OPLAH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.66957121
2L-phenylalanine catabolic process (GO:0006559)6.66957121
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.60831478
4L-phenylalanine metabolic process (GO:0006558)6.60831478
5aromatic amino acid family catabolic process (GO:0009074)6.00781971
6glyoxylate metabolic process (GO:0046487)5.73221409
7sulfur amino acid catabolic process (GO:0000098)5.63311953
8alpha-linolenic acid metabolic process (GO:0036109)5.44535524
9tryptophan catabolic process (GO:0006569)5.44410298
10indole-containing compound catabolic process (GO:0042436)5.44410298
11indolalkylamine catabolic process (GO:0046218)5.44410298
12kynurenine metabolic process (GO:0070189)5.43859789
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.38136639
14lysine metabolic process (GO:0006553)5.27338630
15lysine catabolic process (GO:0006554)5.27338630
16cysteine metabolic process (GO:0006534)5.26365257
17bile acid biosynthetic process (GO:0006699)5.20890786
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.08474732
19tryptophan metabolic process (GO:0006568)5.07998285
20serine family amino acid catabolic process (GO:0009071)4.88823339
21urea cycle (GO:0000050)4.84225741
22urea metabolic process (GO:0019627)4.84225741
23amino-acid betaine metabolic process (GO:0006577)4.76631000
24bile acid metabolic process (GO:0008206)4.57346982
25regulation of triglyceride catabolic process (GO:0010896)4.54654129
26homocysteine metabolic process (GO:0050667)4.54412312
27nitrogen cycle metabolic process (GO:0071941)4.53562080
28acetyl-CoA metabolic process (GO:0006084)4.53296165
29complement activation, alternative pathway (GO:0006957)4.51692617
30high-density lipoprotein particle remodeling (GO:0034375)4.44968705
31protein carboxylation (GO:0018214)4.43387097
32peptidyl-glutamic acid carboxylation (GO:0017187)4.43387097
33fatty acid beta-oxidation (GO:0006635)4.42796765
34cellular ketone body metabolic process (GO:0046950)4.42569906
35negative regulation of fibrinolysis (GO:0051918)4.42375176
36triglyceride homeostasis (GO:0070328)4.41989866
37acylglycerol homeostasis (GO:0055090)4.41989866
38regulation of protein activation cascade (GO:2000257)4.41553726
39alpha-amino acid catabolic process (GO:1901606)4.39846414
40aromatic amino acid family metabolic process (GO:0009072)4.38185725
41regulation of fibrinolysis (GO:0051917)4.25029902
42cellular amino acid catabolic process (GO:0009063)4.19406288
43fatty acid oxidation (GO:0019395)4.17422221
44short-chain fatty acid metabolic process (GO:0046459)4.15139222
45regulation of complement activation (GO:0030449)4.13436013
46lipid oxidation (GO:0034440)4.10357403
47fatty acid catabolic process (GO:0009062)4.07164435
48tyrosine metabolic process (GO:0006570)4.05759864
49aspartate family amino acid catabolic process (GO:0009068)4.04163157
50fatty acid transmembrane transport (GO:1902001)4.03094407
51glutamate metabolic process (GO:0006536)4.00168927
522-oxoglutarate metabolic process (GO:0006103)3.99767969
53coenzyme catabolic process (GO:0009109)3.97637157
54regulation of cholesterol homeostasis (GO:2000188)3.97253716
55ethanol oxidation (GO:0006069)3.96936037
56monocarboxylic acid catabolic process (GO:0072329)3.93843053
57reverse cholesterol transport (GO:0043691)3.93383053
58cellular modified amino acid catabolic process (GO:0042219)3.92842152
59positive regulation of fatty acid beta-oxidation (GO:0032000)3.91950552
60carboxylic acid catabolic process (GO:0046395)3.89043882
61organic acid catabolic process (GO:0016054)3.89043882
62carnitine metabolic process (GO:0009437)3.88793309
63serine family amino acid metabolic process (GO:0009069)3.88597142
64negative regulation of fatty acid biosynthetic process (GO:0045717)3.88544620
65protein-lipid complex remodeling (GO:0034368)3.85958882
66macromolecular complex remodeling (GO:0034367)3.85958882
67plasma lipoprotein particle remodeling (GO:0034369)3.85958882
68regulation of cholesterol esterification (GO:0010872)3.85267427
69plasma lipoprotein particle clearance (GO:0034381)3.83379130
70negative regulation of cholesterol transport (GO:0032375)3.82826440
71negative regulation of sterol transport (GO:0032372)3.82826440
72ketone body metabolic process (GO:1902224)3.80862269
73drug catabolic process (GO:0042737)3.79203651
74carnitine shuttle (GO:0006853)3.78622109
75drug transmembrane transport (GO:0006855)3.77287620
76desmosome organization (GO:0002934)3.76582968
77benzene-containing compound metabolic process (GO:0042537)3.76018900
78indolalkylamine metabolic process (GO:0006586)3.73870094
79dicarboxylic acid biosynthetic process (GO:0043650)3.72675884
80mannose metabolic process (GO:0006013)3.72539799
81cellular glucuronidation (GO:0052695)3.71380598
82glycine metabolic process (GO:0006544)3.71007626
83cellular biogenic amine catabolic process (GO:0042402)3.67203059
84amine catabolic process (GO:0009310)3.67203059
85biotin metabolic process (GO:0006768)3.65106120
86positive regulation of lipid catabolic process (GO:0050996)3.64999834
87regulation of apoptotic cell clearance (GO:2000425)3.64727046
88proline metabolic process (GO:0006560)3.64539327
89phospholipid efflux (GO:0033700)3.63128241
90valine metabolic process (GO:0006573)3.60918591
91urate metabolic process (GO:0046415)3.59752265
92very-low-density lipoprotein particle assembly (GO:0034379)3.59564766
93cholesterol efflux (GO:0033344)3.59448562
94cytolysis (GO:0019835)3.59247535
95bile acid and bile salt transport (GO:0015721)3.58120359
96heme transport (GO:0015886)3.50988572
97regulation of bile acid biosynthetic process (GO:0070857)3.50165147
98phospholipid homeostasis (GO:0055091)3.47678266
99apoptotic process involved in morphogenesis (GO:0060561)3.47398719
100plasma lipoprotein particle assembly (GO:0034377)3.47268885
101branched-chain amino acid catabolic process (GO:0009083)3.44227578
102exogenous drug catabolic process (GO:0042738)3.43620842
103cholesterol homeostasis (GO:0042632)3.43460732
104glutamine family amino acid biosynthetic process (GO:0009084)3.43279034
105cell-cell junction maintenance (GO:0045217)3.31494720
106response to mercury ion (GO:0046689)3.25643028
107positive regulation of triglyceride lipase activity (GO:0061365)3.25201168
108positive regulation of lipoprotein lipase activity (GO:0051006)3.25201168
109creatine metabolic process (GO:0006600)3.25020309
110negative regulation of erythrocyte differentiation (GO:0045647)3.21569867
111actin-myosin filament sliding (GO:0033275)3.19030328
112muscle filament sliding (GO:0030049)3.19030328
113NADH metabolic process (GO:0006734)3.18098372
114epithelial cell-cell adhesion (GO:0090136)3.04896296
115focal adhesion assembly (GO:0048041)3.00819781
116cell-substrate adherens junction assembly (GO:0007045)3.00819781
117endothelial cell chemotaxis (GO:0035767)2.96924991
118semaphorin-plexin signaling pathway (GO:0071526)2.95767916
119regulation of ARF GTPase activity (GO:0032312)2.95523466
120low-density lipoprotein particle clearance (GO:0034383)2.94865580
121myofibril assembly (GO:0030239)2.92567526
122negative regulation of cell size (GO:0045792)2.88087797
123adherens junction assembly (GO:0034333)2.84959754
124sarcomere organization (GO:0045214)2.84400849
125oxaloacetate metabolic process (GO:0006107)2.84038414
126bundle of His cell to Purkinje myocyte communication (GO:0086069)2.83320093
127basement membrane organization (GO:0071711)2.83304280
128regulation of fatty acid biosynthetic process (GO:0042304)2.82449412
129barbed-end actin filament capping (GO:0051016)2.80020581
130positive regulation of receptor recycling (GO:0001921)2.78696811
131cell junction maintenance (GO:0034331)2.78035377
132positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.77625447
133cell volume homeostasis (GO:0006884)2.77393476
134regulation of cholesterol biosynthetic process (GO:0045540)2.76941762
135fructose metabolic process (GO:0006000)2.75390506
136cell-substrate junction assembly (GO:0007044)2.72788166
137protein retention in ER lumen (GO:0006621)2.72730882
138diacylglycerol metabolic process (GO:0046339)2.70502665
139negative regulation of fatty acid transport (GO:2000192)2.68764547
140carnitine transmembrane transport (GO:1902603)2.66803794
141glucose 6-phosphate metabolic process (GO:0051156)2.65557133
142response to muscle activity (GO:0014850)2.65440094
143cardiac myofibril assembly (GO:0055003)2.63237437
144positive regulation of triglyceride metabolic process (GO:0090208)2.62074008
145positive regulation of Cdc42 GTPase activity (GO:0043089)2.61934343
146cardiac muscle contraction (GO:0060048)2.59695843
147skeletal muscle contraction (GO:0003009)2.57888292
148protein-lipid complex assembly (GO:0065005)2.57701947
149activation of Rac GTPase activity (GO:0032863)2.56370852
150atrioventricular valve morphogenesis (GO:0003181)2.55963871
151actin-mediated cell contraction (GO:0070252)2.55341388
152glycogen catabolic process (GO:0005980)2.54052712
153amino-acid betaine transport (GO:0015838)2.53827130
154carnitine transport (GO:0015879)2.53827130
155regulation of cholesterol metabolic process (GO:0090181)2.53142070
156positive regulation of fatty acid biosynthetic process (GO:0045723)2.51893245
157response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.51716473
158insulin-like growth factor receptor signaling pathway (GO:0048009)2.50956046
159acute-phase response (GO:0006953)2.50521427
160hemidesmosome assembly (GO:0031581)2.49780618
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49483199
162epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49347192
163glucan catabolic process (GO:0009251)2.48247792
164proline biosynthetic process (GO:0006561)2.46145962
165embryonic process involved in female pregnancy (GO:0060136)2.45921073
166cytoskeletal anchoring at plasma membrane (GO:0007016)2.45249346
167regulation of plasminogen activation (GO:0010755)2.44628903
168quaternary ammonium group transport (GO:0015697)2.44400136
169planar cell polarity pathway involved in neural tube closure (GO:0090179)2.43582337
170striated muscle contraction (GO:0006941)2.40888280
171regulation of hydrogen peroxide metabolic process (GO:0010310)2.40205592

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.87533219
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.39069714
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.33943068
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.10224898
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.75091861
6EGR1_23403033_ChIP-Seq_LIVER_Mouse5.06711283
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.87416673
8* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.84285230
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.81479465
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.04172680
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.76966617
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62191193
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.26401753
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.25396887
15VDR_21846776_ChIP-Seq_THP-1_Human2.23874545
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16616875
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13274045
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.12673588
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99651485
20KDM2B_26808549_Chip-Seq_DND41_Human1.98764264
21KDM2B_26808549_Chip-Seq_K562_Human1.90602994
22* TCF7_22412390_ChIP-Seq_EML_Mouse1.87432687
23CLOCK_20551151_ChIP-Seq_293T_Human1.84517564
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77384615
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71662859
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.64806328
27* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.60127647
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59982875
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.56118936
30UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54231280
31CTCF_27219007_Chip-Seq_ERYTHROID_Human1.50661845
32MYC_22102868_ChIP-Seq_BL_Human1.49432304
33ZNF263_19887448_ChIP-Seq_K562_Human1.49258993
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45033543
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44792714
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.44222750
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41895732
38KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40393902
39* LXR_22292898_ChIP-Seq_THP-1_Human1.38857763
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37443562
41RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37387452
42RXRA_24833708_ChIP-Seq_LIVER_Mouse1.36641271
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33750215
44* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31897423
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.29179571
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.27809223
47ATF3_27146783_Chip-Seq_COLON_Human1.26388452
48NCOR1_26117541_ChIP-Seq_K562_Human1.25662527
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24831731
50HNF4A_19822575_ChIP-Seq_HepG2_Human1.24470370
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23421380
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.22485856
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.20174763
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19297988
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.17160846
56MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16698342
57VDR_24763502_ChIP-Seq_THP-1_Human1.15114403
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14560770
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13856336
60GATA1_19941826_ChIP-Seq_K562_Human1.12840332
61* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12441729
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11672016
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10970080
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09210680
65TP53_22127205_ChIP-Seq_IMR90_Human1.09018447
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07174361
67PHF8_20622854_ChIP-Seq_HELA_Human1.05182143
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04018664
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04018229
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.03605090
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02070507
72MAF_26560356_Chip-Seq_TH2_Human0.99789971
73DROSHA_22980978_ChIP-Seq_HELA_Human0.98165508
74JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97817528
75UBF1/2_26484160_Chip-Seq_HMECs_Human0.97075466
76NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96596999
77* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96505001
78CTCF_21964334_Chip-Seq_Bcells_Human0.96161146
79SPI1_23127762_ChIP-Seq_K562_Human0.95996875
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94468706
81ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93919497
82* RACK7_27058665_Chip-Seq_MCF-7_Human0.93067150
83HTT_18923047_ChIP-ChIP_STHdh_Human0.92846738
84* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92418037
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91855920
86RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90815965
87RARA_24833708_ChIP-Seq_LIVER_Mouse0.89421173
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86178138
89RARB_24833708_ChIP-Seq_LIVER_Mouse0.84999884
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84372183
91TET1_21451524_ChIP-Seq_MESCs_Mouse0.83841069
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82876922
93* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81956163
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81829488
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80266944
96TP63_17297297_ChIP-ChIP_HaCaT_Human0.79905189
97CTCF_27219007_Chip-Seq_Bcells_Human0.79707890
98ESR1_21235772_ChIP-Seq_MCF-7_Human0.79133115
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78374636
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.77732143
101TBX20_22328084_ChIP-Seq_HEART_Mouse0.76476798
102TBX20_22080862_ChIP-Seq_HEART_Mouse0.76476798
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76039240
104CDX2_20551321_ChIP-Seq_CACO-2_Human0.74797604
105TRIM28_21343339_ChIP-Seq_HEK293_Human0.74325219
106ESR1_20079471_ChIP-ChIP_T-47D_Human0.72435885
107GATA4_25053715_ChIP-Seq_YYC3_Human0.72189225
108POU5F1_16518401_ChIP-PET_MESCs_Mouse0.71827360
109* BCOR_27268052_Chip-Seq_Bcells_Human0.70417899
110* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69312656
111PPAR_26484153_Chip-Seq_NCI-H1993_Human0.68964880
112* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.67482999
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67465636
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67420447
115* MYC_27129775_Chip-Seq_CORNEA_Mouse0.66885809
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.65026616
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64483351
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.64246213
119CTCF_21964334_ChIP-Seq_BJAB-B_Human0.63115445
120EGR1_19032775_ChIP-ChIP_M12_Human0.63033715
121NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.62709192
122CREB1_26743006_Chip-Seq_LNCaP_Human0.61882603
123STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.60452950
124CSB_26484114_Chip-Seq_FIBROBLAST_Human0.60068790
125E2F1_20622854_ChIP-Seq_HELA_Human0.60021834
126P63_26484246_Chip-Seq_KERATINOCYTES_Human0.59066454
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.59044423
128* P68_20966046_ChIP-Seq_HELA_Human0.58802036
129TP63_22573176_ChIP-Seq_HFKS_Human0.58733083
130* BCL6_27268052_Chip-Seq_Bcells_Human0.57485646
131FOXO3_23340844_ChIP-Seq_DLD1_Human0.57049559
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.56755918
133SPI1_26923725_Chip-Seq_HPCs_Mouse0.56318470
134CEBPB_22108803_ChIP-Seq_LS180_Human0.55928399
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.55556118
136SALL4_18804426_ChIP-ChIP_XEN_Mouse0.55504466
137ESET_19884257_ChIP-Seq_ESCs_Mouse0.55350673
138SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.54931019
139NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.54801977
140GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.54403129
141* SMC4_20622854_ChIP-Seq_HELA_Human0.54301945
142RAC3_21632823_ChIP-Seq_H3396_Human0.52918208
143SA1_27219007_Chip-Seq_Bcells_Human0.52345547
144DNAJC2_21179169_ChIP-ChIP_NT2_Human0.51301981
145SA1_27219007_Chip-Seq_ERYTHROID_Human0.50977114
146SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.50963616
147GATA6_25053715_ChIP-Seq_YYC3_Human0.50218866
148TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.50009638
149P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.49025594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.46942816
2MP0005360_urolithiasis7.06969858
3MP0005085_abnormal_gallbladder_physiolo5.96894365
4MP0005365_abnormal_bile_salt5.89993508
5MP0008875_abnormal_xenobiotic_pharmacok4.66245500
6MP0003806_abnormal_nucleotide_metabolis3.69125025
7MP0003252_abnormal_bile_duct3.51090303
8MP0010329_abnormal_lipoprotein_level3.36416700
9MP0005332_abnormal_amino_acid3.13232944
10MP0003195_calcinosis2.83194198
11MP0009840_abnormal_foam_cell2.73533304
12MP0005083_abnormal_biliary_tract2.56629222
13MP0004019_abnormal_vitamin_homeostasis2.54078343
14MP0004084_abnormal_cardiac_muscle2.43580521
15MP0001666_abnormal_nutrient_absorption2.33735653
16MP0003191_abnormal_cellular_cholesterol2.30273139
17MP0002118_abnormal_lipid_homeostasis2.23023005
18MP0010234_abnormal_vibrissa_follicle2.20603181
19MP0005670_abnormal_white_adipose2.19595892
20MP0000749_muscle_degeneration2.17925021
21MP0000678_abnormal_parathyroid_gland2.15473049
22MP0001849_ear_inflammation2.10404506
23MP0000609_abnormal_liver_physiology2.05943660
24MP0000747_muscle_weakness1.90770036
25MP0005319_abnormal_enzyme/_coenzyme1.84285722
26MP0002138_abnormal_hepatobiliary_system1.82536679
27MP0004510_myositis1.82060361
28MP0005076_abnormal_cell_differentiation1.76255792
29MP0000013_abnormal_adipose_tissue1.75538655
30MP0003566_abnormal_cell_adhesion1.72721584
31MP0005409_darkened_coat_color1.66197156
32MP0004130_abnormal_muscle_cell1.63940755
33MP0005584_abnormal_enzyme/coenzyme_acti1.61862199
34MP0006138_congestive_heart_failure1.58370658
35MP0000566_synostosis1.54790502
36MP0000003_abnormal_adipose_tissue1.54207539
37MP0003172_abnormal_lysosome_physiology1.54201692
38MP0004858_abnormal_nervous_system1.52061596
39MP0001764_abnormal_homeostasis1.49961187
40MP0009643_abnormal_urine_homeostasis1.49913896
41MP0005666_abnormal_adipose_tissue1.44435697
42MP0005410_abnormal_fertilization1.43665382
43MP0003705_abnormal_hypodermis_morpholog1.41610466
44MP0000759_abnormal_skeletal_muscle1.38651954
45MP0005451_abnormal_body_composition1.38211839
46MP0002837_dystrophic_cardiac_calcinosis1.35597431
47MP0002971_abnormal_brown_adipose1.31561291
48MP0004272_abnormal_basement_membrane1.28757409
49MP0003879_abnormal_hair_cell1.28499828
50MP0004145_abnormal_muscle_electrophysio1.28463370
51MP0003868_abnormal_feces_composition1.27654429
52MP0008004_abnormal_stomach_pH1.26149623
53MP0006036_abnormal_mitochondrial_physio1.25409657
54MP0003186_abnormal_redox_activity1.24772095
55MP0002108_abnormal_muscle_morphology1.21365773
56MP0003878_abnormal_ear_physiology1.20788142
57MP0005377_hearing/vestibular/ear_phenot1.20788142
58MP0002254_reproductive_system_inflammat1.18453453
59MP0008260_abnormal_autophagy1.17019527
60MP0002972_abnormal_cardiac_muscle1.16591863
61MP0005647_abnormal_sex_gland1.15240992
62MP0005620_abnormal_muscle_contractility1.09960523
63MP0002106_abnormal_muscle_physiology1.09484090
64MP0005369_muscle_phenotype1.04868681
65MP0003656_abnormal_erythrocyte_physiolo1.02731639
66MP0000598_abnormal_liver_morphology1.01683226
67MP0002132_abnormal_respiratory_system1.01516542
68MP0003436_decreased_susceptibility_to1.00894553
69MP0002796_impaired_skin_barrier1.00779352
70MP0000467_abnormal_esophagus_morphology0.99437692
71MP0000750_abnormal_muscle_regeneration0.99275093
72MP0003011_delayed_dark_adaptation0.98370643
73MP0000579_abnormal_nail_morphology0.96165208
74MP0005636_abnormal_mineral_homeostasis0.94752519
75MP0004381_abnormal_hair_follicle0.94717271
76MP0005535_abnormal_body_temperature0.93813210
77MP0004264_abnormal_extraembryonic_tissu0.93639270
78MP0003091_abnormal_cell_migration0.92792865
79MP0004043_abnormal_pH_regulation0.91088497
80MP0003045_fibrosis0.89863382
81MP0005330_cardiomyopathy0.89448088
82MP0009278_abnormal_bone_marrow0.88434286
83MP0000537_abnormal_urethra_morphology0.88321146
84MP0000733_abnormal_muscle_development0.88079714
85MP0004947_skin_inflammation0.87420161
86MP0005023_abnormal_wound_healing0.87083753
87MP0005334_abnormal_fat_pad0.86925827
88MP0002078_abnormal_glucose_homeostasis0.86923830
89MP0004185_abnormal_adipocyte_glucose0.85934801
90MP0001661_extended_life_span0.85194893
91MP0000604_amyloidosis0.84394599
92MP0001756_abnormal_urination0.84122544
93MP0005266_abnormal_metabolism0.84046615
94MP0002998_abnormal_bone_remodeling0.83410308
95MP0002933_joint_inflammation0.81735613
96MP0001544_abnormal_cardiovascular_syste0.81527314
97MP0005385_cardiovascular_system_phenoty0.81527314
98MP0002269_muscular_atrophy0.80868580
99MP0003828_pulmonary_edema0.80501722
100MP0005376_homeostasis/metabolism_phenot0.79303242
101MP0009642_abnormal_blood_homeostasis0.79000011
102MP0002089_abnormal_postnatal_growth/wei0.77943395
103MP0009115_abnormal_fat_cell0.77147801
104MP0003646_muscle_fatigue0.76689462
105MP0005375_adipose_tissue_phenotype0.76562753
106MP0009764_decreased_sensitivity_to0.75779381
107MP0008438_abnormal_cutaneous_collagen0.75227570
108MP0005503_abnormal_tendon_morphology0.74482396
109MP0003690_abnormal_glial_cell0.73646563
110MP0001873_stomach_inflammation0.72353463
111MP0009763_increased_sensitivity_to0.71587278
112MP0003329_amyloid_beta_deposits0.70065470
113MP0003315_abnormal_perineum_morphology0.69445528
114MP0001348_abnormal_lacrimal_gland0.68598347
115MP0000767_abnormal_smooth_muscle0.68585770
116MP0000858_altered_metastatic_potential0.68083246
117MP0009697_abnormal_copulation0.66921466
118MP0002136_abnormal_kidney_physiology0.64992933
119MP0003279_aneurysm0.64803887
120MP0002876_abnormal_thyroid_physiology0.63594901
121MP0004233_abnormal_muscle_weight0.63093572
122MP0002970_abnormal_white_adipose0.62389123
123MP0006035_abnormal_mitochondrial_morpho0.62049833
124MP0010368_abnormal_lymphatic_system0.61987469
125MP0005448_abnormal_energy_balance0.60079857
126MP0000639_abnormal_adrenal_gland0.59495476
127MP0008469_abnormal_protein_level0.58629166
128MP0002332_abnormal_exercise_endurance0.57505337
129MP0002168_other_aberrant_phenotype0.57356272
130MP0003453_abnormal_keratinocyte_physiol0.56013545
131MP0003638_abnormal_response/metabolism_0.55696865
132MP0005058_abnormal_lysosome_morphology0.55445712
133MP0002060_abnormal_skin_morphology0.53357228
134MP0005395_other_phenotype0.52641783
135MP0003953_abnormal_hormone_level0.50768876
136MP0000751_myopathy0.50433091
137MP0009053_abnormal_anal_canal0.50355365
138MP0008874_decreased_physiological_sensi0.49676861
139MP0003075_altered_response_to0.49295292
140MP0005220_abnormal_exocrine_pancreas0.49114521
141MP0001765_abnormal_ion_homeostasis0.46475671
142MP0000230_abnormal_systemic_arterial0.44199026
143MP0004087_abnormal_muscle_fiber0.43063574
144MP0005084_abnormal_gallbladder_morpholo0.40972512
145MP0009765_abnormal_xenobiotic_induced0.40810302
146MP0008872_abnormal_physiological_respon0.39793286
147MP0004782_abnormal_surfactant_physiolog0.39279685
148MP0010630_abnormal_cardiac_muscle0.38056720
149MP0008961_abnormal_basal_metabolism0.37994625
150MP0008775_abnormal_heart_ventricle0.36806725
151MP0002928_abnormal_bile_duct0.36737170
152MP0005248_abnormal_Harderian_gland0.36705425
153MP0003959_abnormal_lean_body0.36256155
154MP0010030_abnormal_orbit_morphology0.35946871
155MP0002249_abnormal_larynx_morphology0.35509079
156MP0004036_abnormal_muscle_relaxation0.34699457
157MP0005501_abnormal_skin_physiology0.33163235

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.33940986
2Intrahepatic cholestasis (HP:0001406)6.11946746
3Deep venous thrombosis (HP:0002625)5.93437935
4Xanthomatosis (HP:0000991)5.65237569
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.49196886
6Hypobetalipoproteinemia (HP:0003563)5.17463822
7Hyperglycinuria (HP:0003108)5.00035458
8Hyperammonemia (HP:0001987)4.89211156
9Prolonged partial thromboplastin time (HP:0003645)4.86469017
10Hyperlipoproteinemia (HP:0010980)4.81741165
11Ketosis (HP:0001946)4.79253836
12Abnormality of glycine metabolism (HP:0010895)4.58946373
13Abnormality of serine family amino acid metabolism (HP:0010894)4.58946373
14Complement deficiency (HP:0004431)4.51643850
15Hyperglycinemia (HP:0002154)4.45058086
16Abnormality of glutamine family amino acid metabolism (HP:0010902)4.34588916
17Hypolipoproteinemia (HP:0010981)4.24241833
18Ketoacidosis (HP:0001993)4.09516777
19Hypoglycemic coma (HP:0001325)4.07501936
20Increased connective tissue (HP:0009025)4.06782986
21Abnormality of fatty-acid metabolism (HP:0004359)4.05870888
22Hypoalphalipoproteinemia (HP:0003233)4.04689227
23Epidermoid cyst (HP:0200040)4.02222868
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.88591801
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.86292557
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.78911543
27Distal lower limb muscle weakness (HP:0009053)3.75992956
28Centrally nucleated skeletal muscle fibers (HP:0003687)3.65988606
29Joint hemorrhage (HP:0005261)3.55314132
30Type 1 muscle fiber predominance (HP:0003803)3.54072833
31Asymmetric septal hypertrophy (HP:0001670)3.47996052
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.46348007
33Abnormality of methionine metabolism (HP:0010901)3.45575753
34Gout (HP:0001997)3.41127160
35Fat malabsorption (HP:0002630)3.35822627
36Right ventricular cardiomyopathy (HP:0011663)3.32051871
37Hyporeflexia of lower limbs (HP:0002600)3.30699699
38Abnormality of the common coagulation pathway (HP:0010990)3.29908487
39Abnormality of complement system (HP:0005339)3.27956354
40Abnormality of dicarboxylic acid metabolism (HP:0010995)3.22093293
41Dicarboxylic aciduria (HP:0003215)3.22093293
42Muscle fiber splitting (HP:0003555)3.19211370
43Myopathic facies (HP:0002058)3.15034456
44Abnormality of purine metabolism (HP:0004352)3.09913244
45Distal lower limb amyotrophy (HP:0008944)3.08440934
46Delayed CNS myelination (HP:0002188)3.06883976
47Muscle fiber inclusion bodies (HP:0100299)3.06083173
48Hypercholesterolemia (HP:0003124)3.03414982
49Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.00726639
50Abnormality of nucleobase metabolism (HP:0010932)2.99360474
51Lethargy (HP:0001254)2.93231598
52Abnormality of serum amino acid levels (HP:0003112)2.93202971
53Metabolic acidosis (HP:0001942)2.92396634
54Myocardial infarction (HP:0001658)2.88672938
55Cerebral aneurysm (HP:0004944)2.88411354
56Myoglobinuria (HP:0002913)2.83743806
57Hypochromic microcytic anemia (HP:0004840)2.82021314
58Increased variability in muscle fiber diameter (HP:0003557)2.81899712
59Bulbar palsy (HP:0001283)2.81487384
60Obstructive sleep apnea (HP:0002870)2.80180782
61Stridor (HP:0010307)2.79505804
62Abnormality of pyrimidine metabolism (HP:0004353)2.78254934
63Nemaline bodies (HP:0003798)2.76339819
64Abnormality of skeletal muscle fiber size (HP:0012084)2.75239291
65Sudden death (HP:0001699)2.74040350
66Ventricular tachycardia (HP:0004756)2.70200125
67Hyperbilirubinemia (HP:0002904)2.69764773
68Difficulty climbing stairs (HP:0003551)2.68250238
69Abnormality of the intrinsic pathway (HP:0010989)2.67784578
70Glomerulonephritis (HP:0000099)2.65782038
71Flat acetabular roof (HP:0003180)2.62555441
72Generalized aminoaciduria (HP:0002909)2.62228119
73Cerebral edema (HP:0002181)2.61918746
74Conjugated hyperbilirubinemia (HP:0002908)2.57010489
75EMG: myopathic abnormalities (HP:0003458)2.54495975
76Mildly elevated creatine phosphokinase (HP:0008180)2.53520735
77Increased purine levels (HP:0004368)2.51225639
78Hyperuricemia (HP:0002149)2.51225639
79Steatorrhea (HP:0002570)2.50766242
80Skin nodule (HP:0200036)2.50478161
81Malnutrition (HP:0004395)2.49716517
82Vascular calcification (HP:0004934)2.49628675
83Diaphragmatic weakness (HP:0009113)2.49405084
84Hydroxyprolinuria (HP:0003080)2.48499147
85Abnormality of proline metabolism (HP:0010907)2.48499147
86Spinal rigidity (HP:0003306)2.44219109
87Turricephaly (HP:0000262)2.43950541
88Neonatal onset (HP:0003623)2.41029797
89Proximal tubulopathy (HP:0000114)2.40674305
90Axonal loss (HP:0003447)2.40351898
91Hepatocellular carcinoma (HP:0001402)2.39016866
92Broad face (HP:0000283)2.38293723
93* Vomiting (HP:0002013)2.35149114
94Thoracic kyphosis (HP:0002942)2.33653185
95Irritability (HP:0000737)2.31668063
96Neck muscle weakness (HP:0000467)2.30404474
97Cervical subluxation (HP:0003308)2.28559181
98Easy fatigability (HP:0003388)2.28408064
99Abnormality of the thoracic spine (HP:0100711)2.26868370
100Difficulty running (HP:0009046)2.26797888
101Reticulocytosis (HP:0001923)2.24995467
102Cholelithiasis (HP:0001081)2.24407843
103Alkalosis (HP:0001948)2.24208879
104Abnormality of the calf musculature (HP:0001430)2.23354750
105Spontaneous abortion (HP:0005268)2.23346696
106Cardiovascular calcification (HP:0011915)2.23183203
107Spastic diplegia (HP:0001264)2.22516050
108Thin bony cortex (HP:0002753)2.21380248
109Abnormal gallbladder morphology (HP:0012437)2.20784579
110Abnormality of the Achilles tendon (HP:0005109)2.18767978
111Ulnar bowing (HP:0003031)2.17903899
112Late onset (HP:0003584)2.16347871
113Abnormal gallbladder physiology (HP:0012438)2.15427669
114Cholecystitis (HP:0001082)2.15427669
115Alopecia of scalp (HP:0002293)2.14252544
116Bundle branch block (HP:0011710)2.13060513
117J-shaped sella turcica (HP:0002680)2.12488963
118Hypoglycemic seizures (HP:0002173)2.11904184
119Sensorimotor neuropathy (HP:0007141)2.10324204
120Upper limb amyotrophy (HP:0009129)2.10171425
121Distal upper limb amyotrophy (HP:0007149)2.10171425
122Rhabdomyolysis (HP:0003201)2.09890583
123Systemic lupus erythematosus (HP:0002725)2.09842186
124Ragged-red muscle fibers (HP:0003200)2.08471565
125Round ear (HP:0100830)2.08368335
126Pancreatitis (HP:0001733)2.07783795
127Achilles tendon contracture (HP:0001771)2.04218030
128Exercise-induced myalgia (HP:0003738)2.03762149
129Lymphangioma (HP:0100764)2.01929366
130Exercise-induced muscle cramps (HP:0003710)2.01095403
131Enlarged kidneys (HP:0000105)2.00066999
132Muscle hypertrophy of the lower extremities (HP:0008968)1.99697697
133Esophageal varix (HP:0002040)1.98099105
134Scapular winging (HP:0003691)1.97111847
135Polycythemia (HP:0001901)1.96580255
136Acute hepatic failure (HP:0006554)1.94223715
137Metaphyseal cupping (HP:0003021)1.93954168
138Rickets (HP:0002748)1.93868693
139Hyperacusis (HP:0010780)1.93551268
140Lower limb amyotrophy (HP:0007210)1.93002432
141Ventricular fibrillation (HP:0001663)1.92979462
142Hemorrhage of the eye (HP:0011885)1.92902943
143Brushfield spots (HP:0001088)1.92104087
144Opisthotonus (HP:0002179)1.91854571
145Foot dorsiflexor weakness (HP:0009027)1.89928281
146Abnormal atrioventricular conduction (HP:0005150)1.88090949
147Hyperinsulinemic hypoglycemia (HP:0000825)1.87908169
148Nephritis (HP:0000123)1.87431086
149Abnormal cartilage morphology (HP:0002763)1.87228141
150Hypertriglyceridemia (HP:0002155)1.87213102
151Glycosuria (HP:0003076)1.87045028
152Abnormality of urine glucose concentration (HP:0011016)1.87045028
153Calf muscle hypertrophy (HP:0008981)1.85341364
154Abnormal enzyme/coenzyme activity (HP:0012379)1.84656360
155Nausea (HP:0002018)1.84488366
156Mitral stenosis (HP:0001718)1.83622620
157Amyloidosis (HP:0011034)1.81256011
158Renal cortical cysts (HP:0000803)1.80788721
159EMG: neuropathic changes (HP:0003445)1.80186348
160Aneurysm (HP:0002617)1.79087551
161Ventricular arrhythmia (HP:0004308)1.78467661
162Advanced eruption of teeth (HP:0006288)1.77427625
163Dilated cardiomyopathy (HP:0001644)1.76280822
164Abnormality of the foot musculature (HP:0001436)1.75371381
165Abnormality of the gallbladder (HP:0005264)1.73712595
166Nuclear cataract (HP:0100018)1.71188274
167Status epilepticus (HP:0002133)1.71105158
168Ulnar deviation of the wrist (HP:0003049)1.69747257
169Protrusio acetabuli (HP:0003179)1.69541000
170Heart block (HP:0012722)1.68010019
171Disproportionate tall stature (HP:0001519)1.67558371
172Generalized amyotrophy (HP:0003700)1.64968691
173Onion bulb formation (HP:0003383)1.64282329
174Dysostosis multiplex (HP:0000943)1.63722062
175Biconcave vertebral bodies (HP:0004586)1.62391975
176Neonatal death (HP:0003811)1.62317926
177Syncope (HP:0001279)1.60984581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.68592611
2ICK3.55998456
3SIK13.37546679
4MAPK153.07882391
5PINK13.02160606
6FGFR42.82302941
7ERN12.73525439
8EPHA22.73410011
9TRIB32.68009782
10EEF2K2.34932150
11MAP3K62.30148426
12PDK42.25915602
13PDK32.25915602
14DDR22.07701163
15IRAK31.86264878
16MAP3K111.84719302
17MAPK111.72470231
18INSRR1.66744787
19SMG11.66719113
20PHKG21.61252766
21PHKG11.61252766
22RIPK11.51510901
23WNK41.50045999
24LATS11.47601878
25TYRO31.45597384
26ERBB41.43384019
27PDGFRA1.40639773
28DYRK1B1.40477012
29MST1R1.39419848
30STK38L1.35950770
31PDK21.34815219
32CAMK1D1.33993203
33PRKAA21.32161647
34PRPF4B1.31219550
35WNK31.28684335
36TNK21.28281995
37PKN21.26422793
38TAOK11.25398795
39MAP3K11.24428476
40MARK21.23906693
41CSK1.22445166
42MAP2K41.14492126
43BMX1.13975379
44MAP3K131.13813978
45PRKAA11.12996329
46FGFR21.10839348
47TESK11.09819453
48GSK3A1.07549604
49NME21.04851685
50MARK31.03996437
51LATS20.97316571
52PRKD20.95920587
53CDK60.94219038
54FGR0.93811431
55MATK0.93807124
56KSR20.93664220
57MAP3K70.92675203
58OXSR10.90682601
59STK380.87597089
60CDK120.84716100
61DAPK20.84655962
62EPHB10.84580744
63FLT30.84121516
64LMTK20.83853850
65MUSK0.82461139
66DMPK0.82192842
67TIE10.81455878
68PTK60.81421343
69MAP3K30.79802330
70CAMK2G0.79749539
71RIPK40.79004626
72TTN0.78595142
73PIK3CG0.77611000
74CAMK1G0.77299437
75DAPK10.74275881
76RPS6KA20.74020645
77JAK20.72737796
78TBK10.72678714
79MTOR0.69720123
80MET0.69285783
81MAPK40.68444842
82PRKG20.68410637
83MAP3K100.68380125
84ZAP700.68204766
85PAK40.67772978
86PRKACG0.67763032
87PRKCZ0.67613505
88TAOK30.67593077
89NME10.67431693
90PRKD30.66478632
91OBSCN0.65308272
92BLK0.64487633
93MAP4K10.62738794
94MAP2K30.61539995
95ABL20.61298054
96NEK10.61156325
97MAPK120.59912409
98PTK20.59837232
99ARAF0.56711846
100KDR0.55590783
101IRAK20.53868393
102CDC42BPA0.53847766
103TYK20.53611721
104PDPK10.53208556
105PRKD10.52769165
106RET0.51681520
107ERBB20.51055101
108SGK30.49675812
109PDK10.49531122
110MAP3K20.49431839
111MYLK0.48908338
112TAOK20.48493873
113FGFR30.46854458
114RPS6KL10.44730180
115RPS6KC10.44730180
116NEK20.44652483
117ROCK10.44098994
118TGFBR20.42636950
119STK390.40119077
120MAP3K80.38886009
121RPS6KA10.38276016
122GRK60.36486492
123MAPK70.36352235
124JAK30.36121680
125RPS6KA60.36076014
126MAP2K60.35208489
127MAPKAPK20.33240059
128JAK10.33148255
129FER0.33050520
130HIPK20.32667112
131MAP2K10.32569833
132AKT30.31628200
133SGK2230.31570568
134SGK4940.31570568
135MAPKAPK30.31064597
136PDGFRB0.29998045
137EGFR0.29418028
138CAMK40.28918779
139TRPM70.28499653
140NEK90.27933587
141PAK30.27873106

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.83622110
2Nitrogen metabolism_Homo sapiens_hsa009103.17279160
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.14530150
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.96144299
5Fatty acid degradation_Homo sapiens_hsa000712.93013445
6Arginine biosynthesis_Homo sapiens_hsa002202.84668375
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.76735946
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.75434364
9Other glycan degradation_Homo sapiens_hsa005112.70384111
10Propanoate metabolism_Homo sapiens_hsa006402.66528020
11Tryptophan metabolism_Homo sapiens_hsa003802.56200491
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56074162
13Fatty acid metabolism_Homo sapiens_hsa012122.54244007
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.37936169
15Butanoate metabolism_Homo sapiens_hsa006502.34111595
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.27846042
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23488097
18PPAR signaling pathway_Homo sapiens_hsa033202.19923647
19Complement and coagulation cascades_Homo sapiens_hsa046102.12432904
20Peroxisome_Homo sapiens_hsa041462.10619207
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.84120301
22Pyruvate metabolism_Homo sapiens_hsa006201.79513903
23Fatty acid biosynthesis_Homo sapiens_hsa000611.79054400
24beta-Alanine metabolism_Homo sapiens_hsa004101.77882635
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68666401
26Chemical carcinogenesis_Homo sapiens_hsa052041.63947792
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63279828
28Fatty acid elongation_Homo sapiens_hsa000621.61657740
29Histidine metabolism_Homo sapiens_hsa003401.56089538
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55701391
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.53395893
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50554266
33Caffeine metabolism_Homo sapiens_hsa002321.49043411
34Carbon metabolism_Homo sapiens_hsa012001.48468216
35Bile secretion_Homo sapiens_hsa049761.46864660
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44373289
37Biosynthesis of amino acids_Homo sapiens_hsa012301.42901032
38Phenylalanine metabolism_Homo sapiens_hsa003601.42767432
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38727154
40Retinol metabolism_Homo sapiens_hsa008301.38150264
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36440707
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.33375494
43Selenocompound metabolism_Homo sapiens_hsa004501.29985319
44Starch and sucrose metabolism_Homo sapiens_hsa005001.29254182
45Tyrosine metabolism_Homo sapiens_hsa003501.22228991
46VEGF signaling pathway_Homo sapiens_hsa043701.21434211
47Staphylococcus aureus infection_Homo sapiens_hsa051501.21288214
48Notch signaling pathway_Homo sapiens_hsa043301.19621799
49Sulfur metabolism_Homo sapiens_hsa009201.18531775
50Arginine and proline metabolism_Homo sapiens_hsa003301.18037104
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.17703349
52Dilated cardiomyopathy_Homo sapiens_hsa054141.17578549
53ABC transporters_Homo sapiens_hsa020101.14195594
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14165677
55Fat digestion and absorption_Homo sapiens_hsa049751.11448265
56Folate biosynthesis_Homo sapiens_hsa007901.09596035
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.08592841
58Acute myeloid leukemia_Homo sapiens_hsa052211.07452572
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03784664
60Lysine degradation_Homo sapiens_hsa003101.03390559
61Sulfur relay system_Homo sapiens_hsa041221.00028490
62Glycerolipid metabolism_Homo sapiens_hsa005610.94170666
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89053930
64Focal adhesion_Homo sapiens_hsa045100.87335178
65Steroid biosynthesis_Homo sapiens_hsa001000.87292561
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86183295
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83159600
68Vitamin digestion and absorption_Homo sapiens_hsa049770.80519108
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77633866
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.76054405
71ECM-receptor interaction_Homo sapiens_hsa045120.74051314
72Vitamin B6 metabolism_Homo sapiens_hsa007500.73459396
73Amoebiasis_Homo sapiens_hsa051460.69727669
74Pertussis_Homo sapiens_hsa051330.67446649
75GnRH signaling pathway_Homo sapiens_hsa049120.67215346
76mTOR signaling pathway_Homo sapiens_hsa041500.66627341
77Chronic myeloid leukemia_Homo sapiens_hsa052200.61051631
78* Glutathione metabolism_Homo sapiens_hsa004800.60542233
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60367540
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.59498542
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58280941
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.57302134
83Pentose phosphate pathway_Homo sapiens_hsa000300.56528049
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56328992
85Fructose and mannose metabolism_Homo sapiens_hsa000510.53816958
86Hepatitis C_Homo sapiens_hsa051600.53213160
87Lysosome_Homo sapiens_hsa041420.52715277
88Osteoclast differentiation_Homo sapiens_hsa043800.52445330
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50191864
90Metabolic pathways_Homo sapiens_hsa011000.48182403
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47152619
92Choline metabolism in cancer_Homo sapiens_hsa052310.46890426
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.45721154
94Gap junction_Homo sapiens_hsa045400.44370197
95Endometrial cancer_Homo sapiens_hsa052130.42290020
96Estrogen signaling pathway_Homo sapiens_hsa049150.41588938
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41375581
98Tight junction_Homo sapiens_hsa045300.41091418
99Apoptosis_Homo sapiens_hsa042100.40751357
100Prolactin signaling pathway_Homo sapiens_hsa049170.39489714
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38859674
102Non-small cell lung cancer_Homo sapiens_hsa052230.38346350
103Type II diabetes mellitus_Homo sapiens_hsa049300.37227465
104Insulin resistance_Homo sapiens_hsa049310.37108684
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.36170185
106HIF-1 signaling pathway_Homo sapiens_hsa040660.36169861
107ErbB signaling pathway_Homo sapiens_hsa040120.35939583
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.35501979
109Thyroid cancer_Homo sapiens_hsa052160.35435335
110TNF signaling pathway_Homo sapiens_hsa046680.34998250
111Galactose metabolism_Homo sapiens_hsa000520.34902484
112Glucagon signaling pathway_Homo sapiens_hsa049220.33557430
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33218965
114AMPK signaling pathway_Homo sapiens_hsa041520.30386891
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.27001794
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26043044
117One carbon pool by folate_Homo sapiens_hsa006700.24571837
118Linoleic acid metabolism_Homo sapiens_hsa005910.20332899
119Prion diseases_Homo sapiens_hsa050200.19884187
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18129030
121Insulin signaling pathway_Homo sapiens_hsa049100.13329053
122Circadian rhythm_Homo sapiens_hsa047100.11870999
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.04235887
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.01161858
125Renin-angiotensin system_Homo sapiens_hsa04614-0.1580529
126Alzheimers disease_Homo sapiens_hsa05010-0.1547559
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1493535
128Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1307605
129Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1296161
130Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1271747
131Parkinsons disease_Homo sapiens_hsa05012-0.1207221
132Bladder cancer_Homo sapiens_hsa05219-0.1152156
133Protein digestion and absorption_Homo sapiens_hsa04974-0.1093615
134Cardiac muscle contraction_Homo sapiens_hsa04260-0.0995168
135Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0864583
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0784540
137Oxidative phosphorylation_Homo sapiens_hsa00190-0.0691963
138Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0399912
139Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0359801
140Mineral absorption_Homo sapiens_hsa04978-0.0104739
141Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0079657

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