OPRM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.46323564
2detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.64541970
3adult feeding behavior (GO:0008343)4.56852194
4ether lipid metabolic process (GO:0046485)4.53482934
5regulation of acrosome reaction (GO:0060046)4.52603300
6detection of temperature stimulus (GO:0016048)4.43624035
7detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.42517382
8detection of temperature stimulus involved in sensory perception (GO:0050961)4.42517382
9regulation of protein glycosylation (GO:0060049)4.36672185
10indolalkylamine metabolic process (GO:0006586)4.31187444
11negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.26004492
12regulation of activation of Janus kinase activity (GO:0010533)4.19199913
13peripheral nervous system neuron development (GO:0048935)4.17174434
14negative regulation of dendrite morphogenesis (GO:0050774)4.11531930
15regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.07553370
16indole-containing compound catabolic process (GO:0042436)4.03654935
17indolalkylamine catabolic process (GO:0046218)4.03654935
18tryptophan catabolic process (GO:0006569)4.03654935
19sphingoid metabolic process (GO:0046519)3.98912420
20cellular ketone body metabolic process (GO:0046950)3.91810316
21kynurenine metabolic process (GO:0070189)3.85957088
22phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.81980649
23detection of light stimulus involved in sensory perception (GO:0050962)3.80112086
24detection of light stimulus involved in visual perception (GO:0050908)3.80112086
25response to pheromone (GO:0019236)3.78108211
26sphingosine metabolic process (GO:0006670)3.76310366
27diol metabolic process (GO:0034311)3.56997887
28neuron cell-cell adhesion (GO:0007158)3.55294686
29ketone body metabolic process (GO:1902224)3.54670437
30tryptophan metabolic process (GO:0006568)3.52912891
31photoreceptor cell maintenance (GO:0045494)3.52112395
32DNA deamination (GO:0045006)3.42198152
33indole-containing compound metabolic process (GO:0042430)3.35336456
34regulation of short-term neuronal synaptic plasticity (GO:0048172)3.33500067
35neural tube formation (GO:0001841)3.33039293
36adenosine metabolic process (GO:0046085)3.31801186
37neuronal action potential (GO:0019228)3.26287498
38negative regulation of dendrite development (GO:2000171)3.24806260
39cornea development in camera-type eye (GO:0061303)3.23416122
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19867552
41cilium or flagellum-dependent cell motility (GO:0001539)3.19654081
42* regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19346952
43membrane depolarization during action potential (GO:0086010)3.18355629
44negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.16935931
45thyroid hormone metabolic process (GO:0042403)3.14906664
46dopamine transport (GO:0015872)3.14040118
47multicellular organism reproduction (GO:0032504)3.10584231
48positive regulation of fatty acid transport (GO:2000193)3.10558994
49neurotransmitter-gated ion channel clustering (GO:0072578)3.09389443
50pyrimidine dimer repair (GO:0006290)3.08377406
51phosphatidylinositol acyl-chain remodeling (GO:0036149)3.07983248
52DNA methylation involved in gamete generation (GO:0043046)3.07528340
53superoxide anion generation (GO:0042554)3.07443843
54regulation of rhodopsin mediated signaling pathway (GO:0022400)3.06631621
55* negative regulation of cytosolic calcium ion concentration (GO:0051481)3.06058009
56positive regulation of alpha-beta T cell proliferation (GO:0046641)3.05528808
57presynaptic membrane assembly (GO:0097105)3.05333779
58replication fork processing (GO:0031297)3.03508826
59negative regulation of calcium ion transport into cytosol (GO:0010523)3.02851691
60protein K11-linked deubiquitination (GO:0035871)3.01808107
61cellular response to exogenous dsRNA (GO:0071360)3.01556213
62positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.01040803
63vocalization behavior (GO:0071625)3.00750974
64regulation of synaptic vesicle exocytosis (GO:2000300)2.99695379
65rhodopsin mediated signaling pathway (GO:0016056)2.99179861
66postsynaptic membrane organization (GO:0001941)2.98561884
67regulation of synaptic transmission, glutamatergic (GO:0051966)2.98010097
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96973810
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96457082
70synaptic vesicle exocytosis (GO:0016079)2.95485068
71behavioral response to nicotine (GO:0035095)2.95388277
72synaptic vesicle docking involved in exocytosis (GO:0016081)2.94108210
73regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.94058088
74cellular response to ATP (GO:0071318)2.93628764
75regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.93231193
76regulation of T-helper 1 cell differentiation (GO:0045625)2.92409381
77serotonin metabolic process (GO:0042428)2.92383090
78glycerophospholipid catabolic process (GO:0046475)2.91424712
79behavioral response to pain (GO:0048266)2.88785385
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.88780609
81cAMP catabolic process (GO:0006198)2.88126718
82ionotropic glutamate receptor signaling pathway (GO:0035235)2.87938246
83regulation of glutamate secretion (GO:0014048)2.87924024
84sulfation (GO:0051923)2.87343554
85RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.87129565
86regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.86976761
87positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.86976761
88glutamate receptor signaling pathway (GO:0007215)2.86883198
89epithelial cilium movement (GO:0003351)2.86519819
90negative regulation of mast cell activation (GO:0033004)2.84487845
91primary amino compound metabolic process (GO:1901160)2.84465777
92cellular response to nicotine (GO:0071316)2.83620511
93regulation of translational termination (GO:0006449)2.82626062
94positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.82566584
95retinal cone cell development (GO:0046549)2.82276503
96natural killer cell activation involved in immune response (GO:0002323)2.82229838
97gamma-aminobutyric acid transport (GO:0015812)2.81776036
98preassembly of GPI anchor in ER membrane (GO:0016254)2.80358594
99respiratory burst (GO:0045730)2.79983671
100negative regulation of amino acid transport (GO:0051956)2.78187969
101signal peptide processing (GO:0006465)2.77774601
102thrombin receptor signaling pathway (GO:0070493)2.77695759
103reflex (GO:0060004)2.77462042
104neuronal action potential propagation (GO:0019227)2.75704198
105cellular biogenic amine catabolic process (GO:0042402)2.75189971
106amine catabolic process (GO:0009310)2.75189971
107L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73784728
108potassium ion export (GO:0071435)2.73297949
109sperm motility (GO:0030317)2.73214314
110cilium morphogenesis (GO:0060271)2.72890443
111long-chain fatty acid biosynthetic process (GO:0042759)2.72317457
112thyroid hormone generation (GO:0006590)2.70646965
113membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70152775
114regulation of memory T cell differentiation (GO:0043380)2.69191044
115presynaptic membrane organization (GO:0097090)2.68201952
116proline transport (GO:0015824)2.68136674
117platelet dense granule organization (GO:0060155)2.67751027
118response to pain (GO:0048265)2.67559442
119* regulation of glutamate receptor signaling pathway (GO:1900449)2.67291758
120regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.66963067
121positive regulation of T-helper cell differentiation (GO:0045624)2.66778680
122interferon-gamma production (GO:0032609)2.65868918
123axoneme assembly (GO:0035082)2.65324633
124positive regulation of synaptic transmission, GABAergic (GO:0032230)2.65220447
125transmission of nerve impulse (GO:0019226)2.65066420
126positive regulation of icosanoid secretion (GO:0032305)2.64636388
127negative regulation of homotypic cell-cell adhesion (GO:0034111)2.63864108
128protein localization to synapse (GO:0035418)2.63179323
129regulation of synaptic vesicle transport (GO:1902803)2.62103854
130auditory receptor cell stereocilium organization (GO:0060088)2.59390868
131cellular response to interleukin-15 (GO:0071350)2.59202695
132regulation of female receptivity (GO:0045924)2.58742415
133cyclic nucleotide catabolic process (GO:0009214)2.57974925
134* sensory perception of pain (GO:0019233)2.56852692
135regulation of cilium movement (GO:0003352)2.56480093
136detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.56366422
137response to peptidoglycan (GO:0032494)2.55877028
138negative regulation of type 2 immune response (GO:0002829)2.55685561
139benzene-containing compound metabolic process (GO:0042537)2.54514409
140regulation of platelet aggregation (GO:0090330)2.53398420
141tachykinin receptor signaling pathway (GO:0007217)2.52352801
142photoreceptor cell development (GO:0042461)2.51856162
143phagosome maturation (GO:0090382)2.49821985
144positive regulation of cellular amide metabolic process (GO:0034250)2.49596960
145phosphorelay signal transduction system (GO:0000160)2.49322996
146glycerol ether metabolic process (GO:0006662)2.48998877
147regulation of neurotransmitter secretion (GO:0046928)2.48997990
148regulation of meiosis I (GO:0060631)2.48914864
149positive regulation of defense response to virus by host (GO:0002230)2.48555203
150regulation of nuclear cell cycle DNA replication (GO:0033262)2.48359988
151nucleotide transmembrane transport (GO:1901679)2.47727973
152dendritic cell chemotaxis (GO:0002407)2.47316184
153glycosphingolipid biosynthetic process (GO:0006688)2.47128206
154neuromuscular synaptic transmission (GO:0007274)2.47119534
155regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.46384431
156positive regulation of T-helper 1 type immune response (GO:0002827)2.46355480
157regulation of hippo signaling (GO:0035330)2.45940292
158adaptation of signaling pathway (GO:0023058)2.45923759
159startle response (GO:0001964)2.45346205
160embryonic epithelial tube formation (GO:0001838)2.44520393
161regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.44470157
162membrane depolarization (GO:0051899)2.44317805
163detection of mechanical stimulus involved in sensory perception (GO:0050974)2.43158754
164negative regulation of smooth muscle contraction (GO:0045986)2.43137491
165inner ear receptor stereocilium organization (GO:0060122)2.42671203
166detection of mechanical stimulus (GO:0050982)2.42661870
167negative regulation of systemic arterial blood pressure (GO:0003085)2.42152837
168synaptic transmission, glutamatergic (GO:0035249)2.41858734
169regulation of action potential (GO:0098900)2.41290527
170* dopamine receptor signaling pathway (GO:0007212)2.41214067
171production of molecular mediator involved in inflammatory response (GO:0002532)2.39174742
172neuron-neuron synaptic transmission (GO:0007270)2.38900253
173negative regulation of T cell mediated immunity (GO:0002710)2.38457036
174positive regulation of interleukin-17 production (GO:0032740)2.38310929
175positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.38118971
176regulation of inositol phosphate biosynthetic process (GO:0010919)2.36116103
177action potential (GO:0001508)2.34559028
178cellular response to pH (GO:0071467)2.34528508
179L-fucose catabolic process (GO:0042355)2.34208752
180fucose catabolic process (GO:0019317)2.34208752
181L-fucose metabolic process (GO:0042354)2.34208752
182detection of calcium ion (GO:0005513)2.33928579
183regulation of vesicle fusion (GO:0031338)2.32917053
184positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.32907511
185regulation of alpha-beta T cell proliferation (GO:0046640)2.32661899
186activation of adenylate cyclase activity (GO:0007190)2.32246346

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.24718918
2GBX2_23144817_ChIP-Seq_PC3_Human4.20635155
3ZNF274_21170338_ChIP-Seq_K562_Hela3.38662783
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73005772
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65443820
6TAF15_26573619_Chip-Seq_HEK293_Human2.52589883
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46734781
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41302417
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.33786480
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24793148
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16980719
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15648427
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13977615
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13029894
15IGF1R_20145208_ChIP-Seq_DFB_Human2.09355734
16REST_21632747_ChIP-Seq_MESCs_Mouse2.09016771
17P300_19829295_ChIP-Seq_ESCs_Human2.08904485
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03966878
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.03718896
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03191144
21VDR_22108803_ChIP-Seq_LS180_Human2.01171130
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.00258954
23SMAD4_21799915_ChIP-Seq_A2780_Human1.97505495
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93616693
25* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88602035
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86240170
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84761820
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79067774
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79067774
30* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78810593
31BCAT_22108803_ChIP-Seq_LS180_Human1.78124305
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.74281778
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.73206636
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72990335
35CBP_20019798_ChIP-Seq_JUKART_Human1.71416196
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71416196
37EWS_26573619_Chip-Seq_HEK293_Human1.69396555
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67940434
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65713055
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64809445
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61130914
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.59719806
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.58449179
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.57623888
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.57406170
46* RNF2_27304074_Chip-Seq_NSC_Mouse1.56149804
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55962175
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.55139293
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54834237
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54716418
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53453759
52IRF8_21731497_ChIP-ChIP_J774_Mouse1.52961031
53* NANOG_19829295_ChIP-Seq_ESCs_Human1.50194526
54* SOX2_19829295_ChIP-Seq_ESCs_Human1.50194526
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49767376
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48975851
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.48895280
58E2F1_18555785_Chip-Seq_ESCs_Mouse1.47169288
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46568373
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46100160
61IRF1_19129219_ChIP-ChIP_H3396_Human1.45760561
62P53_22387025_ChIP-Seq_ESCs_Mouse1.45338682
63AR_25329375_ChIP-Seq_VCAP_Human1.43563484
64SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41911470
65TP53_22573176_ChIP-Seq_HFKS_Human1.41116390
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.41111012
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.40691426
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.40497418
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39695600
70IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39522181
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39294693
72* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37083838
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.35466244
74* REST_18959480_ChIP-ChIP_MESCs_Mouse1.35457648
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34304300
76DROSHA_22980978_ChIP-Seq_HELA_Human1.34026556
77TP53_18474530_ChIP-ChIP_U2OS_Human1.33326078
78* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33265905
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.33103700
80* EZH2_27294783_Chip-Seq_NPCs_Mouse1.33045985
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32740816
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31304269
83* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30780493
84NMYC_18555785_Chip-Seq_ESCs_Mouse1.30599671
85TCF4_22108803_ChIP-Seq_LS180_Human1.30519205
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29703921
87FUS_26573619_Chip-Seq_HEK293_Human1.28495553
88* KDM2B_26808549_Chip-Seq_REH_Human1.28392185
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.28342717
90RXR_22108803_ChIP-Seq_LS180_Human1.27528168
91AR_21572438_ChIP-Seq_LNCaP_Human1.27379240
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26914169
93RUNX1_27457419_Chip-Seq_LIVER_Mouse1.25812612
94* FLI1_21867929_ChIP-Seq_TH2_Mouse1.25691931
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.25170021
96PU1_27457419_Chip-Seq_LIVER_Mouse1.24658694
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24644738
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24449822
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24253945
100CDX2_22108803_ChIP-Seq_LS180_Human1.23759214
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.22405881
102* STAT3_23295773_ChIP-Seq_U87_Human1.22139285
103JUN_21703547_ChIP-Seq_K562_Human1.22024974
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21850345
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21712457
106SOX2_18555785_Chip-Seq_ESCs_Mouse1.20907370
107ER_23166858_ChIP-Seq_MCF-7_Human1.20627158
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20440085
109P300_18555785_Chip-Seq_ESCs_Mouse1.20355934
110P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20076250
111TCF4_23295773_ChIP-Seq_U87_Human1.18839278
112GATA3_21878914_ChIP-Seq_MCF-7_Human1.18776475
113NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17518174
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16289014
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15660709
116* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15178268
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14968718
118FOXA1_25329375_ChIP-Seq_VCAP_Human1.14968718
119* CRX_20693478_ChIP-Seq_RETINA_Mouse1.14815030
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14664340
121OCT4_18555785_Chip-Seq_ESCs_Mouse1.14221523
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14161285
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.13218258
124CTCF_18555785_Chip-Seq_ESCs_Mouse1.13187671
125IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12384295
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11965733
127* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11606362
128* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11606362
129CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10501120
130EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09429378
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08681732
132ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08488391
133SOX2_21211035_ChIP-Seq_LN229_Gbm1.08424943
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08391597
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07916001
136* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07365162
137PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07026620
138GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05789401
139KLF4_18555785_Chip-Seq_ESCs_Mouse1.05026699
140* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04764546
141HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02577180
142TP53_16413492_ChIP-PET_HCT116_Human1.02461091
143* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02196005
144KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01620480
145AR_20517297_ChIP-Seq_VCAP_Human1.01111661
146* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00559085
147ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00553984
148NCOR_22424771_ChIP-Seq_293T_Human0.99286550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001968_abnormal_touch/_nociception4.40983348
2MP0002735_abnormal_chemical_nociception4.30447939
3MP0002736_abnormal_nociception_after4.11145634
4MP0001986_abnormal_taste_sensitivity3.64657649
5MP0006276_abnormal_autonomic_nervous3.59049068
6MP0003880_abnormal_central_pattern3.33182195
7MP0000569_abnormal_digit_pigmentation3.14331279
8MP0003195_calcinosis2.98739881
9MP0005551_abnormal_eye_electrophysiolog2.93682858
10MP0004270_analgesia2.83721780
11* MP0002733_abnormal_thermal_nociception2.70373055
12MP0002734_abnormal_mechanical_nocicepti2.66618184
13MP0010386_abnormal_urinary_bladder2.62764557
14MP0003646_muscle_fatigue2.60473056
15MP0001188_hyperpigmentation2.49323148
16MP0002876_abnormal_thyroid_physiology2.49281308
17MP0008877_abnormal_DNA_methylation2.49095213
18* MP0001970_abnormal_pain_threshold2.47627335
19MP0009780_abnormal_chondrocyte_physiolo2.45632368
20* MP0009745_abnormal_behavioral_response2.42584610
21MP0004859_abnormal_synaptic_plasticity2.41106130
22MP0009046_muscle_twitch2.32706818
23* MP0003635_abnormal_synaptic_transmissio2.31612319
24MP0005423_abnormal_somatic_nervous2.21846961
25MP0005360_urolithiasis2.17117105
26MP0005645_abnormal_hypothalamus_physiol2.11892017
27* MP0002272_abnormal_nervous_system2.10885033
28MP0002064_seizures2.09259251
29MP0002148_abnormal_hypersensitivity_rea2.03778248
30MP0002102_abnormal_ear_morphology1.98073562
31MP0008872_abnormal_physiological_respon1.92503989
32MP0004043_abnormal_pH_regulation1.90068584
33* MP0002063_abnormal_learning/memory/cond1.87854652
34MP0002163_abnormal_gland_morphology1.87688874
35MP0003183_abnormal_peptide_metabolism1.87671205
36* MP0002572_abnormal_emotion/affect_behav1.87407872
37* MP0002067_abnormal_sensory_capabilities1.87250686
38MP0002837_dystrophic_cardiac_calcinosis1.83246395
39MP0008875_abnormal_xenobiotic_pharmacok1.79579392
40MP0005646_abnormal_pituitary_gland1.78473177
41MP0002184_abnormal_innervation1.71994609
42MP0001486_abnormal_startle_reflex1.69134618
43MP0002638_abnormal_pupillary_reflex1.67661138
44MP0008057_abnormal_DNA_replication1.67565077
45MP0005409_darkened_coat_color1.63109628
46MP0002822_catalepsy1.59240165
47MP0003724_increased_susceptibility_to1.57073323
48MP0009785_altered_susceptibility_to1.56843670
49MP0000427_abnormal_hair_cycle1.55754268
50MP0001835_abnormal_antigen_presentation1.53800634
51MP0004742_abnormal_vestibular_system1.52609217
52MP0001485_abnormal_pinna_reflex1.52338845
53MP0005379_endocrine/exocrine_gland_phen1.52259189
54MP0003136_yellow_coat_color1.51546266
55MP0000372_irregular_coat_pigmentation1.49311393
56MP0001984_abnormal_olfaction1.49310476
57MP0005253_abnormal_eye_physiology1.49014122
58MP0001501_abnormal_sleep_pattern1.43754320
59MP0004142_abnormal_muscle_tone1.43731750
60MP0005167_abnormal_blood-brain_barrier1.42904343
61MP0001764_abnormal_homeostasis1.41153459
62MP0003879_abnormal_hair_cell1.39501185
63MP0006082_CNS_inflammation1.38863888
64MP0003950_abnormal_plasma_membrane1.36584955
65MP0003787_abnormal_imprinting1.33761587
66MP0006072_abnormal_retinal_apoptosis1.33426796
67MP0003045_fibrosis1.32778694
68MP0001440_abnormal_grooming_behavior1.28103664
69MP0004885_abnormal_endolymph1.25468487
70MP0005503_abnormal_tendon_morphology1.24377978
71MP0006035_abnormal_mitochondrial_morpho1.24077702
72* MP0002557_abnormal_social/conspecific_i1.22485431
73MP0005671_abnormal_response_to1.21636933
74MP0000230_abnormal_systemic_arterial1.21260105
75MP0005670_abnormal_white_adipose1.21014103
76MP0004858_abnormal_nervous_system1.20476158
77MP0003122_maternal_imprinting1.19232604
78MP0002138_abnormal_hepatobiliary_system1.18567651
79MP0003436_decreased_susceptibility_to1.17688209
80MP0005389_reproductive_system_phenotype1.17587549
81MP0005000_abnormal_immune_tolerance1.17447316
82MP0004147_increased_porphyrin_level1.17017326
83MP0008004_abnormal_stomach_pH1.13317130
84MP0001905_abnormal_dopamine_level1.13092859
85MP0002751_abnormal_autonomic_nervous1.12760570
86MP0008775_abnormal_heart_ventricle1.11946887
87MP0000015_abnormal_ear_pigmentation1.10819035
88MP0005085_abnormal_gallbladder_physiolo1.10578263
89MP0005195_abnormal_posterior_eye1.08725640
90MP0001348_abnormal_lacrimal_gland1.05337791
91MP0002095_abnormal_skin_pigmentation1.05058207
92MP0005386_behavior/neurological_phenoty1.04980860
93MP0004924_abnormal_behavior1.04980860
94MP0001529_abnormal_vocalization1.04693755
95MP0002229_neurodegeneration1.03348707
96MP0002419_abnormal_innate_immunity1.01835563
97MP0002928_abnormal_bile_duct1.01453461
98MP0004510_myositis1.00126119
99MP0001790_abnormal_immune_system1.00109204
100MP0005387_immune_system_phenotype1.00109204
101MP0002160_abnormal_reproductive_system0.99283757
102MP0002277_abnormal_respiratory_mucosa0.97799709
103MP0000681_abnormal_thyroid_gland0.96597195
104MP0005410_abnormal_fertilization0.95509238
105MP0009697_abnormal_copulation0.94844669
106MP0009379_abnormal_foot_pigmentation0.93884234
107MP0000631_abnormal_neuroendocrine_gland0.93867926
108MP0001963_abnormal_hearing_physiology0.93542956
109MP0004811_abnormal_neuron_physiology0.92593531
110MP0005025_abnormal_response_to0.92535039
111MP0005535_abnormal_body_temperature0.91920675
112MP0001324_abnormal_eye_pigmentation0.90776960
113MP0001919_abnormal_reproductive_system0.89541815
114MP0001502_abnormal_circadian_rhythm0.89418259
115MP0005174_abnormal_tail_pigmentation0.89384299
116MP0000383_abnormal_hair_follicle0.87275564
117MP0003638_abnormal_response/metabolism_0.85180825
118MP0008260_abnormal_autophagy0.85082818
119MP0003172_abnormal_lysosome_physiology0.85002779
120MP0003252_abnormal_bile_duct0.84037972
121MP0000955_abnormal_spinal_cord0.83112769
122MP0002752_abnormal_somatic_nervous0.82326136
123MP0000778_abnormal_nervous_system0.82059879
124* MP0008874_decreased_physiological_sensi0.81984898
125MP0004145_abnormal_muscle_electrophysio0.81461108
126MP0005171_absent_coat_pigmentation0.80706567
127MP0002723_abnormal_immune_serum0.79876447
128* MP0002066_abnormal_motor_capabilities/c0.79678988
129MP0005310_abnormal_salivary_gland0.78696097
130* MP0003698_abnormal_male_reproductive0.78567831
131MP0003941_abnormal_skin_development0.78040950
132MP0002882_abnormal_neuron_morphology0.77412490
133MP0001756_abnormal_urination0.77207562
134MP0002909_abnormal_adrenal_gland0.77095730
135* MP0002693_abnormal_pancreas_physiology0.76699859
136MP0000538_abnormal_urinary_bladder0.76409095
137MP0004130_abnormal_muscle_cell0.76293098
138MP0001800_abnormal_humoral_immune0.72007892
139MP0004215_abnormal_myocardial_fiber0.70503812
140* MP0001664_abnormal_digestion0.68768407
141MP0003718_maternal_effect0.67959266
142MP0003828_pulmonary_edema0.67743942
143* MP0003633_abnormal_nervous_system0.66945708
144MP0006292_abnormal_olfactory_placode0.63860774
145MP0002452_abnormal_antigen_presenting0.63483460
146MP0001819_abnormal_immune_cell0.62479786
147MP0008569_lethality_at_weaning0.61796169
148MP0002420_abnormal_adaptive_immunity0.61571885
149MP0004085_abnormal_heartbeat0.59651003
150MP0005464_abnormal_platelet_physiology0.59047111
151* MP0009764_decreased_sensitivity_to0.58702789
152MP0000026_abnormal_inner_ear0.58564656
153MP0001346_abnormal_lacrimal_gland0.56830223

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.20758353
2Thyroid-stimulating hormone excess (HP:0002925)6.17840512
3Hypothermia (HP:0002045)4.69746929
4Focal seizures (HP:0007359)4.58150713
5Febrile seizures (HP:0002373)4.25741192
6Congenital stationary night blindness (HP:0007642)4.10616333
7Visual hallucinations (HP:0002367)4.02368005
8Type II lissencephaly (HP:0007260)3.87297684
9Volvulus (HP:0002580)3.86981614
10Abnormal hair whorl (HP:0010721)3.85015734
11Gaze-evoked nystagmus (HP:0000640)3.80034463
12Pancreatic cysts (HP:0001737)3.80002105
13Epileptic encephalopathy (HP:0200134)3.65001422
14Attenuation of retinal blood vessels (HP:0007843)3.54612445
15Intestinal atresia (HP:0011100)3.52053427
16Dialeptic seizures (HP:0011146)3.47285194
17Atonic seizures (HP:0010819)3.30599294
18Abolished electroretinogram (ERG) (HP:0000550)3.26329014
19Progressive cerebellar ataxia (HP:0002073)3.23132665
20Increased IgM level (HP:0003496)3.19536098
21Cerebellar dysplasia (HP:0007033)3.18608002
22Tubular atrophy (HP:0000092)3.18001840
23Myokymia (HP:0002411)3.16624500
24Large for gestational age (HP:0001520)3.15501989
25Pendular nystagmus (HP:0012043)3.14979318
26Keratoconus (HP:0000563)3.11037829
27Increased corneal curvature (HP:0100692)3.11037829
28Abnormality of the renal cortex (HP:0011035)2.94643837
29Nephronophthisis (HP:0000090)2.94035605
30Hyperventilation (HP:0002883)2.91540914
31Absence seizures (HP:0002121)2.87971100
32Eczematoid dermatitis (HP:0000976)2.82170683
33Generalized tonic-clonic seizures (HP:0002069)2.80151409
34Agitation (HP:0000713)2.78287375
35Abnormality of the renal medulla (HP:0100957)2.73336483
36Bony spicule pigmentary retinopathy (HP:0007737)2.70187709
37Anhidrosis (HP:0000970)2.69421121
38Optic neuritis (HP:0100653)2.63523800
39Retrobulbar optic neuritis (HP:0100654)2.63523800
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62243321
41Abnormality of alanine metabolism (HP:0010916)2.62243321
42Hyperalaninemia (HP:0003348)2.62243321
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.58113786
44Absent/shortened dynein arms (HP:0200106)2.58113786
45Recurrent abscess formation (HP:0002722)2.54888591
46Abnormal rod and cone electroretinograms (HP:0008323)2.53987779
47Autoamputation (HP:0001218)2.52749797
48Pancreatic islet-cell hyperplasia (HP:0004510)2.48969724
49Abnormal drinking behavior (HP:0030082)2.47039551
50Polydipsia (HP:0001959)2.47039551
51Progressive inability to walk (HP:0002505)2.46575581
52Congenital sensorineural hearing impairment (HP:0008527)2.44085034
53Lissencephaly (HP:0001339)2.43890051
54Abnormality of macular pigmentation (HP:0008002)2.43404965
55Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36813807
56Septo-optic dysplasia (HP:0100842)2.35540339
57Pheochromocytoma (HP:0002666)2.35283216
58Axonal loss (HP:0003447)2.35257956
59Ulnar claw (HP:0001178)2.33934287
60Abnormality of dental color (HP:0011073)2.33565459
61Dysautonomia (HP:0002459)2.32186741
62Mediastinal lymphadenopathy (HP:0100721)2.32106723
63Neuroendocrine neoplasm (HP:0100634)2.30856193
64Cystic liver disease (HP:0006706)2.27460671
65Abnormality of pain sensation (HP:0010832)2.26885201
66Impaired pain sensation (HP:0007328)2.26885201
67Arthropathy (HP:0003040)2.25819643
68Pancreatic fibrosis (HP:0100732)2.22247727
69Decreased central vision (HP:0007663)2.21784516
70Abnormality of the ileum (HP:0001549)2.21196880
71Recurrent bacterial skin infections (HP:0005406)2.21042394
72Abnormality of the aortic arch (HP:0012303)2.18331362
73Hypoproteinemia (HP:0003075)2.18111122
74Molar tooth sign on MRI (HP:0002419)2.15927677
75Abnormality of midbrain morphology (HP:0002418)2.15927677
76Tented upper lip vermilion (HP:0010804)2.14782429
77Recurrent corneal erosions (HP:0000495)2.14608860
78Chorioretinal atrophy (HP:0000533)2.14053654
79Abnormal biliary tract physiology (HP:0012439)2.13116229
80Bile duct proliferation (HP:0001408)2.13116229
81Hypoplasia of the pons (HP:0012110)2.12927799
82Poor head control (HP:0002421)2.12074778
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.11944409
84Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11486171
85Aplasia/Hypoplasia of the spleen (HP:0010451)2.10523523
86Keratitis (HP:0000491)2.09917775
87Polyuria (HP:0000103)2.09655494
88Abnormality of the pons (HP:0007361)2.09427062
89Polyphagia (HP:0002591)2.08929608
90Gingivitis (HP:0000230)2.08782910
91Mesangial abnormality (HP:0001966)2.08366844
92Severe muscular hypotonia (HP:0006829)2.08290306
93Fetal akinesia sequence (HP:0001989)2.08097541
94Inability to walk (HP:0002540)2.08009692
95Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.07744106
96Renal cortical cysts (HP:0000803)2.06016523
97Prostate neoplasm (HP:0100787)2.04138351
98Myositis (HP:0100614)2.03900169
99Abnormality of the vocal cords (HP:0008777)2.01779867
100True hermaphroditism (HP:0010459)2.01570474
101Peripheral hypomyelination (HP:0007182)2.00781672
102Tinnitus (HP:0000360)2.00146636
103Bradycardia (HP:0001662)1.99983097
104Chronic hepatic failure (HP:0100626)1.99978626
105Absent speech (HP:0001344)1.96193697
106Aplasia/Hypoplasia of the tibia (HP:0005772)1.96004838
107Stomach cancer (HP:0012126)1.95690094
108Amelogenesis imperfecta (HP:0000705)1.95649891
109Abnormality of DNA repair (HP:0003254)1.95258390
110Hip dysplasia (HP:0001385)1.94251953
1113-Methylglutaconic aciduria (HP:0003535)1.93722017
112Congenital hepatic fibrosis (HP:0002612)1.92721237
113Abnormal ciliary motility (HP:0012262)1.92698418
114Medial flaring of the eyebrow (HP:0010747)1.92518124
115Asplenia (HP:0001746)1.92303928
116Abnormality of magnesium homeostasis (HP:0004921)1.91814988
117Nephrogenic diabetes insipidus (HP:0009806)1.91641667
118Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90706988
119Oligodontia (HP:0000677)1.89743575
120Keratoconjunctivitis sicca (HP:0001097)1.86892567
121Protruding tongue (HP:0010808)1.85789015
122Ketoacidosis (HP:0001993)1.85658331
123Abnormal eating behavior (HP:0100738)1.85598540
124Hemiparesis (HP:0001269)1.84979184
125Hyperphosphatemia (HP:0002905)1.84829034
126Chronic obstructive pulmonary disease (HP:0006510)1.84528704
127Obstructive lung disease (HP:0006536)1.84528704
128Gait imbalance (HP:0002141)1.84452286
129Fair hair (HP:0002286)1.84201662
130Furrowed tongue (HP:0000221)1.83743078
131Sclerocornea (HP:0000647)1.83696134
132Urinary bladder sphincter dysfunction (HP:0002839)1.83332491
133Parakeratosis (HP:0001036)1.82239337
134Chromsome breakage (HP:0040012)1.81881697
135Failure to thrive in infancy (HP:0001531)1.81526894
136Abnormality of the nasal septum (HP:0000419)1.81444716
137Clumsiness (HP:0002312)1.81118677
138Pulmonary infiltrates (HP:0002113)1.80166184
139Abnormal respiratory motile cilium morphology (HP:0005938)1.79973340
140Abnormal respiratory epithelium morphology (HP:0012253)1.79973340
141Limb dystonia (HP:0002451)1.79707840
142Abnormality of the renal collecting system (HP:0004742)1.78614522
143Keratoconjunctivitis (HP:0001096)1.78206091
144Generalized hypopigmentation of hair (HP:0011358)1.77982970
145Gastrointestinal atresia (HP:0002589)1.77273245
146Absent septum pellucidum (HP:0001331)1.77183016
147Constricted visual fields (HP:0001133)1.77164255
148Abnormality of the corticospinal tract (HP:0002492)1.75596471
149Vasculitis (HP:0002633)1.75182796
150Recurrent gram-negative bacterial infections (HP:0005420)1.74970847
151Bilateral sensorineural hearing impairment (HP:0008619)1.74453627
152Central scotoma (HP:0000603)1.74023308
153Orchitis (HP:0100796)1.72982803
154Stomatitis (HP:0010280)1.72188271
155Aplasia/Hypoplasia of the uvula (HP:0010293)1.71858549
156Hypomagnesemia (HP:0002917)1.71394538
157Oligomenorrhea (HP:0000876)1.70967397
158Thickened helices (HP:0000391)1.70944323
159Pachygyria (HP:0001302)1.70792796
160Broad alveolar ridges (HP:0000187)1.70513057
161Retinitis pigmentosa (HP:0000510)1.70105773
162Genetic anticipation (HP:0003743)1.70059158
163Photophobia (HP:0000613)1.69962413
164Scanning speech (HP:0002168)1.68426475
165Optic nerve hypoplasia (HP:0000609)1.67927653
166Congenital primary aphakia (HP:0007707)1.67634034
167Decreased circulating renin level (HP:0003351)1.67385776
168Esotropia (HP:0000565)1.66981068
169Broad-based gait (HP:0002136)1.66525674
170Spinal canal stenosis (HP:0003416)1.66250067
171Abnormality of binocular vision (HP:0011514)1.66078742
172Diplopia (HP:0000651)1.66078742
173Hypoglycemic seizures (HP:0002173)1.65154381

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.48819106
2CASK5.25520353
3SIK35.02588768
4MAP3K123.88553354
5PINK13.58735897
6RIPK43.40950890
7MAP2K73.13398678
8NTRK32.84364833
9SIK22.77050017
10NTRK12.64688609
11ACVR1B2.36207992
12TXK2.33660020
13ZAK2.18021188
14TAOK31.98590598
15TNIK1.91968380
16SGK21.91074788
17MAP3K41.87884192
18GRK71.81294309
19MAP4K21.80987449
20BMPR1B1.68806595
21MAP3K141.67927010
22STK161.51110913
23PRPF4B1.48412378
24GRK51.46126294
25AKT31.41432366
26OXSR11.41113861
27MATK1.39793032
28YES11.39718226
29SGK31.37383857
30TGFBR11.36700689
31SGK4941.35731200
32SGK2231.35731200
33MINK11.35245026
34WNK41.33696244
35EPHA41.32572914
36MAPK131.30875757
37STK38L1.29472901
38BLK1.28984711
39MARK11.28430398
40MAP2K41.24829408
41IRAK41.23582692
42FES1.20937956
43JAK31.12728730
44STK391.11713332
45PTK2B1.07794906
46MARK31.06811251
47BMPR21.06124143
48PIK3CG1.03304910
49PNCK1.02201709
50TAF11.00394153
51MKNK20.99505307
52BRAF0.99445372
53INSRR0.99435980
54SYK0.98690253
55STK30.98667295
56TEC0.97684665
57NTRK20.97405676
58EIF2AK20.95356272
59DAPK10.94790062
60TIE10.94668370
61DYRK20.94524241
62TLK10.94239913
63TRIM280.88859566
64MAP3K90.88442040
65DYRK30.86301455
66CSNK1G20.86209234
67BRSK20.86143957
68* ADRBK20.84608465
69SIK10.84360687
70PLK40.83746017
71ARAF0.80744260
72BCR0.78875433
73PAK30.77017620
74PLK20.75656450
75EPHA30.75437615
76CSNK1G10.75320629
77TNK20.74424065
78CSNK1A1L0.72505680
79CSNK1G30.71992570
80MUSK0.71593327
81DAPK20.70732815
82NLK0.68634895
83MAPKAPK50.67174474
84IKBKE0.67136757
85ERBB30.66293998
86FGFR20.65295171
87VRK10.63411732
88MKNK10.59116031
89PRKCI0.58950492
90LATS10.58460509
91CDK50.58108850
92* ADRBK10.57328497
93* PRKCG0.57139019
94SGK10.56773789
95CAMKK20.56671048
96LYN0.56408435
97GRK10.56402116
98WNK30.55904161
99DYRK1A0.55392605
100FGR0.54590625
101MAP3K130.54364060
102IRAK30.54098007
103IKBKB0.54013596
104ITK0.52041608
105FLT30.51791570
106TBK10.51074992
107CAMK10.50657398
108ERBB20.49609386
109JAK10.49517656
110IRAK20.49367273
111KIT0.48930272
112* PRKCE0.48792731
113STK110.48725189
114PIM20.48716719
115PRKCD0.47841446
116PHKG10.46535176
117PHKG20.46535176
118CHUK0.45685724
119CAMK1G0.45210786
120CSNK1A10.44268176
121CDK190.44156909
122RPS6KA20.44089607
123* CAMK2A0.43660385
124MAP2K20.43589138
125MYLK0.43353239
126PIK3CA0.41990196
127MAPK110.41900467
128CDC42BPA0.41768366
129CAMK40.41505182
130BTK0.39038510
131CDK80.38925764
132MAP3K70.38375204
133RPS6KA50.37471988
134BCKDK0.36992598
135MST40.36951385
136MAP2K10.36348283
137ABL10.35954869
138TRPM70.35935174
139PRKAA20.35475034
140CSNK1D0.35330769
141* PRKCA0.34867299
142TSSK60.34276440
143TYRO30.34024538
144PRKAA10.33594584
145WNK10.33551929
146PAK60.32911560
147WEE10.32858602
148ZAP700.32819796
149FER0.32771164
150NUAK10.32680153
151MARK20.31562301
152MELK0.31353719
153LCK0.31237584
154EIF2AK30.31091706
155IRAK10.30976402
156MAP2K60.30808878
157PRKG10.30305080
158PRKACA0.29805919
159PRKCQ0.28144827
160RPS6KB10.25347554
161PDK10.22374160
162CLK10.21683894
163STK240.21680214
164* PRKCB0.21406789

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.07362342
2Nitrogen metabolism_Homo sapiens_hsa009102.63354532
3Synaptic vesicle cycle_Homo sapiens_hsa047212.62352649
4Linoleic acid metabolism_Homo sapiens_hsa005912.59385666
5Butanoate metabolism_Homo sapiens_hsa006502.55018246
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.51847888
7Olfactory transduction_Homo sapiens_hsa047402.51267502
8Type I diabetes mellitus_Homo sapiens_hsa049402.41897230
9Graft-versus-host disease_Homo sapiens_hsa053322.27323544
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26436221
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15223655
12* Morphine addiction_Homo sapiens_hsa050322.12153463
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11811792
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07144261
15Allograft rejection_Homo sapiens_hsa053302.05072967
16Rheumatoid arthritis_Homo sapiens_hsa053231.96962449
17Ether lipid metabolism_Homo sapiens_hsa005651.90826610
18* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90016277
19Tryptophan metabolism_Homo sapiens_hsa003801.85835493
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.84392903
21Taste transduction_Homo sapiens_hsa047421.83400926
22ABC transporters_Homo sapiens_hsa020101.79460734
23Collecting duct acid secretion_Homo sapiens_hsa049661.77987910
24Circadian entrainment_Homo sapiens_hsa047131.74273045
25Serotonergic synapse_Homo sapiens_hsa047261.73674384
26Dorso-ventral axis formation_Homo sapiens_hsa043201.73474350
27GABAergic synapse_Homo sapiens_hsa047271.71308775
28Glutamatergic synapse_Homo sapiens_hsa047241.67551403
29Insulin secretion_Homo sapiens_hsa049111.67314783
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59468718
31Cholinergic synapse_Homo sapiens_hsa047251.53330719
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.52186409
33Caffeine metabolism_Homo sapiens_hsa002321.50460227
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.48800531
35Dopaminergic synapse_Homo sapiens_hsa047281.47027390
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.44877447
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44514031
38Basal transcription factors_Homo sapiens_hsa030221.40682290
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39810843
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39747617
41African trypanosomiasis_Homo sapiens_hsa051431.38086272
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37793041
43Homologous recombination_Homo sapiens_hsa034401.34856732
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34753667
45Autoimmune thyroid disease_Homo sapiens_hsa053201.34472897
46Salivary secretion_Homo sapiens_hsa049701.34441527
47Fanconi anemia pathway_Homo sapiens_hsa034601.33959358
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.33469676
49Calcium signaling pathway_Homo sapiens_hsa040201.33051157
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31693388
51Phagosome_Homo sapiens_hsa041451.29898116
52Selenocompound metabolism_Homo sapiens_hsa004501.27158985
53Arachidonic acid metabolism_Homo sapiens_hsa005901.26167393
54Leishmaniasis_Homo sapiens_hsa051401.25678039
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24229192
56Salmonella infection_Homo sapiens_hsa051321.24081601
57Amphetamine addiction_Homo sapiens_hsa050311.24039962
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22725398
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20345869
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19413547
61Long-term potentiation_Homo sapiens_hsa047201.18815674
62Cyanoamino acid metabolism_Homo sapiens_hsa004601.17822366
63Retinol metabolism_Homo sapiens_hsa008301.17630455
64Chemical carcinogenesis_Homo sapiens_hsa052041.17491214
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17240293
66Renin secretion_Homo sapiens_hsa049241.16992138
67Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16807454
68Long-term depression_Homo sapiens_hsa047301.15829728
69Asthma_Homo sapiens_hsa053101.12996297
70Tuberculosis_Homo sapiens_hsa051521.12892947
71One carbon pool by folate_Homo sapiens_hsa006701.12318636
72Glycerolipid metabolism_Homo sapiens_hsa005611.11983228
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11275369
74Cocaine addiction_Homo sapiens_hsa050301.10949093
75Intestinal immune network for IgA production_Homo sapiens_hsa046721.10943714
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10240014
77Pertussis_Homo sapiens_hsa051331.08143187
78Vibrio cholerae infection_Homo sapiens_hsa051101.06871272
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02315283
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96265792
81Chemokine signaling pathway_Homo sapiens_hsa040620.95868405
82Phototransduction_Homo sapiens_hsa047440.93260993
83Hematopoietic cell lineage_Homo sapiens_hsa046400.92253328
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91534156
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91048595
86Propanoate metabolism_Homo sapiens_hsa006400.90894845
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90701194
88Type II diabetes mellitus_Homo sapiens_hsa049300.90488321
89Measles_Homo sapiens_hsa051620.90249927
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.86454781
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84084001
92Oxidative phosphorylation_Homo sapiens_hsa001900.82536955
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82515349
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80995160
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80633290
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79783527
97Gastric acid secretion_Homo sapiens_hsa049710.78706908
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.77801564
99Legionellosis_Homo sapiens_hsa051340.76637418
100Peroxisome_Homo sapiens_hsa041460.76588523
101Oxytocin signaling pathway_Homo sapiens_hsa049210.74728668
102beta-Alanine metabolism_Homo sapiens_hsa004100.73274511
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69304274
104cAMP signaling pathway_Homo sapiens_hsa040240.68665857
105Osteoclast differentiation_Homo sapiens_hsa043800.68467772
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68239366
107Protein export_Homo sapiens_hsa030600.68128857
108Alzheimers disease_Homo sapiens_hsa050100.67557750
109Mineral absorption_Homo sapiens_hsa049780.66646061
110TNF signaling pathway_Homo sapiens_hsa046680.66024631
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65684340
112Sphingolipid metabolism_Homo sapiens_hsa006000.65495541
113Fatty acid degradation_Homo sapiens_hsa000710.65282113
114Histidine metabolism_Homo sapiens_hsa003400.64129543
115Non-homologous end-joining_Homo sapiens_hsa034500.63946402
116Fatty acid biosynthesis_Homo sapiens_hsa000610.63687018
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.63391875
118Influenza A_Homo sapiens_hsa051640.61843641
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.61540561
120Regulation of autophagy_Homo sapiens_hsa041400.61092570
121GnRH signaling pathway_Homo sapiens_hsa049120.60919741
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59041365
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58576233
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58563471
125Primary immunodeficiency_Homo sapiens_hsa053400.57984924
126RNA degradation_Homo sapiens_hsa030180.57764129
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57507538
128Parkinsons disease_Homo sapiens_hsa050120.54981322
129Viral myocarditis_Homo sapiens_hsa054160.54927036
130RNA polymerase_Homo sapiens_hsa030200.52959579
131ErbB signaling pathway_Homo sapiens_hsa040120.50952001
132Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50897097
133Other glycan degradation_Homo sapiens_hsa005110.50857731
134MAPK signaling pathway_Homo sapiens_hsa040100.50770088
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49608862
136Ras signaling pathway_Homo sapiens_hsa040140.49541830
137Gap junction_Homo sapiens_hsa045400.48654781
138Metabolic pathways_Homo sapiens_hsa011000.47799352
139Melanoma_Homo sapiens_hsa052180.47638200
140Prolactin signaling pathway_Homo sapiens_hsa049170.47570373
141Pancreatic secretion_Homo sapiens_hsa049720.46638041
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.46363617
143Starch and sucrose metabolism_Homo sapiens_hsa005000.46327006
144Ovarian steroidogenesis_Homo sapiens_hsa049130.45854640
145Cardiac muscle contraction_Homo sapiens_hsa042600.44771374
146Fat digestion and absorption_Homo sapiens_hsa049750.44302810
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.44054512
148cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43105979
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.41467532
150Inositol phosphate metabolism_Homo sapiens_hsa005620.37998081
151T cell receptor signaling pathway_Homo sapiens_hsa046600.37757130
152Purine metabolism_Homo sapiens_hsa002300.37521070
153Sulfur relay system_Homo sapiens_hsa041220.34044485
154Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31573527
155Folate biosynthesis_Homo sapiens_hsa007900.26381013

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