OPRK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dopamine transport (GO:0015872)5.92028170
2dopamine biosynthetic process (GO:0042416)5.45943267
3synaptic transmission, dopaminergic (GO:0001963)5.31101718
4prepulse inhibition (GO:0060134)5.17580191
5neuron cell-cell adhesion (GO:0007158)4.76275920
6mating behavior (GO:0007617)4.74326292
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.57120504
8vocalization behavior (GO:0071625)4.53481607
9catecholamine transport (GO:0051937)4.52382816
10behavioral response to nicotine (GO:0035095)4.46559258
11response to amphetamine (GO:0001975)4.43346951
12striatum development (GO:0021756)4.34230377
13female mating behavior (GO:0060180)4.25249942
14transmission of nerve impulse (GO:0019226)4.24008557
15response to histamine (GO:0034776)4.22995151
16drinking behavior (GO:0042756)4.19748991
17regulation of female receptivity (GO:0045924)4.14075071
18pyrimidine nucleobase catabolic process (GO:0006208)4.05672066
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.02543748
20regulation of dopamine metabolic process (GO:0042053)4.01676039
21regulation of catecholamine metabolic process (GO:0042069)4.01676039
22regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.00290807
23regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.00290807
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.99964362
25behavioral response to cocaine (GO:0048148)3.99532529
26serotonin metabolic process (GO:0042428)3.95200402
27kynurenine metabolic process (GO:0070189)3.89808148
28alkaloid metabolic process (GO:0009820)3.89300693
29neuron-neuron synaptic transmission (GO:0007270)3.88343090
30synaptic vesicle maturation (GO:0016188)3.84131592
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.83817727
32indolalkylamine metabolic process (GO:0006586)3.82008414
33tryptophan metabolic process (GO:0006568)3.80133183
34synaptic vesicle exocytosis (GO:0016079)3.76242607
35primary amino compound metabolic process (GO:1901160)3.66229331
36somatic hypermutation of immunoglobulin genes (GO:0016446)3.65468674
37somatic diversification of immune receptors via somatic mutation (GO:0002566)3.65468674
38regulation of glutamate receptor signaling pathway (GO:1900449)3.62637831
39indole-containing compound catabolic process (GO:0042436)3.59072686
40indolalkylamine catabolic process (GO:0046218)3.59072686
41tryptophan catabolic process (GO:0006569)3.59072686
42positive regulation of synaptic transmission, GABAergic (GO:0032230)3.56072292
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.54501974
44regulation of glutamate secretion (GO:0014048)3.54327717
45protein localization to synapse (GO:0035418)3.53761120
46response to insecticide (GO:0017085)3.52619606
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.51552919
48ATP synthesis coupled proton transport (GO:0015986)3.51552919
49neurotransmitter secretion (GO:0007269)3.50604411
50response to cocaine (GO:0042220)3.48461975
51aggressive behavior (GO:0002118)3.48261045
52indole-containing compound metabolic process (GO:0042430)3.47524799
53regulation of long-term neuronal synaptic plasticity (GO:0048169)3.47363684
54intraspecies interaction between organisms (GO:0051703)3.46235147
55social behavior (GO:0035176)3.46235147
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.42522757
57regulation of protein kinase A signaling (GO:0010738)3.42000168
58response to pheromone (GO:0019236)3.39344234
59synaptic transmission, glutamatergic (GO:0035249)3.38255753
60auditory behavior (GO:0031223)3.37965694
61neurotransmitter transport (GO:0006836)3.37725777
62neuronal ion channel clustering (GO:0045161)3.37724772
63regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36590811
64neurotransmitter biosynthetic process (GO:0042136)3.35778817
65glutamate receptor signaling pathway (GO:0007215)3.34706338
66regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.34483720
67regulation of neurotransmitter uptake (GO:0051580)3.33762543
68locomotory exploration behavior (GO:0035641)3.33673099
69gamma-aminobutyric acid signaling pathway (GO:0007214)3.32917099
70regulation of synaptic vesicle exocytosis (GO:2000300)3.32909887
71* opioid receptor signaling pathway (GO:0038003)3.32698390
72glutamate secretion (GO:0014047)3.32202312
73regulation of synapse structural plasticity (GO:0051823)3.31108072
74negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.30020925
75negative regulation of neurotransmitter transport (GO:0051589)3.29044428
76protein polyglutamylation (GO:0018095)3.25268199
77nucleobase catabolic process (GO:0046113)3.25013084
78presynaptic membrane assembly (GO:0097105)3.23447179
79adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.22641017
80regulation of neurotransmitter levels (GO:0001505)3.21756599
81regulation of neuronal synaptic plasticity (GO:0048168)3.21679888
82negative regulation of systemic arterial blood pressure (GO:0003085)3.18507551
83negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16647848
84multi-organism reproductive behavior (GO:0044705)3.16044713
85regulation of uterine smooth muscle contraction (GO:0070472)3.15830280
86response to auditory stimulus (GO:0010996)3.15298664
87regulation of excitatory postsynaptic membrane potential (GO:0060079)3.15129929
88synapse assembly (GO:0007416)3.10686272
89regulation of dopamine secretion (GO:0014059)3.10597909
90positive regulation of synapse assembly (GO:0051965)3.08734495
91response to amine (GO:0014075)3.07799068
92anterograde axon cargo transport (GO:0008089)3.07652613
93neuron recognition (GO:0008038)3.06842966
94catecholamine biosynthetic process (GO:0042423)3.06208659
95catechol-containing compound biosynthetic process (GO:0009713)3.06208659
96dopamine metabolic process (GO:0042417)3.05552040
97gamma-aminobutyric acid transport (GO:0015812)3.05334213
98epithelial cilium movement (GO:0003351)3.05326662
99membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05094432
100regulation of postsynaptic membrane potential (GO:0060078)3.04611443
101neuronal action potential propagation (GO:0019227)3.02984617
102neuromuscular process controlling posture (GO:0050884)3.00969585
103reproductive behavior (GO:0019098)2.99463909
104monoamine transport (GO:0015844)2.99454645
105postsynaptic membrane organization (GO:0001941)2.98885517
106regulation of cAMP-dependent protein kinase activity (GO:2000479)2.98366394
107innervation (GO:0060384)2.97551722
108positive regulation of neurotransmitter transport (GO:0051590)2.96647763
109regulation of collateral sprouting (GO:0048670)2.96543440
110G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96134763
111neurotransmitter-gated ion channel clustering (GO:0072578)2.94842420
112long-term memory (GO:0007616)2.94652204
113presynaptic membrane organization (GO:0097090)2.94575757
114regulation of synaptic vesicle transport (GO:1902803)2.93811257
115sulfation (GO:0051923)2.93650679
116dendritic spine morphogenesis (GO:0060997)2.93367476
117neuronal action potential (GO:0019228)2.90381051
118neurofilament cytoskeleton organization (GO:0060052)2.90272256
119exploration behavior (GO:0035640)2.89998529
120dopamine receptor signaling pathway (GO:0007212)2.89314455
121limb bud formation (GO:0060174)2.88974018
122cerebellar Purkinje cell differentiation (GO:0021702)2.88368161
123regulation of action potential (GO:0098900)2.87754722
124membrane hyperpolarization (GO:0060081)2.87600066
125otic vesicle formation (GO:0030916)2.86810985
126regulation of synaptic transmission, GABAergic (GO:0032228)2.86762460
127inner ear receptor stereocilium organization (GO:0060122)2.86603431
128head development (GO:0060322)2.86346575
129regulation of synaptic transmission, glutamatergic (GO:0051966)2.85313492
130fucose catabolic process (GO:0019317)2.84661289
131L-fucose metabolic process (GO:0042354)2.84661289
132L-fucose catabolic process (GO:0042355)2.84661289
133positive regulation of renal sodium excretion (GO:0035815)2.84651043
134positive regulation of uterine smooth muscle contraction (GO:0070474)2.83961317
135regulation of sequestering of triglyceride (GO:0010889)2.83049750
136synaptic vesicle docking involved in exocytosis (GO:0016081)2.82108895
137pharyngeal system development (GO:0060037)2.81504484
138proline transport (GO:0015824)2.78731789
139cornea development in camera-type eye (GO:0061303)2.77934499
140negative chemotaxis (GO:0050919)2.77797696
141regulation of neurotransmitter transport (GO:0051588)2.77784708
142cell proliferation in forebrain (GO:0021846)2.76964748
143mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76874702
144mitochondrial respiratory chain complex I assembly (GO:0032981)2.76874702
145NADH dehydrogenase complex assembly (GO:0010257)2.76874702
146detection of light stimulus involved in sensory perception (GO:0050962)2.76730372
147detection of light stimulus involved in visual perception (GO:0050908)2.76730372
148positive regulation of cAMP-mediated signaling (GO:0043950)2.69362315
149sequestering of actin monomers (GO:0042989)2.65467864
150cellular response to sterol (GO:0036315)2.65322810
151retinal ganglion cell axon guidance (GO:0031290)2.64307756
152cellular response to cholesterol (GO:0071397)2.62461755
153thalamus development (GO:0021794)2.60702981
154protein complex biogenesis (GO:0070271)2.60431883
155somite development (GO:0061053)2.59942137
156neurotransmitter catabolic process (GO:0042135)2.58429138
157negative regulation of transcription regulatory region DNA binding (GO:2000678)2.56639913
158nephron epithelium morphogenesis (GO:0072088)2.55012961
159nephron tubule morphogenesis (GO:0072078)2.55012961
160resolution of meiotic recombination intermediates (GO:0000712)2.54221031
161parturition (GO:0007567)2.51992205
162negative regulation of multicellular organism growth (GO:0040015)2.49517923
163nonmotile primary cilium assembly (GO:0035058)2.47934640
164positive regulation of action potential (GO:0045760)2.46968814
165amine catabolic process (GO:0009310)2.44210659
166cellular biogenic amine catabolic process (GO:0042402)2.44210659
167startle response (GO:0001964)2.43740377
168photoreceptor cell development (GO:0042461)2.43294895
169epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.40398875
170cilium movement (GO:0003341)2.39551924
171tachykinin receptor signaling pathway (GO:0007217)2.39206058
172mitochondrial respiratory chain complex assembly (GO:0033108)2.38236426
173anterograde synaptic vesicle transport (GO:0048490)2.37270998
174spinal cord motor neuron differentiation (GO:0021522)2.37183521
175detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.37045177
176negative regulation of axon guidance (GO:1902668)2.36070713
177axonal fasciculation (GO:0007413)2.35373676
178phasic smooth muscle contraction (GO:0014821)2.34765896
179regulation of gene silencing by RNA (GO:0060966)2.34757055
180regulation of posttranscriptional gene silencing (GO:0060147)2.34757055
181regulation of gene silencing by miRNA (GO:0060964)2.34757055
182regulation of telomere maintenance (GO:0032204)2.34636064
183pituitary gland development (GO:0021983)2.34222606

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.70432829
2GBX2_23144817_ChIP-Seq_PC3_Human3.75688799
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98970582
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93235550
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90583382
6TAF15_26573619_Chip-Seq_HEK293_Human2.83591029
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60312433
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52363407
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46795957
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.45261104
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42691004
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42691004
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.42327426
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36595320
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35663136
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.34700641
17* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31527381
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27982934
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21507346
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.21251527
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16211833
22REST_21632747_ChIP-Seq_MESCs_Mouse2.15890163
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15347760
24EWS_26573619_Chip-Seq_HEK293_Human2.10332777
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.09350272
26DROSHA_22980978_ChIP-Seq_HELA_Human2.06791625
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05130376
28IGF1R_20145208_ChIP-Seq_DFB_Human2.02762079
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97746358
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.92875729
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.90315152
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.90007123
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.86061292
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83113640
35AR_21572438_ChIP-Seq_LNCaP_Human1.81086576
36* P300_19829295_ChIP-Seq_ESCs_Human1.78602035
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78561726
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78317176
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75493399
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.71139278
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67731573
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64866748
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.64522097
44RNF2_27304074_Chip-Seq_NSC_Mouse1.59967220
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57052142
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.56211588
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55994354
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.55698120
49FUS_26573619_Chip-Seq_HEK293_Human1.54392115
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54279488
51* SMAD3_21741376_ChIP-Seq_EPCs_Human1.52133657
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50820682
53VDR_22108803_ChIP-Seq_LS180_Human1.49996300
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46830625
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45916169
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45859078
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44674739
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42647583
59IRF1_19129219_ChIP-ChIP_H3396_Human1.42201592
60* PIAS1_25552417_ChIP-Seq_VCAP_Human1.41811613
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41365536
62* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39052183
63* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38296684
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37918398
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37918398
66* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36940358
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36670884
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36398151
69* FLI1_27457419_Chip-Seq_LIVER_Mouse1.36365677
70ER_23166858_ChIP-Seq_MCF-7_Human1.35480322
71* AR_25329375_ChIP-Seq_VCAP_Human1.32424449
72* NANOG_18555785_Chip-Seq_ESCs_Mouse1.32337937
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29684713
74CBP_20019798_ChIP-Seq_JUKART_Human1.29684713
75* RUNX2_22187159_ChIP-Seq_PCA_Human1.29359713
76* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25949782
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25443324
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.24508022
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24415302
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24243927
81* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23919263
82ZNF274_21170338_ChIP-Seq_K562_Hela1.23878593
83* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23356189
84STAT3_23295773_ChIP-Seq_U87_Human1.23039459
85* E2F1_18555785_Chip-Seq_ESCs_Mouse1.21981660
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21908099
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21257479
88TP53_18474530_ChIP-ChIP_U2OS_Human1.21191656
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17932375
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17781363
91JUN_21703547_ChIP-Seq_K562_Human1.16754582
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16276400
93BCAT_22108803_ChIP-Seq_LS180_Human1.15765656
94SOX2_19829295_ChIP-Seq_ESCs_Human1.15651869
95NANOG_19829295_ChIP-Seq_ESCs_Human1.15651869
96* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14955152
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14041148
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.13491980
99* P53_22387025_ChIP-Seq_ESCs_Mouse1.13437531
100* CMYC_18555785_Chip-Seq_ESCs_Mouse1.13215305
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12562828
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12560568
103* NFE2_27457419_Chip-Seq_LIVER_Mouse1.11724038
104MYC_18940864_ChIP-ChIP_HL60_Human1.11071934
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11024115
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.10197924
107* TCF4_23295773_ChIP-Seq_U87_Human1.09989492
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09150808
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08803517
110KDM2B_26808549_Chip-Seq_REH_Human1.05327261
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04216867
112* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03563463
113* P300_18555785_Chip-Seq_ESCs_Mouse1.03266591
114* SOX2_18555785_Chip-Seq_ESCs_Mouse1.02992745
115TP53_16413492_ChIP-PET_HCT116_Human1.02150483
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02142473
117* STAT3_18555785_Chip-Seq_ESCs_Mouse1.02125849
118ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01566520
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01510049
120* SMAD4_21741376_ChIP-Seq_EPCs_Human1.00716375
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.00640510
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99183528
123TCF4_22108803_ChIP-Seq_LS180_Human0.99154448
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98272432
125* TP53_22573176_ChIP-Seq_HFKS_Human0.97977154
126TAL1_26923725_Chip-Seq_HPCs_Mouse0.97302339
127RXR_22108803_ChIP-Seq_LS180_Human0.97289868
128* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96340897

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.78412991
2MP0004859_abnormal_synaptic_plasticity3.95713690
3MP0001529_abnormal_vocalization3.51329190
4MP0003635_abnormal_synaptic_transmissio3.29966942
5* MP0009745_abnormal_behavioral_response3.26297009
6MP0006276_abnormal_autonomic_nervous3.13379438
7MP0001905_abnormal_dopamine_level3.13285840
8MP0002822_catalepsy3.00825852
9MP0009046_muscle_twitch2.97287017
10MP0005423_abnormal_somatic_nervous2.83898043
11MP0005645_abnormal_hypothalamus_physiol2.78125481
12MP0001984_abnormal_olfaction2.76664937
13* MP0002063_abnormal_learning/memory/cond2.75760345
14MP0002064_seizures2.72813345
15MP0001968_abnormal_touch/_nociception2.64703691
16MP0001486_abnormal_startle_reflex2.61830739
17MP0002572_abnormal_emotion/affect_behav2.58294993
18MP0005646_abnormal_pituitary_gland2.50459670
19MP0001440_abnormal_grooming_behavior2.38402021
20MP0004133_heterotaxia2.37606986
21MP0005499_abnormal_olfactory_system2.34459392
22MP0005394_taste/olfaction_phenotype2.34459392
23MP0003122_maternal_imprinting2.27257201
24MP0001501_abnormal_sleep_pattern2.18270659
25MP0005379_endocrine/exocrine_gland_phen2.16021856
26MP0002272_abnormal_nervous_system2.15225487
27MP0002736_abnormal_nociception_after2.06369125
28MP0002557_abnormal_social/conspecific_i2.02848391
29MP0008877_abnormal_DNA_methylation2.00841556
30MP0006292_abnormal_olfactory_placode1.98569208
31MP0002734_abnormal_mechanical_nocicepti1.97624607
32MP0002653_abnormal_ependyma_morphology1.97163694
33MP0001188_hyperpigmentation1.96979114
34MP0004924_abnormal_behavior1.94819459
35MP0005386_behavior/neurological_phenoty1.94819459
36MP0004270_analgesia1.92147765
37MP0002067_abnormal_sensory_capabilities1.85497889
38MP0006072_abnormal_retinal_apoptosis1.80923664
39MP0002735_abnormal_chemical_nociception1.78006569
40MP0001502_abnormal_circadian_rhythm1.74016238
41MP0003011_delayed_dark_adaptation1.71200191
42MP0008872_abnormal_physiological_respon1.70344592
43MP0002733_abnormal_thermal_nociception1.66233333
44* MP0001970_abnormal_pain_threshold1.63147917
45MP0005409_darkened_coat_color1.61657951
46MP0003283_abnormal_digestive_organ1.61538799
47MP0003195_calcinosis1.59583850
48MP0004145_abnormal_muscle_electrophysio1.58245463
49MP0003787_abnormal_imprinting1.58159652
50MP0004142_abnormal_muscle_tone1.52627846
51MP0002928_abnormal_bile_duct1.49352513
52MP0004742_abnormal_vestibular_system1.48216569
53MP0004147_increased_porphyrin_level1.47622104
54MP0005253_abnormal_eye_physiology1.46830779
55MP0005248_abnormal_Harderian_gland1.45286164
56MP0002184_abnormal_innervation1.44350279
57MP0001346_abnormal_lacrimal_gland1.43941869
58MP0000566_synostosis1.43569105
59MP0002163_abnormal_gland_morphology1.42994500
60MP0002751_abnormal_autonomic_nervous1.33263976
61MP0000778_abnormal_nervous_system1.26665587
62MP0003942_abnormal_urinary_system1.25569192
63MP0003119_abnormal_digestive_system1.24989303
64MP0003937_abnormal_limbs/digits/tail_de1.24245901
65MP0000372_irregular_coat_pigmentation1.23209728
66MP0008789_abnormal_olfactory_epithelium1.22563273
67MP0000049_abnormal_middle_ear1.21617265
68MP0002837_dystrophic_cardiac_calcinosis1.21131928
69MP0003890_abnormal_embryonic-extraembry1.19539676
70MP0000631_abnormal_neuroendocrine_gland1.19225172
71MP0002938_white_spotting1.18808072
72MP0001986_abnormal_taste_sensitivity1.17930175
73MP0003938_abnormal_ear_development1.17515208
74MP0008569_lethality_at_weaning1.16621751
75* MP0002066_abnormal_motor_capabilities/c1.12041678
76MP0003879_abnormal_hair_cell1.11304808
77MP0005084_abnormal_gallbladder_morpholo1.10871610
78MP0004130_abnormal_muscle_cell1.10078403
79MP0005535_abnormal_body_temperature1.07248904
80MP0005187_abnormal_penis_morphology1.04631143
81MP0002882_abnormal_neuron_morphology1.03742494
82MP0003941_abnormal_skin_development0.99791466
83MP0002876_abnormal_thyroid_physiology0.98764893
84MP0001664_abnormal_digestion0.98354576
85MP0001177_atelectasis0.97215545
86MP0003123_paternal_imprinting0.96665364
87MP0002102_abnormal_ear_morphology0.96607159
88MP0005195_abnormal_posterior_eye0.96477445
89MP0008875_abnormal_xenobiotic_pharmacok0.95967848
90MP0002069_abnormal_eating/drinking_beha0.93912321
91MP0000955_abnormal_spinal_cord0.93584895
92MP0004811_abnormal_neuron_physiology0.93495469
93MP0002909_abnormal_adrenal_gland0.92473107
94MP0003252_abnormal_bile_duct0.91942044
95MP0008995_early_reproductive_senescence0.91204945
96MP0002160_abnormal_reproductive_system0.91055889
97MP0009250_abnormal_appendicular_skeleto0.90673681
98MP0003878_abnormal_ear_physiology0.88676378
99MP0005377_hearing/vestibular/ear_phenot0.88676378
100MP0004134_abnormal_chest_morphology0.88277151
101MP0003861_abnormal_nervous_system0.88036193
102MP0001293_anophthalmia0.86022854
103MP0001963_abnormal_hearing_physiology0.84948028
104MP0005551_abnormal_eye_electrophysiolog0.84753143
105MP0000751_myopathy0.84659399
106MP0004215_abnormal_myocardial_fiber0.83103473
107MP0003121_genomic_imprinting0.82452871
108MP0000681_abnormal_thyroid_gland0.79853681
109MP0000569_abnormal_digit_pigmentation0.79831185
110MP0004885_abnormal_endolymph0.79351779
111MP0000538_abnormal_urinary_bladder0.79308535
112MP0003690_abnormal_glial_cell0.79296771
113MP0003136_yellow_coat_color0.78563213
114MP0000647_abnormal_sebaceous_gland0.78065258
115MP0005171_absent_coat_pigmentation0.78050292
116MP0005389_reproductive_system_phenotype0.77581744
117MP0008874_decreased_physiological_sensi0.76449134
118MP0010386_abnormal_urinary_bladder0.76045275
119MP0009697_abnormal_copulation0.75485791
120MP0002277_abnormal_respiratory_mucosa0.74344440
121MP0002332_abnormal_exercise_endurance0.73669602
122MP0003633_abnormal_nervous_system0.73640611
123MP0000026_abnormal_inner_ear0.72755948
124MP0002152_abnormal_brain_morphology0.70465490
125MP0003631_nervous_system_phenotype0.69920905
126MP0001485_abnormal_pinna_reflex0.67106322
127MP0002752_abnormal_somatic_nervous0.66901075
128MP0002229_neurodegeneration0.63321758
129MP0001881_abnormal_mammary_gland0.63320076
130MP0002090_abnormal_vision0.63065719
131MP0004858_abnormal_nervous_system0.62927073
132MP0004883_abnormal_blood_vessel0.61853887
133MP0002638_abnormal_pupillary_reflex0.56736428
134MP0004272_abnormal_basement_membrane0.54691403
135MP0009780_abnormal_chondrocyte_physiolo0.53715610
136MP0004085_abnormal_heartbeat0.53698592
137MP0002254_reproductive_system_inflammat0.51176085
138MP0003632_abnormal_nervous_system0.50490553

Predicted human phenotypes

RankGene SetZ-score
1Limb dystonia (HP:0002451)8.03568147
2Focal motor seizures (HP:0011153)6.39395611
3Myokymia (HP:0002411)4.96421757
4Visual hallucinations (HP:0002367)4.71835765
5Focal seizures (HP:0007359)4.48875819
6True hermaphroditism (HP:0010459)4.42635504
7Pancreatic fibrosis (HP:0100732)4.38272374
8Febrile seizures (HP:0002373)4.19984165
9Pancreatic cysts (HP:0001737)3.98199988
10Absent/shortened dynein arms (HP:0200106)3.86654047
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.86654047
12Abnormal ciliary motility (HP:0012262)3.74815101
13Genetic anticipation (HP:0003743)3.63508015
14Congenital stationary night blindness (HP:0007642)3.57585274
15Failure to thrive in infancy (HP:0001531)3.50336337
16Broad-based gait (HP:0002136)3.40097530
17Epileptic encephalopathy (HP:0200134)3.39896527
18Fetal akinesia sequence (HP:0001989)3.36352056
19Pendular nystagmus (HP:0012043)3.35008566
20Abnormal hair whorl (HP:0010721)3.20874224
21Generalized tonic-clonic seizures (HP:0002069)3.19195243
22Abnormal respiratory motile cilium physiology (HP:0012261)3.12376813
23Oligomenorrhea (HP:0000876)3.05847831
24Absence seizures (HP:0002121)3.04743971
25Abnormal respiratory motile cilium morphology (HP:0005938)3.03946096
26Abnormal respiratory epithelium morphology (HP:0012253)3.03946096
27Hypokinesia (HP:0002375)2.98839542
28Atonic seizures (HP:0010819)2.94850956
29Progressive inability to walk (HP:0002505)2.87432274
30Nephronophthisis (HP:0000090)2.87041630
31Type II lissencephaly (HP:0007260)2.85998160
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.83294664
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.83294664
34Progressive cerebellar ataxia (HP:0002073)2.82201532
35Abnormality of the labia minora (HP:0012880)2.79799966
36Dialeptic seizures (HP:0011146)2.78356245
37Cerebellar dysplasia (HP:0007033)2.72330961
38Hypothermia (HP:0002045)2.71886124
39Cystic liver disease (HP:0006706)2.68347371
40Keratoconus (HP:0000563)2.68118346
41Increased corneal curvature (HP:0100692)2.68118346
42Hyperventilation (HP:0002883)2.66887097
43Gait imbalance (HP:0002141)2.66755349
44Abolished electroretinogram (ERG) (HP:0000550)2.64427685
45Sclerocornea (HP:0000647)2.61761413
46Diminished movement (HP:0002374)2.60491722
47Colon cancer (HP:0003003)2.58990411
48Osteomalacia (HP:0002749)2.57602812
49Fair hair (HP:0002286)2.56439474
50Abnormality of the corticospinal tract (HP:0002492)2.53400616
51Gaze-evoked nystagmus (HP:0000640)2.51811438
52Vaginal atresia (HP:0000148)2.49249125
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.48371849
54Congenital primary aphakia (HP:0007707)2.48083794
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.48044848
56Furrowed tongue (HP:0000221)2.46273606
57Genital tract atresia (HP:0001827)2.45872926
58Blue irides (HP:0000635)2.45828736
59Medial flaring of the eyebrow (HP:0010747)2.44939431
60Anxiety (HP:0000739)2.44380248
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.44315647
62Anencephaly (HP:0002323)2.43793641
63Parakeratosis (HP:0001036)2.40206660
64Sleep apnea (HP:0010535)2.39246752
65Abnormality of the renal medulla (HP:0100957)2.37953553
66Nephrogenic diabetes insipidus (HP:0009806)2.37946765
67Chorioretinal atrophy (HP:0000533)2.33933949
68Large for gestational age (HP:0001520)2.32956411
69Generalized hypopigmentation of hair (HP:0011358)2.32065554
70Concave nail (HP:0001598)2.31429037
71Decreased central vision (HP:0007663)2.30510562
72Abnormal rod and cone electroretinograms (HP:0008323)2.30277952
73Gonadotropin excess (HP:0000837)2.30214912
74Attenuation of retinal blood vessels (HP:0007843)2.30102492
75Abnormality of the renal cortex (HP:0011035)2.30082108
76Torticollis (HP:0000473)2.29283201
77Impaired vibration sensation in the lower limbs (HP:0002166)2.29090526
783-Methylglutaconic aciduria (HP:0003535)2.26180923
79Neuroendocrine neoplasm (HP:0100634)2.26172547
80Pheochromocytoma (HP:0002666)2.25415562
81Short tibia (HP:0005736)2.22098587
82Hemiparesis (HP:0001269)2.21973204
83Polyphagia (HP:0002591)2.21110350
84Male pseudohermaphroditism (HP:0000037)2.20667401
85Renal cortical cysts (HP:0000803)2.20423411
86Agitation (HP:0000713)2.19947055
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19833049
88Abnormality of alanine metabolism (HP:0010916)2.19833049
89Hyperalaninemia (HP:0003348)2.19833049
90Ependymoma (HP:0002888)2.19425747
91Epidermoid cyst (HP:0200040)2.18720847
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.17564065
93Abnormal eating behavior (HP:0100738)2.17547736
94Depression (HP:0000716)2.16694710
95Scanning speech (HP:0002168)2.16241876
96Hypoventilation (HP:0002791)2.14908524
97Lower limb amyotrophy (HP:0007210)2.14908419
98Methylmalonic acidemia (HP:0002912)2.13704168
99Urinary urgency (HP:0000012)2.13258741
100Rhinitis (HP:0012384)2.11308123
101Focal dystonia (HP:0004373)2.09904895
102Absent speech (HP:0001344)2.09442745
103Submucous cleft hard palate (HP:0000176)2.09417718
104Abnormal pupillary function (HP:0007686)2.07051104
105Poor coordination (HP:0002370)2.06967577
106Specific learning disability (HP:0001328)2.06952187
107Mutism (HP:0002300)2.06624854
108Truncal ataxia (HP:0002078)2.06275637
109Brushfield spots (HP:0001088)2.04372090
110Abnormal biliary tract physiology (HP:0012439)2.04003082
111Bile duct proliferation (HP:0001408)2.04003082
112Chronic hepatic failure (HP:0100626)2.02642027
113Partial agenesis of the corpus callosum (HP:0001338)2.02404830
114Acute necrotizing encephalopathy (HP:0006965)1.99845961
115Aplasia involving bones of the upper limbs (HP:0009823)1.97955217
116Aplasia of the phalanges of the hand (HP:0009802)1.97955217
117Aplasia involving bones of the extremities (HP:0009825)1.97955217
118Narrow nasal bridge (HP:0000446)1.97167254
119Aplasia of the musculature (HP:0100854)1.96820158
120Optic nerve hypoplasia (HP:0000609)1.96628569
121Poor suck (HP:0002033)1.96625551
122Lissencephaly (HP:0001339)1.96132536
123Craniofacial dystonia (HP:0012179)1.95101116
124Abnormality of incisor morphology (HP:0011063)1.94671656
125Prolonged QT interval (HP:0001657)1.93034733
126Progressive macrocephaly (HP:0004481)1.91946248
127Drooling (HP:0002307)1.91511187
128Excessive salivation (HP:0003781)1.91511187
129Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.91036775
130Bony spicule pigmentary retinopathy (HP:0007737)1.89444098
131Poor eye contact (HP:0000817)1.89196586
132Potter facies (HP:0002009)1.88811212
133Facial shape deformation (HP:0011334)1.88811212
134Inability to walk (HP:0002540)1.88538516
135Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88062359
136Optic disc pallor (HP:0000543)1.87918183
137Morphological abnormality of the pyramidal tract (HP:0002062)1.87813037
138Increased CSF lactate (HP:0002490)1.86840687
139Postaxial foot polydactyly (HP:0001830)1.85499725
140Pachygyria (HP:0001302)1.84972132
141Congenital hepatic fibrosis (HP:0002612)1.83847186
142Abnormal mitochondria in muscle tissue (HP:0008316)1.83434423
143Bradykinesia (HP:0002067)1.83294729
144Incomplete penetrance (HP:0003829)1.82079856
145Septo-optic dysplasia (HP:0100842)1.80682204
146Mitochondrial inheritance (HP:0001427)1.80560331
147Horizontal nystagmus (HP:0000666)1.80302078
148Molar tooth sign on MRI (HP:0002419)1.79968493
149Abnormality of midbrain morphology (HP:0002418)1.79968493
150Renal Fanconi syndrome (HP:0001994)1.78075066
151Homocystinuria (HP:0002156)1.77797181
152Abnormality of homocysteine metabolism (HP:0010919)1.77797181
153Esotropia (HP:0000565)1.76812801
154Rigidity (HP:0002063)1.76348863
155Fibular aplasia (HP:0002990)1.75664036
156Postaxial hand polydactyly (HP:0001162)1.74243742
157Ankle clonus (HP:0011448)1.73950808
158Distal lower limb muscle weakness (HP:0009053)1.73882537
159Severe muscular hypotonia (HP:0006829)1.72707959
160Abnormal number of erythroid precursors (HP:0012131)1.70927910
161Dysphonia (HP:0001618)1.70656033
162Abnormal EKG (HP:0003115)1.70595194
163Aplasia/Hypoplasia of the spleen (HP:0010451)1.69901468
164Methylmalonic aciduria (HP:0012120)1.69255035
165Small hand (HP:0200055)1.69133313
166Glioma (HP:0009733)1.67068885
167Intestinal atresia (HP:0011100)1.66820429
168Increased hepatocellular lipid droplets (HP:0006565)1.66529340
169Astrocytoma (HP:0009592)1.65925168
170Abnormality of the astrocytes (HP:0100707)1.65925168
171Preaxial hand polydactyly (HP:0001177)1.63932162
172Acute encephalopathy (HP:0006846)1.63634049
173Multicystic kidney dysplasia (HP:0000003)1.63053696
174Adrenal hypoplasia (HP:0000835)1.62292126

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.28350271
2MAP3K123.96875217
3FRK3.90668538
4WNK33.45642392
5CASK3.41450622
6EPHA43.35930682
7MAPKAPK52.60869956
8MAP2K72.59648233
9GRK12.59393127
10SIK32.52836249
11MAP3K92.48937741
12MAP3K132.43043780
13MAP4K22.39613636
14TNIK2.35414029
15MAP3K42.17892002
16MINK12.10921136
17SIK22.02187491
18BMPR1B1.91622607
19MKNK21.86535531
20NTRK21.84475330
21TLK11.80692590
22DYRK21.78086532
23MAP2K41.76075428
24NUAK11.74639454
25PRKD31.74391763
26TAF11.73905867
27BRD41.68999502
28PNCK1.68981669
29GRK51.66221288
30EPHA21.62749981
31BCKDK1.62308866
32RIPK41.61572040
33MARK11.57947298
34PLK21.52422619
35TNK21.52219672
36GRK71.50004914
37ARAF1.47928185
38ACVR1B1.46145685
39BMPR21.32487500
40PRPF4B1.32253852
41CAMK2A1.32114740
42CAMK2B1.27271293
43NTRK11.24750559
44CAMKK21.24607949
45CDK51.22431311
46FGFR21.21939245
47PRKCG1.20211667
48NEK61.16399653
49CSNK1A1L1.15539473
50MKNK11.15007522
51FES1.14508269
52TYRO31.13400114
53LATS21.10152800
54WNK41.08039517
55MAPK131.06576670
56SGK21.06548336
57CAMK2D1.06422815
58VRK11.03504809
59TAOK30.99830258
60CAMK2G0.98059019
61VRK20.90350701
62UHMK10.89858967
63SGK2230.89580247
64SGK4940.89580247
65FER0.86184529
66CAMKK10.83466278
67EPHB20.81375401
68TGFBR10.80383072
69OXSR10.79738355
70STK380.77838885
71FGR0.76988096
72AKT30.76954933
73CAMK10.76921246
74PAK30.76133718
75PRKCE0.75728564
76CDK180.75579973
77PAK60.74306973
78SGK10.74121614
79MUSK0.73652095
80TSSK60.72214375
81ZAK0.71826194
82LMTK20.71646057
83DYRK30.71424727
84CSNK1G20.71099315
85ADRBK10.69646283
86KSR10.69534270
87INSRR0.68872536
88CDK150.68668207
89BCR0.68081514
90PRKCI0.67972930
91TRIM280.67893090
92SGK30.67598547
93CDK140.67132856
94CDK190.67100298
95ERBB30.65285433
96* ADRBK20.63872861
97PRKCH0.62492119
98PRKCZ0.59651499
99CSNK1G30.59583498
100STK160.58263479
101KSR20.58196284
102CDK11A0.56326410
103MAP2K10.56103819
104STK390.55104981
105PLK30.54983767
106PBK0.54971962
107TXK0.54911968
108PINK10.54868236
109PHKG10.54537968
110PHKG20.54537968
111TAOK10.53790545
112NME10.53248893
113STK110.52868277
114MAP3K10.52791458
115LATS10.52658498
116PTK2B0.52395967
117MAPK150.52099366
118CDC42BPA0.51653595
119DYRK1A0.50885039
120YES10.50182975
121CSNK1A10.49222756
122CAMK1D0.49118615
123ERBB20.48416457
124DAPK20.47164414
125OBSCN0.46126952
126PLK40.45596348
127BRSK20.45497313
128PRKD20.45285241
129BRAF0.43686053
130PRKACA0.42932848
131NEK20.42043079
132WNK10.42021331
133CAMK40.38777169
134CSNK1D0.37353754
135MAP3K140.37027972
136PRKCA0.36609166
137MYLK0.36433404
138PRKAA10.36378417
139PRKCB0.36010356
140PKN10.35519942
141MARK20.35085871
142CSNK1G10.34104165
143CAMK1G0.33958520
144EPHA30.33296724
145MAP2K60.32098401
146STK38L0.31946664

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.56483896
2Synaptic vesicle cycle_Homo sapiens_hsa047213.50540673
3Cocaine addiction_Homo sapiens_hsa050303.08226226
4Amphetamine addiction_Homo sapiens_hsa050312.85510775
5Morphine addiction_Homo sapiens_hsa050322.79538722
6GABAergic synapse_Homo sapiens_hsa047272.78686969
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78080129
8Olfactory transduction_Homo sapiens_hsa047402.68258791
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.67198607
10Collecting duct acid secretion_Homo sapiens_hsa049662.63458176
11Oxidative phosphorylation_Homo sapiens_hsa001902.40147352
12Circadian entrainment_Homo sapiens_hsa047132.26610475
13Dopaminergic synapse_Homo sapiens_hsa047282.24764960
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24211513
15Parkinsons disease_Homo sapiens_hsa050122.22894386
16Taste transduction_Homo sapiens_hsa047422.21166120
17Glutamatergic synapse_Homo sapiens_hsa047242.18219804
18* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.17077412
19Selenocompound metabolism_Homo sapiens_hsa004502.16186941
20Serotonergic synapse_Homo sapiens_hsa047262.09432112
21Hedgehog signaling pathway_Homo sapiens_hsa043402.02316114
22Basal cell carcinoma_Homo sapiens_hsa052171.83139792
23Long-term potentiation_Homo sapiens_hsa047201.82061228
24Linoleic acid metabolism_Homo sapiens_hsa005911.81517691
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.81458763
26Cholinergic synapse_Homo sapiens_hsa047251.78388926
27Protein export_Homo sapiens_hsa030601.77161358
28Salivary secretion_Homo sapiens_hsa049701.71398809
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68376882
30Tryptophan metabolism_Homo sapiens_hsa003801.68261824
31Calcium signaling pathway_Homo sapiens_hsa040201.63700582
32Alzheimers disease_Homo sapiens_hsa050101.61779012
33Nitrogen metabolism_Homo sapiens_hsa009101.60771910
34Vibrio cholerae infection_Homo sapiens_hsa051101.57398390
35Renin secretion_Homo sapiens_hsa049241.56748800
36Cardiac muscle contraction_Homo sapiens_hsa042601.52262216
37Long-term depression_Homo sapiens_hsa047301.50911212
38Gastric acid secretion_Homo sapiens_hsa049711.44319043
39Steroid biosynthesis_Homo sapiens_hsa001001.44216492
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.44043082
41Insulin secretion_Homo sapiens_hsa049111.43850739
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.33678097
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31730822
44Huntingtons disease_Homo sapiens_hsa050161.25525091
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23232247
46Oxytocin signaling pathway_Homo sapiens_hsa049211.21360460
47RNA polymerase_Homo sapiens_hsa030201.21137150
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20709256
49Peroxisome_Homo sapiens_hsa041461.17510005
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15814078
51Phototransduction_Homo sapiens_hsa047441.13544566
52Basal transcription factors_Homo sapiens_hsa030221.12162516
53Propanoate metabolism_Homo sapiens_hsa006401.10744523
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10400100
55Sulfur metabolism_Homo sapiens_hsa009201.09360393
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08702996
57Caffeine metabolism_Homo sapiens_hsa002321.07123421
58Rheumatoid arthritis_Homo sapiens_hsa053231.06844214
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06808192
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04740962
61Gap junction_Homo sapiens_hsa045401.04358346
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02866906
63Circadian rhythm_Homo sapiens_hsa047100.99037785
64Axon guidance_Homo sapiens_hsa043600.98150101
65RNA degradation_Homo sapiens_hsa030180.97606120
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92360529
67Vitamin digestion and absorption_Homo sapiens_hsa049770.91705104
68African trypanosomiasis_Homo sapiens_hsa051430.91101258
69GnRH signaling pathway_Homo sapiens_hsa049120.87089383
70cAMP signaling pathway_Homo sapiens_hsa040240.84743176
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83948797
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83048176
73Homologous recombination_Homo sapiens_hsa034400.79195886
74Melanogenesis_Homo sapiens_hsa049160.79113858
75Fanconi anemia pathway_Homo sapiens_hsa034600.76295379
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.71494347
77Estrogen signaling pathway_Homo sapiens_hsa049150.71259533
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71203145
79Tyrosine metabolism_Homo sapiens_hsa003500.70624289
80Type I diabetes mellitus_Homo sapiens_hsa049400.70147725
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.69643654
82Histidine metabolism_Homo sapiens_hsa003400.69556789
83Butanoate metabolism_Homo sapiens_hsa006500.69184260
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68413418
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67428654
86Regulation of autophagy_Homo sapiens_hsa041400.66934979
87Alcoholism_Homo sapiens_hsa050340.65741665
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65427679
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65203966
90Dorso-ventral axis formation_Homo sapiens_hsa043200.63466884
91Glycerolipid metabolism_Homo sapiens_hsa005610.61937162
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60419821
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60065505
94Dilated cardiomyopathy_Homo sapiens_hsa054140.59871820
95ErbB signaling pathway_Homo sapiens_hsa040120.59821850
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58682694
97Type II diabetes mellitus_Homo sapiens_hsa049300.58189437
98Metabolic pathways_Homo sapiens_hsa011000.56086308
99Hippo signaling pathway_Homo sapiens_hsa043900.55406157
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54740329
101Phagosome_Homo sapiens_hsa041450.54629606
102One carbon pool by folate_Homo sapiens_hsa006700.53697005
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53027158
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52390307
105Pancreatic secretion_Homo sapiens_hsa049720.50935466
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50147307
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.50028229
108Chemical carcinogenesis_Homo sapiens_hsa052040.49891321
109Ribosome_Homo sapiens_hsa030100.49402826
110Thyroid hormone synthesis_Homo sapiens_hsa049180.48761255
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47947129
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46465119
113Prion diseases_Homo sapiens_hsa050200.44067014
114Arachidonic acid metabolism_Homo sapiens_hsa005900.43077659
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42816122
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40777687
117Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.40333791
118ABC transporters_Homo sapiens_hsa020100.39536766
119Purine metabolism_Homo sapiens_hsa002300.39520881
120Phenylalanine metabolism_Homo sapiens_hsa003600.38504521
121Ovarian steroidogenesis_Homo sapiens_hsa049130.37970723
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37748069
123beta-Alanine metabolism_Homo sapiens_hsa004100.37502345
124MAPK signaling pathway_Homo sapiens_hsa040100.36561079
125Retinol metabolism_Homo sapiens_hsa008300.36184115
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.35305246
127Ras signaling pathway_Homo sapiens_hsa040140.34900594
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34174760
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33953152
130Melanoma_Homo sapiens_hsa052180.33516776
131Starch and sucrose metabolism_Homo sapiens_hsa005000.30294783
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29235299
133Mineral absorption_Homo sapiens_hsa049780.28116507
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27226271
135Rap1 signaling pathway_Homo sapiens_hsa040150.26936431
136Wnt signaling pathway_Homo sapiens_hsa043100.26319913
137Prolactin signaling pathway_Homo sapiens_hsa049170.26040109
138Glioma_Homo sapiens_hsa052140.25176158
139Choline metabolism in cancer_Homo sapiens_hsa052310.21343834
140Sphingolipid metabolism_Homo sapiens_hsa006000.21235617
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.19522215
142Inositol phosphate metabolism_Homo sapiens_hsa005620.18988541
143Autoimmune thyroid disease_Homo sapiens_hsa053200.18843259
144Chemokine signaling pathway_Homo sapiens_hsa040620.18196272
145Ether lipid metabolism_Homo sapiens_hsa005650.17437211

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