OPN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA methylation involved in gamete generation (GO:0043046)8.38137472
2regulation of odontogenesis of dentin-containing tooth (GO:0042487)8.01728888
3lipopolysaccharide biosynthetic process (GO:0009103)7.69058255
4negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)7.36338592
5regulation of meiosis I (GO:0060631)7.08439841
6sulfate transmembrane transport (GO:1902358)6.70194796
7lipopolysaccharide metabolic process (GO:0008653)6.64189909
8regulation of pigment cell differentiation (GO:0050932)6.64176838
9positive regulation of developmental pigmentation (GO:0048087)6.56160686
10negative regulation of cell cycle G2/M phase transition (GO:1902750)6.39028497
11cellular glucuronidation (GO:0052695)6.35939042
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.33745820
13L-phenylalanine catabolic process (GO:0006559)6.33745820
14regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)6.22309530
15interleukin-6-mediated signaling pathway (GO:0070102)6.20497292
16regulation of protein glycosylation (GO:0060049)6.10265628
17piRNA metabolic process (GO:0034587)6.10011966
18negative regulation of JUN kinase activity (GO:0043508)6.03050231
19negative regulation of glycoprotein biosynthetic process (GO:0010561)5.89742072
20paraxial mesoderm development (GO:0048339)5.87668459
21CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.86719981
22glucuronate metabolic process (GO:0019585)5.76628939
23uronic acid metabolic process (GO:0006063)5.76628939
24tyrosine metabolic process (GO:0006570)5.74336030
25sulfate transport (GO:0008272)5.72044948
26centriole replication (GO:0007099)5.54577881
27L-phenylalanine metabolic process (GO:0006558)5.50341213
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.50341213
29regulation of type B pancreatic cell apoptotic process (GO:2000674)5.44938138
30notochord development (GO:0030903)5.26909621
31negative regulation of chemokine production (GO:0032682)5.23329806
32regulation of apoptotic process involved in morphogenesis (GO:1902337)5.23133490
33GTP biosynthetic process (GO:0006183)5.22453344
34CTP metabolic process (GO:0046036)5.08325696
35CTP biosynthetic process (GO:0006241)5.08325696
36regulation of interleukin-5 production (GO:0032674)4.98278943
37heme transport (GO:0015886)4.92062319
38branching involved in salivary gland morphogenesis (GO:0060445)4.85368963
39ribosomal small subunit assembly (GO:0000028)4.75107648
40regulation of transmission of nerve impulse (GO:0051969)4.71159179
41drinking behavior (GO:0042756)4.70273290
42monocyte chemotaxis (GO:0002548)4.67624070
43pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)4.63181822
44response to nitrosative stress (GO:0051409)4.60146824
45UTP biosynthetic process (GO:0006228)4.59609185
46aromatic amino acid family catabolic process (GO:0009074)4.57616079
47positive regulation of neurological system process (GO:0031646)4.57213083
48response to peptidoglycan (GO:0032494)4.56235102
49negative regulation of glycoprotein metabolic process (GO:1903019)4.51530661
50T cell lineage commitment (GO:0002360)4.46750692
51SMAD protein complex assembly (GO:0007183)4.46515498
52response to interferon-beta (GO:0035456)4.36310425
53gamma-aminobutyric acid signaling pathway (GO:0007214)4.35624990
54thrombin receptor signaling pathway (GO:0070493)4.34714977
55guanosine-containing compound biosynthetic process (GO:1901070)4.31732682
56regulation of T-helper 2 cell differentiation (GO:0045628)4.28926178
57pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)4.25152001
58nucleotide transmembrane transport (GO:1901679)4.22052720
59positive regulation of meiosis (GO:0045836)4.11918006
60UTP metabolic process (GO:0046051)4.09200476
61neutrophil mediated immunity (GO:0002446)4.04509107
62negative regulation of gluconeogenesis (GO:0045721)4.02860597
63glycerol metabolic process (GO:0006071)4.01586637
64negative regulation of stem cell proliferation (GO:2000647)3.98913046
65hematopoietic stem cell proliferation (GO:0071425)3.95822142
66centriole assembly (GO:0098534)3.94015871
67ribonucleoprotein complex disassembly (GO:0032988)3.93129364
68myotube differentiation (GO:0014902)3.92549688
69pyrimidine-containing compound transmembrane transport (GO:0072531)3.92229191
70tachykinin receptor signaling pathway (GO:0007217)3.89893242
71meiotic chromosome segregation (GO:0045132)3.89525318
72flavonoid metabolic process (GO:0009812)3.88319985
73nephron tubule formation (GO:0072079)3.85762389
74negative regulation of lipid storage (GO:0010888)3.84196015
75aromatic amino acid family metabolic process (GO:0009072)3.83658550
76bone remodeling (GO:0046849)3.83282449
77positive regulation of meiotic cell cycle (GO:0051446)3.81022936
78regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.80999667
79regulation of transforming growth factor beta2 production (GO:0032909)3.80824934
80response to mercury ion (GO:0046689)3.77238111
81natural killer cell activation involved in immune response (GO:0002323)3.76467452
82left/right axis specification (GO:0070986)3.76456424
83regulation of rhodopsin mediated signaling pathway (GO:0022400)3.75184286
84nodal signaling pathway (GO:0038092)3.74514226
85positive regulation of type 2 immune response (GO:0002830)3.73729160
86serotonin receptor signaling pathway (GO:0007210)3.66216408
87vitamin transmembrane transport (GO:0035461)3.64978035
88positive regulation of respiratory burst (GO:0060267)3.64094725
89negative regulation of JNK cascade (GO:0046329)3.63415280
90pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.63372905
91alditol metabolic process (GO:0019400)3.59700042
92regulation of chemokine biosynthetic process (GO:0045073)3.54539518
93pantothenate metabolic process (GO:0015939)3.53507994
94NAD biosynthetic process (GO:0009435)3.50884950
95iron coordination entity transport (GO:1901678)3.45572406
96rhodopsin mediated signaling pathway (GO:0016056)3.45203740
97viral mRNA export from host cell nucleus (GO:0046784)3.44269089
98negative regulation of neural precursor cell proliferation (GO:2000178)3.42125427
99iron ion import (GO:0097286)3.42034301
100regulation of odontogenesis (GO:0042481)3.39718238
101response to epinephrine (GO:0071871)3.39670216
102cellular response to gamma radiation (GO:0071480)3.39261839
103positive regulation of protein import into nucleus, translocation (GO:0033160)3.37890086
104sulfur compound transport (GO:0072348)3.37302575
105spermatid development (GO:0007286)3.36597250
106response to caffeine (GO:0031000)3.36283960
107neuron maturation (GO:0042551)3.35190403
108regulation of developmental pigmentation (GO:0048070)3.32287505
109dopamine biosynthetic process (GO:0042416)3.32172104
110DNA damage induced protein phosphorylation (GO:0006975)3.29178594
111germinal center formation (GO:0002467)3.27910057
112somite rostral/caudal axis specification (GO:0032525)3.27625219
113indolalkylamine metabolic process (GO:0006586)3.27479676
114negative regulation of epidermal cell differentiation (GO:0045605)3.26686763
115aspartate family amino acid catabolic process (GO:0009068)3.25689589
116regulation of cell fate specification (GO:0042659)3.23755720
117nephron tubule development (GO:0072080)3.23385077
118nephron epithelium development (GO:0072009)3.23314536
119regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.22634759
120heart valve formation (GO:0003188)3.21985038
121pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.17894557
122regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.17229597
123positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.17229597
124negative regulation of stress-activated MAPK cascade (GO:0032873)3.16100631
125negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)3.16100631
126regulation of triglyceride catabolic process (GO:0010896)3.14857915
127response to insecticide (GO:0017085)3.14713825
128sperm motility (GO:0030317)3.14126260
129cell wall macromolecule catabolic process (GO:0016998)3.13335582
130cell wall macromolecule metabolic process (GO:0044036)3.13335582
131protein retention in ER lumen (GO:0006621)3.12040975
132urate metabolic process (GO:0046415)3.07342429
133phospholipid scrambling (GO:0017121)3.07185131
134epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.06611165
135positive regulation of action potential (GO:0045760)3.04683945
136phosphate ion transmembrane transport (GO:0035435)3.02824910
137cellular response to interferon-beta (GO:0035458)3.01679241
138positive regulation of fatty acid oxidation (GO:0046321)3.01260335
139tryptophan catabolic process (GO:0006569)3.01056309
140indole-containing compound catabolic process (GO:0042436)3.01056309
141indolalkylamine catabolic process (GO:0046218)3.01056309
142myeloid leukocyte mediated immunity (GO:0002444)3.00893761
143post-anal tail morphogenesis (GO:0036342)3.00047730
144mitochondrial fission (GO:0000266)2.98802404
145sympathetic nervous system development (GO:0048485)2.97998987
146toxin transport (GO:1901998)2.96122188
147fusion of sperm to egg plasma membrane (GO:0007342)2.96109320
148regulation of synapse structural plasticity (GO:0051823)2.95753360
149regulation of immunoglobulin secretion (GO:0051023)2.92578374
150positive regulation of SMAD protein import into nucleus (GO:0060391)2.92330420
151positive regulation of digestive system process (GO:0060456)2.91214095
152regulation of DNA damage checkpoint (GO:2000001)2.90839424
153pseudouridine synthesis (GO:0001522)2.90614595
154regulation of circadian sleep/wake cycle (GO:0042749)2.89815018
155regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.89815018
156toxin metabolic process (GO:0009404)2.89303044
157regulation of synapse maturation (GO:0090128)2.88887706
158pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.87573555
159negative regulation of epidermis development (GO:0045683)2.86957841
160dopaminergic neuron differentiation (GO:0071542)2.86647368
161lysine metabolic process (GO:0006553)2.86291362
162lysine catabolic process (GO:0006554)2.86291362
163inflammatory response to antigenic stimulus (GO:0002437)2.84447021
164pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.84296501
165organelle disassembly (GO:1903008)2.82812454
166phosphatidylethanolamine metabolic process (GO:0046337)2.82287244
167maturation of SSU-rRNA (GO:0030490)2.82003237
168regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.81352024
169regulation of phospholipase A2 activity (GO:0032429)2.80806308
170regulation of sister chromatid cohesion (GO:0007063)2.80025524
171negative regulation of cell-matrix adhesion (GO:0001953)2.79944401
172negative regulation of metanephros development (GO:0072217)2.78772237
173defense response to protozoan (GO:0042832)2.77324003
174regulation of keratinocyte proliferation (GO:0010837)2.75691842
175renal tubule development (GO:0061326)2.75209907
176positive regulation of toll-like receptor signaling pathway (GO:0034123)2.75095139
177regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.75081497
178regulation of nuclear cell cycle DNA replication (GO:0033262)2.74109944
179drug transmembrane transport (GO:0006855)2.74027087
180cellular ketone body metabolic process (GO:0046950)2.72665093
181biotin metabolic process (GO:0006768)2.72201675
182neuron fate determination (GO:0048664)2.71325848
183aldehyde catabolic process (GO:0046185)2.70606036
184positive regulation of T-helper cell differentiation (GO:0045624)2.69802511
185regulation of pseudopodium assembly (GO:0031272)2.69539700
186acrosome reaction (GO:0007340)2.68853394
187organ induction (GO:0001759)2.68632831
188histamine transport (GO:0051608)2.68586544
189embryonic retina morphogenesis in camera-type eye (GO:0060059)2.67400663
190uterus development (GO:0060065)2.65746341
191maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.64999948
192detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.64964424
193kynurenine metabolic process (GO:0070189)2.59329308
194DNA alkylation (GO:0006305)2.58985364
195sphingosine metabolic process (GO:0006670)14.9782772
196diol metabolic process (GO:0034311)13.5641072
197sphingoid metabolic process (GO:0046519)12.6442010
198DNA damage response, detection of DNA damage (GO:0042769)12.4403619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.75635941
2IGF1R_20145208_ChIP-Seq_DFB_Human4.57118370
3AR_21572438_ChIP-Seq_LNCaP_Human4.55950301
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.18002851
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.95621132
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.94281162
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.87694545
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.84287796
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.80895969
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.51371533
11ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.42500191
12DROSHA_22980978_ChIP-Seq_HELA_Human2.36946044
13VDR_22108803_ChIP-Seq_LS180_Human2.35940350
14TP53_18474530_ChIP-ChIP_U2OS_Human2.22450088
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13251640
16ER_23166858_ChIP-Seq_MCF-7_Human2.05846261
17BP1_19119308_ChIP-ChIP_Hs578T_Human11.7441130
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.99545185
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98225704
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93995482
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91476509
22ZNF274_21170338_ChIP-Seq_K562_Hela1.90806550
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90451806
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90451806
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82676557
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.80862441
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77741968
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76918249
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76832580
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.76300201
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70148737
32STAT3_23295773_ChIP-Seq_U87_Human1.66358915
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65979615
34GATA1_22025678_ChIP-Seq_K562_Human1.65745592
35AR_25329375_ChIP-Seq_VCAP_Human1.65141146
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.64927675
37HOXB7_26014856_ChIP-Seq_BT474_Human1.61973815
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61293586
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61281556
40TCF4_23295773_ChIP-Seq_U87_Human1.61213389
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60595667
42BCAT_22108803_ChIP-Seq_LS180_Human1.58663035
43* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56199739
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.56194979
45OCT4_20526341_ChIP-Seq_ESCs_Human1.54716979
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53324477
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.46879002
48TAF15_26573619_Chip-Seq_HEK293_Human1.46739872
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.41650063
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41570357
51FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39618023
52* SMAD4_21741376_ChIP-Seq_EPCs_Human1.38631784
53SMAD4_21799915_ChIP-Seq_A2780_Human1.38498951
54* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38106077
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37704808
56CBP_20019798_ChIP-Seq_JUKART_Human1.37704808
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37580874
58RNF2_27304074_Chip-Seq_NSC_Mouse1.36403583
59STAT1_20625510_ChIP-Seq_HELA_Human1.34861862
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34809493
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34373137
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32626467
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30129502
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30129502
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30096740
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.28758212
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28758212
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27192445
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25319548
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25092580
71* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24142262
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23969330
73SMAD3_21741376_ChIP-Seq_ESCs_Human1.23161327
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23062366
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.22436237
76OCT1_27270436_Chip-Seq_PROSTATE_Human1.21804733
77TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21618484
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.21081238
79CEBPB_22108803_ChIP-Seq_LS180_Human1.20480279
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19681588
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19564381
82E2F7_22180533_ChIP-Seq_HELA_Human1.19485128
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.19451541
84MYC_19829295_ChIP-Seq_ESCs_Human1.18612397
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.17798254
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.17099159
87* NCOR_22424771_ChIP-Seq_293T_Human1.16211717
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15760829
89ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15279953
90EGR1_19032775_ChIP-ChIP_M12_Human1.15167002
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.14728906
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14616432
93NANOG_20526341_ChIP-Seq_ESCs_Human1.14091201
94FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14015138
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13804500
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13660311
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13120877
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.12750924
99* FOXH1_21741376_ChIP-Seq_ESCs_Human1.12307143
100* TCF4_22108803_ChIP-Seq_LS180_Human1.11814127
101VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10790538
102SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10542452
103EED_16625203_ChIP-ChIP_MESCs_Mouse1.10406705
104* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10347624
105* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09032425
106* CDX2_22108803_ChIP-Seq_LS180_Human1.08433130
107* AR_19668381_ChIP-Seq_PC3_Human1.08169834
108* STAT3_18555785_ChIP-Seq_MESCs_Mouse1.07864655
109ERG_21242973_ChIP-ChIP_JURKAT_Human1.07349300
110RAC3_21632823_ChIP-Seq_H3396_Human1.07152754
111IRF8_21731497_ChIP-ChIP_J774_Mouse1.06818964
112GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.06389647
113SOX2_20726797_ChIP-Seq_SW620_Human1.05295549
114CBP_21632823_ChIP-Seq_H3396_Human1.05169713
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.05043095
116SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04501128
117VDR_24787735_ChIP-Seq_THP-1_Human1.02970651
118SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02948792
119TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00575588
120P53_21459846_ChIP-Seq_SAOS-2_Human1.00346488
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00085446
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.00075089
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00073986
124TAF2_19829295_ChIP-Seq_ESCs_Human0.99950356
125TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99607356
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99560529
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99208304
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99117820
129REST_21632747_ChIP-Seq_MESCs_Mouse0.98561434
130* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98361631
131* SMAD3_21741376_ChIP-Seq_EPCs_Human0.95962968
132E2F1_18555785_Chip-Seq_ESCs_Mouse0.95085951
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.94791511
134TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94572165
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94183002
136GBX2_23144817_ChIP-Seq_PC3_Human0.93527900
137STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93250513
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93073673
139GATA3_21878914_ChIP-Seq_MCF-7_Human0.92330143
140E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90662331
141ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90633455
142KLF5_25053715_ChIP-Seq_YYC3_Human0.86599409
143* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86517297
144GATA4_25053715_ChIP-Seq_YYC3_Human0.85337955
145FUS_26573619_Chip-Seq_HEK293_Human0.84947075
146CJUN_26792858_Chip-Seq_BT549_Human0.83741798
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82939099
148CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82235510
149ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81625385
150SOX2_19829295_ChIP-Seq_ESCs_Human0.81511735
151NANOG_19829295_ChIP-Seq_ESCs_Human0.81511735
152SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81231761
153SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81231761
154P300_19829295_ChIP-Seq_ESCs_Human0.81136496
155SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80615339
156PCGF2_27294783_Chip-Seq_NPCs_Mouse0.80488051
157SOX2_16153702_ChIP-ChIP_HESCs_Human0.79531392
158ELK4_26923725_Chip-Seq_MESODERM_Mouse0.78616520
159RNF2_27304074_Chip-Seq_ESCs_Mouse0.78563543
160CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78505524
161P300_18555785_Chip-Seq_ESCs_Mouse0.77023538
162* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.75051205
163NR3C1_23031785_ChIP-Seq_PC12_Mouse0.74779419
164RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.74730269
165POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74023664
166PIAS1_25552417_ChIP-Seq_VCAP_Human0.73486575
167PRDM14_20953172_ChIP-Seq_ESCs_Human0.73242373
168CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.72081707
169EWS_26573619_Chip-Seq_HEK293_Human0.71608015
170GATA3_24758297_ChIP-Seq_MCF-7_Human0.71087356
171RING1B_27294783_Chip-Seq_NPCs_Mouse0.70945623
172SOX9_24532713_ChIP-Seq_HFSC_Mouse0.70639300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis8.88539068
2MP0003136_yellow_coat_color7.38259171
3MP0005171_absent_coat_pigmentation7.14730010
4MP0009379_abnormal_foot_pigmentation6.74296389
5MP0002653_abnormal_ependyma_morphology5.29086337
6MP0002009_preneoplasia4.67212755
7MP0002139_abnormal_hepatobiliary_system4.53256414
8MP0002877_abnormal_melanocyte_morpholog4.48834925
9MP0003045_fibrosis4.39502372
10MP0005083_abnormal_biliary_tract4.31657835
11MP0003646_muscle_fatigue4.22521017
12MP0005085_abnormal_gallbladder_physiolo3.97794834
13MP0003890_abnormal_embryonic-extraembry3.89595888
14MP0010030_abnormal_orbit_morphology3.56053517
15MP0003879_abnormal_hair_cell3.51224442
16MP0002138_abnormal_hepatobiliary_system3.30126243
17MP0005084_abnormal_gallbladder_morpholo3.19987826
18MP0005670_abnormal_white_adipose2.89118419
19MP0002928_abnormal_bile_duct2.85004937
20MP0000569_abnormal_digit_pigmentation2.83945124
21MP0006292_abnormal_olfactory_placode2.72792379
22MP0008057_abnormal_DNA_replication2.69978404
23MP0006082_CNS_inflammation2.59333200
24MP0004134_abnormal_chest_morphology2.52035953
25MP0000749_muscle_degeneration2.43980464
26MP0003300_gastrointestinal_ulcer2.33265657
27MP0005365_abnormal_bile_salt2.26534761
28MP0003195_calcinosis2.22936605
29MP0000733_abnormal_muscle_development2.14136268
30MP0005410_abnormal_fertilization2.11649503
31MP0002168_other_aberrant_phenotype1.89761394
32MP0004808_abnormal_hematopoietic_stem1.84444149
33MP0002938_white_spotting1.82544771
34MP0000462_abnormal_digestive_system1.82229553
35MP0005075_abnormal_melanosome_morpholog1.81753755
36MP0009384_cardiac_valve_regurgitation1.80227471
37MP0003878_abnormal_ear_physiology1.68606804
38MP0005377_hearing/vestibular/ear_phenot1.68606804
39MP0000613_abnormal_salivary_gland1.67326822
40MP0002006_tumorigenesis1.64649113
41MP0001501_abnormal_sleep_pattern1.64357157
42MP0005167_abnormal_blood-brain_barrier1.62175632
43MP0002332_abnormal_exercise_endurance1.60694704
44MP0003252_abnormal_bile_duct1.58057638
45MP0002166_altered_tumor_susceptibility1.57040875
46MP0003690_abnormal_glial_cell1.54593753
47MP0004147_increased_porphyrin_level1.50402499
48MP0000762_abnormal_tongue_morphology1.43138149
49MP0002735_abnormal_chemical_nociception1.41915089
50MP0006054_spinal_hemorrhage1.39389512
51MP0003705_abnormal_hypodermis_morpholog1.37359713
52MP0001188_hyperpigmentation1.37187162
53MP0010368_abnormal_lymphatic_system1.29636699
54MP0003943_abnormal_hepatobiliary_system1.28696147
55MP0005395_other_phenotype1.28681031
56MP0005409_darkened_coat_color1.28471289
57MP0003566_abnormal_cell_adhesion1.28267524
58MP0004233_abnormal_muscle_weight1.26165173
59MP0001849_ear_inflammation1.21179939
60MP0004272_abnormal_basement_membrane1.20237839
61MP0003137_abnormal_impulse_conducting1.19862461
62MP0009278_abnormal_bone_marrow1.18947439
63MP0002075_abnormal_coat/hair_pigmentati1.18536621
64MP0005164_abnormal_response_to1.18425455
65MP0005166_decreased_susceptibility_to1.16571172
66MP0005623_abnormal_meninges_morphology1.15864475
67MP0002254_reproductive_system_inflammat1.14167792
68MP0001270_distended_abdomen1.13800918
69MP0000858_altered_metastatic_potential1.13310903
70MP0002277_abnormal_respiratory_mucosa1.12688509
71MP0000678_abnormal_parathyroid_gland1.11835158
72MP0005257_abnormal_intraocular_pressure1.10385293
73MP0004264_abnormal_extraembryonic_tissu1.08529475
74MP0004510_myositis1.08521871
75MP0005330_cardiomyopathy1.05617960
76MP0001764_abnormal_homeostasis1.05544003
77MP0001905_abnormal_dopamine_level1.05516032
78MP0000049_abnormal_middle_ear1.04742590
79MP0001177_atelectasis1.03599806
80MP0003283_abnormal_digestive_organ1.00904803
81MP0001346_abnormal_lacrimal_gland1.00336275
82MP0003786_premature_aging0.99789112
83MP0002095_abnormal_skin_pigmentation0.98868001
84MP0003950_abnormal_plasma_membrane0.96742231
85MP0003938_abnormal_ear_development0.96565721
86MP0002734_abnormal_mechanical_nocicepti0.96186666
87MP0000427_abnormal_hair_cycle0.94886252
88MP0004859_abnormal_synaptic_plasticity0.94671988
89MP0003941_abnormal_skin_development0.92943675
90MP0004484_altered_response_of0.92938259
91MP0003011_delayed_dark_adaptation0.92822127
92MP0005360_urolithiasis0.91659036
93MP0002249_abnormal_larynx_morphology0.89853883
94MP0001486_abnormal_startle_reflex0.88993502
95MP0001545_abnormal_hematopoietic_system0.86914504
96MP0005397_hematopoietic_system_phenotyp0.86914504
97MP0002269_muscular_atrophy0.86218972
98MP0010155_abnormal_intestine_physiology0.85999688
99MP0004381_abnormal_hair_follicle0.85328049
100MP0002160_abnormal_reproductive_system0.82772399
101MP0001879_abnormal_lymphatic_vessel0.82070301
102MP0001984_abnormal_olfaction0.81725814
103MP0008569_lethality_at_weaning0.81219104
104MP0004043_abnormal_pH_regulation0.80047744
105MP0005408_hypopigmentation0.79231132
106MP0004742_abnormal_vestibular_system0.77911905
107MP0008875_abnormal_xenobiotic_pharmacok0.77011811
108MP0001186_pigmentation_phenotype0.75184383
109MP0005451_abnormal_body_composition0.74122128
110MP0002272_abnormal_nervous_system0.73813505
111MP0005551_abnormal_eye_electrophysiolog0.73731540
112MP0002132_abnormal_respiratory_system0.72731284
113MP0005174_abnormal_tail_pigmentation0.72091412
114MP0000566_synostosis0.71949631
115MP0009115_abnormal_fat_cell0.71907750
116MP0000534_abnormal_ureter_morphology0.70713585
117MP0005266_abnormal_metabolism0.70466968
118MP0003186_abnormal_redox_activity0.70370187
119MP0000579_abnormal_nail_morphology0.69023175
120MP0009785_altered_susceptibility_to0.68701639
121MP0003787_abnormal_imprinting0.68152139
122MP0003698_abnormal_male_reproductive0.67049144
123MP0009046_muscle_twitch0.66604736
124MP0001324_abnormal_eye_pigmentation0.66476795
125MP0008770_decreased_survivor_rate0.66449853
126MP0004883_abnormal_blood_vessel0.65389530
127MP0000490_abnormal_crypts_of0.64459982
128MP0001963_abnormal_hearing_physiology0.64402177
129MP0005319_abnormal_enzyme/_coenzyme0.63232413
130MP0003279_aneurysm0.63109689
131MP0009745_abnormal_behavioral_response0.62534829
132MP0000372_irregular_coat_pigmentation0.61706039
133MP0000163_abnormal_cartilage_morphology0.61136041
134MP0009250_abnormal_appendicular_skeleto0.60626300
135MP0002971_abnormal_brown_adipose0.60122045
136MP0002229_neurodegeneration0.59618148
137MP0000026_abnormal_inner_ear0.55422390
138MP0001986_abnormal_taste_sensitivity0.53252390
139MP0002876_abnormal_thyroid_physiology0.52986510
140MP0001968_abnormal_touch/_nociception0.51942490
141MP0003724_increased_susceptibility_to0.51689961
142MP0003385_abnormal_body_wall0.51573305
143MP0001970_abnormal_pain_threshold0.51277065
144MP0003315_abnormal_perineum_morphology0.51059544
145MP0002736_abnormal_nociception_after0.50923736
146MP0002092_abnormal_eye_morphology0.49905060
147MP0005646_abnormal_pituitary_gland0.48643399
148MP0005376_homeostasis/metabolism_phenot0.48603794
149MP0001929_abnormal_gametogenesis0.48065088
150MP0010352_gastrointestinal_tract_polyps0.47968629
151MP0004130_abnormal_muscle_cell0.47564504
152MP0001485_abnormal_pinna_reflex0.47260576
153MP0002396_abnormal_hematopoietic_system0.46642011
154MP0009764_decreased_sensitivity_to0.46474385
155MP0002064_seizures0.45732959
156MP0005253_abnormal_eye_physiology0.44798041
157MP0003718_maternal_effect0.43611481
158MP0002733_abnormal_thermal_nociception0.42843883
159MP0001661_extended_life_span0.41115100
160MP0010329_abnormal_lipoprotein_level0.38741793
161MP0002572_abnormal_emotion/affect_behav0.38492878
162MP0004142_abnormal_muscle_tone0.38440744
163MP0008872_abnormal_physiological_respon0.37972994
164MP0002118_abnormal_lipid_homeostasis0.37868761
165MP0000230_abnormal_systemic_arterial0.36607236
166MP0008874_decreased_physiological_sensi0.35941383
167MP0002161_abnormal_fertility/fecundity0.35005924
168MP0005620_abnormal_muscle_contractility0.34142276
169MP0000371_diluted_coat_color0.32713470
170MP0005332_abnormal_amino_acid0.29654264
171MP0003937_abnormal_limbs/digits/tail_de0.29530865
172MP0002210_abnormal_sex_determination0.29144278
173MP0005535_abnormal_body_temperature0.27790891
174MP0006276_abnormal_autonomic_nervous0.26613783

Predicted human phenotypes

RankGene SetZ-score
1Amelogenesis imperfecta (HP:0000705)9.07042275
2Focal motor seizures (HP:0011153)8.71912582
3Acanthocytosis (HP:0001927)7.01846281
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.76838521
5Parakeratosis (HP:0001036)6.65838057
6Abnormal pancreas size (HP:0012094)6.62995225
7Urethral obstruction (HP:0000796)5.82334250
8Dialeptic seizures (HP:0011146)5.39854382
9Hypoplasia of the uterus (HP:0000013)4.65353890
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.59133715
11Ulnar claw (HP:0001178)4.54717131
12Axonal loss (HP:0003447)4.54084673
13Aplastic anemia (HP:0001915)4.52123117
14Abnormal tarsal ossification (HP:0008369)4.49483286
15Unilateral renal agenesis (HP:0000122)4.31116612
16Focal seizures (HP:0007359)4.24360014
17Abnormal number of erythroid precursors (HP:0012131)4.19630123
18Hydroureter (HP:0000072)4.03124877
19Proximal tubulopathy (HP:0000114)3.93578365
20Congenital ichthyosiform erythroderma (HP:0007431)3.87800784
21Spontaneous hematomas (HP:0007420)3.86635772
22Severe visual impairment (HP:0001141)3.83813952
23Pancreatic cysts (HP:0001737)3.81376407
24Facial shape deformation (HP:0011334)3.73669724
25Potter facies (HP:0002009)3.73669724
26Aplasia/Hypoplasia of the uvula (HP:0010293)3.71832640
27Proximal amyotrophy (HP:0007126)3.64607786
28Colon cancer (HP:0003003)3.62858292
29Abnormality of cells of the erythroid lineage (HP:0012130)3.61172050
30Abnormal foot bone ossification (HP:0010675)3.59270309
31Abnormality of purine metabolism (HP:0004352)3.56564761
32Difficulty walking (HP:0002355)3.54722501
33Pendular nystagmus (HP:0012043)3.54639309
34Rectal prolapse (HP:0002035)3.54052689
35Abnormality of macular pigmentation (HP:0008002)3.53704111
36Abnormality of monocarboxylic acid metabolism (HP:0010996)3.44297099
37Hematochezia (HP:0002573)3.35735183
38Mediastinal lymphadenopathy (HP:0100721)3.34686583
39Erythroderma (HP:0001019)3.32765840
40Aplasia/hypoplasia of the uterus (HP:0008684)3.27464350
41Chorioretinal atrophy (HP:0000533)3.23133644
42Opisthotonus (HP:0002179)3.21643792
43Upper limb muscle weakness (HP:0003484)3.19007996
44Bicornuate uterus (HP:0000813)3.18432379
45Abnormality of the hepatic vasculature (HP:0006707)3.18281885
46Poikilocytosis (HP:0004447)3.12421955
47Gout (HP:0001997)3.10741537
48Congenital, generalized hypertrichosis (HP:0004540)3.02299537
49Abnormality of the renal cortex (HP:0011035)3.01219929
50Renal cortical cysts (HP:0000803)2.99987472
51Thrombocytosis (HP:0001894)2.99301797
52Esophageal varix (HP:0002040)2.99091318
53Scapular winging (HP:0003691)2.96565412
54Action tremor (HP:0002345)2.92195461
55Bilateral sensorineural hearing impairment (HP:0008619)2.90244751
56Abnormality of the vocal cords (HP:0008777)2.89423541
57Portal hypertension (HP:0001409)2.88388341
58Submucous cleft hard palate (HP:0000176)2.87612725
59Broad ribs (HP:0000885)2.87471985
60Glucose intolerance (HP:0000833)2.85545544
61Enlarged kidneys (HP:0000105)2.81388911
62Glycosuria (HP:0003076)2.80174849
63Abnormality of urine glucose concentration (HP:0011016)2.80174849
64Exocrine pancreatic insufficiency (HP:0001738)2.77687386
65Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74062421
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74062421
67Absence seizures (HP:0002121)2.70474343
68Hypergonadotropic hypogonadism (HP:0000815)2.69094917
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66853555
70Cupped ribs (HP:0000887)2.66349284
71Toxemia of pregnancy (HP:0100603)2.62014775
72Prostate neoplasm (HP:0100787)2.56331865
73Abnormality of nucleobase metabolism (HP:0010932)2.53103864
74Overlapping toe (HP:0001845)2.52535257
75Conjunctival telangiectasia (HP:0000524)2.52518876
76Methylmalonic acidemia (HP:0002912)2.50316259
77Prolonged neonatal jaundice (HP:0006579)2.50275861
78Renal dysplasia (HP:0000110)2.49875722
79Asymmetric septal hypertrophy (HP:0001670)2.49330337
80Down-sloping shoulders (HP:0200021)2.48012331
81Aplasia involving bones of the upper limbs (HP:0009823)2.47393002
82Aplasia of the phalanges of the hand (HP:0009802)2.47393002
83Aplasia involving bones of the extremities (HP:0009825)2.47393002
84Generalized aminoaciduria (HP:0002909)2.47118980
85Distal lower limb amyotrophy (HP:0008944)2.44365066
86Shawl scrotum (HP:0000049)2.43805270
87Reduced antithrombin III activity (HP:0001976)2.41392866
88Renal Fanconi syndrome (HP:0001994)2.40835161
89Stillbirth (HP:0003826)2.40649180
90Abnormality of the renal medulla (HP:0100957)2.38386557
91Genetic anticipation (HP:0003743)2.37898152
92Type I transferrin isoform profile (HP:0003642)2.37012986
9311 pairs of ribs (HP:0000878)2.36521021
94Mutism (HP:0002300)2.32320744
95Gangrene (HP:0100758)2.31964627
96Generalized amyotrophy (HP:0003700)2.30673598
97Premature rupture of membranes (HP:0001788)2.29879309
98Reticulocytopenia (HP:0001896)2.28851770
99Hyperuricemia (HP:0002149)2.28282727
100Increased purine levels (HP:0004368)2.28282727
101Progressive cerebellar ataxia (HP:0002073)2.28156465
102Ureteral stenosis (HP:0000071)2.27929543
103Abnormality of carpal bone ossification (HP:0006257)2.26510183
104Distal lower limb muscle weakness (HP:0009053)2.25079315
105Synostosis of carpal bones (HP:0005048)2.22532566
106Atonic seizures (HP:0010819)2.22494171
107Annular pancreas (HP:0001734)2.21062844
108Hypoplastic iliac wings (HP:0002866)2.20508621
109Lipid accumulation in hepatocytes (HP:0006561)2.20305871
110Basal ganglia calcification (HP:0002135)2.19839977
111Ulnar bowing (HP:0003031)2.19770350
112Cerebellar dysplasia (HP:0007033)2.19769498
113Chronic diarrhea (HP:0002028)2.18710279
114Sprengel anomaly (HP:0000912)2.16897835
115Abnormality of potassium homeostasis (HP:0011042)2.16599273
116Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15730973
117Hyperkalemia (HP:0002153)2.15556214
118Severe Myopia (HP:0011003)2.15353485
119Nausea (HP:0002018)2.15314027
120Hypoalphalipoproteinemia (HP:0003233)2.14503497
121Retinitis pigmentosa (HP:0000510)2.14047004
122Autoimmune hemolytic anemia (HP:0001890)2.13288365
123Tarsal synostosis (HP:0008368)2.11855810
124Increased hepatocellular lipid droplets (HP:0006565)2.11639286
125Preauricular pit (HP:0004467)2.11002217
126Periauricular skin pits (HP:0100277)2.11002217
127Hypokalemia (HP:0002900)2.10898973
128Flat acetabular roof (HP:0003180)2.10756235
129Postural instability (HP:0002172)2.10613520
130Vertebral arch anomaly (HP:0008438)2.10432551
131Radial bowing (HP:0002986)2.09763284
132Decreased circulating renin level (HP:0003351)2.09712316
133Hypoalbuminemia (HP:0003073)2.07448102
134Abnormal albumin level (HP:0012116)2.07448102
135Abnormality of the basal ganglia (HP:0002134)2.07410821
136Tubular atrophy (HP:0000092)2.07357607
137Intrahepatic cholestasis (HP:0001406)2.07131500
138Gaze-evoked nystagmus (HP:0000640)2.06664391
139Macular degeneration (HP:0000608)2.03749218
140Abnormality of the pericardium (HP:0001697)2.03434775
141Nephronophthisis (HP:0000090)2.03163155
142Abnormality of the vitamin B12 metabolism (HP:0004341)2.02181929
143Abnormal ciliary motility (HP:0012262)2.01451375
144Petechiae (HP:0000967)2.00356784
145Ectopia lentis (HP:0001083)2.00330107
146Increased mean platelet volume (HP:0011877)1.99490585
147Increased corneal curvature (HP:0100692)1.98860125
148Keratoconus (HP:0000563)1.98860125
149Cystic liver disease (HP:0006706)1.98793355
150Abnormal glucose tolerance (HP:0001952)1.98788835
151Tubulointerstitial fibrosis (HP:0005576)1.97293760
152Bony spicule pigmentary retinopathy (HP:0007737)1.96910625
153Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95772677
154Upper motor neuron abnormality (HP:0002127)1.94346109
155Oligodontia (HP:0000677)1.94274080
156Dynein arm defect of respiratory motile cilia (HP:0012255)1.94220958
157Absent/shortened dynein arms (HP:0200106)1.94220958
158Synostosis involving bones of the lower limbs (HP:0009138)1.93464907
159Synostosis involving bones of the feet (HP:0009140)1.93464907
160Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91691954
161Attenuation of retinal blood vessels (HP:0007843)1.91596040
162Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91505261
163Increased intramyocellular lipid droplets (HP:0012240)1.90448398
164Chronic hepatic failure (HP:0100626)1.89623595
165Abnormal platelet volume (HP:0011876)1.89141705
166Nasolacrimal duct obstruction (HP:0000579)1.88237860
167Dehydration (HP:0001944)1.87108583
168Hypoglycemic coma (HP:0001325)1.87077243
169Type I diabetes mellitus (HP:0100651)1.86187398
170Horizontal nystagmus (HP:0000666)1.85757517
171Abnormality of vitamin B metabolism (HP:0004340)1.85532071
172Renal hypoplasia (HP:0000089)1.85297261
173Ureteral obstruction (HP:0006000)1.84675919
174Onion bulb formation (HP:0003383)1.84410069
175Abnormal hemoglobin (HP:0011902)1.83404817
176Ventricular fibrillation (HP:0001663)1.81292085
177Aplasia/Hypoplasia of the breasts (HP:0010311)1.81164849
178Lower limb amyotrophy (HP:0007210)1.81104871
179Hypolipoproteinemia (HP:0010981)1.79997759
180Dysmetric saccades (HP:0000641)1.79364337
181Chromsome breakage (HP:0040012)1.77844152
182Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.77598212
183Abnormal ossification of hand bones (HP:0005921)1.77411946
184IgM deficiency (HP:0002850)1.77245098
185Breast aplasia (HP:0100783)1.77175687
186Abnormality of the shoulder girdle musculature (HP:0001435)1.75861477
187Purpura (HP:0000979)1.75196593
188Increased neuronal autofluorescent lipopigment (HP:0002074)1.74932916
189Lack of skin elasticity (HP:0100679)1.74472206
190Abnormality of the intrinsic pathway (HP:0010989)1.74319990
191Segmental peripheral demyelination/remyelination (HP:0003481)1.73839046
192Abnormal hand bone ossification (HP:0010660)1.73073551
193Abnormal protein glycosylation (HP:0012346)1.70141182
194Abnormal glycosylation (HP:0012345)1.70141182
195Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70141182
196Abnormal protein N-linked glycosylation (HP:0012347)1.70141182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL27.08418438
2LATS26.62828191
3BCR4.29871121
4TRPM73.88787629
5STK38L3.49603314
6MAP2K33.15762755
7IRAK33.06595459
8PRKD33.00243840
9MAP2K62.81740491
10TLK12.67444132
11ACVR1B2.51350847
12IRAK22.37391843
13FRK2.22716287
14NLK2.20270557
15STK32.10041796
16IRAK42.03021859
17LATS110.3807254
18MAP2K21.94624750
19BMPR1B1.91371090
20MELK1.87354009
21PIK3CG1.85524566
22IRAK11.83628075
23STK381.82532483
24CDK91.81058149
25TAOK21.73495622
26NME11.58779846
27STK161.56533116
28STK391.56278907
29CDK61.53049471
30PBK1.43439679
31EPHB21.42417614
32EPHA41.40120251
33PASK1.37879989
34OXSR11.37005893
35NUAK11.36346914
36MST1R1.35762329
37EPHA21.35079536
38HIPK21.34141783
39CLK11.32543921
40MAP3K31.21267464
41TGFBR21.19331993
42PINK11.15420791
43PDPK11.13206391
44MAP3K141.12324349
45PLK41.11383233
46EIF2AK21.10793059
47ERBB21.10406688
48MAP3K21.06040309
49CDK191.05261551
50MAPKAPK51.00917147
51CCNB10.99475400
52ERBB40.99176843
53NEK20.96103415
54KSR20.91444795
55RIPK40.90755203
56TAF10.88874562
57PKN10.85637685
58CHEK20.78507059
59GRK70.78244222
60SIK30.76819035
61SIK20.75133237
62NEK60.72560737
63ADRBK20.72485960
64ALK0.70400642
65EPHB10.69951832
66TGFBR10.68100852
67ZAK0.65066603
68JAK10.61394555
69PTK60.59118376
70ADRBK10.59086897
71BTK0.59077043
72INSRR0.58587686
73CDK80.58533794
74LMTK20.58338637
75CSNK1A1L0.57956668
76PRKD10.53989042
77CSNK1G30.53432960
78CDK30.53401099
79PLK20.53029281
80NTRK30.52440820
81NEK90.50060897
82TTK0.48609345
83STK40.48458251
84RIPK10.48093661
85ATR0.47880637
86FER0.47127877
87VRK10.46992061
88CDK40.43622470
89PIK3CA0.43127633
90WNK40.42622498
91MOS0.41146500
92GRK50.40832377
93PIM20.40507742
94MAP2K10.40432458
95STK110.38266225
96MAP2K40.37232629
97CDK150.37088923
98CDK180.36373203
99TNK20.35358643
100CSNK1G20.34734270
101CAMK10.34469129
102DAPK20.33262109
103EIF2AK30.32764994
104TIE10.32460299
105CAMKK10.32015982
106MAPK40.31899252
107ERBB30.31189522
108CSNK1G10.29307857
109LIMK10.28972018
110MKNK20.28491914
111AURKB0.28381125
112PRKAA20.27564770
113TSSK60.27523498
114EPHA30.27459290
115PRKCH0.26430131
116PLK10.25589086
117CDK11A0.25356836
118STK100.25231231
119FES0.25056487
120CSNK1D0.24850289
121PIM10.24728790
122CDK50.24525691
123PTK2B0.23903966
124PRKCE0.23567442
125PRKCQ0.23101492
126TESK20.23048820
127PRKG20.23028541
128CDK140.22810897
129MAP3K70.22783294
130CAMK1D0.22662993
131CAMK2B0.21015408
132TXK0.20846363
133SGK20.20796034
134MET0.19506114
135CAMK2A0.19076122
136MAPK110.19037277
137TNIK0.18824984
138GRK10.18247002
139PRKCD0.17953318
140PRKCG0.16387389
141TAOK30.15880009
142PDK10.15156875
143MAP4K20.14057427
144TEC0.09999819
145PRKACA0.09064557
146ABL10.08764528
147OBSCN0.08761730
148DDR20.08378226
149PRKACB0.08320719
150ITK0.06643062
151MAPK10.04734142
152MAPK30.04256387
153MYLK0.03731266
154PRKCI0.03297211
155AKT20.02074453
156BRD40.01433628
157BMPR20.01057974
158MATK0.00911885
159JAK20.00640538
160PRKG10.00603631
161MAP3K80.00584664
162NEK1-0.0490274
163RET-0.0452855
164CSNK1A1-0.0427411
165AKT1-0.0394670
166GSK3B-0.0350533
167PLK3-0.0259823
168PRKCB-0.0018485
169MAPK8-0.0013417

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004008.32378110
2Folate biosynthesis_Homo sapiens_hsa007904.84127831
3Phototransduction_Homo sapiens_hsa047444.09315259
4Malaria_Homo sapiens_hsa051443.77877700
5Sphingolipid metabolism_Homo sapiens_hsa006003.55128840
6Glycosaminoglycan degradation_Homo sapiens_hsa005313.38528969
7ABC transporters_Homo sapiens_hsa020103.26150734
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.24859832
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.16612670
10Intestinal immune network for IgA production_Homo sapiens_hsa046723.06136612
11Graft-versus-host disease_Homo sapiens_hsa053322.89273020
12African trypanosomiasis_Homo sapiens_hsa051432.82629474
13DNA replication_Homo sapiens_hsa030302.52211576
14Phenylalanine metabolism_Homo sapiens_hsa003602.40714294
15Dorso-ventral axis formation_Homo sapiens_hsa043202.39728523
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.35922517
17Taste transduction_Homo sapiens_hsa047422.14991181
18Ribosome_Homo sapiens_hsa030102.14958100
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.12670704
20Basal transcription factors_Homo sapiens_hsa030222.00099212
21Pertussis_Homo sapiens_hsa051331.96178886
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94866462
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.90808787
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.79642264
25Tryptophan metabolism_Homo sapiens_hsa003801.74485014
26Sulfur metabolism_Homo sapiens_hsa009201.73415792
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63207795
28Non-homologous end-joining_Homo sapiens_hsa034501.50897944
29Histidine metabolism_Homo sapiens_hsa003401.50683674
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48749375
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.47393459
32Bladder cancer_Homo sapiens_hsa052191.43009853
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33556801
34GABAergic synapse_Homo sapiens_hsa047271.30931541
35Retinol metabolism_Homo sapiens_hsa008301.30754912
36Salmonella infection_Homo sapiens_hsa051321.27219777
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.26696695
38Hematopoietic cell lineage_Homo sapiens_hsa046401.26093200
39Mineral absorption_Homo sapiens_hsa049781.24675381
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.24174051
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23798331
42Sulfur relay system_Homo sapiens_hsa041221.20999411
43Tight junction_Homo sapiens_hsa045301.19909580
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18328724
45Tyrosine metabolism_Homo sapiens_hsa003501.17189112
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.13956041
47One carbon pool by folate_Homo sapiens_hsa006701.12873890
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09722982
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.05540663
50Fatty acid elongation_Homo sapiens_hsa000621.01350693
51Complement and coagulation cascades_Homo sapiens_hsa046100.99068138
52Nitrogen metabolism_Homo sapiens_hsa009100.97624703
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96618985
54Vitamin digestion and absorption_Homo sapiens_hsa049770.96340664
55Olfactory transduction_Homo sapiens_hsa047400.95600697
56Chemical carcinogenesis_Homo sapiens_hsa052040.94273872
57Dilated cardiomyopathy_Homo sapiens_hsa054140.93990990
58Propanoate metabolism_Homo sapiens_hsa006400.88524881
59Rap1 signaling pathway_Homo sapiens_hsa040150.88524580
60Viral myocarditis_Homo sapiens_hsa054160.86594372
61Prion diseases_Homo sapiens_hsa050200.85402025
62Glycerolipid metabolism_Homo sapiens_hsa005610.84594100
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.82088946
64Chronic myeloid leukemia_Homo sapiens_hsa052200.78856117
65Bile secretion_Homo sapiens_hsa049760.77727158
66NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77104589
67HTLV-I infection_Homo sapiens_hsa051660.76324645
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75824084
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75082009
70Leishmaniasis_Homo sapiens_hsa051400.74145245
71Caffeine metabolism_Homo sapiens_hsa002320.73489519
72Starch and sucrose metabolism_Homo sapiens_hsa005000.71976788
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.71464171
74Butanoate metabolism_Homo sapiens_hsa006500.70017203
75GnRH signaling pathway_Homo sapiens_hsa049120.69506581
76Glioma_Homo sapiens_hsa052140.67953662
77Serotonergic synapse_Homo sapiens_hsa047260.67634241
78Glutathione metabolism_Homo sapiens_hsa004800.66115479
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65481998
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64996588
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64897249
82Pyruvate metabolism_Homo sapiens_hsa006200.63958311
83Ovarian steroidogenesis_Homo sapiens_hsa049130.63427159
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63365285
85Fatty acid degradation_Homo sapiens_hsa000710.63297900
86Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59027662
87Tuberculosis_Homo sapiens_hsa051520.58691435
88Non-small cell lung cancer_Homo sapiens_hsa052230.57597989
89cAMP signaling pathway_Homo sapiens_hsa040240.55890896
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.55432972
91Linoleic acid metabolism_Homo sapiens_hsa005910.54539090
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53908790
93Salivary secretion_Homo sapiens_hsa049700.53319274
94Hepatitis B_Homo sapiens_hsa051610.53226714
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51186145
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50201137
97Huntingtons disease_Homo sapiens_hsa050160.49781331
98Circadian entrainment_Homo sapiens_hsa047130.49683666
99Proteoglycans in cancer_Homo sapiens_hsa052050.49202197
100VEGF signaling pathway_Homo sapiens_hsa043700.49030506
101Arginine and proline metabolism_Homo sapiens_hsa003300.48997958
102beta-Alanine metabolism_Homo sapiens_hsa004100.48789939
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47463628
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46251877
105N-Glycan biosynthesis_Homo sapiens_hsa005100.46142473
106Hepatitis C_Homo sapiens_hsa051600.45446088
107Arachidonic acid metabolism_Homo sapiens_hsa005900.45118615
108Collecting duct acid secretion_Homo sapiens_hsa049660.44490252
109Melanoma_Homo sapiens_hsa052180.44343571
110Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43717510
111Galactose metabolism_Homo sapiens_hsa000520.43556769
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43360639
113Shigellosis_Homo sapiens_hsa051310.43210538
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43060769
115Adherens junction_Homo sapiens_hsa045200.41434921
116Herpes simplex infection_Homo sapiens_hsa051680.41432019
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41393053
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.41011765
119Amoebiasis_Homo sapiens_hsa051460.40656232
120Fatty acid biosynthesis_Homo sapiens_hsa000610.39970646
121Morphine addiction_Homo sapiens_hsa050320.38858580
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38256419
123Lysine degradation_Homo sapiens_hsa003100.37660123
124Nicotine addiction_Homo sapiens_hsa050330.36456889
125TNF signaling pathway_Homo sapiens_hsa046680.36419293
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34657770
127Calcium signaling pathway_Homo sapiens_hsa040200.34061139
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33993302
129Homologous recombination_Homo sapiens_hsa034400.33126032
130Measles_Homo sapiens_hsa051620.32860476
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32638133
132Viral carcinogenesis_Homo sapiens_hsa052030.31517192
133Glutamatergic synapse_Homo sapiens_hsa047240.30495450
134Thyroid hormone synthesis_Homo sapiens_hsa049180.30255094
135ErbB signaling pathway_Homo sapiens_hsa040120.29846145
136Gastric acid secretion_Homo sapiens_hsa049710.29631386
137Peroxisome_Homo sapiens_hsa041460.29043726
138Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28498130
139TGF-beta signaling pathway_Homo sapiens_hsa043500.28298113
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28169396
141Axon guidance_Homo sapiens_hsa043600.27950614
142Metabolic pathways_Homo sapiens_hsa011000.27674400
143ECM-receptor interaction_Homo sapiens_hsa045120.27458928
144Fatty acid metabolism_Homo sapiens_hsa012120.26660716
145PPAR signaling pathway_Homo sapiens_hsa033200.25919758
146alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22381383
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21307142
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19871071
149Hippo signaling pathway_Homo sapiens_hsa043900.19170062
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.18762495
151Oocyte meiosis_Homo sapiens_hsa041140.18308772
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.17610046
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.15624865
154Insulin secretion_Homo sapiens_hsa049110.14701625
155Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12938887

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