275141
6Fanconi anemia pathway_Homo sapiens_hsa034603.64784937
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.59415055
8RNA transport_Homo sapiens_hsa030133.07298002
9Base excision repair_Homo sapiens_hsa034103.03767292
10RNA degradation_Homo sapiens_hsa030183.00936732
11Non-homologous end-joining_Homo sapiens_hsa034503.00907925
12Caffeine metabolism_Homo sapiens_hsa002322.94260935
13RNA polymerase_Homo sapiens_hsa030202.82380835
14p53 signaling pathway_Homo sapiens_hsa041152.62188188
15Nucleotide excision repair_Homo sapiens_hsa034202.61459222
16Ovarian steroidogenesis_Homo sapiens_hsa049131.95948248
17Olfactory transduction_Homo sapiens_hsa047401.88133474
18One carbon pool by folate_Homo sapiens_hsa006701.85633481
19Spliceosome_Homo sapiens_hsa030401.78547878
20Oocyte meiosis_Homo sapiens_hsa041141.73091835
21Pyrimidine metabolism_Homo sapiens_hsa002401.72744895
22Linoleic acid metabolism_Homo sapiens_hsa005911.71929760
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.70107724
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55511114
25Vitamin B6 metabolism_Homo sapiens_hsa007501.49181557
26Dorso-ventral axis formation_Homo sapiens_hsa043201.48624085
27mRNA surveillance pathway_Homo sapiens_hsa030151.47613968
28TGF-beta signaling pathway_Homo sapiens_hsa043501.40351829
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38181332
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.33171256
31MicroRNAs in cancer_Homo sapiens_hsa052061.27624744
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20520576
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20222376
34Ether lipid metabolism_Homo sapiens_hsa005651.18822113
35Proteasome_Homo sapiens_hsa030501.17684973
36Ribosome_Homo sapiens_hsa030101.14630565
37Gap junction_Homo sapiens_hsa045401.13849783
38Phototransduction_Homo sapiens_hsa047441.07282240
39Circadian rhythm_Homo sapiens_hsa047101.06329905
40Purine metabolism_Homo sapiens_hsa002301.04747996
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03863630
42Arachidonic acid metabolism_Homo sapiens_hsa005900.98698476
43ABC transporters_Homo sapiens_hsa020100.94548177
44Nicotine addiction_Homo sapiens_hsa050330.93764368
45Fatty acid elongation_Homo sapiens_hsa000620.93495483
46Folate biosynthesis_Homo sapiens_hsa007900.93224134
47Hippo signaling pathway_Homo sapiens_hsa043900.90644559
48Colorectal cancer_Homo sapiens_hsa052100.78097523
49Taste transduction_Homo sapiens_hsa047420.77821801
50Pancreatic cancer_Homo sapiens_hsa052120.75241962
51mTOR signaling pathway_Homo sapiens_hsa041500.70745217
52Epstein-Barr virus infection_Homo sapiens_hsa051690.70160658
53Synaptic vesicle cycle_Homo sapiens_hsa047210.69930195
54Bile secretion_Homo sapiens_hsa049760.67976754
55Morphine addiction_Homo sapiens_hsa050320.67400956
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65304629
57Herpes simplex infection_Homo sapiens_hsa051680.65227692
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61997971
59HTLV-I infection_Homo sapiens_hsa051660.61503733
60GABAergic synapse_Homo sapiens_hsa047270.59625644
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58331997
62Vitamin digestion and absorption_Homo sapiens_hsa049770.55307774
63Notch signaling pathway_Homo sapiens_hsa043300.54387799
64Thyroid cancer_Homo sapiens_hsa052160.53213627
65Glutathione metabolism_Homo sapiens_hsa004800.52988412
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51887341
67Systemic lupus erythematosus_Homo sapiens_hsa053220.51627786
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51539125
69Adherens junction_Homo sapiens_hsa045200.51288812
70Serotonergic synapse_Homo sapiens_hsa047260.49613001
71Hedgehog signaling pathway_Homo sapiens_hsa043400.48945314
72Choline metabolism in cancer_Homo sapiens_hsa052310.46498558
73Viral carcinogenesis_Homo sapiens_hsa052030.46166783
74Basal cell carcinoma_Homo sapiens_hsa052170.45481696
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45080861
76Huntingtons disease_Homo sapiens_hsa050160.44583963
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44293202
78FoxO signaling pathway_Homo sapiens_hsa040680.41687242
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.41660430
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39450792
81Bladder cancer_Homo sapiens_hsa052190.38355395
82Arginine and proline metabolism_Homo sapiens_hsa003300.38305078
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.38118365
84GnRH signaling pathway_Homo sapiens_hsa049120.33547800
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33125575
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33073172
87Melanoma_Homo sapiens_hsa052180.31914212
88Pathways in cancer_Homo sapiens_hsa052000.31898859
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29994332
90Wnt signaling pathway_Homo sapiens_hsa043100.29924737
91Tyrosine metabolism_Homo sapiens_hsa003500.29780158
92Regulation of autophagy_Homo sapiens_hsa041400.29753831
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.29678912
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28259560
95Small cell lung cancer_Homo sapiens_hsa052220.28152864
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27962688
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25581427
98Ras signaling pathway_Homo sapiens_hsa040140.25572887
99Cardiac muscle contraction_Homo sapiens_hsa042600.23558764
100Apoptosis_Homo sapiens_hsa042100.22866267
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22569000
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20768998
103Biosynthesis of amino acids_Homo sapiens_hsa012300.19962259
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19904736
105Steroid biosynthesis_Homo sapiens_hsa001000.18006697
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.17711842
107Inositol phosphate metabolism_Homo sapiens_hsa005620.17232310
108Metabolic pathways_Homo sapiens_hsa011000.16681430
109Propanoate metabolism_Homo sapiens_hsa006400.16523251
110Tight junction_Homo sapiens_hsa045300.16290691
111ErbB signaling pathway_Homo sapiens_hsa040120.16075401
112Lysine degradation_Homo sapiens_hsa003100.13493047
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.13360366
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.13283109
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.12948055
116Oxytocin signaling pathway_Homo sapiens_hsa049210.12514772
117Sphingolipid metabolism_Homo sapiens_hsa006000.11852759
118Prolactin signaling pathway_Homo sapiens_hsa049170.11266907
119Protein digestion and absorption_Homo sapiens_hsa049740.11048609
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10911324
121Prostate cancer_Homo sapiens_hsa052150.10701861
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10640935
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.08949177
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08752953
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.08080423
126cAMP signaling pathway_Homo sapiens_hsa040240.07019128
127Hepatitis B_Homo sapiens_hsa051610.06536841
128Shigellosis_Homo sapiens_hsa051310.06211115
129Long-term depression_Homo sapiens_hsa047300.05258255
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.04555646
131Renal cell carcinoma_Homo sapiens_hsa052110.03938447
132Arginine biosynthesis_Homo sapiens_hsa002200.03481127
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.02891544
134Endometrial cancer_Homo sapiens_hsa052130.01478041
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.01096083
136MAPK signaling pathway_Homo sapiens_hsa040100.00197267
137Retrograde endocannabinoid signaling_Homo sapiens_hsa04723-0.0002536

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