OPHN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked mental retardation with cerebellar hypoplasia and distinctive facial dysmorhphism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.54721057
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.80156840
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.29069082
4tryptophan catabolic process (GO:0006569)4.27340246
5indole-containing compound catabolic process (GO:0042436)4.27340246
6indolalkylamine catabolic process (GO:0046218)4.27340246
7kynurenine metabolic process (GO:0070189)4.21063201
8regulation of glutamate receptor signaling pathway (GO:1900449)4.12947552
9locomotory exploration behavior (GO:0035641)4.09667000
10indolalkylamine metabolic process (GO:0006586)3.99758480
11ionotropic glutamate receptor signaling pathway (GO:0035235)3.95678260
12fucose catabolic process (GO:0019317)3.80980629
13L-fucose metabolic process (GO:0042354)3.80980629
14L-fucose catabolic process (GO:0042355)3.80980629
15neuron cell-cell adhesion (GO:0007158)3.76151243
16vocalization behavior (GO:0071625)3.74981391
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.72638333
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.69743821
19neuronal action potential (GO:0019228)3.57079758
20tryptophan metabolic process (GO:0006568)3.51818525
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.51683379
22glutamate receptor signaling pathway (GO:0007215)3.50001861
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.43494058
24serotonin metabolic process (GO:0042428)3.41427479
25cytoplasmic mRNA processing body assembly (GO:0033962)3.40217952
26response to auditory stimulus (GO:0010996)3.39982271
27synaptic transmission, glutamatergic (GO:0035249)3.39370361
28indole-containing compound metabolic process (GO:0042430)3.38648399
29neural tube formation (GO:0001841)3.38191765
30cilium or flagellum-dependent cell motility (GO:0001539)3.35930271
31protein localization to synapse (GO:0035418)3.35183515
32primary amino compound metabolic process (GO:1901160)3.34767129
33regulation of synapse structural plasticity (GO:0051823)3.30818200
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25459547
35kidney morphogenesis (GO:0060993)3.21117366
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20299552
37positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.19882169
38neurotransmitter-gated ion channel clustering (GO:0072578)3.19806931
39detection of light stimulus involved in visual perception (GO:0050908)3.19787525
40detection of light stimulus involved in sensory perception (GO:0050962)3.19787525
41regulation of hippo signaling (GO:0035330)3.18992453
42cerebellar Purkinje cell differentiation (GO:0021702)3.15386154
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.13088489
44synaptic vesicle maturation (GO:0016188)3.13006435
45sulfation (GO:0051923)3.12702698
46neuron recognition (GO:0008038)3.12405544
47cellular ketone body metabolic process (GO:0046950)3.10578359
48reflex (GO:0060004)3.09575878
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.09520624
50microglial cell activation (GO:0001774)3.08845882
51synaptic vesicle exocytosis (GO:0016079)3.07560320
52regulation of synaptic vesicle transport (GO:1902803)3.07537131
53glutamate secretion (GO:0014047)3.06409347
54dendrite morphogenesis (GO:0048813)3.05907275
55nonmotile primary cilium assembly (GO:0035058)3.05109085
56* synaptic vesicle endocytosis (GO:0048488)3.02706618
57exploration behavior (GO:0035640)3.00012282
58regulation of posttranscriptional gene silencing (GO:0060147)2.99748493
59regulation of gene silencing by miRNA (GO:0060964)2.99748493
60regulation of gene silencing by RNA (GO:0060966)2.99748493
61postsynaptic membrane organization (GO:0001941)2.99333791
62startle response (GO:0001964)2.97874181
63regulation of synaptic vesicle exocytosis (GO:2000300)2.97662190
64nephron epithelium morphogenesis (GO:0072088)2.96954150
65nephron tubule morphogenesis (GO:0072078)2.96954150
66regulation of neuronal synaptic plasticity (GO:0048168)2.96736290
67neuron-neuron synaptic transmission (GO:0007270)2.96714929
68axonal fasciculation (GO:0007413)2.96616203
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95569025
70neuronal action potential propagation (GO:0019227)2.95536258
71positive regulation of sodium ion transmembrane transport (GO:1902307)2.95440349
72synaptic vesicle docking involved in exocytosis (GO:0016081)2.93983303
73proline transport (GO:0015824)2.93549610
74central nervous system myelination (GO:0022010)2.92488662
75axon ensheathment in central nervous system (GO:0032291)2.92488662
76presynaptic membrane assembly (GO:0097105)2.90397159
77regulation of synapse maturation (GO:0090128)2.90250556
78peristalsis (GO:0030432)2.89831067
79spinal cord motor neuron differentiation (GO:0021522)2.88122805
80layer formation in cerebral cortex (GO:0021819)2.86900587
81negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.83649119
82negative regulation of translation, ncRNA-mediated (GO:0040033)2.83649119
83regulation of translation, ncRNA-mediated (GO:0045974)2.83649119
84cellular potassium ion homeostasis (GO:0030007)2.81979566
85membrane depolarization during action potential (GO:0086010)2.81627628
86positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.80441771
87auditory behavior (GO:0031223)2.79585954
88regulation of excitatory postsynaptic membrane potential (GO:0060079)2.79109019
89* regulation of synaptic transmission, glutamatergic (GO:0051966)2.78313758
90cell morphogenesis involved in neuron differentiation (GO:0048667)2.78127972
91epithelial cilium movement (GO:0003351)2.77867353
92cerebral cortex radially oriented cell migration (GO:0021799)2.77834119
93NAD biosynthetic process (GO:0009435)2.77513008
94ketone body metabolic process (GO:1902224)2.77205934
95positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.76892925
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76047601
97positive regulation of CREB transcription factor activity (GO:0032793)2.75279230
98urinary tract smooth muscle contraction (GO:0014848)2.75080212
99cilium movement (GO:0003341)2.73701791
100dendritic spine morphogenesis (GO:0060997)2.73595876
101transmission of nerve impulse (GO:0019226)2.72928263
102cellular biogenic amine catabolic process (GO:0042402)2.71513534
103amine catabolic process (GO:0009310)2.71513534
104G-protein coupled receptor internalization (GO:0002031)2.70626145
105cornea development in camera-type eye (GO:0061303)2.69950555
106regulation of postsynaptic membrane potential (GO:0060078)2.69516123
107L-amino acid import (GO:0043092)2.69261342
108neurotransmitter secretion (GO:0007269)2.69092939
109inner ear receptor stereocilium organization (GO:0060122)2.68984138
110positive regulation of synapse maturation (GO:0090129)2.68486921
111long-term synaptic potentiation (GO:0060291)2.68331402
112long-term memory (GO:0007616)2.67935604
113negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.67857817
114negative regulation of cytosolic calcium ion concentration (GO:0051481)2.67472012
115gamma-aminobutyric acid signaling pathway (GO:0007214)2.66336919
116presynaptic membrane organization (GO:0097090)2.65934908
117signal peptide processing (GO:0006465)2.65847147
118regulation of action potential (GO:0098900)2.65514436
119negative regulation of mast cell activation (GO:0033004)2.64725934
120regulation of neurotransmitter secretion (GO:0046928)2.64503883
121cilium organization (GO:0044782)2.64302572
122membrane depolarization (GO:0051899)2.63146906
123interkinetic nuclear migration (GO:0022027)2.62003305
124action potential (GO:0001508)2.60988988
125cellular response to sterol (GO:0036315)2.60732944
126protein import into peroxisome matrix (GO:0016558)2.59712555
127atrial cardiac muscle cell action potential (GO:0086014)2.59297131
128cilium assembly (GO:0042384)2.57934443
129regulation of synaptic transmission, GABAergic (GO:0032228)2.56999526
130cAMP catabolic process (GO:0006198)2.55870355
131gamma-aminobutyric acid transport (GO:0015812)2.53906559
132amino acid import (GO:0043090)2.52667420
133central nervous system projection neuron axonogenesis (GO:0021952)2.51882239
134retinal cone cell development (GO:0046549)2.51453366
135innervation (GO:0060384)2.50535780
136negative regulation of sodium ion transport (GO:0010766)2.50146569
137response to pheromone (GO:0019236)2.49935627
138glycine transport (GO:0015816)2.49706385
139regulation of synaptic plasticity (GO:0048167)2.49563060
140renal tubule morphogenesis (GO:0061333)2.49238015
141positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.48760920
142regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.48760920
143auditory receptor cell stereocilium organization (GO:0060088)2.48717226
144benzene-containing compound metabolic process (GO:0042537)2.48646376
145cilium morphogenesis (GO:0060271)2.48409620
146neurotransmitter metabolic process (GO:0042133)2.48121647
147regulation of respiratory system process (GO:0044065)2.47621888
148oxidative demethylation (GO:0070989)2.47387935
149cardiovascular system development (GO:0072358)2.47249333
150detection of mechanical stimulus involved in sensory perception (GO:0050974)2.46813637
151phasic smooth muscle contraction (GO:0014821)2.46538982
152cell differentiation in spinal cord (GO:0021515)2.46382644
153cerebellar granule cell differentiation (GO:0021707)2.46235922
154pyrimidine nucleobase catabolic process (GO:0006208)2.46222465
155somite rostral/caudal axis specification (GO:0032525)2.45119007
156negative regulation of systemic arterial blood pressure (GO:0003085)2.44987675
157synapse assembly (GO:0007416)2.44828058
158neuromuscular process controlling balance (GO:0050885)2.44771459
159negative regulation of dendrite development (GO:2000171)2.44706239
160regulation of dendritic spine morphogenesis (GO:0061001)2.44112131
161activation of protein kinase A activity (GO:0034199)2.43863901
162phosphatidylinositol acyl-chain remodeling (GO:0036149)2.43491775
163neuronal stem cell maintenance (GO:0097150)2.42513593
164rRNA catabolic process (GO:0016075)2.41924347
165regulation of dendritic spine development (GO:0060998)2.41433266
166behavioral defense response (GO:0002209)2.41372334
167behavioral fear response (GO:0001662)2.41372334
168N-glycan processing (GO:0006491)2.39471142
169negative regulation of synaptic transmission, GABAergic (GO:0032229)2.37025631
170chondroitin sulfate catabolic process (GO:0030207)2.36266882
171adult walking behavior (GO:0007628)2.35453081
172axon extension (GO:0048675)2.35103686
173regulation of neurotransmitter transport (GO:0051588)2.34347418
174membrane hyperpolarization (GO:0060081)2.34328611
175positive regulation of synaptic transmission (GO:0050806)2.33688300
176fear response (GO:0042596)2.33190615
177regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.33106837
178neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.30677957
179neurotransmitter transport (GO:0006836)2.30575344
180neuronal ion channel clustering (GO:0045161)2.29320267
181learning (GO:0007612)2.29225344
182behavioral response to ethanol (GO:0048149)2.29021459
183positive regulation of dendritic spine development (GO:0060999)2.28317993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.50670623
2GBX2_23144817_ChIP-Seq_PC3_Human3.72563662
3ZNF274_21170338_ChIP-Seq_K562_Hela3.61121710
4VDR_22108803_ChIP-Seq_LS180_Human2.94082651
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54450109
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50448374
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47927830
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33189365
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26872038
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25312253
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25312253
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.20400505
13DROSHA_22980978_ChIP-Seq_HELA_Human2.17261415
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15874753
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09205160
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.06813883
17AR_21572438_ChIP-Seq_LNCaP_Human2.06014789
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05727778
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05275039
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94078782
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.91075451
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.85695487
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84419106
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84148206
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.84049118
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82526682
27REST_21632747_ChIP-Seq_MESCs_Mouse1.80271203
28EWS_26573619_Chip-Seq_HEK293_Human1.79655299
29FUS_26573619_Chip-Seq_HEK293_Human1.76499245
30SMAD4_21799915_ChIP-Seq_A2780_Human1.70758896
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.67228453
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65816249
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65502914
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63675211
35AHR_22903824_ChIP-Seq_MCF-7_Human1.59874750
36P300_19829295_ChIP-Seq_ESCs_Human1.59479698
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.58621172
38ARNT_22903824_ChIP-Seq_MCF-7_Human1.57523563
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57482910
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55081299
41TAF15_26573619_Chip-Seq_HEK293_Human1.54282839
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52932983
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50941224
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49342396
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46713679
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.44984878
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.44821289
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43599451
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41844275
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40381250
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40081790
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39909600
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.39787049
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39685044
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39678299
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38975835
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38060266
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37869682
59STAT3_23295773_ChIP-Seq_U87_Human1.36664215
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34309210
61AR_25329375_ChIP-Seq_VCAP_Human1.34116793
62* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31253482
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.29709863
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29246974
65IGF1R_20145208_ChIP-Seq_DFB_Human1.28894056
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28290750
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28290750
68CBP_20019798_ChIP-Seq_JUKART_Human1.27969610
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27969610
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.27934649
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.25276044
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25210251
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24842252
74TP53_16413492_ChIP-PET_HCT116_Human1.24718551
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23578544
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23355481
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21300403
78TCF4_22108803_ChIP-Seq_LS180_Human1.20526977
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20431298
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18616511
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.18526038
82* TCF4_23295773_ChIP-Seq_U87_Human1.17725025
83BCAT_22108803_ChIP-Seq_LS180_Human1.17021243
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16656048
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.15911600
86TP53_22573176_ChIP-Seq_HFKS_Human1.14719694
87TP53_18474530_ChIP-ChIP_U2OS_Human1.14508388
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14429537
89* AR_19668381_ChIP-Seq_PC3_Human1.14307190
90* RUNX2_22187159_ChIP-Seq_PCA_Human1.14304540
91SMAD4_21741376_ChIP-Seq_EPCs_Human1.13789172
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13136913
93RNF2_27304074_Chip-Seq_NSC_Mouse1.12054149
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11982863
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11785785
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10783731
97SOX2_19829295_ChIP-Seq_ESCs_Human1.10772599
98NANOG_19829295_ChIP-Seq_ESCs_Human1.10772599
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09199359
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07812426
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07615108
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06301901
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.06235888
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05752808
105NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05172412
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05117582
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.04671985
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04668865
109FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04578966
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.03584450
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.03583316
112FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03583316
113ER_23166858_ChIP-Seq_MCF-7_Human1.03298282
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03283182
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.02801720
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02705656
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02677531
118IRF1_19129219_ChIP-ChIP_H3396_Human1.02492754
119RXR_22108803_ChIP-Seq_LS180_Human1.02365676
120KDM2B_26808549_Chip-Seq_REH_Human1.01905303
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01667196
122SMAD3_21741376_ChIP-Seq_ESCs_Human1.01588866
123SMAD4_21741376_ChIP-Seq_HESCs_Human1.00552814
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00388347
125EP300_21415370_ChIP-Seq_HL-1_Mouse1.00027083
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99649167
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.98840718
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.97908791
129CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96509578
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96264676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.20163201
2MP0003880_abnormal_central_pattern3.46855707
3* MP0003635_abnormal_synaptic_transmissio3.29340099
4MP0003136_yellow_coat_color3.18677128
5MP0001968_abnormal_touch/_nociception2.93742769
6* MP0002063_abnormal_learning/memory/cond2.69899503
7MP0009046_muscle_twitch2.68858107
8MP0009745_abnormal_behavioral_response2.64513488
9MP0002064_seizures2.61512426
10MP0004270_analgesia2.59065379
11MP0002736_abnormal_nociception_after2.58674602
12MP0003195_calcinosis2.56235639
13* MP0002572_abnormal_emotion/affect_behav2.47290995
14MP0001486_abnormal_startle_reflex2.46244992
15MP0002734_abnormal_mechanical_nocicepti2.25580130
16MP0005423_abnormal_somatic_nervous2.25146439
17MP0000778_abnormal_nervous_system2.21399247
18MP0004043_abnormal_pH_regulation2.20733127
19MP0002653_abnormal_ependyma_morphology2.13229012
20MP0003646_muscle_fatigue2.12360357
21MP0009780_abnormal_chondrocyte_physiolo2.08330121
22MP0000569_abnormal_digit_pigmentation2.06105450
23MP0002272_abnormal_nervous_system2.05271026
24MP0001984_abnormal_olfaction1.99555080
25MP0002067_abnormal_sensory_capabilities1.98345637
26MP0005645_abnormal_hypothalamus_physiol1.94524049
27MP0001440_abnormal_grooming_behavior1.94083873
28MP0003787_abnormal_imprinting1.93974701
29MP0001501_abnormal_sleep_pattern1.93463160
30MP0005646_abnormal_pituitary_gland1.83625343
31* MP0002557_abnormal_social/conspecific_i1.83250835
32MP0001188_hyperpigmentation1.81623943
33MP0002184_abnormal_innervation1.78539657
34MP0003283_abnormal_digestive_organ1.78114944
35MP0003890_abnormal_embryonic-extraembry1.74329844
36MP0004858_abnormal_nervous_system1.72974609
37MP0001970_abnormal_pain_threshold1.72942030
38MP0002735_abnormal_chemical_nociception1.72787758
39MP0002733_abnormal_thermal_nociception1.72361690
40MP0000427_abnormal_hair_cycle1.71623325
41MP0004133_heterotaxia1.69543520
42MP0008872_abnormal_physiological_respon1.68139639
43MP0008877_abnormal_DNA_methylation1.65368871
44MP0003183_abnormal_peptide_metabolism1.63342093
45MP0006276_abnormal_autonomic_nervous1.54668579
46MP0005670_abnormal_white_adipose1.54186977
47MP0006292_abnormal_olfactory_placode1.52415547
48MP0004885_abnormal_endolymph1.51978486
49MP0003690_abnormal_glial_cell1.51453576
50MP0000383_abnormal_hair_follicle1.50453554
51MP0002938_white_spotting1.49985072
52MP0005253_abnormal_eye_physiology1.44810668
53MP0008569_lethality_at_weaning1.41507626
54MP0005171_absent_coat_pigmentation1.39555514
55MP0008875_abnormal_xenobiotic_pharmacok1.38773783
56MP0005409_darkened_coat_color1.36064837
57MP0000516_abnormal_urinary_system1.35733078
58MP0005367_renal/urinary_system_phenotyp1.35733078
59MP0004811_abnormal_neuron_physiology1.33140380
60MP0002837_dystrophic_cardiac_calcinosis1.31433263
61MP0003172_abnormal_lysosome_physiology1.30747184
62MP0003633_abnormal_nervous_system1.29996426
63MP0002638_abnormal_pupillary_reflex1.28251202
64MP0001502_abnormal_circadian_rhythm1.28215191
65MP0003045_fibrosis1.26988299
66MP0002822_catalepsy1.26805993
67MP0005174_abnormal_tail_pigmentation1.23773189
68MP0001177_atelectasis1.22880200
69* MP0002882_abnormal_neuron_morphology1.22521954
70MP0008961_abnormal_basal_metabolism1.21162872
71MP0002928_abnormal_bile_duct1.20290206
72MP0003137_abnormal_impulse_conducting1.19183914
73MP0004742_abnormal_vestibular_system1.16578202
74* MP0005386_behavior/neurological_phenoty1.15971144
75* MP0004924_abnormal_behavior1.15971144
76MP0001986_abnormal_taste_sensitivity1.14420498
77* MP0002066_abnormal_motor_capabilities/c1.12875941
78MP0000955_abnormal_spinal_cord1.12865680
79MP0001529_abnormal_vocalization1.10816618
80MP0002909_abnormal_adrenal_gland1.09947461
81MP0003119_abnormal_digestive_system1.09640989
82MP0003878_abnormal_ear_physiology1.09563939
83MP0005377_hearing/vestibular/ear_phenot1.09563939
84MP0003634_abnormal_glial_cell1.09337416
85MP0006072_abnormal_retinal_apoptosis1.08819971
86MP0004484_altered_response_of1.08160460
87MP0005195_abnormal_posterior_eye1.05914318
88MP0004142_abnormal_muscle_tone1.05825531
89MP0001905_abnormal_dopamine_level1.04966175
90* MP0002152_abnormal_brain_morphology1.02554898
91MP0000230_abnormal_systemic_arterial1.01906760
92MP0001963_abnormal_hearing_physiology1.01827234
93MP0004145_abnormal_muscle_electrophysio1.01647473
94MP0000015_abnormal_ear_pigmentation0.99639582
95MP0003631_nervous_system_phenotype0.97586008
96MP0003011_delayed_dark_adaptation0.95569062
97MP0005187_abnormal_penis_morphology0.92862135
98MP0002090_abnormal_vision0.92377103
99MP0005394_taste/olfaction_phenotype0.91777712
100MP0005499_abnormal_olfactory_system0.91777712
101MP0001299_abnormal_eye_distance/0.89470632
102MP0002160_abnormal_reproductive_system0.88501540
103MP0000538_abnormal_urinary_bladder0.88451568
104MP0003122_maternal_imprinting0.87777897
105MP0000631_abnormal_neuroendocrine_gland0.86530410
106MP0005085_abnormal_gallbladder_physiolo0.84900289
107MP0003937_abnormal_limbs/digits/tail_de0.84356753
108MP0002751_abnormal_autonomic_nervous0.82809544
109MP0005257_abnormal_intraocular_pressure0.82740172
110MP0005448_abnormal_energy_balance0.82034670
111MP0000566_synostosis0.81568185
112MP0005167_abnormal_blood-brain_barrier0.81325566
113MP0002277_abnormal_respiratory_mucosa0.81304091
114MP0004130_abnormal_muscle_cell0.80911454
115MP0000647_abnormal_sebaceous_gland0.79923097
116MP0003959_abnormal_lean_body0.79816122
117MP0003252_abnormal_bile_duct0.79737897
118MP0002095_abnormal_skin_pigmentation0.79162884
119MP0002752_abnormal_somatic_nervous0.78957984
120MP0003638_abnormal_response/metabolism_0.78447628
121MP0003879_abnormal_hair_cell0.78196447
122MP0000026_abnormal_inner_ear0.77799257
123MP0004085_abnormal_heartbeat0.76452921
124MP0002069_abnormal_eating/drinking_beha0.76325060
125MP0008874_decreased_physiological_sensi0.76062111
126MP0002229_neurodegeneration0.73103378
127MP0002102_abnormal_ear_morphology0.72308772
128MP0005666_abnormal_adipose_tissue0.71182734
129MP0004215_abnormal_myocardial_fiber0.70423746
130MP0003632_abnormal_nervous_system0.69360117
131MP0000013_abnormal_adipose_tissue0.69090081
132MP0010386_abnormal_urinary_bladder0.68944874
133MP0000751_myopathy0.67262162
134MP0002876_abnormal_thyroid_physiology0.65852964
135MP0000920_abnormal_myelination0.63750125
136MP0005623_abnormal_meninges_morphology0.63012541
137* MP0003861_abnormal_nervous_system0.62704647
138MP0002234_abnormal_pharynx_morphology0.61916887
139MP0003938_abnormal_ear_development0.59448746
140MP0004147_increased_porphyrin_level0.59192939
141MP0001485_abnormal_pinna_reflex0.59032586
142MP0005551_abnormal_eye_electrophysiolog0.56480767

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.47391102
2Birth length less than 3rd percentile (HP:0003561)5.28306741
3Pancreatic cysts (HP:0001737)4.53279890
4True hermaphroditism (HP:0010459)4.34550284
5Pancreatic fibrosis (HP:0100732)4.26021070
6Febrile seizures (HP:0002373)4.22033282
7Abnormality of midbrain morphology (HP:0002418)4.10760811
8Molar tooth sign on MRI (HP:0002419)4.10760811
9Focal seizures (HP:0007359)4.01693079
10Epileptic encephalopathy (HP:0200134)3.78068330
11Congenital stationary night blindness (HP:0007642)3.65176931
12Supranuclear gaze palsy (HP:0000605)3.56809705
13Type II lissencephaly (HP:0007260)3.52018241
14Myokymia (HP:0002411)3.51077343
15Progressive cerebellar ataxia (HP:0002073)3.34258078
16Inability to walk (HP:0002540)3.29998681
17Action tremor (HP:0002345)3.29245330
18Atonic seizures (HP:0010819)3.27291945
19Patellar aplasia (HP:0006443)3.21736015
20Breast hypoplasia (HP:0003187)3.11079789
21Poor eye contact (HP:0000817)3.08712160
22Abnormality of the renal cortex (HP:0011035)3.07979718
23Abnormality of the renal medulla (HP:0100957)3.04695411
24Cystic liver disease (HP:0006706)3.04609546
25Large for gestational age (HP:0001520)3.04304597
26Broad-based gait (HP:0002136)3.03802320
27Aplasia/Hypoplasia of the patella (HP:0006498)2.98474978
28Postural instability (HP:0002172)2.97001272
29Drooling (HP:0002307)2.95704873
30Excessive salivation (HP:0003781)2.95704873
31Congenital, generalized hypertrichosis (HP:0004540)2.93746904
32Visual hallucinations (HP:0002367)2.93561746
33Progressive inability to walk (HP:0002505)2.90922841
34Mutism (HP:0002300)2.86875709
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.85027893
36Abnormality of alanine metabolism (HP:0010916)2.85027893
37Hyperalaninemia (HP:0003348)2.85027893
38Medial flaring of the eyebrow (HP:0010747)2.82444879
39Attenuation of retinal blood vessels (HP:0007843)2.82132398
40Chronic hepatic failure (HP:0100626)2.81501527
41Tubular atrophy (HP:0000092)2.78108212
42Hyperventilation (HP:0002883)2.73691152
43Arterial tortuosity (HP:0005116)2.69650499
44Furrowed tongue (HP:0000221)2.67586918
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.65684209
46Generalized tonic-clonic seizures (HP:0002069)2.63418809
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.61898829
48Abnormal social behavior (HP:0012433)2.61802025
49Impaired social interactions (HP:0000735)2.61802025
50Generalized hypopigmentation of hair (HP:0011358)2.59749630
51Aqueductal stenosis (HP:0002410)2.57931224
52Lissencephaly (HP:0001339)2.57479112
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.57296176
54Sclerocornea (HP:0000647)2.52915490
55Retinal atrophy (HP:0001105)2.50028098
56Absence seizures (HP:0002121)2.49895597
57Aplasia involving bones of the extremities (HP:0009825)2.49615152
58Aplasia involving bones of the upper limbs (HP:0009823)2.49615152
59Aplasia of the phalanges of the hand (HP:0009802)2.49615152
60Cerebellar dysplasia (HP:0007033)2.49604876
61Gait imbalance (HP:0002141)2.48543304
62Abnormality of liposaccharide metabolism (HP:0010968)2.47100576
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.47100576
64Abnormality of glycolipid metabolism (HP:0010969)2.47100576
65Increased corneal curvature (HP:0100692)2.44306052
66Keratoconus (HP:0000563)2.44306052
67Abolished electroretinogram (ERG) (HP:0000550)2.43716092
68Hypoplastic ischia (HP:0003175)2.42415852
69Diplopia (HP:0000651)2.42079066
70Abnormality of binocular vision (HP:0011514)2.42079066
71Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.41838018
72Vascular tortuosity (HP:0004948)2.39573190
73Concave nail (HP:0001598)2.37728208
74Exotropia (HP:0000577)2.35641275
75Abnormality of salivation (HP:0100755)2.35122791
76Abnormal respiratory epithelium morphology (HP:0012253)2.33712525
77Abnormal respiratory motile cilium morphology (HP:0005938)2.33712525
78Dialeptic seizures (HP:0011146)2.32010549
79Genetic anticipation (HP:0003743)2.31729202
80Aplasia/Hypoplasia of the tongue (HP:0010295)2.31408715
81Obstructive sleep apnea (HP:0002870)2.29868586
82Congenital primary aphakia (HP:0007707)2.29590643
83Hemiparesis (HP:0001269)2.29314764
84Abnormality of secondary sexual hair (HP:0009888)2.28418426
85Abnormality of the axillary hair (HP:0100134)2.28418426
86Congenital sensorineural hearing impairment (HP:0008527)2.27808658
87Urinary bladder sphincter dysfunction (HP:0002839)2.26675657
88Male pseudohermaphroditism (HP:0000037)2.26198413
89Absent speech (HP:0001344)2.25929983
90Pendular nystagmus (HP:0012043)2.23669467
91Anencephaly (HP:0002323)2.22152353
92Decreased circulating renin level (HP:0003351)2.21928969
93Hypoplastic labia majora (HP:0000059)2.20845158
94Abnormality of the ischium (HP:0003174)2.20650196
95Abnormal eating behavior (HP:0100738)2.20041843
96Abnormal respiratory motile cilium physiology (HP:0012261)2.19935167
97Widely spaced teeth (HP:0000687)2.18166992
98Congenital hepatic fibrosis (HP:0002612)2.17662292
99Dynein arm defect of respiratory motile cilia (HP:0012255)2.17080449
100Absent/shortened dynein arms (HP:0200106)2.17080449
101Gaze-evoked nystagmus (HP:0000640)2.16437666
102Renal cortical cysts (HP:0000803)2.15381124
103Retinal dysplasia (HP:0007973)2.14420179
104Polydipsia (HP:0001959)2.13705737
105Abnormal drinking behavior (HP:0030082)2.13705737
106Blue irides (HP:0000635)2.11967789
107Thyroid-stimulating hormone excess (HP:0002925)2.10731073
108Abnormal ciliary motility (HP:0012262)2.09470942
109Gastroesophageal reflux (HP:0002020)2.07628265
110Bronchomalacia (HP:0002780)2.06943438
111Nephrogenic diabetes insipidus (HP:0009806)2.05572053
112Hemiplegia (HP:0002301)2.03383589
113Abnormality of the labia majora (HP:0012881)2.02941827
114Clumsiness (HP:0002312)2.02658098
115Urethral obstruction (HP:0000796)2.02096747
116Inappropriate behavior (HP:0000719)2.01416877
117Megalencephaly (HP:0001355)2.01026081
118Chorioretinal atrophy (HP:0000533)2.00937004
119Genital tract atresia (HP:0001827)2.00846655
120Increased neuronal autofluorescent lipopigment (HP:0002074)1.99810900
121Global brain atrophy (HP:0002283)1.99035309
122Decreased central vision (HP:0007663)1.96420391
123Abnormality of the nasal septum (HP:0000419)1.96023439
124Limb dystonia (HP:0002451)1.95179718
125Dysdiadochokinesis (HP:0002075)1.94472636
126Vaginal atresia (HP:0000148)1.94414186
127Impaired smooth pursuit (HP:0007772)1.94006094
128Optic nerve hypoplasia (HP:0000609)1.93178353
129Neurofibrillary tangles (HP:0002185)1.90320661
130Depression (HP:0000716)1.90219022
131Truncal ataxia (HP:0002078)1.88985681
132Protruding tongue (HP:0010808)1.88738337
133Preaxial foot polydactyly (HP:0001841)1.88604616
134Spastic tetraparesis (HP:0001285)1.87688805
135Abnormality of the pubic bones (HP:0003172)1.86611923
136Postaxial foot polydactyly (HP:0001830)1.86005767
137Bradycardia (HP:0001662)1.85109006
138Fair hair (HP:0002286)1.83525886
139Poor coordination (HP:0002370)1.82313978
140Oligodactyly (hands) (HP:0001180)1.81602663
141Bony spicule pigmentary retinopathy (HP:0007737)1.81246698
142Polyphagia (HP:0002591)1.78702469
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78403384
144Abnormality of the pons (HP:0007361)1.78392556
145Mesangial abnormality (HP:0001966)1.78001686
146Stereotypic behavior (HP:0000733)1.77815502
147Bile duct proliferation (HP:0001408)1.76944689
148Abnormal biliary tract physiology (HP:0012439)1.76944689
149Insidious onset (HP:0003587)1.75546573
150Termporal pattern (HP:0011008)1.75546573
151Neuronal loss in central nervous system (HP:0002529)1.74854746
152Dysmetria (HP:0001310)1.74395040
153Prolonged QT interval (HP:0001657)1.74337243
154Systemic lupus erythematosus (HP:0002725)1.74187130
155Cerebral aneurysm (HP:0004944)1.73467550
156Abnormal EKG (HP:0003115)1.72287644
157Abnormality of ocular smooth pursuit (HP:0000617)1.71337675
158Impaired vibration sensation in the lower limbs (HP:0002166)1.71237510
159Ulnar claw (HP:0001178)1.70876275
160Intention tremor (HP:0002080)1.70156960
161Hip dysplasia (HP:0001385)1.65355455
162Status epilepticus (HP:0002133)1.64647747
163Elfin facies (HP:0004428)1.63777389
164Lower limb asymmetry (HP:0100559)1.63002662
165Narrow nasal bridge (HP:0000446)1.61512045
166Anxiety (HP:0000739)1.61381160
167Agitation (HP:0000713)1.60849028
168Palpebral edema (HP:0100540)1.60810719
169Dysostosis multiplex (HP:0000943)1.59398031
170Submucous cleft hard palate (HP:0000176)1.59348764
171Lower limb muscle weakness (HP:0007340)1.59252722
172Amblyopia (HP:0000646)1.58447247
173Nephronophthisis (HP:0000090)1.55561792
174Midline defect of the nose (HP:0004122)1.53723460
175Fetal akinesia sequence (HP:0001989)1.53269426
176* Deeply set eye (HP:0000490)1.53111178
177Limited hip movement (HP:0008800)1.52966860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.83663494
2NTRK34.11074802
3ACVR1B3.53180916
4EPHA43.30689264
5MAP3K42.99610106
6CASK2.97445633
7MARK12.61384888
8TNIK2.57032475
9NTRK22.49807939
10MAP2K72.46765215
11WNK32.33431012
12WNK42.22183682
13MAPK132.02586236
14GRK11.97815587
15TGFBR21.97368711
16CDK31.94893537
17CAMK1G1.92737859
18ZAK1.85853585
19MAP3K91.83378586
20TGFBR11.75056288
21RIPK41.73706368
22MAP2K41.67949233
23INSRR1.65306571
24MINK11.65143675
25SGK21.54287681
26MKNK21.49956830
27WEE11.48136800
28GRK71.47191058
29CAMK1D1.46801328
30LMTK21.45422228
31MAP3K61.43584403
32DAPK21.43063785
33TAOK31.42832983
34PHKG11.35340572
35PHKG21.35340572
36BMPR1B1.31238950
37OXSR11.29587123
38SGK2231.27132949
39SGK4941.27132949
40SIK21.27001709
41PRKD31.24019431
42FES1.23886986
43STK391.23526916
44CAMKK21.20221964
45MAP4K21.19660595
46PAK61.18822743
47SGK31.15498039
48CAMKK11.13163147
49ADRBK21.12830132
50PLK21.12591005
51PINK11.11559246
52STK381.07640745
53MAPK151.05107796
54CDK51.02288206
55TLK11.01449103
56BMPR20.97547268
57GRK50.96518973
58ERBB30.95981279
59PAK30.94543507
60FGR0.89372799
61NEK20.89088178
62MAPKAPK30.88703910
63IRAK20.87047621
64WNK10.85210938
65NTRK10.84511730
66PRKCG0.83254709
67CAMK2A0.82186844
68STK38L0.81825916
69FER0.81627285
70PNCK0.80994801
71KSR10.80032799
72SGK10.78457463
73LATS10.77573952
74MAP3K120.73501431
75PRKCE0.73102469
76MAPK120.73034067
77CAMK10.72650312
78PTK2B0.70993745
79CAMK40.70661992
80RET0.69184804
81NEK60.69103954
82STK110.68694080
83DYRK1A0.67858320
84MARK20.67020640
85MKNK10.66763595
86DYRK20.66531961
87MAPKAPK50.65731224
88PRKCH0.64640627
89LATS20.64149844
90TYRO30.62787863
91BRSK20.57945497
92RPS6KA50.57538376
93CHUK0.56938891
94IRAK30.56919857
95DMPK0.55942433
96CAMK2B0.54755765
97PKN10.54594041
98RPS6KA20.52652475
99OBSCN0.52159709
100PRKG10.51183765
101MAP2K10.50852459
102PRPF4B0.50481356
103MAPK70.50144138
104TRPM70.49654232
105ERBB20.49188663
106NUAK10.48993801
107RPS6KA60.48263329
108KSR20.48243043
109MAP3K130.46540249
110IGF1R0.46208523
111PRKACA0.45289277
112PIK3CA0.45076445
113TIE10.44538475
114MAP2K60.43942982
115TXK0.43738192
116RPS6KA30.43276904
117CSNK1G20.42061852
118NEK90.41334878
119FYN0.40579990
120EPHB20.39864472
121DAPK10.39728164
122MAPK100.38216593
123AKT30.37205886
124CHEK20.36535542
125PRKCQ0.36244909
126PIK3CG0.36189142
127MUSK0.35091154
128CDC42BPA0.34878020
129PRKAA10.34410510
130PDK20.34403761
131MAP3K70.33945087
132PDGFRA0.33878663
133ADRBK10.33789338
134PRKCA0.33686085
135STK30.33360021
136FGFR20.33090551
137IRAK10.32728733
138TSSK60.32131955
139PRKACB0.32047050
140PRKAA20.31904892
141PRKCZ0.31647780
142YES10.31439328
143KIT0.30130811
144NME10.29981159
145VRK10.28739798
146MELK0.28496201

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.14184641
2Linoleic acid metabolism_Homo sapiens_hsa005912.78832983
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.74592059
4Butanoate metabolism_Homo sapiens_hsa006502.74292027
5Nitrogen metabolism_Homo sapiens_hsa009102.63381273
6Olfactory transduction_Homo sapiens_hsa047402.56976003
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32794103
8Glutamatergic synapse_Homo sapiens_hsa047242.22947307
9Circadian entrainment_Homo sapiens_hsa047132.22327710
10Morphine addiction_Homo sapiens_hsa050322.15284326
11Synaptic vesicle cycle_Homo sapiens_hsa047212.08773816
12Long-term potentiation_Homo sapiens_hsa047202.06529649
13ABC transporters_Homo sapiens_hsa020102.06349286
14Tryptophan metabolism_Homo sapiens_hsa003802.04804991
15GABAergic synapse_Homo sapiens_hsa047271.98408421
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.94625026
17Salivary secretion_Homo sapiens_hsa049701.90243293
18Amphetamine addiction_Homo sapiens_hsa050311.86239316
19Taste transduction_Homo sapiens_hsa047421.75649657
20Renin secretion_Homo sapiens_hsa049241.74489549
21Insulin secretion_Homo sapiens_hsa049111.70323388
22Selenocompound metabolism_Homo sapiens_hsa004501.68929673
23Dopaminergic synapse_Homo sapiens_hsa047281.67152201
24Gastric acid secretion_Homo sapiens_hsa049711.66845128
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62820554
26Cholinergic synapse_Homo sapiens_hsa047251.60628936
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57900433
28Serotonergic synapse_Homo sapiens_hsa047261.56039099
29Calcium signaling pathway_Homo sapiens_hsa040201.53965957
30GnRH signaling pathway_Homo sapiens_hsa049121.49895589
31Axon guidance_Homo sapiens_hsa043601.47103618
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45509583
33Long-term depression_Homo sapiens_hsa047301.43756548
34Caffeine metabolism_Homo sapiens_hsa002321.42155800
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39914838
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39505846
37cAMP signaling pathway_Homo sapiens_hsa040241.39473187
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.38578817
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37600864
40Histidine metabolism_Homo sapiens_hsa003401.37169713
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35821600
42Oxytocin signaling pathway_Homo sapiens_hsa049211.34775179
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34580085
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.32442066
45Cocaine addiction_Homo sapiens_hsa050301.32413652
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.31611248
47Type II diabetes mellitus_Homo sapiens_hsa049301.31239588
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30971060
49Homologous recombination_Homo sapiens_hsa034401.29867327
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24186492
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23922222
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21443285
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10114576
54Chemical carcinogenesis_Homo sapiens_hsa052041.08630298
55Gap junction_Homo sapiens_hsa045401.08410888
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07719691
57Cardiac muscle contraction_Homo sapiens_hsa042601.06488408
58Glycerolipid metabolism_Homo sapiens_hsa005611.06102026
59Estrogen signaling pathway_Homo sapiens_hsa049151.05101569
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03553694
61Arachidonic acid metabolism_Homo sapiens_hsa005901.02597348
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01787529
63Glycosaminoglycan degradation_Homo sapiens_hsa005311.00631538
64Fanconi anemia pathway_Homo sapiens_hsa034601.00275201
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98003478
66Melanogenesis_Homo sapiens_hsa049160.96047411
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94322021
68Oxidative phosphorylation_Homo sapiens_hsa001900.94250771
69Collecting duct acid secretion_Homo sapiens_hsa049660.93170908
70Retinol metabolism_Homo sapiens_hsa008300.92881889
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91249088
72Dilated cardiomyopathy_Homo sapiens_hsa054140.90840058
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88866422
74Glioma_Homo sapiens_hsa052140.88655724
75Dorso-ventral axis formation_Homo sapiens_hsa043200.87450353
76Basal transcription factors_Homo sapiens_hsa030220.86978915
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.85607748
78Circadian rhythm_Homo sapiens_hsa047100.84856123
79Rap1 signaling pathway_Homo sapiens_hsa040150.84514552
80ErbB signaling pathway_Homo sapiens_hsa040120.84039426
81Inositol phosphate metabolism_Homo sapiens_hsa005620.81985934
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.81951588
83Ovarian steroidogenesis_Homo sapiens_hsa049130.81894047
84beta-Alanine metabolism_Homo sapiens_hsa004100.81561108
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79492894
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78983414
87Propanoate metabolism_Homo sapiens_hsa006400.78584493
88Choline metabolism in cancer_Homo sapiens_hsa052310.78389559
89MAPK signaling pathway_Homo sapiens_hsa040100.78043879
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77677083
91Fatty acid biosynthesis_Homo sapiens_hsa000610.77378235
92Ras signaling pathway_Homo sapiens_hsa040140.75154476
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74851693
94Pancreatic secretion_Homo sapiens_hsa049720.74201318
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68273192
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67597933
97Ether lipid metabolism_Homo sapiens_hsa005650.67483634
98Peroxisome_Homo sapiens_hsa041460.66666145
99Fat digestion and absorption_Homo sapiens_hsa049750.65829032
100Parkinsons disease_Homo sapiens_hsa050120.65134118
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64715969
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.63706661
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63302545
104Adherens junction_Homo sapiens_hsa045200.61071299
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.60993128
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.60721674
107Prion diseases_Homo sapiens_hsa050200.59641283
108Bile secretion_Homo sapiens_hsa049760.59442915
109Basal cell carcinoma_Homo sapiens_hsa052170.59279708
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58476812
111Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58168261
112Wnt signaling pathway_Homo sapiens_hsa043100.57851619
113Lysosome_Homo sapiens_hsa041420.56655910
114Thyroid hormone synthesis_Homo sapiens_hsa049180.56566413
115Colorectal cancer_Homo sapiens_hsa052100.55767076
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55217785
117Osteoclast differentiation_Homo sapiens_hsa043800.55034866
118Glucagon signaling pathway_Homo sapiens_hsa049220.54322366
119Huntingtons disease_Homo sapiens_hsa050160.53963565
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53107332
121Vibrio cholerae infection_Homo sapiens_hsa051100.52294794
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.51794484
123Hedgehog signaling pathway_Homo sapiens_hsa043400.51670218
124Endocytosis_Homo sapiens_hsa041440.50618463
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50496179
126Phototransduction_Homo sapiens_hsa047440.50148229
127Alzheimers disease_Homo sapiens_hsa050100.49230189
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48343784
129Sulfur relay system_Homo sapiens_hsa041220.47588967
130Melanoma_Homo sapiens_hsa052180.47175909
131Endometrial cancer_Homo sapiens_hsa052130.47158583
132RNA polymerase_Homo sapiens_hsa030200.45891926
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45568876
134African trypanosomiasis_Homo sapiens_hsa051430.45287497
135Mineral absorption_Homo sapiens_hsa049780.45253618
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.44183687
137Platelet activation_Homo sapiens_hsa046110.43559091
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42704114
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42407249
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42342315
141Chemokine signaling pathway_Homo sapiens_hsa040620.42336881
142VEGF signaling pathway_Homo sapiens_hsa043700.41938034
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40879029
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40476558
145FoxO signaling pathway_Homo sapiens_hsa040680.39954763
146Renal cell carcinoma_Homo sapiens_hsa052110.39881511
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39397047
148Asthma_Homo sapiens_hsa053100.38781281
149Vitamin digestion and absorption_Homo sapiens_hsa049770.35913650
150Regulation of autophagy_Homo sapiens_hsa041400.35775074
151Lysine degradation_Homo sapiens_hsa003100.34836572
152Protein export_Homo sapiens_hsa030600.34047328
153Hippo signaling pathway_Homo sapiens_hsa043900.33978425
154Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31187048

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »