OOSP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H2A monoubiquitination (GO:0035518)6.93562333
2retinal cone cell development (GO:0046549)6.76682566
3female gamete generation (GO:0007292)6.60848935
4DNA methylation involved in gamete generation (GO:0043046)6.54329763
5citrulline biosynthetic process (GO:0019240)6.38940846
6histone H2A ubiquitination (GO:0033522)6.30027726
7protein K6-linked ubiquitination (GO:0085020)6.25221394
8regulation of exit from mitosis (GO:0007096)6.22944651
9regulation of meiosis (GO:0040020)6.21238107
10mitotic chromosome condensation (GO:0007076)6.13934197
11regulation of histone H3-K9 methylation (GO:0051570)6.11841827
12regulation of acrosome reaction (GO:0060046)6.10367730
13attachment of spindle microtubules to kinetochore (GO:0008608)6.08857983
14base-excision repair, AP site formation (GO:0006285)6.00226827
15mitotic metaphase plate congression (GO:0007080)5.98338407
16glycine transport (GO:0015816)5.98111097
17positive regulation of histone H3-K4 methylation (GO:0051571)5.85936227
18regulation of steroid hormone secretion (GO:2000831)5.75555265
19regulation of cell maturation (GO:1903429)5.75489201
20meiotic cell cycle (GO:0051321)5.73825442
21pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.56028057
22centriole replication (GO:0007099)5.48784880
23synapsis (GO:0007129)5.44412767
24negative regulation of meiosis (GO:0045835)5.44092232
25positive regulation of gastrulation (GO:2000543)5.40767483
26male meiosis (GO:0007140)5.40218133
27negative regulation of histone methylation (GO:0031061)5.27326205
28oocyte maturation (GO:0001556)5.15752705
29DNA damage induced protein phosphorylation (GO:0006975)5.13869480
30regulation of sister chromatid cohesion (GO:0007063)5.09995535
31negative regulation of smooth muscle cell differentiation (GO:0051151)5.00642443
32relaxation of smooth muscle (GO:0044557)4.98877428
33metaphase plate congression (GO:0051310)4.93729429
34establishment of chromosome localization (GO:0051303)4.85695210
35primitive streak formation (GO:0090009)4.85069876
36negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.84139804
37regulation of meiotic cell cycle (GO:0051445)4.84030974
38multicellular organism reproduction (GO:0032504)4.79641658
39negative regulation of cAMP-mediated signaling (GO:0043951)4.71571020
40pyrimidine nucleotide catabolic process (GO:0006244)4.61697286
41negative regulation of reproductive process (GO:2000242)4.60861762
42gene silencing by RNA (GO:0031047)4.60491078
43chromosome organization involved in meiosis (GO:0070192)4.59666460
44meiotic chromosome segregation (GO:0045132)4.55184804
45ovulation cycle (GO:0042698)4.51457938
46nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)4.46316492
47chaperone-mediated protein transport (GO:0072321)4.45937045
48male meiosis I (GO:0007141)4.45009315
49mitotic sister chromatid segregation (GO:0000070)4.42577368
50L-amino acid import (GO:0043092)4.34384660
51notochord development (GO:0030903)4.29700920
52regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.18164703
53microtubule severing (GO:0051013)4.17304023
54glycerophospholipid catabolic process (GO:0046475)4.06646762
55regulation of meiosis I (GO:0060631)4.06416645
56labyrinthine layer development (GO:0060711)4.01415214
57oocyte development (GO:0048599)3.99856306
58regulation of DNA methylation (GO:0044030)3.99336619
59regulation of histone H3-K27 methylation (GO:0061085)3.95646694
60negative regulation of meiotic cell cycle (GO:0051447)3.94234899
61DNA alkylation (GO:0006305)3.89711562
62DNA methylation (GO:0006306)3.89711562
63regulation of double-strand break repair via homologous recombination (GO:0010569)3.89105149
64CENP-A containing nucleosome assembly (GO:0034080)3.88629710
65meiotic nuclear division (GO:0007126)3.87419616
66positive regulation of meiosis (GO:0045836)3.85919302
67neuron fate determination (GO:0048664)3.85586344
68chromosome segregation (GO:0007059)3.83325538
69somite rostral/caudal axis specification (GO:0032525)3.77741061
70female gonad development (GO:0008585)3.75749933
71negative regulation of cardiac muscle hypertrophy (GO:0010614)3.75411008
72regulation of retinoic acid receptor signaling pathway (GO:0048385)3.73661037
73centriole assembly (GO:0098534)3.72851750
74positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.72387054
75pyrimidine-containing compound transmembrane transport (GO:0072531)3.71261761
76chromatin remodeling at centromere (GO:0031055)3.70210705
77citrulline metabolic process (GO:0000052)3.69629533
78peptidyl-arginine modification (GO:0018195)3.68730366
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.66650747
80regulation of spindle checkpoint (GO:0090231)3.64119237
81meiosis I (GO:0007127)3.62352859
82positive regulation of meiotic cell cycle (GO:0051446)3.61120365
83positive regulation of histone methylation (GO:0031062)3.60744851
84fertilization (GO:0009566)3.57235631
85protein localization to chromosome, centromeric region (GO:0071459)3.56083319
86maturation of 5.8S rRNA (GO:0000460)3.55124733
87protein localization to kinetochore (GO:0034501)3.54950620
88DNA replication-independent nucleosome organization (GO:0034724)3.53449900
89DNA replication-independent nucleosome assembly (GO:0006336)3.53449900
90sister chromatid segregation (GO:0000819)3.52601215
91genitalia morphogenesis (GO:0035112)3.52140867
92synaptonemal complex assembly (GO:0007130)3.51568084
93oogenesis (GO:0048477)3.51334565
94positive regulation of chromosome segregation (GO:0051984)3.51083255
95histone exchange (GO:0043486)3.49455552
96reproduction (GO:0000003)3.48544064
97regulation of spindle organization (GO:0090224)3.47046331
98translesion synthesis (GO:0019985)3.46563861
99positive regulation of uterine smooth muscle contraction (GO:0070474)3.44224235
100phosphorelay signal transduction system (GO:0000160)3.43715809
101centrosome duplication (GO:0051298)3.40040125
102protein localization to chromosome (GO:0034502)3.37926599
103pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.36405473
104dopamine biosynthetic process (GO:0042416)3.35320135
105regulation of steroid hormone biosynthetic process (GO:0090030)3.35006632
106regulation of mitotic spindle checkpoint (GO:1903504)3.34869440
107regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.34869440
108phosphatidylglycerol biosynthetic process (GO:0006655)3.33081681
109negative regulation of muscle hypertrophy (GO:0014741)3.33056402
110protein kinase C signaling (GO:0070528)3.32242246
111regulation of histone H3-K4 methylation (GO:0051569)3.31475152
112gene silencing (GO:0016458)3.30003919
113synaptonemal complex organization (GO:0070193)3.29827661
114DNA replication-dependent nucleosome organization (GO:0034723)3.28998543
115DNA replication-dependent nucleosome assembly (GO:0006335)3.28998543
116negative regulation of execution phase of apoptosis (GO:1900118)3.28378091
117positive regulation of microtubule polymerization (GO:0031116)3.26476136
118positive regulation of megakaryocyte differentiation (GO:0045654)3.26098982
119positive regulation of mitotic sister chromatid separation (GO:1901970)3.26018550
120positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.26018550
121positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.26018550
122negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.25762112
123negative regulation of DNA-templated transcription, elongation (GO:0032785)3.25762112
124mitotic sister chromatid cohesion (GO:0007064)3.24736690
125negative regulation of cell division (GO:0051782)3.23831675
126spindle checkpoint (GO:0031577)3.21737750
127regulation of chromosome segregation (GO:0051983)3.21489292
128regulation of mitotic spindle organization (GO:0060236)3.19739703
129cartilage morphogenesis (GO:0060536)3.18954028
130histone monoubiquitination (GO:0010390)3.16670887
131nucleus organization (GO:0006997)3.15713228
132negative regulation of hormone biosynthetic process (GO:0032353)3.15606290
133protein K11-linked ubiquitination (GO:0070979)3.15097610
134phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.13412064
135sphingosine metabolic process (GO:0006670)3.13324221
136meiotic cell cycle process (GO:1903046)3.13132257
137protein monoubiquitination (GO:0006513)3.12026661
138type B pancreatic cell development (GO:0003323)3.11592062
139mitotic nuclear envelope disassembly (GO:0007077)3.09933807
140kinetochore assembly (GO:0051382)3.08869607
141negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.08436126
142spermatid nucleus differentiation (GO:0007289)3.08236270
143negative regulation of hormone metabolic process (GO:0032351)3.07969500
144ventricular cardiac muscle cell development (GO:0055015)3.07928262
145regulation of hypersensitivity (GO:0002883)3.07863488
146protein deneddylation (GO:0000338)3.04771158
147regulation of histone methylation (GO:0031060)3.04012418
148kinetochore organization (GO:0051383)3.02088285
149positive regulation of humoral immune response (GO:0002922)3.00517169
150DNA damage response, signal transduction resulting in transcription (GO:0042772)3.00005534
151positive regulation of reproductive process (GO:2000243)2.98507327
152single fertilization (GO:0007338)2.98242230
153negative regulation of nuclear division (GO:0051784)2.98103792
154piRNA metabolic process (GO:0034587)10.7341344
155regulation of female gonad development (GO:2000194)10.1783732

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.67763036
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.47784911
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.10739347
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.44290064
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.67872770
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.86168411
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.86168411
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.86168411
9E2F7_22180533_ChIP-Seq_HELA_Human3.76357859
10KAP1_22055183_ChIP-Seq_ESCs_Mouse3.72979875
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.57691684
12SALL1_21062744_ChIP-ChIP_HESCs_Human3.53682385
13AR_21909140_ChIP-Seq_LNCAP_Human3.42739689
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.97090790
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.66400880
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.66131287
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.44269928
18MYC_18940864_ChIP-ChIP_HL60_Human2.31306958
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28539641
20GATA1_26923725_Chip-Seq_HPCs_Mouse2.17747663
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17238537
22GBX2_23144817_ChIP-Seq_PC3_Human2.10995985
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.01818277
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99269053
25IGF1R_20145208_ChIP-Seq_DFB_Human1.84690420
26MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.83348641
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.81039761
28RNF2_27304074_Chip-Seq_NSC_Mouse1.77062863
29IRF1_19129219_ChIP-ChIP_H3396_Human1.76638271
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.71394276
31LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67032389
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.59496911
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58361627
34SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55656244
35RUNX1_26923725_Chip-Seq_HPCs_Mouse1.54863873
36GATA3_21867929_ChIP-Seq_TH1_Mouse1.50800139
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50720319
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.49387053
39STAT1_17558387_ChIP-Seq_HELA_Human1.47676469
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.46995727
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44320439
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.39672192
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39274762
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39040307
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.36032977
46TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35273037
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35244691
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33998999
49HTT_18923047_ChIP-ChIP_STHdh_Human1.32527175
50NANOG_21062744_ChIP-ChIP_HESCs_Human1.31818025
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.31553789
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29478014
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28416802
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27596985
55CBP_20019798_ChIP-Seq_JUKART_Human1.27596985
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.27004820
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26400864
58NFYA_21822215_ChIP-Seq_K562_Human1.25313295
59CDX2_22108803_ChIP-Seq_LS180_Human1.25064374
60ELK4_26923725_Chip-Seq_MESODERM_Mouse1.24339550
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23585250
62SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.23408120
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23093534
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22431371
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22235710
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21497185
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21397142
68TP53_16413492_ChIP-PET_HCT116_Human1.15277861
69TCF4_23295773_ChIP-Seq_U87_Human1.14443285
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.13239839
71GATA3_26560356_Chip-Seq_TH1_Human1.13153083
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11962924
73SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11598125
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.11172458
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10894688
76GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08660635
77CTCF_18555785_Chip-Seq_ESCs_Mouse1.08212417
78GF1B_26923725_Chip-Seq_HPCs_Mouse1.07221598
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06899322
80ESR1_20079471_ChIP-ChIP_T-47D_Human1.06669587
81STAT3_23295773_ChIP-Seq_U87_Human1.06357517
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05816967
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05495739
84CBX2_22325352_ChIP-Seq_293T-Rex_Human1.05266496
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05149202
86ERG_20517297_ChIP-Seq_VCAP_Human1.04818048
87RBPJ_21746931_ChIP-Seq_IB4_Human1.04209315
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03894675
89EWS_26573619_Chip-Seq_HEK293_Human1.03727501
90HNFA_21074721_ChIP-Seq_CACO-2_Human1.03411288
91SMAD4_21799915_ChIP-Seq_A2780_Human1.03409005
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00568630
93ETV1_20927104_ChIP-Seq_GIST48_Human1.00512665
94AR_25329375_ChIP-Seq_VCAP_Human1.00362444
95FOXH1_21741376_ChIP-Seq_EPCs_Human1.00102618
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99689322
97ESET_19884257_ChIP-Seq_ESCs_Mouse0.99280014
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99208724
99TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99184209
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98807094
101KDM2B_26808549_Chip-Seq_REH_Human0.98320831
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97950164
103SALL4_22934838_ChIP-ChIP_CD34+_Human0.97540218
104P300_19829295_ChIP-Seq_ESCs_Human0.95945890
105ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95783987
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95656647
107GABP_19822575_ChIP-Seq_HepG2_Human0.95257700
108ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95011653
109TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94948218
110TAL1_26923725_Chip-Seq_HPCs_Mouse0.94897390
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94694858
112CRX_20693478_ChIP-Seq_RETINA_Mouse0.94358974
113ZFX_18555785_Chip-Seq_ESCs_Mouse0.92598488
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92549550
115NANOG_20526341_ChIP-Seq_ESCs_Human0.92165677
116CBP_21632823_ChIP-Seq_H3396_Human0.91446740
117KLF4_18555785_Chip-Seq_ESCs_Mouse0.90894744
118OCT4_18555785_Chip-Seq_ESCs_Mouse0.90688271
119AHR_22903824_ChIP-Seq_MCF-7_Human0.90455024
120GATA6_21074721_ChIP-Seq_CACO-2_Human0.90436217
121NMYC_18555785_Chip-Seq_ESCs_Mouse0.89991865
122RUNX2_22187159_ChIP-Seq_PCA_Human0.89764448
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89537476
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89442748
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89386910
126SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89306297
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.89141756
128CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89046091
129EZH2_22144423_ChIP-Seq_EOC_Human0.88406726
130NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88197337
131LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87700288
132CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87494885
133GF1_26923725_Chip-Seq_HPCs_Mouse0.87333933
134OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87313851
135PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87100360
136PHF8_20622853_ChIP-Seq_HELA_Human0.86188054
137TBL1_22424771_ChIP-Seq_293T_Human0.85960731
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85492259
139FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84867087
140CREB1_15753290_ChIP-ChIP_HEK293T_Human0.84436331
141SMAD4_21741376_ChIP-Seq_EPCs_Human0.82173249
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80224682
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80103509
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80103509
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.77174418
146ZNF274_21170338_ChIP-Seq_K562_Hela0.76733279
147TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.75354052
148PADI4_21655091_ChIP-ChIP_MCF-7_Human0.74027085
149FUS_26573619_Chip-Seq_HEK293_Human0.72217835
150SMRT_27268052_Chip-Seq_Bcells_Human0.70262523
151TP53_22573176_ChIP-Seq_HFKS_Human0.70133323
152SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.69892751
153ARNT_22903824_ChIP-Seq_MCF-7_Human0.69726197
154NANOG_19829295_ChIP-Seq_ESCs_Human0.68232627
155SOX2_19829295_ChIP-Seq_ESCs_Human0.68232627
156STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.67963826
157VDR_22108803_ChIP-Seq_LS180_Human0.67193425
158NR3C1_23031785_ChIP-Seq_PC12_Mouse0.67028260
159BMI1_23680149_ChIP-Seq_NPCS_Mouse0.67013542
160TBX3_20139965_ChIP-Seq_ESCs_Mouse0.66544893
161CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.66428198
162TBX3_20139965_ChIP-Seq_MESCs_Mouse0.65924412
163ZNF217_24962896_ChIP-Seq_MCF-7_Human0.64208890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.66042395
2MP0003646_muscle_fatigue6.77381550
3MP0008789_abnormal_olfactory_epithelium5.08398556
4MP0005394_taste/olfaction_phenotype4.45243794
5MP0005499_abnormal_olfactory_system4.45243794
6MP0008877_abnormal_DNA_methylation4.28416806
7MP0005451_abnormal_body_composition4.23944179
8MP0003693_abnormal_embryo_hatching4.04154574
9MP0005395_other_phenotype3.39529975
10MP0002138_abnormal_hepatobiliary_system3.15918786
11MP0003699_abnormal_female_reproductive3.14061411
12MP0001119_abnormal_female_reproductive2.90601590
13MP0010030_abnormal_orbit_morphology2.88273168
14MP0010094_abnormal_chromosome_stability2.87853772
15MP0003077_abnormal_cell_cycle2.73755444
16MP0005646_abnormal_pituitary_gland2.72952059
17MP0003315_abnormal_perineum_morphology2.64844022
18MP0004957_abnormal_blastocyst_morpholog2.62701739
19MP0002102_abnormal_ear_morphology2.59697863
20MP0002234_abnormal_pharynx_morphology2.59216914
21MP0000579_abnormal_nail_morphology2.58260327
22MP0001929_abnormal_gametogenesis2.56380049
23MP0002653_abnormal_ependyma_morphology2.44782224
24MP0003111_abnormal_nucleus_morphology2.43782078
25MP0000653_abnormal_sex_gland2.32352706
26MP0002210_abnormal_sex_determination2.25565537
27MP0008057_abnormal_DNA_replication2.24524692
28MP0005410_abnormal_fertilization2.15497281
29MP0003787_abnormal_imprinting2.14086055
30MP0003183_abnormal_peptide_metabolism2.06146862
31MP0005187_abnormal_penis_morphology1.98471078
32MP0003879_abnormal_hair_cell1.97850347
33MP0005408_hypopigmentation1.86275632
34MP0003937_abnormal_limbs/digits/tail_de1.82548358
35MP0002160_abnormal_reproductive_system1.78516261
36MP0002249_abnormal_larynx_morphology1.73598411
37MP0008932_abnormal_embryonic_tissue1.73417306
38MP0006292_abnormal_olfactory_placode1.68612537
39MP0001984_abnormal_olfaction1.67208667
40MP0003121_genomic_imprinting1.64584491
41MP0002161_abnormal_fertility/fecundity1.61534067
42MP0004264_abnormal_extraembryonic_tissu1.56535047
43MP0001145_abnormal_male_reproductive1.50758482
44MP0001293_anophthalmia1.43290825
45MP0000566_synostosis1.41559774
46MP0003252_abnormal_bile_duct1.41396099
47MP0001529_abnormal_vocalization1.40978294
48MP0010307_abnormal_tumor_latency1.37124464
49MP0000762_abnormal_tongue_morphology1.35248234
50MP0008260_abnormal_autophagy1.34920737
51MP0003950_abnormal_plasma_membrane1.31752726
52MP0001905_abnormal_dopamine_level1.31368469
53MP0005310_abnormal_salivary_gland1.26191050
54MP0000613_abnormal_salivary_gland1.25068945
55MP0000639_abnormal_adrenal_gland1.23057718
56MP0005257_abnormal_intraocular_pressure1.22555208
57MP0001730_embryonic_growth_arrest1.21428928
58MP0002233_abnormal_nose_morphology1.19055474
59MP0003123_paternal_imprinting1.18235796
60MP0002085_abnormal_embryonic_tissue1.16269195
61MP0000350_abnormal_cell_proliferation1.14464647
62MP0010234_abnormal_vibrissa_follicle1.12914021
63MP0002295_abnormal_pulmonary_circulatio1.08809702
64MP0010368_abnormal_lymphatic_system1.06836844
65MP0005085_abnormal_gallbladder_physiolo1.06679387
66MP0005360_urolithiasis1.04604096
67MP0010386_abnormal_urinary_bladder1.04120696
68MP0001986_abnormal_taste_sensitivity1.02203510
69MP0002019_abnormal_tumor_incidence0.98317450
70MP0001919_abnormal_reproductive_system0.97847259
71MP0002282_abnormal_trachea_morphology0.96921621
72MP0009384_cardiac_valve_regurgitation0.94580929
73MP0001346_abnormal_lacrimal_gland0.93996655
74MP0004185_abnormal_adipocyte_glucose0.93082761
75MP0004142_abnormal_muscle_tone0.91153728
76MP0009697_abnormal_copulation0.87618346
77MP0005389_reproductive_system_phenotype0.85942237
78MP0001672_abnormal_embryogenesis/_devel0.84403345
79MP0005380_embryogenesis_phenotype0.84403345
80MP0001697_abnormal_embryo_size0.84168532
81MP0000490_abnormal_crypts_of0.83315171
82MP0002084_abnormal_developmental_patter0.80800299
83MP0003119_abnormal_digestive_system0.80150020
84MP0002877_abnormal_melanocyte_morpholog0.79529593
85MP0002796_impaired_skin_barrier0.78988936
86MP0006276_abnormal_autonomic_nervous0.78827648
87MP0010678_abnormal_skin_adnexa0.78719674
88MP0003453_abnormal_keratinocyte_physiol0.78238501
89MP0002272_abnormal_nervous_system0.77421895
90MP0003763_abnormal_thymus_physiology0.75556265
91MP0003868_abnormal_feces_composition0.75359226
92MP0003698_abnormal_male_reproductive0.75244660
93MP0001666_abnormal_nutrient_absorption0.73691088
94MP0002139_abnormal_hepatobiliary_system0.73416201
95MP0005551_abnormal_eye_electrophysiolog0.72917599
96MP0008058_abnormal_DNA_repair0.71505551
97MP0008875_abnormal_xenobiotic_pharmacok0.70584828
98MP0008007_abnormal_cellular_replicative0.69484741
99MP0004036_abnormal_muscle_relaxation0.69413056
100MP0004782_abnormal_surfactant_physiolog0.68705716
101MP0000049_abnormal_middle_ear0.68643922
102MP0001324_abnormal_eye_pigmentation0.68493875
103MP0000462_abnormal_digestive_system0.66961045
104MP0003755_abnormal_palate_morphology0.66755400
105MP0005621_abnormal_cell_physiology0.66487847
106MP0004145_abnormal_muscle_electrophysio0.62319992
107MP0004510_myositis0.61473667
108MP0009379_abnormal_foot_pigmentation0.61385324
109MP0000427_abnormal_hair_cycle0.58610485
110MP0001915_intracranial_hemorrhage0.58595452
111MP0009840_abnormal_foam_cell0.58411573
112MP0002932_abnormal_joint_morphology0.58388967
113MP0006072_abnormal_retinal_apoptosis0.58165460
114MP0002332_abnormal_exercise_endurance0.57755908
115MP0000678_abnormal_parathyroid_gland0.57242214
116MP0002928_abnormal_bile_duct0.55813854
117MP0001664_abnormal_digestion0.55773712
118MP0005501_abnormal_skin_physiology0.55117381
119MP0005647_abnormal_sex_gland0.54925314
120MP0001502_abnormal_circadian_rhythm0.54134497
121MP0003890_abnormal_embryonic-extraembry0.51832383
122MP0003656_abnormal_erythrocyte_physiolo0.51623760
123MP0002127_abnormal_cardiovascular_syste0.51617594
124MP0006138_congestive_heart_failure0.51188347
125MP0005075_abnormal_melanosome_morpholog0.51073757
126MP0002269_muscular_atrophy0.50979876
127MP0002090_abnormal_vision0.50888873
128MP0003136_yellow_coat_color0.50236472
129MP0002638_abnormal_pupillary_reflex0.49283928
130MP0002080_prenatal_lethality0.49084367
131MP0005503_abnormal_tendon_morphology0.48877003
132MP0002396_abnormal_hematopoietic_system0.47275808
133MP0003941_abnormal_skin_development0.47262212
134MP0005384_cellular_phenotype0.46569839
135MP0001851_eye_inflammation0.45197005
136MP0002751_abnormal_autonomic_nervous0.44972328
137MP0003942_abnormal_urinary_system0.43976966
138MP0001963_abnormal_hearing_physiology0.43625442
139MP0002163_abnormal_gland_morphology0.42579310
140MP0002109_abnormal_limb_morphology0.42390151
141MP0003935_abnormal_craniofacial_develop0.41958467
142MP0002168_other_aberrant_phenotype0.41038480
143MP0002177_abnormal_outer_ear0.40283515
144MP0000631_abnormal_neuroendocrine_gland0.40040978
145MP0002089_abnormal_postnatal_growth/wei0.38760252
146MP0005220_abnormal_exocrine_pancreas0.38462332
147MP0004043_abnormal_pH_regulation0.38213879
148MP0003861_abnormal_nervous_system0.37710893
149MP0004484_altered_response_of0.37627373
150MP0000428_abnormal_craniofacial_morphol0.37283296
151MP0004084_abnormal_cardiac_muscle0.36041059
152MP0002837_dystrophic_cardiac_calcinosis0.35823977
153MP0003195_calcinosis0.34116691
154MP0000015_abnormal_ear_pigmentation0.33245556
155MP0003984_embryonic_growth_retardation0.33141683
156MP0000377_abnormal_hair_follicle0.32372189
157MP0002873_normal_phenotype0.32105677
158MP0000026_abnormal_inner_ear0.31839658
159MP0002169_no_abnormal_phenotype0.31662269
160MP0005197_abnormal_uvea_morphology0.31146302

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)9.53894699
2Cortical dysplasia (HP:0002539)7.39927480
3Premature ovarian failure (HP:0008209)5.65328135
4Infertility (HP:0000789)5.10117576
5Abnormality of abdominal situs (HP:0011620)4.94425373
6Abdominal situs inversus (HP:0003363)4.94425373
7Birth length less than 3rd percentile (HP:0003561)4.71458112
8Secondary amenorrhea (HP:0000869)4.66031709
9Papillary thyroid carcinoma (HP:0002895)4.55413724
10Osteomalacia (HP:0002749)4.52890422
11Breast hypoplasia (HP:0003187)4.47551031
12Chromsome breakage (HP:0040012)4.47542310
13Septo-optic dysplasia (HP:0100842)4.46510051
14Absent septum pellucidum (HP:0001331)4.25791219
15Flat capital femoral epiphysis (HP:0003370)4.22664510
16Short tibia (HP:0005736)4.19678134
17Chromosomal breakage induced by crosslinking agents (HP:0003221)4.10520060
18Hypophosphatemic rickets (HP:0004912)4.05853537
19Enlarged penis (HP:0000040)3.99766890
20Median cleft lip (HP:0000161)3.93130802
21Abnormality of the septum pellucidum (HP:0007375)3.87659425
22Pulmonary fibrosis (HP:0002206)3.78032772
23Azoospermia (HP:0000027)3.75874051
24Aplasia/Hypoplasia of the tibia (HP:0005772)3.74616103
25Hypergonadotropic hypogonadism (HP:0000815)3.66279332
26Impulsivity (HP:0100710)3.65467329
27Patellar aplasia (HP:0006443)3.64566644
28Adrenal hypoplasia (HP:0000835)3.63420131
29Gonadotropin excess (HP:0000837)3.50556820
30Abnormality of the fovea (HP:0000493)3.48679536
31Oligodactyly (HP:0012165)3.45643282
32Stillbirth (HP:0003826)3.43809217
33Insulin-resistant diabetes mellitus (HP:0000831)3.38718724
34Aplasia/Hypoplasia of the breasts (HP:0010311)3.35174866
35Abnormality of the labia minora (HP:0012880)3.34847827
36Fair hair (HP:0002286)3.34463643
37Aplasia/Hypoplasia of the patella (HP:0006498)3.31584397
38Shawl scrotum (HP:0000049)3.31564729
39Breast aplasia (HP:0100783)3.29256258
40Hypoplasia of the fovea (HP:0007750)3.26590910
41Aplasia/Hypoplasia of the fovea (HP:0008060)3.26590910
42Anosmia (HP:0000458)3.26040718
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.21233150
44Facial hemangioma (HP:0000329)3.17051472
45Abnormality of the phalanges of the hallux (HP:0010057)3.15946489
46Atelectasis (HP:0100750)3.13787769
47Cholecystitis (HP:0001082)3.09580834
48Abnormal gallbladder physiology (HP:0012438)3.09580834
49Ankle contracture (HP:0006466)3.08479608
50Arterial tortuosity (HP:0005116)3.06495760
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.00152468
52Intrahepatic cholestasis (HP:0001406)2.94136911
53Nonprogressive disorder (HP:0003680)2.90551654
54Abnormal spermatogenesis (HP:0008669)2.82421543
55Sensory axonal neuropathy (HP:0003390)2.81756903
56Primary amenorrhea (HP:0000786)2.80101415
57Urethral obstruction (HP:0000796)2.77395035
58Abnormality of alanine metabolism (HP:0010916)2.70291612
59Hyperalaninemia (HP:0003348)2.70291612
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70291612
61Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.69283414
62Apathy (HP:0000741)2.65124048
63Anterior segment dysgenesis (HP:0007700)2.63357075
64Muscle stiffness (HP:0003552)2.63351332
65Vascular tortuosity (HP:0004948)2.62296009
66Abnormality of chromosome segregation (HP:0002916)2.61212360
67Bile duct proliferation (HP:0001408)2.58946137
68Abnormal biliary tract physiology (HP:0012439)2.58946137
69Hypokinesia (HP:0002375)2.57449342
70Diminished motivation (HP:0000745)2.57315866
71Spondylolisthesis (HP:0003302)2.55748065
72Chronic bronchitis (HP:0004469)2.53316719
73Conjunctival telangiectasia (HP:0000524)2.52625448
74Malnutrition (HP:0004395)2.48473667
75Papilledema (HP:0001085)2.48285397
76Hypogonadotrophic hypogonadism (HP:0000044)2.46798799
77Abnormal lung lobation (HP:0002101)2.45658818
78Supernumerary spleens (HP:0009799)2.45106544
79Capillary hemangiomas (HP:0005306)2.43700821
80Generalized hypopigmentation of hair (HP:0011358)2.42732270
81Metaphyseal irregularity (HP:0003025)2.40618096
82Maternal diabetes (HP:0009800)2.39436289
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.36985390
84Spinal cord compression (HP:0002176)2.36755888
85Hip contracture (HP:0003273)2.35111652
86Oral leukoplakia (HP:0002745)2.33219572
87Abnormal ciliary motility (HP:0012262)2.32175646
88Thyroid carcinoma (HP:0002890)2.30643228
89Bicornuate uterus (HP:0000813)2.30244719
90Shallow orbits (HP:0000586)2.29186574
91Abnormality of chromosome stability (HP:0003220)2.29020697
92Proximal tubulopathy (HP:0000114)2.27485541
93Amniotic constriction ring (HP:0009775)2.27395107
94Abnormality of placental membranes (HP:0011409)2.27395107
95Acute myeloid leukemia (HP:0004808)2.25038291
96Heterotopia (HP:0002282)2.24981763
97Aplastic anemia (HP:0001915)2.21676212
98Abnormality of the proximal phalanges of the hand (HP:0009834)2.20830229
99Fibular aplasia (HP:0002990)2.20322912
100Limb hypertonia (HP:0002509)2.20239379
101Sandal gap (HP:0001852)2.19401020
102Abnormality of aromatic amino acid family metabolism (HP:0004338)2.18706429
103Lower limb hyperreflexia (HP:0002395)2.17445322
104Bronchiectasis (HP:0002110)2.16146392
105Oligodactyly (hands) (HP:0001180)2.15660304
106Nephroblastoma (Wilms tumor) (HP:0002667)2.14727812
107Delayed puberty (HP:0000823)2.13939697
108Bundle branch block (HP:0011710)2.13141506
109Aplasia/Hypoplasia of the uvula (HP:0010293)2.12746956
110Hyperglycemia (HP:0003074)2.11747333
111Aplasia/Hypoplasia of the macula (HP:0008059)2.11316102
112Skin pits (HP:0100276)2.11201954
113Congenital sensorineural hearing impairment (HP:0008527)2.10417692
114Sloping forehead (HP:0000340)2.09079164
115Steatorrhea (HP:0002570)2.08836216
116Aplasia of the musculature (HP:0100854)2.08185989
117Rhinitis (HP:0012384)2.08161905
118Muscle fiber atrophy (HP:0100295)2.07843119
119Hydroureter (HP:0000072)2.06020784
120Abnormality of the preputium (HP:0100587)2.05766046
121Chorioretinal atrophy (HP:0000533)2.05583409
122Truncal obesity (HP:0001956)2.05466128
123Abnormality of the epiphysis of the femoral head (HP:0010574)2.04443593
124Abnormality of monocarboxylic acid metabolism (HP:0010996)2.04281159
125Dysdiadochokinesis (HP:0002075)2.03532361
126Type 2 muscle fiber atrophy (HP:0003554)2.02279927
127Embryonal renal neoplasm (HP:0011794)2.01243355
128Striae distensae (HP:0001065)1.99247538
129Absent radius (HP:0003974)1.98470440
130Aplasia involving forearm bones (HP:0009822)1.97236204
131Absent forearm bone (HP:0003953)1.97236204
132Rhabdomyosarcoma (HP:0002859)1.95916398
133Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95625225
134Aplasia/Hypoplasia affecting the retina (HP:0008061)1.95380681
135Posterior embryotoxon (HP:0000627)1.94430393
136Wrist flexion contracture (HP:0001239)1.93492810
137Myokymia (HP:0002411)1.93172121
138Generalized aminoaciduria (HP:0002909)1.92962998
139Meckel diverticulum (HP:0002245)1.92420078
140Abnormality of the femoral head (HP:0003368)1.92035577
141Molar tooth sign on MRI (HP:0002419)1.91963522
142Abnormality of midbrain morphology (HP:0002418)1.91963522
143Villous atrophy (HP:0011473)1.91257543
144Abnormality of small intestinal villus morphology (HP:0011472)1.91257543
145Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.90624416
146Abnormality of the fingertips (HP:0001211)1.89516254
147Cranial hyperostosis (HP:0004437)1.89349167
148Small intestinal stenosis (HP:0012848)1.87858382
149Duodenal stenosis (HP:0100867)1.87858382
150Fetal akinesia sequence (HP:0001989)1.87816373
151Midline defect of the nose (HP:0004122)1.86601155
152Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.85935874
153Camptodactyly of toe (HP:0001836)1.85828865
154Absent hand (HP:0004050)1.85828737
155Posterior subcapsular cataract (HP:0007787)1.85154549
156Deep venous thrombosis (HP:0002625)1.84482056
157Abnormality of femoral epiphyses (HP:0006499)1.82878898
158Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.82878898
159Lip pit (HP:0100267)1.81267274
160Abnormality of the line of Schwalbe (HP:0008048)1.81197109
161Cleft eyelid (HP:0000625)1.81133965
162Carpal bone hypoplasia (HP:0001498)1.80822921
163Loss of speech (HP:0002371)1.80059717
164Abnormal respiratory motile cilium physiology (HP:0012261)1.79424115
165Cystic hygroma (HP:0000476)1.77963911
166Arachnodactyly (HP:0001166)1.76209899
167Aplasia of the phalanges of the hand (HP:0009802)1.75878230

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K65.53265043
2TAOK34.50390975
3LATS13.91486434
4ERBB43.80256237
5NEK63.77366392
6KSR23.56557787
7LATS23.50910606
8MAP3K92.99807633
9MOS2.76587858
10BRAF2.72149739
11MET2.68426928
12MAP3K132.67609283
13TTK2.58078496
14STK38L2.57250195
15PRKD32.52142303
16MUSK2.49535200
17EEF2K2.48296063
18PLK42.44753202
19ARAF2.34824594
20CDK82.25392860
21EIF2AK32.14886129
22PRKCI1.98155807
23RAF11.87409470
24BMPR21.82847108
25CHEK21.80645508
26CDC71.67842050
27STK31.60559273
28STK101.60223773
29MELK1.57733558
30MAP3K41.55773084
31ZAK1.53771218
32MAPKAPK31.46827159
33MAP2K71.44832737
34NEK21.37799113
35TAOK11.36517917
36DYRK21.28851878
37TNIK1.27184949
38MAP3K81.22699034
39MAPK131.20274846
40NUAK11.16790194
41PLK11.16693760
42KSR11.14687252
43CDK121.12659375
44TRIM281.11976556
45STK391.08166622
46MAPKAPK51.07106259
47CDK91.06820939
48MST41.03372932
49PAK60.97970225
50TIE10.95548652
51MAP2K40.89877628
52BUB10.88677324
53ABL20.85003024
54MARK30.82681414
55DMPK0.82310437
56RET0.82097345
57PRKD20.78022273
58BRSK20.77706485
59AURKA0.74907567
60CSNK1G10.73993865
61STK240.72238636
62ACVR1B0.71166254
63AURKB0.70258998
64TYRO30.69651291
65TNK20.66968410
66STK380.66281023
67PINK10.60205763
68PRKAA10.60179488
69CDK190.59103257
70PRKG10.58336370
71MAP3K50.57421713
72CSNK1G30.56877435
73EIF2AK10.56380706
74CSNK1G20.55828391
75SRPK10.55752304
76PKN10.52743765
77TGFBR10.49772961
78PLK30.49760882
79WNK10.48763649
80NTRK30.48632784
81OXSR10.47381515
82MAP3K10.47249449
83PRKAA20.46550410
84MAPK110.45528035
85LMTK20.44754818
86NEK90.42779164
87CHEK10.41596008
88TRPM70.40425826
89PAK10.40009703
90MAP3K20.39996283
91NLK0.39435218
92CHUK0.39243430
93RPS6KB20.39011165
94ATM0.38517210
95CDK70.38503719
96HIPK20.38347212
97VRK10.37484771
98CDK30.37044340
99ABL10.36644099
100CSNK1A1L0.34439029
101NTRK20.34164964
102LRRK20.34160643
103CSNK1E0.33498445
104PTK20.30267635
105PRKCZ0.29551038
106PRKACA0.29436333
107CDK50.26664880
108PRKACB0.25916992
109CDK10.25256502
110EIF2AK20.24633114
111TLK10.24382992
112MAP2K10.21440674
113EGFR0.20774992
114MTOR0.20441502
115CDK40.19485406
116CDK20.19218360
117CSNK1D0.16779646
118PBK0.16739660
119PDK10.16361104
120GSK3B0.15539373
121RPS6KA40.15158074
122CAMK2A0.15087487
123JAK30.14955795
124AKT10.13815504
125AKT20.13620529
126SGK20.13279245
127PLK20.12818160
128KIT0.12456276
129EPHA40.11249745
130NEK10.11119845
131CDK11A0.10890103
132SGK4940.10731518
133SGK2230.10731518
134TESK20.10605699
135BMPR1B0.10021879
136BRSK10.09476634
137ATR0.08236271
138FGR0.07642975
139PIM10.07011808
140NTRK10.06597280
141JAK20.06026757
142CSNK1A10.05801053
143MAPK10.05286080

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.18990516
2Cell cycle_Homo sapiens_hsa041103.80671224
3Caffeine metabolism_Homo sapiens_hsa002323.78667023
4Basal transcription factors_Homo sapiens_hsa030223.70925470
5Vitamin B6 metabolism_Homo sapiens_hsa007503.65545250
6RNA degradation_Homo sapiens_hsa030183.44489975
7Oocyte meiosis_Homo sapiens_hsa041142.41270366
8Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.30870607
9Homologous recombination_Homo sapiens_hsa034402.27191004
10Circadian rhythm_Homo sapiens_hsa047102.27058109
11Pancreatic cancer_Homo sapiens_hsa052122.26368334
12Dorso-ventral axis formation_Homo sapiens_hsa043202.25451196
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.23431240
14Fanconi anemia pathway_Homo sapiens_hsa034602.19474970
15Base excision repair_Homo sapiens_hsa034102.18017837
16Linoleic acid metabolism_Homo sapiens_hsa005912.16663149
17RNA transport_Homo sapiens_hsa030132.09168376
18Olfactory transduction_Homo sapiens_hsa047402.06887170
19RNA polymerase_Homo sapiens_hsa030202.03785136
20GnRH signaling pathway_Homo sapiens_hsa049121.98609629
21Ether lipid metabolism_Homo sapiens_hsa005651.96873385
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.82128097
23Non-homologous end-joining_Homo sapiens_hsa034501.70338853
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70147579
25p53 signaling pathway_Homo sapiens_hsa041151.68240233
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67668008
27mTOR signaling pathway_Homo sapiens_hsa041501.52821690
28TGF-beta signaling pathway_Homo sapiens_hsa043501.45167021
29Colorectal cancer_Homo sapiens_hsa052101.42095795
30MicroRNAs in cancer_Homo sapiens_hsa052061.40248864
31DNA replication_Homo sapiens_hsa030301.38206400
32Nicotine addiction_Homo sapiens_hsa050331.36920768
33Nucleotide excision repair_Homo sapiens_hsa034201.35801748
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35310606
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35120333
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.27360266
37Prolactin signaling pathway_Homo sapiens_hsa049171.21022022
38VEGF signaling pathway_Homo sapiens_hsa043701.17243568
39Choline metabolism in cancer_Homo sapiens_hsa052311.17143697
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16870755
41Protein export_Homo sapiens_hsa030601.16312285
42Renal cell carcinoma_Homo sapiens_hsa052111.11181693
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06722256
44ABC transporters_Homo sapiens_hsa020101.06282163
45Phototransduction_Homo sapiens_hsa047441.02461355
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.00960316
47Synaptic vesicle cycle_Homo sapiens_hsa047211.00919137
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96651909
49Long-term depression_Homo sapiens_hsa047300.96221968
50mRNA surveillance pathway_Homo sapiens_hsa030150.95522822
51Other glycan degradation_Homo sapiens_hsa005110.94817231
52Bladder cancer_Homo sapiens_hsa052190.93068469
53Morphine addiction_Homo sapiens_hsa050320.91726607
54Mismatch repair_Homo sapiens_hsa034300.89323928
55Vitamin digestion and absorption_Homo sapiens_hsa049770.84207907
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83971609
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83061813
58GABAergic synapse_Homo sapiens_hsa047270.82192681
59Bile secretion_Homo sapiens_hsa049760.79686886
60Pyrimidine metabolism_Homo sapiens_hsa002400.75602741
61Folate biosynthesis_Homo sapiens_hsa007900.75249743
62Non-small cell lung cancer_Homo sapiens_hsa052230.72857572
63Inositol phosphate metabolism_Homo sapiens_hsa005620.69507830
64Purine metabolism_Homo sapiens_hsa002300.69003355
65Thyroid cancer_Homo sapiens_hsa052160.68574314
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67385107
67Ras signaling pathway_Homo sapiens_hsa040140.66386794
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64418551
69Shigellosis_Homo sapiens_hsa051310.64113409
70Fatty acid elongation_Homo sapiens_hsa000620.63928532
71Taste transduction_Homo sapiens_hsa047420.63482756
72Viral carcinogenesis_Homo sapiens_hsa052030.62867979
73Hippo signaling pathway_Homo sapiens_hsa043900.61681637
74Endometrial cancer_Homo sapiens_hsa052130.61644628
75FoxO signaling pathway_Homo sapiens_hsa040680.61415816
76HTLV-I infection_Homo sapiens_hsa051660.61317033
77Sphingolipid metabolism_Homo sapiens_hsa006000.59172848
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.56799824
79Chronic myeloid leukemia_Homo sapiens_hsa052200.55696109
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54207902
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45091805
82Hepatitis B_Homo sapiens_hsa051610.44737464
83Estrogen signaling pathway_Homo sapiens_hsa049150.40982637
84Glioma_Homo sapiens_hsa052140.39804698
85Small cell lung cancer_Homo sapiens_hsa052220.39504719
86MAPK signaling pathway_Homo sapiens_hsa040100.39131008
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39082490
88Herpes simplex infection_Homo sapiens_hsa051680.38413015
89Adherens junction_Homo sapiens_hsa045200.37167763
90Serotonergic synapse_Homo sapiens_hsa047260.36497092
91Malaria_Homo sapiens_hsa051440.35003141
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34981726
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.34870952
94Regulation of autophagy_Homo sapiens_hsa041400.34735197
95Melanoma_Homo sapiens_hsa052180.34601647
96Arachidonic acid metabolism_Homo sapiens_hsa005900.34410597
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33485374
98Oxytocin signaling pathway_Homo sapiens_hsa049210.32150410
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31895655
100Notch signaling pathway_Homo sapiens_hsa043300.31315017
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30576703
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.30537636
103Propanoate metabolism_Homo sapiens_hsa006400.30520568
104Arginine and proline metabolism_Homo sapiens_hsa003300.30159896
105Pyruvate metabolism_Homo sapiens_hsa006200.29510265
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28826332
107Histidine metabolism_Homo sapiens_hsa003400.26664652
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.25710846
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24719746
110Prostate cancer_Homo sapiens_hsa052150.24596094
111Spliceosome_Homo sapiens_hsa030400.24563487
112ErbB signaling pathway_Homo sapiens_hsa040120.24190229
113Glutamatergic synapse_Homo sapiens_hsa047240.23732406
114beta-Alanine metabolism_Homo sapiens_hsa004100.21359166
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21242785
116HIF-1 signaling pathway_Homo sapiens_hsa040660.19252188
117Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18785362
118Insulin signaling pathway_Homo sapiens_hsa049100.17578283
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.16246384
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15901516
121Gap junction_Homo sapiens_hsa045400.15619576
122cAMP signaling pathway_Homo sapiens_hsa040240.15291735
123Long-term potentiation_Homo sapiens_hsa047200.14627981
124Protein digestion and absorption_Homo sapiens_hsa049740.14390870
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.14059331
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13563124
127Arginine biosynthesis_Homo sapiens_hsa002200.13311663
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13286431
129Wnt signaling pathway_Homo sapiens_hsa043100.12721393
130Huntingtons disease_Homo sapiens_hsa050160.10777447
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.10472074
132Phagosome_Homo sapiens_hsa041450.08507639
133Cholinergic synapse_Homo sapiens_hsa047250.06151937
134Pathways in cancer_Homo sapiens_hsa052000.04132647
135Circadian entrainment_Homo sapiens_hsa047130.03615337
136Cardiac muscle contraction_Homo sapiens_hsa042600.01903317
137Dopaminergic synapse_Homo sapiens_hsa047280.01793076
138Epstein-Barr virus infection_Homo sapiens_hsa051690.01126189

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