OPALIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.88576931
2ensheathment of neurons (GO:0007272)7.55471521
3axon ensheathment (GO:0008366)7.55471521
4myelination (GO:0042552)7.52136674
5synaptic vesicle docking involved in exocytosis (GO:0016081)7.37645957
6synaptic vesicle maturation (GO:0016188)7.32288257
7glutamate secretion (GO:0014047)6.76025599
8synaptic vesicle exocytosis (GO:0016079)6.10780522
9long-chain fatty acid biosynthetic process (GO:0042759)6.10318527
10cellular potassium ion homeostasis (GO:0030007)5.86062051
11regulation of short-term neuronal synaptic plasticity (GO:0048172)5.73442929
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.69643903
13regulation of synaptic vesicle exocytosis (GO:2000300)5.68534925
14negative regulation of neurotransmitter secretion (GO:0046929)5.45809468
15oligodendrocyte differentiation (GO:0048709)5.34622839
16sodium ion export (GO:0071436)5.24363671
17amino acid import (GO:0043090)5.23711659
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.16939469
19myelin maintenance (GO:0043217)5.07095624
20virion attachment to host cell (GO:0019062)4.96731103
21adhesion of symbiont to host cell (GO:0044650)4.96731103
22regulation of synaptic vesicle transport (GO:1902803)4.95289429
23neurotransmitter secretion (GO:0007269)4.85240571
24glycerophospholipid catabolic process (GO:0046475)4.79959866
25regulation of neuronal synaptic plasticity (GO:0048168)4.77605527
26creatine metabolic process (GO:0006600)4.75391223
27locomotory exploration behavior (GO:0035641)4.71900215
28cholesterol biosynthetic process (GO:0006695)4.66646828
29apical protein localization (GO:0045176)4.62771904
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.59221993
31asymmetric protein localization (GO:0008105)4.53892166
32negative regulation of neurotransmitter transport (GO:0051589)4.52754773
33astrocyte development (GO:0014002)4.50262955
34ionotropic glutamate receptor signaling pathway (GO:0035235)4.45602219
35presynaptic membrane organization (GO:0097090)4.40582790
36potassium ion homeostasis (GO:0055075)4.37759469
37cerebellar granule cell differentiation (GO:0021707)4.27833470
38presynaptic membrane assembly (GO:0097105)4.27250261
39negative regulation of protein localization to cell surface (GO:2000009)4.25540197
40peptidyl-tyrosine autophosphorylation (GO:0038083)4.23737671
41potassium ion import (GO:0010107)4.23439773
42establishment of mitochondrion localization (GO:0051654)4.23143027
43neuronal action potential propagation (GO:0019227)4.22972650
44photoreceptor cell differentiation (GO:0046530)4.21684917
45eye photoreceptor cell differentiation (GO:0001754)4.21684917
46regulation of long-term neuronal synaptic plasticity (GO:0048169)4.18378515
47substantia nigra development (GO:0021762)4.16552412
48negative regulation of synaptic transmission, GABAergic (GO:0032229)4.14847938
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.11860643
50regulation of collateral sprouting (GO:0048670)4.09855868
51positive regulation of oligodendrocyte differentiation (GO:0048714)4.04755763
52sterol biosynthetic process (GO:0016126)4.04438077
53vocalization behavior (GO:0071625)4.03277490
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.03055860
55neurotransmitter transport (GO:0006836)4.02030384
56exploration behavior (GO:0035640)3.97150751
57positive regulation of synapse maturation (GO:0090129)3.96735079
58response to redox state (GO:0051775)3.93032944
59synaptic transmission, glutamatergic (GO:0035249)3.92005944
60positive regulation of action potential (GO:0045760)3.91202330
61neurotransmitter uptake (GO:0001504)3.85954042
62positive regulation of dendritic spine development (GO:0060999)3.81830646
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.81567688
64regulation of synaptic plasticity (GO:0048167)3.79753112
65postsynaptic membrane organization (GO:0001941)3.79518279
66long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.78896412
67adhesion of symbiont to host (GO:0044406)3.77378613
68cerebellar Purkinje cell differentiation (GO:0021702)3.75925196
69acidic amino acid transport (GO:0015800)3.73442997
70negative regulation of JUN kinase activity (GO:0043508)3.71524889
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.70766066
72regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.70662867
73regulation of neurotransmitter levels (GO:0001505)3.67201478
74regulation of glutamate receptor signaling pathway (GO:1900449)3.65984711
75neuron-neuron synaptic transmission (GO:0007270)3.65934590
76regulation of ARF protein signal transduction (GO:0032012)3.62984948
77regulation of neurotransmitter secretion (GO:0046928)3.62977269
78myelination in peripheral nervous system (GO:0022011)3.61264746
79peripheral nervous system axon ensheathment (GO:0032292)3.61264746
80positive regulation of membrane potential (GO:0045838)3.60778508
81isoprenoid biosynthetic process (GO:0008299)3.60593370
82membrane tubulation (GO:0097320)3.59550296
83neuromuscular process controlling balance (GO:0050885)3.58804354
84regulation of voltage-gated calcium channel activity (GO:1901385)3.58587196
85glutamate receptor signaling pathway (GO:0007215)3.58521083
86import into cell (GO:0098657)3.58249848
87GPI anchor biosynthetic process (GO:0006506)3.57623130
88negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.56957626
89protein palmitoylation (GO:0018345)3.56247856
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.55685703
91regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54508977
92protein localization to synapse (GO:0035418)3.47865973
93neurotransmitter-gated ion channel clustering (GO:0072578)3.46663582
94GPI anchor metabolic process (GO:0006505)3.46217682
95gamma-aminobutyric acid transport (GO:0015812)3.45750833
96phosphorelay signal transduction system (GO:0000160)3.45739142
97response to lipoprotein particle (GO:0055094)3.45129110
98negative regulation of dendrite morphogenesis (GO:0050774)3.43773876
99positive regulation of Rap GTPase activity (GO:0032854)3.42969233
100amyloid precursor protein metabolic process (GO:0042982)3.42164697
101long-term synaptic potentiation (GO:0060291)3.42088915
102cell communication by electrical coupling (GO:0010644)3.41800104
103long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.39701466
104regulation of neurotransmitter transport (GO:0051588)3.38666984
105cellular sodium ion homeostasis (GO:0006883)3.38614394
106L-glutamate transport (GO:0015813)3.35059271
107negative regulation of inclusion body assembly (GO:0090084)3.31165685
108fatty-acyl-CoA biosynthetic process (GO:0046949)3.30669177
109synaptic vesicle endocytosis (GO:0048488)3.30587251
110regulation of dendritic spine development (GO:0060998)3.29241728
111limb bud formation (GO:0060174)3.29072277
112L-amino acid import (GO:0043092)3.28811098
113negative regulation of axonogenesis (GO:0050771)3.25416874
114transmission of nerve impulse (GO:0019226)3.23665480
115regulation of postsynaptic membrane potential (GO:0060078)3.23025681
116regulation of Rap GTPase activity (GO:0032317)3.21203876
117glycosylceramide metabolic process (GO:0006677)3.21175105
118nucleotide transmembrane transport (GO:1901679)3.20961008
119long-term memory (GO:0007616)3.19797415
120cellular response to epinephrine stimulus (GO:0071872)3.19772991
121adult walking behavior (GO:0007628)3.18672242
122magnesium ion transport (GO:0015693)3.18048429
123leukocyte migration involved in inflammatory response (GO:0002523)3.16672787
124regulation of synapse maturation (GO:0090128)3.16592392
125regulation of synapse structural plasticity (GO:0051823)3.16215293
126cerebral cortex radially oriented cell migration (GO:0021799)3.15793798
127preassembly of GPI anchor in ER membrane (GO:0016254)3.14724355
128cytoskeletal anchoring at plasma membrane (GO:0007016)3.14378397
129positive regulation of neurotransmitter secretion (GO:0001956)3.13170188
130membrane depolarization during action potential (GO:0086010)3.11306003
131regulation of synaptic transmission (GO:0050804)3.11187629
132regulation of dendritic spine morphogenesis (GO:0061001)3.10774161
133regulation of vesicle fusion (GO:0031338)3.09920305
134glial cell development (GO:0021782)3.08708085
135axon development (GO:0061564)3.07131121
136positive regulation of dendrite development (GO:1900006)3.04317271
137positive regulation of neurotransmitter transport (GO:0051590)3.02931617
138neuron cell-cell adhesion (GO:0007158)3.02449796
139fatty-acyl-CoA metabolic process (GO:0035337)3.01839701
140ear development (GO:0043583)3.01821528
141positive regulation of cellular amine metabolic process (GO:0033240)3.01259745
142peptidyl-cysteine modification (GO:0018198)2.99878456
143membrane depolarization (GO:0051899)2.97916726
144negative regulation of acute inflammatory response (GO:0002674)2.97753084
145interleukin-6-mediated signaling pathway (GO:0070102)2.94684544
146positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.92236277
147regulation of synaptic transmission, glutamatergic (GO:0051966)2.92065012
148synaptic transmission (GO:0007268)2.91221594
149regulation of synaptic transmission, GABAergic (GO:0032228)2.88922370
150cell differentiation in hindbrain (GO:0021533)2.88326272
151peripheral nervous system development (GO:0007422)2.86454599
152response to methylmercury (GO:0051597)2.85854412
153L-serine transport (GO:0015825)2.84673340
154positive regulation of glial cell differentiation (GO:0045687)2.84081255
155Leydig cell differentiation (GO:0033327)2.83436757
156very long-chain fatty acid metabolic process (GO:0000038)2.80208592
157membrane assembly (GO:0071709)2.79896084
158negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.79443014
159amyloid precursor protein catabolic process (GO:0042987)2.79138015
160response to epinephrine (GO:0071871)2.79116065
161neuron remodeling (GO:0016322)2.78300313
162neural nucleus development (GO:0048857)2.77511357
163neurotransmitter catabolic process (GO:0042135)2.74336863
164histone H2B ubiquitination (GO:0033523)2.70262192
165organ growth (GO:0035265)2.68875973
166microtubule polymerization or depolymerization (GO:0031109)2.67890345
167neuronal ion channel clustering (GO:0045161)2.67858434
168negative regulation of axon extension (GO:0030517)2.66235788
169mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.66130701
170glial cell differentiation (GO:0010001)2.64673725
171response to lead ion (GO:0010288)2.63259688
172erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.62499733
173L-phenylalanine catabolic process (GO:0006559)2.62499733
174positive regulation of interleukin-17 production (GO:0032740)2.61582254
175negative regulation of execution phase of apoptosis (GO:1900118)2.61389335
176acyl-CoA biosynthetic process (GO:0071616)2.61057648
177thioester biosynthetic process (GO:0035384)2.61057648
178heme transport (GO:0015886)2.60851875
179positive regulation of gliogenesis (GO:0014015)2.60573543
180protein localization to endosome (GO:0036010)2.60397789
181iron coordination entity transport (GO:1901678)2.58510303
182central nervous system myelination (GO:0022010)11.9310603
183axon ensheathment in central nervous system (GO:0032291)11.9310603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.56253473
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.16438178
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.92699466
4SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.78115746
5TAF15_26573619_Chip-Seq_HEK293_Human2.62687165
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.56948472
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56138416
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.36697784
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27116970
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.21952077
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16068321
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.14723034
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12158238
14OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.06161923
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.05651054
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94223748
17ER_23166858_ChIP-Seq_MCF-7_Human1.93248026
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90993339
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90993339
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89990095
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89724273
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88641423
23VDR_22108803_ChIP-Seq_LS180_Human1.88107949
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79163866
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.78318264
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78282198
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77808956
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75332481
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73289890
30* EZH2_27294783_Chip-Seq_ESCs_Mouse1.72697118
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.68758270
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67085004
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.66062685
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63522302
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63024065
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60026202
37RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.59626065
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56389933
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.55320304
40STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.54762349
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54550644
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52886882
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52286295
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49934201
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48442611
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.47742854
47DROSHA_22980978_ChIP-Seq_HELA_Human1.47164765
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.46780663
49AR_21572438_ChIP-Seq_LNCaP_Human1.43709088
50CTNNB1_20460455_ChIP-Seq_HCT116_Human1.42571920
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38504589
52FUS_26573619_Chip-Seq_HEK293_Human1.36246110
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36013357
54KDM2B_26808549_Chip-Seq_K562_Human1.34469267
55EZH2_22144423_ChIP-Seq_EOC_Human1.34106658
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32565947
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.31863662
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30860146
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29949528
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29490541
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29488474
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.28345661
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27736581
64SMAD4_21799915_ChIP-Seq_A2780_Human1.25061386
65CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24889685
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.23280508
67AR_19668381_ChIP-Seq_PC3_Human1.23020318
68SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.22410731
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21565336
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.21183943
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19485744
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.18848427
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17533383
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16371115
75NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16371115
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15888450
77EOMES_21245162_ChIP-Seq_HESCs_Human1.15640835
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.15388896
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15285965
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14448803
81TRIM28_21343339_ChIP-Seq_HEK293_Human1.13869527
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13768265
83P300_19829295_ChIP-Seq_ESCs_Human1.13591957
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13552669
85FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12056589
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11939759
87TET1_21490601_ChIP-Seq_MESCs_Mouse1.11281294
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.10894841
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10612265
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08897996
91LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08023068
92HTT_18923047_ChIP-ChIP_STHdh_Human1.07241956
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.07125562
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07079397
95RNF2_27304074_Chip-Seq_NSC_Mouse1.06726759
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05968566
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05820389
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04455755
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03894310
100IRF1_19129219_ChIP-ChIP_H3396_Human1.02340910
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01582689
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01509670
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.01336627
104EP300_21415370_ChIP-Seq_HL-1_Mouse1.00182387
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99763682
106STAT3_23295773_ChIP-Seq_U87_Human0.99702733
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99575368
108GATA1_26923725_Chip-Seq_HPCs_Mouse0.99539913
109SMAD_19615063_ChIP-ChIP_OVARY_Human0.98930172
110P300_18555785_Chip-Seq_ESCs_Mouse0.98535791
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98139119
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97914386
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97805075
114SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97339897
115REST_21632747_ChIP-Seq_MESCs_Mouse0.96840178
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95574535
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95449224
118BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94123329
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.94087435
120RING1B_27294783_Chip-Seq_NPCs_Mouse0.93841590
121TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92922325
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92489870
123TCF4_23295773_ChIP-Seq_U87_Human0.92331474
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92018169
125AHR_22903824_ChIP-Seq_MCF-7_Human0.91901197
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91688403
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91211197
128* SMAD3_21741376_ChIP-Seq_ESCs_Human0.91201926
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90854955
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90392560
131NANOG_19829295_ChIP-Seq_ESCs_Human0.89861736
132SOX2_19829295_ChIP-Seq_ESCs_Human0.89861736
133* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89197056
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88832565
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.88767344
136OCT4_19829295_ChIP-Seq_ESCs_Human0.88284883
137TP53_16413492_ChIP-PET_HCT116_Human0.88134987
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87557603
139* TBL1_22424771_ChIP-Seq_293T_Human0.86736221
140EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86408730
141POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85495064
142* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85021414
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.84924129
144SOX9_26525672_Chip-Seq_HEART_Mouse0.84512365
145REST_18959480_ChIP-ChIP_MESCs_Mouse0.84150618
146CTCF_27219007_Chip-Seq_Bcells_Human0.81895734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.91405158
2MP0003950_abnormal_plasma_membrane3.95424838
3MP0003880_abnormal_central_pattern3.83760385
4MP0004270_analgesia3.53222811
5MP0003690_abnormal_glial_cell3.17324753
6MP0004885_abnormal_endolymph2.77013551
7MP0003136_yellow_coat_color2.74484835
8MP0001529_abnormal_vocalization2.71826699
9MP0001905_abnormal_dopamine_level2.61593381
10MP0003329_amyloid_beta_deposits2.59241418
11MP0005171_absent_coat_pigmentation2.51215556
12MP0003634_abnormal_glial_cell2.49213099
13MP0004742_abnormal_vestibular_system2.45566665
14MP0005451_abnormal_body_composition2.41331902
15MP0002272_abnormal_nervous_system2.37717480
16MP0004142_abnormal_muscle_tone2.31346873
17MP0001486_abnormal_startle_reflex2.27817716
18MP0001485_abnormal_pinna_reflex2.26545377
19MP0005409_darkened_coat_color2.13427974
20MP0001501_abnormal_sleep_pattern2.12965885
21MP0000778_abnormal_nervous_system2.09430391
22MP0003879_abnormal_hair_cell2.07122265
23MP0003806_abnormal_nucleotide_metabolis2.05916435
24MP0002064_seizures2.02928647
25MP0002229_neurodegeneration1.95951621
26MP0005410_abnormal_fertilization1.93134210
27MP0003632_abnormal_nervous_system1.90275228
28MP0009780_abnormal_chondrocyte_physiolo1.90251434
29MP0004147_increased_porphyrin_level1.90163239
30MP0004859_abnormal_synaptic_plasticity1.88388411
31MP0000383_abnormal_hair_follicle1.88015881
32MP0010678_abnormal_skin_adnexa1.79820095
33MP0004381_abnormal_hair_follicle1.79173581
34MP0001984_abnormal_olfaction1.77519080
35MP0000462_abnormal_digestive_system1.77176218
36MP0009046_muscle_twitch1.75209718
37MP0004811_abnormal_neuron_physiology1.74612505
38MP0005646_abnormal_pituitary_gland1.69674539
39MP0002736_abnormal_nociception_after1.63931909
40MP0002734_abnormal_mechanical_nocicepti1.63716669
41MP0004043_abnormal_pH_regulation1.59196171
42MP0001661_extended_life_span1.53053566
43MP0009745_abnormal_behavioral_response1.51830836
44MP0001346_abnormal_lacrimal_gland1.50110278
45MP0003787_abnormal_imprinting1.49090863
46MP0000955_abnormal_spinal_cord1.46225176
47MP0000566_synostosis1.46202980
48MP0003635_abnormal_synaptic_transmissio1.41509658
49MP0001502_abnormal_circadian_rhythm1.38841752
50MP0002557_abnormal_social/conspecific_i1.36323280
51MP0005423_abnormal_somatic_nervous1.34622171
52MP0000604_amyloidosis1.34006221
53MP0005551_abnormal_eye_electrophysiolog1.33756626
54MP0002882_abnormal_neuron_morphology1.32004390
55MP0004134_abnormal_chest_morphology1.25654288
56MP0001440_abnormal_grooming_behavior1.24744792
57MP0001299_abnormal_eye_distance/1.22263087
58MP0008260_abnormal_autophagy1.21331633
59MP0001963_abnormal_hearing_physiology1.20134757
60MP0002066_abnormal_motor_capabilities/c1.18019794
61MP0002752_abnormal_somatic_nervous1.17326510
62MP0003631_nervous_system_phenotype1.17051864
63MP0000747_muscle_weakness1.15859851
64MP0004924_abnormal_behavior1.12676507
65MP0005386_behavior/neurological_phenoty1.12676507
66MP0005408_hypopigmentation1.12645615
67MP0001851_eye_inflammation1.09389066
68MP0002572_abnormal_emotion/affect_behav1.06980966
69MP0005167_abnormal_blood-brain_barrier1.05446310
70MP0008438_abnormal_cutaneous_collagen1.04735467
71MP0003938_abnormal_ear_development1.04325639
72MP0006082_CNS_inflammation1.02386928
73MP0001348_abnormal_lacrimal_gland1.01879161
74MP0008874_decreased_physiological_sensi1.01642328
75MP0003123_paternal_imprinting1.01249287
76MP0006276_abnormal_autonomic_nervous1.00739184
77MP0001970_abnormal_pain_threshold1.00390154
78MP0005058_abnormal_lysosome_morphology1.00251747
79MP0003075_altered_response_to0.99741606
80MP0002067_abnormal_sensory_capabilities0.99674774
81MP0005195_abnormal_posterior_eye0.99361457
82MP0002822_catalepsy0.98899913
83MP0005623_abnormal_meninges_morphology0.97046449
84MP0003195_calcinosis0.96694489
85MP0008569_lethality_at_weaning0.96034781
86MP0003937_abnormal_limbs/digits/tail_de0.94777995
87MP0004185_abnormal_adipocyte_glucose0.94072765
88MP0000762_abnormal_tongue_morphology0.93064005
89MP0000647_abnormal_sebaceous_gland0.92074673
90MP0001727_abnormal_embryo_implantation0.91983961
91MP0002295_abnormal_pulmonary_circulatio0.91373147
92MP0002063_abnormal_learning/memory/cond0.87384559
93MP0000569_abnormal_digit_pigmentation0.85985853
94MP0003122_maternal_imprinting0.83757322
95MP0000026_abnormal_inner_ear0.83425899
96MP0004145_abnormal_muscle_electrophysio0.80997444
97MP0002733_abnormal_thermal_nociception0.80894286
98MP0006072_abnormal_retinal_apoptosis0.80548775
99MP0000579_abnormal_nail_morphology0.79059732
100MP0003633_abnormal_nervous_system0.78096220
101MP0000467_abnormal_esophagus_morphology0.77564065
102MP0002152_abnormal_brain_morphology0.75961336
103MP0001986_abnormal_taste_sensitivity0.75190953
104MP0003045_fibrosis0.73921760
105MP0002638_abnormal_pupillary_reflex0.71216306
106MP0004133_heterotaxia0.70065831
107MP0005253_abnormal_eye_physiology0.67450883
108MP0002069_abnormal_eating/drinking_beha0.64934320
109MP0001177_atelectasis0.63407180
110MP0002938_white_spotting0.62314409
111MP0004036_abnormal_muscle_relaxation0.61224322
112MP0001340_abnormal_eyelid_morphology0.60857016
113MP0005535_abnormal_body_temperature0.59633283
114MP0002735_abnormal_chemical_nociception0.58776178
115MP0003137_abnormal_impulse_conducting0.58398751
116MP0008872_abnormal_physiological_respon0.57529479
117MP0010386_abnormal_urinary_bladder0.57008475
118MP0008877_abnormal_DNA_methylation0.56644265
119MP0010769_abnormal_survival0.56130497
120MP0004130_abnormal_muscle_cell0.55616493
121MP0002184_abnormal_innervation0.54225451
122MP0002909_abnormal_adrenal_gland0.53240119
123MP0000372_irregular_coat_pigmentation0.53208711
124MP0010768_mortality/aging0.52285776
125MP0010770_preweaning_lethality0.51808207
126MP0002082_postnatal_lethality0.51808207
127MP0002933_joint_inflammation0.50860204
128MP0005388_respiratory_system_phenotype0.50604566
129MP0002133_abnormal_respiratory_system0.50604566
130MP0002090_abnormal_vision0.49807681
131MP0001968_abnormal_touch/_nociception0.49805634
132MP0000631_abnormal_neuroendocrine_gland0.49793852
133MP0001943_abnormal_respiration0.47247317
134MP0003183_abnormal_peptide_metabolism0.46616499
135MP0005645_abnormal_hypothalamus_physiol0.45705710
136MP0005166_decreased_susceptibility_to0.45302244
137MP0003956_abnormal_body_size0.45295934
138MP0003172_abnormal_lysosome_physiology0.44846814
139MP0002089_abnormal_postnatal_growth/wei0.42288152
140MP0003861_abnormal_nervous_system0.41817319

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.69741774
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.69741774
3Focal motor seizures (HP:0011153)6.63249204
4Neurofibrillary tangles (HP:0002185)6.15521277
5Sensory axonal neuropathy (HP:0003390)5.71634162
6Action tremor (HP:0002345)5.53627901
7Parakeratosis (HP:0001036)5.52041382
8Focal seizures (HP:0007359)5.43693586
9Abnormality of the corticospinal tract (HP:0002492)4.91049547
10Febrile seizures (HP:0002373)4.78014934
11Epileptic encephalopathy (HP:0200134)4.72347684
12Diplopia (HP:0000651)4.58109878
13Abnormality of binocular vision (HP:0011514)4.58109878
14Cerebral inclusion bodies (HP:0100314)4.33327797
15Peripheral hypomyelination (HP:0007182)4.30464056
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.28293107
17Cerebral hypomyelination (HP:0006808)3.95931700
18Spastic gait (HP:0002064)3.57757484
19Postural instability (HP:0002172)3.55743210
20Generalized tonic-clonic seizures (HP:0002069)3.55635354
21Alacrima (HP:0000522)3.48146067
22Supranuclear gaze palsy (HP:0000605)3.47531742
23Onion bulb formation (HP:0003383)3.45061870
24Abnormal eating behavior (HP:0100738)3.42768418
25Urinary bladder sphincter dysfunction (HP:0002839)3.42358851
26Papilledema (HP:0001085)3.36331205
27Akinesia (HP:0002304)3.35761109
28Progressive cerebellar ataxia (HP:0002073)3.34291192
29Increased serum pyruvate (HP:0003542)3.31857772
30Abnormality of glycolysis (HP:0004366)3.31857772
31Visual hallucinations (HP:0002367)3.28159488
32Urinary urgency (HP:0000012)3.21115534
33Absence seizures (HP:0002121)3.18340782
34Intention tremor (HP:0002080)3.16852092
35Abnormal auditory evoked potentials (HP:0006958)3.16096289
36Dialeptic seizures (HP:0011146)3.10971834
37Congenital ichthyosiform erythroderma (HP:0007431)3.08063497
38Obstructive sleep apnea (HP:0002870)3.07264054
39Impaired vibration sensation in the lower limbs (HP:0002166)3.07247811
40Spastic paraparesis (HP:0002313)3.03169206
41Truncal ataxia (HP:0002078)2.98540599
42Hemiplegia (HP:0002301)2.98354199
43Dysmetria (HP:0001310)2.97494260
44Thickened helices (HP:0000391)2.95113482
45Leukodystrophy (HP:0002415)2.92532766
46Anteriorly placed anus (HP:0001545)2.84944195
47Torticollis (HP:0000473)2.84236402
48Neuronal loss in central nervous system (HP:0002529)2.83041829
49Mutism (HP:0002300)2.77317903
50Autoamputation (HP:0001218)2.74468077
51Clonus (HP:0002169)2.73337183
52Dysdiadochokinesis (HP:0002075)2.73234265
53Tetraplegia (HP:0002445)2.73018541
54Limb dystonia (HP:0002451)2.71717427
55Premature skin wrinkling (HP:0100678)2.71666695
56Decreased lacrimation (HP:0000633)2.71170456
57Slow saccadic eye movements (HP:0000514)2.71092596
58Hypoplastic pelvis (HP:0008839)2.69538742
59Choreoathetosis (HP:0001266)2.68418299
60Bundle branch block (HP:0011710)2.65888823
61Absent septum pellucidum (HP:0001331)2.64327305
62Stridor (HP:0010307)2.63588457
63Insidious onset (HP:0003587)2.60978272
64Termporal pattern (HP:0011008)2.60978272
65Morphological abnormality of the pyramidal tract (HP:0002062)2.59821111
66Depression (HP:0000716)2.58469807
67Bradykinesia (HP:0002067)2.56577576
68Renal Fanconi syndrome (HP:0001994)2.55819811
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.55156805
70Status epilepticus (HP:0002133)2.55128922
71Delusions (HP:0000746)2.54761973
72Apathy (HP:0000741)2.51426654
73Myokymia (HP:0002411)2.50946222
74Epileptiform EEG discharges (HP:0011182)2.50184302
75Annular pancreas (HP:0001734)2.48559445
76Poor eye contact (HP:0000817)2.47480300
77Cerebral hemorrhage (HP:0001342)2.47345024
78Scanning speech (HP:0002168)2.46165030
79Infantile muscular hypotonia (HP:0008947)2.44508255
80Split foot (HP:0001839)2.43417721
81Hemiparesis (HP:0001269)2.41919265
82Rigidity (HP:0002063)2.39381085
83Sleep apnea (HP:0010535)2.39270905
84Hepatosplenomegaly (HP:0001433)2.37699284
85Retinal dysplasia (HP:0007973)2.36942252
86CNS hypomyelination (HP:0003429)2.35899799
87Anxiety (HP:0000739)2.33678463
88Focal dystonia (HP:0004373)2.31777673
89Rapidly progressive (HP:0003678)2.29222829
90Insomnia (HP:0100785)2.29153690
91Partial agenesis of the corpus callosum (HP:0001338)2.28832257
92Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.26919392
93Abnormality of the septum pellucidum (HP:0007375)2.26630876
94Abnormality of the phalanges of the 2nd finger (HP:0009541)2.26180784
95Clumsiness (HP:0002312)2.26082405
96Coronal craniosynostosis (HP:0004440)2.25889164
97Diminished motivation (HP:0000745)2.22528356
98Impaired vibratory sensation (HP:0002495)2.21017863
99Muscle fiber splitting (HP:0003555)2.20403709
100Humeroradial synostosis (HP:0003041)2.15776470
101Synostosis involving the elbow (HP:0003938)2.15776470
102Increased circulating renin level (HP:0000848)2.14603922
103Craniofacial dystonia (HP:0012179)2.14584050
104Spastic paraplegia (HP:0001258)2.14462714
105EEG with generalized epileptiform discharges (HP:0011198)2.13648951
106Erythroderma (HP:0001019)2.13614070
107Cupped ear (HP:0000378)2.12635556
108Impaired smooth pursuit (HP:0007772)2.12231814
109White forelock (HP:0002211)2.10089449
110Broad-based gait (HP:0002136)2.09980557
111Morphological abnormality of the inner ear (HP:0011390)2.09907053
112Partial duplication of thumb phalanx (HP:0009944)2.09384359
113Hypomagnesemia (HP:0002917)2.07682838
114Paraplegia (HP:0010550)2.07433336
115Patchy hypopigmentation of hair (HP:0011365)2.06448951
116Impaired social interactions (HP:0000735)2.06082213
117Abnormal social behavior (HP:0012433)2.06082213
118Abnormality of the periventricular white matter (HP:0002518)2.04823472
119Adrenal hypoplasia (HP:0000835)2.04089764
120Megalencephaly (HP:0001355)2.04049901
121Ankle clonus (HP:0011448)2.03596056
122Aplasia involving bones of the upper limbs (HP:0009823)1.99633574
123Aplasia of the phalanges of the hand (HP:0009802)1.99633574
124Aplasia involving bones of the extremities (HP:0009825)1.99633574
1253-Methylglutaconic aciduria (HP:0003535)1.99024638
126Gaze-evoked nystagmus (HP:0000640)1.98063330
127Abnormality of the lower motor neuron (HP:0002366)1.95945747
128Metabolic alkalosis (HP:0200114)1.95708915
129Methylmalonic acidemia (HP:0002912)1.95682907
130Paraparesis (HP:0002385)1.95427384
131Hypsarrhythmia (HP:0002521)1.94897249
132Abnormality of saccadic eye movements (HP:0000570)1.94609710
133Bronchomalacia (HP:0002780)1.94347082
134Abnormality of ocular smooth pursuit (HP:0000617)1.93767758
135Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.93438027
136Memory impairment (HP:0002354)1.92267091
137Hypoplasia of the iris (HP:0007676)1.90859480
138Lower limb muscle weakness (HP:0007340)1.90642938
139Barrel-shaped chest (HP:0001552)1.90252159
140Hyporeflexia of lower limbs (HP:0002600)1.90098136
141Foot dorsiflexor weakness (HP:0009027)1.89804219
142Pheochromocytoma (HP:0002666)1.89107876
143Spastic tetraparesis (HP:0001285)1.87218480
144Stenosis of the external auditory canal (HP:0000402)1.87216296
145Bowel incontinence (HP:0002607)1.84898117
146Poor speech (HP:0002465)1.83917740
147Diminished movement (HP:0002374)1.82241128
148Segmental peripheral demyelination/remyelination (HP:0003481)1.81271286
149Hypokalemic alkalosis (HP:0001949)1.80985970
150Atonic seizures (HP:0010819)1.79255047
151Partial duplication of the phalanx of hand (HP:0009999)1.77672040
152Increased hepatocellular lipid droplets (HP:0006565)1.77169000
153Urinary incontinence (HP:0000020)1.76629733
154Generalized myoclonic seizures (HP:0002123)1.76408220
155Esophageal atresia (HP:0002032)1.76125456
156Abolished electroretinogram (ERG) (HP:0000550)1.76106102
157Prolonged neonatal jaundice (HP:0006579)1.75350506
158Decreased motor nerve conduction velocity (HP:0003431)1.74547418
159Vaginal atresia (HP:0000148)1.73731505
160Septo-optic dysplasia (HP:0100842)1.71868674
161Abnormal large intestine physiology (HP:0012700)1.71603411
162Myelomeningocele (HP:0002475)1.70860948
163Abnormality of the foot musculature (HP:0001436)1.68871203
164Neuroendocrine neoplasm (HP:0100634)1.67964419
165Gowers sign (HP:0003391)1.67122372
166Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66585329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.46570927
2OXSR14.92794693
3NTRK34.26813603
4DAPK23.22269585
5CDK193.18107228
6BCR3.17662484
7EPHB12.76843659
8MET2.62660504
9WNK42.58274249
10PBK2.55516057
11MINK12.51050172
12PKN12.46955945
13PRPF4B2.29267194
14TNIK2.26847013
15LIMK12.26313364
16MAP3K92.22197181
17FGFR22.22085242
18PRKD32.21187317
19CAMKK12.16721034
20CSNK1G32.15223796
21CSNK1A1L2.08420424
22WNK12.05106820
23ICK2.03259599
24NEK62.02471127
25RIPK41.91911987
26CSNK1G11.70369784
27TESK21.63910948
28CSNK1G21.58924702
29UHMK11.56829587
30PNCK1.55057985
31PLK21.54332601
32CAMK2B1.53738152
33MST41.51399376
34ROCK21.49023309
35FGR1.44865616
36CAMK11.36412366
37PAK61.35781981
38NTRK11.35301148
39CAMK2D1.32029980
40MAPKAPK51.31221653
41PINK11.30493039
42GRK51.28417718
43LATS21.27903478
44CLK11.25412459
45EPHA41.20075745
46DAPK11.18402497
47MAPK131.17663540
48ALK1.14454088
49RIPK11.13399401
50SGK21.12366573
51BMPR21.08843668
52PRKCG1.07566715
53ARAF1.03415415
54CASK1.02765546
55CAMK2G1.00056785
56SGK10.98615708
57SGK30.98265599
58TRPM70.95586935
59CDK140.93606923
60ERBB40.93096249
61CAMKK20.89111058
62PRKCQ0.85802320
63MAPK150.84104479
64MAPK120.83657908
65BMPR1B0.83379398
66DYRK20.83134198
67STK380.82434912
68CDK150.81277440
69MARK10.80261729
70SIK20.80212261
71CDK50.78446793
72CDK180.75779129
73PAK30.75364569
74MAP3K130.75270485
75CAMK2A0.73986698
76CDK11A0.73766403
77SGK4940.73630138
78SGK2230.73630138
79MARK20.73329233
80TYRO30.70541234
81RPS6KA30.69780653
82CAMK40.63180890
83MAP3K40.62992668
84PDPK10.62381597
85BRSK10.58721225
86FYN0.58676369
87MAP3K110.58588595
88PHKG10.55724283
89PHKG20.55724283
90PRKD10.55258876
91MUSK0.54742563
92KSR10.52351576
93CSNK1D0.52131703
94PRKCE0.51474990
95IRAK20.51467131
96MAP3K20.51402284
97TNK20.51268165
98ITK0.50934431
99MAP2K40.50924585
100RET0.49326224
101PRKCH0.49315512
102RPS6KA50.48933220
103PRKCZ0.47732030
104BRAF0.46572978
105FES0.45995197
106DAPK30.45939618
107PRKG10.45838192
108MAP3K10.42685932
109STK110.41917436
110RAF10.41216150
111PAK10.40408350
112CSNK1A10.39503588
113ROCK10.36345012
114PRKACB0.36145577
115PRKCA0.35122855
116PRKCB0.34003447
117JAK20.33277075
118STK160.33135371
119MAPK70.32972916
120PIK3CA0.32170623
121ADRBK20.31592917
122KSR20.31322614
123MAP3K120.30882722
124GSK3B0.30843573
125LMTK20.30712926
126OBSCN0.30482815
127BMX0.30276923
128GSK3A0.29204716
129MOS0.28969573
130PTK2B0.28594863
131GRK70.28418547
132PDGFRB0.28137009
133MAP2K20.26735351
134INSR0.26152546
135PDK10.25577233
136NME10.23635562
137DMPK0.23510477
138CSK0.22609102
139NUAK10.22367010
140CAMK1G0.21928253
141PRKACA0.21380599
142CSNK1E0.20919045
143DYRK1A0.20580981
144ABL10.19885277
145NTRK20.19668615
146LCK0.19619938
147MAPK100.18726721
148DDR20.18552100

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.10989343
2Steroid biosynthesis_Homo sapiens_hsa001004.63240849
3Fatty acid elongation_Homo sapiens_hsa000624.44375778
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.47503057
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.41165053
6Ether lipid metabolism_Homo sapiens_hsa005653.03878233
7Long-term potentiation_Homo sapiens_hsa047202.96804894
8Amphetamine addiction_Homo sapiens_hsa050312.65135914
9Oxidative phosphorylation_Homo sapiens_hsa001902.58543516
10Protein export_Homo sapiens_hsa030602.54565671
11Insulin secretion_Homo sapiens_hsa049112.46655939
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.43918508
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33236416
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.21196446
15Sulfur metabolism_Homo sapiens_hsa009202.16917031
16Sphingolipid metabolism_Homo sapiens_hsa006001.97434178
17Axon guidance_Homo sapiens_hsa043601.97348736
18Vitamin B6 metabolism_Homo sapiens_hsa007501.87805696
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79211788
20Parkinsons disease_Homo sapiens_hsa050121.75921364
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72346164
22Linoleic acid metabolism_Homo sapiens_hsa005911.72121748
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70185588
24Alzheimers disease_Homo sapiens_hsa050101.66032491
25Renin secretion_Homo sapiens_hsa049241.65340819
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60847915
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55757946
28Histidine metabolism_Homo sapiens_hsa003401.54937960
29Oxytocin signaling pathway_Homo sapiens_hsa049211.49379396
30Butanoate metabolism_Homo sapiens_hsa006501.48598334
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48034757
32Calcium signaling pathway_Homo sapiens_hsa040201.47524347
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46907461
34cAMP signaling pathway_Homo sapiens_hsa040241.46467273
35Taste transduction_Homo sapiens_hsa047421.42874667
36Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.42601249
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33343400
38Arginine and proline metabolism_Homo sapiens_hsa003301.26094386
39Estrogen signaling pathway_Homo sapiens_hsa049151.24827415
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24387327
41GnRH signaling pathway_Homo sapiens_hsa049121.22475910
42Bile secretion_Homo sapiens_hsa049761.20364088
43Gap junction_Homo sapiens_hsa045401.18089701
44Olfactory transduction_Homo sapiens_hsa047401.13203864
45Vibrio cholerae infection_Homo sapiens_hsa051101.09895023
46Serotonergic synapse_Homo sapiens_hsa047261.09375200
47Renal cell carcinoma_Homo sapiens_hsa052111.09069794
48Glioma_Homo sapiens_hsa052141.08982335
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07142394
50Glutathione metabolism_Homo sapiens_hsa004801.06095282
51beta-Alanine metabolism_Homo sapiens_hsa004101.05996237
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05351830
53Collecting duct acid secretion_Homo sapiens_hsa049661.04476612
54Arachidonic acid metabolism_Homo sapiens_hsa005901.02835210
55SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02732838
56GABAergic synapse_Homo sapiens_hsa047271.01635842
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98282759
58Tight junction_Homo sapiens_hsa045300.97240222
59Huntingtons disease_Homo sapiens_hsa050160.96592487
60Cardiac muscle contraction_Homo sapiens_hsa042600.96351670
61Glutamatergic synapse_Homo sapiens_hsa047240.94864348
62Autoimmune thyroid disease_Homo sapiens_hsa053200.94745443
63Rheumatoid arthritis_Homo sapiens_hsa053230.94522363
64Melanogenesis_Homo sapiens_hsa049160.91458621
65Thyroid hormone synthesis_Homo sapiens_hsa049180.90802219
66Rap1 signaling pathway_Homo sapiens_hsa040150.89913152
67Inositol phosphate metabolism_Homo sapiens_hsa005620.89037108
68Prion diseases_Homo sapiens_hsa050200.86520421
69Oocyte meiosis_Homo sapiens_hsa041140.86384818
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85813770
71Malaria_Homo sapiens_hsa051440.84131206
72Morphine addiction_Homo sapiens_hsa050320.80582561
73Long-term depression_Homo sapiens_hsa047300.78265194
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.78008438
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.77964108
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77000162
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.76205090
78Endocytosis_Homo sapiens_hsa041440.75374868
79MAPK signaling pathway_Homo sapiens_hsa040100.75193439
80Fatty acid metabolism_Homo sapiens_hsa012120.73998290
81Folate biosynthesis_Homo sapiens_hsa007900.73919825
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72696331
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72172473
84Phototransduction_Homo sapiens_hsa047440.71615646
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70151448
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68754255
87Lysosome_Homo sapiens_hsa041420.68435508
88Ovarian steroidogenesis_Homo sapiens_hsa049130.65735765
89Ras signaling pathway_Homo sapiens_hsa040140.64362608
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.62401128
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.62334570
92Propanoate metabolism_Homo sapiens_hsa006400.61810760
93VEGF signaling pathway_Homo sapiens_hsa043700.61503497
94Type II diabetes mellitus_Homo sapiens_hsa049300.61397563
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59890084
96Peroxisome_Homo sapiens_hsa041460.59594357
97Choline metabolism in cancer_Homo sapiens_hsa052310.58563138
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.58409952
99ErbB signaling pathway_Homo sapiens_hsa040120.55954769
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55424085
101Phagosome_Homo sapiens_hsa041450.54947319
102Cocaine addiction_Homo sapiens_hsa050300.54516313
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54382921
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52475148
105Metabolic pathways_Homo sapiens_hsa011000.52087530
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51880406
107Chemical carcinogenesis_Homo sapiens_hsa052040.50484123
108ECM-receptor interaction_Homo sapiens_hsa045120.50007157
109Circadian rhythm_Homo sapiens_hsa047100.48246231
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47402691
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46272123
112Glucagon signaling pathway_Homo sapiens_hsa049220.45494635
113Mineral absorption_Homo sapiens_hsa049780.44527179
114Hedgehog signaling pathway_Homo sapiens_hsa043400.44279325
115Arginine biosynthesis_Homo sapiens_hsa002200.43456647
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43113084
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42145380
118Dorso-ventral axis formation_Homo sapiens_hsa043200.41362617
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40926257
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40254875
121Dilated cardiomyopathy_Homo sapiens_hsa054140.40176270
122Nicotine addiction_Homo sapiens_hsa050330.38129036
123Circadian entrainment_Homo sapiens_hsa047130.38085735
124Salivary secretion_Homo sapiens_hsa049700.37927345
125Retinol metabolism_Homo sapiens_hsa008300.37426654
126ABC transporters_Homo sapiens_hsa020100.36522661
127Tyrosine metabolism_Homo sapiens_hsa003500.35116334
128Regulation of autophagy_Homo sapiens_hsa041400.34742157
129Fatty acid biosynthesis_Homo sapiens_hsa000610.34123138
130Wnt signaling pathway_Homo sapiens_hsa043100.33576264
131Pancreatic secretion_Homo sapiens_hsa049720.33516204
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32091261
133mTOR signaling pathway_Homo sapiens_hsa041500.31078050
134Basal transcription factors_Homo sapiens_hsa030220.30292216
135Synaptic vesicle cycle_Homo sapiens_hsa047210.27586204
136Endometrial cancer_Homo sapiens_hsa052130.27304047
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26856538
138Vitamin digestion and absorption_Homo sapiens_hsa049770.26630899
139Hippo signaling pathway_Homo sapiens_hsa043900.26540203
140Nitrogen metabolism_Homo sapiens_hsa009100.25331456
141Cholinergic synapse_Homo sapiens_hsa047250.25067835
142Dopaminergic synapse_Homo sapiens_hsa047280.24641190
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24381319
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24166257
145Asthma_Homo sapiens_hsa053100.23147102
146Alcoholism_Homo sapiens_hsa050340.21425306
147Salmonella infection_Homo sapiens_hsa051320.21040352
148Glycerolipid metabolism_Homo sapiens_hsa005610.20178471
149Gastric acid secretion_Homo sapiens_hsa049710.20087458
150Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20031782
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17946665

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