OPRPN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte differentiation (GO:0030216)8.62278571
2epidermal cell differentiation (GO:0009913)7.54929974
3O-glycan processing (GO:0016266)7.12464950
4apical protein localization (GO:0045176)6.66711959
5hair cell differentiation (GO:0035315)6.41586774
6retina homeostasis (GO:0001895)6.31679986
7establishment of skin barrier (GO:0061436)5.59696440
8negative regulation of homotypic cell-cell adhesion (GO:0034111)5.58065573
9long-chain fatty acid biosynthetic process (GO:0042759)5.47012737
10lipoxygenase pathway (GO:0019372)4.98823361
11regulation of water loss via skin (GO:0033561)4.87966053
12positive regulation of endothelial cell differentiation (GO:0045603)4.84043289
13protein O-linked glycosylation (GO:0006493)4.81309123
14membrane raft organization (GO:0031579)4.60772901
15linoleic acid metabolic process (GO:0043651)4.54235822
16multicellular organismal water homeostasis (GO:0050891)4.53545740
17asymmetric protein localization (GO:0008105)4.44469111
18localization within membrane (GO:0051668)4.31354242
19biomineral tissue development (GO:0031214)4.28024482
20epidermis development (GO:0008544)4.24291682
21regulation of integrin-mediated signaling pathway (GO:2001044)4.20738468
22negative regulation of interleukin-17 production (GO:0032700)4.16908532
23water homeostasis (GO:0030104)4.15199651
24digestive system process (GO:0022600)4.12882722
25negative regulation of cell-cell adhesion (GO:0022408)4.03086158
26antimicrobial humoral response (GO:0019730)3.96818334
27regulation of platelet aggregation (GO:0090330)3.94303198
28regulation of bile acid biosynthetic process (GO:0070857)3.91625497
29positive regulation of p38MAPK cascade (GO:1900745)3.89862590
30regulation of bone mineralization (GO:0030500)3.79394357
31negative regulation of platelet activation (GO:0010544)3.69834196
32regulation of endothelial cell differentiation (GO:0045601)3.69234860
33regulation of protein polyubiquitination (GO:1902914)3.55800010
34regulation of biomineral tissue development (GO:0070167)3.54955331
35negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.53831515
36toxin metabolic process (GO:0009404)3.53341300
37negative regulation of ossification (GO:0030279)3.46220493
38intestinal epithelial cell development (GO:0060576)3.38457321
39regulation of cholesterol homeostasis (GO:2000188)3.36873956
40superoxide anion generation (GO:0042554)3.35537018
41negative regulation of cytokine-mediated signaling pathway (GO:0001960)3.34347834
42positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.32387616
43transepithelial transport (GO:0070633)3.28602749
44regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.23969986
45positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.23969986
46secretion by tissue (GO:0032941)3.23111717
47negative regulation of response to cytokine stimulus (GO:0060761)3.22023735
48regulation of mitochondrial depolarization (GO:0051900)3.20319461
49regulation of p38MAPK cascade (GO:1900744)3.13617899
50positive regulation of vasodilation (GO:0045909)3.12335296
51regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.11358154
52auditory receptor cell differentiation (GO:0042491)3.10874326
53desmosome organization (GO:0002934)3.04444330
54defense response to fungus (GO:0050832)2.98784850
55positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.92944468
56regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.92944468
57macroautophagy (GO:0016236)2.90817019
58ectoderm development (GO:0007398)2.86918851
59positive regulation of chemokine biosynthetic process (GO:0045080)2.79766922
60negative regulation of cell-substrate adhesion (GO:0010812)2.79030432
61positive regulation of chemokine secretion (GO:0090197)2.78859724
62positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.78238410
63body fluid secretion (GO:0007589)2.76343438
64interkinetic nuclear migration (GO:0022027)2.73235603
65early endosome to late endosome transport (GO:0045022)2.71512226
66one-carbon compound transport (GO:0019755)2.70264132
67regulation of membrane protein ectodomain proteolysis (GO:0051043)2.67389576
68regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.65439297
69excretion (GO:0007588)2.62561236
70response to vitamin A (GO:0033189)2.59811538
71bundle of His cell to Purkinje myocyte communication (GO:0086069)2.59772871
72regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.58578676
73negative regulation of muscle cell apoptotic process (GO:0010656)2.57122771
74endothelial cell chemotaxis (GO:0035767)2.56613142
75lung lobe morphogenesis (GO:0060463)2.55441352
76epithelial cell differentiation (GO:0030855)2.50234120
77fibroblast migration (GO:0010761)2.48157191
78regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.45209031
79glomerular filtration (GO:0003094)2.44520719
80regulation of female receptivity (GO:0045924)2.44460803
81regulation of glycogen (starch) synthase activity (GO:2000465)2.42162478
82embryonic process involved in female pregnancy (GO:0060136)2.42005152
83wound healing (GO:0042060)2.41730798
84regulation of interleukin-17 production (GO:0032660)2.40005979
85negative regulation of complement activation (GO:0045916)2.39987991
86mesenchymal cell differentiation involved in kidney development (GO:0072161)2.38991209
87mesenchymal cell differentiation involved in renal system development (GO:2001012)2.38991209
88regulation of hippo signaling (GO:0035330)2.34778977
89negative regulation of vascular permeability (GO:0043116)2.34354682
90metanephric mesenchyme development (GO:0072075)2.31547912
91planar cell polarity pathway involved in neural tube closure (GO:0090179)2.30300611
92microtubule nucleation (GO:0007020)2.28951153
93hippo signaling (GO:0035329)2.26254419
94ossification (GO:0001503)2.25049432
95eyelid development in camera-type eye (GO:0061029)2.24986076
96negative regulation of kidney development (GO:0090185)2.24403090
97keratinization (GO:0031424)14.8392357
98negative regulation of bone mineralization (GO:0030502)13.0743836
99negative regulation of biomineral tissue development (GO:0070168)11.5881704
100peptide cross-linking (GO:0018149)10.6718809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human3.28556102
2ESR1_20079471_ChIP-ChIP_T-47D_Human3.17029707
3ZNF217_24962896_ChIP-Seq_MCF-7_Human3.00007290
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.91002641
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.25261091
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.17582911
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.16778186
8TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.08569865
9SOX2_20726797_ChIP-Seq_SW620_Human1.96032179
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91542773
11CDX2_19796622_ChIP-Seq_MESCs_Mouse1.88344776
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.85544208
13FOXM1_26456572_ChIP-Seq_MCF-7_Human1.82681182
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82637029
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81306098
16ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78816265
17NFIB_24661679_ChIP-Seq_LUNG_Mouse1.77475758
18FOXO3_23340844_ChIP-Seq_DLD1_Human1.76236273
19AHR_22903824_ChIP-Seq_MCF-7_Human1.75009501
20SOX9_24532713_ChIP-Seq_HFSC_Mouse1.74222721
21CJUN_26792858_Chip-Seq_BT549_Human1.72137293
22ARNT_22903824_ChIP-Seq_MCF-7_Human1.69950924
23GATA2_21666600_ChIP-Seq_HMVEC_Human1.69820827
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64136239
25GATA3_24758297_ChIP-Seq_MCF-7_Human1.60833202
26RXR_22108803_ChIP-Seq_LS180_Human1.56117020
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.55550672
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.49431677
29FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.48677698
30SOX2_27498859_Chip-Seq_STOMACH_Mouse1.46678909
31GATA4_25053715_ChIP-Seq_YYC3_Human1.45577424
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42865313
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39641959
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38375486
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.38277870
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.37727089
37ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37001176
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34108495
39VDR_22108803_ChIP-Seq_LS180_Human1.33327668
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.31210595
41HTT_18923047_ChIP-ChIP_STHdh_Human1.30041420
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29594788
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.28886083
44BCAT_22108803_ChIP-Seq_LS180_Human1.28520880
45FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28201283
46SMAD3_21741376_ChIP-Seq_HESCs_Human1.25097412
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.24860090
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24545690
49CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22657248
50SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22610715
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22610715
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22114250
53GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.20943275
54KLF5_25053715_ChIP-Seq_YYC3_Human1.20373737
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19441597
56FOXA1_25552417_ChIP-Seq_VCAP_Human1.18731562
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18110503
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17327673
59ERG_20517297_ChIP-Seq_VCAP_Human1.16353641
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.16048116
61GATA6_21074721_ChIP-Seq_CACO-2_Human1.15328679
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14473752
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.13653067
64AR_25329375_ChIP-Seq_VCAP_Human1.10539957
65GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.10439979
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09701736
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08153402
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08153402
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07828089
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07335695
71TP63_23658742_ChIP-Seq_EP156T_Human1.06539112
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02622766
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.02562994
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02102116
75SMAD4_21799915_ChIP-Seq_A2780_Human1.00785989
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99918517
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99847938
78FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99483055
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99125441
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97467890
81FOXA2_19822575_ChIP-Seq_HepG2_Human0.97199422
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96611880
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94691238
84P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94688244
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93886830
86PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93717299
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93079895
88NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92199105
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91519363
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91375570
91RXR_22158963_ChIP-Seq_LIVER_Mouse0.90713261
92TBX20_22080862_ChIP-Seq_HEART_Mouse0.88989493
93TBX20_22328084_ChIP-Seq_HEART_Mouse0.88989493
94RBPJ_21746931_ChIP-Seq_IB4_Human0.87739413
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86920977
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85721001
97TBL1_22424771_ChIP-Seq_293T_Human0.85581741
98CDX2_22108803_ChIP-Seq_LS180_Human0.85437797
99TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.84870148
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84701181

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile6.14687052
2MP0002796_impaired_skin_barrier4.44238886
3MP0004043_abnormal_pH_regulation4.35367647
4MP0009780_abnormal_chondrocyte_physiolo3.71397058
5MP0010352_gastrointestinal_tract_polyps3.37178762
6MP0005501_abnormal_skin_physiology2.88495024
7MP0005670_abnormal_white_adipose2.80171696
8MP0010678_abnormal_skin_adnexa2.73335458
9MP0005503_abnormal_tendon_morphology2.64168383
10MP0005666_abnormal_adipose_tissue2.10702015
11MP0002138_abnormal_hepatobiliary_system2.03103058
12MP0010234_abnormal_vibrissa_follicle11.0713789
13MP0003724_increased_susceptibility_to1.87220141
14MP0004185_abnormal_adipocyte_glucose1.86851524
15MP0010368_abnormal_lymphatic_system1.82840194
16MP0002139_abnormal_hepatobiliary_system1.80028957
17MP0005375_adipose_tissue_phenotype1.70188705
18MP0010386_abnormal_urinary_bladder1.55256320
19MP0002166_altered_tumor_susceptibility1.54889348
20MP0001756_abnormal_urination1.44139890
21MP0010771_integument_phenotype1.39893594
22MP0000678_abnormal_parathyroid_gland1.39730241
23MP0005365_abnormal_bile_salt1.38698253
24MP0002098_abnormal_vibrissa_morphology1.38060673
25MP0002876_abnormal_thyroid_physiology1.37501207
26MP0000467_abnormal_esophagus_morphology1.36956335
27MP0001851_eye_inflammation1.33038931
28MP0000465_gastrointestinal_hemorrhage1.32563063
29MP0004130_abnormal_muscle_cell1.31288885
30MP0001502_abnormal_circadian_rhythm1.31208801
31MP0009115_abnormal_fat_cell1.23771506
32MP0001765_abnormal_ion_homeostasis1.22561014
33MP0001216_abnormal_epidermal_layer1.22403080
34MP0003453_abnormal_keratinocyte_physiol1.21117243
35MP0002108_abnormal_muscle_morphology1.20869990
36MP0000003_abnormal_adipose_tissue1.16053716
37MP0010329_abnormal_lipoprotein_level1.11493859
38MP0001879_abnormal_lymphatic_vessel1.09661077
39MP0002249_abnormal_larynx_morphology1.09442561
40MP0000681_abnormal_thyroid_gland1.07118475
41MP0003868_abnormal_feces_composition1.04127608
42MP0005636_abnormal_mineral_homeostasis0.99124376
43MP0006138_congestive_heart_failure0.98056550
44MP0002060_abnormal_skin_morphology0.97740528
45MP0003828_pulmonary_edema0.95447938
46MP0005409_darkened_coat_color0.93860369
47MP0005448_abnormal_energy_balance0.93660793
48MP0000377_abnormal_hair_follicle0.93611002
49MP0000613_abnormal_salivary_gland0.92087494
50MP0002971_abnormal_brown_adipose0.89228180
51MP0003879_abnormal_hair_cell0.88451268
52MP0001784_abnormal_fluid_regulation0.87801693
53MP0004264_abnormal_extraembryonic_tissu0.84001923
54MP0003705_abnormal_hypodermis_morpholog0.83724941
55MP0005646_abnormal_pituitary_gland0.81562497
56MP0002933_joint_inflammation0.81472223
57MP0003646_muscle_fatigue0.77974393
58MP0009333_abnormal_splenocyte_physiolog0.77290721
59MP0000566_synostosis0.77202440
60MP0005645_abnormal_hypothalamus_physiol0.77148737
61MP0002006_tumorigenesis0.76685839
62MP0005166_decreased_susceptibility_to0.76374966
63MP0009643_abnormal_urine_homeostasis0.74522452
64MP0004019_abnormal_vitamin_homeostasis0.74048071
65MP0005023_abnormal_wound_healing0.73800054
66MP0001853_heart_inflammation0.72662611
67MP0002136_abnormal_kidney_physiology0.66364941
68MP0003938_abnormal_ear_development0.64535492
69MP0008961_abnormal_basal_metabolism0.62696502
70MP0000762_abnormal_tongue_morphology0.62299628
71MP0000470_abnormal_stomach_morphology0.61123029
72MP0001958_emphysema0.60814211
73MP0003638_abnormal_response/metabolism_0.60362885
74MP0002118_abnormal_lipid_homeostasis0.58612038
75MP0001501_abnormal_sleep_pattern0.57836254
76MP0004885_abnormal_endolymph0.57597113
77MP0000462_abnormal_digestive_system0.56833630
78MP0000631_abnormal_neuroendocrine_gland0.56491787
79MP0003183_abnormal_peptide_metabolism0.55996281
80MP0004947_skin_inflammation0.55705885
81MP0000230_abnormal_systemic_arterial0.54487338
82MP0005164_abnormal_response_to0.53521847
83MP0000920_abnormal_myelination0.51767897
84MP0003122_maternal_imprinting0.51565948
85MP0003252_abnormal_bile_duct0.51004266
86MP0009931_abnormal_skin_appearance0.50609880
87MP0005535_abnormal_body_temperature0.50312831
88MP0005248_abnormal_Harderian_gland0.50175494
89MP0000371_diluted_coat_color0.48426457
90MP0001243_abnormal_dermal_layer0.48291176
91MP0005647_abnormal_sex_gland0.47910665
92MP0002168_other_aberrant_phenotype0.47472003
93MP0002128_abnormal_blood_circulation0.47224976
94MP0001270_distended_abdomen0.46428900
95MP0004883_abnormal_blood_vessel0.45792587
96MP0002970_abnormal_white_adipose0.45019384
97MP0000733_abnormal_muscle_development0.44674251
98MP0002127_abnormal_cardiovascular_syste0.43827482
99MP0001944_abnormal_pancreas_morphology0.42549815
100MP0003045_fibrosis0.41958492

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.48949082
2Pustule (HP:0200039)8.40094182
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.26153255
4Hyperactive renin-angiotensin system (HP:0000841)7.14720021
5Villous atrophy (HP:0011473)5.87031601
6Abnormality of small intestinal villus morphology (HP:0011472)5.87031601
7Lip pit (HP:0100267)5.78199242
8Hyperkalemia (HP:0002153)5.50397675
9Congenital ichthyosiform erythroderma (HP:0007431)4.95711669
10Decreased circulating renin level (HP:0003351)4.84824081
11Erythroderma (HP:0001019)4.73645131
12Parakeratosis (HP:0001036)4.68543374
13Sparse scalp hair (HP:0002209)4.46197638
14Acanthosis nigricans (HP:0000956)4.25109337
15Hypokalemic alkalosis (HP:0001949)4.20411346
16Oral leukoplakia (HP:0002745)4.00947734
17Nasal polyposis (HP:0100582)3.95337021
18Abnormality of renin-angiotensin system (HP:0000847)3.93413193
19Abnormality of chloride homeostasis (HP:0011422)3.77331610
20Neonatal hypoglycemia (HP:0001998)3.76570635
21Hyperaldosteronism (HP:0000859)3.66688226
22Abnormality of the nasal mucosa (HP:0000433)3.53138292
23Chronic bronchitis (HP:0004469)3.52097452
24Brittle hair (HP:0002299)3.37147848
25Renal salt wasting (HP:0000127)3.33024486
26Dehydration (HP:0001944)3.31051301
27Eczematoid dermatitis (HP:0000976)3.25597987
28Right ventricular cardiomyopathy (HP:0011663)3.13941976
29Emphysema (HP:0002097)3.00891679
30Cystic hygroma (HP:0000476)2.94910465
31Increased circulating renin level (HP:0000848)2.87841897
32Absence seizures (HP:0002121)2.78735882
33Oligodontia (HP:0000677)2.73305277
34Obstructive sleep apnea (HP:0002870)2.68931008
35Abnormality of potassium homeostasis (HP:0011042)2.63621728
36Papillary thyroid carcinoma (HP:0002895)2.59531343
37Choroideremia (HP:0001139)2.55318195
38Complement deficiency (HP:0004431)2.55292969
39Abnormality of the salivary glands (HP:0010286)2.45742647
40Ulnar claw (HP:0001178)2.42771470
41Oligodactyly (hands) (HP:0001180)2.37961162
42Adrenal overactivity (HP:0002717)2.31729155
43Furrowed tongue (HP:0000221)2.30781552
44Alkalosis (HP:0001948)2.28823575
45Erythema (HP:0010783)2.22015006
46Malnutrition (HP:0004395)2.21951718
47Acne (HP:0001061)2.16169503
48Labial hypoplasia (HP:0000066)2.15765715
49Hypergammaglobulinemia (HP:0010702)2.10814950
50Hypoplastic labia majora (HP:0000059)2.10415169
51Hypokalemia (HP:0002900)2.05437318
52Distal lower limb muscle weakness (HP:0009053)2.04549375
53Low posterior hairline (HP:0002162)2.00957147
54Dialeptic seizures (HP:0011146)2.00929321
55Hyponatremia (HP:0002902)2.00715408
56Thoracolumbar scoliosis (HP:0002944)1.98334936
57Laryngomalacia (HP:0001601)1.96377951
58Hip dysplasia (HP:0001385)1.96304377
59Hoarse voice (HP:0001609)1.95939126
60Thickened nuchal skin fold (HP:0000474)1.93718659
61Autoamputation (HP:0001218)1.92061360
62Sleep apnea (HP:0010535)1.91032281
63Abnormality of the labia majora (HP:0012881)1.90446586
64Abnormality of complement system (HP:0005339)1.89843713
65Urticaria (HP:0001025)1.87371303
66Glomerulonephritis (HP:0000099)1.86467407
67Hypoplastic female external genitalia (HP:0012815)1.85028640
68Vascular calcification (HP:0004934)1.81767323
69Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81693170
70Abnormality of the dental root (HP:0006486)1.80080441
71Taurodontia (HP:0000679)1.80080441
72Abnormality of permanent molar morphology (HP:0011071)1.80080441
73Hypotension (HP:0002615)1.79714373
74Bilateral sensorineural hearing impairment (HP:0008619)1.79688826
75Abnormality of the fingertips (HP:0001211)1.79591124
76Delusions (HP:0000746)1.79108739
77Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.78313604
78Abnormal pancreas size (HP:0012094)1.76425597
79Ectropion (HP:0000656)1.75935506
80Systemic lupus erythematosus (HP:0002725)1.75885779
81Polar cataract (HP:0010696)1.73268184
82Oligodactyly (HP:0012165)1.71214184
83Abnormality of the dental pulp (HP:0006479)1.70968274
84Skin pits (HP:0100276)1.70487561
85Abnormality of sodium homeostasis (HP:0010931)1.69293961
86Asthma (HP:0002099)1.66425179
87Abnormality of macular pigmentation (HP:0008002)1.66301586
88Abnormality of molar morphology (HP:0011070)1.66072488
89Abnormality of molar (HP:0011077)1.66072488
90Hyperventilation (HP:0002883)1.65150672
91Hyperphosphatemia (HP:0002905)1.64054463
92Cardiovascular calcification (HP:0011915)1.62325797
93Abnormality of the labia (HP:0000058)1.61240063
94Hyperglycemia (HP:0003074)1.60683048
95Muscle fiber splitting (HP:0003555)1.60220460
96Advanced eruption of teeth (HP:0006288)1.60208659
97Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.59123229
98Segmental peripheral demyelination/remyelination (HP:0003481)1.58273314
99Increased CSF protein (HP:0002922)1.56296902
100Congenital malformation of the right heart (HP:0011723)1.55887922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.86625587
2CAMK1D3.48052888
3WNK13.32955575
4STK393.17775942
5RIPK12.92550711
6MAP3K92.92217010
7CAMK1G2.79450468
8SGK22.77384408
9WNK42.69297257
10MST42.62191865
11SGK32.44706303
12AKT32.23488353
13SGK4942.12124575
14SGK2232.12124575
15NME12.09782039
16LRRK22.01467777
17STK241.87453614
18TYRO31.86605136
19PRKD31.86432168
20MARK21.81445024
21MAP3K21.71187708
22DAPK21.68745430
23LATS11.65000047
24PIK3CA1.59329613
25MAPKAPK31.55095662
26UHMK11.52894694
27TRPM71.46723343
28EPHA21.43447943
29OXSR11.22112852
30PDGFRB1.16488631
31OBSCN1.16237478
32PRKAA21.15268887
33TAOK31.13176141
34MAP3K121.03182128
35FER1.02122597
36STK30.99125539
37CSK0.90206295
38FGFR10.82952865
39SGK10.81217332
40CHUK0.79894688
41ACVR1B0.79408565
42HIPK20.79259884
43DMPK0.77487119
44IKBKE0.76998605
45RPS6KA20.76577296
46AKT20.76249894
47PINK10.75407333
48ERBB30.74782925
49PRKD20.74512293
50NLK0.70008355
51SIK10.68397232
52MAP3K70.67375402
53IRAK10.66844151
54MET0.64450475
55MAP3K30.63153323
56STK380.62474422
57MTOR0.61188296
58MAPK150.60510120
59ERN10.59658432
60CAMK10.56703524
61MAPK70.55478239
62PHKG10.54690725
63PHKG20.54690725
64TESK10.54094491
65BMPR1B0.53343920
66RPS6KB10.51227001
67MAP3K10.50835352
68CAMK40.50522018
69MAPK10.50119537
70MAP3K40.49619415
71MAPK30.47771394
72DDR20.46744654
73PTK20.45525388
74PRKCH0.44929056
75CDC42BPA0.44537016
76MYLK0.44296988
77PRKCE0.43262646
78CDK120.42197822
79ITK0.40571604
80MAP3K60.40260114
81MAP2K10.39752778
82RPS6KA10.38706232
83PRKAA10.38283043
84TIE10.37955459
85NTRK30.36612114
86RPS6KA30.35973138
87CSNK2A20.33414512
88TAOK10.32145948
89AKT10.31632521
90ROCK10.31427172
91STK38L0.31154154
92ADRBK10.30083798
93RET0.29768912
94TBK10.29296991
95PRKG10.28873328
96BCR0.28757702
97PRKCZ0.28664657
98MAP2K60.28524597
99CDK90.27312241
100PRKACG0.26477082

Predicted pathways (KEGG)

RankGene SetZ-score
1Salivary secretion_Homo sapiens_hsa049705.83519153
2Circadian rhythm_Homo sapiens_hsa047103.26645093
3Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.90507196
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.39383061
5Arachidonic acid metabolism_Homo sapiens_hsa005902.15637056
6Collecting duct acid secretion_Homo sapiens_hsa049661.99221758
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91913037
8Sulfur metabolism_Homo sapiens_hsa009201.87610889
9Complement and coagulation cascades_Homo sapiens_hsa046101.81229763
10Adherens junction_Homo sapiens_hsa045201.78817387
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77207664
12Notch signaling pathway_Homo sapiens_hsa043301.55901920
13Phenylalanine metabolism_Homo sapiens_hsa003601.50122920
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44293470
15Chemical carcinogenesis_Homo sapiens_hsa052041.43935964
16Tight junction_Homo sapiens_hsa045301.43842784
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.41620227
18Histidine metabolism_Homo sapiens_hsa003401.36019908
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.26449968
20Serotonergic synapse_Homo sapiens_hsa047261.25746178
21Vibrio cholerae infection_Homo sapiens_hsa051101.23472826
22Dorso-ventral axis formation_Homo sapiens_hsa043201.19536958
23Tyrosine metabolism_Homo sapiens_hsa003501.17840210
24PPAR signaling pathway_Homo sapiens_hsa033201.17035014
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.08050043
26Arginine biosynthesis_Homo sapiens_hsa002201.07375912
27Glucagon signaling pathway_Homo sapiens_hsa049221.04279012
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02533915
29Amoebiasis_Homo sapiens_hsa051461.01067797
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98615836
31Glutathione metabolism_Homo sapiens_hsa004800.96976989
32Steroid hormone biosynthesis_Homo sapiens_hsa001400.95444561
33Malaria_Homo sapiens_hsa051440.90901329
34Pertussis_Homo sapiens_hsa051330.90788959
35Insulin resistance_Homo sapiens_hsa049310.90666525
36Linoleic acid metabolism_Homo sapiens_hsa005910.87976584
37Synaptic vesicle cycle_Homo sapiens_hsa047210.83761368
38Renin secretion_Homo sapiens_hsa049240.83023743
39Lysine degradation_Homo sapiens_hsa003100.81014831
40Retinol metabolism_Homo sapiens_hsa008300.77870945
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77247104
42Mineral absorption_Homo sapiens_hsa049780.76791991
43beta-Alanine metabolism_Homo sapiens_hsa004100.76681352
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.75899565
45Bile secretion_Homo sapiens_hsa049760.75446587
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74194108
47Insulin signaling pathway_Homo sapiens_hsa049100.72370653
48Renal cell carcinoma_Homo sapiens_hsa052110.72285448
49Nitrogen metabolism_Homo sapiens_hsa009100.71783689
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70740626
51Insulin secretion_Homo sapiens_hsa049110.70406130
52TGF-beta signaling pathway_Homo sapiens_hsa043500.69940692
53Cocaine addiction_Homo sapiens_hsa050300.69209734
54Acute myeloid leukemia_Homo sapiens_hsa052210.68670961
55TNF signaling pathway_Homo sapiens_hsa046680.65646786
56Staphylococcus aureus infection_Homo sapiens_hsa051500.65560175
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63690505
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63121474
59Pancreatic secretion_Homo sapiens_hsa049720.62777773
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62346470
61Endocytosis_Homo sapiens_hsa041440.62261420
62FoxO signaling pathway_Homo sapiens_hsa040680.62229148
63AMPK signaling pathway_Homo sapiens_hsa041520.61345295
64Prostate cancer_Homo sapiens_hsa052150.60084384
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60051357
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57809709
67African trypanosomiasis_Homo sapiens_hsa051430.57522960
68cAMP signaling pathway_Homo sapiens_hsa040240.56906119
69GnRH signaling pathway_Homo sapiens_hsa049120.56373769
70Chemokine signaling pathway_Homo sapiens_hsa040620.55582178
71Long-term potentiation_Homo sapiens_hsa047200.55059093
72Ovarian steroidogenesis_Homo sapiens_hsa049130.55034404
73Fatty acid biosynthesis_Homo sapiens_hsa000610.54088991
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.53956322
75Hepatitis C_Homo sapiens_hsa051600.53463422
76Axon guidance_Homo sapiens_hsa043600.51026986
77Rheumatoid arthritis_Homo sapiens_hsa053230.50490062
78Fatty acid degradation_Homo sapiens_hsa000710.49071704
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47119236
80Renin-angiotensin system_Homo sapiens_hsa046140.46429377
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45878726
82Ether lipid metabolism_Homo sapiens_hsa005650.45763332
83Thyroid cancer_Homo sapiens_hsa052160.45582195
84Amphetamine addiction_Homo sapiens_hsa050310.45450607
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44720748
86Prolactin signaling pathway_Homo sapiens_hsa049170.44544636
87Wnt signaling pathway_Homo sapiens_hsa043100.44192794
88Long-term depression_Homo sapiens_hsa047300.44021310
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43493168
90Ras signaling pathway_Homo sapiens_hsa040140.43022336
91Focal adhesion_Homo sapiens_hsa045100.42765355
92Rap1 signaling pathway_Homo sapiens_hsa040150.42221191
93ABC transporters_Homo sapiens_hsa020100.41550868
94MAPK signaling pathway_Homo sapiens_hsa040100.41342697
95Starch and sucrose metabolism_Homo sapiens_hsa005000.40847713
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38055620
97Estrogen signaling pathway_Homo sapiens_hsa049150.37986511
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36728637
99Thyroid hormone synthesis_Homo sapiens_hsa049180.35495377
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34932422

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