OPN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)7.26583948
2negative regulation of cardiac muscle cell apoptotic process (GO:0010667)7.20139391
3muscle filament sliding (GO:0030049)6.67352518
4actin-myosin filament sliding (GO:0033275)6.67352518
5cardiac myofibril assembly (GO:0055003)6.55527886
6sarcomere organization (GO:0045214)6.41781832
7cardiac muscle tissue morphogenesis (GO:0055008)6.31479232
8negative regulation of striated muscle cell apoptotic process (GO:0010664)6.04514365
9negative regulation of protein localization to cell surface (GO:2000009)6.04302237
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.91664348
11inositol phosphate dephosphorylation (GO:0046855)5.90901237
12phosphorylated carbohydrate dephosphorylation (GO:0046838)5.90901237
13myofibril assembly (GO:0030239)5.87374372
14membrane depolarization during action potential (GO:0086010)5.83651788
15actin-mediated cell contraction (GO:0070252)5.77569848
16ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.70360098
17regulation of sequestering of triglyceride (GO:0010889)5.68397227
18muscle tissue morphogenesis (GO:0060415)5.66424292
19calcium ion import (GO:0070509)5.64410509
20positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021105.47194042
21mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)5.47194042
22energy coupled proton transport, down electrochemical gradient (GO:0015985)5.46983453
23ATP synthesis coupled proton transport (GO:0015986)5.46983453
24inositol phosphate catabolic process (GO:0071545)5.46502155
25negative regulation of inclusion body assembly (GO:0090084)5.37962724
26negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.27488707
27axon ensheathment in central nervous system (GO:0032291)5.26403890
28central nervous system myelination (GO:0022010)5.26403890
29cardiac muscle contraction (GO:0060048)5.19799986
30tachykinin receptor signaling pathway (GO:0007217)5.12564259
31positive regulation of vascular permeability (GO:0043117)5.11136582
32heart contraction (GO:0060047)4.86167035
33heart process (GO:0003015)4.86167035
34reproduction (GO:0000003)4.83170561
35regulation of relaxation of muscle (GO:1901077)4.82801517
36response to pheromone (GO:0019236)4.78092611
37regulation of cardioblast differentiation (GO:0051890)4.66824526
38cardiac muscle cell development (GO:0055013)4.66633882
39platelet dense granule organization (GO:0060155)4.66420466
40regulation of vesicle fusion (GO:0031338)4.62436366
41proline transport (GO:0015824)4.61543121
42actomyosin structure organization (GO:0031032)4.55491740
43adult heart development (GO:0007512)4.53832932
44regulation of cardiac muscle cell apoptotic process (GO:0010665)4.51726867
45regulation of striated muscle cell apoptotic process (GO:0010662)4.51466152
46negative regulation of potassium ion transmembrane transport (GO:1901380)4.48343795
47negative regulation of skeletal muscle tissue development (GO:0048642)4.41471170
48cardiac cell development (GO:0055006)4.33794577
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.32352118
50cardiac muscle hypertrophy (GO:0003300)4.32269394
51respiratory electron transport chain (GO:0022904)4.28113786
52inositol metabolic process (GO:0006020)4.26047220
53response to misfolded protein (GO:0051788)4.19882205
54electron transport chain (GO:0022900)4.14800000
55actin filament-based movement (GO:0030048)4.14760809
56fatty acid elongation (GO:0030497)4.13705304
57regulation of gonadotropin secretion (GO:0032276)4.10562620
58striated muscle hypertrophy (GO:0014897)4.05160345
59positive regulation of mitochondrial membrane permeability (GO:0035794)4.00856300
60positive regulation of cardiac muscle cell differentiation (GO:2000727)3.99013494
61histone H3-K36 demethylation (GO:0070544)3.96092775
62negative regulation of cAMP-mediated signaling (GO:0043951)3.95609752
63regulation of actin filament-based movement (GO:1903115)3.91216120
64striated muscle contraction (GO:0006941)3.87842343
65negative regulation of myotube differentiation (GO:0010832)3.84963720
66heart trabecula formation (GO:0060347)3.83134898
67cullin deneddylation (GO:0010388)3.69899540
68positive regulation of uterine smooth muscle contraction (GO:0070474)3.69100417
69otic vesicle formation (GO:0030916)3.67783747
70vitamin transmembrane transport (GO:0035461)3.64399211
71positive regulation of cardiac muscle tissue development (GO:0055025)3.61809787
72regulation of transforming growth factor beta2 production (GO:0032909)3.61371928
73regulation of sarcomere organization (GO:0060297)3.58413044
74regulation of the force of heart contraction (GO:0002026)3.58180953
75muscle hypertrophy (GO:0014896)3.56860611
76oxidative phosphorylation (GO:0006119)3.53973661
77negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.51692970
78regulation of striated muscle contraction (GO:0006942)3.51035729
79membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50657187
80skeletal muscle contraction (GO:0003009)3.50586389
81sperm motility (GO:0030317)3.48865298
82regulation of cardiac muscle cell differentiation (GO:2000725)3.45665020
83bundle of His cell to Purkinje myocyte communication (GO:0086069)3.44358781
84response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.43712130
85regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.41941977
86neuronal action potential propagation (GO:0019227)3.36285940
87sarcoplasmic reticulum calcium ion transport (GO:0070296)3.34196040
88positive regulation of neurotransmitter secretion (GO:0001956)3.33764940
89ensheathment of neurons (GO:0007272)3.32379466
90axon ensheathment (GO:0008366)3.32379466
91tricarboxylic acid cycle (GO:0006099)3.30761939
92polyol catabolic process (GO:0046174)3.30563855
93myelination (GO:0042552)3.30024467
94alanine transport (GO:0032328)3.29970318
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.28955403
96ventricular cardiac muscle cell action potential (GO:0086005)3.28669235
97ATP biosynthetic process (GO:0006754)3.27220656
98negative regulation of exocytosis (GO:0045920)3.26615827
99positive regulation of actin filament depolymerization (GO:0030836)3.22741407
100regulation of cell communication by electrical coupling (GO:0010649)3.22683807
101regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.18545849
102regulation of skeletal muscle cell differentiation (GO:2001014)3.17032453
103regulation of smooth muscle cell differentiation (GO:0051150)3.16027014
104auditory behavior (GO:0031223)3.14233613
105wound healing, spreading of epidermal cells (GO:0035313)3.13494436
106cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.12760421
107protein deneddylation (GO:0000338)3.12582794
108regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.10828197
109neuronal ion channel clustering (GO:0045161)3.10703427
110myelin maintenance (GO:0043217)3.07559173
111regulation of rhodopsin mediated signaling pathway (GO:0022400)3.04741336
112regulation of uterine smooth muscle contraction (GO:0070472)3.04636547
113cAMP catabolic process (GO:0006198)3.03924037
114response to inactivity (GO:0014854)3.03580859
115negative regulation of T cell receptor signaling pathway (GO:0050860)3.01302140
116negative regulation of muscle cell apoptotic process (GO:0010656)3.00405488
117regulation of skeletal muscle contraction (GO:0014819)2.99080222
118positive regulation of membrane potential (GO:0045838)2.99055113
119transepithelial transport (GO:0070633)2.97337348
120endocardial cushion development (GO:0003197)2.93090470
121cellular component maintenance (GO:0043954)2.92969446
122creatine metabolic process (GO:0006600)2.92800473
123uterus development (GO:0060065)2.91385537
124regulation of myoblast differentiation (GO:0045661)2.91317241
125transcytosis (GO:0045056)2.90329477
126positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.90005395
127* rhodopsin mediated signaling pathway (GO:0016056)2.89963877
128regulation of synapse maturation (GO:0090128)2.89899254
129positive regulation of cardiac muscle cell proliferation (GO:0060045)2.89745099
130regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.89458198
131cardiolipin metabolic process (GO:0032048)2.83590747
132negative regulation of neurotransmitter secretion (GO:0046929)2.82912678
133regulation of ruffle assembly (GO:1900027)2.82697097
134phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.82080012
135cellular sodium ion homeostasis (GO:0006883)2.81986562
136response to epinephrine (GO:0071871)2.81093270
137regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.80916756
138negative regulation of neurotransmitter transport (GO:0051589)2.80796500
139regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.79831273
140phasic smooth muscle contraction (GO:0014821)2.79071024
141regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.78926196
142substantia nigra development (GO:0021762)2.78889632
143negative regulation of heart rate (GO:0010459)2.78773947
144positive regulation of cardiac muscle tissue growth (GO:0055023)2.78515970
145positive regulation of tolerance induction (GO:0002645)2.78403650
146ventricular cardiac muscle cell development (GO:0055015)2.78250494
147regulation of muscle contraction (GO:0006937)2.76555450
148imidazole-containing compound metabolic process (GO:0052803)2.76359590
149sodium ion homeostasis (GO:0055078)2.75751934
150response to mercury ion (GO:0046689)2.75718878
151regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.73928489
152protein neddylation (GO:0045116)2.72860373
153epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.72544828
154actin filament depolymerization (GO:0030042)2.70587035
155regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.70489944
156regulation of membrane repolarization (GO:0060306)2.70266590
157response to redox state (GO:0051775)2.69989621
158tooth mineralization (GO:0034505)2.69918471
159regulation of ATPase activity (GO:0043462)2.69316913
160regulation of ATP catabolic process (GO:1903289)2.69316913
161long-chain fatty acid biosynthetic process (GO:0042759)2.69284092
162muscle contraction (GO:0006936)2.68934016
163cell communication involved in cardiac conduction (GO:0086065)2.68863569
164cyclic nucleotide catabolic process (GO:0009214)2.68247913
165microtubule nucleation (GO:0007020)2.67447214
166protein targeting to Golgi (GO:0000042)2.66875859
167regulation of cardiac muscle tissue development (GO:0055024)2.66652076
168positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.66096768
169thyroid gland development (GO:0030878)2.65982014
170calcium ion transmembrane transport (GO:0070588)2.63341437
171behavioral response to nicotine (GO:0035095)2.60110000
172regulation of T cell tolerance induction (GO:0002664)2.58243261
173single fertilization (GO:0007338)2.58071972
174endosome organization (GO:0007032)2.57449262
175membrane depolarization (GO:0051899)2.57441478
176establishment of protein localization to Golgi (GO:0072600)2.57361883
177positive regulation of neurotransmitter transport (GO:0051590)2.56535533
178regulation of megakaryocyte differentiation (GO:0045652)2.55087311
179phosphatidylglycerol biosynthetic process (GO:0006655)2.53948809
180neuromuscular synaptic transmission (GO:0007274)2.52628289
181sperm capacitation (GO:0048240)10.6486587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EP300_21415370_ChIP-Seq_HL-1_Mouse3.41421225
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.91668515
3CDX2_19796622_ChIP-Seq_MESCs_Mouse2.79446473
4GBX2_23144817_ChIP-Seq_PC3_Human2.70341400
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62221225
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.58720556
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.45518601
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44838056
9AR_21572438_ChIP-Seq_LNCaP_Human2.43809828
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.38110319
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.37003309
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.33737749
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.24099478
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21810699
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21810699
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21450979
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.17771399
18EZH2_22144423_ChIP-Seq_EOC_Human2.13566637
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06498493
20SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.02043275
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96231160
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.90384645
23GATA1_22025678_ChIP-Seq_K562_Human1.89757347
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89321968
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78893462
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75305848
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.74534563
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74071125
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73846011
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73047536
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.64710361
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61278176
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61021624
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59583457
35ISL1_27105846_Chip-Seq_CPCs_Mouse1.54133616
36* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.52653761
37SPI1_20517297_ChIP-Seq_HL60_Human1.51853187
38REST_21632747_ChIP-Seq_MESCs_Mouse1.51529240
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50207736
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.49988293
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.47652645
42MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.46425882
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44902139
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42249145
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37728365
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.34507178
47TBX20_22328084_ChIP-Seq_HEART_Mouse1.34442610
48TBX20_22080862_ChIP-Seq_HEART_Mouse1.34442610
49TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.34306715
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33581635
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33437592
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32916608
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32880958
54SOX2_19829295_ChIP-Seq_ESCs_Human1.30972307
55NANOG_19829295_ChIP-Seq_ESCs_Human1.30972307
56OCT4_20526341_ChIP-Seq_ESCs_Human1.30915222
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30630915
58* SA1_27219007_Chip-Seq_Bcells_Human1.27478560
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.26395084
60EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.20268003
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.20003067
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18786982
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.15634368
64IGF1R_20145208_ChIP-Seq_DFB_Human1.15475157
65TCF4_18268006_ChIP-ChIP_LS174T_Human1.14872714
66TAF2_19829295_ChIP-Seq_ESCs_Human1.14784460
67ER_23166858_ChIP-Seq_MCF-7_Human1.14341910
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14313618
69DROSHA_22980978_ChIP-Seq_HELA_Human1.12635706
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12273032
71* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11567794
72VDR_22108803_ChIP-Seq_LS180_Human1.11159161
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.10759760
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10723966
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10430327
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09920287
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09850067
78P300_19829295_ChIP-Seq_ESCs_Human1.09061295
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08809289
80FOXA1_25329375_ChIP-Seq_VCAP_Human1.08796918
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08796918
82EOMES_21245162_ChIP-Seq_HESCs_Human1.08491700
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07859762
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.07419237
85AR_25329375_ChIP-Seq_VCAP_Human1.06912660
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06814085
87* AR_19668381_ChIP-Seq_PC3_Human1.06809761
88NANOG_20526341_ChIP-Seq_ESCs_Human1.05473203
89TAF15_26573619_Chip-Seq_HEK293_Human1.05364579
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05171247
91PU1_27457419_Chip-Seq_LIVER_Mouse1.04388030
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04318930
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.04274367
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.03820681
95EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03677607
96SMAD4_21741376_ChIP-Seq_HESCs_Human1.03626327
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03516730
98KDM2B_26808549_Chip-Seq_REH_Human1.03363743
99TP53_16413492_ChIP-PET_HCT116_Human1.02783507
100* CTCF_27219007_Chip-Seq_Bcells_Human1.02469223
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02439356
102AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02262886
103* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02214194
104P53_22387025_ChIP-Seq_ESCs_Mouse1.02028052
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.01732934
106* SMAD4_21799915_ChIP-Seq_A2780_Human1.01377787
107RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00286569
108OCT4_18555785_Chip-Seq_ESCs_Mouse0.99841018
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99331067
110ARNT_22903824_ChIP-Seq_MCF-7_Human0.98976055
111TBL1_22424771_ChIP-Seq_293T_Human0.98836434
112WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98285858
113ETV1_20927104_ChIP-Seq_GIST48_Human0.98231251
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98076755
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98062070
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97715928
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97511820
118BCAT_22108803_ChIP-Seq_LS180_Human0.97251719
119CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96561228
120MYC_19829295_ChIP-Seq_ESCs_Human0.96492898
121CBX2_27304074_Chip-Seq_ESCs_Mouse0.96323217
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95712514
123FUS_26573619_Chip-Seq_HEK293_Human0.95357008
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93630989
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93156237
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.93125826
127PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.93067465
128TCF4_23295773_ChIP-Seq_U87_Human0.93037959
129* AR_20517297_ChIP-Seq_VCAP_Human0.92866313
130SMAD_19615063_ChIP-ChIP_OVARY_Human0.92804008
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92731127
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92141167
133POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92105742
134ZNF274_21170338_ChIP-Seq_K562_Hela0.91820126
135ERA_21632823_ChIP-Seq_H3396_Human0.91805456
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91692322
137CBX2_22325352_ChIP-Seq_293T-Rex_Human0.90780239
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90581836
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90068993
140STAT3_23295773_ChIP-Seq_U87_Human0.89628137
141PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89256719
142PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88195467
143RING1B_27294783_Chip-Seq_ESCs_Mouse0.88038504
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86040777
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.85995544
146PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85917012
147HTT_18923047_ChIP-ChIP_STHdh_Human0.85617004
148E2F1_18555785_Chip-Seq_ESCs_Mouse0.85484789
149SOX2_21211035_ChIP-Seq_LN229_Gbm0.85243724
150GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85024726
151TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82238892
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82109718
153NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82109718
154FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81887540
155SOX2_18555785_Chip-Seq_ESCs_Mouse0.81640619

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation6.88070775
2MP0005083_abnormal_biliary_tract6.14596325
3MP0000749_muscle_degeneration4.32371447
4MP0004084_abnormal_cardiac_muscle4.19495933
5MP0003950_abnormal_plasma_membrane4.12580647
6MP0002837_dystrophic_cardiac_calcinosis3.56600397
7MP0004036_abnormal_muscle_relaxation3.52102511
8MP0005085_abnormal_gallbladder_physiolo3.13860720
9MP0000751_myopathy3.04937835
10MP0005451_abnormal_body_composition2.99269366
11MP0005330_cardiomyopathy2.98883623
12MP0004510_myositis2.95901970
13MP0002972_abnormal_cardiac_muscle2.94918902
14MP0005365_abnormal_bile_salt2.81032621
15MP0008775_abnormal_heart_ventricle2.80820558
16MP0004215_abnormal_myocardial_fiber2.74062146
17MP0004043_abnormal_pH_regulation2.68699670
18MP0005084_abnormal_gallbladder_morpholo2.65807671
19MP0004087_abnormal_muscle_fiber2.46943931
20MP0002822_catalepsy2.45414404
21MP0003137_abnormal_impulse_conducting2.45396694
22MP0004145_abnormal_muscle_electrophysio2.44984327
23MP0002735_abnormal_chemical_nociception2.32331383
24MP0000372_irregular_coat_pigmentation2.31840824
25MP0000920_abnormal_myelination2.28811244
26MP0005620_abnormal_muscle_contractility2.24447816
27MP0003221_abnormal_cardiomyocyte_apopto2.13243062
28MP0010630_abnormal_cardiac_muscle2.10081033
29MP0006138_congestive_heart_failure2.09198981
30MP0003646_muscle_fatigue2.06322919
31MP0000747_muscle_weakness2.02434490
32MP0004085_abnormal_heartbeat2.01942539
33MP0002106_abnormal_muscle_physiology1.86053481
34MP0001544_abnormal_cardiovascular_syste1.80574495
35MP0005385_cardiovascular_system_phenoty1.80574495
36MP0002736_abnormal_nociception_after1.78034258
37MP0002269_muscular_atrophy1.76700707
38MP0004147_increased_porphyrin_level1.75568318
39MP0003806_abnormal_nucleotide_metabolis1.73955032
40MP0003122_maternal_imprinting1.71650564
41MP0002928_abnormal_bile_duct1.71173281
42MP0004484_altered_response_of1.63145099
43MP0001529_abnormal_vocalization1.62846710
44MP0005379_endocrine/exocrine_gland_phen1.58466774
45MP0010386_abnormal_urinary_bladder1.57754025
46MP0004133_heterotaxia1.56135485
47MP0005369_muscle_phenotype1.53408626
48MP0003880_abnormal_central_pattern1.50735263
49MP0003191_abnormal_cellular_cholesterol1.47863094
50MP0001968_abnormal_touch/_nociception1.43880309
51MP0004270_analgesia1.43721593
52MP0005171_absent_coat_pigmentation1.43146009
53* MP0005253_abnormal_eye_physiology1.43098891
54MP0002127_abnormal_cardiovascular_syste1.41313153
55MP0003828_pulmonary_edema1.39321897
56MP0002734_abnormal_mechanical_nocicepti1.31885278
57MP0005623_abnormal_meninges_morphology1.28294486
58MP0002272_abnormal_nervous_system1.25189253
59MP0008874_decreased_physiological_sensi1.22406371
60MP0005666_abnormal_adipose_tissue1.22346364
61MP0009384_cardiac_valve_regurgitation1.20860382
62MP0002909_abnormal_adrenal_gland1.20154115
63MP0000759_abnormal_skeletal_muscle1.19159418
64MP0004859_abnormal_synaptic_plasticity1.19140570
65MP0004134_abnormal_chest_morphology1.17767546
66MP0005167_abnormal_blood-brain_barrier1.15784131
67* MP0002638_abnormal_pupillary_reflex1.14413515
68MP0004233_abnormal_muscle_weight1.14036697
69MP0006036_abnormal_mitochondrial_physio1.12245155
70MP0009046_muscle_twitch1.11886786
71MP0004142_abnormal_muscle_tone1.11427669
72MP0001486_abnormal_startle_reflex1.11368106
73MP0005645_abnormal_hypothalamus_physiol1.09286453
74MP0002572_abnormal_emotion/affect_behav1.09059030
75MP0002332_abnormal_exercise_endurance1.08755241
76MP0009780_abnormal_chondrocyte_physiolo1.04960272
77MP0001501_abnormal_sleep_pattern1.03395419
78MP0003690_abnormal_glial_cell1.01896360
79MP0001905_abnormal_dopamine_level0.98553344
80MP0001485_abnormal_pinna_reflex0.97589735
81MP0005551_abnormal_eye_electrophysiolog0.94840956
82MP0002064_seizures0.94480233
83MP0000343_altered_response_to0.92432958
84MP0000762_abnormal_tongue_morphology0.91730832
85MP0000778_abnormal_nervous_system0.90886135
86MP0004185_abnormal_adipocyte_glucose0.90309788
87MP0004019_abnormal_vitamin_homeostasis0.89927362
88MP0003329_amyloid_beta_deposits0.89587663
89MP0005266_abnormal_metabolism0.87025957
90MP0004742_abnormal_vestibular_system0.86415736
91MP0009745_abnormal_behavioral_response0.85632472
92MP0006072_abnormal_retinal_apoptosis0.83730173
93MP0003943_abnormal_hepatobiliary_system0.83451150
94MP0002229_neurodegeneration0.81840326
95MP0001661_extended_life_span0.80933709
96MP0006276_abnormal_autonomic_nervous0.80771813
97MP0000266_abnormal_heart_morphology0.79797565
98MP0005670_abnormal_white_adipose0.79190389
99MP0003567_abnormal_fetal_cardiomyocyte0.78091403
100MP0008569_lethality_at_weaning0.77373830
101MP0000230_abnormal_systemic_arterial0.76610589
102MP0004924_abnormal_behavior0.75946641
103MP0005386_behavior/neurological_phenoty0.75946641
104MP0000750_abnormal_muscle_regeneration0.75441139
105MP0003635_abnormal_synaptic_transmissio0.75329024
106MP0005423_abnormal_somatic_nervous0.74087300
107MP0001440_abnormal_grooming_behavior0.73027706
108MP0001970_abnormal_pain_threshold0.72611579
109MP0002234_abnormal_pharynx_morphology0.72122201
110MP0001986_abnormal_taste_sensitivity0.71459835
111MP0005408_hypopigmentation0.71135392
112MP0002733_abnormal_thermal_nociception0.70893466
113MP0004885_abnormal_endolymph0.70571205
114MP0003136_yellow_coat_color0.69501240
115MP0002108_abnormal_muscle_morphology0.67881701
116* MP0002752_abnormal_somatic_nervous0.66101472
117MP0003385_abnormal_body_wall0.65936695
118MP0006035_abnormal_mitochondrial_morpho0.65762878
119MP0002877_abnormal_melanocyte_morpholog0.65155024
120MP0002066_abnormal_motor_capabilities/c0.64198454
121MP0002102_abnormal_ear_morphology0.63667880
122MP0003634_abnormal_glial_cell0.63250389
123MP0003938_abnormal_ear_development0.62787276
124MP0005388_respiratory_system_phenotype0.62765184
125MP0002133_abnormal_respiratory_system0.62765184
126MP0002067_abnormal_sensory_capabilities0.61864279
127MP0002078_abnormal_glucose_homeostasis0.60429450
128MP0000538_abnormal_urinary_bladder0.59671256
129MP0002184_abnormal_innervation0.59396973
130MP0003283_abnormal_digestive_organ0.59272977
131MP0002063_abnormal_learning/memory/cond0.58827066
132MP0005595_abnormal_vascular_smooth0.58502973
133MP0002876_abnormal_thyroid_physiology0.58441100
134MP0004130_abnormal_muscle_cell0.58277844
135MP0003279_aneurysm0.57959988
136MP0003195_calcinosis0.56655780
137MP0002118_abnormal_lipid_homeostasis0.55688825
138* MP0002882_abnormal_neuron_morphology0.55018233
139MP0003879_abnormal_hair_cell0.54848106
140MP0006082_CNS_inflammation0.54013522

Predicted human phenotypes

RankGene SetZ-score
1Bilateral sensorineural hearing impairment (HP:0008619)7.19744036
2Exercise-induced muscle cramps (HP:0003710)5.74419419
3Muscle fiber inclusion bodies (HP:0100299)5.41151072
4Sudden death (HP:0001699)5.32436476
5Double outlet right ventricle (HP:0001719)4.99981338
6Congenital malformation of the right heart (HP:0011723)4.99981338
7Type 1 muscle fiber predominance (HP:0003803)4.92693670
8Exercise-induced myalgia (HP:0003738)4.84091272
9Calf muscle hypertrophy (HP:0008981)4.82336973
10Abnormality of dentin (HP:0010299)4.73842146
11Abnormality of glycolysis (HP:0004366)4.70879881
12Increased serum pyruvate (HP:0003542)4.70879881
13Pheochromocytoma (HP:0002666)4.68944832
14Ventricular tachycardia (HP:0004756)4.56887778
15Atrial fibrillation (HP:0005110)4.52319763
16Muscle hypertrophy of the lower extremities (HP:0008968)4.30530526
17Neuroendocrine neoplasm (HP:0100634)4.25061762
18Primary atrial arrhythmia (HP:0001692)4.22346748
19Hyporeflexia of lower limbs (HP:0002600)4.16386008
20Supraventricular tachycardia (HP:0004755)4.06817197
21Lipoatrophy (HP:0100578)3.95097698
22Supraventricular arrhythmia (HP:0005115)3.94891251
23Distal arthrogryposis (HP:0005684)3.90562292
24Abnormality of the calf musculature (HP:0001430)3.80453182
25Tetraplegia (HP:0002445)3.78544755
26Abnormality of the dental pulp (HP:0006479)3.75040266
27Myotonia (HP:0002486)3.71649848
28Muscle fiber splitting (HP:0003555)3.68513686
29Tinnitus (HP:0000360)3.65687917
30EMG: neuropathic changes (HP:0003445)3.60404302
31EMG: myopathic abnormalities (HP:0003458)3.36501642
32Right ventricular cardiomyopathy (HP:0011663)3.29408193
33Diaphragmatic weakness (HP:0009113)3.26384099
34Palpitations (HP:0001962)3.25701812
35Prolonged QT interval (HP:0001657)3.24868769
36Acute necrotizing encephalopathy (HP:0006965)3.23182454
37Azoospermia (HP:0000027)3.22921350
38Dilated cardiomyopathy (HP:0001644)3.22618329
39Spontaneous hematomas (HP:0007420)3.18653913
40Mitochondrial inheritance (HP:0001427)3.11453190
41Lower limb amyotrophy (HP:0007210)3.06818646
42Hepatocellular necrosis (HP:0001404)3.05101352
43Subaortic stenosis (HP:0001682)3.03835426
44Abnormality of the left ventricular outflow tract (HP:0011103)3.03835426
45Hepatic necrosis (HP:0002605)3.02997288
46Myoglobinuria (HP:0002913)3.02746884
47Round ear (HP:0100830)3.01761160
48Abnormal mitochondria in muscle tissue (HP:0008316)2.99452801
49Congenital stationary night blindness (HP:0007642)2.98892390
50Difficulty running (HP:0009046)2.98721131
51Acute encephalopathy (HP:0006846)2.96340763
52Syncope (HP:0001279)2.96190592
53Hand muscle atrophy (HP:0009130)2.95274388
54Upper limb amyotrophy (HP:0009129)2.92907496
55Distal upper limb amyotrophy (HP:0007149)2.92907496
56Hyperactive renin-angiotensin system (HP:0000841)2.84483314
57Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.80385028
58Degeneration of the lateral corticospinal tracts (HP:0002314)2.80385028
59Decreased circulating renin level (HP:0003351)2.79926755
60Increased CSF lactate (HP:0002490)2.79924353
61Rhabdomyolysis (HP:0003201)2.74854747
62Neck muscle weakness (HP:0000467)2.69250976
63Hyperkalemia (HP:0002153)2.67634960
64Focal motor seizures (HP:0011153)2.67392088
65Exercise intolerance (HP:0003546)2.66731675
66Broad face (HP:0000283)2.65655191
67Frequent falls (HP:0002359)2.65571816
68Steppage gait (HP:0003376)2.65429004
69Ventricular arrhythmia (HP:0004308)2.63903434
70Cerebral hemorrhage (HP:0001342)2.63478650
71Ragged-red muscle fibers (HP:0003200)2.61142961
72Prolonged neonatal jaundice (HP:0006579)2.59820255
73Sensory axonal neuropathy (HP:0003390)2.57019758
74Foot dorsiflexor weakness (HP:0009027)2.56702644
75Centrally nucleated skeletal muscle fibers (HP:0003687)2.53607073
76Abnormality of the foot musculature (HP:0001436)2.53488360
77Bundle branch block (HP:0011710)2.52491063
78Transposition of the great arteries (HP:0001669)2.52403575
79Abnormal connection of the cardiac segments (HP:0011545)2.52403575
80Abnormal ventriculo-arterial connection (HP:0011563)2.52403575
81Asymmetric septal hypertrophy (HP:0001670)2.50393919
82Increased hepatocellular lipid droplets (HP:0006565)2.50021508
83Progressive macrocephaly (HP:0004481)2.47354714
84Clonus (HP:0002169)2.46534392
85Truncus arteriosus (HP:0001660)2.46378545
86Myopathic facies (HP:0002058)2.45909455
87Abnormal EKG (HP:0003115)2.44837587
88Hypokalemic alkalosis (HP:0001949)2.42832959
89Abnormal spermatogenesis (HP:0008669)2.42809796
90Focal seizures (HP:0007359)2.42079018
91Mildly elevated creatine phosphokinase (HP:0008180)2.37020925
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35246251
93Deformed tarsal bones (HP:0008119)2.31974619
94Hypoplastic left heart (HP:0004383)2.30970735
95Leukodystrophy (HP:0002415)2.30532983
96Lipid accumulation in hepatocytes (HP:0006561)2.29954974
97Respiratory failure (HP:0002878)2.29500586
98Left ventricular hypertrophy (HP:0001712)2.26119642
99Ileus (HP:0002595)2.25045331
100Absent phalangeal crease (HP:0006109)2.23293360
101Conical tooth (HP:0000698)2.22901278
102Spastic tetraparesis (HP:0001285)2.21707782
103Nemaline bodies (HP:0003798)2.19105710
104Neoplasm of the peripheral nervous system (HP:0100007)2.18767954
105Achilles tendon contracture (HP:0001771)2.17536330
106Cholecystitis (HP:0001082)2.17047344
107Abnormal gallbladder physiology (HP:0012438)2.17047344
108Palmoplantar keratoderma (HP:0000982)2.16208405
109Myokymia (HP:0002411)2.15270117
110Abnormality of the corticospinal tract (HP:0002492)2.14932930
111Status epilepticus (HP:0002133)2.13973467
112Dry hair (HP:0011359)2.13077012
113Progressive external ophthalmoplegia (HP:0000590)2.12772571
114Ketoacidosis (HP:0001993)2.10800869
115Cerebral edema (HP:0002181)2.10333316
116Urinary bladder sphincter dysfunction (HP:0002839)2.09741946
117Childhood onset (HP:0011463)2.08443228
118Hypoplastic iliac wings (HP:0002866)2.07492173
119Heart block (HP:0012722)2.06161927
120Muscle stiffness (HP:0003552)2.04676633
121Neoplasm of the adrenal gland (HP:0100631)2.04277372
122Microvesicular hepatic steatosis (HP:0001414)2.04105715
123Amyotrophic lateral sclerosis (HP:0007354)2.03224078
124Abnormal pancreas size (HP:0012094)2.02831223
125Abnormal rod and cone electroretinograms (HP:0008323)2.02623283
126Ankle clonus (HP:0011448)2.01405292
127Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.00356449
128Ventricular fibrillation (HP:0001663)1.98526933
129Neurofibrillary tangles (HP:0002185)1.98123422
130Rimmed vacuoles (HP:0003805)1.96717864
131Increased serum lactate (HP:0002151)1.96362124
132Confusion (HP:0001289)1.95918987
133Prominent supraorbital ridges (HP:0000336)1.95694995
134Anhidrosis (HP:0000970)1.92025018
135Increased intramyocellular lipid droplets (HP:0012240)1.91776114
136Pancreatic islet-cell hyperplasia (HP:0004510)1.91637176
137Delayed CNS myelination (HP:0002188)1.90945230
138Parakeratosis (HP:0001036)1.90548658
139Abnormality of the Achilles tendon (HP:0005109)1.89364226
140Conjunctival hamartoma (HP:0100780)1.89325200
141Hypoplastic ischia (HP:0003175)1.89166402
142Hypokalemia (HP:0002900)1.88372006
143Abnormal atrioventricular conduction (HP:0005150)1.87956498
144Akinesia (HP:0002304)1.86293526
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86122209
146Generalized muscle weakness (HP:0003324)1.85799419
147Abnormality of the lower motor neuron (HP:0002366)1.85171845
148Distal lower limb muscle weakness (HP:0009053)1.83851438
149Lactic acidosis (HP:0003128)1.83781434
150Cerebral hypomyelination (HP:0006808)1.83570535
151Calcaneovalgus deformity (HP:0001848)1.82875287
152Intention tremor (HP:0002080)1.82558789
153Abnormal gallbladder morphology (HP:0012437)1.82310614
154Hepatoblastoma (HP:0002884)1.82272732
155Abnormal pupillary function (HP:0007686)1.81095353
156Areflexia of lower limbs (HP:0002522)1.80972569
157Bulbar palsy (HP:0001283)1.77798932
158Abnormal hair whorl (HP:0010721)1.77724270
159Constricted visual fields (HP:0001133)1.77036026
160Epidermoid cyst (HP:0200040)1.75305038
161Enlarged epiphyses (HP:0010580)1.75138192
162Abnormality of renin-angiotensin system (HP:0000847)1.74661793
163Rectal prolapse (HP:0002035)1.74418578
164Ulnar deviation of the wrist (HP:0003049)1.73174004
165Concave nail (HP:0001598)1.72708953
166Abnormality of skeletal muscle fiber size (HP:0012084)1.70531357
167Spastic gait (HP:0002064)1.70211581
168Broad-based gait (HP:0002136)1.69486951
169Renal salt wasting (HP:0000127)1.68927323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.06306038
2NME15.78709856
3STK395.64609108
4SIK35.53276505
5SIK14.33277294
6SIK23.63701864
7LIMK13.48859239
8MYLK3.44938985
9ZAK3.19776266
10WNK42.93795851
11RIPK12.87717049
12OXSR12.47098768
13PINK12.19627011
14PKN12.15168372
15CDC42BPA2.00604762
16WNK11.87722262
17BCR1.86688211
18MARK31.77746309
19CLK11.73842512
20TESK11.64603371
21NEK11.62956242
22MAP3K111.58013489
23CAMK2D1.55004649
24PHKG11.48735546
25PHKG21.48735546
26PIK3CA1.46251610
27ICK1.40061766
28MAP2K61.38807897
29VRK11.38048564
30PBK1.32708591
31PAK31.25976556
32NTRK11.24705083
33UHMK11.23811463
34LMTK21.22674997
35CAMKK11.22518124
36ARAF1.22515810
37DAPK21.21763635
38TTN1.18479954
39ROCK21.14215827
40JAK31.11136576
41PRKG21.10568193
42PRKD31.04271820
43MET1.04132446
44PRKAA11.03746557
45TRPM71.03196949
46KIT1.02810359
47ILK1.02534508
48MST41.01790571
49FGR0.98327961
50CAMK2A0.97769886
51SGK4940.96905481
52SGK2230.96905481
53MAPK130.96657403
54NLK0.95734736
55MUSK0.94907115
56TSSK60.94367783
57TXK0.93680766
58CAMK2G0.93640516
59CASK0.92975965
60CAMK2B0.92941387
61MARK20.90790583
62GRK10.89533380
63MAP3K90.89454539
64IRAK10.88645836
65CSNK1G30.85235384
66PLK20.85001552
67ERBB40.84523324
68FRK0.84072771
69MAPKAPK50.84025127
70STK240.83983750
71PASK0.83473784
72EPHB10.82671107
73NEK90.82461476
74PRPF4B0.78926382
75PRKD10.78706829
76CSNK1A1L0.75560025
77BCKDK0.74955159
78DAPK30.74872508
79PRKCE0.74075277
80PRKCQ0.73428298
81MELK0.72822036
82ITK0.70765704
83DMPK0.70366838
84IRAK30.69323698
85MAP3K70.68825706
86TEC0.68191797
87EPHA40.67608116
88PRKCH0.65872598
89CAMK10.65149221
90MAPKAPK30.64828830
91MAP3K130.63882648
92PRKCG0.63239594
93PRKG10.63074814
94NTRK30.62106356
95MINK10.61427581
96NEK60.59471073
97CSNK1G10.58805594
98TNK20.58541153
99PRKACB0.58319892
100NTRK20.57852191
101DYRK20.57622615
102CDK140.57214930
103MAPK150.57089585
104STK160.56568868
105ROCK10.55538461
106CDK80.55226444
107BMPR20.51415123
108TYRO30.50749628
109ERBB30.50737255
110MAPK120.48049079
111* PRKACA0.48026068
112PTK2B0.47925636
113KSR20.47495258
114MARK10.47000504
115CDK180.46411445
116CDK150.45662964
117KSR10.44830319
118CAMK40.44814705
119GRK70.44176071
120TESK20.41871989
121IRAK20.41566321
122AKT30.41454802
123PDK40.41199517
124PDK30.41199517
125FYN0.40178342
126ADRBK20.39146438
127CDK190.39130195
128PRKAA20.39109258
129PAK60.38056375
130STK110.37626810
131JAK10.37509169
132BTK0.37007053
133EPHB20.36976385
134STK40.36396035
135CDK11A0.35731974
136SGK10.35206932
137CSNK1G20.35183554
138LATS20.34070407
139AKT20.33666183
140CDK50.33339414
141RPS6KB10.33144168
142CSNK1A10.33029915
143PDPK10.32911421
144PIK3CG0.32809293
145TGFBR20.31900667
146DDR20.31745609
147PRKCB0.30839094
148RAF10.30651524
149IKBKE0.30032686
150FES0.29334558
151TIE10.29294599
152ABL20.28551870
153TAOK30.28276509
154TNIK0.28133931
155CSNK1D0.27461349
156LCK0.26299919
157PLK30.25760447
158GRK50.24374013
159PRKACG0.23601579
160PIM20.21990267

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042604.66030588
2Oxidative phosphorylation_Homo sapiens_hsa001904.43874764
3Parkinsons disease_Homo sapiens_hsa050124.11347915
4Fatty acid elongation_Homo sapiens_hsa000623.29043387
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.27759980
6Alzheimers disease_Homo sapiens_hsa050103.02501536
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.83726830
8Dilated cardiomyopathy_Homo sapiens_hsa054142.78782402
9Huntingtons disease_Homo sapiens_hsa050162.73788393
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.56303610
11One carbon pool by folate_Homo sapiens_hsa006702.45870214
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.32280158
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.05020150
14Selenocompound metabolism_Homo sapiens_hsa004501.99950500
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.97373560
16Retinol metabolism_Homo sapiens_hsa008301.97168080
17Propanoate metabolism_Homo sapiens_hsa006401.95449348
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89044998
19Insulin secretion_Homo sapiens_hsa049111.80171169
20Steroid biosynthesis_Homo sapiens_hsa001001.74439129
21Carbon metabolism_Homo sapiens_hsa012001.72813132
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72067720
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68868137
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64090208
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61719973
26Pyruvate metabolism_Homo sapiens_hsa006201.59682056
27Gastric acid secretion_Homo sapiens_hsa049711.52370907
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49530354
29Taste transduction_Homo sapiens_hsa047421.49426767
30Tight junction_Homo sapiens_hsa045301.48183639
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46292787
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38284203
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37035942
34Fatty acid metabolism_Homo sapiens_hsa012121.33689878
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33660090
36Butanoate metabolism_Homo sapiens_hsa006501.33158548
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.30824993
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29293032
39Regulation of autophagy_Homo sapiens_hsa041401.25710654
40ABC transporters_Homo sapiens_hsa020101.25147057
41Bile secretion_Homo sapiens_hsa049761.15671260
42Ether lipid metabolism_Homo sapiens_hsa005651.14051246
43Fatty acid degradation_Homo sapiens_hsa000711.11780042
44Biosynthesis of amino acids_Homo sapiens_hsa012301.11573102
45Histidine metabolism_Homo sapiens_hsa003401.10169037
46Fatty acid biosynthesis_Homo sapiens_hsa000611.08678953
47Nitrogen metabolism_Homo sapiens_hsa009101.07802012
48Phototransduction_Homo sapiens_hsa047441.06639757
49Caffeine metabolism_Homo sapiens_hsa002321.05182068
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04449561
51Inositol phosphate metabolism_Homo sapiens_hsa005621.00843187
52Circadian entrainment_Homo sapiens_hsa047130.97569706
53Dorso-ventral axis formation_Homo sapiens_hsa043200.97307817
54Axon guidance_Homo sapiens_hsa043600.96218875
55Cocaine addiction_Homo sapiens_hsa050300.96021881
56Pancreatic secretion_Homo sapiens_hsa049720.95335418
57Fat digestion and absorption_Homo sapiens_hsa049750.95319440
58Glycerolipid metabolism_Homo sapiens_hsa005610.93155693
59Tryptophan metabolism_Homo sapiens_hsa003800.93113546
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91443187
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90777920
62Serotonergic synapse_Homo sapiens_hsa047260.90178760
63Basal transcription factors_Homo sapiens_hsa030220.90172107
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88262080
65Tyrosine metabolism_Homo sapiens_hsa003500.81434280
66GABAergic synapse_Homo sapiens_hsa047270.79826387
67Glutamatergic synapse_Homo sapiens_hsa047240.79384699
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.78928929
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78428965
70Hedgehog signaling pathway_Homo sapiens_hsa043400.78311785
71Malaria_Homo sapiens_hsa051440.78299006
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73725822
73Morphine addiction_Homo sapiens_hsa050320.71894248
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.71103249
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.70209050
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.70102155
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70098845
78Olfactory transduction_Homo sapiens_hsa047400.69968528
79Thyroid hormone synthesis_Homo sapiens_hsa049180.68473824
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68010575
81Calcium signaling pathway_Homo sapiens_hsa040200.66917054
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66002603
83Basal cell carcinoma_Homo sapiens_hsa052170.65875651
84Insulin resistance_Homo sapiens_hsa049310.64572053
85Arginine and proline metabolism_Homo sapiens_hsa003300.64106820
86Nicotine addiction_Homo sapiens_hsa050330.63151506
87Metabolic pathways_Homo sapiens_hsa011000.61666074
88Peroxisome_Homo sapiens_hsa041460.59770890
89Long-term depression_Homo sapiens_hsa047300.58676870
90Phenylalanine metabolism_Homo sapiens_hsa003600.55517758
91Sulfur metabolism_Homo sapiens_hsa009200.55123980
92Circadian rhythm_Homo sapiens_hsa047100.54393210
93Linoleic acid metabolism_Homo sapiens_hsa005910.54211714
94Synaptic vesicle cycle_Homo sapiens_hsa047210.53352111
95Sphingolipid metabolism_Homo sapiens_hsa006000.52332807
96Melanogenesis_Homo sapiens_hsa049160.52008073
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51553539
98Oxytocin signaling pathway_Homo sapiens_hsa049210.49765954
99Hippo signaling pathway_Homo sapiens_hsa043900.49502220
100Dopaminergic synapse_Homo sapiens_hsa047280.47616815
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47415307
102Collecting duct acid secretion_Homo sapiens_hsa049660.47125123
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46134966
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44720279
105Insulin signaling pathway_Homo sapiens_hsa049100.43031000
106PPAR signaling pathway_Homo sapiens_hsa033200.42519752
107Arginine biosynthesis_Homo sapiens_hsa002200.40633919
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39264553
109Vibrio cholerae infection_Homo sapiens_hsa051100.39229725
110beta-Alanine metabolism_Homo sapiens_hsa004100.38322990
111Estrogen signaling pathway_Homo sapiens_hsa049150.37711768
112Prion diseases_Homo sapiens_hsa050200.37669766
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37422337
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37363454
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36924195
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36862399
117Cholinergic synapse_Homo sapiens_hsa047250.36312096
118RNA polymerase_Homo sapiens_hsa030200.36028660
119Protein digestion and absorption_Homo sapiens_hsa049740.35815477
120Salivary secretion_Homo sapiens_hsa049700.35571143
121T cell receptor signaling pathway_Homo sapiens_hsa046600.35398815
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35231144
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33524597
124Vitamin B6 metabolism_Homo sapiens_hsa007500.33158828
125Chemical carcinogenesis_Homo sapiens_hsa052040.32386644
126Mineral absorption_Homo sapiens_hsa049780.31913266
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31404780
128cAMP signaling pathway_Homo sapiens_hsa040240.31392396
129Long-term potentiation_Homo sapiens_hsa047200.31329043
130Galactose metabolism_Homo sapiens_hsa000520.31266821
131ECM-receptor interaction_Homo sapiens_hsa045120.29948238
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29944111
133Vitamin digestion and absorption_Homo sapiens_hsa049770.28642103
134Renin secretion_Homo sapiens_hsa049240.28459615
135Folate biosynthesis_Homo sapiens_hsa007900.28340252
136Endocytosis_Homo sapiens_hsa041440.28271529
137Chemokine signaling pathway_Homo sapiens_hsa040620.27530499
138Ras signaling pathway_Homo sapiens_hsa040140.26922114
139Glucagon signaling pathway_Homo sapiens_hsa049220.26500333
140Ovarian steroidogenesis_Homo sapiens_hsa049130.26196300
141Arachidonic acid metabolism_Homo sapiens_hsa005900.24369259
142TGF-beta signaling pathway_Homo sapiens_hsa043500.23932424
143Autoimmune thyroid disease_Homo sapiens_hsa053200.23474376
144Asthma_Homo sapiens_hsa053100.22185104
145Amphetamine addiction_Homo sapiens_hsa050310.21747275
146Starch and sucrose metabolism_Homo sapiens_hsa005000.21369013
147Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.18564361
148Wnt signaling pathway_Homo sapiens_hsa043100.18563886
149Fructose and mannose metabolism_Homo sapiens_hsa000510.17512650
150Leukocyte transendothelial migration_Homo sapiens_hsa046700.16798508
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.15812628

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