OPN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.35505831
2polyketide metabolic process (GO:0030638)6.35505831
3doxorubicin metabolic process (GO:0044598)6.35505831
4aminoglycoside antibiotic metabolic process (GO:0030647)5.70317973
5opioid receptor signaling pathway (GO:0038003)5.23896935
6low-density lipoprotein particle clearance (GO:0034383)5.13973826
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.68695466
8regulation of somitogenesis (GO:0014807)4.47604311
9pyrimidine-containing compound salvage (GO:0008655)4.35706816
10pyrimidine nucleoside salvage (GO:0043097)4.35706816
11response to peptidoglycan (GO:0032494)4.27827521
12pentose-phosphate shunt (GO:0006098)4.11909793
13nucleoside salvage (GO:0043174)3.94175370
14neuronal action potential propagation (GO:0019227)3.82167245
15nucleotide salvage (GO:0043173)3.78837717
16NADPH regeneration (GO:0006740)3.75838647
17neutrophil activation involved in immune response (GO:0002283)3.71890359
18membrane raft organization (GO:0031579)3.69732408
19glycoside metabolic process (GO:0016137)3.69190042
20negative regulation of cAMP-mediated signaling (GO:0043951)3.68849713
21urinary tract smooth muscle contraction (GO:0014848)3.64219233
22xenobiotic catabolic process (GO:0042178)3.57517017
23pinocytosis (GO:0006907)3.55783401
24positive regulation of vesicle fusion (GO:0031340)3.54918260
25positive regulation of mitochondrial membrane permeability (GO:0035794)3.49217053
26glycosphingolipid catabolic process (GO:0046479)3.45685342
27diaphragm development (GO:0060539)3.45403810
28regulation of cAMP-dependent protein kinase activity (GO:2000479)3.34829529
29negative regulation of metanephros development (GO:0072217)3.32486879
30purine nucleotide salvage (GO:0032261)3.28740015
31regulation of germinal center formation (GO:0002634)3.25692143
32misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.24796594
33response to pheromone (GO:0019236)3.24037284
34negative regulation of systemic arterial blood pressure (GO:0003085)3.23639433
35triglyceride catabolic process (GO:0019433)3.23167448
36cell adhesion mediated by integrin (GO:0033627)3.21590658
37cyclooxygenase pathway (GO:0019371)3.20310559
38protein retention in ER lumen (GO:0006621)3.19001193
39progesterone metabolic process (GO:0042448)3.16454051
40relaxation of cardiac muscle (GO:0055119)3.16056031
41skeletal muscle organ development (GO:0060538)3.15382222
42skeletal muscle fiber development (GO:0048741)3.15225224
43brown fat cell differentiation (GO:0050873)3.14931061
44heart contraction (GO:0060047)3.14818841
45heart process (GO:0003015)3.14818841
46oligosaccharide catabolic process (GO:0009313)3.13525548
47peptidyl-proline hydroxylation (GO:0019511)3.11106526
48mitochondrial genome maintenance (GO:0000002)3.10818840
49protein localization to synapse (GO:0035418)3.10246603
50hyaluronan catabolic process (GO:0030214)3.10116738
51glutamate secretion (GO:0014047)3.09760520
52glycolipid catabolic process (GO:0019377)3.09723063
53acylglycerol catabolic process (GO:0046464)3.08385679
54neutral lipid catabolic process (GO:0046461)3.08385679
55glomerular basement membrane development (GO:0032836)3.07334811
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07024356
57negative regulation of fatty acid biosynthetic process (GO:0045717)3.05874269
58heparin biosynthetic process (GO:0030210)3.05647808
59heparin metabolic process (GO:0030202)3.05647808
60cerebellar Purkinje cell differentiation (GO:0021702)3.04808362
61positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.04562312
62mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.04562312
63negative regulation of amino acid transport (GO:0051956)3.02611980
64maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.02522977
65negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.01368096
66regulation of female gonad development (GO:2000194)2.99578023
67positive regulation of male gonad development (GO:2000020)2.96715100
68positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.94489488
69regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.92503243
70positive regulation of cardiac muscle hypertrophy (GO:0010613)2.92475814
71positive regulation of muscle hypertrophy (GO:0014742)2.92475814
72negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.91555750
73white fat cell differentiation (GO:0050872)2.87175360
74glucose catabolic process (GO:0006007)2.86200084
75negative regulation of response to reactive oxygen species (GO:1901032)2.85738016
76behavioral response to cocaine (GO:0048148)2.85670088
77hemoglobin metabolic process (GO:0020027)2.85646112
78retinal metabolic process (GO:0042574)2.85642892
79hemidesmosome assembly (GO:0031581)2.85123627
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.84364530
81L-phenylalanine metabolic process (GO:0006558)2.84364530
82regulation of vesicle fusion (GO:0031338)2.81872416
83negative regulation of myeloid cell apoptotic process (GO:0033033)2.79675620
84positive regulation of macrophage cytokine production (GO:0060907)2.78477860
852-deoxyribonucleotide biosynthetic process (GO:0009265)2.77618400
86deoxyribose phosphate biosynthetic process (GO:0046385)2.77618400
87regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77578946
88positive regulation of odontogenesis (GO:0042482)2.76018935
89regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.75250938
90negative regulation of interleukin-17 production (GO:0032700)2.73923956
91pentose metabolic process (GO:0019321)2.73322374
92mucosal-associated lymphoid tissue development (GO:0048537)2.72853194
93Peyers patch development (GO:0048541)2.72853194
94lipopolysaccharide-mediated signaling pathway (GO:0031663)2.72236596
95pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.69050304
96negative regulation of phagocytosis (GO:0050765)2.68880193
97response to nitrosative stress (GO:0051409)2.67025199
98mature B cell differentiation involved in immune response (GO:0002313)2.66806974
99gamma-aminobutyric acid transport (GO:0015812)2.66138152
100positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.65384154
101heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.64324775
102neutrophil mediated immunity (GO:0002446)2.63929374
103negative regulation of calcium ion transport into cytosol (GO:0010523)2.63811663
104regulation of sequestering of triglyceride (GO:0010889)2.62962058
105nucleobase-containing small molecule interconversion (GO:0015949)2.62729356
106epithelial cell differentiation involved in kidney development (GO:0035850)2.62335632
107negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.61899839
108positive regulation of glomerulus development (GO:0090193)2.61149698
109negative regulation of fibrinolysis (GO:0051918)2.59682077
110synaptic vesicle exocytosis (GO:0016079)2.59638286
111neuron remodeling (GO:0016322)2.58950578
112cellular glucuronidation (GO:0052695)2.58767896
113negative regulation of interleukin-8 production (GO:0032717)2.58645658
114regulation of vitamin metabolic process (GO:0030656)2.58532842
115regulation of glycogen (starch) synthase activity (GO:2000465)2.57911222
116protein hydroxylation (GO:0018126)2.57440518
117ceramide catabolic process (GO:0046514)2.57307353
118activation of protein kinase A activity (GO:0034199)2.56589073
119negative regulation of nitric oxide biosynthetic process (GO:0045019)2.55611132
120regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.55197582
121positive regulation of tissue remodeling (GO:0034105)2.54877365
122regulation of NFAT protein import into nucleus (GO:0051532)2.54145131
123pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.53751806
124positive regulation of axon extension (GO:0045773)2.51435546
125positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.48910975
126negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.48123236
127pyrimidine ribonucleoside catabolic process (GO:0046133)2.47853531
128negative regulation of organic acid transport (GO:0032891)2.46921691
129membrane depolarization during action potential (GO:0086010)2.46441690
130positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.45695304
131quinone metabolic process (GO:1901661)2.45163229
132regulation of hydrogen peroxide-induced cell death (GO:1903205)2.45046506
133negative regulation of synaptic transmission, GABAergic (GO:0032229)2.45024666
134fibrinolysis (GO:0042730)2.44537186
135valine metabolic process (GO:0006573)2.44504405
136response to vitamin E (GO:0033197)2.43498780
137cardiac myofibril assembly (GO:0055003)2.43129282
138positive regulation of myoblast differentiation (GO:0045663)2.43119821
139lipoprotein transport (GO:0042953)2.42883895
140regulation of mast cell degranulation (GO:0043304)2.42184227
141regulation of skeletal muscle contraction (GO:0014819)2.42123206
142alkaloid metabolic process (GO:0009820)2.40997355
143positive regulation of nitric-oxide synthase activity (GO:0051000)2.40913611
144positive regulation of mast cell degranulation (GO:0043306)2.40893227
145positive regulation of mast cell activation involved in immune response (GO:0033008)2.40893227
146uronic acid metabolic process (GO:0006063)2.40816480
147glucuronate metabolic process (GO:0019585)2.40816480
148proline transport (GO:0015824)2.40455921
149positive regulation of DNA recombination (GO:0045911)2.40321981
150positive regulation of endothelial cell apoptotic process (GO:2000353)2.40178983
151endodermal cell differentiation (GO:0035987)2.40032628
152urea metabolic process (GO:0019627)2.39681441
153fatty acid transmembrane transport (GO:1902001)2.37266890
154erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.35848932
155L-phenylalanine catabolic process (GO:0006559)2.35848932
156sphingosine metabolic process (GO:0006670)2.35256376
157relaxation of muscle (GO:0090075)2.34795736
158deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.34329889
159short-chain fatty acid metabolic process (GO:0046459)2.34187710
160regulation of Golgi to plasma membrane protein transport (GO:0042996)2.33711163
161regulation of macrophage cytokine production (GO:0010935)2.33668841
162positive regulation of isotype switching (GO:0045830)2.32938402
163positive regulation of leukocyte degranulation (GO:0043302)2.32528777
164response to dietary excess (GO:0002021)2.31825213
165positive regulation of hemostasis (GO:1900048)2.31618241
166positive regulation of blood coagulation (GO:0030194)2.31618241
167positive regulation of cellular amine metabolic process (GO:0033240)2.30617872
168negative regulation of dendrite morphogenesis (GO:0050774)2.30188945
169cornea development in camera-type eye (GO:0061303)2.29953007
170urea cycle (GO:0000050)2.29659214
171regulation of transforming growth factor beta1 production (GO:0032908)2.27990763
172deoxyribose phosphate catabolic process (GO:0046386)2.27416140
173localization within membrane (GO:0051668)2.26547079
174regulation of gonadotropin secretion (GO:0032276)2.26312114
175cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.26061155
176positive regulation of interleukin-12 production (GO:0032735)2.25815998
177negative regulation of smooth muscle cell migration (GO:0014912)2.24845916
178positive regulation of coagulation (GO:0050820)2.24352796
179layer formation in cerebral cortex (GO:0021819)2.24271173
180vocalization behavior (GO:0071625)2.23988124
181response to laminar fluid shear stress (GO:0034616)2.23218014
182regulation of leukocyte degranulation (GO:0043300)2.22729675
183phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.22558358
184glomerulus development (GO:0032835)2.22128141
185neuron recognition (GO:0008038)2.21798142
186relaxation of smooth muscle (GO:0044557)2.21572825
187regulation of cholesterol storage (GO:0010885)2.21500231
188positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.21251184
189production of molecular mediator of immune response (GO:0002440)2.21093690
190regulation of metalloenzyme activity (GO:0048552)2.20845648
191regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.20563022
192alpha-linolenic acid metabolic process (GO:0036109)2.20466110
193nitrogen cycle metabolic process (GO:0071941)2.20295286
194C21-steroid hormone metabolic process (GO:0008207)2.19928344
195cytidine catabolic process (GO:0006216)2.19149377
196cytidine deamination (GO:0009972)2.19149377
197cytidine metabolic process (GO:0046087)2.19149377
198sleep (GO:0030431)2.18281956
199positive regulation of extracellular matrix organization (GO:1903055)2.18064682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.05289391
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.20120411
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.01131679
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.86598547
5GATA1_22025678_ChIP-Seq_K562_Human3.50130732
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.36715647
7CLOCK_20551151_ChIP-Seq_293T_Human3.26930868
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.04718071
9E2F7_22180533_ChIP-Seq_HELA_Human3.01170527
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.92379645
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.92215769
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.89339822
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.89319019
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51203741
15EZH2_22144423_ChIP-Seq_EOC_Human2.37368573
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.35722040
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.26817595
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.26284708
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25375036
20TAF15_26573619_Chip-Seq_HEK293_Human2.21000841
21RXR_22158963_ChIP-Seq_LIVER_Mouse2.12605895
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12571509
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.11519691
24VDR_21846776_ChIP-Seq_THP-1_Human2.06955999
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06216836
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.05918491
27VDR_24763502_ChIP-Seq_THP-1_Human2.05729678
28RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02812541
29EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02812541
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02662058
31GBX2_23144817_ChIP-Seq_PC3_Human2.01738539
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00366315
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00114123
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99126420
35* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.97725996
36* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.97725996
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.92844558
38AR_21572438_ChIP-Seq_LNCaP_Human1.89513135
39* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.86333906
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.85669680
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83341918
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79922450
43ZNF263_19887448_ChIP-Seq_K562_Human1.78352459
44* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.77346571
45SCL_19346495_ChIP-Seq_HPC-7_Human1.77135383
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.76938085
47IRF8_27001747_Chip-Seq_BMDM_Mouse1.76797287
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76185337
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75397989
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.73103712
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71780728
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.71530327
53* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70737577
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.69459665
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67051666
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.65064039
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.64112016
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.63359118
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57868633
60VDR_24787735_ChIP-Seq_THP-1_Human1.57156472
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55048947
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52747473
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51380379
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49742370
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49742370
66LXR_22158963_ChIP-Seq_LIVER_Mouse1.47837652
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46354752
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.45514679
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.43955002
70FUS_26573619_Chip-Seq_HEK293_Human1.41621174
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.41378886
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40817867
73* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39366421
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39254347
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.38365675
76EZH2_27294783_Chip-Seq_ESCs_Mouse1.37925305
77SPI1_23547873_ChIP-Seq_NB4_Human1.37751790
78CJUN_26792858_Chip-Seq_BT549_Human1.37717837
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37397571
80PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.37155877
81* SOX2_20726797_ChIP-Seq_SW620_Human1.34585785
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.34185637
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33275842
84MYC_18555785_ChIP-Seq_MESCs_Mouse1.33244836
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32983953
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32887020
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32449724
88* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31059344
89LXR_22292898_ChIP-Seq_THP-1_Human1.30113041
90* RACK7_27058665_Chip-Seq_MCF-7_Human1.30012120
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.29342065
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28956769
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28434064
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.26976232
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26644333
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26639175
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26096959
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.25612926
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24982285
100SMAD4_21799915_ChIP-Seq_A2780_Human1.23183088
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21841942
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20557167
103P300_19829295_ChIP-Seq_ESCs_Human1.20108238
104JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19696629
105AR_25329375_ChIP-Seq_VCAP_Human1.19661130
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19224234
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19220971
108RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18845196
109* UBF1/2_26484160_Chip-Seq_HMECs_Human1.18537329
110RUNX1_22412390_ChIP-Seq_EML_Mouse1.18410043
111ATF3_27146783_Chip-Seq_COLON_Human1.17897231
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17249241
113* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16949066
114REST_21632747_ChIP-Seq_MESCs_Mouse1.16494236
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16460560
116CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13802587
117RARB_27405468_Chip-Seq_BRAIN_Mouse1.12499698
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12325013
119* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11594973
120LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11517965
121TP53_18474530_ChIP-ChIP_U2OS_Human1.11012212
122* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10906151
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10676583
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10424437
125* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10003091
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07709658
127P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07552822
128TCF4_18268006_ChIP-ChIP_LS174T_Human1.07267561
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07169076
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06855229
131CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05948622
132ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05856901
133* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05582992
134PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04786021
135IRF8_22096565_ChIP-ChIP_GC-B_Human1.04236405
136NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04162410
137TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04090218
138SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03436130
139SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02920822
140* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02559059
141TFEB_21752829_ChIP-Seq_HELA_Human1.01961144
142POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01144137
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00774108
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00683302
145RING1B_27294783_Chip-Seq_ESCs_Mouse1.00269802
146ESR1_21235772_ChIP-Seq_MCF-7_Human1.00245644
147FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99706490
148EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99341628
149STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98532526
150PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98474025
151AHR_22903824_ChIP-Seq_MCF-7_Human0.98052987
152GF1B_26923725_Chip-Seq_HPCs_Mouse0.97654582
153TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97337684
154LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97292555
155NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97090126
156AR_21909140_ChIP-Seq_LNCAP_Human0.97038561
157ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96976486
158JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96879689
159HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96837754
160TBX20_22328084_ChIP-Seq_HEART_Mouse0.96673813
161TBX20_22080862_ChIP-Seq_HEART_Mouse0.96673813
162UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96653708
163RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94764105
164PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94616419
165* NCOR1_26117541_ChIP-Seq_K562_Human0.94470990
166TP53_20018659_ChIP-ChIP_R1E_Mouse0.93463090
167CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92898703
168TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92412356
169GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92177234
170RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91347087
171GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90908597
172KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90508232
173REST_18959480_ChIP-ChIP_MESCs_Mouse0.90295397
174PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90265651
175GATA4_25053715_ChIP-Seq_YYC3_Human0.90085442
176FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89812665
177ZNF274_21170338_ChIP-Seq_K562_Hela0.89610524
178NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89459969
179AR_19668381_ChIP-Seq_PC3_Human0.89023469
180OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88825338
181KLF5_25053715_ChIP-Seq_YYC3_Human0.87882588
182* KDM2B_26808549_Chip-Seq_K562_Human0.87318613
183KDM2B_26808549_Chip-Seq_REH_Human0.87221707
184ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85624600
185ARNT_22903824_ChIP-Seq_MCF-7_Human0.85508394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.13268726
2MP0005058_abnormal_lysosome_morphology3.93678720
3MP0009780_abnormal_chondrocyte_physiolo3.93292763
4MP0003806_abnormal_nucleotide_metabolis3.41421382
5MP0002876_abnormal_thyroid_physiology2.99398771
6MP0001501_abnormal_sleep_pattern2.96159061
7MP0006082_CNS_inflammation2.92859558
8MP0008961_abnormal_basal_metabolism2.89072772
9MP0002837_dystrophic_cardiac_calcinosis2.87644368
10MP0009046_muscle_twitch2.79978475
11MP0003191_abnormal_cellular_cholesterol2.68570124
12MP0005670_abnormal_white_adipose2.57012005
13MP0009278_abnormal_bone_marrow2.56820508
14MP0000003_abnormal_adipose_tissue2.47987606
15MP0002148_abnormal_hypersensitivity_rea2.46745704
16MP0003705_abnormal_hypodermis_morpholog2.43364877
17MP0009379_abnormal_foot_pigmentation2.34339913
18MP0000015_abnormal_ear_pigmentation2.30285389
19MP0004270_analgesia2.26306062
20MP0000013_abnormal_adipose_tissue2.22708285
21MP0003303_peritoneal_inflammation2.18378208
22MP0003172_abnormal_lysosome_physiology2.17266588
23MP0009840_abnormal_foam_cell2.13076898
24MP0003075_altered_response_to2.09885280
25MP0002160_abnormal_reproductive_system2.04906078
26MP0008438_abnormal_cutaneous_collagen2.04035562
27MP0003329_amyloid_beta_deposits2.02458538
28MP0001545_abnormal_hematopoietic_system2.00601192
29MP0005397_hematopoietic_system_phenotyp2.00601192
30MP0003646_muscle_fatigue1.94276829
31MP0003879_abnormal_hair_cell1.94276167
32MP0002419_abnormal_innate_immunity1.92418802
33MP0004510_myositis1.84422626
34MP0005023_abnormal_wound_healing1.84349021
35MP0005375_adipose_tissue_phenotype1.83254062
36MP0005464_abnormal_platelet_physiology1.83210812
37MP0005085_abnormal_gallbladder_physiolo1.81559718
38MP0003566_abnormal_cell_adhesion1.79758040
39MP0005451_abnormal_body_composition1.79267820
40MP0009785_altered_susceptibility_to1.75867735
41MP0009697_abnormal_copulation1.74824185
42MP0004272_abnormal_basement_membrane1.74255089
43MP0004130_abnormal_muscle_cell1.73052837
44MP0000858_altered_metastatic_potential1.70867016
45MP0005334_abnormal_fat_pad1.65886474
46MP0003315_abnormal_perineum_morphology1.65704224
47MP0005645_abnormal_hypothalamus_physiol1.65064394
48MP0002971_abnormal_brown_adipose1.62543008
49MP0003950_abnormal_plasma_membrane1.62503067
50MP0003635_abnormal_synaptic_transmissio1.62365629
51MP0008260_abnormal_autophagy1.60466888
52MP0002734_abnormal_mechanical_nocicepti1.59784845
53MP0001853_heart_inflammation1.57953594
54MP0009333_abnormal_splenocyte_physiolog1.55592147
55MP0005666_abnormal_adipose_tissue1.53791687
56MP0002733_abnormal_thermal_nociception1.53474613
57MP0004185_abnormal_adipocyte_glucose1.52505653
58MP0000751_myopathy1.50730307
59MP0002272_abnormal_nervous_system1.50557297
60MP0003880_abnormal_central_pattern1.49353691
61MP0003252_abnormal_bile_duct1.49120613
62MP0005257_abnormal_intraocular_pressure1.48948560
63MP0005165_increased_susceptibility_to1.47369906
64MP0008875_abnormal_xenobiotic_pharmacok1.47087828
65MP0004859_abnormal_synaptic_plasticity1.46690589
66MP0001440_abnormal_grooming_behavior1.46038224
67MP0010386_abnormal_urinary_bladder1.45522243
68MP0003122_maternal_imprinting1.42905324
69MP0010329_abnormal_lipoprotein_level1.42490482
70MP0003183_abnormal_peptide_metabolism1.42263079
71MP0009745_abnormal_behavioral_response1.40412206
72MP0003300_gastrointestinal_ulcer1.39189794
73MP0002972_abnormal_cardiac_muscle1.38609102
74MP0001851_eye_inflammation1.35714360
75MP0003436_decreased_susceptibility_to1.32258936
76MP0001968_abnormal_touch/_nociception1.32164356
77MP0005025_abnormal_response_to1.31978745
78MP0005535_abnormal_body_temperature1.31938382
79MP0001502_abnormal_circadian_rhythm1.30929103
80MP0000749_muscle_degeneration1.30600202
81MP0001542_abnormal_bone_strength1.30555235
82MP0005166_decreased_susceptibility_to1.29914485
83MP0005365_abnormal_bile_salt1.29554730
84MP0000343_altered_response_to1.29039059
85MP0002396_abnormal_hematopoietic_system1.28413310
86MP0003656_abnormal_erythrocyte_physiolo1.28044925
87MP0008469_abnormal_protein_level1.27713754
88MP0003890_abnormal_embryonic-extraembry1.26953612
89MP0005076_abnormal_cell_differentiation1.26170459
90MP0004145_abnormal_muscle_electrophysio1.24949772
91MP0001881_abnormal_mammary_gland1.24883423
92MP0005410_abnormal_fertilization1.24343399
93MP0004264_abnormal_extraembryonic_tissu1.22967303
94MP0002452_abnormal_antigen_presenting1.22942230
95MP0005620_abnormal_muscle_contractility1.21999192
96MP0000604_amyloidosis1.21584171
97MP0002078_abnormal_glucose_homeostasis1.20871887
98MP0002060_abnormal_skin_morphology1.20746696
99MP0005000_abnormal_immune_tolerance1.20745340
100MP0003941_abnormal_skin_development1.20499024
101MP0005197_abnormal_uvea_morphology1.20215911
102MP0002063_abnormal_learning/memory/cond1.18160725
103MP0004883_abnormal_blood_vessel1.18112851
104MP0003186_abnormal_redox_activity1.17949307
105MP0003123_paternal_imprinting1.17165699
106MP0003448_altered_tumor_morphology1.17121876
107MP0002572_abnormal_emotion/affect_behav1.16302723
108MP0002138_abnormal_hepatobiliary_system1.16089178
109MP0002064_seizures1.15034193
110MP0005319_abnormal_enzyme/_coenzyme1.13008145
111MP0004484_altered_response_of1.12793867
112MP0003453_abnormal_keratinocyte_physiol1.12696315
113MP0002909_abnormal_adrenal_gland1.12081403
114MP0009115_abnormal_fat_cell1.11914606
115MP0003828_pulmonary_edema1.09646811
116MP0008877_abnormal_DNA_methylation1.08525210
117MP0002735_abnormal_chemical_nociception1.04603179
118MP0002067_abnormal_sensory_capabilities1.04353605
119MP0009384_cardiac_valve_regurgitation1.04254499
120MP0002089_abnormal_postnatal_growth/wei1.04216950
121MP0002693_abnormal_pancreas_physiology1.04168016
122MP0005385_cardiovascular_system_phenoty1.01545859
123MP0001544_abnormal_cardiovascular_syste1.01545859
124MP0005584_abnormal_enzyme/coenzyme_acti1.00025396
125MP0001764_abnormal_homeostasis0.99808512
126MP0002896_abnormal_bone_mineralization0.99055115
127MP0000681_abnormal_thyroid_gland0.98330566
128MP0001845_abnormal_inflammatory_respons0.98203953
129MP0004924_abnormal_behavior0.96477488
130MP0005386_behavior/neurological_phenoty0.96477488
131MP0005332_abnormal_amino_acid0.95963667
132MP0002970_abnormal_white_adipose0.95730679
133MP0004947_skin_inflammation0.95674816
134MP0003221_abnormal_cardiomyocyte_apopto0.94879972
135MP0003959_abnormal_lean_body0.94687184
136MP0003195_calcinosis0.93709450
137MP0004087_abnormal_muscle_fiber0.93417947
138MP0003724_increased_susceptibility_to0.92687458
139MP0004808_abnormal_hematopoietic_stem0.91613072
140MP0002254_reproductive_system_inflammat0.91508042
141MP0002723_abnormal_immune_serum0.91365162
142MP0000685_abnormal_immune_system0.91209543
143MP0005387_immune_system_phenotype0.90996613
144MP0001790_abnormal_immune_system0.90996613
145MP0006276_abnormal_autonomic_nervous0.89634157
146MP0001819_abnormal_immune_cell0.89231251
147MP0002420_abnormal_adaptive_immunity0.89145370
148MP0003091_abnormal_cell_migration0.88449464
149MP0004233_abnormal_muscle_weight0.88427335
150MP0000639_abnormal_adrenal_gland0.88317791
151MP0000767_abnormal_smooth_muscle0.87867610
152MP0004858_abnormal_nervous_system0.87303281
153MP0002877_abnormal_melanocyte_morpholog0.86592169
154MP0005501_abnormal_skin_physiology0.86489137
155MP0002557_abnormal_social/conspecific_i0.86181851
156MP0001835_abnormal_antigen_presentation0.85976904
157MP0001970_abnormal_pain_threshold0.85785358
158MP0005360_urolithiasis0.85116174
159MP0005408_hypopigmentation0.85048721
160MP0005448_abnormal_energy_balance0.84844297
161MP0008569_lethality_at_weaning0.84103768
162MP0005389_reproductive_system_phenotype0.84098726
163MP0002998_abnormal_bone_remodeling0.83999163
164MP0002118_abnormal_lipid_homeostasis0.83603484
165MP0000490_abnormal_crypts_of0.83415953
166MP0010307_abnormal_tumor_latency0.82781743
167MP0009643_abnormal_urine_homeostasis0.82364318
168MP0005275_abnormal_skin_tensile0.82332043
169MP0001533_abnormal_skeleton_physiology0.82037666
170MP0005452_abnormal_adipose_tissue0.81517219
171MP0005164_abnormal_response_to0.81324351
172MP0009763_increased_sensitivity_to0.78244561
173MP0008873_increased_physiological_sensi0.77100318
174MP0010630_abnormal_cardiac_muscle0.76839296
175MP0000920_abnormal_myelination0.76754214
176MP0010352_gastrointestinal_tract_polyps0.75724583
177MP0005595_abnormal_vascular_smooth0.74656343
178MP0002133_abnormal_respiratory_system0.71513122
179MP0005388_respiratory_system_phenotype0.71513122
180MP0001800_abnormal_humoral_immune0.70465830
181MP0005193_abnormal_anterior_eye0.69839964

Predicted human phenotypes

RankGene SetZ-score
1Anomalous pulmonary venous return (HP:0010772)5.42820899
2Hyperventilation (HP:0002883)5.08005537
3Abnormality of glycolipid metabolism (HP:0010969)4.96190469
4Abnormality of liposaccharide metabolism (HP:0010968)4.96190469
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.96190469
6Abnormality of the pulmonary veins (HP:0011718)4.78634926
7Vacuolated lymphocytes (HP:0001922)4.02047690
8Vertebral compression fractures (HP:0002953)3.98176164
9Dry hair (HP:0011359)3.90593445
10Poor eye contact (HP:0000817)3.84610831
11Inappropriate behavior (HP:0000719)3.62450795
12Gonadal dysgenesis (HP:0000133)3.51402182
13Beaking of vertebral bodies (HP:0004568)3.37743437
14Dysostosis multiplex (HP:0000943)3.30029968
15Protrusio acetabuli (HP:0003179)3.15404130
16Oligomenorrhea (HP:0000876)3.07613689
17Abnormality of monocarboxylic acid metabolism (HP:0010996)3.07235013
18Neuroendocrine neoplasm (HP:0100634)3.01485706
19Right ventricular cardiomyopathy (HP:0011663)2.97825377
20Mediastinal lymphadenopathy (HP:0100721)2.96583433
21Urinary glycosaminoglycan excretion (HP:0003541)2.93545380
22Mucopolysacchariduria (HP:0008155)2.93545380
23Hypercortisolism (HP:0001578)2.93359132
24Disinhibition (HP:0000734)2.90587699
25Epileptiform EEG discharges (HP:0011182)2.89392440
26Impaired social interactions (HP:0000735)2.86079185
27Abnormal social behavior (HP:0012433)2.86079185
28Postural tremor (HP:0002174)2.85673966
29EEG with generalized epileptiform discharges (HP:0011198)2.84664691
30Testicular neoplasm (HP:0010788)2.84373597
31Mesangial abnormality (HP:0001966)2.84315458
32Pheochromocytoma (HP:0002666)2.82248390
33Epileptic encephalopathy (HP:0200134)2.81612370
34Spondylolisthesis (HP:0003302)2.78895576
35Amyloidosis (HP:0011034)2.78594607
36Protruding tongue (HP:0010808)2.77867613
37Abnormality of polysaccharide metabolism (HP:0011012)2.76037622
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.76037622
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.76037622
40Hyperglycemia (HP:0003074)2.75411163
41Progressive cerebellar ataxia (HP:0002073)2.71488626
42Diaphragmatic weakness (HP:0009113)2.66479608
43Hypsarrhythmia (HP:0002521)2.65262535
44Loss of speech (HP:0002371)2.65129341
45Abnormality of macrophages (HP:0004311)2.63181626
46Broad-based gait (HP:0002136)2.62433151
47Abnormality of the odontoid process (HP:0003310)2.60034725
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59864747
49Abnormality of alanine metabolism (HP:0010916)2.59864747
50Hyperalaninemia (HP:0003348)2.59864747
51Arterial tortuosity (HP:0005116)2.59177218
52Severe visual impairment (HP:0001141)2.58528561
53Myelomeningocele (HP:0002475)2.55074452
54Abnormality of the Achilles tendon (HP:0005109)2.54071282
55Hepatocellular necrosis (HP:0001404)2.53784833
56Thoracic kyphosis (HP:0002942)2.52184365
57Exotropia (HP:0000577)2.50427523
58Asymmetry of the thorax (HP:0001555)2.49177452
59Acrocyanosis (HP:0001063)2.48522018
60Atonic seizures (HP:0010819)2.45607717
61Proximal amyotrophy (HP:0007126)2.43088038
62Inability to walk (HP:0002540)2.42474489
63Focal motor seizures (HP:0011153)2.41651669
64Hypoplastic left heart (HP:0004383)2.41353622
65Progressive microcephaly (HP:0000253)2.39456256
66Fair hair (HP:0002286)2.38889600
67Clumsiness (HP:0002312)2.37709389
68Atrophic scars (HP:0001075)2.37621560
69Pseudobulbar signs (HP:0002200)2.37585143
70Fetal akinesia sequence (HP:0001989)2.36733015
71Ketoacidosis (HP:0001993)2.35308853
72Resting tremor (HP:0002322)2.34954300
73Hepatosplenomegaly (HP:0001433)2.34237196
74Generalized tonic-clonic seizures (HP:0002069)2.33832380
75J-shaped sella turcica (HP:0002680)2.32795316
76Achilles tendon contracture (HP:0001771)2.31335149
77Stridor (HP:0010307)2.30414109
78Cervical subluxation (HP:0003308)2.21979233
79Palpitations (HP:0001962)2.21169190
80Abnormality of the intervertebral disk (HP:0005108)2.20035960
81Shoulder girdle muscle weakness (HP:0003547)2.19259854
82Action tremor (HP:0002345)2.18792774
83Onycholysis (HP:0001806)2.17452141
84Vascular tortuosity (HP:0004948)2.17428674
85Systemic lupus erythematosus (HP:0002725)2.16719817
86Cerebral hemorrhage (HP:0001342)2.16160397
87Absent speech (HP:0001344)2.15851206
88Blue irides (HP:0000635)2.15813718
89Hepatic necrosis (HP:0002605)2.15506079
90Insulin-resistant diabetes mellitus (HP:0000831)2.14687630
91Increased cerebral lipofuscin (HP:0011813)2.14373190
92Prolonged neonatal jaundice (HP:0006579)2.13328493
93Visual hallucinations (HP:0002367)2.10501603
94Premature rupture of membranes (HP:0001788)2.10299566
95Hypoplastic heart (HP:0001961)2.09617689
96Polygenic inheritance (HP:0010982)2.09138661
97Recurrent gram-negative bacterial infections (HP:0005420)2.08022325
98Flat acetabular roof (HP:0003180)2.07312341
99Abnormality of the thoracic spine (HP:0100711)2.07004539
100Hypertriglyceridemia (HP:0002155)2.06819951
101Abnormality of aromatic amino acid family metabolism (HP:0004338)2.06583681
102Patent foramen ovale (HP:0001655)2.05279330
103Orthostatic hypotension (HP:0001278)2.04937411
104Xerostomia (HP:0000217)2.03300094
105Hemivertebrae (HP:0002937)2.03062230
106Absence seizures (HP:0002121)2.02392057
107Lower limb amyotrophy (HP:0007210)2.01963404
108Abnormality of the anterior horn cell (HP:0006802)2.01905233
109Degeneration of anterior horn cells (HP:0002398)2.01905233
110Hypokinesia (HP:0002375)2.01539258
111Sex reversal (HP:0012245)2.01492448
112Abnormal sex determination (HP:0012244)2.01492448
113Abnormal pancreas size (HP:0012094)2.00831929
114Syncope (HP:0001279)1.98123431
115Generalized hypopigmentation of hair (HP:0011358)1.97655800
116Deep venous thrombosis (HP:0002625)1.97378885
117Abnormality of the common coagulation pathway (HP:0010990)1.95873305
118Vascular calcification (HP:0004934)1.95665008
119Long toe (HP:0010511)1.95068659
120Distal upper limb amyotrophy (HP:0007149)1.95010368
121Upper limb amyotrophy (HP:0009129)1.95010368
122Generalized myoclonic seizures (HP:0002123)1.94830789
123Abnormality of the acetabulum (HP:0003170)1.92576576
124Focal seizures (HP:0007359)1.91289011
125Bifid tongue (HP:0010297)1.91024755
126Periodontitis (HP:0000704)1.90026689
127Bone cyst (HP:0012062)1.89988367
128Insulin resistance (HP:0000855)1.89951168
129Hematochezia (HP:0002573)1.89682177
130Cardiovascular calcification (HP:0011915)1.89343017
131Metaphyseal dysplasia (HP:0100255)1.89167099
132Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87199878
133Abnormality of the peritoneum (HP:0002585)1.86738268
134Acanthosis nigricans (HP:0000956)1.86253418
135Cardiomegaly (HP:0001640)1.85821525
136Abnormality of the calf musculature (HP:0001430)1.85099526
137Abnormality of the periventricular white matter (HP:0002518)1.84535998
138Striae distensae (HP:0001065)1.84331282
139Hyperthyroidism (HP:0000836)1.83870571
140Cerebral aneurysm (HP:0004944)1.83834549
141Albinism (HP:0001022)1.83634286
142Milia (HP:0001056)1.83280810
143Papillary thyroid carcinoma (HP:0002895)1.82748123
144Bone pain (HP:0002653)1.82599482
145Intellectual disability, profound (HP:0002187)1.82433403
146Glomerulosclerosis (HP:0000096)1.82120319
147Hypercholesterolemia (HP:0003124)1.81425324
148Multiple lipomas (HP:0001012)1.80756145
149Muscle stiffness (HP:0003552)1.80313626
150Tachypnea (HP:0002789)1.79905848
151Focal segmental glomerulosclerosis (HP:0000097)1.79671005
152Thoracolumbar scoliosis (HP:0002944)1.78923771
153Distal lower limb muscle weakness (HP:0009053)1.77901951
154Fatigue (HP:0012378)1.77555538
155Bulbar palsy (HP:0001283)1.75960948
156Abnormality of the lumbar spine (HP:0100712)1.75520233
157Myokymia (HP:0002411)1.75382993
158Increased neuronal autofluorescent lipopigment (HP:0002074)1.74848288
159Syringomyelia (HP:0003396)1.74644833
160Spinal cord lesions (HP:0100561)1.74644833
161Thrombocytosis (HP:0001894)1.74202427
162Increased serum ferritin (HP:0003281)1.74021010
163Thyroid carcinoma (HP:0002890)1.73083830
164Hyperphosphatemia (HP:0002905)1.72886835
165Upper motor neuron abnormality (HP:0002127)1.72819204
166Status epilepticus (HP:0002133)1.72377189
167Abnormality of glutamine family amino acid metabolism (HP:0010902)1.72091573
168Hand muscle atrophy (HP:0009130)1.71785834
169Myocardial infarction (HP:0001658)1.70668113
170Abnormality of complement system (HP:0005339)1.70561252
171Vertebral hypoplasia (HP:0008417)1.70450138
172Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.70450138
173Neoplasm of head and neck (HP:0012288)1.69671840
174Esophageal neoplasm (HP:0100751)1.69671840
175Weak cry (HP:0001612)1.68670257
176Nausea (HP:0002018)1.67983209
177Hyperammonemia (HP:0001987)1.66863623
178Abnormality of pyrimidine metabolism (HP:0004353)1.65668737
179Cheilitis (HP:0100825)1.65404405
180Recurrent abscess formation (HP:0002722)1.65019795
181Diminished motivation (HP:0000745)1.64646816
182Myoglobinuria (HP:0002913)1.64555225
183Generalized aminoaciduria (HP:0002909)1.64507526
184Conjugated hyperbilirubinemia (HP:0002908)1.64503129
185Increased connective tissue (HP:0009025)1.64456148
186Tinnitus (HP:0000360)1.63696279
187Meningocele (HP:0002435)1.62877416
188Sensorimotor neuropathy (HP:0007141)1.61813652
189Myotonia (HP:0002486)1.61398374
190Mitral stenosis (HP:0001718)1.61195023
191Cupped ribs (HP:0000887)1.60957975
192Osteomalacia (HP:0002749)1.60612096
193Abnormality of the vocal cords (HP:0008777)1.57074038
194Eczematoid dermatitis (HP:0000976)1.56709471

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR23.59234668
2FLT33.45224369
3RIPK13.31665209
4NME23.22855331
5MAP3K93.08358647
6CDK122.89898858
7SCYL22.87779457
8TRIB32.81488427
9RIPK42.50055650
10MAP3K132.48993302
11ARAF2.34700677
12MAP3K122.28800174
13IRAK32.28511604
14PRPF4B2.20957962
15LATS22.19346724
16TESK12.13465025
17MAP3K52.03226145
18DAPK21.96594308
19PBK1.91683573
20PTK2B1.89113796
21TAOK11.84105592
22EPHA41.80636429
23PLK21.78670476
24SIK11.74806221
25CAMKK21.73187146
26ERN11.72462552
27PIK3CG1.65411305
28MAP2K71.64630348
29FRK1.61610570
30CAMKK11.60027872
31MAP3K41.55883932
32TAOK21.55575251
33MAP3K101.53758906
34MYLK1.53373027
35MAP4K11.48801797
36PAK41.48652073
37MAP2K41.48345837
38EIF2AK31.47686635
39CSF1R1.46166679
40TGFBR21.45751721
41BLK1.43895271
42CASK1.42923091
43TBK11.41566952
44MET1.38307109
45NTRK11.32222917
46ERBB41.28148336
47BRAF1.26366835
48ERBB31.26041257
49MOS1.25261083
50MAP3K141.24669273
51CAMK1D1.24344183
52MINK11.22209550
53CCNB11.21518831
54TYK21.20772987
55MELK1.18597063
56MAP3K111.18005054
57EPHA21.15512779
58WNK31.13999589
59KSR21.07104703
60ZAK1.06816192
61MAP3K21.06626728
62ZAP701.04259369
63JAK31.02363384
64PASK0.98513384
65LIMK10.96836520
66PDK30.94205540
67PDK40.94205540
68GRK70.93155007
69BRD40.92051965
70STK100.91646246
71DAPK10.91225887
72MAPK130.91028752
73MATK0.87229774
74KIT0.84327171
75SIK20.81680308
76PAK60.81592244
77PDGFRA0.80694516
78MAP3K30.80501873
79MUSK0.79449044
80PRKD20.78946463
81MAP4K20.78760479
82MAP2K10.77257573
83DAPK30.73416954
84RPS6KA20.73038033
85MAP3K60.70902932
86CLK10.70027041
87KSR10.69253381
88EPHB20.68218742
89JAK20.68146695
90PTK20.67376055
91IKBKB0.66891924
92MAPK40.64886558
93BCKDK0.63919781
94DDR20.63843616
95RAF10.63350505
96CDK190.62421655
97ROCK10.60423623
98RET0.59281714
99CDC42BPA0.58940892
100PRKCD0.57735732
101MAP2K30.57456276
102LRRK20.57252907
103NEK90.57124311
104KDR0.56893409
105TRPM70.55706505
106ABL20.55091385
107CDC70.54111054
108CAMK1G0.53927164
109MAPK120.53090390
110NTRK30.51986051
111LMTK20.51677078
112FER0.51646317
113FGR0.49777444
114RPS6KL10.49470925
115RPS6KC10.49470925
116CDK80.48000343
117GRK60.47665077
118NEK10.46498619
119MARK10.46351102
120SGK10.45959886
121MAPKAPK50.44958326
122CDK60.44600549
123RPS6KB20.44311589
124EIF2AK10.43982735
125ITK0.43812670
126PIM20.42543334
127PRKG20.41907090
128MAPK110.41473820
129ROCK20.40841639
130PTK60.40336401
131PRKCG0.39429306
132PDPK10.39375790
133PRKCQ0.38494262
134CDK90.36799247
135TESK20.36679590
136GRK50.36323864
137STK380.35541793
138MARK30.35350331
139PDK10.35077202
140FES0.34752593
141DYRK1A0.34157013
142PAK10.34129997
143ILK0.34110943
144PLK30.33932594
145PKN20.33530826
146CDK40.31651835
147MAP3K10.31546920
148CAMK2A0.31455411
149CDK50.30558192
150CDK140.30004981
151ABL10.29257554
152SYK0.27613122
153TLK10.26751489
154MST1R0.25110372
155PDK20.23479797
156VRK10.23304715
157MAPK70.22258863

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.49531799
2Drug metabolism - other enzymes_Homo sapiens_hsa009833.24956702
3Pentose phosphate pathway_Homo sapiens_hsa000303.14355313
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.67170191
5Galactose metabolism_Homo sapiens_hsa000522.66083594
6Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.40757740
7Lysosome_Homo sapiens_hsa041422.36251387
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.28234416
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17019826
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.10655980
11Amphetamine addiction_Homo sapiens_hsa050312.00500609
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.98669178
13Complement and coagulation cascades_Homo sapiens_hsa046101.91704572
14Synaptic vesicle cycle_Homo sapiens_hsa047211.90976806
15Type II diabetes mellitus_Homo sapiens_hsa049301.89399218
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.83446071
17Long-term potentiation_Homo sapiens_hsa047201.78973778
18Fatty acid biosynthesis_Homo sapiens_hsa000611.76228693
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74179121
20PPAR signaling pathway_Homo sapiens_hsa033201.73231736
21Circadian entrainment_Homo sapiens_hsa047131.70463645
22Phenylalanine metabolism_Homo sapiens_hsa003601.69264170
23Glutathione metabolism_Homo sapiens_hsa004801.65754242
24Asthma_Homo sapiens_hsa053101.63698965
25Amoebiasis_Homo sapiens_hsa051461.61630359
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.60793313
27Renin secretion_Homo sapiens_hsa049241.60061561
28Fatty acid elongation_Homo sapiens_hsa000621.57964113
29Long-term depression_Homo sapiens_hsa047301.50362280
30Staphylococcus aureus infection_Homo sapiens_hsa051501.49211133
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46622071
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44667717
33Sulfur metabolism_Homo sapiens_hsa009201.44400407
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43684183
35Pertussis_Homo sapiens_hsa051331.42090980
36Dopaminergic synapse_Homo sapiens_hsa047281.41678149
37Fructose and mannose metabolism_Homo sapiens_hsa000511.41183336
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.40494082
39Insulin secretion_Homo sapiens_hsa049111.39794552
40Cocaine addiction_Homo sapiens_hsa050301.39073441
41Sphingolipid metabolism_Homo sapiens_hsa006001.36635656
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33960971
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.31335320
44Shigellosis_Homo sapiens_hsa051311.31113955
45Glucagon signaling pathway_Homo sapiens_hsa049221.30646183
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28141599
47ECM-receptor interaction_Homo sapiens_hsa045121.28011316
48Circadian rhythm_Homo sapiens_hsa047101.27451671
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27010609
50Serotonergic synapse_Homo sapiens_hsa047261.24507272
51Salivary secretion_Homo sapiens_hsa049701.23596329
52Estrogen signaling pathway_Homo sapiens_hsa049151.23511137
53Hematopoietic cell lineage_Homo sapiens_hsa046401.21290105
54Propanoate metabolism_Homo sapiens_hsa006401.20144152
55Oxytocin signaling pathway_Homo sapiens_hsa049211.17573652
56Glutamatergic synapse_Homo sapiens_hsa047241.16710672
57Collecting duct acid secretion_Homo sapiens_hsa049661.15370840
58GnRH signaling pathway_Homo sapiens_hsa049121.15228852
59Insulin signaling pathway_Homo sapiens_hsa049101.14724535
60Chemical carcinogenesis_Homo sapiens_hsa052041.12961734
61Pyruvate metabolism_Homo sapiens_hsa006201.11053001
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09300486
63Vibrio cholerae infection_Homo sapiens_hsa051101.09033515
64Intestinal immune network for IgA production_Homo sapiens_hsa046721.08874828
65Allograft rejection_Homo sapiens_hsa053301.07523420
66Cholinergic synapse_Homo sapiens_hsa047251.07094812
67Thyroid hormone synthesis_Homo sapiens_hsa049181.06807716
68Fatty acid metabolism_Homo sapiens_hsa012121.06599699
69Insulin resistance_Homo sapiens_hsa049311.05836173
70Adipocytokine signaling pathway_Homo sapiens_hsa049201.05027124
71Oocyte meiosis_Homo sapiens_hsa041141.04487986
72African trypanosomiasis_Homo sapiens_hsa051431.04078628
73Glycerolipid metabolism_Homo sapiens_hsa005611.02847454
74Salmonella infection_Homo sapiens_hsa051321.02675341
75Dilated cardiomyopathy_Homo sapiens_hsa054141.02587080
76NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02445218
77Gastric acid secretion_Homo sapiens_hsa049711.01680037
78Legionellosis_Homo sapiens_hsa051341.01052260
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00837121
80Cardiac muscle contraction_Homo sapiens_hsa042600.98942598
81Morphine addiction_Homo sapiens_hsa050320.96759752
82DNA replication_Homo sapiens_hsa030300.94449978
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.93517486
84GABAergic synapse_Homo sapiens_hsa047270.92920857
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92449225
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92081296
87Small cell lung cancer_Homo sapiens_hsa052220.91090997
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91040592
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89835146
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89264272
91Osteoclast differentiation_Homo sapiens_hsa043800.89112708
92Malaria_Homo sapiens_hsa051440.86494101
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85815392
94Influenza A_Homo sapiens_hsa051640.85760257
95Rheumatoid arthritis_Homo sapiens_hsa053230.85326723
96Nicotine addiction_Homo sapiens_hsa050330.85251080
97Bladder cancer_Homo sapiens_hsa052190.84256039
98Phagosome_Homo sapiens_hsa041450.84092871
99N-Glycan biosynthesis_Homo sapiens_hsa005100.83341337
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82247512
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81756027
102Melanogenesis_Homo sapiens_hsa049160.80921925
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79891326
104Base excision repair_Homo sapiens_hsa034100.78069111
105ErbB signaling pathway_Homo sapiens_hsa040120.77348659
106Biosynthesis of amino acids_Homo sapiens_hsa012300.76035596
107Gap junction_Homo sapiens_hsa045400.74957044
108FoxO signaling pathway_Homo sapiens_hsa040680.73772742
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72770461
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72156594
111MAPK signaling pathway_Homo sapiens_hsa040100.72123591
112Taste transduction_Homo sapiens_hsa047420.71378528
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.71060837
114Retinol metabolism_Homo sapiens_hsa008300.70537857
115Olfactory transduction_Homo sapiens_hsa047400.69704628
116Calcium signaling pathway_Homo sapiens_hsa040200.69628030
117Alzheimers disease_Homo sapiens_hsa050100.69558802
118Prolactin signaling pathway_Homo sapiens_hsa049170.69390435
119TNF signaling pathway_Homo sapiens_hsa046680.69296958
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68688846
121Graft-versus-host disease_Homo sapiens_hsa053320.68558903
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67672901
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66744837
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65556422
125Fatty acid degradation_Homo sapiens_hsa000710.64954269
126Autoimmune thyroid disease_Homo sapiens_hsa053200.63386615
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62954103
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59783085
129Focal adhesion_Homo sapiens_hsa045100.58954843
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58741042
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.57960657
132Endometrial cancer_Homo sapiens_hsa052130.57530228
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56800862
134Starch and sucrose metabolism_Homo sapiens_hsa005000.56754810
135Folate biosynthesis_Homo sapiens_hsa007900.56359244
136Carbon metabolism_Homo sapiens_hsa012000.55760748
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.55585010
138VEGF signaling pathway_Homo sapiens_hsa043700.55241053
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54604141
140Tyrosine metabolism_Homo sapiens_hsa003500.53680664
141Pyrimidine metabolism_Homo sapiens_hsa002400.53111757
142AMPK signaling pathway_Homo sapiens_hsa041520.52888559
143Oxidative phosphorylation_Homo sapiens_hsa001900.52241509
144Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51268277
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50672462
146Arginine biosynthesis_Homo sapiens_hsa002200.50167491
147Leishmaniasis_Homo sapiens_hsa051400.49494469
148Tuberculosis_Homo sapiens_hsa051520.49297243
149Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49093224
150Prion diseases_Homo sapiens_hsa050200.48943676
151Chronic myeloid leukemia_Homo sapiens_hsa052200.48717048
152B cell receptor signaling pathway_Homo sapiens_hsa046620.48704959
153cAMP signaling pathway_Homo sapiens_hsa040240.48514974
154Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47924616
155Sulfur relay system_Homo sapiens_hsa041220.47659267
156Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47613664
157Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47467322
158Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47226253
159Proteoglycans in cancer_Homo sapiens_hsa052050.46183257
160Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46032371
161Pancreatic cancer_Homo sapiens_hsa052120.45478839
162Peroxisome_Homo sapiens_hsa041460.45324067
163AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44792021
164Toxoplasmosis_Homo sapiens_hsa051450.43474426
165Antigen processing and presentation_Homo sapiens_hsa046120.43220058
166Parkinsons disease_Homo sapiens_hsa050120.42227512
167Nitrogen metabolism_Homo sapiens_hsa009100.41514479
168Thyroid cancer_Homo sapiens_hsa052160.41419755
169Renin-angiotensin system_Homo sapiens_hsa046140.39897760
170Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36582616
171Vitamin digestion and absorption_Homo sapiens_hsa049770.36331600
172Metabolic pathways_Homo sapiens_hsa011000.35426348
173Renal cell carcinoma_Homo sapiens_hsa052110.35381886

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